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Title:
キメラCD4レセプターを有する細胞によるHIV感染細胞を標的とする細胞傷害
Document Type and Number:
Japanese Patent JPH09512421
Kind Code:
A
Abstract:
Disclosed is a method of directing a cellular immune response against an HIV-infected cell in a mammal involving administering to the mammal an effective amount of therapeutic cells which express a membrane-bound, proteinaceous chimeric receptor comprising (a) an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection and (b) an intracellular portion which is capable of signalling the therapeutic cell to destroy the receptor-bound HIV-infected cell. Also disclosed are cells which express the chimeric receptors and DNA and vectors encoding the chimeric receptors.

Inventors:
コラヌス バルデマー
シード ブライアン
バナポア ババク
ロミオ チャールズ
Application Number:
JP52121395A
Publication Date:
December 16, 1997
Filing Date:
January 12, 1995
Export Citation:
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Assignee:
ザ ジェネラル ホスピタル コーポレーション
International Classes:
C12N15/09; A61K35/12; A61K35/13; A61K35/14; A61K35/15; A61K35/17; A61K35/26; A61K35/545; A61K38/00; A61K39/00; A61K39/21; A61K48/00; A61P31/12; C07H21/04; C07K14/705; C07K14/725; C07K14/73; C07K14/735; C07K19/00; C12N5/10; C12N9/12; (IPC1-7): C12N15/09; A61K35/12; A61K35/14; A61K35/26; A61K38/00; A61K39/00; A61K39/21; A61K48/00; C07H21/04; C12N5/10
Attorney, Agent or Firm:
清水 初志