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Patent Searching and Data


Title:
【発明の名称】合成リーダーペプチド配列類
Document Type and Number:
Japanese Patent JPH10501413
Kind Code:
A
Abstract:
The present invention relates to a DNA expression cassette comprising the following sequence: 5'-P-SP-LS-PS-*gene*-(T)i-3'wherein P is a promoter sequence, SP is a DNA sequence encoding a signal peptide, LS is a DNA sequence encoding a leader peptide of formula I: GinProIle(Asp/Glu)(Asp/Glu)X1(Glu/Asp)X2AsnZ(Thr/Ser)X3 (SEQ ID NO: 77) (I) wherein X1 is a peptide bond or a codable amino acid; X2 is a peptide bond, a codable amino acid or a sequence of up to 4 codable amino acids which may be the same or different; Z is a codable amino acid except Pro; and X3 is a sequence of from 4 to 30 codable amino acids which may be the same or different; PS is a DNA sequence encoding a processing site; *gene* is a DNA sequence encoding a polypeptide; T is a terminator sequence; and i is 0 or 1.

Inventors:
クイェルセン,トーマス ベルグルム
バド,クヌド
Application Number:
JP50150496A
Publication Date:
February 10, 1998
Filing Date:
June 16, 1995
Export Citation:
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Assignee:
ノボ ノルディスク アクティーゼルスカブ
International Classes:
C12N15/09; C07K14/62; C12N1/19; C12N15/62; C12N15/81; C12P21/02; C12R1/865; (IPC1-7): C12N15/09; C12P21/02; C12N1/19
Attorney, Agent or Firm:
石田 敬 (外3名)