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Title:
【発明の名称】ヒドロキシルアミン誘導体及びメタロプロテイナーゼ阻害剤としてのその用途
Document Type and Number:
Japanese Patent JPH10500965
Kind Code:
A
Abstract:
PCT No. PCT/EP95/01955 Sec. 371 Date Nov. 2, 1996 Sec. 102(e) Date Nov. 2, 1996 PCT Filed May 23, 1995 PCT Pub. No. WO95/33709 PCT Pub. Date Dec. 14, 1995The invention provides hydroxylamine derivatives of formula (I) wherein A, R1, R2 and R3 have the significance given in the description, which are matrix metalloproteinase inhibitors and which also prevent TNF release. They are therefore useful for the control or prevention of degenerative joints diseases such as rheumatoid arthritis and osteoarthritis or for the treatment of invasive tumours, atherosclerosis or multiple sclerosis. They can be manufactured according to generally known methods.

Inventors:
ブロードハースト,マイケル・ジョン
ブラウン,ポール・アンソニー
ジョンソン,ウィリアム・ヘンリー
Application Number:
JP50026496A
Publication Date:
January 27, 1998
Filing Date:
May 23, 1995
Export Citation:
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Assignee:
エフ・ホフマン-ラ ロシュ アーゲー
International Classes:
C07D233/72; A61K31/16; A61K31/165; A61K31/415; A61K31/4166; A61P9/10; A61P35/00; A61P37/06; A61P43/00; C07C237/22; C07C239/18; C07C259/06; C07D233/74; C07D233/78; (IPC1-7): C07C259/06; A61K31/16; A61K31/165; A61K31/415; C07D233/72
Attorney, Agent or Firm:
津国 肇 (外3名)