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Patent Searching and Data

Document Type and Number:
Japanese Patent JPH09508394
Kind Code:
A method for the treatment of a host, and in particular, a human, infected with HBV or EBV is provided that includes administering an HBV- or EBV- treatment amount of an L-nucleoside of formula (I) wherein R is a purine or pyrimidine base. In one preferred embodiment, the active compound is 2'-fluoro-5-methyl- beta -L-arabinofuranosyluridine (also referred to as L-FMAU) This compound is a potent antiviral agent against HBV and EBV and exhibits low cytotoxicity. Other specific examples of active compounds include N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-ethyluracil, N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-iodocytosine), and N1-(2'-deoxy-2'-fluoro- beta -L-arabinofuranosyl)-5-iodouracil.

Chu, Chang, Kay
Chen, Yun Ji
Pie, Balakrishna, Es
Yao, Gyan Kin
Application Number:
Publication Date:
August 26, 1997
Filing Date:
January 30, 1995
Export Citation:
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University, Of, Georgia, Research, Foundation, Incorporated
Yale, University
International Classes:
C07H19/09; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61P31/12; C07H19/00; C07H19/06; C07H19/16; C07H19/19; C07H19/20; C07H21/00; (IPC1-7): C07H19/09; A61K31/70; C07H19/19
Attorney, Agent or Firm:
Michio Akaoka (1 person outside)