Title:
【発明の名称】カルシトリオール誘導体およびそれらの用途
Document Type and Number:
Japanese Patent JPH11511475
Kind Code:
A
Abstract:
A method of treating metabolic bone diseases such as osteoporosis, as well as other disease states treatable with vitamin D compounds, comprises administering an effective amount of one or more modified vitamin D compounds. The modified compound contains a typical vitamin D nucleus but with in vivo hydrolyzable groups at one or more of the 1, 3 and 25 carbon positions. The time of conversion of the modified compound to its active form, such as calcitriol, can be regulated to thus provide controlled release of the compound in vivo over time, by changing or modifying the hydrolyzable groups.
Inventors:
Deluca, Hector Ef
Schnoes, Heinrich Kay
Kai, Zi Yang
Phelps, Mary Yee
Smith, Connie M
Schnoes, Heinrich Kay
Kai, Zi Yang
Phelps, Mary Yee
Smith, Connie M
Application Number:
JP51294597A
Publication Date:
October 05, 1999
Filing Date:
September 20, 1996
Export Citation:
Assignee:
WISCONSIN ALUMNI RESEARCH FOUNDATION
International Classes:
A61K31/00; A61P3/00; A61P3/02; A61K31/59; A61P7/00; A61P19/00; A61P19/08; C07C401/00; (IPC1-7): C07C401/00; A61K31/00; A61K31/59
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)