Title:
【発明の名称】ピペリジン類似体とプロカインアミド及びNAPAの結合体
Document Type and Number:
Japanese Patent JPH09508393
Kind Code:
A
Abstract:
Novel derivatives of procainamide and N-acetylprocainamide (NAPA) are disclosed having the following formula: wherein: X=hydrogen or acetyl; n=1 to p where p=MW of Z/1000; Z=a poly(amino acid) or polysaccharide; and R3=a bond or aving 2 to 10 carbon atoms. The derivatives include maleimide conjugates of proteins or poly(amino acids), enzymes, enzyme donor polypeptides and labeling substances. Novel activated hapten intermediates useful in the preparation of the conjugates and methods for synthesis of the hapten intermediates and derivatives are also disclosed.
Inventors:
Schirger, Gerald F.
Walter, Charles F.
Tony, Gracy
Klein, Frank E.
Hoover, Erasmus
Walter, Charles F.
Tony, Gracy
Klein, Frank E.
Hoover, Erasmus
Application Number:
JP52024595A
Publication Date:
August 26, 1997
Filing Date:
January 31, 1995
Export Citation:
Assignee:
Boehringer Mannheim Corporation
International Classes:
A61K39/385; C07D211/60; C07D211/62; C07D401/12; C07K14/47; C07K16/44; C08B37/00; C12N9/96; G01N33/531; G01N33/542; G01N33/577; G01N33/53; G01N33/94; (IPC1-7): C07D211/60; C07D401/12; C07K14/47; C07K16/44; C08B37/00; C12N9/96; G01N33/53; G01N33/531; G01N33/542; G01N33/577
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)