Document Type and Number:
Japanese Patent JPH07504422
Kind Code:
A
Abstract:
Compounds are described of formula (I), wherein R<1> represents a hydroxyl group or a group selected from -OCOCH=CHCH(CH3)(CH2)3CH3, -OCOCH=CHC(CH3)=CHCH(CH3)CH2CH3 or -OCO-X-CH2CH(CH3)CH2CH3 [where X is -CH=CHCH(CH3)-, -CH2CH(OH)CH(CH3)-, -CH=CHC(OH)(CH3)-, -CH2CH(OH)CH2- or -CH2CH2CH(CH3)-]; R<2> represents a hydroxyl group; R<3> represents a group selected from (1) (where R<7> is a hydrogen atom or an acetyl group), -C(CH3)=CHCH(CH2R<8>)CH2Ph (where R<8> is a hydrogen or a hydroxyl group), -C(CH2OH)=CHCH(CH3)CH2Ph, -C(=CH2)CH(OH)CH(CH2OH)CH2Ph, -C(=CH2)CH(NHCOCH3)CH(CH3)CH2Ph, -C(CH2NHCOCH3)=CHCH(CH3)CH2Ph and (2); R<4> and R<5> may each independently represent a hydrogen atom or a methyl group; R<6> represents a tetrazole ring linked via the ring carbon atom to the rest of the molecule and optionally substituted at one of the ring nitrogen atoms by a C1-4alkyl group; and salts thereof. These compounds inhibit the enzyme squalene synthase and/or are intermediates for the preparation of compounds which inhibit the enzyme squalene synthase. Compounds of the inventions may be formulated for use in a variety of conditions where a lowering of the level of blood plasma cholesterol in animals would be beneficial and for use in combating fungal infections in animals.
Application Number:
JP51531893A
Publication Date:
May 18, 1995
Filing Date:
March 02, 1993
Export Citation:
International Classes:
C07H9/02; A61K31/34; A61K31/70; A61K31/7028; A61P3/00; A61P3/06; A61P9/08; A61P9/10; A61P31/04; A61P43/00; C07D493/08; C07H9/04; C07H15/10; C07H19/01; (IPC1-7): C07D493/08; A61K31/34; A61K31/70; C07H9/02; C07H15/10