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Patent Searching and Data

Document Type and Number:
Japanese Patent JPH10513195
Kind Code:
PCT No. PCT/SI96/00002 Sec. 371 Date Jul. 28, 1997 Sec. 102(e) Date Jul. 28, 1997 PCT Filed Feb. 6, 1996 PCT Pub. No. WO96/24614 PCT Pub. Date Aug. 15, 1996The present invention discloses a new method for the purification of vancomycin hydrochloride by preparative HPLC (method of displacement chromatography), whereby the chromatographic purity of the product is essentialy improved. The chromatography is performed on a reverse stationary phase with a mobile phase consisting of an organic or inorganic acid or of a buffer with possible additives, with different displacing agents, at a defined pH and temperature as well as the amount and concentration of vancomycin hydrochloride. The process is distinguished by the excellent yield and exceptional chromatographic purity 95.5% area of the obtained product and, besides, it represents an ecologically irreproachable process. The vancomycin hydrochloride purified according to the present invention is useful for all types of application since the portion of impurities it contains is for one third lower than in hitherto known commercially available products.

Grahetsk, Rock
Bastarda, Andrei
Application Number:
Publication Date:
December 15, 1998
Filing Date:
February 06, 1996
Export Citation:
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Letsk Tovarna Fuarma Cebu Tosky in Chemiknie Ijerkov Day. Day.
International Classes:
C07K1/16; C07K9/00; A61K38/00; G01N30/02; (IPC1-7): C07K9/00; C07K1/16
Attorney, Agent or Firm:
Shigeru Yagita (2 outside)