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Document Type and Number:
Japanese Patent JPS50100033
Kind Code:
A
Abstract:
The process for the preparation of D-xylofuranose derivatives of the formula I in which R<2> is a benzyl group which is optionally substituted in the side chain comprises exposing 5-O-tosyl-D-xylofuranose derivatives of the formula V in which R<3> is hydrogen, an alkyl group with 1-4 carbon atoms or an aryl group, R<4> is hydrogen or an alkyl group with 1-4 carbon atoms, or else R<3> and R<4> together are an alkylene bridge with 4-6 members, at room temperature to the simultaneous action of compounds of the formulae R1OH and R1ONa, where R1 is an aliphatic radical with 1-4 C atoms, isolating the 3,5-anhydro-D-xylofuranose derivative of the formula IV which is formed, and exposing the compounds of the formula IV or compounds of the formula V to the simultaneous action of compounds of the formulae R2OH and R2ONa, isolating the 5-O-R<2>-D-xylofuranose derivatives of the formula III as such or in the form of their adducts, and reacting them in the presence of acid catalysts with compounds of the formula R1OH, subsequently isolating the D-xylofuranosides of the formula II which are formed, and converting the compounds of the formula II or the D-xylofuranose derivatives of the formula III by reaction with dilute mineral acids into the D-xylofuranose derivatives of the formula I and isolating the latter. The compounds of the formula I have activity against venous disorders and furthermore have an antiinflammatory action.

Application Number:
JP14582274A
Publication Date:
August 08, 1975
Filing Date:
December 20, 1974
Export Citation:
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International Classes:
C07H9/04; C07H15/18; (IPC1-7): C07H3/02
Domestic Patent References:
JP46034405A
JPS4739075A



 
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