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Document Type and Number:
Japanese Patent JPH07505147
Kind Code:
Compounds of formula (I), and salts and prodrugs thereof (I) wherein Q1 is halo substituted phenyl; naphthyl; indolyl; benzthiophenyl; benzofuranyl; benzyl; or fluorenyl; . . . is an optional covalent bond; one of X and Y is H and the other is hydroxy or C1-6alkoxy, or X and Y are together =0 or =NOR5; R1 and R2 are H; C1-6alkyl optionally substituted by hydroxy, cyano, CORc, CO2Rc, CONRcRd, or NRcRd (where Rc and Rd are H, C1-6alkyl or phenyl(C0-4alkyl) optionally substituted by C1-6alkyl, C1-6alkoxy, halo and trifluoromethyl); phenyl(C1-4alkyl) (optionally substituted by C1-6alkyl, C1-6alkoxy, halo or trifluoromethyl); CORc; CO2Rc; CONRcRd; COC1-6alkylNRcRd; CONRcCOORd; or SO2Rc; R3 is H, C1-6alkyl or C2-6alkenyl; and R4 is phenyl optionally substituted by C1-6alkyl, C2-6alkenyl, C2-6alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, ORa, SRa, SORa, NRaRb, NRaCORb, NRaCO2Rb, CO2Ra or CONRaRb, where Ra and Rb are H, C1-6alkyl, phenyl or trifluoromethyl; are tachykinin antagonists.

Lewis, Richard Yard Thomas
Macleod, Angus Murray
Marchinto, Kevin Jiyoung
Application Number:
Publication Date:
June 08, 1995
Filing Date:
February 26, 1993
Export Citation:
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Merck Sharp End Dome Limited
International Classes:
C07D333/60; A61K31/34; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61P43/00; C07C237/22; C07C239/08; C07C251/40; C07C255/24; C07C255/30; C07C317/28; C07C323/24; C07D209/14; C07D209/16; C07D307/81; C07D333/58; C07K1/113; C07K5/02; (IPC1-7): C07C237/22; A61K31/38; A61K31/40; C07C239/08; C07C251/40; C07C255/24; C07C255/30; C07C317/28; C07C323/24; C07D209/14; C07D307/81; C07D333/60; C07K5/02
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)

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