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Patent Searching and Data


Title:
【発明の名称】トリアゾリルトリプタミンのパラジウム触媒閉環
Document Type and Number:
Japanese Patent JPH10500680
Kind Code:
A
Abstract:
A new process is described for the synthesis of the triazolyl tryptamine: and related compounds. The process involves a palladium-catalyzed ring closure between a substituted ortho-iodoaniline and a protected 1-alkynol. The process is carded out at high temperature, e.g. 100 DEG C., in a dry inert solvent, e.g., DMF and in the presence of a proton acceptor, e.g., Na2CO3 or a trialkylamine. The triazolyl tryptamine, as well as acid addition salts thereof, is a 5 HT1D receptor agonist having anti-migraine properties.

Inventors:
Chen, Chen Wai
Larsen, Robert Day
Barthoven, Thomas Earl
Application Number:
JP53030995A
Publication Date:
January 20, 1998
Filing Date:
May 19, 1995
Export Citation:
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Assignee:
Merck End Company, Inc.
International Classes:
C07D403/06; A61K31/41; A61K31/415; A61P9/00; A61P25/04; A61P43/00; C07D521/00; (IPC1-7): C07D403/06; A61K31/41; A61K31/415
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)