【発明の名称】トリアゾリルトリプタミンのパラジウム触媒閉環

Title:

【発明の名称】トリアゾリルトリプタミンのパラジウム触媒閉環

Document Type and Number:

Japanese Patent JPH10500680

Kind Code:

A

Abstract:

A new process is described for the synthesis of the triazolyl tryptamine: and related compounds. The process involves a palladium-catalyzed ring closure between a substituted ortho-iodoaniline and a protected 1-alkynol. The process is carded out at high temperature, e.g. 100 DEG C., in a dry inert solvent, e.g., DMF and in the presence of a proton acceptor, e.g., Na2CO3 or a trialkylamine. The triazolyl tryptamine, as well as acid addition salts thereof, is a 5 HT1D receptor agonist having anti-migraine properties.

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Inventors:

Chen, Chen Wai
Larsen, Robert Day
Barthoven, Thomas Earl

Application Number:

JP53030995A

Publication Date:

January 20, 1998

Filing Date:

May 19, 1995

Export Citation:

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Assignee:

Merck End Company, Inc.

International Classes:

A61K31/41; A61K31/415; A61P9/00; C07D403/06; A61P25/04; A61P43/00; C07D521/00; (IPC1-7): C07D403/06; A61K31/41; A61K31/415

Attorney, Agent or Firm:

Yoshio Kawaguchi (3 outside)

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