GENETIC COMPONENT OF COMPLICATIONS IN TYPE 2 DIABETES

[001] This application claims the benefit of U.S. provisional Application No. 61/061,389, filed on June 13, 2008, the disclosure of which is incorporated herein by reference in its entirety.

[002] The invention provides means and methods to predict, in subjects affected by type II diabetes (T2D), the probability of developing complications related to the disease.

[003] The invention further provides with methods for characterizing and selecting, within a population of subjects with type II diabetes (T2D), subjects that are suited for clinical trials based on the identification of one or more genetic features, which are single nucleotide polymorphisms (SNPs), short tandem repeats (STRs) and/or other genomic markers in addition to the currently used biological markers of high cardiovascular risk.. The invention further involves characterizing these subjects based on the probability of developing complications related to T2D, such as, myocardial infarction, stroke albuminuria and/or declining glomerular filtration. Also described are combinations and kits for carrying out the above-described methods.

[004] Diabetes mellitus is a heterogeneous group of metabolic diseases which is characterized by elevated blood glucose levels and increased morbidity. The endocrine cells of the pancreas which synthesize insulin and other hormones are involved in the pathogenesis of diabetes. Both genetic and environmental factors contribute to its development. The most common form is T2D, which is characterized by defects in both insulin secretion and insulin action. In contrast, type I diabetes results from autoimmune destruction of the insulin-producing beta cells of the pancreas. Monogenic forms of diabetes account for less than 5% of the cases and are usually caused by mutations in genes associated with maturity-onset diabetes of the young (MODY), insulin gene and insulin receptor gene.

[005] T2D is a heterogeneous disease resulting from the interaction of environmental factors such as obesity or sedentary lifestyle, with variety of diabetogenic genes. Abnormal glucose homeostasis occurs when either insulin sensitivity or insulin secretion or both are altered. An early finding in this development is insulin resistance, defined as impaired insulin-mediated glucose clearance in insulin-sensitive tissues (skeletal muscle, liver and adipose tissue). Elevation of glucose levels triggers beta-cells to produce and secrete more insulin, which compensates for the disturbance in glucose homeostasis. The duration of hyperglycemia-hyperinsulinemia state

depends on insulin secretory capacity, mass and apoptosis rate of beta-cells. Furthermore, beta- cells can loose their insulin secretion capacity because of glucose toxicity or other reasons. When cells fail to compensate for insulin resistance blood glucose concentration increases. Thus, over time subclinical hyperglycemia tends to progress to impaired glucose tolerance and further to T2D.

[006] The causes of T2D are multi-factorial and include both genetic and environmental elements that affect beta cell function and insulin sensitivity of peripheral tissues (muscle, liver, adipose tissue, pancreas). Although there is considerable debate as to the relative contributions of beta-cell dysfunction and reduced insulin sensitivity to the pathogenesis of diabetes, it is generally agreed that both of these factors play important roles. Both impaired insulin secretion and insulin action cause the development of T2D. Insulin resistance is an early feature in the pathophysiology of T2D.

[007] No major single gene explaining the development of T2D has been identified. There were several studies attempting to predict T2D based on limited number of SNPs (up to 18) [Lyssenko, V, P Almgren, D Anevski et al.: Genetic prediction of future type 2 diabetes. PLoS Med 2, e345 (2005); Meigs, JB, P Shrader, LM Sullivan et al: Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med 359, 2208-19 (2008); Cauchi, S, D Meyre, E Durand et al.: Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value. PLoS ONE 3, e2031 (2008). Miyake, K, W Yang, K Hara et al.: Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. / Hum Genet 54, 236-41 (2009); Lin, X, K Song, N Iim et al.: Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score— the CoLaus Study. Diabetologia 52, 600-8 (2009)] but the reached predictive power was generally limited. Indeed, the mathematical models reflecting the presumable allele frequencies and risk effects estimate that for successful prediction, hundreds of SNPs will be necessary [(Kraft, P,DJ Hunter: Genetic Risk Prediction -- Are We There Yet? N Engl J Med 360, 1701-1703 (2009)].

[008] Complications associated with diabetes

[009] Over 90% of people diagnosed with diabetes have T2D, which carries a number of potential complications. These complications currendy add very significandy to the cost of treating diabetes, because there is no reliable way to determine which patients are likely to

develop such difficulties. Half of the people affected by T2D die from complications resulting from the disease.

[010] Such complications include, but are not limited to:

[Oil] Cardiovascular Disease

[012] Cardiovascular disease is the overwhelming cause of diabetes-related deaths. With the risk for stroke or myocardial infarction elevated by 2 to 4 times in persons with diabetes, a 65% majority of deaths among people with diabetes occurs from heart disease or stroke, considered as major macrovascular complications.

[013] Diabetic Nephropathy

[014] End-stage renal disease (ESRD) occurs when the kidneys cease to function, which ultimately leads to the need for a transplant or regular dialysis, both extremely costly procedures. Diabetes is responsible for 43% of the cases of ESRD as a consequence of microvascular damage of the kidney.

[015] Diabetic Retinopathy

[016] Diabetes is also the leading cause of blindness in people aged 20-74. Diabetic retinopathy is considered as one type of microvascular complication and is responsible for over 24,000 cases of blindness in the United States.

[017] Diabetic Neuropathy

[018] It is estimated that over 70% of people with diabetes may also suffer from nervous system damage, causing impaired sensation or pain in the feet or hands, slowed digestion of food in the stomach, carpal tunnel syndrome, and other nerve problems. In the severe cases of diabetic neuropathy, usually combined with peripheral vessel macro and microvascular disease, patients may have to undergo lower-extremity amputations.

[019] Dental disease, complications of pregnancy, coma, and acute susceptibility to opportunistic infectious diseases are also costly diabetes-related diseases.

[020] Drugs designed to prevent or stabilize complications are extremely costly. Because of the debilitating effects of diabetes-related complications, healthcare professionals are forced to

prescribe costly medications to diabetes patients to protect them against developing these complications without having any efficient and reliable mean to predict those patients who will develop these complications and the efficiency of these treatments.

[021] There is a need for assays capable of identifying among T2D patients those who are at risk of developing complications and those who would benefit from the various treatments available. The present invention provides with means to develop such assays and to utilize them in a clinical and medical environment.

[022] Polymorphisms

[023] DNA polymorphisms provide an efficient way to study the association of genes and diseases by analysis of linkage and linkage disequilibrium. With the sequencing of the human genome a myriad of hitherto unknown genetic polymorphisms among people have been detected. Most common among these are the single nucleotide polymorphisms, also called SNPs, of which there are known several millions. Other examples are short tandem repeat polymorphisms (STR), variable number of tandem repeat polymorphisms (VNTR), insertions, deletions and block modifications. Tandem repeats (STR or VNTR) often have multiple different alleles (variants) in population, whereas the other groups of polymorphisms usually have just two alleles. Some of these genetic polymorphisms play a direct role in the biology of the individuals, including their risk of developing disease, but the virtue of the majority is that they can serve as markers for the surrounding DNA. The relationship of an allele of one sequence polymorphism with particular alleles of other sequence polymorphisms in the surrounding is due to phenomenon called genetic linkage. Linkage arises because large parts of chromosomes are passed unchanged from parents to offspring, so that minor regions of a chromosome tend to flow unchanged from one generation to the next and also to be similar in different branches of the same family. Linkage is gradually eroded by recombination occurring in the germline cells, but typically operates over multiple generations and distances of a number of million bases in the DNA.

[024] Linkage disequilibrium deals with whole populations and has its origin in the (distant) forefather in whose DNA a new sequence polymorphism arose. The immediate surroundings in the DNA of the forefather will tend to stay with the new allele and propagate together to the offspring for many generations. Recombination and changes in the composition of the population will again erode the association, but the new allele and the alleles of any other

polymorphism nearby will often be partly associated among unrelated humans even today. A crude estimate suggests that alleles of sequence polymorphisms with distances less than 10000 bases in the DNA will have tended to stay together since modern man arose. Linkage disequilibrium in limited populations, for instance Europeans, often extends over longer distances, e.g. over more than 1 ,000,000 bases. This can be the result of newer mutations, but can also be a consequence of one or more "bottlenecks" with small effective population sizes and considerable inbreeding in the history of the current population. Two obvious possibilities for "bottlenecks" in Europeans are the exodus from Africa and the repopulation of Europe after die last ice age. A number of polymorphisms have been associated with induction of exocrine pancreatic dysfunction and/or diabetes. Some of the identified polymorphisms have been suggested in patent literature as useful in diagnosis of diabetes (see for example WO9321343 related to polymorphisms in GCK gene, and WO0023591 related to polymorphism in ZSIG49 gene).

[025] Up to date, several genomic regions or individual genetic variants have been found to be linked or associated to the phenotypes closely related to diabetic complications.

[026] Linkage studies

[027] In a recent study (Diabetes. 2008 Jan;57(l):235-43), a genome-wide scan for estimated glomerular filtration rate was performed in multi-ethnic diabetic populations (the Family Investigation of Nephropathy and Diabetes (FIND)) using 404 STR markers. For all ethnicities combined, strong evidence for linkage was observed on chromosomes Iq43, 7q36.1, 8ql3.3 and 18q23.3. Mexican-American families, who comprised the major ethnic subpopulation in FIND, contributed to linkage on chromosomes Iq43, 2pl3.3, 7q36.1, 8ql3.3, and 18q23.3, whereas African-American and American-Indian families displayed linkage peaks on chromosomes Ilpl5.1 and 15q22.3, respectively. Also in FIND study (Diabetes. 2007 Jun;56(6):l 577-85), the strongest evidence of linkage to the diabetic nephropathy trait was on chromosomes 7q21.3, 10pl5.3, 14q23.1, and 18q22.3. In ACR (883 diabetic sibling pairs), the strongest linkage signals were on chromosomes 2ql4.1, 7q21.1, and 15q26.3. These results confirm regions of linkage to diabetic nephropathy on chromosomes 7q, 1Op, and 18q from prior reports. In Mexican Americans, Puppala al. (Diabetes. 2007 Nov;56 (ll):2818-28) found a linkage of glomerular filtration rate to a region on chromosome 2q near marker D2S427 (corrected LOD score 3.3), influenced by genotype by diabetes interaction.

[028] Association studies

[029] A number of genes and genetic polymorphisms were tested for their association to diabetic nephropathy, either because of their reported relevance in metabolic and signaling pathways connected to pathophysiology of diabetic complications (functional candidates) or combination of the former with their genomic position under peak of ascertained linkage (positional candidates), or as a result of genome-wide association studies. Genes for which an association was found with diabetic nephropathy include 5,10-methylenetetrahydrofolate reductase (MTHFR), natriuretic peptide precursor A (NPPA), solute carrier family 2 member 1 (facilitated glucose transporter SLC2A1), lamin A/C (LMNA), retinoid X receptor gamma (RXRG), interleukin 1 receptor antagonist (ILlRN), ghrelin/obestatin preprohormone (GHRL), peroxisome proliferator-activated receptor gamma (PPARG), chemokine receptor 5 (CCR5), angiotensin II receptor type 1 (AGTRl), solute carrier family 2 member 2 (facilitated glucose transporter SLC2A2), adiponectin (ADIPOQ), fatty acid binding protein 2 (FABP2), glutamine- fructose-6-phosphate transaminase 2 (GFPT2), advanced glycosylation end product-specific receptor (AGER), lymphotoxin alpha (LTA), vascular endothelial growth factor A (VEGF), ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPPl), SMT3 suppressor of mif two 3 homolog 4 (small ubiquitin-like modifier 4 protein SUMO4), estrogen receptor 1 (ESRl), superoxide dismutase 2 (SOD2), neuropeptide Y (NPY), engulfment and cell motility 1 (ELMOl), insulin-like growth factor binding protein 1 (IGFBPl), epidermal growth factor receptor (EGFR), paraoxonase 1 (PONl), aldo-keto reductase family 1, member Bl (AKRlBl), caldesmon 1 (CALDl), nitric oxide synthase 3 (NOS3), lipoprotein lipase (LPL), Pvtl oncogene homolog MYC activator (PVTl), insulin (INS), xylosyltransferase I (XYLT), protein kinase C beta 1 (PRKCBl), solute carrier family 12 (SLC12A3), haptoglobin (HP), chemokine ligand 2 (CCL2), angiotensin I converting enzyme (ACE), meprin A, beta (MEPlB), carnosine dipeptidase 1 (CNDPl), intercellular adhesion molecule 1 (ICAMl), transforming growth factor beta 1 (TGFBl), apolipoprotein E (APOE) and superoxide dismutase 1 (SODl), CD48 molecule (CD48), solute carrier family 35, member F3 (SLC35F3), endothelial PAS domain protein 1 (EPASl), low density lipoprotein-related protein IB (deleted in tumours) (LRPlB), dynein, axonemal, heavy chain 7 (DNAH7), ADAM metallopeptidase domain 23 (ADAM23), leprecan-likel (LEPRELl), human immunodeficiency virus type I enhancer binding protein 2 (HIVεP2), thrombospondin, type I, domain containing 7A (THSD7A), S-adenosylhomocysteine hydrolase-like 2 (AHCYL2), discs, large homolog 2 (Drosophila) (DLG2), FYVE, RhoGEF and PH domain containing 4 (FGD4), rabphilin 3A homolog (mouse) (RPH3A), citrate lyase beta like (CLYBL), protein kinase C, eta (PRKCH), epidermal growth factor receptor pathway

substrate 15-like 1 (EPSl 5Ll), cystatin 9 (testatin) (CST9), pericentrin (PCNT2), matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV colkgenase) (MMP9), apolipoprotein C-I (APOCl), cysteinyl-tRNA synthetase (CARS), chimerin (chimaerin) 2 (CHN2), neurocalcin delta (NCALD), ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPPl), major histocompatibility complex, class II, DR beta 1 (HLA-DRBl), interleukin 8 (IL8), pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 (PLEKHH2), angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (AGT) and others, reviewed in Maeda, S: Genetics of diabetic nephropathy. Ther Adv Cardiovasc Dis 2, 363-71 (2008).

[030] Genes and markers in type-2 diabetes and obesity are described in US patent application publication No. 2007-0292412 to Salonen et al.

[031] Proteomic studies

[032] Few proteomic studies have been so far conducted with the aim of identifying biomarkers of predictive value for diabetic nephropathy. Otu et al. (Diabetes Care (2007) 30:638- 543) (WO 2007/056587) performed a nested case-control study on Pima Indians that allowed for identification of a 12-peak proteomic signature that was validated on a small number of individuals. However, the study did not permit the identification of the proteins from which these peaks belong and replication in other populations is needed prior to concluding the broad applicability of these biomarkers.

Up to date, there have been dozens of genetic variants and genome regions associated or linked to myocardial infarction, both in T2D patients as well as in non-diabetics. These have been comprehensively reviewed recently (Yamada, Y, S Ichihara.T Nishida: Molecular genetics of myocardial infarction. Genomic Med 2, 7-22 (2008)) and specifically for genome-wide association studies in A Catalog of Published Genome-Wide Association Studies by The National Human Genome Research Institute (available on the world wide web at genome.gov/26525384) Johnson, AD ,CJ O'Donnell: An open access database of genome-wide association results. BMC Med Genet 10, 6 (2009).

SUMMARY OF THE INVENTION

[033] The present invention relates to previously unknown associations between T2D-related complications and various polymorphisms, genes and loci. These associated polymorphisms, genes, and loci provide basis for novel methods and kits for risk assessment, diagnosis and

prognosis of T2D-related complication in a patient, among other things. In addition these polymorphisms, genes, and loci provide basis for methods and kits for novel therapies to prevent, treat and/ or reduce risk of developing these complications.

[034] A "biomarker" in the context of the present invention refers to a genetic feature such as, for example, single nucleotide polymorphism (SNP) or a short tandem repeat (STR). Other types of biomarkers include, but are not limited to, transcriptional products (such as, for example, mRNA or cDNA sequences thereof) or translational products (such as, for example, proteins or polypeptides) of genes comprising such SNPs. Representative examples of such SNPs are disclosed in Table 1, 4, 7, 10, 13, 14, 16 and 19. Polymorphic genes of the present invention comprise the genes/loci also disclosed in Table 3, 6, 9 and 12. A "biomarker" can also be a clinical or biological biomarker. Clinical or biological biomarkers include, but are not limited to, age, sex, glucose levels, age of diagnosis, diabetes duration at baseline, cigarette smoking, diastolic or systolic blood pressure, atrial fibrillation, glycated hemoglobin (HbAI _j ), total cholesterol, HDL cholesterol, albumin/creatinine ratio, glomerular filtration rate.

[035] In one embodiment, the biomarker is one of the SNPs listed in Table 1, 4, 7, 10, 13, 14, 16 and 19 or a SNP or a STR found to be in linkage disequilibrium to one of the SNP listed in Table 1, 4, 7, 10, 13, 14, 16 and 19.

[036] Preferably, the biomarker is not a SNP listed in Table 20.

[037] In another embodiment, the biomarker is a SNP of at least one of the genes listed in table 3, 6, 9 and 12 or a STR linked to a SNP of at least one of these above genes or to a locus closely related thereto.

[038] Preferably, the biomarker is not an SNP of a gene which is listed in Table 21.

[039] The present invention thus provides for methods of predicting risk of complications associated with T2D, comprising detecting at least one of the SNPs listed in Table 1, 4, 7, 10, 16 and 19 or a SNP or a STR found to be in linkage disequilibrium with one or more of the SNPs listed in Table 1, 4, 7, 10, 16 and 19, or a SNP of at least one gene listed in Table 3, 6, 9 and 12 or a SNP or a STR found to be in linkage disequilibrium with a SNP of such a gene, wherein the presence of the SNP or STR in a sample of a subject (or patient) suffering from T2D indicates

that said subject (or patient) is likely to develop the complication. Preferred examples of such complications include, but are not limited to, albuminuria and /or declining glomerular filtration, myocardial infarction, and/or stroke.

[040] As used herein, "single nucleotide polymorphism," or "SNP" is a DNA sequence variation that occurs when a nucleotide, e.g., adenine (A), thymine (T), cytosine (C), or guanine (G), in the genome sequence is altered to another nucleotide. SNPs are occasional variations in DNA sequence; the vast majority of the DNA sequence is identical among all humans. SNPs or other variants may also be found in genomic regions that do not contain genes. They represent a genomic hot spot responsible for the genetic variability among humans.

[041] As used herein, "gene" means any amount of nucleic acid material that is sufficient to encode a transcript or protein having the function desired. Thus, it includes, but is not limited to, genomic DNA, cDNA, RNA, and nucleic acid that are otherwise genetically engineered to achieve a desired level of expression under desired conditions. Accordingly, it includes fusion genes (encoding fusion proteins), intact genomic genes, and DNA sequences fused to heterologous promoters, operators, enhancers, and/or other transcription regulating sequences. Methods and nucleic acid constructs for preparing genes for recombinant expression are well known and widely used by those of skill in the art, and thus need not be detailed here. The term refers to an entirety containing entire transcribed region and all regulatory regions of a gene. The transcribed region of a gene including all exon and intron sequences of a gene including alternatively spliced exons and introns so the transcribed region of a gene contains in addition to polypeptide encoding region of a gene also regulatory and 5' and 3' untranslated regions present in transcribed RNA.

[042] The genes of the invention are listed in Table 3, 6, 9 and 12.

[043] Preferably, the gene is not one of the genes listed in Table 21.

[044] As used herein, an "exon" is a segment of a eukaryotic gene that encodes a sequence of nucleotides in mRNA. An exon can encode amino acids in a protein. Exons are generally adjacent to introns.

[045] As used herein, an "intron" is a non-coding region of a eukaryotic gene that may be

transcribed into an RNA molecule, but is not usually translated into amino acids. It may be excised by RNA splicing when mRNA is produced.

[046] As used herein, a "patient" is any living animal, including, but not limited to, a human who has, or is suspected of having or being susceptible to, a disease or disorder, or who otherwise would be a subject of investigation relevant to a disease or disorder. Accordingly, a patient can be an animal that has been bred or engineered as a model for metabolic syndrome, type 2 diabetes, obesity, hypertension, atherosclerosis, or any other disease or disorder. Likewise it can be a human suffering from, or at risk of developing, a disease or disorder associated with insulin metabolism, or any other disease or disorder. Similarly, a patient can be an animal (such as an experimental animal, a pet animal, a farm animal, a dairy animal, a ranch animal, or an animal cultivated for food or other commercial use), or a human, serving as a healthy control for investigations into diseases and/or disorders, e.g., those associated with insulin metabolism.

[047] By "reagent," is meant any element, molecule, or compound that is present in the assay system and participates, either directly or indirectly, in the biochemical processes occurring during the performance of the method. Reagents include, but are not limited to, nucleic acids, cells, media, chemicals, compounds used to introduce nucleic acids into cells, and compounds used to generate detectable signals.

[048] By "materials" is meant items that are used to contain and/or perform the methods of the invention, but that do not participate in any of the biochemical reactions taking place in the method. Materials include, but are not limited to, test tubes, pipettes, gels, and ultraviolet transilluminators.

[049] A "haplotype," as described herein, refers to any combination of genetic markers ("alleles") usually inherited together. A haplotype can comprise two or more alleles and the length of a genome region comprising a haplotype may vary from few hundred bases up to hundreds of kilobases. As it is recognized by those skilled in the art, the same haplotype can be described differently by determining the haplotype defining alleles from different nucleic acid strands. For example, the haplotype GGC defined by the SNP markers of this invention is the same as haplotype CCG in which the alleles are determined from the other strand, or haplotype CGC, in which the first allele is determined from the other strand. The haplotypes described herein are differentially present in T2D patients with increased risk of developing one or more of

the aforementioned complications. Therefore, these haplotypes have diagnostic value for risk assessment, diagnosis and prognosis of T2D-related complications. Detection of haplotypes can be accomplished by methods known in the art used for detecting nucleotides at polymorphic sites.

[050] A nucleotide position in genome at which more than one sequence is possible in a population, is referred to herein as a "polymorphic site" or "polymorphism". Where a polymorphic site is a single nucleotide in length, the site is referred to as a SNP. For example, if at a particular chromosomal location, one member of a population has an adenine and another member of the population has a cytosine at the same position of his or her paternal or maternal DNA molecule, then this position is a polymorphic site, and, more specifically, the polymorphic site is a SNP. Polymorphic sites may be several nucleotides in length due to insertions, deletions, conversions or translocations. Each version of the sequence with respect to the polymorphic site is referred to herein as an "allele" of the polymorphic site. Thus, in the previous example, the SNP allows for both an adenine allele and a cytosine allele. Typically, a reference nucleotide sequence is referred to for a particular polymorphism e.g. in NCBI databases (as accessible on the world- wide- web at ncbi.nlm.nih.gov). Alleles that differ from the reference are referred to as "variant" alleles. The polypeptide encoded by the reference nucleotide sequence is the "reference" polypeptide with a particular reference amino acid sequence, and polypeptides encoded by variant alleles are referred to as "variant" polypeptides with variant amino acid sequences. Nucleotide sequence variants can result in changes affecting properties of a polypeptide. These sequence differences, when compared to a reference nucleotide sequence, include insertions, deletions, conversions and substitutions: e.g. an insertion, a deletion or a conversion may result in a frame shift generating an altered polypeptide; a substitution of at least one nucleotide may result in a premature stop codon, amino acid change or abnormal mRNA splicing; the deletion of several nucleotides, resulting in a deletion of one or more amino acids encoded by the nucleotides; the insertion of several nucleotides, such as by unequal recombination or gene conversion, resulting in an interruption of the coding sequence of a reading frame; duplication of all or a part of a sequence; transposition; or a rearrangement of a nucleotide sequence, as described in detail above. Such sequence changes alter the polypeptide encoded by the genes comprising such SNPs. For example, a nucleotide change resulting in a change in polypeptide sequence can alter the physiological properties of a polypeptide dramatically by resulting in altered activity, distribution and stability or otherwise affect on properties of a polypeptide. Alternatively, nucleotide sequence variants can result in changes

affecting transcription of a gene or translation of its mRNA. A polymorphic site located in a regulatory region of a gene may result in altered transcription of a gene e.g. due to altered tissue specificity, altered transcription rate or altered response to transcription factors. A polymorphic site located in a region corresponding to the mRNA of a gene may result in altered translation of the mRNA e.g. by inducing stable secondary structures to the mRNA and affecting the stability of the mRNA. Such sequence changes may alter the expression of a susceptibility gene, such as, for example, an SNP associated with the aforementioned genes.

[051] The SNP markers of the present invention, which are disclosed in tables 1, 4, 7, 10, 13, 14, 16 and 19 have been denoted with their official reference SNP (rs) ID identification tags assigned to each unique SNP by the National Center for Biotechnological Information (NCBI). Each rs ID has been linked to specific variable alleles present in a specific nucleotide position in the human genome, and the nucleotide position has been specified with the nucleotide sequences flanking each SNP.

[052] Although the numerical chromosomal position of a SNP may still change upon annotating the current human genome build the SNP identification information such as variable alleles and flanking nucleotide sequences assigned to a SNP will remain the same. Those skilled in the art will readily recognize that the analysis of the nucleotides present in one or more SNPs set forth in table 1, 4, 7, 10, 13, 14, 16 and 19 of this invention in an individual's nucleic acid can be done by any method or technique capable of determining nucleotides present in a polymorphic site using the sequence information assigned in prior art to the rs IDs of the SNPs listed in table 1, 4, 7, 10, 13, 14, 16 and 19 of this invention. As it is obvious in the art the nucleotides present in polymorphisms can be determined from either nucleic acid strand or from both strands.

[053] In one embodiment, the invention relates to a method for predicting the risk of developing a complication which is albuminuria and /or declining glomerular filtration myocardial infarction, or stroke in a subject having T2D, comprising detecting in a sample obtained from said subject at least one SNP having an RefSNP ID listed in Table 1, 4, 7, 10, 16 or 19.

[054] In a related aspect, the present invention relates to a method for predicting the risk of developing a complication which is either myocardial infarction, or stroke or albuminuria and

/or declining glomerular filtration or any combination thereof in a subject having T2D, comprising detecting at least one SNP having an RefSNP ID listed of in Table 1, 4, 7, 10, 16 or 19.

[055] In a related aspect, the present invention relates to a method for predicting the risk of developing a complication which is albuminuria and /or declining glomerular filtration myocardial infarction, or stroke in a subject having T2D, comprising detecting in a sample obtained from said subject at least one SNP having an RefSNP ID listed in Table 1, 4, 7, 10, 16 or 19, wherein said RefSNP ID is not one of the SNPs listed in Table 20.

[056] Determination of Repeated Sequences

[057] The present invention also provides a method for prognosticating T2D-related complication in a subject comprising detecting short tandem repeats (STR) in linkage disequilibrium with a SNP listed in Table 1, 4, 7, 10, 16 or 19. The present invention thus provides for methods of predicting risk of complication associated with T2D, comprising detecting at least one STR found to be in linkage disequilibrium with one of the SNPs of the present invention, wherein the presence of the STR in a sample of a subject (or patient) suffering from T2D indicates that said subject (or patient) is likely to develop the complication. Preferred examples of such complications include, but are not limited to, albuminuria and /or declining glomerular filtratrion myocardial infarction, and/or stroke. Methods for determining the presence of repeated sequences in a nucleic acid sample (for example, genomic DNA) are known in the art.

[058] As such, in a related embodiment, the present invention provides a method for prognosticating type 2 diabetes-related complication in a subject comprising detecting single tandem repeats (STR) in a nucleic acid target sequence, wherein such target sequences are contained in at least one gene from the aforementioned gene set or a locus related thereto. The nucleotide sequences contained in the genes and/or a locus related thereto are obtainable from the GENEID and/or OMIM accession numbers.

[059] Geo-ethnic specificity. Given the density of the currendy available genomic markers, it was possible to distinguish without any overlap Caucasians, Africans and Asians. However, the heterogeneity within Caucasians was not described prior to the initial filing date of die present patent application. Since then there has been several papers published describing the use of

genetic variation for determination of geoethnic characteristics of an individual, e.g. Novembre, J, T Johnson, K Bryc et a/.: Genes mirror geography within Europe. Nature 456, 98-101 (November 6, 2008); Paschou, P, P Drineas, J Lewis et a/.: Tracing sub-structure in the European American population with PCA-informative markers. PLoS Genet 4, el 000114 (July 4, 2008); McEvoy, BP, GW Montgomery, AF McRae et a/.: Geographical structure and differential natural selection among North European populations. Genome Res 19, 804-14 (2009). The present invention identified a composite of 14839 SNPs unrelated to complications (listed in Table 13), which allowed us to distinguish three sub-populations within Caucasians of European descent Two of those are predominant with a west/east cline in Europe. The west type includes individuals from Ireland, Netherlands, United Kingdom but also a majority of people from Australia, Canada and New-Zealand (see figure 2). East type includes population from Russia, Estonia, Poland, Slovakia, Czech Republic and Hungary with German being populated by both geo-ethnic groups. In addition, Caucasians in Australia, Canada and New-Zealand include a significant admixture of the Eastern type. We have also identified a third group present as a minority in most of countries studied. Further refinement of the method allowed for identification of a composite of as few as 2 000 SNPs permitting the same (Table 14).

[060] The geo-ethnic specificity has to be taken into account for the development of predictive tools based on genomic signatures which, as exemplified in Figure 4, can result in higher/lower frequency of risk/protective alleles or difference in penetrance.

[061] It is understood that die SNP markers of this invention may be associated with other polymorphisms. This allows for tagging SNPs (tagSNPs), which comprise loci that can serve as proxies for many other SNPs. The use of tagSNPs greatly improves the power of association studies as only a subset of loci needs to be genotyped while maintaining the same information and power as if one had genotyped a larger number of SNPs.

[062] By using the name of the aforementioned gene provided in Table 3, 6, 9 and 12 those skilled in the art will readily find the nucleotide sequences of a gene and the mRNAs encoded thereby as well as amino acid sequences the encoded polypeptides.

[063] In certain methods described herein, an individual who is at risk for a T2D-related complication is an individual in whom one or more SNPs selected from the Table 1, 4, 7, 10, 16 and 19 are identified. In other embodiment also polymorphisms or haplotypes associated to

SNPs of the tables may be used in risk assessment of a T2D-related complication. The significance associated with an allele or a haplotype is measured by an odds ratio. In a further embodiment, the significance is measured by a percentage. In one embodiment, a significant risk is measured as odds ratio of 0.9 or less or at least about 1.1, including by not limited to: 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.5, 3.0, 4.0, 5.0, 10.0, 15.0, 20.0, 25.0, 30.0 and 40.0. In a further embodiment, a significant increase or reduction in risk is at least about 10%, including but not limited to about 10%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95% and 99%. In a further embodiment, a significant increase in risk is at least about 50%. It is understood however, that identifying whether a risk is medically significant may also depend on a variety of factors such as family history of hypertension, history of gestational diabetes, previously identified glucose intolerance, obesity, hypertriglyceridemia, hypercholesterolemia, elevated LDL cholesterol, low HDL cholesterol, elevated blood pressure (BP), cigarette smoking, lack of physical activity, and inflammatory components as reflected by increased C-reactive protein levels or other inflammatory markers.

[064] "Probes" or "primers" are oligonucleotides that hybridize in a base-specific manner to a complementary strand of nucleic acid molecules. By "base specific manner" is meant that the two sequences must have a degree of nucleotide complementarity sufficient for the primer or probe to hybridize to its specific target. Accordingly, the primer or probe sequence is not required to be perfectly complementary to the sequence of the template. Non-complementary bases or modified bases can be interspersed into the primer or probe, provided that base substitutions do not inhibit hybridization. The nucleic acid template may also include "nonspecific priming sequences" or "nonspecific sequences" to which the primer or probe has varying degrees of complementarity. Probes and primers may include modified bases as in polypeptide nucleic acids. Probes or primers typically comprise about 15 to 30 consecutive nucleotides present e.g. in human genome and they may further comprise a detectable label, e.g., radioisotope, fluorescent compound, enzyme, or enzyme co-factor. Probes and primers to a SNP marker disclosed in table 1, 4, 7, 10, 16 and 19 are available in the art or can easily be designed using the flanking nucleotide sequences assigned to a SNP rs ID and standard probe and primer design tools.

[065] Primers and probes for SNP markers disclosed in Table 1, 4, 7, 10, 16 and 19 can be used in risk assessment as well as molecular diagnostic methods and kits of this invention.

[066] The invention comprises polyclonal and monoclonal antibodies that bind to a polypeptide encoded by a gene listed in table 3, 6, 9 or 12 or comprising a SNP set forth in Table 1, 4, 7, 10, 16 or 19 of the invention. The term "antibody" as used herein refers to immunoglobulin molecules or their immunologically active portions that specifically bind to an epitope (antigen, antigenic determinant) present in a polypeptide or a fragment thereof, but does not substantially bind other molecules in a sample, e.g., a biological sample, which contains the polypeptide. Examples of immunologically active portions of immunoglobulin molecules include F(ab) and F(ab') ₂ fragments which can be generated by treating the antibody with an enzyme such as pepsin. The term "monoclonal antibody" as used herein refers to a population of antibody molecules that are directed against a specific epitope and are produced either by a single clone of B cells or a single hybridoma cell line. Polyclonal and monoclonal antibodies can be prepared by various methods known in the art. Additionally, recombinant antibodies, such as chimeric and humanized monoclonal antibodies, comprising both human and non-human portions, can be produced by recombinant DNA techniques known in the art. Antibodies can be coupled to various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, or radioactive materials to enhance detection.

[067] In a related embodiment, the present invention also provides for the use of antisense oligonucleotides or silencing RNAs or similar methods which are capable of modulating the expression and/or levels of a product (i.e., mRNA or polypeptide) of a gene comprising a SNP set forth in Table 1, 4, 7, 10, 16 or 19. In a particularly preferred embodiment, the antisense molecules silencing RNAs or similar methods of the present invention are useful directed against the primary transcript (i.e., mRNA) of the genes listed in Table 3, 6, 9 and 12 or comprising a SNP set forth in Table 1, 4, 7, 10, 16 or 19. Techniques for the design and use of antisense molecules or silencing RNAs or similar methods, for example, in in vitro and/or in vivo applications, are known in the art.

[068] "A T2D-related complication" in the context of this invention refers to glucose intolerance, insulin resistance, metabolic syndrome, obesity, a microvascular complication of T2D such as retinopathy, nephropathy or neuropathy, or a macrovascular complication such as coronary heart disease, cerebrovascular disease, congestive heart failure, claudication or other clinical manifestation of atherosclerosis or arteriosclerosis.

[069] Preferred types of "T2D-related complications" include, but are not limited to, cardiovascular diseases, retinopathy, neuropathy, and/or nephropathy.

[070] Particularly preferred "T2D-related complications" include, but are not limited to, myocardial infarction, stroke, albuminuria and /or declining glomerular filtration

[071] An antibody specific for a polypeptide encoded by a gene identified in table 3, 6, 9 or 12 or containing a SNP listed in table 1, 4, 7, 10, 16 or 19 of the invention can be used to detect the polypeptide in a biological sample in order to evaluate the abundance and pattern of expression of the polypeptide. Antibodies can be used diagnostically to monitor protein levels in tissue such as blood as part of a test predicting the susceptibility to complications, such as, for example, myocardial infarction, stroke and/or albuminuria and /or declining glomerular filtration or as part of a clinical testing procedure, e.g., to, for example, determine the efficacy of a given treatment regimen. Highly purified antibodies (e.g. monoclonal humanized antibodies specific to a polypeptide encoded by an associated gene of the invention and/or polymorphic gene may be produced using GMP-compliant manufacturing processes known in the art. These "pharmaceutical grade" antibodies can be used in novel therapies modulating activity and/or function of a polypeptide encoded the associated gene(s) disclosed herein.

[072] This invention provides information on genomic markers that can be used to develop methods, reagents and kits useful to predict diabetes complications. Development of such methods, reagents and kits relies on methods known to those skilled in the art, including without limitation allele specific PCR amplification or detection of such alleles, with or without prior amplification, with allele specific probes, and DNA sequencing. Information on genomic DNA sequences from which PCR primers, hybridization probes, and sequencing primers can designed can be found in public databases using the rs ID provided for each SNP in Table 1, 4, 7, 10, 13, 14, 16 and 19.

[073] Diagnostic Methods and Test Kits

[074] One major application of the current invention is diagnosing a susceptibility to T2D related complications. The risk assessment methods and test kits of this invention can be applied to any diabetic patient as a screening or predisposition test, although the methods and test kits are also be applied to prediabetic patients and other subjects, preferably those with high-risk individuals (who have e.g. family history of T2D, history of gestational diabetes, previous glucose

intolerance, obesity or any combination of these). Diagnostic tests that define genetic factors contributing to T2D complications might be used together with or independent of the known clinical risk factors to define an individual's risk relative to the general population. Better means for identifying those individuals susceptible for a T2D-related complication should lead to better preventive and treatment regimens, including more aggressive management of the risk factors for a T2D-related complication such as obesity, lack of physical activity, hypercholesterolemia, elevated LDL cholesterol, low HDL cholesterol, elevated BP, cigarette smoking and inflammatory components as reflected by increased C-reactive protein levels or other inflammatory markers. Physicians may use the information on genetic risk factors to convince particular patients to adjust their life style e.g. to stop smoking, to reduce caloric intake or to increase exercise.

[075] In one embodiment of the invention, diagnosis of a susceptibility to T2D related complication in a subject is made by detecting one or more SNP markers disclosed in table 1, 4, 7, 10, 16 and 19 of this invention in the subject's nucleic acid. The presence of assessed SNP markers or haplotypes in individual's genome indicates subject's increased risk for said T2D related complication. The invention also pertains to methods of diagnosing a susceptibility to said complication in an individual comprising detection of a haplotype in a genetic aspect that is more frequently present in an individual having a T2D complication (affected), compared to the frequency of its presence an individual not having a T2D complication (control), wherein the presence of the haplotype is indicative of a susceptibility to T2D-related complication. A haplotype may be associated with a reduced rather than increased risk of said complication, wherein the presence of the haplotype is indicative of a reduced risk of T2D -related complication.

[076] In other embodiment of the invention, diagnosis of susceptibility to T2D-related complication, is done by detecting in the subject's nucleic acid one or more polymorphic sites which are in linkage disequilibrium with one or more SNP markers disclosed in table 1, 4, 7, 10, 16 and 19 of this invention. For a therapeutic purpose, the most useful polymorphic sites are those altering the biological activity of a polypeptide encoded by a T2D related complication gene set forth in Table 3, 6, 9 or 12. Examples of such functional polymorphisms include, but are not limited to frame shifts; premature stop codons, amino acid changing polymorphisms and polymorphisms inducing abnormal mRNA splicing. Nucleotide changes resulting in a change in polypeptide sequence in many cases alter the physiological properties of a polypeptide by

resulting in altered activity, distribution and stability or otherwise affect on properties of a polypeptide. Other useful polymorphic sites are those affecting transcription of a gene set forth in Table 3, 6, 9 or 12 or comprising a SNP listed in table 1, 4, 7, 10, 16, or 19 or translation of its mRNA due to altered tissue specificity, due to altered transcription rate, due to altered response to physiological status, due to altered translation efficiency of the mRNA and due to altered stability of die mRNA. The presence of nucleotide sequence variants altering the polypeptide structure and/or expression in said associated genes in individual's nucleic acid is diagnostic for susceptibility to T2D-related complication but for a diagnostic purpose, the variant may also be included in uncharted areas of the genome.

[077] In diagnostic assays determination of the nucleotides present in one or more SNP markers of this invention, as well as polymorphic sites associated therewith can be done by any method or technique which can accurately determine nucleotides present in a polymorphic site. Numerous suitable methods have been described in the art. These methods include, but are not limited to, hybridization assays, ligation assays, primer extension assays, enzymatic cleavage assays, chemical cleavage assays and any combinations of these assays. The assays may or may not include PCR, solid phase step, a microarray, modified oligonucleotides, labeled probes or labeled nucleotides and the assay may be multiplex or singleplex. As it is obvious in the art the nucleotides present in a polymorphic site can be determined from either nucleic acid strand or from both strands.

[078] In another embodiment of the invention, a susceptibility to a T2D-related complication is assessed from transcription products of one or more associated genes. Qualitative or quantitative alterations in transcription products can be assessed by a variety of methods described in die art, including e.g. hybridization methods, enzymatic cleavage assays, RT-PCR assays and microarrays. A test sample from an individual is collected and the alterations in the transcription of associated genes are assessed from the RNA molecules present in the sample. Altered transcription is diagnostic for a susceptibility to a T2D-related complication.

[079] In another embodiment of the invention, diagnosis of a susceptibility to T2D-related complication is made by examining expression, abundance, biological activities, structures and/or functions of polypeptides encoded by one of the gene disclosed in Table 3, 6, 9 or 12. A test sample from an individual is assessed for the presence of alterations in the expression, biological activities, structures and/or functions of the polypeptides, or for the presence of a

particular polypeptide variant (e.g., an isoform) encoded by a gene disclosed in Table 3, 6, 9 or 12. An alteration can be, for example, quantitative (an alteration in the quantity of the expressed polypeptide, i.e., the amount of polypeptide produced) or qualitative (an alteration in the structure and/or function of a polypeptide encoded by the polymorphic genes could be measured. Alterations in expression, abundance, biological activity, structure and/or function of polypeptides encoded by such polymorphic genes can be determined by various methods known in the art e.g. by assays based on chromatography, spectroscopy, colorimetry, electrophoresis, isoelectric focusing, specific cleavage, immunologic techniques and measurement of biological activity as well as combinations of different assays. An "alteration" in the polypeptide expression or composition, as used herein, refers to an alteration in expression or composition in a test sample, as compared with the expression or composition in a control sample and an alteration can be assessed either directly from the polypeptide itself or its fragment or from substrates and reaction products of said polypeptide. A control sample is a sample that corresponds to the test sample (e.g., is from the same type of cells), and is from an individual who is not affected by a T2D complication. An alteration in the expression, abundance, biological activity, function or composition of a polypeptide encoded by a polymorphic gene of the invention in the test sample, as compared with the control sample, is indicative of a susceptibility to developing complications. In another embodiment, assessment of the splicing variant or isoform(s) of a polypeptide encoded by a polymorphic gene can be performed directly (e.g., by examining the polypeptide itself), or indirectly (e.g., by examining the mRNA encoding the polypeptide, such as through mRNA profiling).

[080] Yet in another embodiment, a susceptibility to a T2D-related complication can be diagnosed by assessing the status and/or function of biological networks and/or metabolic pathways related to one or more polypeptides encoded by a T2D-related complication risk gene of this invention. Status and/or function of a biological network and/or a metabolic pathway can be assessed e.g. by measuring amount or composition of one or several polypeptides or metabolites belonging to the biological network and/or to the metabolic pathway from a biological sample taken from a subject. Risk to develop said complication is evaluated by comparing observed status and/or function of biological networks and or metabolic pathways of a subject to the status and/or function of biological networks and or metabolic pathways of healthy controls.

[081] Another major application of the current invention is diagnosis of a molecular subtype of

a type II diabetic patient. Molecular diagnosis methods and kits of this invention can be applied to a person having type II diabetes. In one preferred embodiment, molecular subtype of T2D in an individual is determined to provide information of the molecular etiology of T2D. When the molecular etiology is known, better diagnosis and prognosis of T2D can be made and efficient and safe therapy for treating T2D-related complications in an individual can be selected on the basis of this genetic subtype. For example, a drug that is likely to be effective, for example, a blood glucose lowering agent, can be selected without trial and error. Physicians may use the information on genetic risk factors with or without known clinical risk factors to convince particular patients to adjust their life style and manage T2D risk factors and select intensified preventive and curative interventions for them. In other embodiment, biomarker information obtained from methods and kits of the present invention are used to select human subjects for clinical trials testing anti-diabetic drugs. The kits provided for diagnosing a molecular subtype of T2D in an individual comprise wholly or in part protocol and reagents for detecting one or more biomarkers and interpretation software for data analysis and T2D molecular subtype assessment.

[082] The diagnostic assays and kits of die invention may further comprise a step of combining non-genetic information widi die biomarker data to make risk assessment, diagnosis or prognosis of a T2D-related complication. Useful non-genetic information comprises, without limitations, are age, gender, smoking status, physical activity, waist-to-hip circumference ratio (cm/cm), the subject family history of T2D or obesity, history of gestational diabetes, previously identified glucose intolerance, obesity, hypertriglyceridemia, low HDL cholesterol, HT and particularly elevated BP and/or status of being hypertensive. The detection mediod of die invention may also further comprise a step determining blood, serum or plasma glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, apolipoprotein B and AI, fibrinogen, ferritin, transferrin receptor, C-reactive protein, serum or plasma insulin concentration.

The score that predicts die probability of developing a T2D-related complication may be calculated using art-known procedures including but not limited to logistic regression, support vector machines and neural networks. The results from die furdier steps of die mediod as described below render possible a step of calculating die probability of developing such T2D- related complication using a logistic regression equation. Alternative statistical models include, but are not limited to, Cox's proportional hazards' model, otiber iterative models and neural networking models.

[083] Diagnostic test kits (e.g. reagent kits) of this invention comprise reagents, materials and protocols for assessing one or more biomarkers, and instructions and software for comparing the biomarker data from a subject to biomarker data from healthy and diseased people to make risk assessment, diagnosis or prognosis of a T2D related complication and optimized therapeutic suggestions. Useful reagents and materials for kits include, but are not limited to PCR primers, hybridization probes and primers as described herein (e.g., labeled probes or primers), allele-specific oligonucleotides, reagents for genotyping SNP markers, reagents for detection of labeled molecules, restriction enzymes (e.g., for RFLP analysis), DNA polymerases, RNA polymerases, DNA ligases, marker enzymes, antibodies which bind to altered or to non- altered (native) a polypeptide, means for amplification of nucleic acids fragments from one or more SNPs selected from the table 1, 4, 7, 10, 13, 14, 16 or 19, means for analyzing the nucleic acid sequence of one or more T2D-complication related SNPs, or means for analyzing the sequence of one or more amino acid residues of polypeptides encoded by genes comprising such SNPs, etc. In one embodiment, a kit for diagnosing susceptibility to a T2D-related complication comprises primers and reagents for detecting the nucleotides present in one or more SNP markers selected from the table 1, 4, 7, 10, 16 or 19 in individual's nucleic acid.

[084] Selection of patients for clinical trials

[085] Diabetes is very commonly associated with a significant risk of subsequent complications, such as cardiovascular diseases, stroke, macrovascular complications, and/or microvascular complications. Health Authorities, especially the US Food and Drug Administration (FDA), are concerned about recent reports of an increased rate of cardiovascular complications associated with the use of some anti-diabetic drugs. In order to protect the population, the FDA has requested very costly clinical studies to evaluate the cardiovascular risk of new diabetes drugs. For instance, in July 2008, the FDA convened a two-day meeting to discuss whether morbidity/mortality cardiovascular outcomes trials should be part of the approval process for pharmacological therapies developed for T2D. The resulting guidance was issued in December 2008 (Guidance for Industry: Diabetes Mellitus - Evaluating cardiovascular risk in new antidiabetic therapy to treat type 2 diabetes). In summary, the current standard for evaluation of efficacy have been strengthened by requiring further safety assessments, including long term ( minimum 2 years) cardiovascular evaluation, based either on meta-analysis or an ad hoc clinical trial with sufficient "hard" cardiovascular outcomes in the control arm. In this document the FDA insists on recruiting patients with higher risk of cardiovascular events. Further guidelines are soon expected soon for drugs that have already been approved. The new

requirements may, in turn, lead to the discontinuation of new drug development, and redirect available funding for diabetes research to other conditions.

[086] One way to improve outcome is to properly stratify patients for risk of adverse side effects. The current methods for selecting patient populations for such studies are based on well- established risk factors, such as previous cardiovascular events, unfavorable lipid or blood pressure profile, increased CRP, etc. These approaches are partially effective since clinical trials would require upwards of 50 000 subjects if unselected T2D patients were randomized. The use of clinical and biological biomarker-based characterization has reduced the pool size to about 15,000. Nonetheless, this still remains one of the most costly (more than US$150M) and time consuming steps in drug development. An example is a trial launched in November 2008 by Merck, Inc. on the cardiovascular safety of sitagliptin (JANUVIA) (NCT 00790205) in T2D subjects. This trial required 14,000 patients, even though pre-existing cardiovascular disease was utilized as a criterion for inclusion in this study.

[087] Correlations between genomic signatures as defined by SNPs and / or STRs combined with clinical/biological biomarkers, and cardiovascular complications in T2D patients provide a way to improve a researcher's ability to perform clinical outcome studies in a population. Using the methods and compositions in accordance with the embodiments of the instant invention herein disclosed, it is possible to reduce dramatically the number of subjects, and hence the cost of clinical studies, by selecting a filtered patient cohort comprising, for example, high-risk patients that are more likely to develop more cardiovascular complications than the general population of diabetes patients. Hence, in an embodiment of the instant invention, there is provided a means for identifying relevant genetic information and combining such information with other patient characteristics, such as, for example, age, sex, duration of diabetes, glycated hemoglobin, LDL and HDL cholesterol, hypertension, smoking, atrial fibrillation, ankle-arm blood pressure indices, pulse, symptomatic claudication and/or albuminuria, etc., which will be made available to companies developing new anti-diabetic drugs. Using the methods and compositions of the present invention, a researcher/clinician can identify a suitable patient cohort. Such may include, for example, patients likely to develop one or more of the aforementioned T2D related complications, etc.

[088] As such, in an embodiment of the present invention, there is provided a novel, genomic based classification tool for characterizing patients with higher risk for T2D complications. The

use of such a classification tool can dramatically reduce the sample size (and/or the time and cost) required to perform clinical safety outcome studies in T2D. Such outcome studies are typically utilized in the clinical trial setting, and can also be utilized in animal testing.

[089] As used herein, the term "clinical trial" means any research study designed to collect clinical data on responses to a particular treatment, and includes but is not limited to phase I, phase II and phase III clinical trials. Standard methods are used to define the patient population and to enroll subjects. Preferably, the clinical trials of the hereinbefore described embodiment of the instant invention relate to T2D and complications thereof, such as, for example, cardiovascular death, myocardial infarction, stroke, albuminuria and/or declining glomerular filtration, and the like.

[090] As illustrated in the Examples, a randomized clinical trial with two arms was designed to test the impact of novel antidiabetic medication on the rate of cardiovascular events in T2D patients. In one arm, patients receive the usual medication (control arm) whereas, in the other arm (treatment arm), patients receive the novel antidiabetic medication in addition to the usual medication. The number of samples used in both arms is such that a difference of 20% between the two arms' respective annual event rates will be detected with 80% power at a fixed significance level of 5%. A representative trial is planned for 5 years.

[091] Using the methods and the compositions of an embodiment of the instant invention, it is now possible to distinguish, without any overlap, Caucasians from Africans and Asians among T2D diabetic subjects. Using subsets of SNPs in number varying from almost 150 000 to 2 000, the present inventors have determined two predominant populations among Caucasians recruited in ADVANCE along the west/ east cline in Europe, with a majority of the Western type in Australia and Canada. An excess of complications that is observed in predominantly Eastern regions is mainly related with the frequency of some risk alleles compared to Western regions. Less frequently, the increased disease prevalence was found to be at least partially dependent on the allele penetrance, i.e., the population frequency is the same but the impact on the individual is more severe given its his/her genomic/environmental background. A first set of results has been obtained after genotyping (using Affymetrix Genome-Wide Human SNP Arrays 5.0 and 6.0) samples and analyzing data from nearly 2,000 T2D patients of Caucasian origin from 15 different countries. A case-control design was favored because it provides sufficient power to detect significant associations between phenotypes and alleles. Discriminative accuracy of best

associated SNPs was determined by the area under a "Receiver Operating Characteristics" (ROC) curve (AUC), which is widely used to quantify the predictive performance of different classifiers: a value of 0.5 refers to a random classification whereas a value of 1.0 refers to a perfect classification.

[092] An embodiment of the present invention also provides the use of training sets to fit models, highlighting variables which could possibly predict the outcome of interest. Under certain aspects, the testing set can used to assess the classification accuracy of the model on new known events. Two different models of classification were used: logistic regression and support vector machines. Logistic regression is a well known method which models the probability of a binary variable representing the outcome of interest (event vs. non-event) as a function of quantitative and/or categorical predictors. Support vector machine searches for optimal hyperplanes that separate two classes (here cases and controls) by maximizing the distance between the classes' closest points. The two methods gave similar predictive performance. As described in the Examples section, initial results on T2D complications show that the AUC increases to over 0.9 as the number of the best associated SNPs increases to 1000. Adding SNPs not associated to complications did not increase the predictive accuracy of the 3 methods. From the best associated SNPs in the entire dataset 95 independent SNPs maintaining 0.85 predictive value were identified. Using ADVANCE data, it was demonstrated for the first time that significant genomic determinants exists for vascular complications in diabetes. Furthermore, the micro-heterogeneity within the Caucasian population points to distinct conclusions on the impact of specific risk alleles, with, on one side, a significant potential for development of personalised medicine and, on the other side, the relevance for public health.

[093] Illustrative results include the following ones:

[094] Identification of over 1000 SNPs highly significantly associated (p < 10 ⁵ ) with T2D complications (kidney damage, myocardial infarction and stroke).

[095] Identification of risk and protective alleles

[096] Identification of genes and pathways associated with a specific or combined T2D complications

[097] Identification of a set of SNPs pertinent to geo-ethnic sub-groups among Caucasians to be used for stratification correction

[098] Determination that each most associated SNP alone has a low predictive value, while the combination of the 95 best SNPs reaches a predictive value of 0.85 for T2D complications.

[099] In an embodiment of the present invention, there is provided a method for correlating a genetic feature with an increased or reduced risk of developing a complication associated with type-2 diabetes (T2D) and utilization of such information in the recruitment of subjects in clinical trials. Such complications include, but are not limited to, myocardial infarction, stroke, albuminuria and/or declining glomerular filtration or a combination thereof.

[0100] Preferably, under this embodiment, the complication is stroke , albuminuria and/or declining glomerular filtration.

[0101] The genetic feature is preferably a SNP or a STR, or a combination thereof.

[0102] Under this embodiment, it is particularly preferable to detect a genetic feature which is

(a) at least one single nucleotide polymorphism (SNP) listed in Table 1, 4, 7, 10, 16 or 19;

(b) at least one SNP which is in linkage disequlibrium with at least one SNP of (a); or

(c) at least one short tandem repeat (STR) that is in linkage disequilibrium with at least one SNP of (a).

[0103] According to an embodiment of the present invention, there is thus provided a method for characterizing a subject for inclusion or exclusion from a clinical trial, comprising detecting, in a sample obtained from said subject, the presence or absence of at least one genetic feature which is

(a) at least one single nucleotide polymorphism (SNP) listed in Table 1, 4, 7, 10, 16 or 19;

(b) at least one SNP which is in linkage disequlibrium with at least one SNP of (a); or

(c) at least one short tandem repeat (STR) that is in linkage disequilibrium with at least one SNP of (a).

[0104] Preferably, the methods of the hereinbefore described embodiment of the instant invention involve detection of one or more of the aforementioned genetic features using techniques that are known in the art, such as those disclosed in the Examples. The present invention can also be practiced by using a wide variety of techniques and reagents which are known in the art for detecting the absence of the aforementioned genetic features, for example, using probe sequences that detect wild-type nucleic acid sequences.

[0105] In a related embodiment, there is provided a method for characterizing a subject for inclusion or exclusion from a clinical trial, comprising detecting, in a sample obtained from said subject, the presence or absence of at least one genetic feature which is an SNP or a STR of at least one gene which is listed in Table 3, 6, 9.

[0106] As described in the Brief Description of the Tables section of this application, the genes of Table 3 relate to the SNPs of Table 1 via whole genome association. Herein, one or more of the SNPs listed in Table 1 are located either inside the gene (exon, intron, 5 ¹ UTR, 3'UTR) or very close to the gene of Table 3 (as defined by NCBI). Similarly, the genes of Table 6 relate to the myocardial infarction SNPs of Table 4. The relation between the SNPs and the genes is similar to that of Table 1 and Table 3. Lastly, the genes of Table 9 and 12 relate to the kidney- complication associated SNPs of Table 7 and 10, respectively. Herein, one or more of the SNPs listed in Table 7 or 10 are located either inside the gene (exon, intron, 5'UTR, 3'UTR) or very close to the gene of Table 9 or 12, respectively (as defined by NCBI).

[0107] In a more preferred embodiment, there is provided a method for selecting a patient for clinical trials comprising detecting in a biological sample of said patient, the presence or absence of at least one SNP listed in Table 1, 4, 7, 10, 16 or 19, said SNP being selected on the basis of its p value of association with a complication, allele frequency, or odds ratio.

[0108] Under a related embodiment of the present invention, there is provided a method for characterizing patients for clinical trials based on the detection of a combination of biomarkers.

[0109] In such methods, better characterization of the patient cohort can be achieved. Any combinations of SNP listed in tables 1, 4, 7, 10, 16 and 19 may be detected. Such combinations can be developed on the basis of, for example, level of association with a complication of interest and on the frequency of other genetic features. Such other genetic features, for example, risk or protective alleles in the population, etc. may be included. Several methods are known by those skilled in the art to select appropriate markers.

[0110] Under such embodiments of the instant invention wherein a combination of SNPs is detected, it is particularly preferable to employ a combination of biomarkers provided in tables 16 and 19.

[0111] Under such embodiments, any two, any four, any five, any ten, any twenty, or more of the SNPs listed in Tables 16 and/or 19 may be detected.

[0112] The compositions and methods of the present invention also provide methods for reducing the cost and time for anti-diabetic drug development by "enriching" the outcome trial pool with pre-selected patients that are at greater risk of T2D-related complications. To this end, the present application describes methods for calculating a Risk Index Score, which combines clinical/biological biomarkers with genomic markers with high predictive performance. Such risk scores allow identification of a population subset with a higher complication rate. The Risk Index Score, can be optionally integrated into a Clinical Research Tool, thus facilitating evaluation of efficacy/safety balance in T2D by improving the signal to noise ratio.

[0113] In a related embodiment, the present application relates to kits and combinations that allow for practicing one or more of the aforementioned methods.

[0114] Under this embodiment, there is provided combinations and kits for identifying a subject for clinical trial, wherein said subject is affected by type-2 diabetes (T2D) comprising in one or more packages

(a) an oligonucleotide that specifically hybridizes to a SNP having the RefSNP ID listed in Table 1, 4, 7, 10, 16 or 19; or

(b) an oligonucleotide which is the complement of (a); and one or more reagents for the detection of said oligonucleotide.

[0115] Methods of Therapy

[0116] The present invention discloses novel methods for the prevention and treatment of a T2D-related complication. In particular, the invention relates to methods of treatment of T2D- related complications. The term, "treatment" as used herein, refers not only to ameliorating symptoms associated with the disease, but also preventing or delaying the onset of the complication, and also lessening the severity or frequency of symptoms of the disease, preventing or delaying the occurrence of a second episode of the disease or condition; and/or also lessening the severity or frequency of symptoms of the disease or condition.

[0117] The present invention encompasses methods of treatment (prophylactic and/or therapeutic) for a T2D-related complication using a therapeutic agent. A "therapeutic agent" is

an agent that alters (e.g., enhances or inhibits) enzymatic activity or function of a risk gene such as those disclosed in Table 3, 6, 9 and 12 and/or expression of polymorphisms disclosed in table 1, 4, 7, 10, 16 and 19 and /or the specific metabolic or other biologically related pathway implicating those genes. The modes of useful therapeutic agents are further disclosed.

[0118] Representative therapeutic agents of the invention comprise the following: (a) nucleic acids, fragments, variants or derivatives of the genes, nucleic acids, or an active fragment or a derivative thereof and nucleic acids modifying the expression of said genes (e.g. antisense polynucleotides, catalytically active polynucleotides (e.g. ribozymes and DNAzymes), molecules inducing RNA interference (RNAi) and micro RNA), and vectors comprising said nucleic acids; (b) polypeptides, active fragments, variants or derivatives thereof, binding agents of polypeptides; peptidomimetics; fusion proteins or prodrugs thereof, antibodies; (c) metabolites of the gene products; (d) small molecules and compounds that alter (e.g., inhibit or antagonize) a risk gene expression, activity and/or function of a polypeptide encoded by said genes and; (e) small molecules and compounds diat alter (e.g. induce, agonize or modulate) the expression or activity of said genes.

[0119] The nucleic acid sequences of T2D-related complication associated risk genes such as those disclosed in Table 3, 6, 9 and 12 and/or polymorphisms disclosed in table 1, 4, 7, 10, 16 and 19 of this application are publicly available and can be used to design and develop therapeutic nucleic acid molecules and recombinant DNA molecules for the prevention and treatment of T2D or a T2D related condition. For example antisense nucleic acid molecules targeted to a polymorphism in tables 1, 4, 7, 10, 16 and 19 can be designed using tools and the nucleotide sequence of the gene available in the art and constructed using chemical synthesis and/or enzymatic ligation reactions using procedures known in the art. Antisense nucleic acid molecule can be chemically synthesized using naturally occurring nucleotides or modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense oligonucleotide and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used.

[0120] Alternatively, the antisense nucleic acid molecule can be produced biologically using an expression vector into which a nucleic acid molecule encoding a T2D- related complication risk gene, a fragment or a variant thereof has been cloned in antisense orientation (i.e., RNA transcribed from the expression vector will be complementary to the transcribed RNA of a T2D-

related complication risk gene of interest).

[0121] More than one T2D-related complication therapeutic agent can be used concurrently, if desired. The therapy is designed to affect 1) expression of a T2D-related complication gene in a sense of activation, inhibition or modulation, 2) abundance, stability, biological activity and/or function of a T2D-related complication risk gene-encoded ribonucleic acid or polypeptide, or 3) biological activity and/or function of a T2D-related complication gene related signaling or metabolic pathway. Upregulation or increasing expression of a T2D-related complication risk gene or a particular variant of a T2D-related complication 4, 7, 10, 16 and 19 susceptibility gene could interfere with or compensate for the expression or activity of a defective gene or variant; downregulation or decreasing expression or availability of a native risk gene or a particular splicing variant of a T2D-related complication susceptibility gene could minimize the expression or activity of a defective gene or the particular variant and thereby minimize the impact of the defective gene or the particular variant.

[0122] The T2D and T2D-related complication therapeutic agent(s) are administered in a therapeutically effective amount that can be determined using established clinical methods and assays. The precise dose to be employed in the formulation will also depend on the route of administration, and the seriousness of the disease or disorder, and should be decided according to the judgment of a practitioner. Effective doses may be extrapolated from dose-response curves derived from in vitro or animal model test systems.

[0123] In one embodiment, a nucleic acid encoding a T2D— related complication polypeptide, fragment, variant or derivative thereof, either by itself or included within a vector, can be introduced into cells of an individual affected by T2D or a T2D related condition using variety of experimental methods described in the art, so that the treated cells start to produce native T2D-related complication susceptibility polypeptide. Thus, cells which, in nature, lack of a native T2D-related complication risk gene expression and activity, or have abnormal T2D-related complication risk gene expression and activity, can be engineered to express a T2D-related complication polypeptide or an active fragment or a different variant of said T2D-related complication susceptibility polypeptide. Genetic engineering of cells may be done either "ex vivo" (i.e. suitable cells are isolated and purified from a patient and re-infused back to the patient after genetic engineering) or "in vivo" (i.e. genetic engineering is done directly to a tissue of a patient using a vehicle). Alternatively, in another embodiment of the invention, a nucleic acid

(e.g. a polynucleotide) which specifically hybridizes to the mRNA and/or genomic DNA of a T2D-related complication gene is administered in a pharmaceutical composition to the target cells or said nucleic acid is generated "in vivo". The antisense nucleic acid that specifically hybridizes to the mRNA and/or DNA inhibits expression of the T2D-related complication polypeptide, e.g., by inhibiting translation and/or transcription. Binding of the antisense nucleic acid can be due to conventional base pairing _s or, for example, in the case of binding to DNA duplexes, through specific interaction in the major groove of the double helix. In a preferred embodiment nucleic acid therapeutic agents of the invention are delivered into cells that express one or more T2D-related complication risk genes. A number of methods including, but not limited to, the methods known in the art can be used for delivering a nucleic acid to said cells. For example, a vector can be introduced in vivo such that it is taken up by a cell and directs the transcription of a RNA molecule, which induces RNA interference in the cell. Such a vector can remain episomal or become chromosomally integrated, and as long as it can be transcribed to produce the desired RNA molecules it will modify the expression of a T2D-related complication risk gene. Such vectors can be constructed by various recombinant DNA technology methods standard in the art.

[0124] The expression of an endogenous T2D-related complication risk gene can be reduced by inactivating completely ("knocking out") or partially ("knocking down") a T2D-related complication gene using targeted homologous recombination methods described in the art. Alternatively, expression of a functional, non-mutant T2D-related complication can be increased using a similar method: targeted homologous recombination can be used to replace a nonfunctional T2D-related complication risk gene with a functional form of the said gene in a cell. In another embodiment of the invention, other T2D therapeutic agents as described herein can also be used in the treatment or prevention of T2D or a related condition. The therapeutic agents can be delivered in a pharmaceutical composition; they can be administered systemically, or can be targeted to a particular tissue. The therapeutic agents can be produced by a variety of means, including chemical synthesis, cell culture and recombinant techniques (e.g. with transgenic cells and animals). Therapeutic agents can be isolated and purified to fulfill pharmaceutical requirements using standard methods described in the art. A combination of any of the above methods of treatment (e.g., administration of non-mutant T2D-related complication susceptibility polypeptide in conjunction with RNA molecules inducing RNA interference targeted to the mutant T2D-related complication susceptibility mRNA) can also be used.

[0125] In the case of pharmaceutical therapy the invention comprises compounds which affect 1) expression of a T2D-related complication gene in a sense of activation, inhibition or modulation, 2) abundance, stability, biological activity and/or function of a T2D-related complication risk gene-encoded ribonucleic acid or polypeptide, or 3) biological activity and/or function of a T2D-related complication gene or metabolic pathway encoded by T2D complication-associated risk genes such as those disclosed in Table 3, 6, 9 and 12 and/or polymorphisms disclosed in table 1, 4, 7, 10, 16 and 19 of this application. The treatment may also exert its effects as specified above on one or several genes selected from the T2D complication-associated risk genes such as those disclosed in Table 3, 6, 9 and 12 and/or polymorphisms disclosed in table 1, 4, 7, 10, 16 and 19 of this application.

[0126] Furthermore, a disclosed method or a test based on biomarkers specific for T2D-related complication susceptibility gene is useful in selection, modification or optimalization of therapeutic modalities for T2D-patients. For example if the less frequent, i.e. the minor, assumable mutated allele in the T2D-related complication susceptibility gene is risk-reducing, and if said mutation is a gene function reducing mutation, one can deduce that the gene function and/or activity would increase the risk of T2D complication. On that basis, drugs and other therapies such as gene therapies that reduce or inhibit the function or activity of the T2D-related complication susceptibility gene or the encoded protein would reduce the risk of the said T2D- related complication and could be used to both prevent and treat the said T2D-related complication in subjects having said mutated allele.

[0127] In another embodiment of the invention a T2D or T2D-related complication therapeutic agent comprises a known therapeutic agent related to a T2D-related complication associated gene listed in tables 3, 6, 9 or 12 of this invention but which is not used to treat T2D or a T2D- related complication. Such compounds and therapeutic agents are useful for developing new therapies for T2D or a T2D-related complication as they most likely affect 1) expression of a T2D-related complication gene in a sense of activation, inhibition or modulation, 2) abundance, stability, biological activity and/or function of a T2D-related complication risk gene-encoded ribonucleic acid or polypeptide, or 3) biological activity and/or function of a T2D-related complication gene related signaling or metabolic pathway. These agents may be used alone or in combination with other treatments and agents used for prevention or treatment of T2D or a T2D-related condition.

[0128] In one embodiment of the invention, therapeutic agents or compounds currently utilized for the treatment of T2D and T2D-related complications are combined with one or more known dierapeutic agents used to treat T2D comprising I. oral antidiabetics including biguanid derivatives such as 1) metformin, 2) buformin, insulin secretogogues such as 1) sulphonylurea derivatives such as tolbutamide, glibenclamide, gliclazide, glipizide,, glimepiride, gliquidone; 2) meglitinides such as repaglinide, nateglinide; 3) alpha-glucosidase inhibitors such as acarbose, miglitol; 4) thiazolidinediones such as rosiglitazone and pioglitazone; 5) other defined by World Health Organisation - The Anatomical Therapeutic Chemical (ATC) classification system; II. insulin such as i)insulin glargine, ii) insulin aspart, in) insulin lispro, iv) insulin glulisine; v) insulin detemir; and agents known do decrease and or prevent diabetes related complication, such as high blood pressure, i) converting enzyme inhibitors, ϋ) angiotensin receptor blockers, iϋ) direct renin inhibitors, iv) endothelin antagonists, v)diuretics, vi)beta blockers, vϋ)alpha blockers, viii) inhibitors of phospodiesterase 5a and the combinations thereof.

[0129] Pharmaceutical Compositions

[0130] The present invention also pertains to pharmaceutical compositions comprising agents described herein, particularly polynucleotides, polypeptides and any fractions, variants or derivatives of T2D-related complication genes, and/or agents that alter (e.g., enhance or inhibit) expression of a risk gene or genes, or activity of one or more polypeptides encoded by associated genes as described herein. For instance, an agent that alters expression of a risk gene or activity of one or more polypeptides encoded thereby.

[0131] Agents described herein can be formulated as neutral or salt forms. Pharmaceutically acceptable salts include those formed with free amino groups such as those derived from hydrochloric, phosphoric, acetic, oxalic, tartaric acids, etc., and those formed with free carboxyl groups such as those derived from sodium, potassium, ammonium, calcium, ferric hydroxides, isopropylamine, triethylamine, 2-ediylamino ethanol, histidine, procaine, etc. Suitable pharmaceutically acceptable carriers include but are not limited to water, salt solutions (e.g., NaCl), saline, buffered saline, alcohols, glycerol, edianol, gum arabic, vegetable oils, benzyl alcohols, polyethylene glycols, gelatin, carbohydrates such as lactose, amylose or starch, dextrose, magnesium stearate, talc, silicic acid, viscous paraffin, perfume oil, fatty acid esters, hydroxymethylcellulose, polyvinyl pyrolidone, etc., as well as combinations thereof. The pharmaceutical preparations can, if desired, be mixed with auxiliary agents, e.g., lubricants, preservatives, stabilizers, wetting agents, emulsifiers, salts for influencing osmotic pressure,

buffers, coloring, flavoring and/or aromatic substances and the like which do not deleteriously react with the active agents.

[0132] The composition, if desired, can also contain minor amounts of wetting or emulsifying agents, or pH buffering agents. The composition can be a liquid solution, suspension, emulsion, tablet, pill, capsule, sustained release formulation, or powder. The composition can be formulated as a suppository, with traditional binders and carriers such as triglycerides. Oral formulation can include standard carriers such as pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, polyvinyl pyrolidone, sodium saccharine, cellulose, magnesium carbonate, etc.

[0133] Methods of introduction of these compositions include, but are not limited to, intradermal, intramuscular, intraperitoneal, intraocular, intravenous, subcutaneous, topical, oral and intranasal. Odier suitable methods of introduction can also include gene therapy (as described below), rechargeable or biodegradable devices, particle acceleration devises ("gene guns") and slow release polymeric devices. The pharmaceutical compositions of this invention can also be administered as part of a combinatorial therapy with other agents. The composition can be formulated in accordance with the routine procedures as a pharmaceutical composition adapted for administration to human beings. For example, compositions for intravenous administration typically are solutions in sterile isotonic aqueous buffer. Where necessary, the composition may also include a solubilizing agent and a local anesthetic to ease pain at the site of the injection. Generally, the ingredients are supplied either separately or mixed together in unit dosage form, for example, as a dry lyophilized powder or water free concentrate in a hermetically sealed container such as an ampule or sachette indicating the quantity of active agent. Where the composition is to be administered by infusion, it can be dispensed with an infusion bottle containing sterile pharmaceutical grade water, saline or dextrose/water. Where the composition is administered by injection, an ampule of sterile water for injection or saline can be provided so that the ingredients may be mixed prior to administration. For topical application, nonsprayable forms, viscous to semi-solid or solid forms comprising a carrier compatible with topical application and having a dynamic viscosity preferably greater than water, can be employed. Suitable formulations include but are not limited to solutions, suspensions, emulsions, creams, ointments, powders, enemas, lotions, sols, liniments, salves, aerosols, etc., which are, if desired, sterilized or mixed with auxiliary agents, e.g., preservatives, stabilizers, wetting agents, buffers or salts for influencing osmotic pressure, etc. The agent may be incorporated into a cosmetic

formulation. For topical application, also suitable are sprayable aerosol preparations wherein the active ingredient, preferably in combination with a solid or liquid inert carrier material, is packaged in a squeeze bottle or in admixture with a pressurized volatile, normally gaseous propellant, e.g., pressurized air.

[0134] The agents are administered in a therapeutically effective amount. The amount of agents which will be therapeutically effective in the treatment of a particular disorder or condition will depend on the nature of the disorder or condition, and can be determined by standard clinical techniques. In addition, in vitro or in vivo assays may optionally be employed to help identify optimal dosage ranges. The precise dose to be employed in the formulation will also depend on the route of administration, and the seriousness of the symptoms of a T2D-related complication, and should be decided according to the judgment of a practitioner and each patient's circumstances. Effective doses may be extrapolated from dose-response curves derived from in vitro or animal model test systems.

[0135] Functional Foods

[0136] By definition "functional foods" or "nutraceuticals" are foods or dietary components or food ingredients that may provide a health benefit beyond basic nutrition. Functional foods are regulated by authorities (e.g. by the FDA in US) according to their intended use and the nature of claims made on the package. Functional foods can be produced by various methods and processes known in the art including, but not limited to synthesis (chemical or microbial), extraction from a biological material, mixing functional ingredient or component to a regular food product, fermentation or using a biotechnological process. A functional food may exert its effects directly in the human body or it may function e.g. through human intestinal bacterial flora.

[0137] The associated genes disclosed in Table 3, 6, 9 and 12 of this invention can be used as molecular targets towards which functional foods claiming health benefit in a T2D related complication can be developed. For example a functional food may compensate reduced biological activity of a polypeptide encoded by a gene set forth in Table 3, 6, 9 or 12 when the risk gene is defective or is not expressed properly in a subject. A functional food may also inhibit the expression and/or biological activity of a gene or polypeptide of the invention promoting the development of a T2D related complication. In another embodiment a functional food may increase the expression and/or biological activity of a gene or polypeptide protecting an

individual from the development of a T2D related complication due to reduced expression and protein production.

[0138] Aspects of the instant invention include, but are not limited to:

Aspect 1. A method for predicting a risk of developing a complication which is myocardial infarction, stroke, or albuminuria and /or declining glomerular filtratrion in a subject affected by T2D, comprising detecting, in a sample obtained from said subject, at least one genetic feature which is single nucleotide polymorphism (SNP), short tandem repeat (STR), wherein the detection of said genetic feature in said subject correlates with said risk of developing at least one of said complication.

Aspect 2. The method according to aspect 1, wherein said SNP comprises a polymorphism of a gene or a locus Linked thereto.

Aspect 3. The method according to aspect 1, wherein said genetic feature comprises at least one feature listed in Table 1, 4, 7, 10, 16 or 19.

Aspect 4. The method according to aspect 1, wherein said genetic feature is at least one

SNP listed in Table 1, 4, 7, 10, 16 or 19.

Aspect 5. The method according to aspect 1, wherein said genetic feature is at least one

SNP or one STR found to be in linkage disequilibrium with a SNP listed in Table 1, 4, 7, 10, 16 or 19.

Aspect 6. The method according to aspect 1, comprising detecting a SNP or a STR of at least one gene which is listed in Table 3, 6, 9 or 12.

Aspect 7. The method according to aspect 1, wherein detection of said genetic feature correlates with increased or reduced risk of developing said complication.

Aspect 8. A method for predicting a risk of developing a complication which is myocardial infarction, stroke, or albuminuria and /or declining glomerular filtration in a subject affected by type II diabetes, comprising detecting, in a sample obtained from said subject, at least one single

nucleotide polymorphism (SNP) from the SNPs listed in Table 1, 4, 7, 10, 16 or 19, or at least one SNP or one TR found to be in linkage disequilibrium with at least one SNP listed in Table 1, 4, 7, 10, 16 or 19, wherein the detection of said SNP or STR in said subject correlates with said risk of developing said complication.

Aspect 9. A method for predicting a risk of developing a complication which is myocardial infarction, stroke, or albuminuria and /or declining glomerular filtration in a subject affected by T2D, comprising detecting, in a sample obtained from said subject, at least one (SNP) from at least on gene listed in Table 3, 6, 9 or 12 or at least one STR found to be in linkage disequilibrium with at least one (SNP) from at least one gene listed in Table 3, 6, 9 or 12, wherein the detection of said SNP or STR in said subject correlates with said risk of developing said complication.

Aspect 10: A method for predicting the risk of developing a complication which is myocardial infarction, stroke, albuminuria and /or declining glomerular filtration or any combination thereof in a subject having type II diabetes, comprising detecting at least one SNP from the list of SNPs of Table 1, 4, 7, 10, 16 or 19, said SNP being selected on the basis of its p value of association with said complication(s), allele frequency and odds ratio.

Aspect 11. The method according to aspects 8 or 9 or 10, comprising detecting at least two SNPs.

Aspect 12. The method according to aspects 8 or 9 or 10, comprising detecting at least three SNPs.

Aspect 13. The method according to aspects 8 or 9 or 10, comprising detecting more than three SNPs

Aspect 14. The method according to aspects 8 or 9 or 10, wherein said STR and/or SNP is detected in said patient in a specific geo-ethnic context.

Aspect 15: The method of aspect 14, wherein the geoethnic origin of an individual is determined using SNPs selected from the SNPs listed in Table 13 or 14.

Aspect 16. The method according to aspect 1, wherein the genetic feature is

(a) at least one single nucleotide polymorphism (SNP) listed in Table 16 or 19;

(b) at least one SNP which is in linkage disequilibrium with at least one SNP of (a); or

(c) short tandem repeat (STR) that is in linkage disequilibrium with at least one SNP of (a).

Aspect 17. The method according to Aspect 16, comprising detecting at least two SNPs from the SNPs listed in Table 16 or 19.

Aspect 18. The method according to Aspect 16, comprising detecting at least diree SNPs from the SNPs listed in Table 16 or 19.

Aspect 19. The method according to aspect 1, widi the proviso that said at least one SNP is not one of the SNPs listed in Table 20.

Aspect 20. The method according to aspect 2, with the proviso that said at least one gene is not one of the genes listed in Table 21.

Aspect 21. A kit for predicting a complication which is myocardial infarction, stroke or albuminuria in a subject affected by type-2 diabetes (T2D) comprising in one or more packages

(a) an oligonucleotide that specifically hybridizes to a SNP having the RefSNP ID listed in Table 1, 4, 7, 10, 16 or 19; or

(b) an oligonucleotide which is the complement of (a); and one or more reagents for the detection of said oligonucleotide.

Aspect 22. The kit according to aspect 21, comprising one or more reagents for polymerase chain reaction (PCR).

Aspect 23. The kit of aspect 21, further comprising an RNase.

Aspect 24. The kit of aspect 21, which further comprises one or more reagents for isolation of cells from a sample.

Aspect 25. The kit of aspect 24, wherein said sample is a blood sample.

Aspect 26. The kit of aspect 21, further comprising a DNAse inhibitor.

Aspect 27. The kit of aspect 21, further comprising reagents for sequencing in one or more packages.

Aspect 28. The kit of aspect 21, further comprising a cDNA microarray plate in one or more packages.

Aspect 29. The kit of aspect 21, wherein the oligonucleotide comprises the probe sequences of Tables 2, 5, 8, 9, 11 and 16.

Aspect 30. The kit of aspect 21, wherein the oligonucleotide is

(a) an oligonucleotide comprising at least 80% sequence identity to the oligonucleotide having the RefSNP ID listed in Table 1, 4, 7, 10, 16 or 19; or

(b) an oligonucleotide which is complimentary to the oligonucleotide of (a).

Aspect 31. The kit of aspect 30, wherein the oligonucleotide is

(c) an oligonucleotide comprising at least 90% sequence identity to the oligonucleotide having the RefSNP ID listed in Table 1, 4, 7, 10, 16 or 19; or

(d) an oligonucleotide which is complimentary to the oligonucleotide of (a).

Aspect 32. The kit of aspect 30, wherein the oligonucleotide is

(e) an oligonucleotide comprising at least 95% sequence identity to the oligonucleotide having the RefSNP ID listed in Table 1, 4, 7, 10, 16 or 19; or

(f) an oligonucleotide which is complimentary to the oligonucleotide of (a).

Aspect 33. The kit of aspect 30, wherein the oligonucleotide is

(g) an oligonucleotide comprising at least 100% sequence identity to the oligonucleotide having the RefSNP ID listed in Table 1, 4, 7, 10, 16 or 19; or

(h) an oligonucleotide which is complimentary to the oligonucleotide of (a).

Aspect 34. The kit of aspect 21, which further comprises a control oligonucleotide that hybridizes to the wild-type allele.

Aspect 35. Use of a kit according to Aspect 21 for predicting a complication which is

myocardial infarction, stroke, albuminuria or declining glomerular filtration in a subject affected by type-2 diabetes (T2D).

Aspect 36. A method for preventing, treating or reducing the risk of T2D or a T2D related complication which is myocardial infarction, stroke, albuminuria or declining glomerular filtration in a subject in need thereof, comprising administrating to said subject a therapeutic agent which

(a) alters the enzymatic activity or levels of a polypeptide encoded by at least one risk gene listed in Table 3, 6, 9; or

(b) alters the expression of at least one polymorphism disclosed in table 1, 4, 7, 10, 16, or 19; or

(c) alters the specific metabolic or other biologically related pathway implicating the risk gene of (a).

Aspect 37. The method according to aspect 36, wherein the therapeutic agent alters the expression of at least one polymorphism disclosed in table 1, 4, 7, 10, 16, or 19.

Aspect 38. The method according to aspect 37, wherein the therapeutic agent is an antisense oligonucleotide or an siRNA.

Aspect 39. The method according to aspect 36, wherein the therapeutic agent alters the levels or enzymatic activity of a polypeptide encoded by at least one risk gene listed in Table 3, 6, 9.

Aspect 40. The method according to aspect 39, wherein the therapeutic agent is an antibody.

Aspect 41. A method for identifying a subject for preventive therapeutic action, comprising detecting, in a sample obtained from said subject, at least one genetic feature which is

(a) at least one single nucleotide polymorphism (SNP) listed in Table 1, 4, 7, 10, 16 or 19;

(b) at least one SNP which is in linkage disequilibrium with at least one SNP of (a); or

(c) short tandem repeat (STR) that is in linkage disequilibrium with at least one SNP of (a), wherein the detection of said genetic feature in said subject correlates with the eligibility of said subject for said preventive therapeutic action.

[0139] Additional aspects of the instant invention include, but are not limited to:

Aspect A. A method for characterizing a subject for inclusion or exclusion from a clinical trial, comprising detecting, in a sample obtained from said subject, the presence or absence of at least one genetic feature which is

(a) at least one single nucleotide polymorphism (SNP) listed in Table 1, 4, 7, 10, 16 or 19;

(b) at least one SNP which is in linkage disequilibrium with at least one SNP of (a); or

(c) at least one short tandem repeat (STR) that is in linkage disequilibrium with at least one SNP of (a).

Aspect B. The method according to Aspect A, comprising detecting a SNP or a STR of at least one gene which is listed in Table 3, 6, 9.

Aspect C. The method according to Aspect A, wherein detection of said genetic feature correlates with an increased or reduced risk of developing a complication associated with type 2 diabetes (T2D).

Aspect D. The method according to Aspect C, wherein detection of said genetic feature correlates with increased risk of developing said complication associated with T2D.

Aspect E. The method according to Aspect C, wherein said complication associated with T2D is myocardial infarction, stroke, albuminuria or declining glomerular filtration or a combination thereof.

Aspect F: The method according to Aspect E, comprising detecting at least one SNP from the list of SNPs of Table 1, 4, 7 or 10, said SNP being selected on the basis of its p value of association with said complication(s), allele frequency or odds ratio.

Aspect G. The method according to Aspect A, comprising detecting at least two SNPs.

Aspect H. The method according to Aspect A, comprising detecting at least three SNPs.

Aspect I. The method according to Aspect A, comprising detecting more than three SNPs.

Aspect J. The method according to Aspect A, wherein said STR and/or SNP is detected in said patient in a specific demographically-defined population.

Aspect K. The method according to Aspect A, wherein if said genetic feature is detected in said subject, then the subject is included in said clinical trial.

Aspect L. The method according to Aspect A, for characterizing a subject for inclusion in a clinical trial comprising detecting the presence of said at least one genetic feature.

Aspect M. The method according to Aspect A, for characterizing a subject for exclusion from a clinical trial comprising detecting the absence of said at least one genetic feature.

Aspect N. The method according to Aspect A, wherein the genetic feature is

(a) at least one single nucleotide polymorphism (SNP) listed in Table 16 or 19;

(b) at least one SNP which is in linkage disequlibrium with at least one SNP of (a); or

(c) short tandem repeat (STR) that is in linkage disequilibrium with at least one SNP of (a).

Aspect O. The method according to Aspect N, comprising detecting at least two SNPs from the SNPs listed in Table 16 or 19.

Aspect P. The method according to Aspect N, comprising detecting at least three SNPs from die SNPs listed in Table 16 or 19.

Aspect Q. The method according to aspect A, with the proviso diat said at least one SNP is not one of the SNPs listed in Table 20.

Aspect R. The method according to aspect B, with die proviso diat said at least one gene is not one of the genes listed in Table 21.

[0140] The entire disclosures of all applications, patents and publications, cited above and below, are hereby incorporated by reference.

BRIEF DESCRIPTION OF THE DRAWINGS AND TABLES

[0141] Various features and attendant advantages of the present invention will be more fully appreciated as the same becomes better understood when considered in conjunction with the accompanying drawings, in which like reference characters designate the same or similar parts throughout the several views, and wherein:

[0142] FIG. 1. Genetic axis of variations were constructed using two principal components based on 14961 SNPs characterized by minor allele frequency of more than 10%, with a call rate of 100%, and HWE p > 0.0001 equally distributed over the genome at every 100kb, unrelated to complications on all autosomes.

[0143] FIG. 2. Histogram of number of individuals by the three main regions defined by PCA analysis described in Figure 1 , for each country included in the dataset.

[0144] FIG. 3. Prevalence of T2D complications (albuminuria and /or declining glomerular filtratrion, stroke and MI) in each country included in the dataset.

[0145] FIG. 4 shows three-panel, Upper, prevalence of the complication, Middle, frequency of the risk allele and lower, odds ratio of risk for all individuals or individual belonging to regions 1, 2 or 3 respectively, for selected examples of SNPs and complications. The allelic odds ratio (OR) were computed for the same phenotype as the association was found. The five examples shown are for A: SNP rs4664386, albuminuria, B:. SNP rs 7557611, complication, C: SNP rsl516093, MI, D: SNP rs7126809, stroke and E, rs9457730, albuminuria. Panels A-C show that the frequency of the risk allele is higher in region 3 which also exhibits higher prevalence of the complications while panels D and E show same frequency of the risk allele for both regions but higher odds ratio of risk in region 1 or 3. The geo-ethnic specificity has to be taken into account for the development of predictive tools based on genomic signatures.

[0146] FIG 5: AUC scores of best associated SNPs (with imputation) and random SNPs with leave-one-out cross-validation vs. number of SNPs. In order to use all of our subjects, genotype imputation was performed with fastPHASE. The missing genotype rate par person doesn't exceed 10%.

[0147] FIG 6: AUC scores of 4 different datasets with leave-one-out cross-validation from 50 to 250 SNPs. Set 1: Imputed genotypes. Set 2: Imputed genotypes plus random SNPs 50* I _. N/2 J random SNPs, N= [1,20]. Set 3: Random SNPs. Set 4: 95 SNPs after feature selection

[0148] FIG 7: Results of bootstrap analysis using the four models described in Example 2 (Logistic regression).

[0149] FIG 8: Impact of the annual event rate in the control arm on the number of patients which need to be enrolled at entry of a clinical trial aimed at detecting differences between cardiovascular events in T2D patients treated or not with new medication.

[0150] Table 1: Results of whole genome association (WGA) tests for three different sample sets: all 1908 individuals and individuals belonging to region 1 and region 3 respectively. WGA tests for three different samples given the population named 1908 individuals: all individuals with and without covariate (methods=pcal (see figure 1) and all respectively), and those belonging to regions 1 (method=region-l) and 3 (method=region-3). The table contains the results of WGA tests on the following phenotypes: albuminuria, myocardial infarction, stroke, and all complications combined. SNPs selected have p-value <5xl0e-04. Quality filters: minor allele frequency, MAF 0.01, HWE 0.001, call rate 0.98. Determination of the risk allele for OR: If the minor allele frequency is higher in cases than in controls, the minor allele is defined as the risk allele.

[0151] Table 2: Flanking sequences of each of the SNPs listed in Table 1.

[0152] Table 3. list of all genes relevant to the whole genome association results of Table 1. The relevance here means that one on more of the SNPs listed in Table 1 are located either inside the gene (exon, intron, 5 ¹ UTR, 3 ¹ UTR) or very close to the gene - as defined by NCBI.

[0153] Table 4. Myocardial infarction SNPs. In the first column (RS_ID), the official name of SNP according to dbSNP of NCBI is given; the second column (MARSHFILED) denotes the position of SNP in cM on the respective chromosome. METHOD encompasses the association model type (linear or logistic regression) and covariates used in the model (HBP...hypertension, GE...geoethnic structure as determined by principal components 1 and two of PCA analysis, ACR...albumin/creatinine ratio, CRCL...creatinine clearance, AGE and SEX). PHENOTYPE denotes the case and control setup as described above. CHR identifies chromosomal allocation of the SNPs. P-VALUE shows the p value and OR_ALL denotes allelic odds ratio

[0154] Table 5. Flanking sequences of each of the SNPs in Table 4. The table comprises the the

official name of SNP according to dbSNP of NCBI (dbSNP RS ID) and the flanking sequence as retrieved from queries to Affymetrix NetAffx™ Analysis Center for the SNPs included in Table 4.

[0155] Table 6. Genes related to MI SNPs from Table 4. The table shows the official symbol (GENE_SYMBOL) and name of the genes (Gene Name) according to Human Genome Organisation Gene Nomenclature Committee for the genes relevant to the whole genome association results of 1908 individuals in Table 4. The relevance here means that one on more of the SNPs listed in Table 4 are located either inside the gene (exon, intron, 5'UTR, 3'UTR) or very close to the gene - as defined by NCBI.

[0156] Table 7. Kidney related complication (qualitative phenotypes) SNPs. In the first column (RS_ID), the official name of SNP according to dbSNP of NCBI is given; the second column (MARSHFILED) denotes the position of SNP in cM on the respective chromosome. METHOD encompasses the association model type (linear or logistic regression) and covariates used in the model (HBP... hypertension, GE...geoethnic structure as determined by principal components 1 and two of PCA analysis, AGE and SEX). PHENOTYPE denotes the case and control setup as described above. CHR identifies chromosomal allocation of the SNPs. P- VALUE shows the p value and OR-ATT. denotes allelic odds ratio.

[0157] Table 8. Flanking sequences of each of the SNPs in Table 7. The table comprises the official name of SNP according to dbSNP of NCBI (dbSNP RS ID) and the flanking sequence as retrieved from queries to Affymetrix NetAffx™ Analysis Center for the SNPs included in Table 7.

[0158] Table 9. Genes related to kidney SNPs from Table 7. The table shows the official symbol (GENE_SYMBOL) and name of the genes (Gene Name) according to Human Genome Organisation Gene Nomenclature Committee for the genes relevant to the whole genome association results of 1908 individuals in Table 7. The relevance here means that one on more of the SNPs listed in Table 7 are located either inside the gene (exon, intron, 5'UTR, 3'UTR) or very close to the gene - as defined by NCBI.

[0159] Table 10. Kidney related complication (quantitative phenotypes) SNPs. In the first column (RS_ID), the official name of SNP according to dbSNP of NCBI is given; the second column (MARSHFIELD) denotes the position of SNP in cM on the respective chromosome. METHOD encompasses the association model type (Linear or logistic regression) and covariates

used in the model (HBP... hypertension, GE...geoethnic structure as determined by principal components 1 and two of PCA analysis, AGE and SEX). PHENOTYPE denotes the case and control setup as described above. CHR identifies chromosomal allocation of the SNPs. P- VALUE shows the p value.

[0160] Table 11. The table comprises the official name of SNP according to dbSNP of NCBI (dbSNP RS ID) and the flanking sequence as retrieved from queries to Affymetrix NetAffx™ Analysis Center for the SNPs included in Table 10.

[0161] Table 12. The table shows the official symbol (GENE_SYMBOL) and name of the genes (Gene Name) according to Human Genome Organisation Gene Nomenclature Committee for the genes relevant to the whole genome association results of 1908 individuals in Table 10. The relevance here means that one on more of the SNPs listed in Table 10 are located either inside the gene (exon, intron, 5'UTR, 3'UTR) or very close to the gene - as defined by NCBI.

[0162] Table 13: list of the SNPs used for geoethnic clustering (14,961 SNP example).

[0163] Table 14: list of the SNPs used for geoethnic clustering. (2 000 PCA set).

[0164] Table 15: Fraction of the 1904 individuals correctly classified clusters compared to baseline reference of 147691 SNPs.

[0165] Table 16: list of SNPs selected using SVM method and their flanking sequence.

[0166] Table 17: Mean area under the ROC curve (AUC) and 95% CI for the classification of major cardiovascular complications based on 1000 bootstrap iterations for two models: Only SNPs and SNPs + biomarkers.

[0167] Table 18: Mean area under the ROC curve (AUC) and 95% CI for the classification of major cardiovascular complications based on 1000 bootstrap iterations for two models: each biomarkers independently and biomarkers added one by one.

[0168] Table 19: list of SNPs selected using bootstrap method and their flanking sequence.

[0169] Table 20: list of SNPs comprised in the genes of Table 21.

[0170] Table 21: list of genes previously reported to be related to complications of T2D.

[0171] Without further elaboration, it is believed diat one skilled in the art can, using the preceding description, utilώe the following invention to its fullest extent. The following specific preferred embodiments are, therefore, to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever.

[0172] In the forgoing and in the following examples, all temperatures are set forth uncorrected in degrees Celsius and, all parts and percentages are by volume, unless otherwise indicated.

[0173] Experimental method

[0174] Over the last year several studies have reported significant associations of single nucleotide polymorphisms (SNP) using Whole Genome Scans (WGS) in several areas, including myocardial infarction and T2D, while hypertension appeared to resist genomic resolution at SNP level. Here we analyzed the micro- and macro-vascular complications in type 2 diabetics at the entry of ADVANCE study. The current analysis is restricted to Caucasians to decrease the heterogeneity. Total 1908 subjects were included in this stage of genomic sub-study of ADVANCE. WGS was accomplished using Affymetrix chips (die GeneChip® Human Mapping 500K Array Set, Affymetrix Genome-Wide Human SNP Array 5.0 and Affymetrix Genome- Wide Human SNP Array 6.0) as per their progressive availability with excellent intra complementarity.

[0175] This section describes the complete experimental mediod used by the inventors aiming to discover genetic determinants of complications associated with T2D based on die following main points:

1. Demographic data

2. Genetic data

3. Subject quality filters

4. Genetic data quality filters

5. Analyses

6. Phenotype definitions

7. Association designs

1. Demographic data

1.1. Provenance — the demographic data is received from George Institute, Australia as Excel files via e-mail.

1.2. Validation — the demographic data files usually correspond to blood sample shipments and they are checked against those to see if they match. Any discrepancies are recorded and reported back via e-mail.

1.3. Compatibility - the data is further inspected for compatibility with the developed database insertion tool, as some small changes may be required: dates format to: yyyy-mm-dd patient id column name to: new_id single quotes replaced by double quotes etc

All these modifications are logged then the files are saved as tab delimited text files for database import.

1.4. Database insertion — the insertion is done using the PrognomixCmd (an in house developed software for interfacing with PostgreSQL and R statistical package) and phenotype insertion command files. The files, their output and the generated insertion SQL commands are logged for traceability. The data is inserted into Prognomix database into person, viήt, measure, medication and medical tables.

1.5. Insertion validation - once the data is inserted, the database is queried for several random pheno types and the output is compared, manually, with the received Excel files.

2. Genetic data

2.1. Provenance - the genetic data is produced by the lab team using the blood samples from Australia and Affymetrix genotyping platform. Several chips are used: the GeneChip® Human Mapping 500K Array Set, Affymetrix Genome-Wide Human SNP Array 5.0 and Affymetrix Genome-Wide Human SNP Array 6.0 and the output consists of multiple data files per sample (subject):

DAT file — contains the raw scanned image CEL file — the normalized image — used to calls the SNP XML file - contains experiment related information - JPEG file - the normalized image compressed as a jpeg file.

All these files are compressed and archived on DVDs.

2.2. Sample quality check - the lab team employs a simple and fast sample quality check (DM).

2.3. SNP call — the CEL files (one per subject) are used to call the SNP genotypes for each subject for all SNPs. We use the software provided by Affymetrix, apt-probset-genotype software (version 1.4 for 500k chip and vl.8.5 64b for 5.0 and 6.0 chips), with default parameters corresponding to the chip type. The analysis script and application output are logged for further reference. The output consists in a huge matrix-like text file where the columns represent subjects and the lines markers (SNP) and a summary report file detailing some sample statistics as the genetically determined sex, sample call rate and global call rate. These metrics allows us to estimate the overall quality of the genotyping process. All subjects are called at once, as suggested by Affymetrix (personal communication, Nov 16 2007).

2.4. Database insertion — the genetic data database insertion is a two step process: (1) the matrix-like data file is converted in one per subject data file and (2) the individual data files are imported into the database. This process is again done using a SNP insertion script and the PrognomixCmd tool. The data is inserted into snp_genotype table.

2.5. Insertion validation - once the data is inserted, the database is queried for several random subjects and SNP then the output compared, manually, with the matrix-like SNP call file.

3. Subject quality filters

Subjects may be excluded for subsequent analyses. When the sex determined through genotyping does not match the sex provided in demographic data, a request is made to the George Institute to check the sex. If the re-checked sex matches die genotypic sex, die sex is corrected in die database and the subject is kept. However, if die re-checked sex does not match the genotypic sex, the subject is excluded from further analyses (table issues). Subjects whose genome proportion from the Caucasian ancestral population is below 80% according to the average of 5 STRUCTURE β. P. Huelsenbeck, P. Andolfatto, Inference of Population Structure Under a Oiriώkt Process Model, 2007 175:1787-18027 runs (see below) are excluded from furdier analyses.

4. Genetic data quality filters

SNPs considered for further analyses must pass all the following criteria:

4.1. Call rate — the SNP call rate threshold over all genotype subjects was set at 97%.

4.2. Minor allele frequency (MAF) - the SNP MAF threshold over all genotyped subjects was set to 1%.

4.3. Hardy-Weinberg equilibrium (HWE) - the HWE is computed for all subjects and for each affection separately for cases and controls. For single SNP tests like association we filter on controls FTWE p-value using a threshold of 10 ^"4 when reporting results. For global analyses involving many SNPs (like principal component), we filter out SNP based on all subjects HWE p-value. The cutoff was set to 10 ^"4 for PCA implemented in EIGENSTRAT [Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich. Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics, Vol. 38, No. 8. (23 July 2006), pp. 904-909.] and 10 ^"4 for PCA implemented in R.

4.4. Batch genotype frequency differences - since we used several different chips for genotyping, we noticed a number of SNPs which had completely different calls depending on the chip. To eliminate this situation we compared the chip genotypes frequency separately for cases and controls using a chi-square test and excluded SNPs showing p lower than 10 ^'4 .

4.5. Less reliable SNPs — 60k SNPs were considered less performing by Affymetrix and were masked on the Affymetrix Genome-Wide Human SNP Array 5.0. Although we can access these 60k SNPs they are filtered out.

Selected SNPs are then checked for the following:

4.6. SNP call clustering issues — we implemented a feature in PrognomixCmd tool which allows us to generate, store and examine the SNP call clusters for all SNPs and subjects. SNPs showing bad clusters according to the following criteria are filtered out: no clearly defined clusters only two clusters two clusters called very far from the third one two distinct clusters called the identical the calls assigned by algorithm different from those we'd assign by visual inspection.

5. Analyses

5.1. Coarse-grain stratification — using STRUCTURE 2.2. All subjects ate analysed together. 5 different sets of SNPs were used in order to assess the variability in the results due to the choice of the SNPs. Each set contains around 400 SNPs, chosen according to the following criteria: (1) on autosomes; (2) found in Perlegen, HapMap and Affymetrix data sets; (3) spaced at least 5 MB apart; (4) showing Fst > 0.2 according to Perlegen (genome.perlegen.com/data); (4) same strand is used by Affymetrix and HapMap. The 210 founder HapMap subjects are included in the analysis (60 children are discarded). The following parameters are used: (1) 10,000 burnin iterations; (2) 50,000 real iterations; (3) 3 populations assumed; (4) admixture allowed; (5) no information about origin of subjects provided.

5.2. Fine grain stratification: PCA analysis was performed using eidier in house developed software or die SMARTPCA module of Eigensoft (ref: Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich. Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics, Vol. 38, No. 8. (23 July 2006), pp. 904-909). The two first principal components (i.e. those that explained most of die variance) were used when PCA was included as a covariate in the association analyses.

5.3. Selection of covariates: We used Random Forest (Breiman L (2001). Random Forests, Machine Learning, 45: 5-32.) to adjust for unknown stratification or confounding factors in the reported associations by selecting covariates susceptible to inflate p-values. Random Forests is a machine learning approach based on classification and regression tree methods which offers the advantage of being robust against overfitting. Every tree is built using a bootstrap sample of all the subjects and, at each node of the tree, a random subset (parameter mtry) of all predictors (covariates) is chosen to determine die best split radier dian die whole set of predictors. For each tree, approx. one third of all subjects are excluded from the bootstrap sample, also referred to as "out-of-bag" or OOB subjects, and diese subjects are used to estimate prediction accuracy of the Random Forest. The Random Forest mediod also produces an importance measure for each predictor, which quantifies die relative contribution of each predictor to the prediction accuracy. For each phenotype, we selected covariates based on importance measures estimated from 2000 trees "grown" in the randomForest R package version 4.5-28 ( Iiaw A, Wiener M (2002). Classification and Regression by random Forest, R News 2(3): 18—22.). Parameter mtry was set equal to the square root of the number of

predictors used to grow the forest (default value). We imputed missing values in the set of predictors using function rflmpute implemented in the package.

5.4. Single SNP association — this kind of test was done using the PrognomixCmd tool or the Prognomix Discovery Support tool and one of the four implemented association types:

5.4.1. binary association — consists in an Armitage trend test for additive, dominant and recessive models, a chi-square or Fisher test for the allelic model and a 2 by 3 chi- square test for the genotypic model. These tests are implemented in the R library assoc by the function snp.chisq and in the PLINK [Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, Mailer J, Sklar P, de Bakker PIW, Daly MJ & Sham PC. (2007).PLINK: a toolset for whole-genome association and population-based linkage analysis. American Journal of Human Genetics, 81.] tool by the function —assoc -geno.

5.4.2. continuous association — performs parametric or non parametric tests depending on the normality of the analysed trait (tested with a Shapiro- WiIk test) and the model: additive model — linear regression. dominant, recessive or allelic models — T-test or Wilcoxon test, genotypic model — Anova or Kruskal-Wallis tests. These tests are implemented in the R library assoc by the function assoc.cont.

5.4.3. linear regression association for quantitative traits with covariates — uses a linear regression model to test for association for all five models, possibly using covariates. These tests are implemented in the R library assoc by the function assoc.model by specifying a Gaussian regression model and in the PLJNK tool by the function --linear.

5.4.4. logistic regression association for binary traits with covariates — uses a logistic regression model to test for association for all five models, possibly using covariates. These tests are implemented in the R library assoc by the function assoc.model 'by specifying a Binomial regression model and in the PLINK tool by the function --logistic.

All four association types involve several similar steps, which can be all done using PrognomixCmd tool or the Prognomix Discovery Support tool and association command files: Trait data extraction — the qualitative or quantitative trait data is extracted form database for all subjects or for a subset of them into text files and transferred on the computation server.

Genetic data extraction — the genetic data is extracted form database, generally for all markers (sometimes only for a chromosome or a list of selected SNPs).

Test — the test is performed on the computation server using custom developed R library assoc. or PLINK.

Database results insertion - the results generated by the tests are transferred back from the computation server, and then inserted into Prognomix database or stored using the data storage functionality of the Prognomix Discovery Support tool.

Result reporting - the best results are extracted from database using predefined or custom defined quality filters and reported into Excel files. The interesting results are further investigated for non-automated quality filters (clusters) as described above.

All the analysis scripts and the application output are logged for further reference or audit.

5.5. Haplotype association — this test was only performed in genomic regions of interest using several different methods:

5.5.1. Find haplotype blocks in HapMap CEU population then use the blocks in our population to test for association using HaploView with the default parameters. HaploView. estimates haplotypes using an estimation-maximization (EM) approach then test association using a chi-square test for each haplotype.

5.5.2. Find haplotype blocks in HapMap CEU population then use the blocks in our population to test for association using the R library Haplo.Stats. Haplo.Stats uses an EM haplotype inference algorithm which incorporates the haplotype phase uncertainty rather than assigning a most likely haplotype to each sample then test for association using a generalized linear regression model.

5.5.3. Use the sliding window approach implemented in PLJNK with different windows sizes inside which the haplotypes are estimated using an EM approach, then the association is tested with a chi-square test for each haplotype.

5.5.4. Use the tag SNP identification method implemented in idSelect, which create haplotypes with tag SNPs and test for association using Haplo.Stats as above. IdSelect identifies tag SNP based on linkage disequilibrium statistic r ² and a greedy algorithm by grouping SNPs into bins of associates sites where the pair wise r ² is above a threshold. One SNP per bin is the tag SNP.

Phenotype definitions

Two sets of phenotype definitions were used.

The first set was based on the initial definitions used at baseline of the ADVANCE study and was as follow:

6.1. Stroke: cerebrovascular accident before or at the entry to ADVANCE (ADVANCE definition: Damage to blood vessels in the brain where vessels burst and bleed or become clogged with fatty deposits. When blood flow is interrupted, brain cells die or are damaged, resulting in a stroke.)

6.2. Myocardial infarction: heart attack before or at the entry to ADVANCE (ADVANCE definition: The medical term for heart attack, which occurs when the blood supply to part of the heart muscle itself - the myocardium — is severely reduced or stopped, resulting in the death of a segment of the heart muscle.)

6.3. Albuminuria: albumin/creatinine ratio is equal or higher than 30μg/mg at the entry to ADVANCE (ADVANCE definition: The presence of albumin in the urine that is usually a symptom of disease of the kidneys.)

6.4. Complications: Stroke and/or myocardial infarction and/or albuminuria as defined above.

6.5. No Complications: None of the above complications.

The second set of definitions was established after inclusion of follow up data obtained during the conduct of the ADVANCE study and was as follow:

6.6. Controls are T2D that at the entry to ADVANCE study had no history of or were not diagnosed with: myocardial infarction, hospitalization for unstable angina, stroke, transitory ischaemic attack, atrial fibrillation, heart failure, left ventricular hypertrophy, background retinopathy, blindness, macular oedema, proliferative retinopathy, retinal photocoagulation therapy, peripheral revascularization, amputation, estimated glomerular filtration rate below 60mL/min/1.73 m ² , and albumin/creatinine ratio higher than 30 μg/mg.

6.7. Supercontrols are a subset of controls that did not have any macrovascular (cardiovascular death, myocardial infarction, stroke) or microvascular [new or worsening nephropathy (macroalbuminuria — albumin/creatinine tio higher than 300 μg/mg; high serum creatinine - higher than 200 μmol/L; need for renal replacement therapy; death

due to renal disease), retinopathy (proliferative retinopathy, macular oedema, blindness, history of retinal coagulation therapy] events during the duration of ADVANCE study.

6.8. Myocardial infarction: Heart attack and/or Q-waves diagnostics of previous myocardial infarction and/or hospitalization for unstable angina

6.9. AJbumin/creatinine ratio: quantitative trait (units μg/mg)

6.10. Albuminuria: albumin/creatinine ratio is equal or higher than 30μg/mg

6.11. Microalbuminuria: albumin/creatinine ratio is equal or higher than 30μg/mg and lower than 300μg/mg

6.12. Macroalbuminuria: albumin/creatinine ratio is equal or higher than 300μg/mg

6.13. Estimated glomerular filtration rate: quantitative trait (units mL/min/1.73 m ² )

6.14. Low estimated glomerular filtration rate: values below 60 mL/min/1.73 m ²

6.15. New worsening nephropathy event: macroalbuminuria (albumin/creatinine ratio higher than 300μg/mg) and/or high serum creatinine (higher than 200μmol/L) and/or need for renal replacement therapy and/or death due to renal disease) during the ADVANCE study

7. Association designs

Using the first set of phenotypes we performed analysis based on the designs listed below. The results of these analyses are provided in Tables 1, 2, and 3. Table 1 provides the SNPs IDs, details of the phenotypes and covariates used during analysis and p values and odds ratios obtained for each SNP. Table 2 provides the flanking sequence of the SNPs of Table 1 and Table 3 the genes related to the SNPs of Table 1.

Myocardial infarction vs. no myocardial infarction (see Table 1, phenotype = mi):

• Cases: Type 2 diabetic patients with heart attack before or at the entry to the ADVANCE study

• Controls: Type 2 diabetic patients without heart attack at the entry to the ADVANCE study

• Covariates: no covariates, geoethnicity-PCAl

Myocardial infarction vs. no myocardial infarction- patients from region 1 only

(see Table 1, phenotype = mi, region- 1)

• Cases: Type 2 diabetic patients from region 1 with heart attack before or at the entry to the ADVANCE study

• Controls: Type 2 diabetic patients from region 1 without heart attack at the entry to the ADVANCE study

• Covariates: no covariates

Myocardial infarction vs. no myocardial infarction — patients from region 3 only

(see Table 1 : phenotype = mi, region-3)

• Cases: Type 2 diabetic patients from region 3 with heart attack before or at the entry to the ADVANCE study

• Controls: Type 2 diabetic patients from region 3 without heart attack at the entry to the ADVANCE study

• Covariates: no covariates

Albuminuria vs. no albuminuria (see Table 1, phenotype = albu):

• Cases: Type 2 diabetic patients having albuminuria at the entry to the ADVANCE study

• Controls: Type 2 diabetic patients without albuminuria at the entry to the ADVANCE study

• Covariates: no covariates, geoethnicity-PCAl

Albuminuria vs. no albuminuria- patients from region 1 only (see Table 1, phenotype = albu, region-1)

• Cases: Type 2 diabetic patients from region 1 having albuminuria at the entry to the ADVANCE study

• Controls: Type 2 diabetic patients from region 1 without albuminuria at the entry to the ADVANCE study

• Covariates: no covariates

Albuminuria vs. albuminuria- patients from region 3 only (see Table 1, phenotype = albu, region-3)

• Cases: Type 2 diabetic patients from region 3 having albuminuria at the entry to the ADVANCE study

• Controls: Type 2 diabetic patients from region 3 without albuminuria at the entry to the ADVANCE study

• Covariates: no covariates

Complications vs. no complications (see Table 1, phenotype = complications)

• Cases: Type 2 diabetic patients having the above defined complications before or at the entry to the ADVANCE study

• Controls: Type 2 diabetic patients without the above defined complications at the entry to the ADVANCE study

• Covariates: no covariates, geoethnicity-PCAl

Complications vs. no complications- patients from region 1 only (see Table 1, phenotype = complications, region-1)

• Cases: Type 2 diabetic patients from region 1 having the above defined complications before or at the entry to the ADVANCE study

• Controls: Type 2 diabetic patients from region 1 without the above defined complications at the entry to the ADVANCE study

• Covariates: no covariates

Complications vs. no complications- patient from region 3 only (see Table 1, phenotype = complications, region-3)

• Cases: Type 2 diabetic patients from region 3 having the above defined complications before or at the entry to the ADVANCE study

• Controls: Type 2 diabetic patients from region 3 without the above defined complications at the entry to the ADVANCE study

• Covariates: no covariates

Stroke vs. no stroke (see Table 1, phenotype = stroke)

• Cases: Type 2 diabetic patients with stroke before or at the entry to the ADVANCE study

• Controls: Type 2 diabetic patients without stroke at the entry to the ADVANCE study

• Covariates: no covariates, geoethnicity-PCAl

Stroke vs. no stroke— patients from region 1 only (see Table 1, phenotype = stroke, region-1)

• Cases: Type 2 diabetic patients from region 1 with stroke before or at the entry to the ADVANCE study

• Controls: Type 2 diabetic patients from region 1 without stroke at the entry to the ADVANCE study

• Covariates: no covariates

Stroke vs. no stroke— patients region 3 only (see Table 1, phenotype = stroke, region-

3)

• Cases: Type 2 diabetic patients from region 3 with stroke before or at the entry to the ADVANCE study

• Controls: Type 2 diabetic patients from region 3 without stroke at the entry to the ADVANCE study

• Covariates: no covariates

Using the second set of phenotypes we performed analysis based on the designs listed below. For myocardial infarction, the results of these analyses are provided in Tables 4, 5, and 6. Table 4 provides the SNPs IDs, details of the phenotypes and covariates used during analysis and p values and odds ratios obtained for each SNP. Table 5 provides the flanking sequence of the SNPs of Table 4 and Table 6 the genes related to the SNPs of Table 4. For kidney disease (qualitative phenotypes), the results of these analyses are provided in Tables 7, 8, and 9. Table 7 provides the SNPs IDs, details of the phenotypes and covariates used during analysis and p values and odds ratios obtained for each SNP. Table 8 provides the flanking sequence of the SNPs of Table 7 and Table 9 the genes related to the SNPs of Table 7. For kidney disease (quantitative phenotypes), the results of these analyses are provided in Tables 10, 11, and 12. Table 10 provides the SNPs IDs, details of the phenotypes and covariates used during analysis and p values and odds ratios obtained for each SNP. Table 11 provides the flanking sequence of the SNPs of Table 10 and Table 12 the genes related to the SNPs of Table 10.

• Myocardial infarction before or at the entry to ADVANCE versus no myocardial infarction before or at the entry to ADVANCE (see Table 4, phenotype = MI vs no MI (at entry))

• Cases: Type 2 diabetic patients having myocardial infarction before or at the entry to ADVANCE study

• Controls: Type 2 diabetic patients free of myocardial infarction at the entry to ADVANCE study

• Covariates: no covariates; age + sex; age + sex + geoethnicity; age + sex + geoethnicity + status of being currently treated for hypertension; age + sex + geoethnicity + albumin/creatinine ratio; age + sex + geoethnicity + estimated glomerular filtration rate

• Myocardial infarction before or at the entry to ADVANCE versus clean controls

(see Table 4, phenotype = MI vs control (at entry))

• Cases: Type 2 diabetic patients having myocardial infarction before or at the entry to ADVANCE study plus any other condition/ disease

• Controls: controls as defined above

• Covariates: no covariates; age + sex; age + sex + geoethnicity; age + sex + geoethnicity + status of being currently treated for hypertension; age + sex + geoethnicity + dbumin/creatinine ratio; age + sex + geoethnicity + estimated glomerular filtration rate

• Myocardial infarction before and/or during the ADVANCE study versus no myocardial infarction before and during the ADVANCE study (see Table 4, phenotype = MI vs no MI (follow-up))

• Cases: Type 2 diabetic patients having myocardial infarction before and/or during the ADVANCE study

• Controls: Type 2 diabetic patients free of myocardial infarction before and during the ADVANCE study

• Covariates: no covariates; age + sex; age + sex + geoethnicity; age + sex + geoethnicity + status of being currently treated for hypertension; age + sex + geoethnicity + albumin/creatinine ratio; age + sex + geoethnicity + estimated glomerular filtration rate

• Myocardial infarction before and/or during the ADVANCE study versus supercontrols (see Table 4, phenotype = MI vs control (follow-up))

• Cases: Type 2 diabetic patients having myocardial infarction before and/or during the ADVANCE study plus any other condition/disease

• Controls: Supercontrols as defined above

• Covariates: no covariates; age + sex; age + sex + geoethnicity; age + sex + geoethnicity + status of being currently treated for hypertension; age + sex + geoethnicity + albumin/creatinine ratio; age + sex + geoethnicity + estimated glomerular filtration rate

• Albumin/creatinine ratio as a quantitative trait (see Table 10, phenotype = Albumin/Creatinine ratio at entry)

• Covariates: no covariates; age + sex; age + sex + geoethnicity

• Estimated glomerular filtration rate as a quantitative trait (see Table 10, phenotype = Creatinine Clearance at entry)

• Covariates: no covariates; age + sex; age + sex + geoethnicity

• Albuminuria at the entry to ADVANCE versus no albuminuria at the entry to

ADVANCE (see Table 7, phenotype = albuminuria vs. no albuminuria (at entry))

• Cases: Type 2 diabetic patients having albuminuria at the entry to ADVANCE

• Controls: Type 2 diabetic patients widiout albuminuria at die entry to ADVANCE

• Covariates: no covariates; age + sex; age + sex + geoedinicity

• Albuminuria at the entry to ADVANCE versus clean controls (see Table 7, phenotype = microalbuminuria or macroalbuminuria vs. control (at entry))

• Cases: Type 2 diabetic patients having albuminuria at die entry to ADVANCE

• Controls: controls as defined above

• Covariates: no covariates; age + sex; age + sex + geoethnicity

• Microalbuminuria at the entry to ADVANCE versus no albuminuria at the entry to ADVANCE (see Table 7, phenotype = microalbuminuria vs. no albuminuria (at entry))

• Cases: Type 2 diabetic patients having microalbuminuria at the entry to ADVANCE

• Controls: Type 2 diabetic patients without albuminuria at die entry to ADVANCE

• Covariates: no covariates; age + sex; age + sex + geoedinicity

• Macroalbuminuria at the entry to ADVANCE versus no albuminuria at the entry to ADVANCE (see Table 7, phenotype = macroalbuminuria vs. no albuminuria (at entry))

• Cases: Type 2 diabetic patients having macroalbuminuria at die entry to ADVANCE

• Controls: Type 2 diabetic patients without albuminuria at die entry to ADVANCE

• Covariates: no covariates; age + sex; age + sex + geoedinicity

• Albuminuria at the entry and/or during the ADVANCE study versus no albuminuria at the entry and during the ADVANCE study (see Table 7, phenotype

= albuminuria vs. no albuminuria (follow-up))

• Cases: Type 2 diabetic patients having albuminuria at the entry and/or during the ADVANCE study

• Controls: Type 2 diabetic patients without albuminuria at the entry and during the ADVANCE study

• Covariates: no covariates; age + sex; age + sex + geoethnicity

• Albuminuria at the entry and/or during the ADVANCE study versus supercontrols (see Table 7, phenotype = microalbuminuria or macroalbuminuria vs. control (follow-up))

• Cases: Type 2 diabetic patients having albuminuria at the entry and/or during the ADVANCE study

• Controls: supercontrols as defined above

• Covariates: no covariates; age + sex; age + sex + geoethnicity

• Low estimated glomerular filtration rate at the entry to ADVANCE study versus no low estimated glomerular filtration rate at the entry to ADVANCE study (see Table 7, phenotype = low creatinine clearance vs. normal creatinine clearance)

• Cases: Type 2 diabetic patients having low estimated glomerular filtration rate at the entry to ADVANCE study

• Controls: Type 2 diabetic patients not having low estimated glomerular filtration rate at the entry to ADVANCE study

• Covariates: no covariates; age + sex; age + sex + geoethnicity

• Low estimated glomerular filtration rate at the entry to ADVANCE study versus clean controls (see Table 7, phenotype = low glomerular filtration rate vs. control (at entry))

• Cases: Type 2 diabetic patients having low estimated glomerular filtration rate at the entry to ADVANCE study

• Controls: controls as defined above

• Covariates: no covariates; age + sex; age + sex + geoethnicity

• Low estimated glomerular filtration rate at the entry to ADVANCE and/or new worsening nephropathy event during the ADVANCE study versus no low estimated glomerular filtration rate at the entry and no new worsening nephropathy event during ADVANCE study (see Table 7, phenotype = low glomerular filtration rate vs. normal glom. filtration rate (follow-up))

• Cases: Type 2 diabetic patients having low estimated glomerular filtration rate at the entry to ADVANCE study and/or new worsening nephropathy event

• Controls: Type 2 diabetic patients not having low estimated glomerular filtration rate at the entry to ADVANCE study and no new worsening nephropathy event

• Covariates: no covariates; age + sex; age + sex + geoethnicity

• Low estimated glomerular filtration rate at the entry to ADVANCE and/or new worsening nephropathy event during the ADVANCE study versus supercontrols

(see Table 7, phenotype = low glomerular filtration rate vs. control (follow-up))

• Cases: Type 2 diabetic patients having low estimated glomerular filtration rate at the entry to ADVANCE study and/or new worsening nephropathy event

• Controls: supercontrols as defined above

• Covariates: no covariates; age + sex; age + sex + geoethnicity

EXAMPLES

The invention will be explained below with reference to the following non-limiting examples.

Example 1

[0176] Geoethnic clustering.

[0177] It is has been shown that we can distinguish without any overlap Caucasians, Africans and Asians. Given the density of the currently available genomic markers and the power of our study, we demonstrated that we can distinguish individuals of Caucasian origin within European populations. Our data show that using a subset of 14,961 SNPs (list in provided in Table 13) unrelated to T2D complications, we were able to cluster the individuals into three groups along the PCl and PC2 axes (FIG 1): Group 1 (n= 1317 individuals) , Group 2 (n= 80) and Group 3 (n= 507). The two predominant populations (Group 1 and Group 3) exhibit a west/ east cline in Europe and a majority of the western type (Group 1) were found in Australia, New-Zealand and Canada (FIG. 2). It is relevant to state here that population in Eastern Europe (Group 3) present a higher prevalence of complications such as and not limited to albuminuria, hypertension, stroke and myocardial infarction (FIG.3). The observed excess of complications in predominantly Eastern regions (Group 3) is mainly related to the higher frequency of risk alleles compared to Western regions (Group 1) (FIG 4A-C, example of SNPs on chr 2 for albuminuria, all complications and MI). The figure shows same impact in an individual independently of environment, but higher allele frequency in population 3. Occurring less frequendy, the increased disease prevalence (albuminuria or stroke) is at least partially dependent on die allele penetrance (albuminuria on chr6 and stroke on chrll) (i.e., the frequency is similar in groups 1 and 3, but the impact on the individual is more severe in his/her genomic in population 1 for stroke and population 3 for albuminuria). See, FIG. 4 D and E. The test should thus be appropriately tailored to identify the geo-ethnic specificity by including SNPs among the 14,961 identified in our studies. There is a two prone importance for this finding. 1) a public health relevance modifying the public health strategies as a result of the knowledge of the risk in specific population and 2) at the level of the individual and of his or her relatives, where the impact may require specific individualized approach of prevention and treatment. [0178] Further demonstration of the power of the method can be shown by assessing the effect of varying the number of SNPs used on the accuracy of the classification.

[0179] The fine grain stratification analysis consisted of the following steps: 430 205 Affymetrix SNPs that are common to Affymetrix Genome- Wide Human SNP Array 5.0 and Affymetrix Genome-Wide Human SNP Array 6.0 were filtered using PLINK SNP filters which consists of a minor allele frequency (MAF) superior to 0.01, a missing individual call rate (MIND) of at most 0.1, a SNP call rate of at least 0.98 and a Hardy-Weinberg equilibrium threshold of 0.001. After

the filters were applied, the 350 895 resulting SNPs were scanned for LD using an R-squared threshold of 0.8 and PLINK. The final number of SNPs was 147691 and all of them were fed to SMARTPCA version 7521 of EIGENSOFT 2.0 (Alkes L Price, Nick J Patterson, Robert M Plenge, Michael E Weinblatt, Nancy A Shadick, David Reich. Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics, Vol. 38, No. 8. (23 July 2006), pp. 904-909) to obtain the principal components number 1 and 2. [0180] The fine grain principal component analysis using only 2 000 SNPs consisted of the following steps: 1) run the analysis for 147 691 SNPs (see above) and then obtain the SNP weights (loadings) for PCl and PC2 from SMARTPCA; 2) use the PCl and PC2 weights to derive a combined score as the following: SCORE = absolute value (PCl) + absolute value(PC2) 3) remove the rightmost percentile of the combined score distribution to remove any artifacts that could influence the procedure when using a small number of SNPs; 4) starting from the rightmost distribution of the combined scores, define sets of SNPs as the first 50, 100, 500, 1000, 2000, 5000 and 10000; 5) Run SMARTPCA to obtain the PCl and PC2 values for every set of SNPs; 6) Run K-means clustering (in house method) on the fine grain stratification of the 147691 SNPs to obtain 3 specific clusters; 7) repeat this procedure for the sets of SNPs defined above (50, 100, 500, 1000, 2000, 5000 and 10000); 8) obtain cluster classification accuracy by comparing the cluster assigned to each individual from every set of SNP versus the reference clusters of the PCA run with 147691 SNPs (see table 15). The lowest number of SNPs which yields 99% classification accuracy is 2000 (listed in table 14).

[0181] The models obtained from either 500 to 147691 SNPs could be used to assign newly obtained patients to a geographic location. This could imply geographic-specific conclusions incorporated into our prediction tool.

Example 2

[0182] Combination of SNPs

[0183] Demonstration of the predictive power of the SNP provided in tables 1, 4, 7 and 10 could be made by combining several of those SNP markers selected based on their level of association with diabetes complications and on the frequency of their risk or protective alleles in the population. Several methods are known by those skilled in the art to select appropriate markers.

[0184] Particularly preferred are combinations of biomarkers provided in tables 16 and 19.

[0185] Prediction models rely on training and testing sets or bootstrap procedures. Two different models of classification were used: logistic regression and support vector machines. Logistic regression is a well known method which models the probability of a binary variable representing the outcome of interest (event vs. non-event) as a function of quantitative and/or categorical predictors. Support vector machine searches for optimal hyperplanes that separate two classes (here cases and controls) by maxinuzing the margin between the classes' closest points.

[0186] Support vector machines. A subset of discriminative SNPs resulting from GWA association tests should be able to correctly classify the complications related to T2D at an acceptable area under the "Receiver Operating Characteristics" (ROC) curve (AUC) accuracy (0.75) considered between random classification (0.5) and perfect classification (1.0). Based on the hypothesis that a signature found on all observations will classify with acceptable accuracy subsets of individuals composing the whole set, a model was constructed by adding the 1000 most significant SNPs from genome wide associations (p-value) performed on all individuals. Our initial results on T2D complications show that the AUC increases to 0.9 as the number of the best associated SNPs increases to 1000. Association analyses were set to automatically exclude SNPs on the basis of missing genotype rate, with the PLINK — geno option. We included SNPs with at least 98% genotyping rate (2% missing). Given that prediction methods have a hard time or do not deal with missing data, we performed genotype imputation with fastPHASE Vl .2.3. [ Stephens, M., Smith, N., and Donnelly, P. (2001). A new statistical method for haplotype reconstruction from population data. American Journal of Human Genetics, 68, 978 — 989] Adding SNPs not- associated to complications never increased the predictive accuracy of the method (Figure 5). From the top 5 000 associated SNPs in the entire dataset we identified 95 independent SNPs (listed in Table 13) maintaining 0.85 predictive value using INTERACT (Zheng, Zhao. Searching or Interacting Features, In Proc. of International Joint Conference on Artificial Intelligence (IJCAI), January, 2007). (Figure 6). Using ADVANCE data, we thus demonstrated for the first time significant genomic determinants of vascular complications of diabetes.

[0187] Logistic regression. We used a bootstrap procedure that samples with replacement from the whole dataset during 1000 iterations [I) Angelo Canty and Brian Ripley (2009). boot: Bootstrap R (S-Plus) Functions. R package version 1.2-35. 2) Davison, A. C. & Hinkley, D. V. (1997) Bootstrap Methods and Their Applications. Cambridge University Press, Cambridge]. The AUC

reported is the mean from all the bootstrap iterations and a confidence interval was constructed at 95%. The experience was repeated on four different models: only SNPs (top 250 associated SNPs from GWA of myocardial infarction), combined biomarkers and SNPs, only biomarkers added one at a time and each biomarker separately. Examples of biomarkers used for classification include, but are not limited to, age of diagnosis, diabetes duration at baseline, cigarette smoking, systolic blood pressure, atrial fibrillation, glycated hemoglobin (HbAl, _; ), total cholesterol, HDL cholesterol and sex. The figure 7 and tables 14 and 15 shows the AUC in function of the number of SNPs and the number of biomarkers by model. The highest classification accuracy of simple biomarkers is achieved by smoking and systolic blood pressure. The predictive accuracy of a model containing all the biomarkers in an additive manner gets an AUC of 0.72. The classification accuracy obtained with 250 best associated SNPs (table 16) is almost similar to the one acquired by a combination of biomarkers and the same number of SNPs (AUC 98%).

Example 3

[0188] Selection of patients for clinical trials of T2D drugs

[0189] Application of a classification tool in selecting patients with higher risk for T2D complications could dramatically reduce the sample size (and/or the time and cost) required to perform clinical outcome studies in T2D. In our estimations we assumed the following scenario. A randomized clinical trial with two arms is designed to test the impact of novel antidiabetic medication on the rate of cardiovascular events in T2D patients. In one arm, patients receive the usual medication (control arm) whereas, in the other arm (treatment arm), patients receive the novel antidiabetic medication in top of the usual medication. The number of samples required in both arms is such that a difference of 20% between the two arms respective annual event rates will be detected with 80% power at a fixed significance level of 5%. The trial is planned for 5 years.

[0190] Figure 8 shows the impact of the annual event rate in the control arm on the number of patients which need to be enrolled at entry. In the graph is shown the observed 3.2% annual event rate of MACE in the ADVANCE trial. Based on a general population of diabetics, the number of subjects needed to achieve the required number of MACE events, widiout applying any selection criteria at entry, would be ~60 000 subjects. Using SNPs selected from those listed in tables 1, 4, 7, 10, 13, 14, 16 and 19 of the present invention, with or without other biomarkers, to select patients for such a trial will considerably decrease the number of subjects to recruit in

the trial. As an example, increasing AUC from 65% to 85% would reduce the number of required subjects to be enrolled at entry from 11,145 to 2,475 in order to obtain the same number of events during the clinical trial. Similar scenarios may be envisioned for outcome studies for other classes of novel therapies using this approach and, if determining the rate of cardiovascular events is the objective, using SNPs selected from those listed in tables 1, 4, 7, 10, 13, 14, 16 and 19 of the present invention.

[0191] The preceding examples can be repeated with similar success by substituting the genetically or specifically described reactants and/or operating conditions of this invention for those used in the preceding examples.

[0192] From the foregoing description, one skilled in the art can easily ascertain the essential characteristics of this invention and, without departing from the spirit and scope thereof, can make various changes and modifications of the invention to adapt it to various usages and conditions. All publications and patents cited above are incorporated herein by reference.

Table 1

RSJD MARSHFIELD METHOD PHENOTYPE CHR P-Value OR_ALL rs17095265 102.47974401109 all mi 1 9.81 E-05 0.470787985 rs17095265 102.47974401109 peal mi 1 1.47E-04 0.470787985 rs17095295 102.495355298991 peal mi 1 2.21 E-04 0.463569218 rs1252579 104.1567830063 region-1 stroke 1 9.68E-05 1.582414498 rs3766345 105.45895251257 all stroke 1 1.26E-05 1.342628585 rs3766345 105.45895251257 region-3 stroke 1 7.52E-05 1.737585616 rs473027 105.461744016086 all stroke 1 8.93E-05 1.258120957 rs1361196 113.144399777543 peal albu 1 2.34E-04 1.585566649 rs1416079 113.144656939512 peal albu 1 1.54E-04 1.606641497 rs1416078 113.14485996212 peal albu 1 1.88E-04 1.59527404 rs11163592 113.690210267218 all mi 1 1.28E-05 0.228166667 rs11163592 113.690210267218 peal mi 1 7.74E-05 0.228166667 rs11163592 113.690210267218 all stroke 1 9.72E-05 0.103113867 rs1077776 117.188972745823 region-3 mi 1 3.35E-06 0.229765215 rs17127881 118.081370367764 region-1 stroke 1 2.27E-05 1.292653309 rs17127881 118.081370367764 all stroke 1 8.60E-05 1.066295974 rs2791512 118.800885535497 peal albu 1 2.84E-04 1.338104709 rs166412 119.022090607117 all complications 1 9.29E-05 0.701776532 rs166412 119.022090607117 peal complications 1 3.49E-04 0.701776532 rs1265169 125.97614576733 all mi 1 8.36E-05 0.828008275 rs17021814 136.716261297317 region-3 complications 1 1.17E-05 0.354397507 rs17021814 136.716261297317 all stroke 1 3.14E-05 0.378795677 rs17021814 136.716261297317 region-3 stroke 1 3.14E-05 0.123555556 rs17021814 136.716261297317 peal stroke 1 8.64E-05 0.378795677 rs17021814 136.716261297317 all mi 1 3.30E-04 0.558783535 rs11185172 140.096843746906 all albu 1 8.93E-05 1.301013705 rs11185172 140.096843746906 peal albu 1 9.39E-05 1.301013705 rs1107392 146.106194767631 region-3 mi 1 7.62E-05 2.657258065 rs464357 146.6123827267 peal complications 1 4.53E-04 0.756496024 rs4504949 155.320190758724 peal mi 1 3.42E-04 1.623714467 rs17160205 155.320464336026 peal mi 1 4.10E-04 1.612354281 rs2916229 158.81411391893 all stroke 1 8.47E-05 1.252487562 rs13375397 164.477008165901 region-1 stroke 1 6.30E-06 2.329665394 rs13375397 164.477008165901 all stroke 1 3.77E-05 1.881931252 rs13375397 164.477008165901 peal stroke 1 5.39E-05 1.881931252 rs2789417 166.380868186606 all albu 1 5.89E-06 0.551230088 rs2789417 166.380868186606 peal albu 1 7.98E-06 0.551230088 rs2789416 166.382513165979 all albu 1 8.76E-06 0.556821895 rs2789416 166.382513165979 peal albu 1 1.37E-05 0.556821895 rs2840588 166.407226037918 peal albu 1 3.86E-04 0.582660343 rs7528328 170.75707337877 region-3 stroke 1 5.99E-05 1.968891485 rs7525955 170.757111937448 region-3 stroke 1 5.62E-05 1.976047904 rs6427673 172.531966140135 region-1 complications 1 9.31 E-05 1.234060762 rs6426898 176.470958045045 all stroke 1 8.81 E-05 0.816890166 rs932396 181.204433537209 all complications 1 8.96E-05 0.591770676 rs932396 181.204433537209 peal complications 1 1.03E-04 0.591770676 rs2860662 181.210083416897 all complications 1 7.38E-05 0.590898071 rs2860662 181.210083416897 peal complications 1 8.53E-05 0.590898071

Page 1 Table LxIs

rs2143300 181.210560491177 all complications 1 7.38E-05 0.590898071 rs2143300 181.210560491177 peal complications 1 8.53E-05 0.590898071 rs3766084 187.152189426183 region-1 stroke 1 8.90E-05 2.216949153 rs10489185 187.465998747321 all albu 1 9.12E-05 1.260491945 rs10489185 187.465998747321 region-3 albu 1 4.74E-04 1.43268789 rs3753305 187.471222599535 peal albu 1 4.25E-04 0.787865589 rs2205895 187.4900177488 all complications 1 4.36E-05 1.273365877 rs2205895 187.4900177488 all albu 1 4.62E-04 1.230824347 rs3917768 187.490323130792 all complications 1 1.42E-05 1.278449726 rs3917768 187.490323130792 region-3 albu 1 7.10E-05 1.592095977 rs3917768 187.490323130792 all albu 1 1.16E-04 1.259448605 rs3917768 187.490323130792 peal complications 1 3.98E-04 1.278449726 rs3917768 187.490323130792 region-3 complications 1 4.38E-04 1.505011472 rs1333147 188.340078858402 all mi 1 6.84E-05 1.200413572 rs6691444 188.380778592774 all mi 1 9.12E-05 1.19703675 rs2096148 191.081550805718 region-1 albu 1 9.35E-05 1.405085043 rs11810706 191.766940859739 all complications 1 4.35E-05 1.301939058 rs11810706 191.766940859739 all albu 1 7.39E-05 1.319114955 rs11810706 191.766940859739 peal albu 1 1.10E-04 1.319114955 rs11810706 191.766940859739 peal complications 1 3.32E-04 1.301939058 rs2481628 191.780915523017 all albu 1 2.38E-05 1.346677283 rs2481628 191.780915523017 peal albu 1 2.55E-05 1.346677283 rs2481628 191.780915523017 all complications 1 4.19E-04 1.282766454 rs2502845 191.783768123917 all albu 1 7.96E-05 1.320666787 rs2502845 191.783768123917 peal albu 1 8.45E-05 1.320666787 rs704829 191.791380002642 all albu 1 2.71 E-05 1.343773503 rs704829 191.791380002642 peal albu 1 2.89E-05 1.343773503 rs791743 191.79192208414 all albu 1 2.27E-05 1.348024433 rs791743 191.79192208414 peal albu 1 2.45E-05 1.348024433 rs7535769 191.801207495317 all albu 1 5.07E-06 1.387755102 rs7535769 191.801207495317 peal albu 1 6.02E-06 1.387755102 rs7535769 191.801207495317 all complications 1 6.63E-05 1.344667524 rs7535769 191.801207495317 peal complications 1 7.19E-05 1.344667524 rs191606 191.806351667483 all albu 1 3.66E-06 1.393353058 rs191606 191.806351667483 peal albu 1 4.55E-06 1.393353058 rs191606 191.806351667483 all complications 1 5.72E-05 1.347140579 rs191606 191.806351667483 peal complications 1 6.45E-05 1.347140579 rs3766623 194.171651961565 region-1 complications 1 4.70E-05 0.648906015 rs12403445 194.830368509238 peal stroke 1 3.57E-04 0.603234548 rs13375160 197.553967822085 region-1 albu 1 2.82E-05 0.70464695 rs13375160 197.553967822085 all albu 1 1.19E-04 0.731631614 rs6703571 200.423928547739 all complications 1 4.85E-05 1.361137154 rs6703571 200.423928547739 peal complications 1 7.35E-05 1.361137154 rs1501501 204.965895146666 region-1 albu 1 1.20E-05 0.602118388 rs10920754 204.970852826454 region-1 albu 1 7.99E-05 0.624662309 rs6428058 205.375483025664 region-3 mi 1 3.41 E-05 2.215813118 rs6428058 205.375483025664 all mi 1 1.24E-04 1.513290049 rs6428058 205.375483025664 peal mi 1 1.39E-04 1.513290049 rs658232 205.381437644175 region-3 mi 1 5.27E-05 2.122911827 rs658232 205.381437644175 all mi 1 4.98E-04 1.436447078 rs633095 205.388161084677 region-3 mi 1 7.01 E-05 2.120383037

Paαe 2 Table 1.xls

rs10801047 205.419083193297 all mi 1 9.51 E-06 1.745855806 rs10801047 205.419083193297 peal mi 1 1.74E-05 1.745855806 rs10801047 205.419083193297 region-3 mi 1 5.26E-05 2.560662853 rs1933711 206.575821317566 all albu 1 9.79E-05 0.816583188 rs6428134 206.668690623568 all albu 1 8.51E-05 1.176970218 rs10754026 206.672052749227 all albu 1 4.81 E-05 0.836149611 rs10921253 206.674677626693 all albu 1 7.91E-05 1.175844711 rs1933701 206.677121045239 all albu 1 9.96E-05 1.177528133 rs10737615 206.681493178096 all albu 1 7.13E-05 1.182942323 rs1418720 206.682777085553 all albu 1 9.61E-05 1.178974956 rs12143838 206.684301796985 all albu 1 7.91 E-05 1.180294993 rs1342810 206.688910168815 all albu 1 5.92E-05 1.18419578 rs1342803 206.689932729776 all albu 1 6.14E-05 1.182963481 rs10921262 206.697488953125 all albu 1 7.50E-05 1.180727075 rs17601491 207.403787557954 all mi 1 1.15E-05 0.426583431 rs17601491 207.403787557954 peal mi 1 2.43E-05 0.426583431 rs17601491 207.403787557954 region-3 complications 1 2.91 E-04 0.396143366 rs6663410 209.715359110275 region-3 complications 1 5.87E-05 2.017443071 rs7547363 212.432905865583 all complications 1 3.58E-05 1.25892991 rs7547363 212.432905865583 region-1 complications 1 2.38E-04 1.277908457 rs947377 214.753298954064 peal mi 1 2.31 E-04 1.701413154 rs17459837 214.753663563413 peal mi 1 2.35E-04 1.701053532 rs6427900 214.754661833991 peal mi 1 2.59E-04 1.446631709 rs2232847 216.624026971199 region-1 mi 1 7.77E-05 1.38674812 rs1418444 216.648524634912 region-1 mi 1 6.93E-05 1.399263873 rs11119385 221.664519061107 region-3 mi 1 5.32E-05 0.570379727 rs2012296 222.147420163734 all mi 1 7.20E-06 0.329959692 rs2012296 222.147420163734 peal mi 1 2.88E-05 0.329959692 rs2590681 224.319671675283 region-1 stroke 1 2.21E-05 1.50148884 rs11119552 229.712542231593 peal albu 1 3.93E-04 1.312848055 rs1770221 229.870739070077 peal complications 1 3.55E-04 1.354541584 rs11120230 232.375391784457 region-3 mi 1 1.85E-05 0.238888889 rs1528858 232.505312782992 all stroke 1 4.33E-05 1.270376416 rs17562778 234.217087709652 region-3 mi 1 7.87E-05 1.494545455 rs6658076 238.523870512638 region-3 mi 1 7.06E-05 1.749311741 rs6683441 238.929213100551 all complications 1 9.42E-05 1.212415991 rs1776046 239.475281454921 peal complications 1 3.05E-04 0.729149887 rs1694594 239.476072246517 peal complications 1 2.73E-04 0.728952098 rs2647442 239.478367574158 peal complications 1 3.11E-04 1.288058093 rs6663947 239.484829797772 peal complications 1 2.12E-04 1.291286999 rs 10779390 239.48647699804 peal complications 1 2.11 E-04 1.290615626 rs2027504 239.488046727825 peal complications 1 2.22E-04 1.289026596 rs2030078 239.488435773583 peal complications 1 2.31 E-04 1.289003996 rs1359150 243.175248658012 peal stroke 1 4.11 E-04 1.386248285 rs6672238 243.17749298628 peal stroke 1 4.97E-04 1.378414689 rs592228 243.543364501535 peal albu 1 2.99E-04 0.709568614 rs485056 243.545942517629 all albu 1 7.17E-05 0.690090469 rs485056 243.545942517629 peal albu 1 1.0OE-04 0.690090469 rs485056 243.545942517629 region-1 albu 1 2.22E-04 0.654943175 rs1637931 244.005218096793 peal albu 1 4.31 E-04 0.692047505 rs6676401 244.494019206887 all mi 1 5.47E-06 0.221179734

Page 3 Table 1.xls

rs6676401 244.494019206887 peal mi 3.34E-05 0.221179734 rs6676401 244.494019206887 region-1 mi 4.61 E-04 0.164644908 rs4279792 246.08958023099 peal stroke 2.61E-04 2.263401109 rs12403846 248.325419402142 peal albu 1.59E-04 0.75378542 rs6664939 248.720927401223 region-1 stroke 7.88E-05 1.62544484 rs1726673 255.995352561274 peal stroke 2.78E-04 0.709085631 rs2590577 256.006215812909 peal stroke 2.93E-04 0.709714286 rs627629 259.343678738226 all mi 4.64E-05 0.330922432 rs627629 259.343678738226 peal mi 1.12E-04 0.330922432 rs627629 259.343678738226 region-1 mi 2.49E-04 0.184862819 rs627629 259.343678738226 all stroke 4.59E-04 0.255171655 rs914947 272.939323335258 region-3 mi 4.35E-05 1.403773389 rs6692131 272.952281402644 region-3 mi 3.64E-05 1.391168831 rs6692131 272.952281402644 all mi 4.85E-04 1.271004376 rs10803196 275.952133125086 region-i stroke 2.84E-05 1.456147857 rs4658437 277.396344963376 region-3 complications 7.94E-06 0.49811828 rs4658437 277.396344963376 all complications 3.38E-04 0.773414365 rs4658437 277.396344963376 peal complications 3.52E-04 0.773414365 rs4658439 277.396574887442 region-3 complications 2.85E-06 2.047164179 rs4658439 277.396574887442 all complications 1.33E-05 0.744939067 rs4658439 277.396574887442 peal complications 1.42E-05 0.744939067 rs10754555 286.075704248594 region-1 stroke 9.35E-05 0.600588131 rs6587388 288.007248212357 region-3 stroke 6.42E-05 1.41468077 rs4661292 32.5311344992465 region-3 stroke 6.82E-05 1.214011299 rs4920424 41.6607127387873 all mi 1.95E-07 0.033781455 rs4920424 41.6607127387873 region-3 complications 3.71 E-05 0.22272216 rs4920424 41.6607127387873 region-1 mi 2.07E-04 0 rs4920424 41.6607127387873 all stroke 2.84E-04 0.065195712 rs2743208 43.6938693331805 all stroke 7.45E-05 1.271573964 rs17449243 46.9671947597037 region-1 stroke 2.21 E-05 1.031644895 rs17449243 46.9671947597037 all stroke 1.38E-04 1.161016949 rs11247842 54.8551425138048 region-1 mi 7.64E-05 1.453785484 rs4659401 54.8552003674079 region-1 mi 6.52E-05 1.457768229 rs535056 67.3030621476223 region-3 complications 8.99E-05 1.790436006 rs7539261 70.3645187314513 all stroke 8.49E-05 0.666977322 rs7539261 70.3645187314513 peal stroke 1.23E-04 0.666977322 rs272531 73.2324253701098 region-1 stroke 4.47E-05 0.922437313 rs11211590 74.9396033711077 all complications 4.73E-05 1.481307846 rs473806 79.3703929104729 region-3 mi 5.95E-05 3.689606075 rs478225 79.3710768192115 region-3 mi 5.41 E-05 3.714285714 rs10430114 79.6749634349868 peal albu 1.48E-04 0.704660248 rs17362438 82.7811188404582 peal complications 3.16E-04 1.488775576 rs17362459 82.7811580226607 peal complications 3.62E-04 1.483317524 rs17362494 82.7848348113964 peal complications 4.01 E-04 1.479323032 rs9436540 82.893070459867 peal mi 2.27E-04 1.441296482 rs3909441 89.8019527315127 all mi 1.06E-07 0.087195298 rs3909441 89.8019527315127 peal mi 2.66E-05 0.087195298 rs3909441 89.8019527315127 region-1 mi 3.67E-05 0 rs3909441 89.8019527315127 all stroke 4.84E-05 0.05473584 rs12142580 9.06158309215604 peal mi 1.70E-04 1.437085437 rs12142584 9.06165999831754 peal mi 1.70E-04 1.437085437

Page 4 Table 1.xls

rs12038994 9.19291033222694 region-1 mi 1 5.35E-05 1.18559377 rs16839198 9.19320371499117 region-1 mi 1 5.35E-05 1.179247991 rs13375764 9.19674139841996 region-1 mi 1 6.28E-05 1.191495081 rs10489135 9.20262044720985 region-1 mi 1 5.41 E-05 1.190697 rs2069112 90.3495952231632 all mi 1 4.44E-07 0.456224903 rs2069112 90.3495952231632 peal mi 1 1.12E-06 0.456224903 rs2069112 90.3495952231632 region-3 mi 1 6.71 E-05 0.3416122 rs11207744 93.644562649658 peal complications 1 3.72E-04 0.606106346 rs2182867 95.6570658050979 all complications 1 4.77E-05 0.533801036 rs2182867 95.6570658050979 peal complications 1 6.19E-05 0.533801036 rs6677463 95.8881598749644 region-3 stroke 1 7.28E-05 1.851160862 rs589465 97.0785968797677 region-3 mi 1 9.84E-05 0.63062378 rs2685263 1.39811765676322 peal stroke 2 1.84E-04 1.41428125 rs6547260 101.791914350287 peal complications 2 3.39E-04 1.473792911 rs1348557 102.743272607102 peal mi 2 5.00E-04 0.670792172 rs7568711 103.030306895771 region-1 stroke 2 3.12E-05 1.868167382 rs7568711 103.030306895771 all stroke 2 4.98E-04 1.528334843 rs17019785 103.102632582574 region-1 stroke 2 5.33E-05 1.839622642 rs17659181 103.656963572339 region-1 albu 2 8.71 E-05 0.638499333 rs12474795 105.880931308675 all stroke 2 7.97E-05 1.412280702 rs13431095 105.905493388889 all stroke 2 4.45E-05 1.410313599 rs1584308 105.908091125787 all stroke 2 4.45E-05 1.410313599 rs17024129 112.17244072521 region-1 stroke 2 1.41 E-05 4.112819796 rs17025554 113.181792287873 all albu 2 3.23E-06 0.671211309 rs17025554 113.181792287873 peal albu 2 2.84E-05 0.671211309 rs17025554 113.181792287873 region-1 albu 2 8.91 E-05 0.657321991 rs1401209 116.280735295902 peal mi 2 2.63E-04 1.43187072 rs7563316 116.282940073615 peal mi 2 2.06E-04 1.447894919 rs831969 118.880255731482 all complications 2 5.46E-05 0.820950357 rs17776629 127.739731393719 all stroke 2 8.69E-05 1.378276238 rs563697 127.758621927145 all stroke 2 3.08E-05 1.426862857 rs563697 127.758621927145 peal stroke 2 2.17E-04 1.426862857 rs2713249 129.940023506996 region-3 complications 2 4.42E-05 0.418010026 rs1453688 130.55874214611 all mi 2 6.19E-07 0.094905979 rs1453688 130.55874214611 peal mi 2 5.99E-05 0.094905979 rs1453688 130.55874214611 region-1 mi 2 9.85E-05 0 rs1453688 130.55874214611 all stroke 2 4.16E-04 0.120823621 rs2052815 132.504943238939 peal mi 2 3.77E-04 1.365185322 rs3980634 132.505400875317 peal mi 2 3.83E-04 1.364797618 rs4429419 134.00099618131 region-3 albu 2 2.47E-05 1.625417838 rs6744496 134.219042759774 peal mi 2 3.00E-04 0.754141052 rs2290482 143.764344274371 region-3 mi 2 1.23E-05 0.162962963 rs2290482 143.764344274371 all mi 2 2.22E-05 0.317986933 rs2290482 143.764344274371 peal mi 2 9.61 E-05 0.317986933 rs2290482 143.764344274371 region-3 stroke 2 3.47E-04 0.155451759 rs487311 146.191183842879 region-3 stroke 2 1.25E-05 1.680273586 rs487311 146.191183842879 all stroke 2 9.75E-05 1.222623821 rs4461205 148.154287196051 region-3 albu 2 5.39E-05 0.147925033 rs17801458 148.248391635537 region-3 albu 2 2.09E-05 0.284923928 rs10490076 152.932305300955 all complications 2 6.25E-05 0.705075226 rs10490076 152.932305300955 peal complications 2 6.61 E-05 0.705075226

Page 5 Table 1.xls

rs17745212 152.934362423902 peal complications 3.30E-04 0.728320774 rs16830446 154.439886829839 region-3 complications 9.14E-05 0.340105648 rs4449085 156.81009203095 region-3 complications 7.70E-05 1.533947066 rs1519635 156.874814575442 region-3 complications 1 J7E-05 1.590119904 rs7557853 159.083509873554 all stroke 2.51 E-05 1.207398066 rs7557853 159.083509873554 region-1 stroke 6.05E-05 1.231734765 rs2528632 162.646810681501 all mi 5.23E-05 1.226788432 rs2528632 162.646810681501 region-1 mi 2.79E-04 1.171579169 rs11890075 163.874484179949 region-1 albu 3.89E-05 0.469158942 rs7557611 164.298285947542 all complications 2.79E-05 1.357456695 rs7557611 164.298285947542 peal complications 3.20E-05 1.357456695 rs7557611 164.298285947542 all albu 5.36E-05 1.331088083 rs7557611 164.298285947542 peal albu 6.08E-05 1.331088083 rs7557611 164.298285947542 region-1 albu 2.67E-04 1.375170051 rs4368343 164.382569256035 peal complications 4.33E-04 1.285938749 rs7581204 164.479511301393 all complications 5.54E-06 1.30980162 rs7581204 164.479511301393 peal complications 7.58E-05 1.30980162 rs565736 164.495533268148 all complications 2 4.87E-05 1.316590381 rs565736 164.495533268148 peal complications 5.16E-05 1.316590381 rs558692 164.500782905042 all complications 4.83E-05 1.317441944 rs558692 164.500782905042 peal complications 5.11 E-05 1.317441944 rs6720147 164.517725766795 all complications 2 1.08E-05 1.298894672 rs6720147 164.517725766795 peal complications 2 1.27E-04 1.298894672 rs9967822 164.523790110213 all complications 2 1.08E-05 1.301117935 rs9967822 164.523790110213 peal complications 2 1.16E-04 1.301117935 rs6432655 164.535205817298 all complications 2 1.03E-05 1.305856836 rs6432655 164.535205817298 peal complications 2 9.25E-05 1.305856836 rs4664386 164.570483591384 all complications 2 8.27E-06 1.314705376 rs4664386 164.570483591384 peal complications 2 5.78E-05 1.314705376 rs10497221 164.57403778206 all complications 2 2.24E-05 1.299309795 rs10497221 164.57403778206 peal complications 2 1.14E-04 1.299309795 rs1516093 164.581483467975 all complications 5.05E-05 1.315805066 rs1516093 164.581483467975 peal complications 5.34E-05 1.315805066 rs10497220 164.588726592685 peal complications 1.68E-04 1.294186794 rs16845844 165.03452989814 region-1 stroke 5.90E-06 1.073825503 rs16845844 165.03452989814 all stroke 8.62E-05 1.331815595 rs7565023 165.957390721561 all mi 3.72E-07 0.13599329 rs7565023 165.957390721561 peal mi 1.46E-05 0.13599329 rs7565023 165.957390721561 region-1 mi 1.10E-04 0.058978583 rs9287822 166.167706363144 region-3 stroke 4.47E-05 0.276048493 rs10202400 166.173912588641 region-3 stroke 8.63E-05 0.278719653 rs9807929 166.176362062255 region-3 stroke 7.03E-05 0.283225318 rs11684348 166.178940032846 region-3 stroke 9.92E-05 0.28109589 rs4091356 166.178969480069 region-3 stroke 6.74E-05 0.298523761 rs6736615 166.202174784747 region-3 stroke 8.07E-05 0.301704967 rs10153806 166.212456327546 region-3 stroke 8.63E-05 0.278719653 rs7579000 168.007814310628 region-1 mi 6.12E-05 0.91398124 rs10205352 17.1910103899304 region-3 stroke 7.48E-05 1.78283143 rs10166160 170.171270655154 peal albu 1.51E-04 1.4474573 rs4387746 170.172061857785 peal albu 2.25E-04 1.43136653 rs3769177 176.851403861254 region-3 mi 7.68E-05 1.447014925

Page 6 Table1.xls

rs4972535 176.874452934254 regιon-3 mi 2 1.79E-05 1.462776915 rs2630728 18.9208144359998 all mi 2 4.10E-05 1.365967951 rs16863394 181.698977072339 peal mi 2 3.79E-04 0.547592882 rs6720074 182.553537641218 all complications 2 3.16E-05 0.78101715 rs10186021 182.556577248708 all complications 2 3.10E-05 0.784900869 rs7355631 182.557042129854 all complications 2 7.15E-05 0.796409053 rs1112587 182.561604054288 all complications 2 3.16E-05 0.78838478 rs1402108 182.561935320905 all complications 2 2.21 E-05 0.787427075 rs1402108 182.561935320905 region-1 complications 2 3.56E-04 0.802467234 rs4893998 182.561973692203 all complications 2 3.16E-05 0.785608763 rs2037382 182.562920742744 all complications 2 1.36E-05 0.781958817 rs6738614 182.806290446427 region-1 stroke 2 9.37E-05 0.244845531 rs10189134 182.81317432424 region-1 stroke 2 9.25E-05 0.244614979 rs16866776 184.374120356446 region-3 stroke 2 8.22E-06 0.347462354 rs7567280 186.045261779963 all complications 2 3.36E-06 0.735196102 rs7567280 186.045261779963 peal complications 2 5.64E-06 0.735196102 rs7567280 186.045261779963 region-1 complications 2 5.51 E-05 0.737368494 rs10184559 187.057958642181 all stroke 2 2.57E-05 1.373367027 rs10189482 187.066472983289 all stroke 2 1.58E-05 1.376670061 rs10197403 187.073912934104 all stroke 2 4.50E-06 1.354571525 rs10197403 187.073912934104 region-1 stroke 2 5.09E-05 1.414803587 rs4552153 187.078719013081 all stroke 2 4.56E-06 1.353576248 rs4552153 187.078719013081 region-1 stroke 2 5.15E-05 1.413351017 rs4442964 187.079655671384 all stroke 2 4.50E-06 1.354571525 rs4442964 187.079655671384 region-1 stroke 2 5.09E-05 1.414803587 rs12693436 187.08273383996 all stroke 2 4.56E-06 1.35048153 rs12693436 187.08273383996 region-1 stroke 2 5.09E-05 1.414803587 rs9973427 187.262712793469 all mi 2 1.85E-07 0.062635087 rs9973427 187.262712793469 peal mi 2 1.17E-04 0.062635087 rs9973427 187.262712793469 all stroke 2 1.35E-04 0.059678276 rs9973427 187.262712793469 region-3 mi 2 2.29E-04 0.063660991 rs9973427 187.262712793469 region-1 mi 2 4.27E-04 0.068094454 rs1520472 187.695175485013 all mi 2 1.11 E-05 0.33689234 rs1520472 187.695175485013 peal mi 2 3.67E-05 0.33689234 rs12693546 188.958286064618 all albu 2 4.92E-05 1.167262469 rs7577717 192.9759447716 all mi 2 1.38E-07 0.033016026 rs7577717 192.9759447716 region-1 mi 2 2.19E-04 0 rs7577717 192.9759447716 all stroke 2 2.39E-04 0.063821122 rs7577717 192.9759447716 region-3 mi 2 2.81 E-04 0.06521522 rs6761003 193.987990520512 peal stroke 2 3.22E-04 2.245245529 rs10199478 194.048941334414 all stroke 2 1.95E-05 2.409990619 rs10199478 194.048941334414 peal stroke 2 4.93E-05 2.409990619 rs13386098 194.077052354114 peal stroke 2 4.70E-04 2.085730994 rs12987074 196.028320028393 region-1 stroke 2 7.00E-05 1.503460332 rs6720902 206.536714646296 peal mi 2 3.57E-04 0.759861455 rs2577302 212.369005056866 region-3 complications 2 5.97E-05 0.302387268 rs16854563 212.688332449961 peal albu 2 1.76E-04 1.523448958 rs1250072 212.7402621316 region-3 mi 2 9.34E-06 0.621597004 rs744564 215.602959770847 region-1 complications 2 2.71 E-05 0.515236483 rs744564 215.602959770847 all complications 2 4.96E-05 0.59400771 rs744564 215.602959770847 peal complications 2 1.04E-04 0.59400771

Paαe 7 Table LxIs

rs744564 215.602959770847 region- 1 mi 2 1.86E-04 0.415134117 rs2396328 226.911943382518 region-1 albu 2 3.17E-06 0.688958452 rs2396328 226.911943382518 all albu 2 4.86E-06 0.733143679 rs2396328 226.911943382518 peal albu 2 5.30E-06 0.733143679 rs2396328 226.911943382518 all complications 2 2.58E-05 0.750847397 rs2396328 226.911943382518 peal complications 2 2.76E-05 0.750847397 rs2396328 226.911943382518 region-1 complications 2 1.60E-04 0.742321404 rs4586627 226.93025563861 region-1 albu 2 2.33E-06 0.682441014 rs4586627 226.93025563861 all albu 2 5.61 E-05 0.758952216 rs4586627 226.93025563861 peal albu 2 5.92E-05 0.758952216 rs4586627 226.93025563861 all complications 2 8.46E-05 0.764233319 rs4586627 226.93025563861 peal complications 2 8.87E-05 0.764233319 rs4586627 226.93025563861 region-1 complications 2 8.87E-05 0.73116166 rs4586627 226.93025563861 region-3 complications 2 2.55E-04 0.882150917 rs16825771 226.930523192579 region-1 albu 2 1.90E-06 0.676801647 rs16825771 226.930523192579 all albu 2 1.84E-05 0.745430645 rs16825771 226.930523192579 peal albu 2 1.98E-05 0.745430645 rs16825771 226.930523192579 all complications 2 3.48E-05 0.752881047 rs16825771 226.930523192579 peal complications 2 3.70E-05 0.752881047 rs16825771 226.930523192579 region-1 complications 2 1.08E-04 0.734321309 rs10172617 231.836491705787 all mi 2 4.91 E-05 1.302374249 rs10189426 243.333481469538 region-3 mi 2 9.16E-05 4.437908497 rs2646261 252.451717820453 peal albu 2 1.17E-04 1.507068063 rs6431547 253.112551667033 all complications 2 2.88E-05 0.727735067 rs6431547 253.112551667033 peal complications 2 3.46E-05 0.727735067 rs7558224 256.942476396379 all stroke 2 2.66E-05 1.36590578 rs1437728 259.174427297203 region-3 stroke 2 1.17E-05 1.925735013 rs12472311 259.20957662006 region-3 stroke 2 4.25E-05 2.088440406 rs12472418 273.384851517017 region-3 albu 2 4.88E-05 0.467325037 rs2140525 33.130416301259 peal mi 2 3.35E-04 1.551683262 rs12622278 33.7824077833408 all mi 2 4.56E-06 0.230634334 rs12622278 33.7824077833408 all stroke 2 3.20E-05 0.092795837 rs12622278 33.7824077833408 peal mi 2 3.92E-05 0.230634334 rs12622278 33.7824077833408 region-3 stroke 2 3.95E-04 0 rs735447 34.9633111277583 all stroke 2 5.23E-05 1.268980839 rs735447 34.9633111277583 region-1 stroke 2 1.56E-04 1.339196979 rs2341504 37.5795697894671 peal mi 2 2.38E-04 0.749574864 rs16984512 38.4871265330008 region-1 stroke 2 5.99E-05 3.487778263 rs1509379 43.2664246990916 region-3 stroke 2 3.51 E-05 2.753141168 rs3820821 46.6049039586263 all mi 2 6.44E-06 2.048078511 rs3820821 46.6049039586263 peal mi 2 9.43E-06 2.048078511 rs3820821 46.6049039586263 region-1 mi 2 2.70E-04 2.086668165 rs17006815 47.4017021372529 all albu 2 4.64E-05 1.689573777 rs17006815 47.4017021372529 peal albu 2 8.06E-05 1.689573777 rs7559372 47.9636460307791 all mi 2 8.57E-06 0.205139903 rs7559372 47.9636460307791 peal mi 2 6.08E-05 0.205139903 rs7559372 47.9636460307791 all complications 2 3.03E-04 0.487508059 rs7559372 47.9636460307791 peal complications 2 4.46E-04 0.487508059 rs7421353 48.0629134730808 region-1 complications 2 7.55E-05 0.732486543 rs1213578 5.20844354433002 peal mi 2 4.82E-04 0.757477167 rs7607204 52.0021339584778 all stroke 2 8.02E-05 1.543250213

Page 8 Table 1.xls

rs7607204 52.0021339584778 peal stroke 2 9.45E-05 1.543250213 rs10495829 53.5136077138756 all albu 2 1.78E-05 2.265507283 rs10495829 53.5136077138756 peal albu 2 2.93E-05 2.265507283 rs10495829 53.5136077138756 region-1 albu 2 2.51 E-04 2.689651618 rs10495829 53.5136077138756 all complications 2 4.91 E-04 2.178354204 rs4670110 54.0887447631275 peal complications 2 2.64E-04 1.351591282 rs3770887 56.2104454194737 all mi 2 6.67E-05 1.35166963 rs7422754 56.6733690562561 peal mi 2 2.82E-04 1.313563755 rs17022224 59.2393345069855 all mi 2 3.03E-08 0.119418484 rs17022224 59.2393345069855 region-3 mi 2 4.32E-06 0.129583333 rs17022224 59.2393345069855 peal mi 2 4.54E-06 0.119418484 rs17022224 59.2393345069855 region-1 mi 2 1.32E-04 0.05903849 rs1560260 61.5713859597375 all mi 2 8.00E-06 1.287941044 rs1560260 61.5713859597375 region-1 mi 2 2.93E-04 1.302140468 rs1560258 61.5714966816606 all mi 2 8.00E-06 1.29511569 rs1560258 61.5714966816606 region-1 mi 2 2.93E-04 1.307342217 rs7568164 61.5736703598555 all mi 2 6.96E-05 1.271070306 rs7568164 61.5736703598555 region-1 mi 2 3.54E-04 1.295760831 rs4952521 61.965783387596 peal complications 2 2.68E-04 1.286879742 rs614281 69.3206482761171 peal complications 2 2.76E-04 0.767700635 rs896932 7.40978242027033 region-1 complications 2 4.35E-05 0.471381347 rs896932 7.40978242027033 all complications 2 3.18E-04 0.576376554 rs896930 7.41030549587217 region-1 complications 2 4.20E-05 0.470716962 rs896930 7.41030549587217 all complications 2 3.11 E-04 0.575865129 rs896930 7.41030549587217 peal complications 2 4.98E-04 0.575865129 rs11563175 72.985520809 peal mi 2 2.34E-04 2.354621849 rs6545316 73.6094773462112 peal mi 2 4.30E-04 0.769664552 rs1011275 75.3124270603325 peal albu 2 3.77E-04 0.764647853 rs10168390 77.1783193920234 all mi 2 1.97E-05 1.445248009 rs10168390 77.1783193920234 peal mi 2 3.80E-04 1.445248009 rs11125644 77.271312459132 all mi 2 1.97E-05 0.174343193 rs11125644 77.271312459132 peal mi 2 1.55E-04 0.174343193 rs11125644 77.271312459132 region-1 mi 2 3.87E-04 0.068338861 rs11688740 80.0259360585699 all albu 2 5.88E-05 1.369610969 rs11688740 80.0259360585699 peal albu 2 7.62E-05 1.369610969 rs11688740 80.0259360585699 all complications 2 2.86E-04 1.345348683 rs11688740 80.0259360585699 peal complications 2 3.29E-04 1.345348683 rs6731529 85.8912411798728 all mi 2 9.89E-06 1.249521229 rs6731529 85.8912411798728 region-3 mi 2 2.01 E-04 1.643732149 rs2683690 85.9475610179294 peal complications 2 1.91 E-04 1.313086025 rs10208883 86.3286809738902 peal mi 2 4.31 E-04 0.736393828 rs2278791 88.0984714743629 all stroke 2 7.98E-05 1.449184287 rs2278791 88.0984714743629 peal stroke 2 1 -07E-04 1.449184287 rs7606793 88.098625108004 peal stroke 2 1.95E-04 1.433054424 rs6713 88.5469011245058 peal complications 2 3.82E-04 0.771665353 rs6747506 90.2471565812444 region-1 stroke 2 1.73E-05 2.24742268 rs6747506 90.2471565812444 all stroke 2 4.40E-04 1.739861281 rs1487025 97.872280676017 all mi 2 7.62E-05 0.467603399 rs1487025 97.872280676017 peal mi 2 1.10E-04 0.467603399 rs1487025 97.872280676017 all complications 2 2.84E-04 0.603445297 rs1487025 97.872280676017 peal complications 2 3.29E-04 0.603445297

Paαe 9 Table 1.xls

rs4677360 103.994336553497 all stroke 3 8.87E-05 1.373270236 rs9850420 107.419847013348 all mi 3 5.49E-08 0.058540446 rs9850420 107.419847013348 region-1 mi 3 5.67E-05 0 rs9850420 107.419847013348 peal mi 3 6.82E-05 0.058540446 rs9850420 107.419847013348 all stroke 3 8.03E-05 0.056637168 rs9850420 107.419847013348 region-3 mi 3 1.64E-04 0.061262783 rs9813365 107.994956312009 region-3 mi 3 6.84E-05 0.579000505 rs12631421 113.813775377805 all complications 3 4.39E-05 1.197652891 rs7631170 113.814341243144 all complications 3 1.90E-05 1.224190025 rs16861123 113.816794980093 all complications 3 2.10E-05 1.222895277 rs9846098 113.81761126761 all complications 3 8.74E-05 1.199928639 rs6785972 113.818549850282 all complications 3 1.36E-05 1.240633785 rs6414256 113.820738280732 all complications 3 7.74E-05 1.215494756 rs6438092 113.822770556372 all complications 3 8.07E-05 1.212216395 rs9833997 113.823067111242 all complications 3 1.81 E-05 1.223937822 rs6438104 113.823752573408 all complications 3 3.64E-05 1.213000756 rs6414257 113.823843097936 all complications 3 8.72E-05 1.218217164 rs13067150 113.825883033344 all complications 3 5.31 E-05 1.216868951 rs10934261 113.829533086739 all complications 3 7.50E-05 1.19674271 rs1433242 113.831096723864 all complications 3 2.24E-05 1.237958271 rs6808691 113.833732467339 all complications 3 6.20E-05 1.214191292 rs513994 117.099511283371 all complications 3 7.31 E-05 0.752607846 rs5009801 117.150084924902 region-1 albu 3 5.91 E-05 1.394832945 rs9877228 117.160548795258 region-1 albu 3 4.25E-05 1.404031591 rs9877228 117.160548795258 region-1 complications 3 3.38E-04 1.337851406 rs9875156 117.162821619314 region-1 albu 3 5.91 E-05 1.394832945 rs9857723 117.197686702558 region-1 albu 3 4.61 E-05 1.402517452 rs1520653 117.201475687301 region-1 albu 3 5.91 E-05 1.394832945 rs12497154 117.203188334855 region-1 albu 3 5.12E-05 1.401029673 rs2317750 117.209923677966 region-1 albu 3 5.91 E-05 1.394832945 rs9822356 117.223356578251 region-1 albu 3 8.60E-05 1.385246168 rs12496159 117.262374335873 region-1 albu 3 8.15E-05 1.386158449 rs2317703 117.266385312991 region-1 albu 3 5.91 E-05 1.394832945 rs3846087 117.294344071763 region-1 albu 3 5.91 E-05 1.394832945 rs2317704 117.312119520755 region-1 albu 3 5.74E-05 1.395738747 rs16843947 117.319634198798 region-1 albu 3 5.57E-05 1.396612543 rs17345528 117.373073903583 peal albu 3 4.79E-04 1.310428603 rs6791614 117.782756363505 all stroke 3 2.80E-05 1.121409863 rs6791614 117.782756363505 region-1 stroke 3 2.78E-04 1.048680518 rs7628402 118.059535892375 all mi 3 4.42E-07 0.066197047 rs7628402 118.059535892375 region-3 mi 3 1.04E-04 0 rs7628402 118.059535892375 peal mi 3 1.86E-04 0.066197047 rs7628402 118.059535892375 all stroke 3 2.19E-04 0.063147936 rs17023520 12.1104454496626 region-3 complications 3 7.93E-05 0.639532108 rs17606712 12.5878497998675 all complications 3 9.52E-06 0.392053544 rs17606712 12.5878497998675 peal complications 3 2.42E-05 0.392053544 rs17026903 12.8398107223924 region-3 stroke 3 7.60E-05 2.021021021 rs1879511 127.182908361283 region-1 albu 3 6.15E-05 0.646149664 rs10934167 127.193452796634 region-1 albu 3 6.15E-05 0.646149664 rs2895395 127.20015817158 region-1 albu 3 6.28E-05 0.642087332 rs4355254 127.200207660736 region-1 albu 3 6.34E-05 0.643885854

Page 10 Table 1.xls

rs9824256 128.637737014395 all complications 3 4.24E-05 0.91715528 rs9824256 128.637737014395 region-1 complications 3 3.89E-04 0.978531972 rs9288989 128.638038817115 all complications 3 4.11 E-05 0.921399636 rs9288989 128.638038817115 region-1 complications 3 3.26E-04 0.985212482 rs4682516 128.639471568737 all complications 3 2.59E-05 0.914609125 rs4682516 128.639471568737 region-1 complications 3 3.03E-04 0.973365617 rs7611310 130.007216508888 peal albu 3 3.29E-04 1.281927875 rs10511345 130.008048082817 all albu 3 9.38E-06 1.326179861 rs10511345 130.008048082817 region-1 albu 3 6.09E-05 1.399804048 rs10511345 130.008048082817 peal albu 3 7.70E-05 1.326179861 rs10511345 130.008048082817 all complications 3 1.59E-04 1.255139971 rs7653303 130.013033440033 peal albu 3 2.69E-04 1.367149441 rs1135750 137.577130271653 region-1 stroke 3 3.63E-05 1.428486069 rs6802715 137.604975204846 region-1 stroke 3 3.28E-05 1.442678908 rs2331964 137.607267521094 region-1 stroke 3 2.62E-05 1.452042943 rs1920321 137.615292305265 region-1 stroke 3 3.72E-05 1.441343406 rs17753899 142.431133048368 peal complications 3 1.65E-04 0.647679325 rs2358766 142.455016683119 peal complications 3 3.22E-04 0.781113448 rs1549876 142.941754609148 region-1 complications 3 8.80E-05 0.729067693 rs6770337 142.948338398221 region-1 complications 3 7.66E-05 0.726959212 rs1030656 142.980141182543 region-1 complications 3 4.82E-05 0.71839348 rs2075402 142.987058649129 region-1 complications 3 4.65E-05 0.718098736 rs2811489 143.346824801078 region-3 complications 3 4.98E-05 1.514623786 rs6439200 144.13371418904 peal albu 3 4.40E-04 0.638948557 rs809213 144.194157230398 peal albu 3 3.65E-04 0.64083558 rs4560339 149.495009447775 all mi 3 1.45E-05 2.516449425 rs4560339 149.495009447775 region-1 mi 3 1.70E-05 3.190843758 rs4560339 149.495009447775 peal mi 3 2.84E-05 2.516449425 rs1526939 150.011929302398 peal complications 3 4.96E-04 0.743437483 rs7615720 150.012049322111 peal complications 3 4.37E-04 0.741615332 rs10804636 150.014580752394 peal complications 3 2.62E-04 0.731615045 rs4678297 151.039400094702 peal complications 3 4.10E-04 0.773189707 rs811811 151.609719277563 all stroke 3 5.23E-05 0.674904943 rs811811 151.609719277563 peal stroke 3 2.37E-04 0.674904943 rs16849578 152.617192582357 peal complications 3 3.52E-04 0.684188235 rs11707973 152.644548409536 all albu 3 7.62E-05 0.812174537 rs17347351 152.840605483329 region-1 stroke 3 2.17E-05 1.930775468 rs6802753 153.282277156915 region-1 albu 3 1.90E-05 0.427408613 rs6802753 153.282277156915 region-1 complications 3 1.52E-04 0.526833631 rs6802753 153.282277156915 all complications 3 3.95E-04 0.594539474 rs13070811 159.425671888947 all stroke 3 1.13E-05 1.354793233 rs6440677 166.940852496973 region-3 stroke 3 1.70E-05 1.976447833 rs9680927 167.978120944217 peal complications 3 2.22E-04 0.529368419 rs17368784 169.679959570557 region-1 mi 3 5.35E-05 1.440458689 rs17437560 169.752358732938 all mi 3 5.08E-05 1.366051205 rs16822521 170.15894327767 all mi 3 2.46E-05 0.433891093 rs16822521 170.15894327767 peal mi 3 6.14E-05 0.433891093 rs2862824 170.222646708117 peal mi 3 4.79E-04 1.317701181 rs16852496 177.880469327057 region-3 stroke 3 3.06E-06 1.728784029 rs16852503 177.882833156257 region-3 stroke 3 5.84E-06 1.716594828 rs16855137 180.01763369755 region-1 albu 3 3.22E-05 0.677843668

Page 11 Table 1.xls

rs2730306 19.9658278609074 peal albu 3 2.53E-04 1.638153384 rs7624432 190.907765370402 all mi 3 3.76E-06 0.158713301 rs7624432 190.907765370402 peal mi 3 5.42E-05 0.158713301 rs7624432 190.907765370402 region-3 mi 3 7.48E-05 0.136274723 rs1420639 191.941206844021 peal stroke 3 4.64E-04 2.316058394 rs6444003 196.296801547209 all mi 3 1.31 E-06 0.071238717 rs6444003 196.296801547209 region-1 mi 3 1.69E-05 0 rs6444003 196.296801547209 all stroke 3 1.13E-04 0 rs6444003 196.296801547209 peal mi 3 2.28E-04 0.071238717 rs3773383 2.15814862492975 region-1 mi 3 8.40E-05 0.685714286 rs156168 21.1888077163179 region-1 mi 3 3.80E-05 0.630409319 rs4118375 210.141381280589 peal complications 3 2.98E-04 0.713835105 rs9290927 211.88581720742 region-1 stroke 3 4.79E-05 1.4 rs9290927 211.88581720742 all stroke 3 2.23E-04 1.324954949 rs6780822 215.855418276548 region-3 albu 3 3.57E-05 1.635178715 rs6780822 215.855418276548 region-3 complications 3 2.39E-04 1.753529649 rs1061860 215.855471776659 region-3 albu 3 3.10E-05 1.651471985 rs1061860 215.855471776659 region-3 complications 3 2.54E-04 1.762297297 rs9861931 217.275089016441 region-1 albu 3 3.55E-05 1.199181764 rs7373237 219.984609230782 all mi 3 3.87E-05 1.27861264 rs4916446 224.226198519028 peal stroke 3 4.85E-04 0.690067661 rs1602 224.323354760653 peal stroke 3 1.96E-04 0.674815525 rs161905 24.6247300752987 all complications 3 5.10E-05 1.255061984 rs161455 24.6250866670665 all complications 3 8.64E-05 1.242928863 rs414989 24.6646111023266 peal complications 3 2.79E-04 1.289699312 rs6803927 24.7103791650082 all complications 3 3.70E-05 0.754715623 rs6803927 24.7103791650082 peal complications 3 4.86E-05 0.754715623 rs6782967 24.710524746051 peal complications 3 3.12E-04 1.287043288 rs9815517 24.7259759654967 peal complications 3 1.62E-04 0.769639099 rs17050187 29.7794930269057 region-3 mi 3 6.00E-05 4.061004785 rs11708202 32.8094635256272 region-1 albu 3 1.17E-05 1.301161953 rs357121 37.5247403654583 all mi 3 7.84E-05 0.730011934 rs357121 37.5247403654583 peal mi 3 1.04E-04 0.730011934 rs17042372 41.6839002461736 peal albu 3 1.98E-04 1.493789778 rs7621243 42.0588014062359 peal albu 3 2.82E-04 0.677489821 rs12485415 42.394848397887 all albu 3 2.28E-05 2.072006208 rs12485415 42.394848397887 region-1 albu 3 3.19E-05 2.313781142 rs12485415 42.394848397887 peal albu 3 3.52E-05 2.072006208 rs17005998 42.6128066651208 all stroke 3 9.93E-05 2.886486486 rs17005998 42.6128066651208 peal stroke 3 2.23E-04 2.886486486 rs951678 42.6731372260012 peal stroke 3 2.60E-04 2.964542652 rs17006048 42.6784838526837 all stroke 3 7.02E-05 3.054591621 rs17006048 42.6784838526837 peal stroke 3 1.88E-04 3.054591621 rs17006048 42.6784838526837 region-3 stroke 3 4.51 E-04 3.389084507 rs7652049 42.7117199072742 all stroke 3 1.23E-05 3.45971223 rs7652049 42.7117199072742 peal stroke 3 5.41 E-05 3.45971223 rs7652049 42.7117199072742 region-3 stroke 3 1.39E-04 3.863179074 rs7640905 42.7983287907513 all stroke 3 3.01 E-05 3.247526978 rs7640905 42.7983287907513 peal stroke 3 1.04E-04 3.247526978 rs7640905 42.7983287907513 region-3 stroke 3 4.51 E-04 3.389084507 rs1356791 43.3979407094709 region-1 complications 3 9.48E-05 1.290768055

Page 12 Table 1.xls

rs9836392 43.3991563011196 region-1 complications 3 5.85E-05 1.305244224 rs939298 43.4872026913505 region-1 stroke 3 9.30E-05 0.934474957 rs17007502 43.7442100316608 peal complications 3 3.40E-04 1.576159214 rs4610242 43.7501406454621 all complications 3 2.11E-05 0.732861304 rs4610242 43.7501406454621 peal complications 3 2.62E-05 0.732861304 rs4610242 43.7501406454621 all mi 3 1.28E-04 0.724734758 rs4610242 43.7501406454621 peal mi 3 1.56E-04 0.724734758 rs4857989 44.2972943489672 region-3 complications 3 4.41 E-05 0.653542537 rs2335808 44.5259351888156 all mi 3 3.41 E-05 0.836690841 rs10510514 44.5280339486762 all mi 3 4.33E-05 0.842415325 rs7628779 48.5679938512631 peal mi 3 3.95E-04 0.385041644 rs17032728 5.64543878815937 region-1 albu 3 5.56E-05 2.63476586 rs9826565 51.2626629173613 all complications 3 8.22E-05 0.805674621 rs9826565 51.2626629173613 all albu 3 3.94E-04 0.841920809 rs9829625 51.3700213610277 peal stroke 3 4.41 E-04 2.179534928 rs2370919 51.4016183437826 all mi 3 5.21E-06 0.330582084 rs2370919 51.4016183437826 peal mi 3 1.42E-05 0.330582084 rs2370919 51.4016183437826 all stroke 3 7.03E-05 0.245087361 rs2370919 51.4016183437826 peal stroke 3 2.49E-04 0.245087361 rs2370919 51.4016183437826 region-3 stroke 3 2.77E-04 0.066848073 rs2053859 54.7175766771174 region-1 albu 3 2.68E-05 1.303429423 rs2053859 54.7175766771174 all albu 3 3.31 E-04 1.195975351 rs1485926 58.0257507585706 region-3 stroke 3 6.42E-05 1.490909091 rs4955377 58.0662844013229 region-3 stroke 3 9.79E-05 1.514113456 rs17027171 58.0679794080723 region-3 stroke 3 8.84E-05 1.53131929 rs13319491 58.068029585892 region-3 stroke 3 9.10E-05 1.483585859 rs10510647 58.0698480300778 region-3 stroke 3 9.79E-05 1.543783081 rs12630175 58.0800431594841 region-3 stroke 3 9.64E-05 1.532228018 rs2035558 58.0820894109714 region-3 stroke 3 9.79E-05 1.543783081 rs2035559 58.0821375816783 region-3 stroke 3 9.79E-05 1.543783081 rs4955385 58.0893411094742 region-3 stroke 3 1.98E-05 1.601652893 rs7626417 58.2643051454238 region-3 mi 3 4.26E-05 1.858518885 rs17027581 58.2876318102452 peal mi 3 4.39E-04 1.377385065 rs931567 58.290061420275 peal mi 3 3.52E-04 1.382330097 rs1464412 61.3891136981571 peal complications 3 1.87E-04 0.772725371 rs6787455 65.4915734305595 peal stroke 3 4.19E-04 1.446265697 rs4973924 65.7105824472007 region-3 mi 3 5.71 E-05 1.666383521 rs7630377 65.7191287713584 region-3 mi 3 9.98E-05 1.673728814 rs13072632 65.7636823372774 region-3 mi 3 9.78E-05 1.695232608 rs2278963 69.9097894064271 all complications 3 2.12E-05 0.754266358 rs2278963 69.9097894064271 peal complications 3 4.59E-05 0.754266358 rs11917361 69.9113431289672 all complications 3 1.95E-05 0.75080032 rs11917361 69.9113431289672 peal complications 3 3.77E-05 0.75080032 rs6442055 69.9153422644407 all complications 3 2.48E-05 0.755665211 rs6442055 69.9153422644407 peal complications 3 5.10E-05 0.755665211 rs6767907 69.9205059958852 all complications 3 2.48E-05 0.755665211 rs6767907 69.9205059958852 peal complications 3 5.10E-05 0.755665211 rs17410853 69.9405200657959 all complications 3 1.09E-05 0.784352905 rs1526591 71.7409225371831 all mi 3 3.87E-09 0.285651602 rs1526591 71.7409225371831 peal mi 3 2.88E-08 0.285651602 rs1526591 71.7409225371831 region-3 mi 3 2.53E-06 0.203544304

Page 13 Table1.xls

rs1526591 71.7409225371831 all albu 3 1.29E-05 1.805233075 rs1526591 71.7409225371831 peal albu 3 1.69E-05 1.805233075 rs1526591 71.7409225371831 region-1 mi 3 4.14E-05 0.317310924 rs1526591 71.7409225371831 all stroke 3 2.25E-04 0.393541811 rs1526591 71.7409225371831 peal stroke 3 3.68E-04 0.393541811 rs9851360 75.4773343890922 peal mi 3 4.59E-04 1.301123027 rs1546060 75.4778019890165 peal mi 3 2.36E-04 1.316923553 rs2363683 80.54272809913 all stroke 3 9.08E-05 1.7228125 rs2363683 80.54272809913 peal stroke 3 1.09E-04 1.7228125 rs17064029 80.6129131347219 all complications 3 6.76E-05 1.428630025 rs1390435 86.6931483775834 region-1 mi 3 6.94E-05 1.317293042 rs9872164 90.2040300564453 peal complications 3 2.57E-04 0.718013888 rs7653116 91.7297743504991 peal stroke 3 4.26E-04 1.387143157 rs1524966 92.5049452111628 region-1 stroke 3 7.88E-05 1.146374712 rs1552620 95.7934683645281 peal stroke 3 2.13E-04 0.641237907 rs1387859 95.801318984468 peal stroke 3 2.81 E-04 0.647024488 rs1490239 95.8014192379642 peal stroke 3 3.12E-04 0.649564505 rs17027538 104.814704857988 all mi 4 9.82E-06 0.282063695 rs17027538 104.814704857988 peal mi 4 4.15E-05 0.282063695 rs17027538 104.814704857988 all stroke 4 7.53E-05 0.168910649 rs17566763 105.086423779276 region-1 stroke 4 4.72E-05 1.460717503 rs4699668 105.102791035837 region-1 stroke 4 4.54E-05 1.582664611 rs13111631 109.271805412256 region-3 stroke 4 9.90E-06 1.53957529 rs4536931 109.392904525747 region-3 stroke 4 2.30E-05 2.753141168 rs4956126 112.434554771701 all complications 4 3.19E-05 1.233673188 rs4147477 113.191163705839 region-3 albu 4 9.28E-05 0.774738611 rs12641411 114.214549028687 all mi 4 2.85E-05 1.28908226 rs12641411 114.214549028687 all complications 4 4.53E-04 1.269379845 rs7677908 114.216837144526 all mi 4 2.50E-05 1.292302724 rs7677908 114.216837144526 all complications 4 3.74E-04 1.273706897 rs7677908 114.216837144526 peal complications 4 4.49E-04 1.273706897 rs1405164 114.218357624864 all mi 4 2.48E-05 1.293696828 rs1405164 114.218357624864 all complications 4 3.63E-04 1.275056319 rs1405164 114.218357624864 peal complications 4 4.49E-04 1.275056319 rs4615248 114.220351406474 all mi 4 2.58E-05 1.291666181 rs7655700 114.230079226689 all mi 4 9.99E-05 1.252999294 rs3844177 114.267230418442 all mi 4 9.52E-05 1.260706778 rs12647173 114.690863159531 all stroke 4 1.21 E-05 1.18642663 rs10012953 115.92044366078 peal mi 4 4.72E-04 0.727266465 rs6843082 116.451344641011 region-1 albu 4 6.26E-05 1.173096017 rs6843082 116.451344641011 all complications 4 3.71 E-04 1.135063393 rs17044494 116.737668430384 region-3 stroke 4 8.65E-06 8.967889908 rs1026975 116.858883898708 region-1 albu 4 4.34E-05 1.18801255 rs1026975 116.858883898708 all albu 4 1.42E-04 1.090133333 rs1385662 116.868857574007 region-1 mi 4 7.32E-05 1.508228813 rs1385662 116.868857574007 all mi 4 2.91 E-04 1.35952381 rs29336 116.896624163051 all stroke 4 7.16E-05 1.438714507 rs29336 116.896624163051 region-1 stroke 4 9.75E-05 1.595337128 rs29336 116.896624163051 peal stroke 4 1.40E-04 1.438714507 rs7654444 117.91450122604 all mi 4 7.64E-07 0.28112687 rs7654444 117.91450122604 peal mi 4 3.60E-06 0.28112687

Page 14 Table 1.xls

rs7654444 117.91450122604 region-3 mi 4 1.15E-04 0.137213254 rs1532885 127.300959398914 peal mi 4 3.36E-04 0.403409716 rs2055392 130.977285205065 region-1 complications 4 7.07E-05 0.809318845 rs2055392 130.977285205065 all complications 4 2.76E-04 0.862963512 rs17531334 131.509280212116 region-1 mi 4 3.87E-05 2.097307002 rs4600972 135.573872826622 all mi 4 3.37E-08 0.473248612 rs4600972 135.573872826622 peal mi 4 9.89E-08 0.473248612 rs4600972 135.573872826622 region-3 mi 4 5.01 E-07 0.292598112 rs1376088 138.424393483727 region-1 complications 4 3.74E-05 0.707497566 rs 1464435 141.664633726246 peal complications 4 2.29E-04 0.732987013 rs11736202 144.87465681791 region-1 stroke 4 3.97E-05 1.258945999 rs11736202 144.87465681791 all stroke 4 8.78E-05 1.158635394 rs11100741 144.876117898904 region-1 stroke 4 4.02E-05 1.257644763 rs11100741 144.876117898904 all stroke 4 8.87E-05 1.157782516 rs2070951 148.892139939234 region-3 mi 4 2.86E-05 1.610058172 rs2070950 148.893296617713 region-3 mi 4 2.52E-05 1.62182424 rs2070949 148.893723102515 region-3 mi 4 1.01 E-05 1.763227127 rs6852493 153.317601421566 peal mi 4 1.80E-04 0.505888377 rs1545904 154.178329778309 all stroke 4 1.26E-05 0.699641637 rs17029013 154.181593511896 all stroke 4 1.32E-05 0.697699267 rs7699961 154.787049305356 all mi 4 8.19E-05 0.291410379 rs7699961 154.787049305356 peal mi 4 2.08E-04 0.291410379 rs17031476 155.050909348114 all stroke 4 3.02E-05 2.688389665 rs17031476 155.050909348114 peal stroke 4 8.95E-05 2.688389665 rs6837016 155.55693502808 all complications 4 2.35E-05 0.784132662 rs6837016 155.55693502808 peal complications 4 2.49E-04 0.784132662 rs4463024 155.801788911741 region-1 mi 4 1.97E-05 1.490344168 rs4463024 155.801788911741 all mi 4 2.75E-04 1.49521877 rs4463024 155.801788911741 peal mi 4 3.49E-04 1.49521877 rs2880414 155.816610887403 all mi 4 2.92E-05 1.256994269 rs4330350 16.6201450243443 peal complications 4 2.99E-04 0.639077173 rs7660550 16.6281949126546 peal complications 4 1.75E-04 0.629532635 rs13353636 16.6284047242039 all complications 4 8.52E-05 0.691997779 rs13353636 16.6284047242039 peal complications 4 1.30E-04 0.691997779 rs7692314 16.6519735549025 peal complications 4 3.82E-04 0.652702137 rs2359630 16.893017390587 region-1 albu 4 2.76E-05 1.390695725 rs11736052 165.162806686612 region-3 stroke 4 5.89E-05 1.844405594 rs4691170 165.375858382929 region-3 complications 4 2.78E-05 0.403459698 rs17585174 165.38256659718 region-3 complications 4 4.64E-05 0.445194674 rs10017958 166.656866889917 region-3 stroke 4 2.42E-05 1.705312396 rs2710850 168.878418285625 peal mi 4 4.16E-04 0.765045362 rs2955262 170.519510582075 all stroke 4 2.57E-05 1.19977208 rs12505348 176.726905305657 all complications 4 1.98E-05 0.67296063 rs12505348 176.726905305657 peal complications 4 2.34E-05 0.67296063 rs17680943 177.972262979287 region-1 stroke 4 7.48E-05 1.845497157 rs2309396 182.685433054609 peal stroke 4 4.43E-04 1.372726083 rs7695194 183.291980888405 region-1 stroke 4 3.76E-05 1.466905615 rs1836655 183.297459726555 region-1 stroke 4 6.73E-05 1.461776983 rs1435495 183.29818508491 region-1 stroke 4 3.76E-05 1.523266423 rs10866247 183.298645713939 region-1 stroke 4 3.76E-05 1.499176975 rs7660520 187.498335359907 region-3 stroke 4 6.98E-05 1.906864477

Paαe 15 Table 1.xls

rs6552764 194.063836884602 peal mi 4 1.56E-04 0.551260357 rs10025265 200.094982938045 region-1 stroke 4 5.27E-05 1.655088452 rs13435843 200.109637685277 region- 1 stroke 4 4.82E-05 1.736990332 rs325032 202.408863982693 region-1 stroke 4 5.09E-05 1.607750473 rs4345174 22.2534813992671 peal complications 4 4.18E-04 1.300609832 rs3857156 25.6671709958409 peal stroke 4 3.72E-04 1.416330109 rs4608810 25.6940492819587 all stroke 4 4.76E-05 1.45384512 rs4608810 25.6940492819587 peal stroke 4 5.26E-05 1.45384512 rs2191003 28.9372692970805 region-3 complications 4 7.37E-05 1.720996371 rs2078622 29.1683795798255 peal mi 4 3.73E-04 1.307058634 rs6825008 32.1763792316107 all mi 4 2.98E-05 0.439348655 rs6825008 32.1763792316107 peal mi 4 4.73E-05 0.439348655 rs12645522 34.4293384812402 all albu 4 7.92E-05 0.810684876 rs2932966 36.427613554434 peal albu 4 1.35E-04 1.336451434 rs1472095 36.4524523282699 peal albu 4 4.80E-04 1.304147095 rs11931702 39.8281755447845 all mi 4 3.77E-05 1.342389972 rs11931702 39.8281755447845 region-1 mi 4 2.60E-04 1.373197915 rs11931702 39.8281755447845 peal mi 4 3.63E-04 1.342389972 rs6845684 40.5732502136018 peal stroke 4 4.39E-04 1.596843073 rs17680407 43.2767428059186 peal complications 4 1.15E-04 0.735778571 rs17680905 43.2825226461342 all complications 4 8.12E-05 0.731246181 rs17680905 43.2825226461342 peal complications 4 8.53E-05 0.731246181 rs17680905 43.2825226461342 all albu 4 4.18E-04 0.74981646 rs17680905 43.2825226461342 peal albu 4 4.36E-04 0.74981646 rs16880395 43.2847830924277 peal albu 4 1.62E-04 0.738859009 rs16880395 43.2847830924277 peal complications 4 4.63E-04 0.760539142 rs6448604 43.6334244746438 region-1 stroke 4 2.80E-05 1.73080481 rs6817648 43.894763470498 region-3 mi 4 9.17E-05 0.546112116 rs10517287 48.8878820148796 region-3 mi 4 1.38E-05 3.67533557 rs1655058 50.0752651643463 peal mi 4 2.55E-04 0.676578017 rs7679643 50.9266613947143 peal stroke 4 2.25E-04 0.604400271 rs12640317 50.9896106682983 region-1 stroke 4 2.88E-07 1.588981322 rs12640317 50.9896106682983 all stroke 4 7.43E-06 1.265709439 rs16988320 51.1634140522215 region-1 stroke 4 6.51 E-05 3.602523659 rs10016434 53.7389113831542 all mi 4 4.84E-08 0.03091138 rs10016434 53.7389113831542 region-1 mi 4 1.11 E-04 0 rs10016434 53.7389113831542 all stroke 4 1.34E-04 0.059640337 rs10016434 53.7389113831542 region-3 mi 4 2.23E-04 0.063467492 rs2585590 58.01742195738 peal complications 4 1.41 E-04 1.293804246 rs1380749 59.6754639693751 region-3 stroke 4 8.53E-05 1.028859625 rs1380749 59.6754639693751 all stroke 4 9.67E-05 1.176646312 rs7673088 60.3800265149569 all stroke 4 1.60E-05 3.363700815 rs7673088 60.3800265149569 peal stroke 4 4.76E-05 3.363700815 rs7673088 60.3800265149569 region-1 stroke 4 4.35E-04 3.206552707 rs17609346 60.5017606353206 region-1 mi 4 8.62E-05 0.456499577 rs17609346 60.5017606353206 all mi 4 3.22E-04 0.600564217 rs12504135 63.8108767472697 all stroke 4 4.36E-05 0.778045526 rs2282775 64.0030341002257 all stroke 4 5.37E-05 1.351628737 rs3020821 64.0155664645688 all stroke 4 3.16E-05 1.340320036 rs4336286 65.8686654842716 region-3 complications 4 9.08E-05 0.649212431 rs13101326 65.9249159766753 region-3 complications 4 8.19E-05 0.658230817

Paαe 16 Table 1.xls

rs4571397 65.9566852731063 all complications 4 9.76E-05 1.310153037 rs4571397 65.9566852731063 peal complications 4 1.22E-04 1.310153037 rs4571397 65.9566852731063 regioπ-1 complications 4 2.76E-04 1.34305359 rs4864949 65.9815506723306 peal complications 4 4.62E-04 0.780051238 rs6825958 66.0374738078821 peal complications 4 3.76E-04 0.75078996 rs1450900 72.4731355114682 region-3 stroke 4 9.02E-05 1.54579187 rs7690962 72.4739911619802 region-3 stroke 4 9.58E-05 1.546397565 rs996967 73.1799250404888 all mi 4 4.14E-07 0.242259414 rs996967 73.1799250404888 peal mi 4 2.84E-06 0.242259414 rs996967 73.1799250404888 region-1 mi 4 1.50E-04 0.20519764 rs996967 73.1799250404888 region-3 mi 4 3.36E-04 0.218754259 rs13105340 73.5081114359857 region-3 albu 4 6.80E-05 0.597715128 rs6827825 76.8846844764932 region-1 stroke 4 8.91 E-05 1.334476609 rs12504640 77.4170543980128 peal stroke 4 3.03E-04 0.676410847 rs6821995 77.6296441593416 region-3 albu 4 2.71 E-05 1.445299431 rs6849403 77.6315556062921 region-3 albu 4 2.60E-05 1.469482976 rs2013685 78.5720452723064 all albu 4 5.66E-05 0.837073667 rs1842474 78.5857252357761 region-1 albu 4 2.27E-05 1.068782196 rs6600814 78.5875837302477 all albu 4 7.59E-05 0.847949073 rs6600814 78.5875837302477 region-1 albu 4 4.56E-04 0.813224627 rs4694381 78.9153434140182 peal stroke 4 4.08E-04 1.428630655 rs6836327 80.3758465032764 all mi 4 4.98E-07 0.066715382 rs6836327 80.3758465032764 region-3 complications 4 1.88E-04 0.274406332 rs6836327 80.3758465032764 peal mi 4 1.95E-04 0.066715382 rs6836327 80.3758465032764 all stroke 4 2.31 E-04 0.063557774 rs6836327 80.3758465032764 region-3 mi 4 4.52E-04 0.067285862 rs1350775 80.6874262688996 region-3 complications 4 2.73E-05 2.2 rs4519770 80.6882708186991 region-3 complications 4 2.16E-05 2.221247563 rs4995246 80.6979657321692 region-3 complications 4 4.20E-05 1.925659472 rs4610413 82.0473263480509 peal mi 4 3.57E-04 0.55834451 rs3796473 82.8881003702497 all mi 4 2.48E-05 1.297753777 rs4859543 82.9000835845188 all mi 4 9.66E-06 1.323420477 rs7691765 82.9143680552885 all mi 4 3.77E-05 1.296512043 rs4859547 82.9154960110609 all mi 4 1.14E-05 1.318979542 rs7677150 82.9286792471928 all mi 4 2.32E-06 1.334472176 rs10014281 82.9286881542376 all mi 4 9.00E-06 1.323413986 rs7691385 82.9320647339729 all mi 4 9.00E-06 1.323413986 rs3853184 82.9497897532546 all mi 4 3.84E-05 1.305721306 rs1905581 86.6102651863698 region-1 stroke 4 1.70E-05 0.578347578 rs10518199 86.627204509292 region-1 stroke 4 1.70E-05 0.578347578 rs7681711 90.5500627151247 region-1 complications 4 1.46E-05 1.159541189 rs7682126 90.5506762976135 region-1 complications 4 1.10E-05 1.153269582 rs13106297 90.5977752351312 region-1 complications 4 9.10E-06 1.175493175 rs2572318 99.2277016231667 region-1 stroke 4 9.02E-05 1.673203915 rs2572318 99.2277016231667 all stroke 4 2.06E-04 1.474923877 rs2572318 99.2277016231667 peal stroke 4 2.61 E-04 1.474923877 rs1811442 99.2329392427314 region-1 stroke 4 6.38E-05 1.685233428 rs1811442 99.2329392427314 all stroke 4 2.62E-04 1.463871363 rs1811442 99.2329392427314 peal stroke 4 3.21 E-04 1.463871363 rs1471484 99.2341230833068 peal stroke 4 2.63E-04 1.48492905 rs17218334 99.5456972219836 region-1 mi 4 1.66E-06 1.38794499

Page 17 Table 1.xls

rs17218334 99.5456972219836 all mi 4 3.69E-05 1.263300124 rs1450827 10.1607883333262 peal complications 5 4.65E-04 0.750643118 rs6869049 106.200283385439 all stroke 5 7.71 E-05 1.176839789 rs6869049 106.200283385439 region-1 stroke 5 1.24E-04 1.265119008 rs17137871 108.386249326522 all stroke 5 2.68E-05 1.087422629 rs17334370 109.056173946108 all mi 5 6.18E-30 0.146895144 rs17334370 109.056173946108 peal mi 5 1.20E-23 0.146895144 rs17334370 109.056173946108 region-1 mi 5 3.94E-21 0.146367261 rs17334370 109.056173946108 all stroke 5 1.73E-17 0.143858572 rs17334370 109.056173946108 peal stroke 5 1.24E-13 0.143858572 rs17334370 109.056173946108 region-1 stroke 5 4.47E-11 0.160271448 rs17334370 109.056173946108 all complications 5 2.64E-06 0.639074301 rs17334370 109.056173946108 region-1 albu 5 2.99E-06 1.584229247 rs17334370 109.056173946108 peal complications 5 3.14E-06 0.639074301 rs17334370 109.056173946108 all albu 5 1.46E-05 1.46849367 rs17334370 109.056173946108 peal albu 5 5.46E-05 1.46849367 rs10463573 112.864476982118 region-1 complications 5 5.14E-05 1.291560102 rs10463573 112.864476982118 all complications 5 1.58E-04 1.235138659 rs1438698 117.566296061416 peal complications 5 3.23E-04 1.51415184 rs10051407 117.584175452648 peal complications 5 4.81 E-04 1.548511905 rs1345683 117.708973231797 peal mi 5 4.95E-04 1.526377491 rs4391218 117.768486439853 peal mi 5 3.51 E-04 1.604047892 rs3101088 121.46501765183 region-3 complications 5 2.43E-05 0.512288136 rs2125143 121.494893270121 region-3 complications 5 5.99E-05 0.530898457 rs3852203 124.025555049121 region-1 complications 5 9.81 E-05 0.652163157 rs3852203 124.025555049121 all complications 5 1.00E-04 0.700884865 rs3852203 124.025555049121 peal complications 5 3.32E-04 0.700884865 rs2560606 127.361185577779 peal mi 5 3.53E-04 1.305483901 rs10077522 129.873978863234 all mi 5 8.22E-06 0.164143684 rs10077522 129.873978863234 peal mi 5 1.18E-04 0.164143684 rs10077522 129.873978863234 region-1 mi 5 1.77E-04 0.179175865 rs1421883 130.142397209718 region-1 stroke 5 1.38E-05 1.231172869 rs246277 130.310423064528 all albu 5 2.62E-06 1.568234065 rs246277 130.310423064528 peal albu 5 3.16E-06 1.568234065 rs246277 130.310423064528 region-1 albu 5 4.07E-05 1.641370869 rs28891 130.320717231862 all albu 5 5.19E-06 1.553451969 rs28891 130.320717231862 peal albu 5 6.16E-06 1.553451969 rs28891 130.320717231862 region-1 albu 5 6.93E-05 1.624155143 rs982926 130.337696211184 peal albu 5 4.70E-04 1.297659709 rs12055256 130.34144946426 all albu 5 4.23E-05 1.488021238 rs12055256 130.34144946426 peal albu 5 4.74E-05 1.488021238 rs4333309 130.3480878192 all albu 5 2.11 E-05 1.514855201 rs4333309 130.3480878192 peal albu 5 2.44E-05 1.514855201 rs13436111 131.165657258332 all stroke 5 4.56E-05 1.397699047 rs13166738 131.69531682283 all stroke 5 9.54E-05 0.473481552 rs13166738 131.69531682283 peal stroke 5 1.29E-04 0.473481552 rs331783 132.016000716777 all mi 5 2.16E-05 0.618993057 rs331783 132.016000716777 peal mi 5 3.02E-05 0.618993057 rs331742 132.018816320348 all mi 5 3.78E-05 0.621952669 rs331742 132.018816320348 peal mi 5 5.41 E-05 0.621952669 rs17165007 132.231141264188 peal complications 5 4.06E-04 0.708425929

Page 18 Table 1.xls

rs10519913 132.498340217841 region-3 stroke 5 4.82E-05 4.609175871 rs255574 134.370134931426 all stroke 5 3.39E-07 1.338334354 rs2706364 135.708813343363 all mi 5 3.92E-06 0.217150844 rs2706364 135.708813343363 peal mi 5 2.63E-05 0.217150844 rs2706364 135.708813343363 region-1 mi 5 5.38E-05 0.054713545 rs11242144 136.602159279533 all complications 5 3.01 E-05 0.898379971 rs4958117 136.760527424707 region-1 mi 5 6.42E-05 1.385599711 rs30751 139.416902405653 region-3 mi 5 2.85E-05 5.014705882 rs30751 139.416902405653 all mi 5 3.71 E-05 2.36392833 rs30751 139.416902405653 peal mi 5 9.63E-05 2.36392833 rs6891143 143.793840887243 peal mi 5 1.64E-04 1.441490606 rs248528 143.943311754421 all stroke 5 1.52E-05 1.820143047 rs248528 143.943311754421 peal stroke 5 1.83E-05 1.820143047 rs248528 143.943311754421 region-1 stroke 5 4.11 E-04 1.927097016 rs3853477 145.304065397484 region-3 mi 5 7.69E-05 0.580874605 rs17796864 147.747580886647 peal albu 5 4.92E-04 1.296885208 rs2024055 147.7528324927 peal albu 5 2.13E-04 1.320520521 rs12188581 147.771888983276 peal albu 5 2.40E-04 1.314220673 rs34170515 147.773439447836 peal albu 5 2.99E-04 1.308778766 rs17492851 147.793060844173 peal albu 5 2.40E-04 1.314220673 rs17492893 147.793140536236 peal albu 5 2.43E-04 1.31582427 rs17427286 147.794059516857 peal albu 5 3.29E-04 1.306288226 rs2895647 147.797088823998 peal albu 5 2.52E-04 1.312751151 rs13153675 147.824332413061 peal albu 5 2.50E-04 1.314608983 rs17428570 147.826571860897 peal albu 5 3.77E-04 1.303081048 rs187994 15.0454582955016 region-3 complications 5 5.64E-05 0.662864841 rs187994 15.0454582955016 all mi 5 2.49E-04 0.836847195 rs2034877 15.2999927145355 region-3 albu 5 8.60E-05 1.601890756 rs17725010 151.053402349877 region-3 albu 5 1.63E-05 2.297454039 rs3776069 151.057952593667 region-3 albu 5 1.88E-05 2.267801164 rs2277924 151.079237805097 region-3 albu 5 1.12E-06 2.265151515 rs2277924 151.079237805097 all albu 5 2.69E-04 1.358137251 rs10070447 156.79449376622 peal albu 5 3.05E-04 0.772842279 rs10072570 156.795548639937 peal complications 5 3.05E-04 0.760371865 rs2926862 156.83146969119 all albu 5 4.13E-05 1.428630705 rs2926862 156.83146969119 peal albu 5 4.41 E-05 1.428630705 rs2926862 156.83146969119 region-1 albu 5 8.54E-05 1.481400675 rs2964003 156.836466228395 region-1 albu 5 5.48E-05 1.509155556 rs2964003 156.836466228395 all albu 5 7.76E-05 1.416312633 rs2964003 156.836466228395 peal albu 5 8.67E-05 1.416312633 rs1461237 156.860364154457 peal albu 5 1.57E-04 1.392336625 rs7714857 157.993148475601 all mi 5 3.09E-07 0.090750744 rs7714857 157.993148475601 peal mi 5 4.78E-05 0.090750744 rs7714857 157.993148475601 all stroke 5 8.96E-05 0.057009889 rs7714857 157.993148475601 region-1 mi 5 2.20E-04 0.062666329 rs256772 158.078192556256 region-1 mi 5 4.14E-05 1.422125124 rs11743536 159.532729654391 peal complications 5 2.23E-04 1.438183647 rs4704859 159.543498555922 all stroke 5 5.93E-05 0.678052364 rs4704859 159.543498555922 peal stroke 5 6.51 E-05 0.678052364 rs4704859 159.543498555922 region-3 stroke 5 4.98E-04 0.562763636 rs175851 160.370096953161 region-3 complications 5 3.87E-05 1.346569873

Page 19 Table1.xls

rs2116732 162.291327450135 all complications 5 3.98E-05 0.30066846 rs2116732 162.291327450135 peal complications 5 1.96E-04 0.30066846 rs4314444 162.516226203938 peal mi 5 1.45E-04 1.410930843 rs398934 163.009626723867 region-1 mi 5 9.30E-05 1.448571986 rs1363697 163.127678215456 all albu 5 7.00E-05 0.73989086 rs1363697 163.127678215456 peal albu 5 1.05E-04 0.73989086 rs1368378 172.070891093218 all mi 5 1.48E-05 0.825765613 rs2221440 176.847808995789 all stroke 5 5.78E-05 1.267271111 rs11134649 177.1027938313 peal complications 5 2.71 E-04 1.287188254 rs2673891 21.8381540727982 region-3 complications 5 1.57E-07 0.570002879 rs2400141 23.3206426249754 region-1 stroke 5 8.75E-06 1.456923077 rs557292 25.8142361695119 region-1 stroke 5 4.65E-05 2.625695054 rs809565 25.8146139638504 region-1 stroke 5 3.49E-05 2.669043375 rs831663 28.5092820553218 all mi 5 2.34E-06 0.15135274 rs831663 28.5092820553218 peal mi 5 4.55E-05 0.15135274 rs831663 28.5092820553218 all stroke 5 7.35E-05 0.055792447 rs6554923 28.5131015001514 all mi 5 5.10E-05 0.209902371 rs6554923 28.5131015001514 peal mi 5 3.19E-04 0.209902371 rs6554923 28.5131015001514 all complications 5 4.50E-04 0.472492267 rs17649710 28.5533623429922 region-1 mi 5 2.93E-05 1.489576872 rs9293123 37.3191727499998 peal albu 5 4.38E-04 1.320270505 rs7732575 37.6623193280292 peal complications 5 2.91 E-04 1.331313131 rs1896890 37.6716330071242 peal complications 5 3.36E-04 1.327272727 rs6891806 37.6734307015981 peal complications 5 3.25E-04 1.328503563 rs1966590 37.7375059153781 peal stroke 5 2.73E-04 1.838274811 rs10050805 40.916045756487 region-1 stroke 5 8.09E-06 4.948275862 rs16900399 40.9512000425324 peal complications 5 2.01 E-04 0.679352997 rs2962792 41.0510622209781 region-1 albu 5 4.54E-05 0.4795086 rs2962792 41.0510622209781 all albu 5 5.34E-05 0.576184409 rs2962792 41.0510622209781 peal albu 5 1.38E-04 0.576184409 rs186544 45.4577826526895 region-3 complications 5 9.58E-05 1.523809524 rs10941073 49.0913334592195 all mi 5 5.45E-08 0.08411215 rs10941073 49.0913334592195 peal mi 5 1.98E-05 0.08411215 rs10941073 49.0913334592195 region-1 mi 5 5.37E-05 0 rs35406 49.6871127964845 region-3 stroke 5 6.42E-05 5.641211323 rs35406 49.6871127964845 all stroke 5 2.96E-04 2.532894737 rs424339 5.65432076972433 region-3 albu 5 7.28E-06 1.805609472 rs380259 5.66939733707078 region-3 albu 5 4.22E-06 1.832040209 rs323684 5.69377026543544 region-3 albu 5 3.86E-06 1.839920949 rs2194251 51.4824568409914 all albu 5 7.59E-05 1.243686805 rs4869544 54.3446297974441 all mi 5 1.78E-09 0.323577425 rs4869544 54.3446297974441 peal mi 5 2.64E-08 0.323577425 rs4869544 54.3446297974441 all complications 5 9.28E-08 0.530771923 rs4869544 54.3446297974441 all stroke 5 2.40E-07 0.251846193 rs4869544 54.3446297974441 region-1 mi 5 1.10E-06 0.311995505 rs4869544 54.3446297974441 peal complications 5 1.34E-06 0.530771923 rs4869544 54.3446297974441 peal stroke 5 3.17E-06 0.251846193 rs4869544 54.3446297974441 region-3 mi 5 2.70E-05 0.212327105 rs4869544 54.3446297974441 region-1 complications 5 1.01 E-04 0.582136182 rs4869544 54.3446297974441 region-3 complications 5 1.33E-04 0.380143337 rs4869544 54.3446297974441 region-3 stroke 5 3.57E-04 0.18855042

Page 20 Table LxIs

rs4869544 54.3446297974441 regιon-1 stroke 5 4.02E-04 0.31283817 rs17353566 56.033342455328 all albu 5 4.91 E-05 1.007271945 rs17353566 56.033342455328 region-1 albu 5 4.98E-04 0.9951184 rs320615 59.2783434716828 region-1 stroke 5 6.18E-05 0.594984265 rs3846498 59.7780035122515 region-1 stroke 5 2.51 E-05 1.603687856 rs2974658 6.37496565631477 region-3 stroke 5 4.97E-05 1.012524866 rs468700 6.80050035942518 region-3 mi 5 8.07E-05 0.370537054 rs468700 6.80050035942518 all mi 5 1.39E-04 0.630709946 rs468700 6.80050035942518 peal mi 5 4.59E-04 0.630709946 rs9313037 6.84996122164993 region-3 albu 5 4.21 E-05 1.688414335 rs1215658 6.8501824824739 region-3 albu 5 9.26E-06 1.752982955 rs2404273 6.85037109825827 region-3 albu 5 2.41 E-05 1.714087302 rs2165515 6.86162275524134 region-3 albu 5 1.34E-05 0.584808681 rs2165515 6.86162275524134 region-3 mi 5 2.54E-04 1.494144597 rs1215664 6.88606300822391 region-3 albu 5 3.20E-05 1.71779481 rs1215665 6.88692628816007 region-3 albu 5 1.26E-06 1.954890788 rs1215665 6.88692628816007 region-3 mi 5 4.07E-04 0.624310974 rs286003 64.0536728854063 region-1 albu 5 1.91E-06 1.228528753 rs286003 64.0536728854063 all albu 5 1.74E-05 1.179022613 rs10471462 68.6773216394885 all complications 5 3.67E-06 0.655387884

_CJl rs10471462 68.6773216394885 peal complications 5 5.85E-06 0.655387884 rs10471462 68.6773216394885 all albu 5 1.81 E-05 0.662908055 rs10471462 68.6773216394885 peal albu 5 2.75E-05 0.662908055 rs10471462 68.6773216394885 region-1 albu 5 2.11 E-04 0.658624849 rs10071774 68.6778492818504 all complications 5 4.70E-06 0.659792509 rs10071774 68.6778492818504 peal complications 5 7.08E-06 0.659792509 rs10071774 68.6778492818504 all albu 5 1.42E-05 0.660928778 rs10071774 68.6778492818504 peal albu 5 2.10E-05 0.660928778 rs10071774 68.6778492818504 region-1 albu 5 2.12E-04 0.660368512 rs11951359 68.6838756257417 all complications 5 4.70E-06 0.659792509 ^ rs11951359 68.6838756257417 peal complications 5 7.08E-06 0.659792509 rs11951359 68.6838756257417 all albu 5 1.42E-05 0.660928778 rs11951359 68.6838756257417 peal albu 5 2.10E-05 0.660928778 rs11951359 68.6838756257417 region-1 albu 5 2.12E-04 0.660368512 rs12657171 68.690560237742 all complications 5 4.72E-05 0.586970534 rs12657171 68.690560237742 peal complications 5 5.60E-05 0.586970534 rs1498600 68.7170901128291 all stroke 5 3.22E-05 1.467741935 rs1498600 68.7170901128291 peal stroke 5 4.02E-05 1.467741935 rs1498599 68.7178948530872 all stroke 4.85E-05 1.455802151 rs1498599 68.7178948530872 peal stroke 5 6.10E-05 1.455802151 rs32710 7.66944602357038 region-1 albu 5 9.91 E-05 1.389774798 rs10514926 70.0236521377796 peal complications 5 3.77E-04 2.117652556 rs11949052 71.7316166440307 region-1 complications 5 3.43E-05 0.613774115 rs11949052 71.7316166440307 all complications 5 5.59E-05 0.676405112 rs11949052 71.7316166440307 peal complications 5 2.40E-04 0.676405112 rs11949052 71.7316166440307 region-1 albu 5 3.32E-04 0.616839976 rs6449750 72.1311606639622 all mi 5 6.24E-07 0.118663194 rs6449750 72.1311606639622 peal mi 5 3.35E-05 0.118663194 rs6449750 72.1311606639622 region-3 mi 5 1.77E-04 0.06184098 rs6449750 72.1311606639622 all stroke 5 2.29E-04 0.11278575 rs338668 74.7488612687525 region-1 mi 5 9.19E-05 1.306122449

Paαe 21 Table 1.xls

rs338668 74.7488612687525 all mi 5 4.57E-04 1.234368664 rs4583865 75.7557330690221 region-1 mi 5 4.31 E-05 1.393630809 rs4583865 75.7557330690221 all mi 5 1.51 E-04 1.124069479 rs3915457 75.7564788127045 region-1 mi 5 4.31 E-05 1.378911062 rs3915457 75.7564788127045 all mi 5 1.51 E-04 1.115746478 rs1903262 82.015753764165 peal complications 5 4.69E-04 0.750250076 rs168534 91.8121574087919 all stroke 5 6.35E-05 1.303166678 rs355285 91.8201137425055 all stroke 5 9.87E-05 1.298189655 rs33612 93.68063618189 all complications 5 2.08E-05 0.730993913 rs33612 93.68063618189 peal complications 5 2.27E-05 0.730993913 rs309572 93.7509592772973 region-1 albu 5 8.15E-05 1.227709878 rs309572 93.7509592772973 all albu 5 3.46E-04 1.155310402 rs680209 93.7556789029441 region-1 albu 5 7.04E-05 1.227333745 rs680209 93.7556789029441 all albu 5 3.68E-04 1.151980294 rs569733 93.7585594645426 region-1 albu 5 8.36E-05 1.244487546

γS569733 93.7585594645426 all albu 5 3.54E-04 1.162456262 rs3777048 93.7806360016264 region-1 albu 5 2.02E-05 1.251962961 rs3777048 93.7806360016264 all albu 5 3.38E-04 1.180166961 rs10474222 95.1946178224666 peal mi 5 2.05E-04 0.527828951 rs1331484 0.897154369502377 all albu 6 3.99E-05 1.350128151 rs1331484 0.897154369502377 peal albu 6 6.50E-05 1.350128151 rs4959523 1.03112673614256 peal stroke 6 2.57E-04 1.525275882 rs10484953 1.03471896940352 peal stroke 6 2.75E-04 1.522766104 rs9362923 100.963388048561 all albu 6 6.35E-05 0.801206797 rs16870107 101.513018876037 region-3 mi 6 2.24E-05 0.19556962 rs16870107 101.513018876037 region-3 stroke 6 5.37E-05 0.09789823 rs12207570 103.383586708241 peal mi 6 3.87E-04 0.696616013 rs2064947 103.411408911421 peal mi 6 4.76E-04 0.702143805 rs6923212 103.415348710379 peal mi 6 2.51 E-04 0.68720776 rs17806588 103.707894008677 peal complications 6 4.18E-04 1.88216141 rs7748736 11.5081596269164 peal albu 6 1.57E-04 1.293958879 rs7748736 11.5081596269164 peal complications 6 4.70E-04 1.272043011 rs9502593 11.5117329185042 peal albu 6 2.25E-04 1.284204238 rs9502593 11.5117329185042 peal complications 6 3.87E-04 1.27444795 rs1359437 11.5521887008529 peal complications 6 2.72E-04 0.764958944 rs2503293 111.383195144333 all albu 6 6.47E-05 0.757302205 rs2503293 111.383195144333 peal albu 6 1.29E-04 0.757302205 rs2503293 111.383195144333 all complications 6 3.02E-04 0.829018833 rs2503293 111.383195144333 region-1 albu 6 4.04E-04 0.760364057 rs9391062 111.41111323681 all albu 6 9.70E-05 0.755919614 rs9391062 111.41111323681 peal albu 6 1.12E-04 0.755919614 rs11156316 111.418804014744 peal albu 6 1.36E-04 0.758606315 rs9485946 112.085773294521 all stroke 6 6.63E-05 1.219323006 rs4946666 113.339199363433 region-3 stroke 6 4.72E-05 1.826873065 rs4945729 113.534461658376 region-1 stroke 6 9.44E-05 1.293171806 rs9791179 113.534574852694 region-1 stroke 6 9.28E-05 1.297603201 rs6909578 115.972366432878 all mi 6 2.30E-08 0.055853877 rs6909578 115.972366432878 region-1 mi 6 3.55E-05 0 rs6909578 115.972366432878 peal mi 6 5.05E-05 0.055853877 rs6909578 115.972366432878 region-3 mi 6 9.82E-05 0.057938965 rs6909578 115.972366432878 all stroke 6 1.38E-04 0.107568902

Paαe 22 Table LxIs

rs540391 119.720161637538 all stroke 6 7.93E-05 2.085339754 rs540391 119.720161637538 peal stroke 6 1.30E-04 2.085339754 rs3901856 121.30685249789 peal mi 6 3.67E-04 1.435065828 rs17825393 121.372729737864 peal mi 6 3.49E-04 0.764288179 rs7760976 122.186984857327 region-1 albu 6 4.12E-05 1.506885321 rs332607 123.915968521909 regioπ-3 albu 6 7.55E-05 1.779706999 rs9320994 123.962465883347 region-3 stroke 6 3.62E-07 2.786591902 rs478907 132.826761088825 region-3 albu 6 4.69E-05 1.865076751 rs6913726 132.838842389154 regioπ-3 albu 6 5.05E-05 1.680272109 rs6913726 132.838842389154 region-1 mi 6 1.38E-04 0.761123061 rs9385650 132.881227169023 region-3 albu 6 7.80E-05 1.829084042 rs2473091 139.431175213958 region-1 mi 6 3.43E-05 0.587244284 rs2473092 139.431905294172 region-1 mi 6 7.05E-05 0.620586475 rs1556640 139.551416040752 region-1 mi 6 6.56E-05 0.54207523 rs4896449 141.27193585099 all stroke 6 9.01 E-05 1.435971866 rs4896449 141.27193585099 peal stroke 6 1.30E-04 1.435971866 rs17258731 146.07857633911 region-3 albu 6 6.71 E-05 2.743847875 rs17258731 146.07857633911 all albu 6 1.84E-04 1.566593682 rs17258731 146.07857633911 peal albu 6 2.07E-04 1.566593682 rs6570889 148.22203184454 region-1 stroke 6 5.39E-08 0.524889729

_CJ) rs9403979 148.268748402859 region-1 stroke 6 7.45E-07 0.548009702 rs6570893 148.276605635978 region-1 stroke 6 8.01 E-07 0.548947272 rs9328513 15.3886768890518 peal mi 6 2.62E-04 0.746884462 rs9328513 15.3886768890518 peal complications 6 2.90E-04 0.775477335 rs654694 151.949718360103 all stroke 6 2.33E-05 1.284820065 rs654694 151.949718360103 region-1 stroke 6 2.35E-04 1.263265306 rs11752725 153.688064175937 region-3 stroke 6 4.22E-05 0.450890347 rs9384257 156.186512345637 region-3 stroke 6 2.75E-05 2.572783505 rs1537583 159.511316621447 peal complications 6 2.01 E-04 0.769021013 rs2209543 16.201388288052 peal stroke 6 2.36E-04 1.406230816 rs6925350 164.398156226586 peal albu 6 3.03E-04 1.364444881 rs9364534 164.398818907299 peal albu 6 2.05E-04 1.375446152 rs2146162 164.46923522993 peal albu 6 1.85E-04 1.379740455 rs7764326 164.544774334347 peal albu 6 1.32E-04 1.390869752 rs9457730 164.597460699469 all albu 6 3.16E-05 1.392585403 rs9457730 164.597460699469 peal albu 6 3.45E-05 1.392585403 rs3019442 166.369310287848 peal mi 6 4.96E-04 1.296475205 rs6926642 166.618342124539 peal albu 6 4.70E-04 1.266864046 rs6930668 168.666159630982 region-3 albu 6 2.61 E-05 0.612874591 rs6455807 168.725375303325 region-3 albu 4.82E-05 0.617190609 rs6931162 170.133238016092 region-3 complications 6 9.29E-05 0.401785714 rs1012424 170.223511124542 region-3 complications 6 1.03E-05 1.973180077 rs4710013 178.747061564539 peal complications 6 3.33E-04 1.54494058 rs7751204 184.949948991962 peal stroke 6 4.16E-04 0.648077778 rs9364250 185.806377766112 peal albu 6 2.17E-04 0.763246654 rs4710884 191.830306755511 region-1 albu 6 5.53E-05 1.363244696 rs1537340 23.9072157988281 region-3 mi 6 6.43E-05 0.61038961 rs7750679 23.9167076563648 region-3 mi 6 6.99E-05 0.626262626 rs1332845 23.9178682635483 region-3 mi 6 6.54E-05 0.605218378 rs1332847 23.9181677102501 region-3 mi 6 6.54E-05 0.605218378 rs9296512 23.9203281478644 region-3 mi 6 5.32E-05 0.622466095

Paαe 23 Table 1.xls

rs13219256 23.9237325956025 region-3 mi 6 8.40E-05 0.605218378 rs12526453 23.9531266054124 region-3 mi 3.81 E-05 0.588941362 rs6936420 24.4457013571819 peal stroke 6 3.10E-04 1.793677058 rs9357738 24.4859387541058 region-1 stroke 6 3.20E-05 1.767252828 rs9357738 24.4859387541058 all stroke 6 1.14E-04 1.526530426 rs9357738 24.4859387541058 peal stroke 6 1.81E-04 1.526530426 rs2841573 24.584773048609 region-1 stroke 6 5.12E-05 2.516274238

γS6940337 24.856230134595 region-1 stroke 6 8.39E-06 2.588372093

γS853360 25.4954062788083 region-3 albu 6 1.50E-06 2.107471264 rs794783 28.1994411890028 all mi 6 2.19E-05 1.55636675 rs794783 28.1994411890028 peal mi 6 2.50E-05 1.55636675 rs794783 28.1994411890028 region-3 mi 6 4.70E-05 2.036329412 rs2237143 28.5088491224269 region-3 mi 6 4.63E-06 1.892698669 rs1014534 33.5705389542036 peal complications 6 2.92E-04 1.361907319 rs9477555 33.5716893657213 peal complications 6 2.75E-04 1.360906625 rs1495977 34.041228714568 region-1 stroke 6 9.02E-05 1.257112249 rs1202201 34.7508689573419 peal complications 6 3.80E-04 1.300476234 rs586124 34.7875620359709 peal complications 6 2.03E-04 1.294772726 rs4546534 4.92956461018162 peal stroke 6 2.29E-04 1.399224526 rs199031 40.0511762096637 all complications 6 7.56E-05 1.437459394 rs199031 40.0511762096637 peal complications σ ^> 6 8.27E-05 1.437459394 rs9379660 41.591407551191 region-1 complications 6 2.01 E-05 1.245804342 rs3181227 41.973070556218 region-3 mi 6 5.94E-05 0.575915209 rs2066951 44.2962872917827 peal stroke 6 2.32E-04 2.414996964 rs6933331 44.3082956238212 all stroke 6 9.58E-05 3.319113802 rs6933331 44.3082956238212 peal stroke 6 2.13E-04 3.319113802 rs3025657 44.3129869718972 peal stroke 6 4.35E-04 3.228530466 rs3099848 44.854725218913 peal complications 6 4.26E-04 0.760849359 rs2736172 44.9252179049621 all albu 6 1.94E-05 1.34255616 rs2736172 44.9252179049621 peal albu 6 2.24E-05 1.34255616 rs2736172 44.9252179049621 all complications 6 3.75E-05 1.337543972 rs2736172 44.9252179049621 peal complications 6 4.26E-05 1.337543972 rs9469220 45.672551446058 peal complications 6 3.34E-04 1.281475503 rs9461799 45.695985640688 all complications 6 6.40E-06 1.367894033 rs9461799 45.695985640688 peal complications 6 8.27E-06 1.367894033 rs9469240 45.6963399422308 all complications 6 2.15E-05 1.341586314 rs9469240 45.6963399422308 peal complications 6 2.71 E-05 1.341586314 rs2227127 45.7126896072821 all complications 6 6.54E-06 1.365969122 rs2227127 45.7126896072821 peal complications 6 9.33E-06 1.365969122 rs9276429 45.7129313129957 all complications 6 1.87E-05 0.743152664 rs9276429 45.7129313129957 peal complications 6 2.54E-05 0.743152664 rs9276431 45.7130386543529 all complications 6 2.04E-05 0.746325069 rs9276431 45.7130386543529 peal complications 6 2.62E-05 0.746325069 rs9276432 45.713141491877 all complications 6 1.94E-05 0.745713577 rs9276432 45.713141491877 peal complications 6 2.53E-05 0.745713577 rs9276440 45.7149422745067 all complications 6 2.28E-05 0.74758707

γS9276440 45.7149422745067 peal complications 6 3.04E-05 0.74758707 rs9276490 45.7178682647905 all complications 6 1.47E-05 0.742739357 rs9276490 45.7178682647905 peal complications 6 2.10E-05 0.742739357 rs7768538 45.7262303817121 all complications 6 3.10E-05 0.751220159 rs7768538 45.7262303817121 peal complications 6 3.90E-05 0.751220159

Page 24 Table 1.xls

rs7453920 45.7263737537348 all complications 6 2.66E-05 0.749329168 rs7453920 45.7263737537348 peal complications 6 3.34E-05 0.749329168 rs2051549 45.7264293010106 all complications 6 2.66E-05 0.749222715 rs2051549 45.7264293010106 peal complications 6 3.45E-05 0.749222715 rs6903130 45.7280236579533 all complications 6 2.43E-05 1.332479839 rs6903130 45.7280236579533 peal complications 6 3.50E-05 1.332479839 rs6903130 45.7280236579533 all stroke 6 4.98E-04 1.375733471 rs9296043 45.7309458950427 all complications 6 4.47E-06 1.370624577 rs9296043 45.7309458950427 peal complications 6 5.91 E-06 1.370624577 rs9296044 45.730976671236 all complications 6 2.59E-06 1.380596242 rs9296044 45.730976671236 peal complications 6 3.45E-06 1.380596242 rs1015575 45.7324561804328 all complications 6 5.42E-06 1.369966015 rs1015575 45.7324561804328 peal complications 6 8.00E-06 1.369966015 rs1413896 48.1033457516153 peal complications 6 4.80E-04 1.38681592 rs236369 50.0659018483656 all mi 6 2.70E-05 0.321167131 rs236369 50.0659018483656 peal mi 6 1.27E-04 0.321167131 rs236369 50.0659018483656 region- 1 mi 6 1.79E-04 0.289462029 rs9394508 52.7634405188292 region- 1 stroke 6 9.05E-05 1.454041402 rs2252550 52.8078634856027 region-1 mi 6 8.45E-05 1.350996769 rs2252550 52.8078634856027 all mi 6 3.59E-04 1.288624312 rs1699002 52.8515332049953 region-1 mi 6 9.61 E-05 1.357635692 rs1699001 52.860612670737 region-1 mi 6 5.64E-05 1.363877695 rs9296318 55.2743237738768 region-1 stroke 6 1.48E-05 1.337079171 rs4594945 55.2762298902905 region-1 stroke 6 8.02E-06 1.29808514 rs10807222 55.4449379132236 region-1 stroke 6 2.69E-05 1.326056985 rs1007026 55.9857733651355 region-1 stroke 6 2.55E-05 1.294652884 rs10947854 56.2155523547447 region-1 stroke 6 4.79E-05 1.290497392 rs10807224 56.2673519043034 region-1 stroke 6 2.77E-05 1.299751131 rs6912289 56.3242595114444 region-1 stroke 6 2.66E-05 1.299034645 rs10947855 56.4694754855943 region-1 stroke 6 7.92E-05 1.296418261 rs2091113 56.4903424442287 region-1 stroke 6 7.72E-05 1.289813486 rs10947863 57.4366623623595 all mi 6 6.10E-05 0.795591396 rs16882270 75.5976642418861 region-3 complications 6 7.44E-05 0.411494253 rs7746960 75.7752397459103 region-3 complications 6 6.46E-05 0.744928044 rs10485136 77.1251918947639 region-1 albu 6 8.36E-05 1.214443922 rs7452656 77.3115229043897 region-1 complications 6 7.14E-05 1.37307989 rs6914118 78.1632273843099 region-3 mi 6 7.55E-08 0.3331923 rs4710333 80.3206067411275 peal mi 6 1.61 E-04 0.73863963 rs3846820 80.3410997788468 all mi 6 8.80E-05 0.734795937 rs3846820 80.3410997788468 peal mi 6 1.38E-04 0.734795937 rs3914604 80.3444602060846 peal mi 6 1.48E-04 0.736890202 rs9346035 80.3447583996159 peal mi 6 1.85E-04 0.74053729 rs9363771 80.3451538389402 peal mi 6 1.50E-04 0.736268191 rs1924664 80.3759835798957 all mi 6 9.04E-05 0.735110607 rs1924664 80.3759835798957 peal mi 6 1.38E-04 0.735110607 rs2261485 80.4731123551613 peal mi 6 4.22E-04 0.75790935 rs2260393 80.4761987994386 peal mi 6 4.49E-04 0.759009465 rs2452463 80.4874970658481 peal mi 6 3.43E-04 0.754520796 rs2814689 80.4883775236091 peal mi 6 3.50E-04 0.754844525 rs 11754490 81.4904925961631 region-3 complications 6 5.55E-05 0.268179713 rs16896055 81.4948964990057 region-3 complications 6 3.42E-06 0.226305045

Page 25 Table LxIs

rs2350516 81.5443647479512 region-3 complications 6 9.97E-05 0.450784593 rs9354349 81.9105104920512 peal mi 6 4.05E-04 1.661834748 rs9354486 82.272072368065 all albu 6 9.95E-05 0.769258856 rs9354486 82.272072368065 peal albu 6 1.05E-04 0.769258856 rs1947417 82.3299711412996 peal albu 6 4.51 E-04 0.705189634 rs9360456 84.152341275518 all stroke 6 2.68E-05 1.47272791 rs12173424 84.1655093254241 all stroke 6 2.57E-05 1.402609506 rs9342838 84.1756153740358 all stroke 6 2.57E-05 1.402609506 rs535902 87.0019032310443 all stroke 6 3.13E-05 1.426109937 rs9443027 87.5546480589363 peal complications 6 4.76E-04 0.744322327 rs9360790 87.6085229982337 all mi 6 1.59E-07 0.087719673 rs9360790 87.6085229982337 peal mi 6 3.19E-05 0.087719673 rs9360790 87.6085229982337 all stroke 6 2.08E-04 0.112137487 rs9360790 87.6085229982337 region-1 mi 6 2.59E-04 0.065041186 rs12213227 88.1263900803211 peal stroke 6 3.90E-04 1.395322141 rs17792496 88.1739222473627 all stroke 6 6.09E-05 1.767854122 rs17792496 88.1739222473627 peal stroke 6 1.29E-04 1.767854122 rs1578656 90.2665724716918 region-1 mi 6 6.98E-05 1.404494888 rs7765427 91.2001534471384 peal complications 6 2.97E-04 1.363651996 rs9362068 92.3497160109454 all mi 6 9.76E-05 1.230703934 rs619192 97.6013906670699 peal complications 6 4.24E-04 0.781197599 rs1923083 98.0774053258471 region-3 complications 6 8.71 E-05 0.630106572 rs1368761 98.6157181271585 peal stroke 6 2.92E-04 2.207976545 rs4235842 98.8347634659871 all complications 6 5.50E-05 0.772215397 rs4235842 98.8347634659871 peal complications 6 1.33E-04 0.772215397 rs9345112 98.8560663699944 all complications 6 2.83E-05 0.75445856 rs9345112 98.8560663699944 peal complications 6 2.97E-05 0.75445856 rs4235846 98.8841257773463 all complications 6 4.00E-05 1.41694382 rs4235846 98.8841257773463 peal complications 6 4.71 E-05 1.41694382 rs12530533 100.139863954283 peal mi 7 4.02E-04 0.347330687 rs6465386 105.27764712224 region-1 stroke 7 3.83E-05 1.287886854 rs726820 106.127949930434 peal albu 7 4.00E-04 1.421642764 rs17251278 106.378764097723 region-1 complications 7 2.46E-05 0.664427255 rs17251278 106.378764097723 region-1 albu 7 1.75E-04 0.67673358 rs17251278 106.378764097723 all complications 7 4.73E-04 0.747139029 rs17600042 108.716888412564 region-1 albu 7 2.52E-06 0.375446338 rs17600042 108.716888412564 all complications 7 3.22E-06 0.512319778 rs17600042 108.716888412564 peal complications 7 4.65E-06 0.512319778 rs17600042 108.716888412564 all albu 7 1.91 E-05 0.502928128 rs17600042 108.716888412564 peal albu 7 2.64E-05 0.502928128 rs17600042 108.716888412564 region-1 complications 7 9.71 E-05 0.513819986 rs836474 11.1631299825025 peal stroke 7 3.10E-04 2.315506562 rs6959558 11.2874804791148 all stroke 7 8.60E-05 1.448168751 rs12539689 12.5482225425386 all stroke 7 2.17E-05 1.866309662 rs12539689 12.5482225425386 peal stroke 7 4.40E-05 1.866309662 rs17154998 120.63510375659 all mi 7 4.51 E-08 0.030862807 rs17154998 120.63510375659 all stroke 7 1.32E-04 0.059658875 rs17154998 120.63510375659 region-1 mi 7 1.55E-04 0 rs17154998 120.63510375659 region-3 mi 7 2.74E-04 0.06501548 rs10259910 124.188540088814 all complications 7 2.00E-06 1.412098888 rs10259910 124.188540088814 peal complications 7 2.49E-06 1.412098888

Paαe 26 Table 1.xls

rs10259910 124.188540088814 region-1 complications 7 1.53E-05 1.444417394 rs727164 124.196926770024 all complications 7 3.36E-06 1.400373433 rs727164 124.196926770024 peal complications 7 4.51 E-06 1.400373433 rs727164 124.196926770024 region-1 complications 7 1.65E-05 1.444417476 rs2193257 124.202313061697 all complications 7 1.06E-05 1.349638113 rs2193257 124.202313061697 peal complications 7 1.28E-05 1.349638113 rs2193257 124.202313061697 region-1 complications 7 1.11 E-04 1.358219321 rs2158050 124.210833120016 all complications 7 6.63E-06 1.358792128 rs2158050 124.210833120016 peal complications 7 7.67E-06 1.358792128 rs2158050 124.210833120016 region-1 complications 7 9.29E-05 1.361864691 rs6966339 124.213913297644 all complications 7 6.11 E-06 1.360457429 rs6966339 124.213913297644 peal complications 7 7.07E-06 1.360457429 rs6966339 124.213913297644 region-1 complications 7 9.29E-05 1.361864691 rs2699749 124.480695204812 all mi 7 8.80E-08 0.059867059 rs2699749 124.480695204812 region-1 mi 7 5.70E-05 0 rs2699749 124.480695204812 all stroke 7 9.07E-05 0.057082606 rs2699749 124.480695204812 peal mi 7 9.89E-05 0.059867059 rs2699749 124.480695204812 region-3 complications 7 4.77E-04 0.31023622 rs7779004 124.674450167222 all mi 7 4.34E-06 0.178235908 rs7779004 124.674450167222 peal mi 7 5.61 E-05 0.178235908 rs7779004 124.674450167222 region-1 mi 7 2.93E-04 0.06490939 rs9770283 127.073035605745 region-1 mi 7 4.25E-05 1.468914507 rs3779258 127.570773396173 peal complications 7 3.70E-04 1.538281551 rs11982195 13.3367858504489 all stroke 7 8.56E-05 1.21149506 rs11982195 13.3367858504489 region-1 stroke 7 2.25E-04 1.207092846 rs34266279 130.850771392923 peal complications 7 4.34E-04 1.702264168 rs4731517 131.642814292427 peal stroke 7 1.87E-04 1.588940706 rs3734974 131.646757301998 peal stroke 7 1.72E-04 1.593689812 rs2971772 135.374598586329 region-1 albu 7 6.90E-05 0.567373932 rs1558993 138.292232279372 region-3 mi 7 2.86E-07 0.475325701 rs1558993 138.292232279372 all mi 7 3.53E-04 0.796411677 rs6946578 138.292327895878 region-3 mi 7 2.86E-07 0.475325701 rs6946578 138.292327895878 all mi 7 2.03E-04 0.791048161 rs6957963 138.29308755253 region-3 mi 7 1.58E-06 0.501915709 rs6957963 138.29308755253 all mi 7 3.89E-04 0.801864543 rs10954447 138.293660262428 region-3 mi 7 1.29E-06 0.497625831 rs10954447 138.293660262428 all mi 7 4.23E-04 0.801413186 rs7801290 138.293810940853 region-3 mi 7 1.29E-06 0.497625831 rs7801566 138.293865013636 region-3 mi 7 9.12E-07 0.487937925 rs7801566 138.293865013636 all mi 7 4.69E-04 0.799257017 rs17167808 138.300969649723 region-3 mi 7 7.45E-06 0.528503456 rs7811948 138.303646911883 region-3 mi 7 6.02E-06 0.522267206 rs6967329 138.307014920869 region-3 mi 7 4.93E-05 0.519460416 rs4732026 138.313067115969 region-3 mi 7 5.01 E-05 0.528181165 rs10488464 138.751744862555 region-3 mi 7 2.54E-06 3.972972973 rs2348914 141.14838808261 peal albu 7 4.42E-04 1.42031759 rs7807871 142.543957387292 peal albu 7 2.86E-04 1.313056299 rs2350786 142.552293430087 peal albu 7 3.90E-04 1.307341189

γS7780181 142.589032586188 all albu 7 5.42E-05 0.817321423

γS17506977 142.596631761543 all albu 7 8.33E-05 0.813289689 rs6956284 151.062258495857 region-1 mi 7 6.34E-05 0.700889064

Paqe 27 Table 1.xls

rs6956284 151.062258495857 all complications 7 1.19E-04 0.766516725 rs6956284 151.062258495857 all mi 7 1.63E-04 0.760110544 rs6956284 151.062258495857 peal complications 7 1.67E-04 0.766516725 rs2960744 151.077317073538 peal complications 7 2.82E-04 0.775913817 rs6955265 151.078181412071 peal complications 7 3.97E-04 0.782602836 rs6963627 157.321328699488 region-1 stroke 7 9.94E-05 0.616498293 rs6963627 157.321328699488 all stroke 7 4.42E-04 0.717824867 rs6963627 157.321328699488 peal stroke 7 4.72E-04 0.717824867 rs1543265 158.512296715838 region-1 mi 7 1.33E-05 1.281445138 rs2882606 16.33807704133 all complications 7 8.98E-05 1.256695212 rs10952491 172.119706772478 all stroke 7 8.71 E-05 1.051515152 rs10952491 172.119706772478 region-1 stroke 7 1.56E-04 1.111588649 rs10263381 18.1388999515703 region-3 albu 7 2.64E-05 1.344895449 rs10263522 18.139081279427 region-3 albu 7 3.84E-05 1.319489334 rs4716619 180.479139850705 region-3 albu 7 2.68E-05 0.598488067 rs4716626 180.48394921998 region-3 albu 7 9.23E-05 0.624039092 rs10272911 19.965566558621 all stroke 7 8.19E-05 1.293949159 rs17168936 24.0487610308409 all mi 7 2.21 E-05 0.38862074 rs17168936 24.0487610308409 peal mi 7 5.45E-05 0.38862074 rs17168936 24.0487610308409 region-1 mi 7 6.68E-05 0.253861386 rs1295142 25.2442810614541 region-1 albu 7 6.81 E-05 1.611429611 rs1295139 25.2466210715142 region-1 albu 7 9.58E-05 1.593415836 rs1295135 25.2526763441112 region-1 albu 7 6.61 E-05 1.615573136 rs1295133 25.2585178566945 region-1 albu 7 9.02E-05 1.602797139 rs847386 26.5113255709458 region-3 albu 7 8.96E-05 0.91765873 rs12154706 30.2387828438772 all complications 7 7.16E-05 0.762873599 rs12154706 30.2387828438772 peal complications 7 9.02E-05 0.762873599 rs2334063 4.38742526504109 peal albu 7 3.96E-04 0.775561572 rs1009253 43.7466739481423 region-3 stroke 7 4.74E-05 1.477111541 rs7790213 44.2423285900829 region-1 complications 7 8.81 E-05 1.204900248 rs886750 45.9263600028343 peal stroke 7 4.66E-04 1.39483795 rs221153 46.1700294945313 region-1 stroke 7 3.39E-05 1.410727636 rs221193 46.2077851669459 region-1 stroke 7 6.49E-05 1.387035592 rs10248275 5.28431449966023 region-1 albu 7 3.12E-05 2.168872003 rs10248275 5.28431449966023 region-1 complications 7 3.83E-05 2.350290698 rs10248275 5.28431449966023 all albu 7 1.62E-04 1.81672874 rs10248275 5.28431449966023 peal albu 7 2.00E-04 1.81672874 rs10248275 5.28431449966023 all complications 7 2.92E-04 1.924852741 rs10248275 5.28431449966023 peal complications 7 3.67E-04 1.924852741 rs10281059 52.2356947282253 all mi 7 1.82E-06 0.072933291 rs10281059 52.2356947282253 peal mi 7 2.61 E-04 0.072933291 rs17171395 58.981812861339 peal complications 7 4.31 E-04 2.198158051 rs35489914 62.7798389964423 region-1 stroke 7 5.22E-05 1.870364312 rs10233697 66.2765284478962 region-1 albu 7 7.24E-05 1.476855062 rs10233697 66.2765284478962 all albu 7 2.65E-04 1.338753834 rs10233697 66.2765284478962 peal albu 7 2.80E-04 1.338753834 rs10281917 66.3341675819428 region-1 albu 7 4.54E-05 1.504143823 rs13240269 66.4304246806755 region-1 albu 7 8.41 E-05 1.47188439 rs13240269 66.4304246806755 all albu 7 3.68E-04 1.330065359 rs13240269 66.4304246806755 peal albu 7 3.87E-04 1.330065359 rs17654227 66.434978663381 region-1 albu 7 8.95E-05 1.473193473

Page 28 Table LxIs

rs10234057 66.5103218835546 peal albu 7 4.52E-04 1 324426329 rs1468405 66.6782547794138 region-1 stroke 7 5.54E-06 1.405813953 rs2528398 66.6850905370673 region-1 stroke 7 4.63E-06 1.410714286 rs1553009 68.8713409344715 region-1 stroke 7 3.72E-06 1.20465594 rs1553009 68.8713409344715 all stroke 7 2.36E-05 1.210157529 rs1569255 74.9284023946598 region-3 mi 7 4.43E-05 1.440757369 rs1569256 74.9285693162195 region-3 mi 7 4.43E-05 1.440757369 rs2163634 74.9292935860377 region-3 mi 7 4.43E-05 1.440757369 rs2163635 74.929317634059 region-3 mi 7 7.09E-05 1.432293056 rs2110290 75.4478241944404 peal mi 7 2.19E-04 0.737307951 rs12671550 75.4479870002941 peal mi 7 3.66E-04 0.74350282 rs10499782 77.4616432706253 region-3 stroke 7 6.20E-07 5.676432572 rs10259713 77.469998293723 region-3 stroke 7 5.85E-07 5.528571429 rs7795090 78.6083209770022 all mi 7 3.29E-06 0.076156902 rs7795090 78.6083209770022 all stroke 7 1.93E-04 0 rs7795090 78.6083209770022 peal mi 7 3.36E-04 0.076156902 rs13230952 81.1209946180491 region-3 complications 7 7.82E-05 0.570688444 rs13231053 81.1210501856444 region-3 complications 7 7.50E-05 0.561181435 rs6957385 81.1213570897475 region-3 complications 7 7.50E-05 0.572649573 rs321974 91.3625006907635 region-3 complications 7 8.58E-05 3.309672063 rs12533988 98.3879305951896 all stroke 7 5.61 E-05 1.46747566 rs12533988 98.3879305951896 region-1 stroke 7 1.03E-04 1.6383027 rs12533988 98.3879305951896 peal stroke 7 1.53E-04 1.46747566 rs10235865 98.3883438646555 all stroke 7 4.72E-05 1.448115643 rs10235865 98.3883438646555 peal stroke 7 5.62E-05 1.448115643 rs10235865 98.3883438646555 region-1 stroke 7 3.59E-04 1.522384544 rs2718295 98.3939673359152 all stroke 7 6.13E-05 1.487887648 rs2718295 98.3939673359152 region-1 stroke 7 6.44E-05 1.664290429 rs2718295 98.3939673359152 peal stroke 7 8.08E-05 1.487887648 rs10487028 98.3940381675499 all stroke 7 2.55E-05 1.465001339 rs10487028 98.3940381675499 peal stroke 7 3.08E-05 1.465001339 rs10487028 98.3940381675499 region-1 stroke 7 1.92E-04 1.550946458 rs2538906 98.3942341011007 peal stroke 7 1.59E-04 1.452763173 rs7786701 98.3942957602935 all stroke 7 4.27E-05 1.449562671 rs7786701 98.3942957602935 peal stroke 7 5.02E-05 1.449562671 rs7786701 98.3942957602935 region-1 stroke 7 3.22E-04 1.527280417 rs7786701 98.3942957602935 all complications 7 4.86E-04 1.274866717 rs3948632 98.3943296473706 peal stroke 7 1.69E-04 1.450383038 rs10487029 98.3947008764778 all stroke 7 3.22E-05 1.457384574 rs10487029 98.3947008764778 peal stroke 7 3.81 E-05 1.457384574 rs10487029 98.3947008764778 region-1 stroke 7 1 -52E-04 1.56120022 rs6465147 98.3955100896861 all stroke 7 2.87E-05 1.462227841 rs6465147 98.3955100896861 peal stroke 7 3.62E-05 1.462227841 rs6465147 98.3955100896861 region-1 stroke 7 2.00E-04 1.55 rs4876153 1.09177636920665 region-3 stroke 8 6.53E-05 1.706973595 rs4286971 1.62717504753291 all mi 8 6.87E-05 1.297547989 rs2046370 100.551337811444 all stroke 8 2.33E-05 1.611923114 rs2046370 100.551337811444 peal stroke 8 2.67E-05 1.611923114 rs4406411 101.796441062234 all complications 8 7.71 E-05 1.304463152 rs4406411 101.796441062234 peal complications 8 8.21 E-05 1.304463152 rs10105587 101.798093746637 all complications 8 8.71 E-05 1.302582369

Page 29 Table LxIs

rs10105587 101.798093746637 peal complications 8 9.23E-05 1.302582369 rs4130030 101.798897882491 peal complications 8 1.11E-04 1.300343268 rs13273013 101.801360842752 all complications 8 5.70E-05 1.311305732 rs13273013 101.801360842752 peal complications 8 6.07E-05 1.311305732 rs10504841 102.002630173036 all mi 8 1.07E-06 0.462540717 rs10504841 102.002630173036 peal mi 8 1.85E-06 0.462540717 rs10504841 102.002630173036 region-1 mi 8 4.36E-04 0.501952392 rs10504841 102.002630173036 region-3 complications 8 4.78E-04 0.461029854 rs10956801 102.657540871355 all mi 8 1.27E-05 0.232126677 rs10956801 102.657540871355 peal mi 8 6.16E-05 0.232126677 rs16915836 104.797911870084 peal mi 8 4.04E-04 0.615236208 rs7011618 105.493056154636 peal mi 8 1.28E-04 1.328672087 rs6998580 105.493162320939 peal mi 8 1.46E-04 1.325447154 rs7842637 114.827882341964 all albu 8 3.15E-05 1.929001371 rs7842637 114.827882341964 all mi 8 7.60E-05 0.411566204 rs7842637 114.827882341964 peal albu 8 7.65E-05 1.929001371 rs7842637 114.827882341964 peal mi 8 2.15E-04 0.411566204 rs16867595 116.178626176304 region-1 albu 8 1.60E-05 0.927994843 rs10094168 116.179273433375 regioπ-1 albu 8 1.02E-05 0.917441533 rs930148 116.180067247051 region-1 albu 8 2.68E-05 0.938439659 rs7014251 116.188048561953 region-1 albu 8 5.94E-05 0.942075358 rs17477680 116.262799072927 all mi 8 1.50E-05 1.654940396 rs17477680 116.262799072927 peal mi 8 2.28E-05 1.654940396 rs17477680 116.262799072927 region-1 mi 8 4.96E-05 1.746296197 rs4734805 117.549345185631 peal stroke 8 2.34E-04 1.48770266 rs722740 124.520128017978 region-1 mi 8 6.31 E-05 0.679764048 rs10095930 124.523683925495 region-1 mi 8 7.63E-05 0.686545221 rs4876626 124.531039303745 region-1 mi 8 6.57E-05 0.686766656 rs2316305 124.54650614511 region-1 mi 8 9.84E-05 0.673584906 rs7004124 124.562046286306 region-1 mi 8 8.38E-05 0.677234826 rs9643109 124.563314315654 region-1 mi 8 6.20E-05 0.675053918 rs2316310 124.563526712013 region-1 mi 8 4.98E-05 0.671818835 rs1540899 124.565765242658 region-1 mi 8 4.56E-05 0.670536906 rs16889712 124.939014038953 all albu 8 2.60E-05 1.498528704 rs16889712 124.939014038953 peal albu 8 7.14E-05 1.498528704 rs16889748 124.948120244253 all albu 8 3.58E-05 1.489100933 rs16889748 124.948120244253 peal albu 8 9.41 E-05 1.489100933 rs17750253 125.251335958555 all mi 8 1.04E-05 0.353128314 rs17750253 125.251335958555 peal mi 8 3.35E-05 0.353128314 rs4870752 126.174324529247 peal mi 8 2.39E-04 1.350348182 rs16895701 127.606275976124 peal stroke 8 4.57E-04 2.439891267 rs7018271 128.357314177525 all stroke 8 5.08E-05 1.382822061 rs1464611 128.576386086053 region-3 albu 8 4.85E-05 1.693368022 rs1464611 128.576386086053 all albu 8 1.48E-04 1.267488311 rs7830506 132.766699710671 region-1 stroke 8 9.13E-05 0.648260496 rs10755926 134.764600700016 all complications 8 9.78E-05 1.229688819 rs11780672 14.5629182256109 region-3 albu 8 8.94E-05 0.53801465 rs4733804 140.482724575722 peal mi 8 2.99E-04 0.733979836 rs12156376 141.536877524742 all mi 8 5.68E-05 0.762468109 rs12156376 141.536877524742 peal mi 8 4.42E-04 0.762468109 rs6996688 144.167825115179 peal stroke 8 3.76E-04 1.45160257

Paαe 30 Table LxIs

rs1836630 144.170504840378 peal stroke 8 2.01 E-04 1.475955926 rs10104127 144.172001198929 peal stroke 8 3.44E-04 1.457023509

γS10108431 144.175454828766 peal stroke 8 2.55E-04 1.467340337 rs1849692 154.87111490054 peal stroke 8 4.52E-04 1.598817423 rs13279285 154.928599026287 peal stroke 8 3.69E-04 1.592506075 rs17634562 154.968403933218 all stroke 8 9.16E-05 1.607810321 rs17634562 154.968403933218 peal stroke 8 1.84E-04 1.607810321 rs16908507 156.510503955075 region-1 stroke 8 7.72E-05 1.464739158 rs4634696 156.532278855634 region-1 stroke 8 4.61 E-05 1.45003371 rs4736185 158.857611262636 region-3 complications 8 9.42E-05 0.650804486 rs7004769 16.015250949909 peal stroke 8 3.24E-04 1.446402538 rs11784552 16.1054135429836 all stroke 8 6.13E-06 1.485444195 rs11784552 16.1054135429836 peal stroke 8 1.15E-04 1.485444195 rs10091799 16.1077454175097 all stroke 8 9.47E-05 1.419292119 rs10091799 16.1077454175097 peal stroke 8 3.25E-04 1.419292119 rs2975272 167.904700632942 peal complications 8 1.28E-04 0.684345384 rs17121574 26.4539484348607 region-1 albu 8 2.10E-05 3.220551378 rs12541202 27.6219441673702 peal stroke 8 3.90E-04 2.254697712 rs17094449 27.6438291827536 peal stroke 8 4.30E-04 2.238153222 rs7828061 28.9629642214454 region-1 stroke 8 2.17E-05 0.993129811 rs13254344 3.04374950473293 region-1 stroke 8 4.59E-05 1.150793651 rs895696 3.04627920590978 region-1 stroke 8 3.85E-05 1.154792988 rs895695 3.04669493330121 region-1 stroke 8 4.71 E-05 1.160807779 rs17066499 3.47717856848939 peal stroke 8 2.40E-04 1.69047619 rs5026429 3.48320661566512 peal stroke 8 2.01 E-04 1.629712598 rs9325744 30.8311099067278 region-1 albu 8 2.29E-05 1.608531583 rs9325744 30.8311099067278 all albu 8 1.65E-04 1.425456298 rs9325744 30.8311099067278 peal albu 8 1.77E-04 1.425456298 rs9325744 30.8311099067278 region-1 complications 8 3.97E-04 1.478213946 rs17590021 35.9352661405026 all albu 8 8.53E-05 0.88315069 rs17091519 39.0112973580296 region-3 complications 8 5.15E-05 0.459240475 rs2554622 4.19143772106728 all mi 8 9.86E-05 0.739266419 rs2554622 4.19143772106728 peal mi 8 1.06E-04 0.739266419 rs2554621 4.19152502381948 peal mi 8 1.72E-04 0.747598849 rs2627531 4.19162064111951 peal mi 8 1.34E-04 0.742889918 rs17832528 51.3059095661174 region-3 stroke 8 9.14E-05 1.361410602 rs2614062 55.1936706202029 all complications 8 7.46E-05 1.210339029 rs17072025 6.07216531642842 peal mi 8 4.11 E-04 1.413157911 rs7838821 6.07406426925523 all complications 8 5.64E-06 2.627815217 rs7838821 6.07406426925523 peal complications 8 1.27E-05 2.627815217 rs7838821 6.07406426925523 region-1 complications 8 7.42E-05 2.730395874 rs13253981 60.3028784275937 region-1 stroke 8 2.87E-05 1.59194282 rs16880153 60.4549618477484 region-3 albu 8 6.36E-06 2.609412114 rs16880153 60.4549618477484 region-3 complications 8 1.25E-04 3.586098729 rs4236721 60.4610151372077 peal mi 8 4.36E-04 0.271110558 rs490767 61.7679949486444 peal complications 8 1.83E-04 0.753283691 rs17303597 61.8475423692569 peal mi 8 4.99E-04 1.309611487 rs210664 64.3448570289126 region-1 complications 8 4.90E-05 1.397211728 rs210664 64.3448570289126 all complications 8 1.20E-04 1.331662097 rs210664 64.3448570289126 peal complications 8 2.57E-04 1.331662097 rs1674241 66.3592037820424 peal complications 8 2.18E-04 0.651570932

Page 31 Table 1.xls

rs2926110 66.3639289124503 all complications 8 8.36E-05 0.630012484 rs2926110 66.3639289124503 peal complications 8 1.18E-04 0.630012484 rs2926110 66.3639289124503 all mi 8 1.68E-04 0.563919822 rs2926110 66.3639289124503 peal mi 8 2.41 E-04 0.563919822 rs2956830 66.3692975255787 peal complications 8 1.84E-04 0.653336423 rs2956830 66.3692975255787 peal mi 8 4.39E-04 0.601313883 rs2926095 66.3941448186756 peal complications 8 3.00E-04 0.660395828 rs10081463 66.4164504676552 peal complications 8 4.33E-04 0.668713564 rs10081428 66.4183756598315 peal complications 8 2.38E-04 0.656443464 rs10081556 66.4185108137285 peal complications 8 1.72E-04 0.650671412 rs13263794 66.4186947731993 peal complications 8 3.12E-04 0.66121572 rs7843358 66.4240333521283 all complications 8 5.33E-05 0.621559491 rs7843358 66.4240333521283 peal complications 8 6.48E-05 0.621559491 rs7843358 66.4240333521283 all mi 8 1.28E-04 0.555918098 rs7843358 66.4240333521283 peal mi 8 1.59E-04. 0.555918098 rs11778828 66.4252917850798 peal complications 8 2.07E-04 0.65234858 rs10106681 73.6414742154385 all mi 8 9.86E-05 1.317075495 rs10106681 73.6414742154385 peal mi 8 3.13E-04 1.317075495 rs16923447 75.2650884103122 region-3 mi 8 3.71 E-06 0.553636364 rs4541896 75.3256947724225 region-3 mi 8 3.41 E-05 0.594405594 rs6999409 77.6971607586712 region-3 complications 8 2.71 E-05 0.530443756 rs16923831 77.6999540355546 region-3 complications 8 2.87E-05 0.535255089 rs4147445 79.3772871977246 region-3 mi 8 4.51 E-05 0.545882162 rs2936535 8.48492744170879 region-1 albu 8 8.38E-05 0.704051425 rs2936535 8.48492744170879 all complications 8 1.28E-04 0.759480142 rs2936535 8.48492744170879 all albu 8 2.11 E-04 0.762657968 rs2936535 8.48492744170879 region-1 complications 8 2.74E-04 0.746897055 rs2912020 8.48599079381404 region-1 albu 8 8.42E-05 0.706478034 rs2912020 8.48599079381404 all complications 8 9.78E-05 . 0.760180567 rs2912020 8.48599079381404 region-1 complications 8 2.26E-04 0.743233805 rs2912020 8.48599079381404 all albu 8 2.66E-04 0.771013638 rs1541749 8.49959086405198 region-1 albu 8 9.40E-05 0.704138857 rs1541749 8.49959086405198 all complications 8 2.22E-04 0.769674986 rs1541749 8.49959086405198 all albu 8 2.90E-04 0.771089285 rs17078168 8.56125174027017 all albu 8 5.71 E-05 0.571816601 rs17078168 8.56125174027017 peal albu 8 6.98E-05 0.571816601 rs17078168 8.56125174027017 region-1 albu 8 2.53E-04 0.529385058 rs6991180 82.3833099687312 peal mi 8 3.05E-04 0.410809983 rs10504444 87.5299492746081 peal stroke 8 3.53E-04 0.692406369 rs2035930 89.1149430717877 peal mi 8 3.51 E-04 1.726580825 rs7839694 89.5627459558854 all stroke 8 4.08E-05 3.267743866 rs7839694 89.5627459558854 peal stroke 8 1.02E-04 3.267743866 rs2738128 9.40223456960454 region-3 mi 8 4.14E-07 16.69902913 rs4737321 90.242551606464 region-1 complications 8 9.80E-05 0.540384756 rs4737321 90.242551606464 region-1 mi 8 1.24E-04 0.406213441 rs5008854 90.4863502487223 region-1 stroke 8 9.68E-05 1.22094431 rs17358302 94.204417997792 peal mi 8 3.93E-04 1.335456282 rs6998702 94.2505449500385 all mi 8 3.03E-05 0.661381615 rs6998702 94.2505449500385 peal mi 8 6.16E-05 0.661381615 rs7017087 94.2505568316136 all mi 8 2.14E-05 0.657610403 rs7017087 94.2505568316136 peal mi 8 4.92E-05 0.657610403

Page 32 Table LxIs

rs16905587 94.4914622104813 peal mi 8 2.23E-04 0.506277522 rs730561 98.7381608885787 all mi 8 3.72E-07 0 rs730561 98.7381608885787 region-3 mi 8 3.14E-04 0 rs12346176 0.926957962051252 peal albu 9 4.85E-04 0.771103618 rs2265800 101.178348780719 region-1 mi 9 5.37E-05 1.267608696 rs2265800 101.178348780719 all mi 9 1.06E-04 1.248377172 rs9409699 101.182432405419 region-1 mi 9 3.21 E-05 1.238519375 rs9409699 101.182432405419 all mi 9 4.73E-05 1.232253974 rs4744280 101.184650635654 all mi 9 3.47E-05 1.258318002 rs4744280 101.184650635654 region-1 mi 9 3.50E-05 1.259680857 rs7859190 101.197396236585 region-1 mi 9 5.72E-05 1.230653295 rs7859190 101.197396236585 all mi 9 8.13E-05 1.228105906 rs7047415 102.496925050084 all albu 9 4.17E-05 1.584644249 rs7047415 102.496925050084 peal albu 9 5.83E-05 1.584644249 rs7047415 102.496925050084 region-1 albu 9 1.27E-04 1.667716849 rs7029315 102.499292509778 all albu 9 6.39E-05 1.556087824 rs7029315 102.499292509778 peal albu 9 1.09E-04 1.556087824 rs7029315 102.499292509778 region-1 albu 9 3.62E-04 1.610888843 rs16910240 102.499333039659 all albu 9 4.17E-05 1.584644249 rs16910240 102.499333039659 peal albu 9 5.83E-05 1.584644249 rs16910240 102.499333039659 region-1 albu 9 1.62E-04 1.65255561 rs10989294 102.708421547234 all complications 9 7.85E-05 0.633071997 rs10989294 102.708421547234 peal complications 9 1.06E-04 0.633071997 rs10114374 102.772979857112 peal albu 9 4.73E-04 1.299339728 rs6477872 103.327417044315 region-1 albu 9 8.44E-05 1.333774134 rs6477872 103.327417044315 all albu 9 3.44E-04 1.287189046 rs6477872 103.327417044315 peal albu 9 4.14E-04 1.287189046 rs914993 104.528570086782 all mi 9 2.20E-07 0.034051407 rs914993 104.528570086782 region-1 mi 9 1.25E-04 0 rs914993 104.528570086782 all stroke 9 3.14E-04 0.066022408 rs16919323 105.416308065738 peal complications 9 3.81 E-04 2.01534757 rs4355836 107.737354105966 region-3 complications 9 9.32E-06 0.523632006 rs1924022 107.759099329612 region-3 complications 9 2.30E-06 0.506232687 rs12554104 108.110783000542 region-3 albu 9 2.20E-05 0.443342488 rs2740485 110.556832561452 peal albu 9 2.30E-04 1.471626506 rs1332297 116.865107859273 region-1 mi 9 5.34E-05 1.601375789 rs10115131 116.906114376605 all complications 9 9.54E-05 0.783483633 rs10115131 116.906114376605 region-1 complications 9 1.27E-04 0.757368717 rs10115131 116.906114376605 all albu 9 4.88E-04 0.790488543 rs1339881 117.013613138686 region-3 mi 9 9.69E-05 1.567271088 rs10116332 117.034531122534 region-1 mi 9 3.36E-05 1.273480777 rs3793561 117.175585998867 region-3 complications 9 4.71 E-05 0.63003359 rs10979779 117.179977940103 region-3 complications 9 1.57E-05 1.652480468 rs7019068 117.207555528244 region-1 complications 9 6.19E-05 0.664529514 rs7019068 117.207555528244 region-1 albu 9 4.80E-04 0.681315185 rs9886729 117.40030611956 region-3 mi 9 7.10E-05 1.711063373 rs11999319 117.41841514413 region-3 stroke 9 8.91 E-05 1.319156293 rs2251680 122.071445440235 all mi 9 7.02E-05 0.806169659 rs13287677 122.664064754007 peal mi 9 2.80E-04 0.406347459 rs10982428 122.986157040108 all mi 9 2.68E-05 0.392270789 rs10982428 122.986157040108 peal mi 9 7.64E-05 0.392270789

Paαe 33 Table 1.xls

rs7874294 127.688501463809 region-1 complications 9 8.51 E-05 0.79519647 rs7874294 127.688501463809 all complications 9 1.44E-04 0.837342073 rs10760419 137.769716457788 all stroke 9 7.45E-05 1.316949842 rs11243840 144.722212113561 all stroke 9 8.56E-05 1.37176249 rs4498679 144.787069421833 all stroke 9 9.74E-06 1.381100056 rs10901198 144.813759609274 all stroke 9 7.56E-05 1.385958619 rs7872232 15.2496482237552 region-3 albu 9 7.57E-05 1.847589532 rs4842243 157.838327290813 peal mi 9 3.69E-04 0.762744035 rs4842244 157.83848614308 all complications 9 3.15E-05 0.751582905 rs4842244 157.83848614308 region-1 complications 9 4.56E-05 0.708668932 rs4842244 157.83848614308 all mi 9 6.95E-05 0.724462993 rs4842244 157.83848614308 peal complications 9 2.04E-04 0.751582905 rs4842244 157.83848614308 peal mi 9 3.11 E-04 0.724462993 rs10964178 33.7237971896415 peal complications 9 2.94E-04 1.290974608 rs1868727 41.4454539697308 all mi 9 2.29E-06 0.171484722 rs1868727 41.4454539697308 all stroke 9 1.19E-05 0 rs1868727 41.4454539697308 peal mi 9 4.26E-05 0.171484722 rs1868727 41.4454539697308 region-3 mi 9 2.30E-04 0.108614865 rs1812582 47.9530908048626 peal albu 9 2.17E-04 1.348019593 rs2013004 47.95318682523 all albu 9 3.62E-05 1.379345863 rs2013004 47.95318682523 peal albu 9 6.20E-05 1.379345863 rs2013004 47.95318682523 region-1 albu 9 2.87E-04 1.417151007 rs1340186 5.10534012741488 region-3 albu 9 7.51 E-05 0.537247706 rs10968561 51.1643836541205 all albu 9 8.26E-05 0.838118698 rs10968561 51.1643836541205 region-1 albu 9 4.82E-04 0.809888609 rs1821432 52.1693927753585 peal complications 9 3.66E-04 0.586410035 rs1028932 56.371222677157 region-1 albu 9 8.25E-05 1.287949609 rs10813889 56.7338511554219 peal complications 9 2.47E-04 0.688310297 rs4879628 56.7397507381807 peal complications 9 4.70E-04 0.700317512 rs10972788 59.197324615201 all mi 9 6.60E-05 1.948660179 rs10972788 59.197324615201 peal mi 9 8.97E-05 1.948660179 rs10972788 59.197324615201 region-1 mi 9 1.88E-04 2.081978799 rs11142029 65.8759279494375 region-1 stroke 9 1.93E-05 1.335736424 rs4310272 66.1269028860178 all mi 9 6.38E-05 1.452240048 rs4310272 66.1269028860178 peal mi 9 1.14E-04 1.452240048 rs11139946 83.4796350001865 all stroke 9 1.41 E-06 1.409478074 rs7035425 83.8231034311226 peal albu 9 3.36E-04 1.274338905 rs2251760 85.9975669594345 peal complications 9 2.31 E-04 1.338636254 rs2265423 86.0046950523388 peal complications 9 2.69E-04 1.337012726 rs4877934 87.019248656973 peal complications 9 3.66E-04 1.841400911 rs935466 87.0823333995532 peal complications 9 4.77E-04 0.789986737 rs7850197 89.6594212205413 all complications 9 8.19E-05 1.277601609 rs7850197 89.6594212205413 peal complications 9 3.27E-04 1.277601609 rs10746779 89.7199442900758 all complications 9 7.96E-06 1.289703692 rs10746779 89.7199442900758 peal complications 9 2.11 E-04 1.289703692 rs10746779 89.7199442900758 region-1 complications 9 4.34E-04 1.317895314 rs10120212 90.8250921237526 peal complications 9 3.54E-04 1.52664624 rs1887439 90.8401930467996 all complications 9 6.13E-05 1.537297043 rs1887439 90.8401930467996 peal complications 9 6.63E-05 1.537297043 rs11141918 91.8025846764062 all complications 9 6.00E-05 0.830258646 rs1443360 95.7183013115479 all mi 9 9.68E-05 1.247554955

Paqe 34 Table 1.xls

rs290254 96.9655623760329 all complications 9 2.30E-05 0.772491349 γS290254 96.9655623760329 peal complications 9 2.21 E-04 0.772491349 rs290253 96.965860595472 all complications 9 2.17E-05 0.775140318 rs290253 96.965860595472 peal complications 9 2.72E-04 0.775140318 rs158688 96.9705224983986 all complications 9 8.13E-05 0.755211885 rs158688 96.9705224983986 peal complications 9 8.57E-05 0.755211885 rs158687 96.9706107542708 peal complications 9 2.49E-04 0.76569377 rs10991736 97.2155762897914 peal mi 9 2.57E-04 1.490600521 rs6479352 99.0257782500242 peal complications 9 3.87E-04 0.77862973 rs4881336 1.3423199914286 all albu 10 7.99E-05 0.247196373 rs4881336 1.3423199914286 peal albu 10 2.62E-04 0.247196373 rs10824696 100.753415419158 peal complications 10 4.16E-04 1.410777834 rs7073811 103.919166551408 peal albu 10 3.29E-04 0.768148411 rs11193235 103.920822747051 peal albu 10 2.17E-04 0.764648375 rs1010860 104.563500460967 region-1 stroke 10 2.90E-05 1.765995439 rs10788380 105.816395440688 region-1 albu 10 5.72E-05 1.351958094 rs10904339 11.496043592784 all albu 10 7.88E-05 0.691887857 rs10904339 11.496043592784 peal albu 10 1.03E-04 0.691887857 rs11595123 11.5315766930176 peal complications 10 1.40E-04 0.737664317 rs17117789 110.541961949512 peal stroke 10 4.10E-04 1.687681549 rs7074555 110.544414271236 peal stroke 10 2.98E-04 1.689831718 rs10159959 111.4773347303 all mi 10 2.30E-07 0.034151082 rs10159959 111.4773347303 region-1 mi 10 2.54E-04 0 rs10159959 111.4773347303 all stroke 10 3.10E-04 0.065918123 rs10159959 111.4773347303 region-3 mi 10 3.73E-04 0.06749226 rs17094380 112.131619207498 region-1 stroke 10 7.52E-05 1.203151431 rs10881893 114.760707567513 region-1 albu 10 4.25E-05 1.218490226 γS1057848 115.588393167207 peal stroke 10 4.97E-04 1.377948994 rs10882052 115.606636787332 peal stroke 10 4.22E-04 1.38238362 rs11187808 116.595933091204 peal complications 10 3.69E-04 1.280377702 rs2025445 116.737405973706 all albu 10 3.45E-05 0.731664963 rs2025445 116.737405973706 all complications 10 1.41 E-04 0.776305833 rs2025445 116.737405973706 peal albu 10 1.87E-04 0.731664963 rs2105450 12.5716475903928 region-3 stroke 10 6.89E-05 1.657338308 rs11189836 121.270161802112 all mi 10 2.43E-08 0.029790019 rs11189836 121.270161802112 region-3 mi 10 9.82E-05 0.057943925 rs11189836 121.270161802112 region-1 mi 10 1.06E-04 0 rs11189836 121.270161802112 all stroke 10 3.13E-04 0.117171112 rs11189836 121.270161802112 peal mi 10 4.59E-04 0.029790019 rs17114146 124.326880612202 region-3 complications 10 9.10E-05 0.36209618 rs17114146 124.326880612202 region-3 mi 10 2.41 E-04 0.249201278 rs4918029 125.237896256412 peal complications 10 1.90E-04 0.727210246 rs10509870 127.539349248176 all complications 10 8.54E-05 0.633364457 rs10509870 127.539349248176 peal complications 10 1.22E-04 0.633364457 rs10509870 127.539349248176 region-1 complications 10 4.20E-04 0.634712268 rs1546240 127.540483373068 peal complications 10 3.29E-04 0.648950282 rs17124218 127.558593294484 peal complications 10 2.29E-04 0.607030303 rs7900353 127.814529008863 region-1 complications 10 9.78E-05 0.99669623 rs11195125 129.093876328681 region-1 complications 10 6.87E-05 1.928233938 rs11195125 129.093876328681 all complications 10 1.98E-04 1.693335269 rs11195125 129.093876328681 peal complications 10 2.37E-04 1.693335269

Page 35 Table 1.xls

rs6585304 134.112811120488 all complications 10 7.33E-05 0.503729706 rs6585304 134.112811120488 peal complications 10 1.21E-04 0.503729706 rs6585304 134.112811120488 all albu 10 4.72E-04 0.50584893 rs11197169 134.646583812192 all mi 10 3.22E-08 0.030885335 rs11197169 134.646583812192 region-1 mi 10 7.77E-05 0 rs11197169 134.646583812192 all stroke 10 1.07E-04 0.059450641 rs11197169 134.646583812192 region-3 mi 10 2.35E-04 0.063862928 rs11197169 134.646583812192 peal mi 10 4.89E-04 0.030885335 rs363314 137.17408288742 all stroke 10 7.03E-05 1.297209804 rs363314 137.17408288742 region-3 stroke 10 2.29E-04 1.529243484 rs375973 137.6660284067 region-1 albu 10 7.10E-05 0.71559633 rs375973 137.6660284067 all albu 10 4.69E-04 0.787057653 rs375973 137.6660284067 peal albu 10 4.79E-04 0.787057653 rs454266 137.67158558977 region-1 albu 10 8.41 E-05 0.71834031 rs454266 137.67158558977 all albu 10 4.87E-04 0.787973173 rs454266 137.67158558977 peal albu 10 4.98E-04 0.787973173 rs17099196 140.52080134453 peal mi 10 4.57E-04 1.630224701 rs17099199 140.528519654349 peal mi 10 1.53E-04 1.745386449 rs3781500 140.652731189461 peal mi 10 4.29E-04 1.629444141 rs4445563 140.86054449054 peal mi 10 3.10E-04 1.646082949 rs2935720 143.136398450296 peal complications 10 4.72E-04 0.636233242 rs10510115 145.950309709798 all mi 10 8.95E-08 1.842745273 rs10510115 145.950309709798 peal mi 10 1.37E-07 1.842745273 rs10510115 145.950309709798 region-1 complications 10 1.25E-06 2.012716865 rs10510115 145.950309709798 region-1 mi 10 3.47E-06 1.892480934 rs10510115 145.950309709798 all complications 10 1.76E-05 1.708284611 rs10510115 145.950309709798 peal complications 10 2.11 E-05 1.708284611 rs7896663 145.96168321889 peal mi 10 1.09E-04 1.492553984 rs845083 147.608667701978 region-1 albu 10 4.50E-05 1.456994775 rs705149 147.616902683998 region-1 albu 10 8.71 E-05 1.473598108 rs7091802 147.997997157413 region-1 stroke 10 9.26E-05 0.787834101 rs6588759 148.328428499409 all mi 10 1.47E-05 1.34804003 rs6588759 148.328428499409 all complications 10 1.73E-05 1.383714571 rs6588759 148.328428499409 peal complications 10 1.89E-05 1.383714571 rs6588759 148.328428499409 peal mi 10 1.76E-04 1.34804003 rs6588759 148.328428499409 region-1 mi 10 3.37E-04 1.312839917 rs7067701 148.330573087854 all mi 10 5.48E-06 1.352035573 rs7067701 148.330573087854 all complications 10 1.23E-05 1.395667785 rs7067701 148.330573087854 peal complications 10 1.36E-05 1.395667785 rs7067701 148.330573087854 region-1 mi 10 9.53E-05 1.311404109 rs7067701 148.330573087854 peal mi 10 1.62E-04 1.352035573 rs908366 149.216036090974 peal complications 10 2.28E-04 1.30790355 rs1254947 149.239716912388 peal complications 10 3.03E-04 1.29528522 rs1254947 149.239716912388 peal albu 10 4.86E-04 1.273926114 rs10901545 153.597689568848 all stroke 10 2.21E-05 0.15304218 rs10901545 153.597689568848 all mi 10 4.65E-05 0.351856385 rs10901545 153.597689568848 peal mi 10 9.62E-05 0.351856385 rs10901545 153.597689568848 peal stroke 10 2.21 E-04 0.15304218 rs10901545 153.597689568848 region-1 mi 10 2.97E-04 0.246202532 rs10901545 153.597689568848 region-3 stroke 10 4.54E-04 0.068328803 rs7904011 156.21218752484 all complications 10 7.58E-05 0.720456586

Page 36 Table 1.xls

rs4750774 164.319437345938 all complications 10 3.18E-05 1.124927338 rs4750774 164.319437345938 region-1 complications 10 3.34E-04 1.099494919 rs11016947 164.322729669024 all complications 10 4.13E-05 1.092233668 rs7093688 166.189701331657 region-3 mi 10 3.03E-06 0.551061384 rs10829973 168.906817722485 region-3 mi 10 3.18E-05 0.412881356 rs10872807 169.781521075206 region-3 albu 10 3.06E-05 1.515882504 rs11254057 18.6893904254296 peal mi 10 3.08E-04 0.691541041 rs11596873 21.9131278839596 all albu 10 7.46E-05 0.80479347 rs11596873 21.9131278839596 region-1 albu 10 2.77E-04 0.798647829 rs2296734 21.9152520333512 all albu 10 8.26E-05 0.804479195 rs2296734 21.9152520333512 region-1 albu 10 2.39E-04 0.796984731 rs682970 29.6392920793462 peal albu 10 2.26E-04 2.288175676 rs6560771 3.4904017627776 region-3 albu 10 6.42E-05 0.543204468 rs12779658 34.0849548384841 region-1 stroke 10 5.03E-05 1.711792168 rs12779658 34.0849548384841 all stroke 10 4.48E-04 1.449574314 rs7910407 34.6693404983827 all albu 10 2.75E-05 0.947891134 rs2698119 35.4249468120362 peal albu 10 3.95E-04 1.312587232 rs11258843 35.67734675639 all mi 10 5.44E-05 0.60593456 rs11258843 35.67734675639 region-1 mi 10 1.20E-04 0.52836929 rs11258843 35.67734675639 peal mi 10 1.48E-04 0.60593456 rs11259112 37.476710507796 region-3 complications 10 9.08E-05 0.37037037 rs11259112 37.476710507796 region-3 albu 10 1.02E-04 0.350689397 rs12245743 37.5498221853839 region-3 albu 10 3.64E-05 0.290809328 rs12245743 37.5498221853839 region-3 complications 10 8.76E-05 0.346979866 rs10903809 4.20493460138504 region-3 complications 10 7.60E-05 0.692929293 rs9333202 40.2224358677407 all complications 10 3.18E-05 0.748544473 rs9333202 40.2224358677407 peal complications 10 4.70E-05 0.748544473 rs1868996 40.2617163344205 all complications 10 3.32E-05 0.749141034 rs1868996 40.2617163344205 peal complications 10 4.79E-05 0.749141034 rs7903259 43.1118170581317 region-3 mi 10 9.50E-05 0.579854651 rs10904908 43.1125576197743 region-3 mi 10 7.67E-05 0.575306914 rs11254592 43.3546138497456 all complications 10 7.07E-05 0.747811305 rs11254592 43.3546138497456 peal complications 10 2.04E-04 0.747811305 rs10828424 44.6204771222666 peal complications 10 4.11 E-04 1.288604079 rs11010400 46.4026689285391 peal albu 10 4.67E-04 2.047748535 rs1930227 46.860837705952 region-1 mi 10 6.13E-05 0.892203479 rs1930227 46.860837705952 all mi 10 1.83E-04 0.881249123 rs12764197 52.0355724861904 region-3 stroke 10 3.60E-05 2.135062612 rs1061577 53.5494142760699 all stroke 10 8.61 E-05 1.569939012 rs1061577 53.5494142760699 peal stroke 10 1.03E-04 1.569939012 rs1061577 53.5494142760699 region-1 stroke 10 3.29E-04 1.682015349 rs11008612 60.4222643542875 peal stroke 10 2.99E-04 1.701403629 rs16937197 64.0050134595734 all complications 10 1.90E-05 0.649640281 rs16937197 64.0050134595734 peal complications 10 3.07E-05 0.649640281 rs16937197 64.0050134595734 region-1 complications 10 7.13E-05 0.620560478 rs2488733 64.1308377956039 all mi 10 8.97E-05 0.573082915 rs2488733 64.1308377956039 peal mi 10 1.25E-04 0.573082915 rs3123669 66.7636922782213 region-3 stroke 10 4.34E-05 1.724014337 rs2484664 66.7695949110271 region-3 stroke 10 4.58E-05 1.726803173 rs7912740 67.2251098435599 peal stroke 10 4.89E-04 1.40722911 rs2002497 67.3692102005945 peal stroke 10 2.42E-04 1.44475427

Page 37 Table LxIs

rs7093687 67.4855589122908 all stroke 10 5.93E-05 1.561785764 rs7093687 67.4855589122908 peal stroke 10 7.39E-05 1.561785764 rs6413416 67.4869800654378 all stroke 10 5.43E-05 1.565492395 rs6413416 67.4869800654378 peal stroke 10 6.80E-05 1.565492395 rs6593482 67.4871807287061 all stroke 10 4.00E-05 1.583248212 rs6593482 67.4871807287061 peal stroke 10 5.17E-05 1.583248212 rs7913948 67.4873669984067 all stroke 10 6.28E-05 1.559508278 rs7913948 67.4873669984067 peal stroke 10 7.79E-05 1.559508278 rs3824613 67.4903689039669 all stroke 10 2.76E-05 1.593370771 rs3824613 67.4903689039669 peal stroke 10 3.78E-05 1.593370771 rs7919239 67.4998415649195 all stroke 10 5.75E-05 1.509058885 rs7919239 67.4998415649195 peal stroke 10 6.78E-05 1.509058885 rs7088096 68.2877607048191 peal stroke 10 4.47E-04 0.687411113 rs10795064 7.47816805404416 peal complications 10 4.65E-04 1.288699475 rs2171304 7.69100647300684 all complications 10 6.05E-06 0.779220779 rs2171304 7.69100647300684 all albu 10 1.89E-04 0.794032594 rs2171304 7.69100647300684 peal complications 10 2.88E-04 0.779220779 rs1203375 70.0953457368929 region-3 mi 10 9.58E-05 0.512522983 rs7916397 70.1269551230647 region-3 mi 10 2.76E-05 1.775899392 rs9299582 70.1274207170004 region-3 mi 10 5.48E-05 1.742174945 rs2224249 70.1348107182731 region-3 mi 10 9.49E-05 1.723404255 rs1932604 74.5233218030487 region-1 albu 10 1.29E-05 0.6 rs1932604 74.5233218030487 all albu 10 8.27E-05 0.704018545 rs1932604 74.5233218030487 region-1 complications 10 2.26E-04 0.682292756 rs1932604 74.5233218030487 peal albu 10 3.01 E-04 0.704018545 rs7912876 75.8986927810268 region-1 mi 10 5.14E-05 1.510265148 rs7905157 80.5886633179232 peal complications 10 3.35E-04 0.720154595 rs7908867 80.5889695945946 peal complications 10 4.53E-04 0.72649794 rs16917845 80.5900729018492 peal complications 10 4.39E-04 0.724856192 rs10998910 89.3508811577029 peal complications 10 4.79E-04 1.299011454 rs7071359 89.5696349655123 all complications 10 5.09E-05 1.324017976 rs7071359 89.5696349655123 peal complications 10 4.24E-04 1.324017976 rs7071359 89.5696349655123 region-1 complications 10 4.84E-04 1.30262212 rs748165 90.8738570820927 peal albu 10 2.38E-04 1.318447957 rs4393279 100.120978022217 region-3 albu 11 8.07E-05 1.686417455 rs1482047 102.319846345233 peal albu 11 3.40E-04 1.59675311 rs6589065 102.332618193842 peal albu 11 3.79E-04 1.830471738 rs1003081 114.376247596089 peal stroke 11 2.79E-04 1.392256581 rs2282648 118.221051047982 region-1 complications 11 5.29E-05 0.718493226 rs2282648 118.221051047982 region-1 albu 11 3.50E-04 0.734301676 rs726601 118.225300218032 region-1 complications 11 4.43E-05 0.721037998 rs726601 118.225300218032 region-1 albu 11 2.54E-04 0.735197056 rs1984602 119.893540138875 peal complications 11 3.92E-04 0.523752189 rs7947110 12.668172241806 peal albu 11 4.26E-04 1.295431033 rs2714050 122.492566974832 peal mi 11 2.46E-04 1.353817318 rs1647965 137.252642702028 all albu 11 6.45E-05 0.747487013 rs1647965 137.252642702028 region-1 albu 11 8.51 E-05 0.704809606 rs1647965 137.252642702028 peal albu 11 9.26E-05 0.747487013 rs1647966 137.253689976343 region-1 albu 11 7.77E-05 0.703409786 rs1647966 137.253689976343 all albu 11 9.32E-05 0.752289377 rs1647966 137.253689976343 peal albu 11 1.31 E-04 0.752289377

Paαe 38 Table 1.xls

rs10894319 137.264683398249 regιon-1 albu 11 5.11E-05 0.697216389 rs10894319 137.264683398249 all albu 11 6.57E-05 0.748170939 rs10894319 137.264683398249 peal albu 11 9.37E-05 0.748170939 rs1114418 137.273191762459 region-1 albu 11 8.80E-05 0.705079448 rs1114418 137.273191762459 all albu 11 1.30E-04 0.756665409 rs1114418 137.273191762459 peal albu 11 1.88E-04 0.756665409 rs10736593 137.288707594919 region-1 albu 11 8.97E-05 0.706085942 rs10736593 137.288707594919 all albu 11 1.48E-04 0.759486709 rs10736593 137.288707594919 peal albu 11 2.01 E-04 0.759486709 rs7111704 140.811595881386 peal albu 11 4.37E-04 0.551425853 rs4641492 142.776650083098 peal stroke 11 2.94E-04 0.701088864 rs901036 147.383450597822 region-1 stroke 11 6.26E-06 1.540115798 rs3741098 147.866426736432 all albu 11 9.27E-05 0.814111356 rs10743138 15.8236593042842 peal albu 11 2.22E-04 0.558197464 rs10743140 15.8261677781342 peal albu 11 1.92E-04 0.552637451 rs7119964 15.8262615434348 region-3 albu 11 6.70E-05 0.290896646 rs7119964 15.8262615434348 all albu 11 1.48E-04 0.549674298 rs7119964 15.8262615434348 peal albu 11 2.23E-04 0.549674298 rs11022119 18.5613033276383 region-3 complications 11 1.57E-05 2.037974684 rs10766122 20.5917927709138 all mi 11 3.89E-05 0.82929071 rs903808 20.9533593867268 region-3 mi 11 1.46E-05 1.805438851 rs903808 20.9533593867268 all mi 11 1 52E-04 1.297789772 rs11023705 21.0640298591974 peal albu 11 4.40E-04 0.788480644 rs3781749 27.2841869296751 region-1 complications 11 7.93E-05 0.744804897 rs3781749 27.2841869296751 all complications 11 3.68E-04 0.775010127 rs4922950 28.2337666227424 region-3 albu 11 6.45E-05 1.63848655 rs7117485 28.2624666501502 region-3 albu 11 4.60E-05 1.645914571 rs7121300 28.2630116733104 region-3 albu 11 3.59E-05 1.65963964 rs6483813 28.2632434536223 region-3 albu 11 3.59E-05 1.65963964 rs1487837 28.2905527991588 region-3 albu 11 4.60E-05 1.645914571 rs1386736 28.292921031467 region-3 albu 11 4.86E-05 1.650385488 rs11027609 30.1661898779073 all stroke 11 5.71 E-05 1.43104523 rs11027609 30.1661898779073 peal stroke 11 1.68E-04 1.43104523 rs11027609 30.1661898779073 region-1 stroke 11 3.32E-04 1.398513782 rs12294573 30.3329659951392 region-1 stroke 11 2.92E-05 0.557645194 rs12271990 32.188708758748 all mi 11 1 -75E-07 0.209127538 rs12271990 32.188708758748 peal mi 11 2.87E-06 0.209127538 rs12271990 32.188708758748 region-3 mi 11 1.72E-05 0.085239362 rs7126809 32.2281550524161 all stroke 11 2.43E-06 1.361677291 rs7126809 32.2281550524161 region-1 stroke 11 7.85E-06 1.697689661 rs1550617 33.326339526741 all stroke 11 2.54E-06 1.524401754 rs1550617 33.326339526741 peal stroke 11 3.12E-06 1.524401754 rs1550617 33.326339526741 region-1 mi 11 5.54E-05 0.763423564 rs1550617 33.326339526741 region-1 stroke 11 2.29E-04 1.536490365 rs1550617 33.326339526741 all mi 11 4.32E-04 0.8369379 rs224630 37.0581749906057 region-1 stroke 11 7.47E-06 1.417757169 rs4756093 40.9907393548657 peal complications 11 4.77E-04 1.283150188 rs1033282 47.5914524051819 all mi 11 4.63E-05 0.712327977 rs1033282 47.5914524051819 peal mi 11 4.98E-05 0.712327977 rs1033282 47.5914524051819 region-1 mi 11 3.33E-04 0.694136028 rs11033790 47.5966020402055 peal mi 11 4.30E-04 1.29944244

Paαe 39 Table 1.xls

rs4756347 47.6013682123729 peal mi 11 2.02E-04 0.739624167 rs1518758 47.6133344656023 all mi 11 4.18E-05 1.353143455 rs1518758 47.6133344656023 peal mi 11 4.45E-05 1.353143455 rs1518758 47.6133344656023 region-1 mi 11 4.87E-04 1.369008756 rs7940927 47.6163235491971 all mi 11 2.92E-05 0.671362997 rs7940927 47.6163235491971 peal mi 11 3.25E-05 0.671362997 rs7940927 47.6163235491971 all complications 11 3.59E-04 0.751166402 rs7940927 47.6163235491971 peal complications 11 3.73E-04 0.751166402 rs7117392 47.6251408609241 peal mi 11 1.13E-04 0.720573064 rs1568272 47.630856448272 peal mi 11 2.32E-04 0.730632535 rs4755461 47.6365347373469 all mi 11 2.92E-05 1.360528826 rs4755461 47.6365347373469 peal mi 11 3.14E-05 1.360528826 rs4755461 47.6365347373469 region-1 mi 11 4.34E-04 1.371741421 rs10836616 47.651556989763 all mi 11 1.66E-05 0.722233477 rs10836616 47.651556989763 peal mi 11 1.80E-05 0.722233477 rs10836616 47.651556989763 region-1 mi 11 2.32E-04 0.7091158 rs10836620 47.6668925476719 all mi 11 1.60E-05 0.719152795 rs10836620 47.6668925476719 peal mi 11 1.72E-05 0.719152795 rs10836620 47.6668925476719 region-1 mi 11 1.47E-04 0.698424478 rs1878840 47.6843190467627 region-1 complications 11 9.76E-05 1.307950658 rs7127861 47.8854723626458 all complications 11 6.79E-05 1.227738839 rs6485030 48.9984399979051 all mi 11 1.81 E-05 0.215038683 rs6485030 48.9984399979051 peal mi 11 1.21 E-04 0.215038683 rs1602007 53.6737357927586 region-1 complications 11 7.66E-05 0.660249271 rs11037970 55.1467483073904 region-3 albu 11 7.33E-05 4.290685225 rs7951911 56.278425521476 regioπ-1 stroke 11 4.47E-05 1.209667717 rs7952511 56.2791582895311 region-1 stroke 11 4.79E-05 1.225949821 rs966905 56.3118234610549 region-1 stroke 11 9.37E-06 1.264159142 rs11246628 58.7168861157355 all mi 11 1.25E-06 0.276902202 rs11246628 58.7168861157355 peal mi 11 8.75E-06 0.276902202 rs11246628 58.7168861157355 all stroke 11 6.17E-05 0.216899328 rs11246628 58.7168861157355 all albu 11 2.90E-04 1.821700467 rs11246628 58.7168861157355 peal stroke 11 3.46E-04 0.216899328 rs2844032 60.0536281679276 region-3 complications 11 1.03E-05 0.385431074 rs574695 60.0706165239241 peal complications 11 1.36E-04 0.773252406 rs574695 60.0706165239241 peal albu 11 3.57E-04 0.786775628 rs1303621 60.0721191189688 all complications 11 9.84E-05 0.769842007 rs1303621 60.0721191189688 peal complications 11 1.03E-04 0.769842007 rs667897 60.0797232352029 all complications 11 1.01 E-05 1.348876641 rs667897 60.0797232352029 peal complications 11 1.09E-05 1.348876641 rs11230180 60.083747726652 peal complications 11 4.05E-04 0.784766015 rs11230188 60.0854186451852 peal complications 11 3.81 E-04 1.459747878 rs11230197 60.0881597726699 all complications 11 4.94E-05 1.51311047 rs11230197 60.0881597726699 peal complications 11 1.24E-04 1.51311047 rs4980715 69.7864854871175 region-3 mi 11 7.92E-05 0.551859321 rs10501407 72.8653173637762 all albu 11 7.23E-05 0.644634921 rs10501407 72.8653173637762 peal albu 11 8.12E-05 0.644634921 rs10897992 72.8657537162395 all albu 11 6.05E-05 0.641908276 rs10897992 72.8657537162395 peal albu 11 6.83E-05 0.641908276 rs11233277 72.8725278295855 all albu 11 5.76E-05 0.66397387 rs11233277 72.8725278295855 peal albu 11 6.42E-05 0.66397387

Page 40 Table 1.xls

rs11237675 82.1029607054341 peal stroke 11 2.95E-04 1.390581767 rs10501441 82.99606230566 region-3 complications 11 8.46E-05 0.467994913 rs10751020 84.3112210630935 peal albu 11 1.93E-04 0.770610759 rs1878266 86.0727855852654 region-3 mi 11 4.81 E-05 1.607587223 rs11235074 89.2928218520372 peal complications 11 3.77E-04 1.277105647 rs4943980 89.2932482332503 peal complications 11 3.04E-04 1.281589258 rs7945575 89.3005452889486 peal complications 11 3.92E-04 1.278374737 rs6592344 89.3007625274781 peal complications 11 3.81E-04 1.275010563 rs7117839 89.3025652024805 peal complications 11 2.22E-04 1.288831646 rs10898674 89.3783976409605 all complications 11 6.16E-05 1.323964497 rs10898674 89.3783976409605 peal complications 11 6.42E-05 1.323964497 rs10898675 89.3798886258988 all complications 11 4.79E-05 1.332708177 rs10898675 89.3798886258988 peal complications 11 5.11 E-05 1.332708177 rs2186664 89.9483798897789 region-1 mi 11 6.14E-05 1.37069255 rs11018633 90.6355254912875 all mi 11 2.16E-06 0.235734168 rs11018633 90.6355254912875 peal mi 11 1.90E-05 0.235734168 rs11018633 90.6355254912875 all stroke 11 3.36E-05 0.128121682 rs11019014 90.8425478602868 peal stroke 11 2.34E-04 2.037216288 rs11019030 90.8486559648053 peal stroke 11 3.58E-04 1.998487293 rs11019031 90.8486803640941 peal stroke 11 3.54E-04 1.99976469 rs10765796 93.2918234900581 peal albu 11 1.89E-04 0.77799141 rs11215072 96.873483668615 region-1 stroke 11 1.38E-05 1.603978471 rs7926001 96.878409657363 region-1 stroke 11 2.30E-05 1.595397839 rs2897642 97.8183046783799 all complications 11 8.02E-05 0.804274994 rs10894967 98.070179571972 region-3 complications 11 7.51 E-05 0.499457754 rs1939046 98.7057994310465 region-3 complications 11 7.89E-05 2.281081081 rs10492276 103.979797646095 peal stroke 12 4.29E-04 0.694514295 rs924507 104.764255547416 region-3 albu 12 6.08E-05 1.656543843 rs9919707 11.641264429717 all mi 12 5.42E-05 1.468157929 rs9919707 11.641264429717 peal mi 12 6.01 E-05 1.468157929 rs6489600 11.6421613654635 all mi 12 7.85E-05 1.453938585 rs6489600 11.6421613654635 peal mi 12 8.54E-05 1.453938585 rs6489601 11.6429061707654 all mi 12 7.85E-05 1.453938585 rs6489601 11.6429061707654 peal mi 12 8.54E-05 1.453938585 rs6489602 11.6436002659191 all mi 12 3.32E-05 1.480362722 rs6489602 11.6436002659191 peal mi 12 3.70E-05 1.480362722 rs2191201 11.6529325178825 peal mi 12 4.85E-04 1.396054823 rs1036515 118.400290810883 all albu 12 4.89E-05 1.22101008 rs10466917 118.601601126595 region-3 complications 12 7.91E-06 1.796699388 rs10466917 118.601601126595 region-3 mi 12 4.80E-04 1.402549124 rs7300998 118.635452699068 all complications 12 4.86E-05 1.238510514 rs1011300 119.022020977257 all stroke 12 9.14E-05 0.668148035 rs1011300 119.022020977257 region-1 stroke 12 3.63E-04 0.609410481 rs1011300 119.022020977257 peal stroke 12 3.90E-04 0.668148035 rs7979656 119.030676687307 peal stroke 12 2.54E-04 1.406549675 rs4766526 119.037288699202 peal stroke 12 2.59E-04 1.403009497 rs28739424 121.161717777417 region-3 mi 12 2.77E-05 0.541152781 rs11066945 121.515267097719 all mi 12 1.01 E-06 0.164956367 rs11066945 121.515267097719 peal mi 12 1.71 E-05 0.164956367 rs11066945 121.515267097719 region-1 mi 12 7.98E-05 0.055856369 rs4766720 121.544988638806 all mi 12 4.17E-05 0.735731706

Paαe 41 Table LxIs

rs4766720 121.544988638806 peal mi 12 4.38E-05 0.735731706 rs4766720 121.544988638806 region-1 mi 12 4.41 E-04 1.383969231 rs1920584 121.547632748312 all mi 12 4.17E-05 0.735751726 rs1920584 121.547632748312 peal mi 12 4.39E-05 0.735751726 rs1920584 121.547632748312 region-1 mi 12 4.11 E-04 1.386694387 rs12309276 125.239146667541 all albu 12 7.47E-05 1.108515485 rs3759320 13.4356300849956 all mi 12 4.50E-05 1.121397993 rs1726392 133.382594359721 region-1 albu 12 2.05E-05 1.419180595 rs1726392 133.382594359721 all albu 12 1.93E-04 1.264434515 rs937527 134.46483636718 all albu 12 1.05E-05 1.441347476 rs937527 134.46483636718 peal albu 12 1.25E-05 1.441347476 rs1402337 134.492189670719 all albu 12 6.71 E-05 1.39126584 rs1402337 134.492189670719 peal albu 12 7.69E-05 1.39126584 rs1356952 134.516379599076 all albu 12 6.85E-05 1.390274628 rs1356952 134.516379599076 peal albu 12 7.49E-05 1.390274628 rs11065172 137.452285751161 peal mi 12 2.34E-04 0.72462896 rs11057690 140.116833697066 all stroke 12 6.28E-05 1.24458952 rs7135085 153.272961455109 peal mi 12 1.94E-04 0.661316996 rs897983 153.286978030728 peal mi 12 1.57E-04 0.676179597 rs11060924 163.690701260238 all mi 12 3.39E-05 1.871152545 rs11060924 163.690701260238 peal mi 12 8.71 E-05 1.871152545 rs7969971 164.168303881739 region-1 mi 12 7.29E-05 0.822313166 rs7969971 164.168303881739 all mi 12 3.18E-04 0.739977195 rs9634125 17.0362290065647 peal complications 12 4.59E-04 0.565933333 rs4495966 20.2332910258686 region-1 stroke 12 1.06E-05 0.597386546 rs888152 24.9156519774179 region-1 mi 12 5.34E-05 1.264792488 rs2110598 28.2851083125011 region-1 stroke 12 3.36E-05 1.627835851 rs16908422 28.4473601244537 region-3 complications 12 1.35E-05 0.254593176 rs6488711 31.3160606828002 all albu 12 7.95E-05 0.683005703 rs6488711 31.3160606828002 peal albu 12 1.63E-04 0.683005703 rs9332950 35.187678840779 region-3 complications 12 5.38E-05 0.411436541 rs1728200 35.6946076490617 all stroke 12 3.05E-05 1.608845703 rs1728200 35.6946076490617 region-1 stroke 12 7.51 E-05 1.803537348 rs751082 36.058784321799 peal stroke 12 4.13E-04 1.450211018 rs10161196 36.6299460935337 peal mi 12 3.14E-04 1.477136345 rs11044739 36.6391097021124 peal mi 12 3.15E-04 1.469191941 rs11044750 36.661680914377 peal mi 12 4.74E-04 1.481440665 rs7484891 37.351198630257 peal stroke 12 4.90E-04 0.723247693 rs11045190 38.1459417683985 region-3 stroke 12 1.07E-05 1.915637992 rs7304649 38.3452833944951 all mi 12 1.42E-06 0.335292345 rs7304649 38.3452833944951 peal mi 12 4.14E-06 0.335292345 rs7304649 38.3452833944951 region-1 mi 12 2.46E-04 0.327222532 rs10841978 41.1383076060196 all stroke 12 8.58E-06 0.661706534 rs10841978 41.1383076060196 peal stroke 12 2.34E-05 0.661706534 rs10841978 41.1383076060196 region-1 stroke 12 3.50E-05 0.593724058 rs722248 41.1452929830263 peal stroke 12 4.16E-04 0.662194738 rs7310117 41.175835195823 region-1 stroke 12 7.80E-06 0.531713106 rs7310117 41.175835195823 all stroke 12 4.77E-04 0.716480275 rs11046650 42.1378153541614 all stroke 12 3.85E-05 1.000403594 rs1406772 42.5654455241647 region-3 complications 12 5.87E-05 0.670903723 rs11047238 43.4532798150325 all mi 12 9.86E-05 1.048823017

Paαe 42 Table 1.xls

rs4963959 45.9032263303327 peal mi 12 2.05E-04 0.720878861 rs3852539 49.0934979457785 region-1 albu 12 3.21 E-05 1.330963455 rs3852539 49.0934979457785 region-1 complications 12 6.43E-05 1.228944886 rs3852539 49.0934979457785 all complications 12 1.58E-04 1.235513007 rs3852539 49.0934979457785 all albu 12 1.68E-04 1.34010374 rs3852539 49.0934979457785 peal albu 12 2.18E-04 1.34010374 rs2638952 49.4910218376811 all albu 12 8.53E-05 1.336600562 rs4931081 49.5536686928158 all albu 12 1.19E-05 1.377535714 rs4931081 49.5536686928158 peal albu 12 4.00E-04 1.377535714 rs4931081 49.5536686928158 regioπ-1 albu 12 4.80E-04 1.313553838 rs1872829 53.1502715153965 region-1 albu 12 3.05E-05 1.383647348 rs1872829 53.1502715153965 all albu 12 1.89E-04 1.27048823 rs12425397 53.1593592333186 regioπ-3 stroke 12 5.02E-06 7.203703704 rs4931059 53.5278895973791 all mi 12 2.06E-05 0.234939629 rs4931059 53.5278895973791 peal mi 12 1.28E-04 0.234939629 rs4931059 53.5278895973791 region-1 mi 12 1.28E-04 0.142343218 rs4931059 53.5278895973791 all stroke 12 1.35E-04 0.106625188 rs4931059 53.5278895973791 all albu 12 3.10E-04 2.067824925 rs2406853 56.0251406696145 region-1 stroke 12 3.62E-05 0.824100702 rs10736004 56.0262573304747 region-1 stroke 12 1.89E-05 0.823826736 rs17094227 57.087145105058 all mi 12 6.08E-05 0.298734126 rs17094227 57.087145105058 peal mi 12 1.80E-04 0.298734126 rs7303573 58.515078721315 all albu 12 2.40E-05 1.306394492 rs7303573 58.515078721315 peal albu 12 2.04E-04 1.306394492 rs11182904 58.6323471898771 regioπ-1 stroke 12 8.99E-05 2.167231638 rs7967892 58.8316738934898 peal albu 12 1.81 E-04 1.295607694 rs7307697 59.0114716574862 peal albu 12 4.23E-04 1.276940419 rs10748424 59.0603764005565 region-3 complications 12 9.99E-05 1.926762283 rs10748424 59.0603764005565 all complications 12 2.65E-04 1.24659428 rs11183154 59.3291099691675 region-3 complications 12 2.48E-05 0.426599874 rs11183154 59.3291099691675 all complications 12 3.07E-04 0.715609923 rs11183154 59.3291099691675 peal complications 12 4.01 E-04 0.715609923 rs2408467 60.0624292693207 peal mi 12 2.54E-04 0.359064762 rs2193662 60.7922864656269 region-1 complications 12 6.15E-05 0.595710332 rs2193662 60.7922864656269 region-1 albu 12 4.93E-04 0.605227301 rs12306495 60.8458830045707 region-1 complications 12 8.88E-05 0.272294669 rs1476581 62.6190168648924 peal stroke 12 3.24E-04 1.41883371 rs303765 65.7402370163665 peal complications 12 1.81 E-04 0.77347411 rs7314308 72.3880044462056 region-1 mi 12 3.38E-06 1.61977507 rs905559 73.1083116622183 peal stroke 12 2.43E-04 0.700687993 rs2723749 73.1151846414266 all stroke 12 6.26E-05 0.609897651 rs2723749 73.1151846414266 peal stroke 12 3.51 E-04 0.609897651 rs7960614 73.2363913718925 peal stroke 12 3.12E-04 0.693121895 rs11173654 73.2620671700936 peal stroke 12 2.67E-04 0.691219085 rs1993981 73.2720472637878 peal stroke 12 3.57E-04 0.695189284 rs10878017 74.5827365491651 all complications 12 6.75E-05 0.64710221 rs10878017 74.5827365491651 peal complications 12 8.26E-05 0.64710221 rs7975586 74.5901610726935 all complications 12 9.04E-05 0.699063167 rs7975586 74.5901610726935 peal complications 12 1.OOE-04 0.699063167 rs17099254 74.6121015348288 peal complications 12 3.43E-04 0.731145355 rs17801910 77.9980913608583 peal albu 12 3.58E-04 1.833003511

Page 43 Table 1.xls

rs12230755 78.3444547653161 region-3 complications 12 2.77E-05 0.455732946 rs17802054 80.0795134234715 peal complications 12 4.86E-04 1.275870031 rs973328 80.0862424462226 peal complications 12 4.75E-04 1.277600849 rs2169288 82.9928374521907 peal complications 12 3.57E-04 0.654310345 rs10785115 82.9956238825745 peal complications 12 2.08E-04 0.637005067 rs17770992 83.0017178723661 all complications 12 6.25E-05 1.126328217 rs17770992 83.0017178723661 all albu 12 9.13E-05 1.101011312 rs17770992 83.0017178723661 region-1 albu 12 3.16E-04 1.153945971 rs10879957 83.4780556695375 peal complications 12 3.80E-04 0.783882784 rs6539663 85.1295912722118 region-1 stroke 12 8.79E-06 1.809304367 rs12579380 90.1031203075267 region-1 stroke 12 9.21 E-05 1.189828431 rs1404868 93.6517296770377 all complications 12 7.35E-05 0.761314831 rs1404868 93.6517296770377 all stroke 12 2.58E-04 0.673707649 rs1404868 93.6517296770377 peal complications 12 2.87E-04 0.761314831 rs1404868 93.6517296770377 peal stroke 12 2.89E-04 0.673707649 rs7302315 93.6650009427214 all complications 12 3.07E-05 0.763754234 rs7302315 93.6650009427214 peal complications 12 2.62E-04 0.763754234 rs7302315 93.6650009427214 region-1 albu 12 3.08E-04 0.808316409 rs7302315 93.6650009427214 all stroke 12 4.98E-04 0.691738029 rs12814669 93.670394547187 all complications 12 3.07E-05 0.765409191 rs12814669 93.670394547187 peal complications 12 2.91 E-04 0.765409191 rs12814669 93.670394547187 region-1 albu 12 2.96E-04 0.810260831 rs12814669 93.670394547187 all stroke 12 3.95E-04 0.686648647 rs12814669 93.670394547187 peal stroke 12 4.04E-04 0.686648647 rs1389798 93.6878459801516 all complications 12 2.74E-05 0.764457478 rs1389798 93.6878459801516 peal complications 12 2.69E-04 0.764457478 rs1389798 93.6878459801516 all stroke 12 3.76E-04 0.686300594 rs1389798 93.6878459801516 peal stroke 12 3.82E-04 0.686300594 rs1389798 93.6878459801516 region-1 albu 12 3.95E-04 0.813924863 rs1507216 93.6978229336937 all complications 12 2.60E-05 0.766661438 rs1507216 93.6978229336937 peal complications 12 3.41 E-04 0.766661438 rs1507216 93.6978229336937 region-1 albu 12 3.71 E-04 0.813740601 rs1507214 93.7054893230049 all complications 12 9.34E-05 0.773226995 rs7966105 93.7074981832055 all complications 12 7.23E-05 0.777017179 rs7966105 93.7074981832055 region-1 albu 12 3.75E-04 0.803007323 rs1545741 93.8102694443101 all mi 12 1.47E-07 0.061751733 rs1545741 93.8102694443101 region-1 mi 12 2.91 E-05 0.090968252 rs1545741 93.8102694443101 all stroke 12 3.50E-05 0 rs1545741 93.8102694443101 peal mi 12 1.21 E-04 0.061751733 rs7977693 96.0113964909251 peal albu 12 3.93E-04 1.386889446 rs10859340 96.0362730555371 region-1 albu 12 4.89E-05 0.716530737 rs10859340 96.0362730555371 all albu 12 3.24E-04 0.788712452 rs17662568 96.0519838499415 region-3 stroke 12 5.32E-05 1.871745276 rs10777487 96.4819852708201 all complications 12 8.63E-05 1.188141112 rs10777487 96.4819852708201 region-1 complications 12 2.79E-04 1.179080839 rs4620786 98.5146663573992 all stroke 12 6.05E-05 1.398391011 rs4620786 98.5146663573992 peal stroke 12 4.52E-04 1.398391011 rs7988493 104.345199919444 region-3 albu 13 1.37E-06 0.46888361 rs17081709 11.5178067483563 all mi 13 3.94E-05 1.651657286 rs17081709 11.5178067483563 peal mi 13 7.53E-05 1.651657286 rs17081709 11.5178067483563 region-1 mi 13 1.70E-04 1.763059701

Page 44 Table LxIs

rs1295890 110.25925681808 regioπ-1 albu 13 7.00E-05 1.198762484 rs1295890 110.25925681808 all albu 13 3.60E-04 1.164323587 rs4769010 18.0926137707217 all complications 13 4.89E-05 0.845446897 rs9506133 18.1151416375156 all complications 13 1.41E-05 0.787882233 rs2031280 18.9316637311741 peal complications 13 1.76E-04 1.786688282 rs17073897 18.9768544566485 peal complications 13 2.80E-04 1.752670863 rs719199 18.993752986456 peal complications 13 3.98E-04 1.723784707 rs12875231 19.0291927395484 peal complications 13 3.44E-04 1.759494664 rs1747062 19.0307425165325 peal complications 13 4.81 E-04 1.706371191 rs634413 19.2161039082822 region-1 albu 13 7.43E-05 1.295214958 rs634413 19.2161039082822 all complications 13 4.95E-04 1.234722851 rs2555607 25.5575369743991 all complications 13 8.49E-05 1.253240841 rs2858124 25.5597720127349 all complications 13 8.15E-05 1.250319534 rs1337966 26.412220005048 all mi 13 1.58E-05 0.468394437 rs1337966 26.412220005048 peal mi 13 4.27E-05 0.468394437 rs9530648 27.3240210816733 region-3 stroke 13 8.70E-05 1.723669725 rs9547919 30.8760005037808 region-3 stroke 13 4.33E-05 1.963906582 rs9548386 33.0337596810029 all mi 13 2.74E-05 0.385352667 rs9548386 33.0337596810029 peal mi 13 8.30E-05 0.385352667 rs9525514 38.3074674718551 region-3 albu 13 9.42E-05 1.697344935 rs7334517 40.0490868202634 all complications 13 3.60E-05 0.662411406 rs7334517 40.0490868202634 peal complications 13 4.08E-05 0.662411406 rs17641512 40.0566376455566 all complications 13 3.60E-05 0.662411406 rs17641512 40.0566376455566 peal complications 13 4.09E-05 0.662411406 rs9595168 41.8879155577805 region-1 stroke 13 2.00E-05 1.398591406 rs7317235 43.1013612089089 all complications 13 1.54E-05 0.747270433 rs7317235 43.1013612089089 peal complications 13 1.95E-05 0.747270433 rs4942969 45.2727837370374 peal complications 13 3.63E-04 1.32625858 rs9563077 45.324785485333 region-1 mi 13 1.92E-05 1.67745098 rs9597493 46.6645890374332 peal stroke 13 1.89E-04 1.405223575 rs12431160 46.8884720588235 all complications 13 3.56E-05 0.870171737 rs12431160 46.8884720588235 region-1 complications 13 4.17E-04 0.888693057 rs2031817 47.1390694385027 peal stroke 13 3.75E-04 1.435903093 rs17266631 47.1574972192513 peal stroke 13 2.20E-04 1.452405052 rs17653276 47.2085614705882 peal stroke 13 1.74E-04 1.462726745 rs609856 47.2449347058824 peal stroke 13 1.35E-04 1.46747566 rs17056214 47.8927712299465 all mi 13 2.66E-06 0.172900101 rs17056214 47.8927712299465 peal mi 13 3.50E-05 0.172900101 rs17056214 47.8927712299465 region-1 mi 13 9.76E-05 0.13877111 rs12427691 49.923055771182 all mi 13 2.07E-07 0.440537127 rs12427691 49.923055771182 peal mi 13 9.08E-07 0.440537127 rs12427691 49.923055771182 region-3 mi 13 1.78E-04 0.342096774 rs12427691 49.923055771182 region-1 mi 13 4.47E-04 0.49810685 rs11839567 50.3740085370287 all mi 13 1.26E-06 1.288843491 rs11839567 50.3740085370287 region-1 mi 13 4.36E-04 1.293302284 rs4126982 50.3772469565042 all mi 13 2.55E-06 1.257277843 rs17080594 50.3945812580316 all mi 13 8.67E-06 1.268841308 rs17080594 50.3945812580316 region-1 mi 13 3.34E-04 1.386312748 rs9592445 50.4061275656007 peal complications 13 2.82E-04 0.75026839 rs9317560 50.4106565909645 peal complications 13 4.64E-04 0.770402261 rs2324872 50.4119178426627 peal complications 13 1.96E-04 0.752561072

Page 45 Table 1.xls

rs7139910 50.4245874372369 all mi 13 3.09E-05 1.256614624 rs2875681 56.6165053090355 all stroke 13 9.46E-05 0.945922984 rs7330231 57.047850504054 region-1 stroke 13 4.22E-06 1.512195122 rs7330231 57.047850504054 all stroke 13 6.25E-05 1.398367812 rs9285295 58.535039362341 region-3 stroke 13 1.51 E-05 1.491710875

γS12585923 59.0727863199175 peal stroke 13 4.94E-04 1.833970276 rs1929751 59.2271873775168 region-1 albu 13 9.18E-05 0.553385128 rs1929751 59.2271873775168 all albu 13 1.38E-04 0.637594808 rs1929751 59.2271873775168 peal albu 13 1.70E-04 0.637594808 rs1929751 59.2271873775168 region-1 complications 13 3.43E-04 0.637441307 rs985288 6.67821401547051 region-1 mi 13 1.97E-05 1.050923035 rs985288 6.67821401547051 all mi 13 1.96E-04 1.063825851 rs9506890 6.7954691279902 region-3 complications 13 4.14E-05 0.795069337 rs2585512 60.8483360582192 all mi 13 7.82E-05 0.449963057 rs2585512 60.8483360582192 peal mi 13 1.16E-04 0.449963057 rs9574187 60.8485405792498 all stroke 13 7.42E-05 1.043967087 rs9574187 60.8485405792498 region-3 stroke 13 2.52E-04 1.007911392 rs12860641 61.0028956401514 all stroke 13 8.37E-05 1.295136395 rs12860641 61.0028956401514 region-1 stroke 13 4.76E-04 1.309774436 rs12100200 64.8497779751297 all stroke 13 1.86E-07 1.312832643 rs12100200 64.8497779751297 region-1 stroke 13 5.66E-05 1.224762873 rs9319065 64.8527645425184 all stroke 13 3.48E-06 1.278884598 rs9319065 64.8527645425184 region-1 stroke 13 5.66E-05 1.224762873

γS7987278 66.0077265143784 region-3 mi 13 7.84E-06 8.300970874 rs7983063 70.2123806389255 region-1 albu 13 8.98E-05 0.840893525 rs3897474 73.7391720649432 region-1 albu 13 7.47E-05 0.811494253 rs11070103 74.0994390380062 all complications 13 8.22E-05 1.145623963 rs11070103 74.0994390380062 region-3 complications 13 1.55E-04 1.600781053 rs10508010 74.1013900754186 all complications 13 7.56E-05 1.145471411 rs10508010 74.1013900754186 region-3 complications 13 1.86E-04 1.591751918 rs1630807 74.2266925155067 peal mi 13 2.40E-04 0.748368572 rs4771911 74.3957082935776 peal albu 13 3.23E-04 0.675069423 rs7983524 77.53874566161 region-1 mi 13 4.84E-05 1.250187777 rs7983524 77.53874566161 all mi 13 1.63E-04 1.12815534 rs2389316 78.2611130244903 peal complications 13 3.47E-04 1.351263099 rs9517529 79.1205129878007 region-3 stroke 13 9.79E-05 1.359157388 rs912369 82.6716966848818 peal stroke 13 2.24E-04 1.548725668 rs6491586 82.7874980639262 peal stroke 13 2.25E-04 1.558819492 rs9557510 82.7890106274123 peal stroke 13 3.91 E-04 1.53403334 rs7139858 83.5778249098521 region-1 complications 13 5.36E-05 0.791148673 rs7139858 83.5778249098521 region-1 mi 13 1.43E-04 0.817502259 rs1969793 85.8825661452444 peal stroke 13 4.38E-04 1.395203886 rs988026 86.6158823119664 peal mi 13 2.68E-04 1.610554601 rs9519469 88.7937571715262 region-3 stroke 13 3.81 E-05 1.793084216 rs1220573 9.68060974953247 region-3 stroke 13 1.59E-06 9.951162791 rs1220573 9.68060974953247 all stroke 13 1.71 E-06 3.646978022 rs1220573 9.68060974953247 peal stroke 13 1.11 E-05 3.646978022 rs11843348 90.8613555164458 all mi 13 5.61 E-07 0.036322572 rs11843348 90.8613555164458 region-3 mi 13 1.32E-04 0 rs17792222 101.591330203109 all stroke 14 4.15E-05 2.105937922 rs17792222 101.591330203109 peal stroke 14 5.82E-05 2.105937922

Page 46 Table LxIs

rs941845 104.012647826579 region-3 complications 14 6.28E-05 1.893927694 rs11846532 109.33344574519 peal complications 14 2.28E-04 0.776150646 rs6575613 117.350117434801 peal complications 14 4.50E-04 1.385319347 rs11850870 121.629353158503 region-1 mi 14 3.61 E-05 1.006071576 rs1746596 130.906756246244 region-3 complications 14 7.93E-05 0.731931812 rs1746595 130.907436012072 region-3 complications 14 8.22E-05 0.712522141 rs1678009 130.908147014404 region-3 complications 14 7.93E-05 0.735360811 rs10131139 132.278260407308 all stroke 14 6.18E-05 0.621804567 rs10131139 132.278260407308 peal stroke 14 7.40E-05 0.621804567 rs10131139 132.278260407308 region-3 stroke 14 2.42E-04 0.476923077 rs9888595 134.812477928721 region-3 stroke 14 5.78E-05 0.518286311 rs5742878 14.1632841187602 all mi 14 2.17E-05 0.457005508 rs5742878 14.1632841187602 peal mi 14 3.31 E-05 0.457005508 rs17435983 26.5959558000713 regioπ-3 mi 14 3.86E-05 0.370635748 rs1278886 31.6796796928042 region-1 mi 14 9.02E-05 1.391263871 rs11848645 37.866943264409 all albu 14 1.96E-05 1.326238339 rs11848645 37.866943264409 peal albu 14 2.10E-05 1.326238339 rs11848645 37.866943264409 region-1 albu 14 7.29E-05 1.380780102 rs17104962 43.1301420672896 all mi 14 2.37E-08 0.029620035 rs17104962 43.1301420672896 region-1 mi 14 7.86E-05 0 rs17104962 43.1301420672896 all stroke 14 8.96E-05 0.057009889 rs17104962 43.1301420672896 region-3 mi 14 2.35E-04 0.063862928 rs1956517 43.3338342751659 all mi 14 1.71 E-06 0.300728291 rs1956517 43.3338342751659 peal mi 14 9.35E-06 0.300728291 rs2154294 45.023986598324 peal stroke 14 1.43E-04 1.419070613 rs2455974 46.3370314289692 peal mi 14 4.63E-04 1.482982929 rs17743255 50.7469672461658 region-3 complications 14 7.77E-05 0.444444444 rs2352906 51.647591747577 peal complications 14 4.57E-04 0.70803485 rs12892499 51.6543898579439 peal complications 14 3.77E-04 0.698450569 rs10143885 67.9420995664852 peal stroke 14 3.53E-04 1.389991063 rs10136336 67.9448261299501 all stroke 14 8.32E-05 1.410075937 rs10136336 67.9448261299501 peal stroke 14 1.89E-04 1.410075937 rs407929 74.1720241854851 peal mi 14 1.63E-04 1.398322851 rs407929 74.1720241854851 peal complications 14 3.95E-04 1.35795436 rs194782 74.1781588805839 peal complications 14 1.28E-04 1.39578649 rs194782 74.1781588805839 peal mi 14 1.53E-04 1.400966184 rs194781 74.1783436087976 all mi 14 7.03E-05 1.41256288 rs194781 74.1783436087976 all complications 14 7.38E-05 1.40941434 rs194781 74.1783436087976 peal complications 14 7.96E-05 1.40941434 rs194781 74.1783436087976 peal mi 14 1.00E-04 1.41256288 rs168965 74.1818892449004 all complications 14 8.41 E-05 1.405908096 rs168965 74.1818892449004 all mi 14 8.41 E-05 1.404589372 rs168965 74.1818892449004 peal complications 14 9.04E-05 1.405908096 rs168965 74.1818892449004 peal mi 14 1.33E-04 1.404589372 rs1243446 8.73231619824919 all complications 14 6.09E-05 0.758467555 rs1243446 8.73231619824919 peal complications 14 6.48E-05 0.758467555 rs2282036 8.98971631672481 peal stroke 14 1.47E-04 0.666181261 rs2358785 84.053850397802 region-3 stroke 14 8.10E-05 1.682356406 rs2286412 84.1758301015762 region-3 stroke 14 2.46E-06 0.645002773 rs7145739 84.7022665282867 all stroke 14 6.39E-05 1.2983076 rs8017215 86.8858217682396 all complications 14 8.81 E-05 1.261419444

Page 47 Table 1.xls

rs11845632 89.2209825107338 region-1 albu 14 5.13E-05 1.119142723 rs11845632 89.2209825107338 all albu 14 1.69E-04 1.143543124 rs11850956 89.2267952695031 region-1 albu 14 4.27E-05 1.129245148 rs11850956 89.2267952695031 all albu 14 1.56E-04 1.168398382 rs11850956 89.2267952695031 all complications 14 3.16E-04 1.192918193 rs10873339 90.5145266157699 region-1 albu 14 9.08E-05 0.822504276 rs1241929 91.6329234503467 peal albu 14 4.69E-04 1.482319384 rs1241940 91.6372775075817 peal albu 14 2.58E-04 1.501952741 rs12895787 91.6426773251078 all albu 14 7.20E-05 1.543233115 rs12895787 91.6426773251078 peal albu 14 1.06E-04 1.543233115 rs12895787 91.6426773251078 all complications 14 2.44E-04 1.558428362 rs12895787 91.6426773251078 peal complications 14 2.69E-04 1.558428362 rs869346 91.6597467549083 all albu 14 6.89E-05 1.552570844

γS869346 91.6597467549083 peal albu 14 7.84E-05 1.552570844 rs869346 91.6597467549083 all complications 14 3.23E-04 1.539385207 rs869346 91.6597467549083 peal complications 14 3.52E-04 1.539385207 rs2401841 99.991491327009 peal albu 14 2.10E-04 1.321116139 rs17117193 10.1129523824034 region-3 complications 15 9.66E-05 0.593173547 rs12594942 100.765643823196 region-1 stroke 15 4.11E-05 0.594899425 rs12594942 100.765643823196 all stroke 15 2.14E-04 0.703661582 rs12594942 100.765643823196 peal stroke 15 3.07E-04 0.703661582 rs1026453 101.346803777862 region-3 complications 15 1.30E-05 0.501437908 rs16975959 104.108661182386 all mi 15 1.26E-07 0.163199491 rs16975959 104.108661182386 peal mi 15 4.46E-06 0.163199491 rs16975959 104.108661182386 region-1 mi 15 4.21 E-05 0.128859504 rs16975959 104.108661182386 all complications 15 3.10E-04 0.524506276 rs16975959 104.108661182386 all stroke 15 3.19E-04 0.221684027 rs16975959 104.108661182386 peal complications 15 4.88E-04 0.524506276 rs4275832 107.558258276308 region-1 mi 15 3.86E-06 0.699399164 rs4275832 107.558258276308 all mi 15 7.53E-05 0.766310048 rs7175099 107.577918901424 region-1 mi 15 3.65E-05 0.730111149 rs7175099 107.577918901424 all mi 15 1.87E-04 0.788718174 rs2654981 112.357639941574 peal albu 15 1.97E-04 1.291059089 rs7169478 37.1583911858104 peal mi 15 2.95E-04 1.479749934 rs7162070 37.1640414387207 peal mi 15 4.21 E-04 1.48571476 rs1876853 37.1643723991946 peal mi 15 4.21 E-04 1.48571476 rs8029602 37.1768306020947 peal mi 15 4.74E-04 1.480047647 rs4775656 44.359075655971 peal mi 15 4.02E-04 1.347060047 rs281302 44.9179844750701 peal complications 15 1.34E-04 1.298037645 rs1035704 44.9362096557038 peal complications 15 2.43E-04 1.311352595 rs4775698 44.9420183659674 peal complications 15 2.10E-04 1.311147407 rs765 44.9628865477231 all albu 15 5.79E-05 0.761834893 rs765 44.9628865477231 peal albu 15 7.39E-05 0.761834893 rs3809485 44.9649154987888 peal albu 15 1.54E-04 1.293884134

γS477571 1 44.9675754818105 peal albu 15 2.52E-04 0.778366081

γS4775711 44.9675754818105 peal complications 15 4.90E-04 0.78709177 rs16962997 45.236087233789 all mi 15 2.70E-05 1.389085887 rs1147138 45.3671009177623 all mi 15 9.50E-06 1.388475016 rs1147138 45.3671009177623 peal mi 15 6.97E-05 1.388475016 rs12595526 45.3731970338139 all mi 15 1.10E-05 1.389821771 rs12595526 45.3731970338139 peal mi 15 6.68E-05 1.389821771

Page 48 Table1.xls

rs1124769 45.3895650121405 peal mi 15 1.99E-04 1.382710561 rs17647040 45.3900380609687 all mi 15 8.40E-06 1.405465653 rs17647040 45.3900380609687 peal mi 15 4.87E-05 1.405465653 rs7177664 45.3938214223878 all mi 15 2.72E-05 1.328550747 rs2433285 45.6012890341133 regioπ-1 complications 15 4.00E-05 0.746344588 rs11633570 51.5399487379029 all mi 15 8.28E-05 0.692552001 rs11633570 51.5399487379029 peal mi 15 8.95E-05 0.692552001 rs10519003 51.5401253133169 all mi 15 4.31 E-05 0.691133198 rs10519003 51.5401253133169 peal mi 15 5.11E-05 0.691133198 rs10519003 51.5401253133169 region-1 mi 15 2.63E-04 0.658930955 rs17302379 51.5434948670758 peal mi 15 1.51 E-04 0.70885158 rs4592597 51.5693524807175 peal mi 15 4.29E-04 0.758511678 rs10519051 53.2969660830046 all mi 15 9.99E-05 1.362159494 rs10519051 53.2969660830046 region-3 complications 15 3.46E-04 2.750601619 rs11637964 60.0852487815133 region-1 stroke 15 7.95E-05 1.538987044 rs756625 60.42838784472 region-3 complications 15 1.90E-05 0.519979508 rs7176986 62.8328892105713 all stroke 15 3.12E-05 1.446821983 rs7176986 62.8328892105713 region-1 stroke 15 8.03E-05 1.674865859 rs7170930 62.8337938326539 all stroke 15 3.07E-05 1.478489122 rs7170930 62.8337938326539 region-1 stroke 15 7.88E-05 1.71035837 rs7171902 62.8352508345922 all stroke 15 3.07E-05 1.466469428 rs7171902 62.8352508345922 region-1 stroke 15 7.88E-05 1.699444885 rs8031930 70.8022235550395 region-3 stroke 15 1.76E-06 1.689278683 rs11072153 70.8023826477245 region-3 stroke 15 2.61 E-07 1.859594531 rs10851817 70.8026729353252 region-3 stroke 15 1.76E-06 1.719205298 rs7178130 71.5719036966434 peal mi 15 4.11 E-04 1.313526605 rs8034281 72.5672451636749 region-3 complications 15 4.14E-05 1.781263809 rs8034281 72.5672451636749 region-3 albu 15 3.02E-04 1.370131058 rs939971 75.2415071050504 region-3 mi 15 9.94E-05 1.330748241 rs11073505 80.076520100075 all stroke 15 6.37E-05 3.160883464 rs11073505 80.076520100075 peal stroke 15 1.51 E-04 3.160883464 rs2927035 80.2364436382682 region-3 albu 15 8.44E-05 1.706282513 rs2344863 80.3192505914398 all albu 15 3.09E-05 1.247111111 rs1444309 80.741134883776 region-1 stroke 15 5.11 E-05 1.401889062 rs16941252 83.2729009279176 peal stroke 15 4.79E-04 1.680193204 rs7342638 85.6156603915525 all complications 15 7.11 E-05 0.723512966 rs7342638 85.6156603915525 peal complications 15 4.64E-04 0.723512966 rs16944155 85.7002829658261 all complications 15 5.65E-05 0.755765056 rs16944155 85.7002829658261 all mi 15 2.79E-04 0.683115252 rs2562181 0.0142484732158437 all stroke 16 5.90E-05 2.155086219 rs2562181 0.0142484732158437 peal stroke 16 9.29E-05 2.155086219 rs382888 100.967339713155 region-3 albu 16 1.04E-05 1.66953331 rs11150193 104.518468013889 peal mi 16 4.36E-04 1.445106469 rs7191101 104.651064371893 peal mi 16 2.97E-04 1.372965752 rs10514479 104.730171358629 region-1 albu 16 8.90E-05 2.106976744 rs9938831 11.0219207980409 all stroke 16 8.46E-05 1.107034314 rs7191770 11.5916877481414 all mi 16 6.66E-08 0.059178744 rs7191770 11.5916877481414 region-1 mi 16 4.02E-05 0 rs7191770 11.5916877481414 peal mi 16 7.30E-05 0.059178744 rs1029969 12.0300990630897 region-1 stroke 16 7.80E-05 0.622401132 rs7195806 124.67689138522 peal complications 16 2.54E-04 0.766989253

Page 49 Table LxIs

rs10863213 125.705451219039 regιon-3 complications 16 5.54E-07 0.607130516 rs7184076 16.8910247459535 region-3 albu 16 6.55E-06 1.803891449 rs7184076 16.8910247459535 region-3 complications 16 2.74E-04 1.783291977 rs11645904 16.8917414998176 region-3 albu 16 7.58E-06 1.786882947 rs11645904 16.8917414998176 region-3 complications 16 3.76E-04 1.754059248 rs17567906 16.8920309965037 region-3 albu 16 4.17E-06 1.817654166 rs17567906 16.8920309965037 region-3 complications 16 2.93E-04 1.772385692 rs7185053 27.3102165633791 peal albu 16 1.96E-04 0.705783877 rs7184960 315.702338927991 all mi 16 2.04E-05 1.492077605 rs7184960 315.702338927991 peal mi 16 1.95E-04 1.492077605 rs11641790 315.819328641039 all mi 16 9.89E-05 1.449763688 rs11641790 315.819328641039 peal mi 16 3.79E-04 1.449763688 rs4781958 32.4735850886718 all stroke 16 9.75E-05 1.287580636 rs2270459 322.891672983216 peal mi 16 1.73E-04 1.496395302 rs208591 42.6218986788427 peal complications 16 2.73E-04 0.780549683 rs271012 45.3466734187937 peal mi 16 4.35E-04 1.345785637 rs16973718 45.4145040843635 all mi 16 1.73E-10 0.043593563 rs16973718 45.4145040843635 region-1 mi 16 2.00E-07 0.062781457 rs16973718 45.4145040843635 all stroke 16 1.02E-05 0.084053742 rs16973718 45.4145040843635 peal mi 16 1.92E-05 0.043593563 rs16973718 45.4145040843635 all albu 16 3.21 E-04 1.910491676 rs7203172 48.842530986344 all complications 16 1.88E-05 0.636107635 rs7203172 48.842530986344 peal complications 16 3.53E-05 0.636107635 rs7203172 48.842530986344 all albu 16 4.19E-05 0.630834268 rs7203172 48.842530986344 peal albu 16 7.61 E-05 0.630834268 rs7193007 49.1599090713726 all albu 16 5.34E-05 1.384734772 rs7193007 49.1599090713726 peal albu 16 6.37E-05 1.384734772 rs9940288 5.02479864852112 peal complications 16 2.80E-04 1.683068037 rs17775330 58.3666023909524 peal complications 16 3.14E-04 1.400080476 rs6500336 62.6500155682138 peal complications 16 3.76E-04 1.473955179 rs16948985 62.8072995356837 peal complications 16 1.94E-04 1.43944192 rs17823223 69.6794333148209 all complications 16 1.97E-05 0.68324724 rs17823223 69.6794333148209 peal complications 16 8.75E-05 0.68324724 rs17205999 71.541784811494 peal complications 16 4.80E-04 0.777827476 rs865094 73.529075232093 peal complications 16 3.40E-04 1.408938172 rs243849 73.5451575573278 peal complications 16 3.75E-04 1.426391269 rs243839 73.5593342524906 peal complications 16 1.86E-04 1.430326283 rs13339550 73.6544940143962 region-3 mi 16 9.50E-05 2.97596302 rs1362400 73.6647128624868 region-3 mi 16 6.55E-05 2.936006826 rs16955364 73.6691477382081 region-3 mi 16 9.08E-05 3.310053118 rs194168 73.7144207384286 region-3 mi 16 6.55E-05 2.936006826 rs12443955 73.9930260572249 peal mi 16 1.81 E-04 0.738552745 rs36017 73.9936063319718 peal mi 16 2.28E-04 1.316320762 rs3785157 74.0126913085741 peal mi 16 3.40E-04 0.747802564 rs43216 76.4151725304702 region-3 albu 16 1.60E-06 0.587755102 rs11641090 77.6384972897737 region-1 stroke 16 5.39E-05 0.522043644 rs10083735 77.6417600070791 region-1 stroke 16 7.86E-05 0.532522796 rs10083736 77.6418155755347 region-1 stroke 16 7.61 E-05 0.531914894 rs7191772 79.2653354814061 peal complications 16 3.12E-04 1.851357061 rs17256169 8.32946758872583 region-1 complications 16 6.57E-05 0.436520627 rs11649061 84.3940471227819 region-1 complications 16 3.06E-05 1.360128225

Page 50 Table 1.xls

rs1865977 84.7590916903702 all albu 16 2.81 E-05 0.796303219 rs1865977 84.7590916903702 region-1 albu 16 1.47E-04 0.734743108 rs2281850 85.7683226599805 peal stroke 16 3.78E-04 0.714186117 rs9937452 88.7410784444605 region-1 albu 16 1.94E-05 0.700120891 rs4888286 89.1766331716279 all complications 16 5.39E-06 0.76452632 rs4888286 89.1766331716279 all albu 16 1.38E-04 0.806449218 rs4888286 89.1766331716279 peal complications 16 1.63E-04 0.76452632 rs4888881 97.9199112473908 region-1 stroke 16 8.79E-05 1.513433633 rs4888881 97.9199112473908 all stroke 16 1.33E-04 1.390422141 rs8047671 97.979302357567 peal stroke 16 2.30E-04 1.397640054 rs1349 97.9886419313603 all stroke 16 9.11 E-05 1.391288897 rs1349 97.9886419313603 region-1 stroke 16 1.44E-04 1.4807892 rs1349 97.9886419313603 peal stroke 16 2.80E-04 1.391288897 rs4788933 103.488226869799 peal mi 17 1.77E-04 0.744039161 rs4238998 103.488351619311 all mi 17 3.21 E-05 0.731279427 rs4238998 103.488351619311 peal mi 17 8.26E-05 0.731279427 rs2590260 103.495425483693 peal mi 17 4.63E-04 0.765636918 rs12450896 103.522131330014 peal mi 17 3.88E-04 0.752604603 rs16955918 13.4608650147663 region-1 mi 17 1.20E-05 2.016089949 rs16955918 13.4608650147663 all mi 17 1.36E-04 1.6775932 rs16955918 13.4608650147663 peal mi 17 1.92E-04 1.6775932 rs9891554 17.8280958503799 peal stroke 17 2.77E-04 1.463869049 rs7213824 2.91679067692994 region-3 albu 17 4.95E-05 1.589908585 rs9902506 21.2569757604809 peal stroke 17 3.72E-04 2.257834758 rs6503352 23.1276950581953 peal albu 17 2.30E-04 2.001138434 rs9911421 23.1577538482892 peal albu 17 2.55E-04 2.018771754 rs2190963 23.1904912393177 all albu 17 6.13E-05 2.138501292 rs2190963 23.1904912393177 region-1 albu 17 7.11 E-05 2.615135135 rs2190963 23.1904912393177 peal albu 17 8.89E-05 2.138501292 rs7213403 23.8585458126516 peal complications 17 3.02E-04 1.316785454 rs2131432 3.09283706158732 region-3 albu 17 1.03E-05 1.616096579 rs17565276 31.2611298635719 region-1 stroke 17 4.48E-06 1.269788918 rs17565276 31.2611298635719 all stroke 17 1.68E-05 1.365656954 rs17588248 33.0061006676389 all albu 17 6.39E-05 0.866413519 rs17588248 33.0061006676389 region-1 albu 17 1.71E-04 0.7776633 rs3826366 35.7465929660504 peal complications 17 4.96E-04 0.748737556 rs9901549 35.7497038176454 peal complications 17 4.31 E-04 0.745817953 rs859232 40.5612373471126 region-3 complications 17 3.97E-05 0.534544708 rs859234 40.5650615222409 region-3 complications 17 7.25E-05 0.534638923 rs4514740 43.9667921019906 peal albu 17 3.25E-04 0.697610103 rs9908767 44.1283654389667 all albu 17 6.87E-06 0.669082126 rs9908767 44.1283654389667 peal albu 17 7.83E-06 0.669082126 rs2090018 44.158475109989 all albu 17 4.17E-05 0.699548026 rs2090018 44.158475109989 peal albu 17 4.55E-05 0.699548026 rs4985702 44.1892938684089 all albu 17 2.58E-05 0.69269103 rs4985702 44.1892938684089 peal albu 17 2.85E-05 0.69269103 rs1815568 48.0510174569966 peal mi 17 1.64E-04 1.329723934 rs11080063 49.4417674092892 region-3 stroke 17 7.52E-05 1.800124494 rs1123025 53.9677046690251 region-1 albu 17 5.22E-05 1.394746229 rs1123024 53.9677482745761 region-1 albu 17 6.35E-05 1.49382716 rs4239268 61.997824919925 all mi 17 8.49E-05 0.539634657

Page 51 Table LxIs

rs4239268 61.997824919925 peal mi 17 1.37E-04 0.539634657 rs1731901 63.1651764628642 region-1 albu 17 7.42E-05 0.720743437 rs1731906 63.1671864307801 region-1 albu 17 6.28E-05 0.719518893 rs16948951 69.7004393353469 all mi 17 8.20E-05 0.689367673 rs16948951 69.7004393353469 peal mi 17 8.71 E-05 0.689367673 rs16948981 69.7226771091988 all mi 17 9.88E-05 0.692925484 rs16948981 69.7226771091988 peal mi 17 1.04E-04 0.692925484 rs17682873 74.8108667148703 all mi 17 7.19E-05 1.238457636 rs17745322 74.8115749343173 all mi 17 5.89E-08 1.33085541 rs17745322 74.8115749343173 region-1 mi 17 3.27E-05 1.267553585 rs11868002 74.8136684109318 all mi 17 8.52E-09 1.374386694 rs11868002 74.8136684109318 region-1 mi 17 3.19E-06 1.326248409 rs2934921 74.8148913080742 all mi 17 4.13E-05 1.303172674 rs17818395 74.9413973652142 all albu 17 8.45E-05 0.708222472 rs17818395 74.9413973652142 peal albu 17 3.23E-04 0.708222472 rs8081285 78.4530089637003 peal stroke 17 3.90E-04 1.509190372 rs2203894 78.5130399592059 peal stroke 17 4.61 E-04 1.513742223 rs12603207 80.0525045368422 peal mi 17 4.27E-04 1.306597013 rs2021746 84.093132140787 peal stroke 17 2.96E-04 0.563678257 rs9900205 85.6137455290831 region-1 stroke 17 7.74E-05 1.616828027 rs2363246 85.7465683214126 peal complications 17 4.33E-04 0.786579477 rs12452883 90.033461764337 all mi 17 4.46E-07 0.375182424 rs12452883 90.033461764337 peal mi 17 2.14E-06 0.375182424 rs12452883 90.033461764337 region-1 mi 17 1.89E-04 0.398728814 rs7215208 93.9231965708785 region-1 mi 17 7.66E-05 1.30554503 rs7215208 93.9231965708785 region-1 complications 17 3.39E-04 1.277525565 rs11867831 95.5110866517932 peal complications 17 3.19E-04 0.766725569 rs12959798 0.581239431119211 region-3 stroke 18 4.22E-05 2.228571429 rs902581 101.886489048428 peal complications 18 1.58E-04 0.568899315 rs902581 101.886489048428 peal mi 18 2.05E-04 0.460075999 rs902581 101.886489048428 peal stroke 18 4.79E-04 0.34635149 rs11151403 103.416704180366 all mi 18 3.19E-05 1.363673565 rs11151403 103.416704180366 peal mi 18 4.99E-05 1.363673565 rs11151403 103.416704180366 region-1 mi 18 8.95E-05 1.437980826 rs17081619 105.051212873171 all mi 18 2.95E-06 0.457932264 rs17081619 105.051212873171 region-3 mi 18 2.96E-06 0.167076839 rs17081619 105.051212873171 peal mi 18 6.36E-06 0.457932264 rs8088357 107.880308119985 all stroke 18 4.81 E-05 1.529533414 rs8088357 107.880308119985 peal stroke 18 6.92E-05 1.529533414 rs12455599 107.881002914857 all stroke 18 6.13E-05 1.520301517 rs12455599 107.881002914857 peal stroke 18 9.02E-05 1.520301517 rs11151820 107.888183050428 peal stroke 18 2.76E-04 1.488910366 rs12454952 107.888341961581 all stroke 18 8.85E-05 1.51459825 rs12454952 107.888341961581 peal stroke 18 1.34E-04 1.51459825 rs7238329 107.907852719741 all mi 18 3.79E-05 0.05172511 rs1790866 110.712755334313 peal stroke 18 4.23E-04 0.578273344 rs7236071 111.003406124292 peal stroke 18 2.84E-04 0.587541982 rs12454775 113.524688213039 region-1 stroke 18 7.14E-05 1.21891566 rs1653157 115.203760104642 all stroke 18 4.35E-05 1.845671098 rs1653157 115.203760104642 peal stroke 18 1.05E-04 1.845671098 rs9954791 119.964023179194 region-1 stroke 18 4.08E-05 1.64476541

Page 52 Table 1.xls

rs4890773 119.968255107959 region-1 stroke 18 4.09E-05 1.640756653 rs11081564 125.040772609945 all complications 18 4.68E-05 1.390916315 rs11081564 125.040772609945 peal complications 18 6.08E-05 1.390916315 rs11081564 125.040772609945 all albu 18 4.34E-04 1.314778695 rs11663602 125.122402912385 peal complications 18 3.61 E-04 1.321334117 rs7236339 125.127256854819 all complications 18 9.83E-05 1.400550964 rs7236339 125.127256854819 peal complications 18 1.07E-04 1.400550964 rs7236339 125.127256854819 all albu 18 4.11 E-04 1.338350866 rs7236339 125.127256854819 peal albu 18 4.56E-04 1.338350866 rs7238071 125.127376515853 peal complications 18 2.53E-04 1.330709936 rs7238071 125.127376515853 peal albu 18 3.29E-04 1.311807091 rs9954459 25.03596845799 peal mi 18 2.34E-04 0.471745351 rs11873700 27.7734611836139 region-1 mi 18 5.62E-05 1.440014903 rs2124297 30.4864919242933 region-3 albu 18 2.75E-05 0.529305529 rs7228636 30.9653548992225 all complications 18 6.20E-05 0.588489629 rs7228636 30.9653548992225 peal complications 18 8.19E-05 0.588489629 rs8084083 39.6350532436922 all complications 18 7.02E-05 1.222980158 rs8084083 39.6350532436922 region-1 complications 18 4.20E-04 1.238585963 rs17619153 44.5250437956884 region-1 albu 18 8.29E-05 1.395969721 rs6508259 50.7247881743896 peal albu 18 1.14E-04 1.344805102 rs17187821 51.2635761691197 peal stroke 18 4.40E-04 2.804573805 rs6508322 51.3057044896159 all mi 18 1.19E-05 0.213146296 rs6508322 51.3057044896159 all stroke 18 5.49E-05 0.055472371 rs6508322 51.3057044896159 peal mi 18 6.84E-05 0.213146296 rs6508322 51.3057044896159 region-1 mi 18 4.47E-04 0.122172508 rs273770 51.9201321961689 region-3 complications 18 5.25E-05 1.483843742 rs273770 51.9201321961689 region-3 albu 18 2.58E-04 1.071748879 rs274231 51.920530112512 region-3 complications 18 8.03E-05 1.466231066 rs274231 51.920530112512 region-3 albu 18 1.87E-04 1.067347953 rs470455 52.4650855766638 peal albu 18 1.61 E-04 0.760352993 rs8097577 65.8061495477438 region-3 mi 18 5.76E-05 1.734329255 rs9951141 66.6597538841992 peal mi 18 1.89E-04 0.731828865 rs11082650 68.2017661312352 peal albu 18 4.38E-04 0.729171046 rs4940275 68.2077595753684 peal albu 18 4.05E-04 0.731477294 rs7243021 68.2115216788161 all complications 18 1.21E-05 0.738625999 rs7243021 68.2115216788161 peal complications 18 1.33E-05 0.738625999 rs7243021 68.2115216788161 all albu 18 2.01 E-04 0.771986223 rs7243021 68.2115216788161 peal albu 18 2.08E-04 0.771986223 rs7243021 68.2115216788161 region-1 albu 18 2.60E-04 0.746511628 rs7243021 68.2115216788161 region-1 complications 18 4.69E-04 0.772122819 rs8098626 68.222116752275 all complications 18 2.24E-06 0.718730554 rs8098626 68.222116752275 peal complications 18 2.53E-06 0.718730554 rs8098626 68.222116752275 all albu 18 4.32E-04 0.780744613 rs8098626 68.222116752275 peal albu 18 4.45E-04 0.780744613 rs7236575 69.1331623544964 peal complications 18 2.83E-04 1.454037583 rs17603170 77.0642966869264 region-3 complications 18 6.05E-05 0.509291339 rs8094838 79.0432261916302 peal mi 18 1.63E-04 1.430336411 rs10439056 81.5767641131722 peal mi 18 3.94E-04 1.650591243 rs9966194 82.7720006582261 region-3 complications 18 7.91 E-06 1.839244186 rs9947403 85.9584240739586 all complications 18 2.25E-05 1.226204546 rs639407 85.9596259970003 all complications 18 6.90E-05 1.21677445

Page 53 Table 1.xls

rs8089366 86.0392526980891 all complications 18 5.90E-05 1.208815207 rs7239405 88.1754229554847 region-1 complications 18 6.32E-05 1.380837359 rs1979787 88.2424168570517 region-1 complications 18 3.12E-05 1.400249018 rs980748 88.2894739652283 region-1 complications 18 6.45E-05 1.381847605 rs2332197 . 88.3331102155171 region-1 complications 18 8.17E-05 1.379584577 rs7505697 90.925274833063 peal mi 18 3.08E-04 0.76426277 rs10503076 94.6418206019211 peal albu 18 2.22E-04 0.458893617 rs7244113 94.6428668897368 peal albu 18 2.22E-04 0.458893617 rs6567316 94.6442348403607 peal albu 18 4.26E-04 0.47904411 rs12966869 94.6498515678577 peal albu 18 2.80E-04 0.464057348 rs17070627 94.6574831063511 peal albu 18 2.22E-04 0.458893617 rs1563734 94.6589076130731 peal albu 18 2.22E-04 0.458893617 rs8089273 94.7215399570122 peal albu 18 2.82E-04 0.474562798 rs3794970 104.863156287249 region-1 stroke 19 7.90E-06 1.435428006 rs11669127 104.918989178896 region-1 stroke 19 2.24E-06 1.38171875 rs2602707 17.6732382630741 all mi 19 4.92E-09 0.027834197 rs2602707 17.6732382630741 region-1 mi 19 2.45E-05 0 rs2602707 17.6732382630741 all stroke 19 4.18E-05 0.053940455 rs2602707 17.6732382630741 region-3 mi 19 1.32E-04 0.059761704 rs2602707 17.6732382630741 peal mi 19 3.24E-04 0.027834197 rs2913929 29.6557307441713 region-1 stroke 19 8.39E-05 1.195524146 rs3867196 48.356182165624 peal stroke 19 4.31 E-04 1.38412268 rs7255889 48.3568057404168 all stroke 19 9.11 E-05 0.720414977 rs7255889 48.3568057404168 region-1 stroke 19 4.63E-04 0.674897119 rs17759197 50.4128618537787 all mi 19 2.79E-05 1.200136933 rs17759197 50.4128618537787 region-1 mi 19 4.69E-04 1.257388623 rs1160217 50.7260930410011 region-3 complications 19 6.73E-05 0.454675884 rs8107919 50.9562660694919 peal mi 19 4.42E-04 1.375911118 rs16966238 54.4776873908578 all stroke 19 8.74E-05 1.194367614 rs284689 57.3457278857148 peal albu 19 2.74E-04 1.283705384 rs284688 57.3461656388547 peal albu 19 3.30E-04 1.281918511 rs12973797 58.7747686911762 all complications 19 6.91 E-06 0.705458046 rs12973797 58.7747686911762 peal complications 19 4.76E-05 0.705458046 rs7257383 61.5000465657252 all stroke 19 8.04E-05 1.374420227 rs7257383 61.5000465657252 peal stroke 19 4.62E-04 1.374420227 rs7245762 61.5001398968031 all stroke 19 9.24E-05 1.372933563 rs7245762 61.5001398968031 peal stroke 19 4.89E-04 1.372933563 rs12461941 61.9032226381711 all mi 19 5.09E-05 1.472839506 rs12461941 61.9032226381711 peal mi 19 5.75E-05 1.472839506 rs12981961 67.8803341486227 all complications 19 8.30E-05 0.840365558 rs10419078 78.166274595343 all complications 19 5.34E-06 0.998229819 rs10419078 78.166274595343 region-1 albu 19 2.51 E-05 1.133157063 rs10419078 78.166274595343 region-1 complications 19 1.32E-04 1.055107703 rs6510704 8.03228686331289 region-1 albu 19 1.98E-05 1.426693362 rs6510704 8.03228686331289 region-1 complications 19 4.48E-04 1.332257517 rs11666484 88.2192436932977 peal stroke 19 3.24E-04 0.67525196 rs13382085 97.3443983389675 all mi 19 1.58E-05 0.332974659 rs13382085 97.3443983389675 peal mi 19 4.29E-05 0.332974659 rs6129067 100.060157953169 region-3 stroke 20 1.63E-05 3.004 rs6129067 100.060157953169 all stroke 20 4.14E-04 1.842673308 rs4812276 100.072565108255 region-3 stroke 20 1.02E-05 3.096470588

Page 54 Table LxIs

rs2426990 100.122606928184 region-3 mi 20 4.04E-05 0.563443186 rs13040255 100.154222280163 region-3 mi 20 7.85E-05 0.576651111 rs1891490 100.156462491963 region-3 mi 20 3.05E-05 0.568250951 rs4347903 100.270449739455 region-3 mi 20 8.90E-05 0.534643893 rs6062419 103.632668158166 peal mi 20 1 -38E-04 0.666269368 rs6139427 11.940276880088 region-3 complications 20 3.89E-05 0.340911528 rs2423257 19.3849299470398 region-1 mi 20 3.52E-05 1.502347734 rs2423258 19.3854257769414 region-1 mi 20 2.09E-05 1.509145688 rs6055035 19.5587473388592 region-1 mi 20 6.08E-05 1.566502463 rs6038846 19.5611948396499 region-1 mi 20 6.62E-05 1.562774992 rs6117825 19.5758429208905 region-1 mi 20 4.69E-05 1.543624404 rs6055040 19.5770772208582 region-1 mi 20 6.68E-05 1.56462022 rs4501020 19.5876689915212 region-1 mi 20 6.86E-05 1.549893195 rs6086072 19.6275569246655 region-1 mi 20 2.16E-05 1.425406302 rs165558 32.8642216447586 all stroke 20 9.70E-05 0.918503515 rs16994496 33.7520196844607 all mi 20 2.05E-05 0.436507937 rs16994496 33.7520196844607 peal mi 20 4.39E-05 0.436507937 rs6105279 33.851985612444 all mi 20 3.48E-05 1.28296356 rs8115737 35.2316402540191 all albu 20 2.88E-05 0.402634672 rs8115737 35.2316402540191 peal albu 20 5.10E-05 0.402634672 rs2423942 35.8427561442918 region-3 stroke 20 5.67E-05 0.518029484 rs2058828 35.8973660147992 region-3 stroke 20 5.69E-05 0.519939205 rs1885574 38.6992948786853 peal mi 20 3.35E-04 0.68549183 rs13039735 38.7002909144068 peal mi 20 4.01 E-04 0.691800597 rs6136503 41.340976792055 peal albu 20 3.67E-04 1.451001287 rs6081676 43.0486401306747 peal albu 20 2.71 E-04 2.565100671 rs942989 43.0536664407268 peal albu 20 4.15E-04 2.460349462 rs6047186 45.8084670703842 region-3 complications 20 3.81 E-05 2.234116715 rs4141692 45.8133478929026 region-3 complications 20 7.15E-05 2.162044561 rs6049828 48.7784488289175 region-1 complications 20 4.88E-05 1.390894309 rs6049828 48.7784488289175 all complications 20 2.33E-04 1.288690013 rs6049828 48.7784488289175 peal complications 20 2.71 E-04 1.288690013 rs3764718 51.2526940807588 peal stroke 20 4.97E-04 1.436549901 rs4810777 51.2529331377626 peal stroke 20 4.29E-04 1.437581349 rs16988954 55.5606652602962 all mi 20 1.16E-07 0.145924439 rs16988954 55.5606652602962 peal mi 20 6.19E-06 0.145924439 rs16988954 55.5606652602962 region-3 mi 20 2.47E-05 0.087646653 rs16988954 55.5606652602962 region-3 stroke 20 1.36E-04 0 rs16988954 55.5606652602962 region-1 mi 20 1.82E-04 0.147257701 rs16988954 55.5606652602962 all stroke 20 2.08E-04 0.184716027 rs6065504 58.0689472999869 region-3 mi 20 5.12E-05 1.500099674 rs6016864 58.2478074167432 peal mi 20 2.76E-04 0.749621011 rs6072819 58.2501616058745 peal mi 20 1.81 E-04 0.741145136 rs6065525 58.2797801731932 peal mi 20 4.53E-04 0.743583383 rs2425520 58.281270960473 peal mi 20 4.46E-04 0.744076946 rs4810366 58.3005391619984 peal mi 20 4.68E-04 0.744490044 rs6093764 58.7005541360327 all mi 20 2.75E-05 0.377597135 rs6093764 58.7005541360327 all stroke 20 4.62E-05 0.233333333 rs6093764 58.7005541360327 peal mi 20 7.34E-05 0.377597135 rs6093764 58.7005541360327 peal stroke 20 2.35E-04 0.233333333 rs6093764 58.7005541360327 region-3 complications 20 2.45E-04 0.366035945

Paαe 55 Table 1.xls

rs6065603 59.2787824223222 peal stroke 20 2.77E-04 1.486702964 rs4812858 61.3224157665212 region-3 albu 20 8.06E-05 1.789195678 rs2425754 64.0794335452934 region-1 mi 20 4.19E-05 1.496135475 rs6018685 68.5226214644057 peal complications 20 2.33E-04 1.28676479 rs6095323 71.6050483383164 peal complications 20 4.54E-04 0.777687884 rs2426299 75.8494685513335 region-3 mi 20 5.17E-05 2.162377673 rs6021183 75.857108594105 region-3 mi 20 9.96E-05 2.088132022 rs13041126 77.7821372085946 region-1 mi 20 9.60E-05 1.388276336 rs6013694 79.5114243501226 region-1 stroke 20 3.29E-05 1.486974278 rs6013694 79.5114243501226 all stroke 20 7.81 E-05 1.353407937 rs204767 80.2409254111264 peal mi 20 4.75E-04 1.342520661 rs1370269 85.305543858019 peal stroke 20 2.31 E-04 0.642954602 rs10485801 85.3256590782382 peal stroke 20 4.05E-04 0.548374613 rs6014814 86.1414293811559 peal mi 20 2.98E-04 0.731331687 rs6069858 86.1426835160751 peal mi 20 2.38E-04 0.727518172 rs6069864 86.1450037167813 all mi 20 8.63E-05 0.711012161 rs6069864 86.1450037167813 peal mi 20 9.35E-05 0.711012161 rs6069864 86.1450037167813 region-1 mi 20 9.93E-05 0.651078247 rs4810081 86.9495675524995 all complications 20 5.33E-05 1.297632498 rs4810081 86.9495675524995 peal complications 20 2.19E-04 1.297632498 rs4810082 86.9495869726817 all complications 20 5.07E-05 1.297721675 rs4810082 86.9495869726817 peal complications 20 2.17E-04 1.297721675 rs9984988 11.1497287113447 all complications 21 1.33E-05 1.73143483 rs9984988 11.1497287113447 peal complications 21 1.71 E-05 1.73143483 rs4816801 11.1896678344806 peal complications 21 1.76E-04 1.601228 rs2407492 11.7316532064225 peal stroke 21 4.37E-04 1.545384782 rs2825891 11.8089817190317 region-3 stroke 21 5.77E-05 1.543843819 rs9976697 16.3401447727867 peal albu 21 3.22E-04 0.51093202 rs2027714 16.6651956364344 all mi 21 3.49E-05 0.564397835 rs2027714 16.6651956364344 peal mi 21 3.57E-04 0.564397835 rs200691 17.5134934078036 region-1 mi 21 9.60E-05 1.449219433 rs200700 17.5458456081431 region-1 mi 21 8.12E-05 0.710879548 rs2829267 19.6500421832421 all complications 21 9.45E-05 1.304395319 rs2829267 19.6500421832421 peal complications 21 9.84E-05 1.304395319 rs2829276 19.6523012934208 all complications 21 5.34E-05 1.315038638 rs2829276 19.6523012934208 peal complications 21 7.56E-05 1.315038638 rs988292 19.6584439438572 peal complications 21 2.95E-04 1.294690827 rs2248225 19.6611909095224 all complications 21 2.05E-05 1.334912282 rs2248225 19.6611909095224 peal complications 21 2.18E-05 1.334912282 rs2248225 19.6611909095224 region-3 complications 21 3.06E-04 1.559476309 rs2248339 19.6617349210361 peal complications 21 1.63E-04 1.291587674 rs2829290 19.6622543642879 peal complications 21 1.69E-04 1.291268462 rs11087943 19.8978376728801 peal mi 21 3.64E-04 1.328781072 rs2829819 20.1777204824915 all mi 21 1.87E-07 0.033682966 rs2829819 20.1777204824915 region-1 mi 21 2.46E-04 0 rs2829819 20.1777204824915 region-3 mi 21 4.50E-04 0.069072275 rs1444268 23.3331553369592 region-3 complications 21 1.42E-05 0.364592426 rs9977087 23.3657564051818 region-3 complications 21 5.65E-06 0.352455032 rs2831366 25.6225088934036 region-1 albu 21 3.00E-05 1.279890853 rs2210246 25.6406435160478 region-1 albu 21 5.86E-05 1.26346779 rs2831941 26.1622861823239 all complications 21 3.29E-05 1.199819506

Page 56 Table 1.xls

rs2831941 26.1622861823239 all albu 21 4.55E-05 1.252062816 rs2831941 26.1622861823239 region-1 complications 21 6.02E-05 1.163977278 rs2831941 26.1622861823239 region-1 albu 21 3.63E-04 1.279439547 rs2833256 28.3018431794761 all stroke 21 6.50E-05 2.052631579 rs2833256 28.3018431794761 peal stroke 21 1.00E-04 2.052631579 rs845022 29.9265654317093 all mi 21 2.84E-05 1.272374465 rs844986 29.935827304508 all mi 21 8.38E-05 1.259986224 rs2834136 30.4823010487636 peal stroke 21 4.28E-04 2.374660336 rs2252884 35.9816334194145 all stroke 21 9.23E-05 1.421416998 rs2252884 35.9816334194145 peal stroke 21 9.77E-05 1.421416998 rs1014994 38.3135719250834 all mi 21 2.40E-05 1.442427278 rs1014994 38.3135719250834 peal mi 21 2.64E-05 1.442427278 rs1014994 38.3135719250834 region-1 mi 21 8.33E-05 1.523681859 rs2836357 38.3347673059074 all mi 21 4.62E-05 1.347085539 rs2836357 38.3347673059074 region-1 mi 21 1.01E-04 1.432653061 rs2836357 38.3347673059074 peal mi 21 1.81E-04 1.347085539 rs2836365 38.3413858178174 all mi 21 4.28E-05 1.368026076 rs2836365 38.3413858178174 region-1 mi 21 4.93E-05 1.459075181 rs2836365 38.3413858178174 peal mi 21 8.32E-05 1.368026076 rs2836535 38.5862384730635 peal mi 21 2.88E-04 0.567028039 rs2836658 38.8144426113587 region-3 stroke 21 4.42E-05 1.732233503 rs2836658 38.8144426113587 all stroke 21 2.53E-04 1.422466741 rs2836658 38.8144426113587 peal stroke 21 2.97E-04 1.422466741 rs2837017 39.8248054184633 peal stroke 21 3.42E-04 0.646235029 rs2837018 39.8308192633384 peal stroke 21 1.80E-04 0.625349087 rs2065313 39.8414317367136 peal stroke 21 2.37E-04 0.632180417 rs1985220 4.39350921379208 region-1 mi 21 6.19E-05 1.3505895 rs1736010 4.39974677588291 region-1 mi 21 2.26E-05 1.370629371 rs10482872 4.44598875916705 all mi 21 1.08E-06 0.182101977 rs10482872 4.44598875916705 peal mi 21 1.41 E-05 0.182101977 rs10482872 4.44598875916705 region-1 mi 21 2.21 E-05 0.122695486 rs10482872 4.44598875916705 all stroke 21 4.43E-05 0.09558141 rs2837257 41.1035046372068 region-1 albu 21 9.33E-05 1.37204057 rs9305744 46.8218788329643 peal stroke 21 2.64E-04 1.447349369 rs2094881 46.8358082979859 peal stroke 21 3.09E-04 1.443761925 rs2839580 49.8362417456901 peal albu 21 3.48E-04 0.783120707 rs234787 50.6695653796478 all albu 21 5.35E-06 0.971711966 rs234787 50.6695653796478 region-1 albu 21 1.19E-05 0.954970146 rs234787 50.6695653796478 all complications 21 8.56E-05 0.936627793 rs234787 50.6695653796478 region-1 complications 21 2.17E-04 0.931862234 rs17004748 54.6193729100076 all mi 21 7.95E-05 0.419385493 rs17004748 54.6193729100076 peal mi 21 1.51E-04 0.419385493 rs17004748 54.6193729100076 region-1 mi 21 4.99E-04 0.315588934 rs9981276 57.5408391342541 region-1 stroke 21 1.38E-05 1.360383569 rs9981276 57.5408391342541 region-3 complications 21 7.08E-05 0.714984709 rs2824431 7.50106927880258 peal complications 21 4.35E-04 0.759299749 rs2824582 8.14816749566609 peal complications 21 3.95E-04 0.782599385 rs2824592 8.20814215732611 all complications 21 1.85E-05 1.274234694 rs2824592 8.20814215732611 region-1 complications 21 1.82E-04 1.251886872 rs741195 12.8032543100299 peal complications 22 3.86E-04 0.75141354 rs6004408 20.0478053732415 region-3 complications 22 8.40E-05 0.595451315

Paαe 57 Table 1.xls

rs5997780 28.8528346163207 region-1 stroke 22 8.82E-05 1.400941824 rs5749237 29.1970626034024 region-3 mi 22 3.63E-05 2.48608838 rs737809 29.2216446320994 region-3 mi 22 4.83E-06 2.684036394 rs5753560 29.2883845270357 region-3 mi 22 3.63E-05 2.48608838 rs16989635 29.4017971904628 region-3 mi 22 2.65E-05 3.098330241 rs16989682 29.448575476574 region-3 mi 22 5.17E-06 3.544368601 rs5994440 29.7757990308546 region-3 mi 22 1.17E-05 2.17015459 rs130250 31.0657277970264 region-1 complications 22 1.71E-05 0.687567514 rs130250 31.0657277970264 all complications 22 2.45E-04 0.764534582 rs585124 31.8787378486003 region-3 complications 22 2.46E-05 0.53809132 rs1489894 31.9095681126016 region-3 complications 22 2.73E-05 0.529282844 rs1489880 31.9197206548056 region-3 complications 22 2.35E-05 0.53909465 rs34479004 31.9334607452084 region-3 complications 22 2.73E-05 0.525808281 rs1873230 31.9357568491217 region-3 complications 22 2.39E-05 0.535414823 rs4821241 31.9360728602411 region-3 complications 22 2.73E-05 0.525808281 rs1844461 31.9437174066829 region-3 complications 22 1.69E-05 0.529847744 rs5754909 31.9484265203572 region-3 complications 22 2.39E-05 0.535414823 rs1489890 31.9510386353899 region-3 complications 22 2.39E-05 0.535414823 rs5749770 31.9649869643338 region-3 complications 22 1.68E-05 0.532074841 rs5749917 32.4590022476838 region-3 mi 22 5.32E-05 1.713191489 rs909565 32.4625629077353 region-3 mi 22 3.03E-05 1.732478284 rs4821283 32.4727789046653 region-3 mi 22 2.32E-05 1.93159261 rs5755254 32.5059146976591 region-3 mi 22 2.58E-05 1.787168142 rs5755255 32.5066816512253 region-3 mi 22 1.96E-05 1.796961022 rs17491531 48.0454905521709 peal complications 22 2.59E-04 1.514501953 rs16991714 48.9101715732011 all complications 22 5.18E-05 0.518607316 rs16991714 48.9101715732011 peal complications 22 6.68E-05 0.518607316 rs16991714 48.9101715732011 region-1 complications 22 3.83E-04 0.479905089 rs9614868 49.3983239144968 region-1 stroke 22 4.71 E-05 0.859422254 rs1894524 51.023964785875 region-3 mi 22 1.30E-05 0.418259936 rs5765398 52.537164070199 peal mi 22 4.83E-04 1.306272756 rs5765425 52.5522930828423 peal mi 22 1.74E-04 1.322823161 rs910771 55.2342124310271 region-3 complications 22 4.52E-07 1.699727171 rs17000687 61.5124905551577 region-3 stroke 22 1.41E-06 4.896103896 rs2858638 61.5703785717064 all albu 22 8.78E-05 0.690026788 rs2858638 61.5703785717064 peal albu 22 1.50E-04 0.690026788 rs2858638 61.5703785717064 all complications 22 3.99E-04 0.738131379 rs396012 7.39306493123289 region-1 albu 22 6.05E-05 0.668491845

Page 58 Table1.xls

TABLE 2

dbSNP RS ID Flank rsl3353636 TCTCACTCTCTGACTC[AZC]CCATTTTAATGAGCAA rs2055392 TTTTCTGTAGCAAGCA[A/C]CTGATCGTTCAGTAAA rsl0904908 AATTACTATGGCATAT[A/G]AAGTACTACAGCACGG rsl2346176 CTAAGAAATTTATTCC[CZT]CAATTAGGCAGCATTT rsl332845 CTCCTTTGGCAAAGAC[C/T]ACGAATTTTGACAAGA rs2252550 CTTTAGAACATG AGCG [A/T] AAATGG ATAG AAGTAG rsl0197403 GGATGGGCTCTATGAT[C/T]AGTCTCTAATGAGGTA rsll211590 GGCCCAGGAGACCCTA[A/G]ATCTTTGTATCTTTTC rsll230197 GGCCCATTAATCAAGA[G/T]ACCTGAAAGGCTTCCA rs2590681 GGCTGGGGCAAACAAA[CZT]ATCCTAGCAATTGGAG rsl0430114 GGGATCAGGAAGGTGG[GZT]ACTCTGTTTTTATGAG rsl6948951 GGGCCACATGCTGATA[CZG]GTGAGAGGCGGTGGGG rsl7266631 GGGCTAGGGTTTCCTG[C/T]AGTATGCAATAACATT rsl0866247 GGGCTCTCAGCCTTTA[C/T]GCTGTGAAACAAAGAC rsl3230952 GGGGCCATGGAACAAG[G/T]CATTTAGCTAATAACT rsl2425397 GGGGGTCCAGTTTCTA[C/G]GTAGATGAAGGAACTA rsl7796864 GGGGTTAAACAGGCAG[C/T]CATCTTTTAATGCGAT rsllO81564 GGGGmCCTCATCAA[AZG]TCCAAGGCCATTTCCC rsl507216 GGGTAAAGATAGGTCA[CZG]ATGAAGTAATCTCCGC rsl0012953 GGGTATrTCTCTGCTA[C/T]GTπTATTTGTGAAAA rsl0954447 GGGTCTCCACTTTCAC[C/T]GGGACTCAAACCCCCT rsl0979779 GGGTGAGGTGGAAAGC[A/G]GACTGTAGCATTTACT rsllO66945 GGTACTTTTGTAAAGG[CZT]ATTTGATATGGTTTGT rslll51403 GGTAGATCTGAAGGCA[A/T]TGATATGAGGTCTCAC rsl6994496 GGTTAACTTCTTTTCA[A/G]TACAGATGGTTTAAAA rsl526591 GGTTTGTGTGTACTTA[G/T]CTAATTTTTAAAGAAG rslll39946 GTAAAGCTTGGCCACA[A/G]GTCAATGGGGGAAGGA rsl6919323 GTAAATGAAGTTTAACIA/GIGGAACATGATCACACC rs2096148 GTAAATGACACAACAC[A/G]AACAACCAGTAAAGAA rsl7600042 GTAAATGTTTCGAGTA[C/T]GTTATTGGGCTCCATT rs2265423 GTAACTATAGmACA[AZG]TAAGCCATTTTACCTT rsl678009 GTAAGAAACTGACCTA[C/T]GGATTCAATGCTATCC rsl7775330 GTTTTCTGGAAACCCA[AZG]TAAAGGAACAGATCTT rsl061860 GTAATTGTCCTCAAAT[C/T]AGAGAACACTGGGTGG rslO272911 GTACTAGAGCTGGTAA[A/G]CAACAGAGGAGTACAG rsll23025 GTACTGGGATGAAAAC[A/G]GATGGCCCCTACTCTT rsll233277 GTAGAGATGCTTAAAAtC/TlTGATGAATCAAGAGAT rslll85172 GTAGCCGTTAAGCTCC[AZG]CAAATCACATTTAATC rsl0804636 GTAGGCAATTGTAACA[AZG]AAATGGCATTTGTGTA rs2423942 GTATCCTTGGTCGTAA[CZT]CTAACAGAAGCTAATA rsl7477680 GTATGAACATTTGACA[CZT]TGTAACCTATTACTAT rsl7124218 GTATTAGAGGTAGAAA[CZT]TTGAGATTCATTATCC

rsl569255 GTCAAGGTCTCTTTCC[C/T]CATGAAGATGTAATTT rs2602707 GTCAGGGGTTCTCAAA[C/T]GGATTTCAGGACCCTT rsl0115131 GTCCCTTCCTATTAAA[A/G] CACCTAACACAaAG G rsl6861123 GTCTAGCATTCCATTA[A/G]ATTTGTACGTGTATTT rsl558993 GTCTCACCAGGTCTAC[A/G]CTCTGCTATTCAAAGA rsll563175 GTCTCAGGATTACATAIA/GIGAATTTAGGAAATTTG rsl2443955 GTCTCAGTCTCTAGAC[C/G]AGGTATTCTCAGATTC rsl811442 GTCTCCATTAGATCAT[C/T]AGGTGACAGTAATAGT rsl0947854 GTCTTATAATGGGAAC[A/G]GACCACTTGACAGTAC rsl7601491 GTCTTCCTTGTTCCAA[C/T]TGAAGATATAAATTGC rsl3263794 GTG ACCTTG AAAAATG [A/G] AAGG AGG ACATCTTCC rsl30250 GTGATGGTTGGAGAAA[C/T]GGGCACCTGGCTTTAA rsl7832528 GTGCCACGGATTTGAA[A/C]ATAAACTTGAAAATCA rsl0829973 GTGCCTCTTTCAGGTAtC/T]GTTTGTCAGGGGAGGT rsl7064029 GTGCTTAAACATATAC[A/G]ACGCATTAAATGAAGC rsl254947 GTGCTTGCTGTCTCCA[C/T]TAGTAATATGTCTATA rsl7027538 GTGaτrGCTTTAGAT[C/G]ACTGGTTTGTTTCTAT rsl865977 GTGGTAAGATCTGACAIG/TJTCAAGAAAGCAACCAA rsl7725010 GTGGTATACAGCTTTA[C/T]AGACAACCACTACCTC rsl0947863 GTGTGATCTTAAACTC[A/T]ACAGCTTAGAGGTGCC rsl7609346 GTTCATATGCCCTGCC[C/T]GGACTCTAACAGGCTA rsl6867595 GTTCTAAAGGAAGGGA[A/T]CTGGGCAAAAACTGAA rsl331484 GTTGAAGATGTCATGC[A/G]ATGTCAACCTGGAGTT rsl0094168 GTTGAGCATGTTTACC[A/T]ACACACAGCACCCCGG rsll645904 GTTGGATGCTTCATCC[C/T]CGATGCTACAGTGTTG rsl3039735 GTTTAATTCTCAGACC[A/G]AACACCAGAACCTAGG rsl929751 GTTTCAGAAGCTTCCA[A/G]TCACTGACCAATTATT rsl295133 GTTTGTATCAGTACTA[C/T]GCAGTTCTTTTCTCTT rsl524966 GTTTGTCAGAAGTGAC[A/G]CATTATGAGGGGATGC rsl0202400 GTTTTCAGAACTCTAC[C/T]AAATCTCCCAGCACCA rsl0956801 GTTTTGTGGTTAAAGG [A/G] ACATGTTAGAGGAAAT rs2035930 G I I I I I GCATTCCTAA[A/G]GACGAAAATTCTTTAA rslO836616 TAAAAATACTTAAGCC[A/T]CTTAACTATAAACATC rsl401209 TAAAACAATTAATGGC[A/C]ACAAAGACTAGGAGGC rsl87994 TAAAGAGTGAAAACCCIA/GJAAGTAGAGAAACAATA rsl7770992 TAAATAGAGTACACAA[C/T]AGGTTCCTTGTCTTCA rsl6941252 TAAATCAAGTGTTTAA[A/G]GAGGGACATTCACGTC rsl0972788 TAAATCTTTCCAGACA[C/T]CAAAGTAGACTCTCTC rsl3375397 TAAATGTCAATTCAAA[A/G]TTCAGGAAGTTCACCA rsl537583 TAACTGTACATACATA[A/G]CAGGCCAAAATCATAG rsl3166738 TAAG AG AATG AATGTC[C/T]AGCCAACCACTGG ATT rslOO9593O TAAGATCCCACAGTCAIC/TJTAGGAGCAGAATCAAT rslO25991O TAAGCTGCAATTCTTA[G/T]GTGCTTTAGAGTGTAA rsl7531334 TAAGTAGGATTCCATA[C/G]GTAAAAATAACCCACT rsl2403445 TAATAGCCATCATACC[A/G]GGGGAAAAGAGAAGTG rsl6845844 TAATCACCAAAAATAA[C/T]GATGACCAGAATTTTC

rsl0828424 TAATCCGATTTCATCA[A/G]CTCACACTAATCACTA rsl295890 TAATCTCATGCTTACA[A/G]AAGAGTTGCAAAAATA rsl546240 TAATG AAAGCACCAGG [A/T] C ACTCTC AT AAATATG rsl0894967 TAATGGCTTGAGCTTC[C/G]AAATTGCTGAAGGGTT rsl6908422 TACAAATATTGAACAA[G/T]TGAAAAGGTCACAGAT rslO161196 TACAGGCAAATGAGAG[A/G]CTATTACTCACCACAA rsl6915836 TACATCTTTACCTAAA[A/G]TGATTAACAAGTAGCC rsl844461 TACTCTGGAGATAGGA[A/G]A I I I I I L I I GATCAAG rsl6937197 TACTTCTGAAGCATGA[C/T]GCTAGAGTGGAAAGAA rsl699001 TACTTGGGAGCGAGGAIA/GITATTGGAGACAGGGAA rsl2541202 TAGAAATGTGCTCTTA[C/T]GGTTTTTGCTATTTGT rsl0824696 TAGAACCTTTAAGCCA[A/G]TCGTTTGACAGCTGTG rsl3431095 TAGAGAACCTGGCAAA[C/T]TGACCAAGCACCACTA rsl2959798 TAGAGGTTATGACCAC[C/T]GAACTAAGAGACCAGA rsl637931 TAGAGTGAGGATTAAC[A/G]GAGAGCCAGGTGCCTG rsl7218334 TAG ATTG ATGTTGCTA[C/T]CATATAATTTCCAATT rsl2213227 TAGCACACATTTCTTA[C/T] ACATAGTTCCTACCAG rsl7565276 AATTCTGGGGAAACAA[A/C]CTGACCTCTTCATTTG rsl6975959 TAGCCCAACGGATATC[A/C]ATGAAATACTTTGCTT rsll082650 TAGGAAGTTTACAAAClA/GlAATGAGAAAAATGAGT rsllll9552 TAGGAGACAAAATAGA[C/T]GATGATCAAGGAATCC rs2163635 TAGGCAGCACTGATCC[A/G]AGGTGACAGACCCCAG rsl416079 TAGGTAGATTCTGGTAlA/GlATAGCTGGGAACTATT rsl7094380 TAGGTCAAGGTCACTA[AZG]GTAAATAATAATACAT rsll023705 TAGTGATAGTCCTATC[C/G]AAGAGTTCAAATGGTC rsl815568 TTCAACAAGTTAGTGA[C/T]GTAGAATAAATACAAT rsl7021814 TATATTAGTGACACTA[C/T]CTTGATCAAATTGTAA rsl2814669 TATCATCAGCTACACC[A/G]AACACTCAAGTGTAGC rs2627531 TATGCTTCACACTTTC[A/C]AAATTTCTACTACACG rsllO18633 TATGCTTGCAAGTGGA[AZT]AAATAGGGTACAGAAA rs2630728 TATGTG ATTTGGACTG [A/T] AACTG CATCAG GAAAA rslll89836 TATGTTCTCTACAGTC[A/G]AATTAAATGAAGAAGA rsl528858 TATTATAAAAGCCTCC[C/T]AGTTGGTGTCCTTGAT rsl2647173 TATTTCACAATGCCTC[A/G]ACCTGAAGAATGCTAT rsl0836620 TATTTGCCAAAGCCCA[A/T]GTCGAGAAGGGAAATT rsl0248275 TATTTTTCGTTTTCAG[A/G]ACATTCAGTTGGTATG rsl3231053 TCAAAAGACGTGCAAA[A/T]CACCCCAAAATCGTTG rsl2764197 TCAACTAATTTTACAA[A/G]CCAGTAATCTGACTAT rsll073505 TCACTTATACCTCAGA[A/C]ATGAAAGCAGCACCCA rsl2271990 TCAGATAAACAATGAA[C/T]GACATTTTCGTATAAG rsl7802054 TCAGATCAAAAGATGC[CZG]AACGTGCTGTAATGCC rsl0766122 TCAGATCCTAACTTAC[A/G]AGGTGTGTGAGCTAGC rsl7654227 TCATAGAGATGTTTAC[A/G]ATTTGGAAAACTATCC rsl7024129 TCATATGCCAAGACAG[AZC]AAAAGAACCGCAATGA rslO466917 TCATGGCTGTGATAAC[G/T]GTCATTATTTTGTTCC rsl7042372 TCATTCATTTCCTCTAIC/TlGTGATTTGGAGCCCTT

rsll046650 TCCAACAGAAGAAACA[A/G]CAGAACTGCTTAAGGC rsl2603207 CTTCCACACTTTGAGC[A/G]CATTCACTCTGCAGTT rsl0904339 TCCATAGACTTGCATC[A/G]AGAGAAGAAGGAGAGG rs2277924 TCCCAAGCTTGCTCCC[A/T]CTCCTGTGCAGGCCAT rsll080063 TCCCATGACCCACTAA[A/G]TATGGATCCCAACACT rs2221440 TCCCATGCCTCACATA[C/T]CTCCAAGGGGCTCTGT rsl3072632 TCCCATTGACTTTGAC[C/T]GGAGACATTTATAGGG rsl65558 TCCTATCTCAAGACAA[A/G]GAGCTGCTTCCAAGAA rsl028932 TCCTCCTACATGATTA[C/G]CAGGTTTGAATmTG rs2332197 TCCTG AACAGATATGA[C/T]GATTGTTCTGCCTTAA rs2406853 TCCTGAAGATTCTGAA[A/C]TATTCCAAAGGATTAG rsl7806588 TCCTTAAGCAGAATAA[C/T]ATCAGATCAAGTGTAC rsl438698 TCCTTATGAGCCTTGC[A/G]GACAAAGAGGTATCCT rsl0760419 TCCTTGACCTGCTTAA[A/G]TCTGGCTTC I I I I I CC rslO921262 TCCTTGTAGGTCTTTA[A/C]GGAGTCTCCACACTGT rslO199478 TCCTTTTTGTCTTAAA[C/T]TCTGTTTGAATGCTCT rsll784552 TCGATTGTGTTGCATGtA/GlATTTGTGCAATATAAA rslO743140 TCGTAGCCCTCATAAA[A/G]TCATAGTGCAATGCAT rs248528 TCTAAATTAATCCTTG [A/C] AATCCTATG AGGTAGG rsl2156376 TCTAACAGATTTTACA[A/G]TGACTAGCTTAAGACA rs2021746 TCTAACTAGTCGGTGG [A/T] AAGACGTCCAGTCATC rsl6955918 TCTACTGTTGACAGGA[C/T]TCCAGAGTAAAGAATC rs2027504 TCTAGTTTCCTTTTCA[A/G]TCCAGCAAAGTCCTTT rslll93235 TCTATTAAAAAGGTAG[C/T]CTAAGCTGAGCTGGGG rs2433285 TCTCACTCCCAAGTAAlC/TlCACTATTCTCATTTCC rsl3353636 TCTCACTCTCTGACTC[A/C]CCATTTTAATGAGCAA rsl0863213 TCTCTCCAAACCATTA[A/G]G ACCCCTCTTCTCCCA rsll641790 TCTGATCGACGCTACA[A/G]TGAGGATGAACCTTGA rsllO65172 TCTGGGTTCAAATTCA[A/G]GTTGTCCTCTGCCCCT rsl349 TCTGGTAAGAATTTCA[C/G]AATTCCAGGACGTCTC rsll736052 TCTGTCAGGATCAGAC[A/G]ATGCACGGTAAACGTC rsl7007502 TCTGTGTGTGTAAATGIA/GlAGGCCTTTTCCCTTGT rsl2454775 TCrTGCTAmGCCGA[C/T]ATTGCTAAGGCTTTGT rsl7745322 TCTTTGCTTCTTAGGA[A/G]CAGGATAATTGATTTG rsl540899 TGAAAGAGTGCTCTGA[C/G]AGATTAGGAGTGCATC rsl7005998 TGAAGAGTTGAGATAAIC/GJAGACAAGAACGAGAAA rsll057690 TGAAGCAGCCACAAGA[A/G]TCTAAACTGTAAGAAC rsl7099254 TGAATCAACAACTGAC[C/T]GTATAAAACTATGCTT rsl956517 TGACAATATTGCCAAG[C/G]CTTGCTACTGAAATGT rslO259713 TGACTTAATGAGTAGCIA/GlAATGTGACCAAGAGGT rsll839567 TGAGAGACGGCCATGA[C/T]GTAACCAACCAGGGGT rsl728200 TGAGGTGTAATCTAAC[C/T]AGTAGACAAATGGCAT rsl370269 TGAGTATCACTACATA[A/T]CTGGCTGTAGCAACGT rsl2892499 TGAGTCCTAAAGAGCA[CZG]TATTTCACGATTTGGC rsll242144 TGAGTTCCAGAAGGCA[C/T]GACAGAAGGTTCTGGG rslO934167 TGATAAAAGACTCTTG[A/G]AAGGACTAGTCTCATA

rsl7353566 TGATTCAαCCAGGCA[C/T]GAATATTCTTCCTTTC rsl0234057 TGCAAAGGAGAAATGAfA/GJGGACACAATAAGAAAA rslOO25265 TGCACACAACACAGGC[A/G]AGGTAGTAATATTTAG rsl770221 TGCAGTTACTTTGGAA[A/G]TCAATTCTGCAATTTC rs2555607 TGCCCTTGAGATCCCC[A/G]CATATCAGGCATGTGA rsl2860641 TGCGTGTCTCTCTCCA[C/T]TCCCAACTAAACCCAA rs2261485 TGCTAAGCTTTTATAA[A/G]TGATGTCCTCTTATCA rs2209543 TGCTAGATGATAGCAA[C/T]TGATTTTGGAGCAACA rs2404273 TGCTAGTAGGAAGGGA[C/G]ATAAGTACAGCACTTT rsl0878017 TGCTAGTATTGTTCAA[A/G]TCTATATCCTTACTGT rsl2657171 TGCTGAGTGAACACAA[A/G]CAGTAACCTATGTTCT rsllO87943 TGCTGTATATTTGACA[A/C]TGAATGACTGTCATCT rslO743138 TGCTGTCTCTAAATTA[A/C]AGCTCTGTTTCCTGGG rsl993981 TGCTTGAATACTGCTA[A/C]AGATAAAAATGGCAAA rsl61455 TGGAAACAAAAGCTGT[A/G]AAATAAATTCTGCCCC rsl0186021 TGGAAATCATATTGAG[A/T]CACTACCAAGATGGGC rsl2641411 TGGAACGTAGTTAGGqA/GJCATTAGTCATGAGATA rsl0751020 TGGAAGCCATGATGCC[A/G]ATTAGCTAACACCAGA rs2265800 TGGAATGACGTCAGAAIC/TJGTGTTGAGAATTTGGG rsl2474795 TGG ACAAAAG AGAG AG [A/TJATAGGCGTGTATCATA rsl3040255 TGGACAGCTTTGAAGA[A/G]CACTGGAGAGCGACGT rs2143300 TGGAGCTTCCTACTCAIC/TIGTTGATTTATGTCTCA rs2572318 TGGATCTTGTTGTTAC[C/T]ATGGATGACATTTGTC rsl7745212 TGGCAAGACCTTAGCA[A/G]TGATTAAAAGGTACTT rsl94168 TGGCAGACAGTTTGAA[A/G]GCCCAACAAAAATGTG rsl7078168 TGGCTCATACTCACCA[A/G]GCTGTGTCCAGAGTCT rsl568272 TGGCTTTGATAATTCC[C/T]AGGTTCTCCATAAATC rsl498599 TGGGGTTTATGGAAGC[A/G]CCAAAACATGATGTAG rsl7099196 TGGTCTGAGGCAGTTT[AZC]AAAATTGAGAGACAGT rsll850956 TGGTGATGAAGCCAGAIA/GJCGTAAACAGAATGATT rsl7362459 TGGTGGGTTCCACCTC[A/G]ATTGCCAACTTTTTAG rsl444309 TGGTTAACCAAGATAA[C/T]TGTTGCCTCTATTTGG rsl501501 TGGTTTTGGAGAAGGAfA/GJGATGGCTAGGAACTAA rs2452463 TGGTTTTGTACTTTCA[C/T]GTTCAATTCCATTGAC rs208591 TGTAACACAGGTATGA[C/T]AATTTTGGACACAGCT rs2352906 TGTAAGCATCAGGTAAlC/TlTCATTCGAAAGCTAGA rsl2450896 TGTACACTGAAGAATA[C/T]AGAAGGCAGCTGGGCC rsl339881 TGTACATAGATGAAAC[A/C]CACCAATTAAAACGCA rs2400141 TGTAGTTATCACTCAA[C/T]TTAGCCAATTATATCT rsll666484 TGTCGGATTTTAGGAG[C/G]CTCACTACAGAGGGCA rsll641090 TGTCTCCAAAATAAAA[A/C]TAACTAGGCACAGTGG rsl7345528 TGTCTCCTTGCCGTTA[A/C]AAGAAAGTAGTGCTGT rsl647966 TGTCTTGTATCTCTTG [C/T] AGG ATGTATTAGTCAG rsl7044494 TGTGATAAAATTCTAT[C/G]AACCCAGAAATCACAT rsl7437560 TGTGCAGTGGATTTCC[A/G]GAAAATGTTGTCTTTT rsll637964 TGTGCATCATGGTACC[A/C]CAACGATGAAAGTCAA

rsl7449243 TGTGGAAAGCAGATGA[C/T]GATTACACTGTTAAGA rsl405164 TGTGGATATATGAAGT[G/T]AATGTAGTGACTTATT rsl7050187 TGTGGTTGATGGATAAIA/GJTTAGCCAGTTAGAGGC rsl7121574 TGTTACCAATGCTGAA[C/G]TCTTGCTTAATTGATA rsl363697 TGTTATAAACTGCAAA[A/G]CTAAAAGATAGCAGAG rsl7585174 TGTTTAGAGCTTCTCC[A/G]AGGACTTAAAATGAGA rs2481628 TTAAATAAGCCTTACA[C/T]AAAAAACTATCAACAA rsl203375 TTAAATGGCACAGTAA[A/G]TACAAGCTAAGGAAGG rsl7347351 TTAAATGGCCCTCAAA[A/G]GATACTCCTCTTACAA rslll97169 TTAACATCGAAACATG[G/T]AAGTCTCAGTTACACA rslO29969 TTAAGTCACTTGCCCA[A/G]GATTATTCAGGACGTA rsl6866776 TTACGTGCTCCCACGA[C/T]GGTATCTGCCATACAT rsl7750253 TTACTACTAAATAAAA[C/T]GTCGTAATGAAATTCA rsl0813889 TTAGAGGTATGACATA[A/G]ATGTTCTCTTTCACTC rsl7362494 TTAGCTATTTCCATCA[C/T]GGGAGAAAATGACATC rsl7081709 TTATAGAAGCAATTGA[C/T]ACATTTGGAAAAATCA rsl7070627 TTATCTCTCCAAACTG [C/T] ATTTCATTTTAGCAGT rsl7094227 TTATTAGGGATACAAGIA/GJCCAAAATAGAAAAATA rsl6822521 TTATTTCCAGTAAAAA[C/G]AAGGCATAGAAATTCC rsl7776629 TTCATGTTCAATCTCA[A/G]GTAGGACACAGCCTGT rsllO19O31 TTCCAATCAGTAGCCA[C/T]ATTTGGTCCTCATAGG rsl0189482 TTCCTAGTTATGCAGG[A/G]AATTAATTCGGGGGAC rsll259112 TTCCTTTCTTCATTCA[A/G]TAAACATCCACGGAGC rsl7066499 TTCTATGCATCTTTCA[A/G]GACGTAACCCAAATTT rsl402337 TTCTGATTATCTGGGA[G/T]AGTGAAGAACTCCAGA rs2075402 TTCTGCATCTCGGAAA[C/T]GGCCTATCTTCTTAAG rsl6984512 TTCTTCAAAGGCTTCA[C/G]ATAAATTAAGACATAA rsl7303597 TTGAGCAAATCTTTTA[C/T]GGCAGTTTTCCTCATA rs2363683 TTGCCGTCCACAGCAG[G/T]CTACTGACGAAAAACG rsl0208883 TTGCTTCCTGTAAAAA[C/T]TTATACTGTACAGTTA rsl495977 TTGGAGTGCAGCTACA[A/G]GAACCCGGTTCACTGC rsl7165007 TTGGAGTTCCATAGCA[C/T]GATAATπTCAGTTTT rsl7759197 TTGGCTTTCTGTTGAA[G/T]ACATCATTTGTGGAAT rsl464611 TTGTAATGGTTGTTTC[C/T]CATTCCGGTTGTTTAT rsl569256 TTGTCAATTTTAGAGAtC/TlGTTAGATGAATTTAGT rsl490239 TTGTGAGATCTCCTAA[C/G]TCAGATTCTAAATCTC rsl731906 TTTAAAGTGG AAGGG A[C/T]TCCAAGGTTCGCCTCA rsl2173424 TTTAAGTTGCAAAACC[A/G]AAAAGTATGTTACTGA rsl6889712 TTTAGAAACCATGAGA[A/G]GTGAGCATCAGTGGAG rsll254057 TTTAGACATGACACAC[G/T]GTATATGAAAAAGGAC rslO841978 TTTAGGTCTTGGCTCA[A/G]ATGAAAGCTCCTCATA rsl0070447 TTTATACACAGATCCA[C/T]GAGGAAGCTGCCTCTT rslOO83736 TTTATGACCATGAATA[C/T]CTATTGTTTAGCTCCC rsll258843 TTTATGGGAGGATGAAIA/TJTCAGTATAAAGATAGC rs2030078 TTTCAAAGACCTGATA[C/G]TAACTAGAGAAAGACA rsl3279285 mCAAATGGTGTGCC[A/G]AAGTTTTTGAAGGAGA

rs2193257 TTTCCATAGGCTTCTC[C/T]ACCGTTCTACATCTAT rsl215665 TTTCGGCAGCCTCCCC[C/T]AGCTGATCATCATGTA rsl3435843 TTTGAAACGTAACTTG[A/G]AAGGGCTTTGAAATGC rsl7743255 ^" πTGATGAAAAATTTC[C/G]ACTAAGCGTGCTGGCA rsl2530533 TTTGCAATAGCTACAA[C/T]GGTTATAAAATACTTA rsll235074 TTTGCTCTAGAAATAC[A/G]AAAGATGTCTCTTAGA rsl7205999 TTTGG ATGCTAATCTGIA/G] ACTGTGGTG ACTGCAC rsl7362438 TTTGTAGTCTTAGAAC[C/T]AGGATGCTTTACATTT rsl7427286 TTTGTCAAGAAATCCA[A/G]TAATACATCAGCGACG rsll843348 TTTGTTGTTGTTCAAA[C/T]TATTAACTCTTAGCTC rsl476581 TTTGTTTGGAAGCTCC[A/G]GCCTAGAGTGAAGATT rs2070949 TTTTAACAAGGCCATG[A/T]ATTAAATATGGAAGGC rsl878840 TTTTCAGACATTCTTC[A/G]CAAAAAACACTGAACA rsl7117789 TTTTGGATGAGAGCTG[CZG]ATAATTTCCCAAAATT rs2058828 TTTTTATTTGAαTTC[A/G]ATTGTGATTTTCTTTT rsl3070811 TTTTTCATCTGTTTCA[A/G]GACAATTTGTAACTGC rsl213578 AGTAG ATCG ACAGTCC[C/T] ATCATTTTG AAGGTCA rsl0495829 CCAAAACTCTTACCAC[A/G]GCATGCAAATGTCTTC rsl560260 GGGAACAAGGTAATAA[C/T]TGCTCCTCTCTATCCA rsl560258 AATATGCTGGAAAAAA[GZT]CTATTATGATGCTGTA rsl6830446 TTTAGCTGTCAAGCTC[A/G]CTGGTCATCTTTCCCT rsl0497220 CTGTTTGCACAGAATC[C/T]AATTTTGGTGTATTTA rsl6863394 TCTTGAAATCAAATGC[A/G]ATGCTTACTGCTGAAA rsl402108 CTGTGCACAACCTGCC[AZC]CTTTAAAAACACATAT rsl2987074 ATGCCAGGCACTTACA[C/T]ATCTTACATAGAAGCA rsl6854563 GCTGTAGCAGGCATTG[A/G]ACTCACTGGCCTAGTG rsl6825771 TGTAGGCAGTGAAAAA[C/T]GCTCCCTAGTTTTATT rs2425520 AGTATGTACTTAAGCT[C/G]AAGTCTCATCATTGAT rs2027714 ATAGGAATTTGTCTAT[A/G]AAGAAATCACTGTATA rs200691 TTAAACAATGGATAAA[A/T]ATCTGGGCCGAGCACG rs2210246 GACAGAAGAAAACCAC[A/G]GTATTATATACACAAT rsl489880 TTGCCAAGCCATAATA[C/T]AGGATCCTGAAAAGAC rsl6991714 ACTTTAGTTTTTGCCA[A/G]CTGCATATGGAATGGA rsl7606712 GAAAAAAATCTCAAGCtA/G]GCAATATAGTCATTCC rs2205895 ATCTCTAACTGGTGAT[A/G]AAGCATCATGAAATTC rsl61905 TACAATATCTTGTGCA[C/T]AGCTACCTGCCTGTAG rsll708202 GTATCTCAGAGTCTAA[C/T]GTGAGCCTGTTTCCCG rs2035558 GCCTTTGATGAACTCA[C/T]GAGCTAGTTAGGTGAG rs2035559 TGCAGTAAGACAAACAIG/TITATCTTAGGGGACACA rsl552620 CAAGGGGATATTGAAA[GZT]CTATAAGGATGAATCA rsl3067150 CTAGCAGAAATGCCAA[AZG]TCTTTGGGTCAGAGTT rs2317750 GGCACTATGACTAAAA[A/C]AATGCACATCCCCTAA rsl2496159 ATACTTAAAATCACAGIA/CIAAGTTAGAGACTGAAA rs2317703 TGTTATTGATGTGTAG[AZG]AATTCTTTGTATAATA rsl0511345 GGTTGCAATAAAAGAA[CZG]TGATGGCAAATGGACC rsl7753899 GGCATCTTAGCCCTCA[CZT]GCCGTCTGGTGGGTGG

rsl7368784 AATTTAGGCAACTGAA[A/G]TGATTTAACAAATACT rsl6855137 AGAGTTTGTCACAAAGIA/GJAAATGTTCAATGTTGG rs2191003 GTAGTTGCTACCAACA[A/G]AAATTTCCACAGTGAT rsl450900 CTTATGATTGGCTTCA[C/T]AGCCTTACACTCAGTT rsl2504640 TCACACTGGGATGGAA[C/T]TATGGAACCTATGCCC rslO518199 TTCCTCCACTTGAGGA[C/T]CTTGTTGTTAGAGTTG rsl933711 TCACTTCTCATGATGC[A/G]GATTTTGATGCAATTT rsl376088 AACATTCTGTACCTGA[C/T]GTCCAAAAAACAAAGA rsll736202 GGAAGCAAGATCAACC[A/G]CAG ^" πTGCCCGGGCAT rsl0017958 CATAAAACATGGATGAIC/ηGTATAAGTTGATATTT rsl836655 TGTCTTAACTTCACCC[A/G]ACTTCAGGCATTTATA rsl435495 GGTAGTAGGGCAATGGfC/TJATTATGGCAGAAGGTG rs2034877 CAAAATCCAGATTACA[A/G]ATTGGATGTGGTATTA rsl498600 GGTGCCAAGCTAGTCA[A/G]TCAGTGGCAAAGCTCA rs2125143 TCTCAGCTGTGATAAA[G/T]TGACATGAGCTAGATA rsl3436111 ACCAAGAAAATCAACA[A/G]TGAGACCATCAATTTA rsl461237 AAGTGTATTTACCATCtA/GlAGTTATAAAG CTTTTC rs2116732 CGCAGGCTGTGCTTTG[C/T]AAGGGGTTGATAGAAT rsl0484953 TTTAAGCTTGGAGACAtC/T]CCTGTTAATTTATTTA rsl202201 CTTCTTGACAACTCTC[A/G]ATGTGCTACTGAGAAA rs2066951 TGCAGCAGCCTTATGA[G/T]GCAGAACAGGCTGGGT rs2051549 AGCTCTTGGGAATCTC[A/G]GAGACAGAGTTATCCA rsl015575 AGTTTTATTACTTACA[A/G]ATCAGTAGCAAGGGAC rsl413896 AAGGTCACCAAGTTGA[A/G]CATGTATATGGCACAG rslO485136 GATGATGCCTTTAACAIA/GIAGAGAGAGGATGAGAA rs2260393 TCTCACTCTTTCCTCC[A/G]CAAACAGAGGAGTCTC rsl578656 CTGAACATAGTCAAGAtC/T]GGCAATTCTCTCCAAA rs2146162 TAACTTCCTCTTTCAA[C/T]TTACCATGTAATTCCT rsl295135 AAGTAAATATGTTTAG [A/GJAGGAAAATCCGTACAA rsl2154706 AGAGTAAGTGACTTCCIA/TJATTGAAAAAGATAGCT rslO281917 GTCTTTATCCTCCAAA[G/T]GCCCTAATTTGGCCCC rs2110290 CCAAAATCAAAAGCAAIA/GJCATCCATTGTACAAGC rsl0487028 TGTCAGATCTGCGGAAμ/CJGATGAGTAGAATGGGT rs2538906 TCACAGGGCTAATAAC[A/G]GGAGCTTTGGCCAACA rsl0487029 GCTAAGGGCCTTCAAA[A/G]TTTCTATTGCTTTACA rsl7167808 TTAG I I I I I I CTAGCC[A/C]AGCAAAGTTCCTGAAC rs2350786 CATGGAGGCAAACTAC[A/G]GTAGCTGATTACCATT rslO9O38O9 ATAGCCCTAGTACAGC[A/G]AAAGAAGTGGATGGAG rs2614062 TTAAAGTTGTTAAGAAIC/ηAAGGGCTACTTTAAGA rsl6923447 TTTCTTGTTGCCAGGA[A/G]TATTTTCATTAACATC rs2046370 GGTTTAGGTTTTATAG [C/T] AG ATGCTTCCTATTTG rsl849692 GCAGACGGTTTTGAGC[A/G]GACCACGGAGTTTTGA rsl2779658 AATAAATCTACCCTAA[A/G]TGAGCCATTAAAAACA rs2251760 TCACTTGGACACTCAA[C/T]CTGAAGCAGAGAATCC rsl58688 ATCTAAAGAGTTTCCA[A/G]AGAAAGTATTAATTCA rsl58687 AGATCAAACATGAAGA[C/T]GAGGATTAGTTAAGAC

rsl6910240 GTCACTCCCTGTCCAA[A/G]TCAAACCTGGATTCTG rsll999319 AAAGCAGGAAGATTCC[A/G]GAAAGCTGGGCACCAT rs2488733 ACAGATTTAAATπTC[A/G]CAAAATACTCTTACAT rsl868996 AAACTTAGAAATTAAC[A/C]ATCTTGCACACTAGTA rsl010860 TTTCCCGTACTGTAGA[A/C]AACTCATCAGCTCAGA rsl0788380 GTCAGGATGGCTGGTG[A/G]CAACAATGGCCCAAAT rslO51O115 ATTTTAAACGGTAAGA[G/T]AATTTTCATACACACA rslll2587 ATCTCTAAGTATAAGC[A/G]CCTTATTGACAATCTC rs2078622 TAGGTCTAAAGGTAAA[A/G]TCCTTGTCTGCTATTT rsl033282 ATTGCAACATGGTATA[C/G]CTCATTATAAAGCAAT rsl736010 CCAGTGAACATACAAAfC/GlAAATGACTGGCATCCA rs200700 GTCTGTTGTATGGGGAIA/GJGAAAAATTGGGATTTG rs2248339 ATCCCAATACAGACrC[C/T]GACTAAGGCTTCCCTT rsl444268 CTTCTTACAAAGTGGC[C/T]AAGGGTTCTAAGAATA rs2252884 AGAAATGAGTTGCCCA[C/T]CTAACTAGGGTGATGT rslO14994 ACCTGTAAACAGACCT[C/G]AAAACATAGTGTTCAC rs2094881 CGGTTGTGAGGGTAAG [C/TJATACAATAATGCTAGT rs234787 TGCACCCCACCAGAAC[A/G]GCTTACAAACCAAGCG rsl7004748 AGAACAGGTATTACAA[C/T]TTCTAGTTACTAACAA rsl0901545 AAAAAAATAGCTAATAlC/ηGTTGAGGAGGAGGGAG rslll95125 AAAAAACATCAGAGGA[A/G]GTATGAGCATTGTTTC rs221153 AAAAAAGCCACAGGAGfC/GlAACCCTGACAGAGAAG rs2396328 AAAAACAGTCTTAAGAIA/GJGCGTAGTAAACAACAG rsl2631421 AAAACAAAAGGTCTCA[A/T]AAAGCTATCAAACAAT rsl2895787 AAAACTACTTTGAGAC[A/G]AATTTCTTAGGCCATC rs2203894 AAAACTTAGAGTTCTA[A/T]AGTGGACCCGACCCTT rsl821432 AAAATAATGTGGAAAAIA/GJGTGAGTGGTATGCCCA rslll4418 AAAATATATGAAAGCAIA/GJTACTAGAAAAAGTGAG rsll684348 AAAATATATTCAGAAC[A/T]ATTCAGAGGAAACCAC rsl2485415 AAAATATCTGCAGCCA[G/T]TCAAAATACTCTCGTG rs255574 AAAATATGTTGACTAA[C/T]CATAACTGAATACAGA rsl2505348 AAAATGAAAGTAGAACfC/TJGGATGTGGAAGAGGCA rslO968561 AAAATGGACACATAGA[C/T]TAGCAAACC I I I L I I C rsl6917845 AAAATTTGCTTCAGAAIG/TlAAGAGTAAAACTGTTG rsl340186 AAACACCAGTCCCTCA[A/G]TGACAAATTTTAGTTA rsl2461941 AAACATCCAGGATCCA[A/C]ATGGCTATTGGGAGTG rsl0989294 AAACTGTGGCTCCTTT[A/G]AAAGAATAGTTTCTGA rs2227127 AAAGACATGAAAGGAAIA/GITGTAGTTTGGTTTGAT rsl7410853 AAAGGGCCTGGGCTAA[G/T]TAATGTCAGTTCAGTT rslO12424 AAATAAGAGAAAAGTA[C/T]GGAAAGATGCTAGCCA rsl584308 AAATACATGAAATAGC[A/C]GAAGTCATTTGTTACT rslO61577 AAATGAAAACACACAA[A/G]TTGAAAATGCACAGAA rslO143885 AAATG AGGACCCTGAG[A/G] AATTG AGTGTTTACCC rsl356952 AACCCAGTCTCTTAAC[C/G]ACGACTCATTCTTCAC rsl2981961 AACCTTGGTCCTCTAA[C/T]TCTAGATCCACGGGCT rsl7435983 AACTGACTGGACTCAA[C/T]GAAATCATAAGCTTAG

rsl905581 AACTGCAGCTGCCTCA[C/T]AATAAAAGGACAGGAA rslO26453 AAG AATGCAG AGTAGG [C/T]AATTTGTGTTCTGTCC rslO3O656 AAGACACTCAGTTTCAIC/GIAGGCAGAAAACCTGGA rsl519635 AAG AG AAACTTTTG AG [A/GJCAATTTACTGAGCTAT rsl2622278 AAGAGACAAAGAGAGAfC/TjAAAGTAGTCAAATGAC rslll00741 AAGGAAATGCAGATGAIC/GJTATGGTAATGAATGAA rs2577302 AAGGGTAGAAGGAAGA[G/T]CATGATGGTACATTTT rslO57848 AAGGTGCTAGCCTCAT[C/G]AATAGGACAATTAAAA rsl655058 AAGTAAAATTTCCCAT[A/G]AGGTGCTGAAATCCAA rsl543265 AAGTAAGGATCTAAAA[C/T]TGGACTCTGCTGTACT rsl7022224 AAGTACTGAATGTAAAIC/GlTTCTCTATCAGCTATC rsl0081463 - AAGTGAACAAAAACAT[A/G]AGCCAAAGACAATGAC rsl0474222 AAGTTTCTTCAAAGGAtG/TJTAGGCATTTATAAGTT rsl924664 AATAAACAAATTAATA[C/T]CTTGAGCCTGTTACAG rs2013004 AATAAATGGTCTCTCA[C/T]GATATTACATCTCCCC rsl464412 AATAAGTGmTTTAC [A/G] CACCAATG G CTTCCTA rsll778828 AATAATCAGTTGAAAAIC/TIGAAAATGTAAGATATC rsll230180 AATAATTCCTCCCCAA[A/C]CTCTCTGTCTCTCTGA rsl7160205 AATAGCCCAAGTATAA[C/T]GGTAGCTGCTGTTTAT rsl368761 AATAI I I I I CTCTACC[C/G]GAATCCATCAGCTACC rsl7114146 AATCAGAAATTAGGTA[C/T]GAGGAAACCAAAGCTT rsl903262 AATGCTTTCATGGGCA[C/T]TATATTGTTTAGTCAT rsl68534 AATGTGTGAATCAGAA[AZG]TACAATCAAGAGGTCG rsl7171395 AATGTTGCCAATGCAA[C/T]CAAGAAAGCCTAGAGT rsl7649710 AATTAAAGTAACCACA[A/C]AATCCTGTAGCTGACA rsl0904908 AATTACTATGGCATAT[A/G]AAGTACTACAGCACGG rsl0921253 ACAAATGGTGCACAAA[C/T]AACTGGACTGCCACAT rsl487025 ACACAGCCTATATGCC[A/G]AATAAAACTAAACTAT rsl699002 ACAGACATCCAGTTCC[A/C]CCTCTTTGAAACAGCT rsl7334370 ACAGCTTCCATTTTAC[C/T]CATCATCCCCATTTTG rs2232847 ACAGCTTGGCTATGGT[A/T]ACCAGTCTTCAGAGGG rsl6988320 ACAGGAAGTGTTGACA[C/T]ATATTTGCAGAACTTC rsl380749 ACAGGCCCTGTGACAA[C/T]GTCTGGCTGACAAAAG rsl0920754 ACATAGCTAAAAATGAIG/TJATCAAGGACTAAATCC rsl2554104 ACATCAATGATTGACAtA/TJGGGTAAAAGAGAGAAA rsl7619153 ACATCACAGATGATGA[A/C]AGAAGTACTGTGTTCT rs2169288 TTATCAGGGAATGGGC[G/T]AACTTTATCCAACTGG rs2358766 ACATCCCCCAAAGCAA[A/G]GTATTAAAATGATTGT rsl7006048 ACATCTCACACTAACA[A/G]GCAAATTCAGATGCTG rsl2671550 ACATGAGAAGGGCTGA[C/G]ACACATAGATTTCTGT rsl0263381 ACATTAAACTCTTGGA[C/T]GTCAAAAATAAACACC rsl3111631 ACATTACTACCATTTC[A/T]CTCTTCATCGGGCCCA rslO159959 ACATTTTTAAAGTAGAIA/GITAACGCAATATTAATA rsl7025554 ACCCTGCAGGAGATTC[A/G]CTACAGCAGAAGGCAT rs204767 ACCCTGCATCTAATCA[A/G]GCCTCCAGGTCTAACT rsl7000687 ACCTTCAAATGGATAA[A/T]GGCCATAGGGAGCTTA

rsl7137871 ACCTTGAGAGTAGTGA[C/T]ATTCACATTAATATTA rs2090018 ACCTTTTGGCTATCGC[A/G]AATTATGCTGCTACGA rsl443360 ACGACAAGCAGGAGTAIC/TJTACAAGATGAAGGGAG rsl545741 ACACGTAATTTACTTC[C/T]AACTGTTATCCAAGGA rsl6889748 ACTAAAATATGATGAC[A/G]AATCTTCTTCAGCCAT rs2358785 ACTACTCAGCAACAAA[A/G]TAGAATGAGGTATTGA rsl0106681 ACTAGAGTGATGTTTC[C/T]AGAGGCCCAGGAACAT rs2590260 ACTATGGTATTAGAAA[C/T]GCTAACTACAGAGATG rsl390435 ACTATGTCATTTAAAA[C/G]TCACAGAACTCCTAGA rsl2188581 ACTCCAAGTGTGATTA[C/T]GGAAGAGTGACATGTA rsl7031476 ACTCGATTCTTTTCTC[A/C]ATTATTGCCAAATTTA rs2052815 ACTCTACTTTTTTGGG [A/C] AATCTTGTTCTCTACT rsl966590 ACTCTCAGTCACTCAA[A/G]CAATTGTGAAATGTGC rsl545904 ACTCTGAAATTTTGTA[A/C]CATTATGGCTAATGCA rsl7302379 ACTGACATTTTAGACA[A/G]AAGAGCAGAAATTCGG rsl3106297 ACTTCTGAGCTGGCCA[C/G]GGAGGAAAAAGATGTG rsl7026903 ACTTGG AACAAATCTG [A/C] ACTCACTTTGTG ATCT rsl2038994 ACTTGGCTTTCAACCT[A/T]ACTCCAGCTCTATAGT rsl0748424 ACTTGGTTGTCAGGTA[A/G]GTAAGCAAGAAATTCT rsl563734 ACTTTCTGCTTTTGGA[C/T]GTATAAGCACAGCGTG rsl7825393 AG AAAG AGG AACAGTG [A/G] AAAATG AAATTGGTAT rsl036515 AGAAAGTAGTCAGATA[C/T]GCTAAGTTCTCAGCCA rsl7492851 AGAAATAGAACTTGCA[G/T]AGTAAGCGAAAACAGT rsl7792496 AGAAGGCAAACTACAT[A/G]AAACAAGTTATmTG rslll87808 AGAATATAAGGGAAAA[A/G]TGGCTCCCAGATGCCT rs2370919 AGAA I I I L I IACCGAT[C/T]AGTCTCTGGCCTCTTT rs2158050 AGACCAGCACACAAAAIC/GJTATCACTAGAAAGTTA rsl3386098 AGACGCAGCCTAAGAC[A/G]AAAACTGCTTCACAGG rs2348914 AGACTATGAATTCCTA[C/T]ATCTGCCACCTGCAAG rsl453688 AGACTGGCAGGCAATA[A/G]GGACCCCAAAAATGGT rs2335808 AGACTGTAACTCAAAGIA/T] AGCTTGTGG ACAG AGT rsll848645 AGAGAAAATTAAAACA[G/T]TGTTGGCCAAGAATGC rsl303621 AGAGAAGCTAAGCTTG[A/G]AAACTCAGTCATGCAA rsl437728 AGAGACTATGCCTGGC[A/G]CCTGGTCAGACAGTGT rslll41918 AGAGAGCTGGAAAATA[A/C]CATGGTTCTTTCTCCT rsll044750 AGAGAGTCCCTACTAA[C/T]GAGAAAGCCCTCACCA rsl0754555 AGAGCCATTGCAGCAA[C/G]TGGTTTCTGACCTCCC rs2363246 AGAGGAATTGCATGAC[A/G]AGGCTTCTGAGCAGGA rsl920584 CATA I I I I I I GAATAA[G/T]GATATGTCCAGTGGTT rsl241940 AGATACACCTAGAAAC[AZC]CATATACTAGCTGTCC rsl0803196 AG ATATTG AACACCAC[G/T]GATTTTAAAACACAAG rsll010400 AGATGGTTATATGACC[C/T]CAATTGCAAAGATGAT rsl726392 TCATTG CTTAG CTTAG [A/G] ATTTG ACTG AAG AG AC rs2638952 AGCAACAGACTAGGAA[C/T]GCTGTCAAAAAAAACT rsl350775 AGCAGAGAAATGGACA[C/T]GCATGGTGAATCTGGC rsl2143838 AGCAGCCAGAGGTCTA[A/G]ATGTCATTTGTTCATT

rsl75851 AGCATACACTTTTCTA[G/T]GCCGTTTTACAAGGTG rsll008612 AGCATCACACCATTCA[A/G]GGTGAAAGCACTCGCA rs210664 AGCATCCTGAATG ACA[C/G] AG ATAAGG ACCATATT rsl0081428 AGCATGTAACGCTGGA[C/T]GGATGTAATGCCTAGA rsl969793 AGCATTGCCTGCATGA[C/T]AGTAACAGTATCAACT rsl3041126 AGCCCAAAAGACTGGC[A/G]GACACTCAGAAAAGCC rsl333147 AGCCCATG AGGCAAAA[C/T]TGATGTCTCACCTTAC rs2317704 AGCCCGCAAATGACAC[C/G]AGCTAAGCATTGTGCG rs2270459 AGCCTACTTCCAATGA[A/C]CGTGAGATCTGAAAGA rsl418720 AGCTACAGTGACTTGG[A/G]ACAAACACAGCTGAGA rsl6989635 AGCTGTCAAAGTCCAA[A/C]GCAGTGTCTAGGCATG rsl489890 AGCTTCATTAACTGAC[A/G]GGACAGCAGAAAAGGC rs2331964 AGCTTGTCAGACTAGA[C/T]GAAAAAGCAAGACCTG rsl7588248 AGGAAGTGGCAACTCA[C/G]CTGGGATCTAAAGAAT rsl009253 AGGAATGGTGAGTAAA[A/G]CTGCTGCCCTTAGCAA rsl342810 AGGACTGAATGATATA[C/G]CATCCCGAAATATGCT rsl418444 AGGAGGAGATATAAGAIC/GJGTGATACCAGGAGAGT rsl647965 AGGCATTTTAAGGAAA[C/T]CGATCTTGGTGTGTTC rsl68965 AGGCCTCACAATTAAA[A/G]CTGACTACAAAAAGAA rsl94781 AGGCGCAATGATTTTA[C/T]GGTAGAGGTGCTTTTG rsl556640 AGGCTATCTGAAAATC[C/T]AGAGTTCATAGATGCC rsl6955364 AGGCTCCAGCTTTTCC[A/G]CTACGTCTGCTGAGGC rsl0071774 AGGGCCTTATGTGTTA[C/T]GTTAAGCACCAGGAAC rsll868002 AGGGGAGACAAATACA[A/G]CTGCTTGACCAGGTTC rs256772 AGGGGTTCCATGAGTG[A/T]ATACCTTTGTCAAAAT rs2423258 AGGGTGCACAGTTTAA[C/T]TGTTCTTGGATGAAAG rsl385662 AG GTCTTG CCTG GTCC [A/G] C AGTCTCTTC AACTTT rsl550617 AGGTGGACCTTCAGAC[A/G]ATCTTAAAGTGTCAGT rsl0072570 AGTAAAGAGTGGTTGAtC/TjAGTGGAGCTCAGAAGG rsl215658 AGTAAAGTG AAAAACA[A/G]CCGTACCTGGAATACT rsl891490 AGTAATCACTCACTCA[A/G]GTTCCTTAATCACATC rsl345683 AGTATG ACAGG ATCAG [A/T]CCAGGAGGCTTGCATG rsl0991736 AGTATGGACATAGGAAfA/GlAGATGCAAGCAAACTG rsl56168 AGTCATTCAAGGTCTC[G/T]CTTCAGCTTGCCTCTC rs2426299 AGTCTAAAAGAGGCCA[C/T]TCCAATAACCAAGGAT rs243839 AGTCTGAGTTTAATCA[C/T]CCTGCAATACTGTCCT rsl243446 AGTGAAACACACATAA[A/G]TGAGCCATGCAGAGAG rsl602 AGTGAGACATGGATGA[C/T]ACCCACACTTCACTCT rslO114374 AGTGAGAGAACATGTA[G/T]AAGGCAGGCCTGGCAC rsl3273013 AGTGATAGAAATAACA[C/T]TGTATCTGGGTTCATT rsl337966 AGAGTTCTGCTACTAAIA/TlATATGTTAGAATTGTG rsl0051407 AGTTCTAAAAATCATAIA/CJGGCAGAAATTGAAAAA rsl7358302 AGTTTGCAAGAAATGC[A/G]CAAAGTAACTGTAAAT rsl0105587 ATAAACAAGCTGTTCC[A/G]ACTTTTGAACAAATCC rsl2585923 ATAAACTGGCAGTTCA[C/T]AGAAAGGTATCTTCAT rs2296734 ATAAATGTGTGACATAIC/GJTAATTTACAGGAGATT

rsll595123 ATAAATTTAAGAGAGC[A/G]CGGCAGGTTTTGGAAT rsl361196 ATAACCTAGATAG ATG [A/G] AAAACCATTATTTCTG rsl731901 ATAATATTCTTGCTTT[A/T]AAAATGTAGCTCTGGC rsll23024 ATAGATGCAGAATGGA[CZT]TAGGTGTGCGATAAAT rs2282775 ATAGGTTTGTGTTTTAIC/TICCTTGATCAATTTTGA rsl2452883 ATATACTGTAGACTTA[C/T]AATAAAATGAGCTAGA rsl6870107 ATATCAAAAAGTTGAA[CZT]GTCCCAATGGACAATT rsll596873 ATATTCAAAAAAGGTC[AZG]AmGGCTTTCCATTT rs2585512 ATCAAAAGAAGGCAAA[A/G]TACTCTCATTTTTGTG rsl0077522 ATCAGGTCATCTGGAC[A/G]AATCTTGAAACACATT rsl356791 ATCATGGCCAATTTCA[CZT]GCTACTAACCTGATGC rsl896890 ATCCAGTACATGATCC[AZG]CCGTGACAATGAGTAG rslO471462 ATCCCTGCAAGACCAT[CZT]AATGTAATGAACAGAA rsl0205352 ATCCTGTGGAACCAAT[CZG]ATAAGTAAGAAAGAAA rs2140525 ATCTCAGTGGTTATTA[AZG]GTTGCCAGACACATGG rsll35750 ATCTGTGTGTGGCTAA[CZG]GATGAGGATACAGAGA rs2031817 TGAAATTTATTCTGCA[CZG]GAAATGGGCAAACCAA rsl7634562 ATCTTTGAAACTTTAC[AZG]AGGAATGCCACAGGTC rsl2472418 ATGACGTGAGAAGAAA[CZT]AGAAACACAGAGAAAT rsl2207570 ATGATAACAACGATGA[AZC]GTATTTCCAAGTTCGG rsl011275 ATGATCAATCCTTTAA[AZC]AACCAAGTATGTATTA rsl3254344 ATGCCAGGGCTGGGTA[CZT]GCATAGTCCATGTTGC rsl6900399 ATGGAAGATGGTTAAA[CZT]GGGGAAAATTGCATTC rsl0083735 ATGGGTATATTGCATA[CZT]GAGTAGGGATTTGGCT rsl0754026 ATGGTAACTATGCAGA[CZG]ATTTCCAAGCAATTGA rs2324872 ATGCAAATGGATCCAA[CZT]ACTTGGTTAGCCAATA rsl2693436 ATGTCATGAGAAAATC[AZG]AATCTAGTGAACATTT rsl546060 ATGTGGGGAGATGGAT[GZT]AATATTGGGACTAGTT rsl2455599 ATGTTAATTTGTTTGA[AZG]TATTGTGCACAATGTC rsl7682873 ATGTTGAAACACTTAA[CZT]CAAATGCTTAATGCCT rsl265169 ATTAAAATGACTTTGA[CZG]CATACAACAGGAGCAG rsl3153675 ATTAACAGGGAGAAAA[CZG]TTGCATTAAGAATAGG rsl7492893 ATTAATCCCTTCCAAA[AZG]TTTGCAAAACCACTAA rsl6843947 ATTAGATTGTTTCACC[AZG]CGGCCTCGATGTAAAA rsll949052 ATTAGCTACAAGTGGA[CZT]AGTAAAGCAGGGAACT rslll56316 ATTAGTGGGTATGTGG[AZT]AGAATTGAGTTATCTG rsl7081619 ATTATCTCCTGAAGGA[CZT]GATTTAGCAAATTGAT rs2350516 ATTATGAATTCAATGC[AZG]AACAACCCTTCTCTGT rsl932604 ATTATTTGCCCAGACA[AZC]TGATTATACAGATGAA rs2528632 ATTCACTGAAGTGTGA[CZT]GGCGGGGAGTGGAGCT rsl2427691 ATTCATATCTCCATTA[CZT]CATCATGTAATAATAG rsl0879957 ATTGATTCCAGCCTTA[CZT]GAGGGACTCTATCTCA rsl812582 CAAACATCTGTAACAA[AZG]TGCTACAATCAAACAT rsl0136336 CAAAGGTTTTCCGCTC[CZT]ATGTTGTGGAATGCAG rsl0463573 CAAGACAAGTCAACAA[AZG]CAATAGTGCTGGAATC rsll873700 CAATATGTGCTGTCAT[AZG]AAAAGATCTTGAAGAC

rslO964178 CAATGCCAGAGTGAAC[A/G]ACCTCTAATGTTCTCT rsl0755926 CAATTAAATTGTTACA[A/G]TCACTTCACTGGGCCA rsl94782 CACACATGTATAGACAIC/GJACATACAACCTTCCCA rsl0508010 TCGATGGCATTTTAGC[G/T]CCTCTGTTATTGTCTA rs2408467 CACATGACCCGCTAAC[A/G]ATTCTTCTATCTTTTA rsl6989682 CACATTGATTATAGCA[A/G]TATTTCACGAAAAATC rsl553009 CACCAACTCTAGTTCA[C/T]ACCTCATTGTTGCTGC rsl7006815 CACTCTGGAAAGTAGC[A/C]AATTTGTTTGGAAAAC rs2473092 CACTTGTGAGACTCCA[C/T]TCTGTAACTCAAGGCA rsl923083 CAGCAAACATTTTTGA[A/C]CACTTATTACGTGCCA rs243849 CAGCCAACTACGATGA[C/T]GACCGCAAGTGGGGCT rs2110598 CAGCTTGGTATTGGGA[A/G]GCTCTTCTGACTCTCA rsll072153 CAGGAAATGCAGGACC[A/G]AAAGCACTCAAGCCTG rsllO22119 CAGTGACACCTATGTG[A/G]AGTGCTAATTGGGGAA rsll24769 CAGTGCTAAGAGGAAT[A/G]AACACTCATTGTGCAG rsl404868 CAGTTCTGGAATAGAG[A/C]ATATTGATTTATGACA rsll247842 CATAAACAACTTCATA[G/T]AACATCAACAGCAGAC rsll754490 CATAAATACTTGTGCA[A/G]TACCCTCAGGACCTGT rsll47138 CATACTAG I I I L I I CC [C/T] CTCCTTTC ATG ACTCA rsl278886 CATACTCTAATGGCAG[A/C]ACCGCAGCTG AAACAT rs2282036 TGAGCTGAGCTCTAGA[A/G]GGATGGCTTTTCATCT rsllO44739 CATCATTTCTATCCTG[A/T]AGAAGCCTGACACTGA rsll207744 CATCTAACACCTGCCTIC/TJAACTAAGTAGGAGGAA rsl7095265 TTTTGGAACAGCAGCG[A/G]AGACATTCTGCAGTGA rsl7019785 CATGACTTGAAGAACA[A/G]CGATAACCAAGCAAAG rsl7023520 CATGAGAATTCAATAA[A/T]CTGAGTTATGCCAGTG rsl2100200 CATGTGCAAAACTATA[C/T]CAAGTGAGTCCATATT rs2053859 CATGTTTCTGTATTAAfC/TlGTGAAGGTTATGAGAT rs2012296 CATTAGTTCACTTATA[A/G]CAATGGCCTCTAGCTC rsllll9385 CATTGCTTCTGAGTAA[A/G]TCTGACAACTTTGATT rsl332847 CCAAACTCGGTCCTTC[A/G]CTTGAAGATTTTGCAG rs2484664 CCACAAGTACTATTCC[A/G]AAAGAGTCTGAACCAA rsll033790 CCACACAGTGAGTAAA[C/T]GGCAAAATTCAGGGCT rs2585590 CCACCCTTCAAAGTTC[A/G]AAAACACAAATGAGTG rsl2594942 CCACCCTTCATCGGTCIA/TICTGGCCCATCGTTTTA rslll82904 CCACTATGAAGAGTCT[A/C]AAAGCTCCTAAAGACT rs2191201 CCAGTCCAGATCCCAA[A/G]CTCTTATCTAAGAGAA rsl0872807 CCATCAGACGCTTACC[C/T]AATAGTTGTGGCATCT rsl520653 CCATCAGTG GATAATG [A/G] AAATACG GTGTCTGTA rs2163634 CCCACACACTTCAAGA[A/G]TAGGCAGCACTGATCC rsl7491531 CCCACCATTCAGGGTA[A/G]AAGTTTCCACGCCATC rsl7091519 CCCAGAAAGCGAAGTA[C/T]AAAACCTATTCCAGGA rs2554621 CCCAGAATATTGTTGG[A/C]AGTCAATTAGGAAAGC rsll215072 CCCATTAAATGTGATA[C/T]TAGCTCTAGG I I I I I I rsl894524 CCCCCGCTACTGTGCA[A/G]CCGCCGTGACGACAGG rsll060924 CCCCCTGGATGTGCAA[G/T]TTATCTGTACAGCAAA

rsll237675 CCCCTGGCATAGTAGT[C/T]AAAGGCTGTAGGAGCC rsl368378 CCGCCATTTTAGTCAA[CZT]GGTCACTCTGTGTACT rs2237143 CCTCAAAGGGTCGGAC[AZG]AGAATATCTTCTGACT rsl7662568 CCTCCACTAAATATGA[A/G]CAGCCATTGTGCACAT rslO77939O CCTCTCTCCTACCTTA[C/T]GTTTAATTACTCAGCA rsll649061 CCTGATTTGATTACTA[C/T]GCATTTTAGATGTGTA rsl0941073 CCTGCCCATAATAAAC[AZC]CATCCAGAAGAGACCC rs2031280 CCTGTATG ATCTG ACA[C/T]G AACAG ATAGCCACAA rsll850870 CCTTCTATATTACAGG [A/C] ATTATCCATG CAATAT rs2154294 CCTTTTATAACATCAA[A/G]TATGGTCCAGAATTCA rs2562181 CGCTAAACCTGACAGA[AZG]CTCTCAGTGCGGTCTT rsl7792222 CGCTGCCTTTAATCCA[G/T]CAAAAAGCTTTTACCT rs2064947 CGGAGTGCTATTCTAA[C/T]GAGTGCTCCTCCAAGT rsl215664 CGGGATTCTGAAGTAA[C/T]CAGCGGCACTGCAAGC rs246277 CGGTCACAGTTAACTT[A/T]AAGAGCATACTGAATA rsl0765796 CGTTCATAAATTTCAC[C/T]AAGTCATCAACACAAA rsl7251278 CTAAAGACAGAAGGGC[A/G]ATCTCAAGATACCGAT rsl2346176 CTAAGAAATTTATTCC[CZT]CAATTAGGCAGCATTT rs2528398 CTAAGCATCAAAGCAG [C/T] ATCATACACGTTGCTT rs2423257 CTAATGCTAAACAAGA[A/T]GACTTCAATACTGGGA rs2334063 CTAATGGAGATATACA[AZG]TAAGACGAATGTTGTT rsl6966238 CTACTGGGCCTAGCAC[A/T]CTGTTTGGCAACAAAT rsl011300 CTACTTACTAAAGTCA[C/T]GCAAGGTCATTGTAAG rsll019030 CTAGGAATCACATAGAIC/GIAGAAAAAAGTCAAAAC rsll688740 CTAGGCTTGAATGAGA[A/G]AATAACGATACCTTTC rsl2539689 CTAGTGCATCATTGAAIC/GIGAAAGGAATTTCACAC rsl0263522 CTATCTTTTGTTGTAC[AZG]CAGTTTGCATCACAAA rsl7603170 CTCACCAGAATTTCCA[CZT]GTCATTTAACAACTCG rsl2431160 CTCAGGTTTTCACCAA[CZT]AGAAGTGGAATTAACA rslO14534 CTCCATCACTGGGTGC[AZG]ACACTCCTTACAGAGC rs2190963 CTCTACATG ACTCTTG [AZCJAACTTGATTTACTCCT rsl0104127 CTCTATTTACCATTTC[AZC]ATGAATGTTGTACCTT rs2426990 CTCTGAGCTTGTGGTC[CZT]ATATATTAAAAGGCAC rsl6905587 CTCTTATCAGTGGCTA[CZT]AATGACTATGAGAAAA rsl7567906 CTGAAGGAAATGGACC[AZG]CCCTGGATGCCTACAC rslll34649 CTGAGCTTGCCTTGCA[AZG]AACTCATGAAGGGTGC rsl526939 CTGAGGCTGCCCTCAA[AZG]TGATTCAGCAGGGTAG rsl0897992 CTGATATCTGCTCCAC[AZG]GACGTGTAAAATCACA rs2278791 CTGCCAGCTTTTGCAA[CZT]TGGAGGGAAAGGTGTC rsl3219256 CTGCCCCGGAAGTTCA[AZG]TAGAATAAAGATATCA rsl386736 CTGCTTGGTTTGACAA[CZG]TTAATATGACATTCAT rsl2306495 CTGCTTGTGAGCACAA[CZT]CATAGTGGTGAATGCC rsl6962997 CTGGAAGCATGGTCAC[AZG]AGCTC I ICI ICCTTCT rsl6849578 CTGGACAGCATTCCAA[AZG]AAGACCATGTGTTCTC rsl518758 CTGGCCAACCTGCTAA[AZG]TATATCCAGAATAAGA rsll951359 CTGTAAACTTCTATAC[GZT]ACTTTGTACCACCCAT

rsl3382085 CTGTACACCATAAATA[CZT]GTATL I I I L I I GTTTT rsl6882270 CTGTCATCCCATCCAC[A/G]AGATTCACTCATAGAT rs2286412 CTGTGATAGTTTATGA[CZT]GGAGTTGTTAGGGTCG rsll846532 GGACTTTTATCAGGAA[A/G]CAATAAATGCATTTCA rs2091113 CTGTTTAGCATACACC[A/G]ATTCCATCTGAGAATA rsll243840 CTGTTTCAGAGGTTCG[A/G]ATGGAGCGCCGGGGCT rsl7823223 CTGTTTTCTAGAGCAA[C/T]GACATAGGGCAGTGGA rsl0801047 CTTAAAmAAATTTA[AZT]CTCTGCTGTGTATTTT rsl387859 CTTCCCTAAGCCAAAA[C/G]TGTCTGAGAACATTTT rsl0736004 CTTCTTTTTACCTATC[G/T]CCACTAGTGTCACTGA rslll51820 CTTGAAATTTCCTCTA[G/T]GATAGCTTCTCTTTGG rsl6948981 CTTGAACTGAGTAGGC[C/T]AAAAATTTGCTTTCCT rsl7032728 CTTGCTTTTAACCCAA[C/T]TTCTTAATTCAGAACA rslO189426 CTTGGATATGGCCCAA[C/T]CACAGAAGTAAATTGT rsl7104962 CrTGTTTTTAAATCCT[A/G]AAGTCATGTCAGTTTT rsl7653276 CTTTAGAAAACAGAGA[C/T]GGTGTGCTTCCAGCAC rs2252550 CTTTAGAACATGAGCGtA/ηAAATGGATAGAAGTAG rsl359437 CTTTATGACATCTCAC[AZT]CTGGTCCAGACCAAGA rslO281O59 CTTTCCTCAGGTTAAA[CZG]AAGAAATCAGTTCTGA rs2647442 CTTTCCTCTGTCTTCC[CZT]CATTTCTGCTACTGGG rsl7127881 CTTTGACAATAATGAG[AZG]CGAGTAGATGAGGACA rsl507214 CTTTTCACTATCATCA[CZT]GAAATTCCTrTGCTTC rsll045190 CTTTTGCACCCAAGCA[CZG]TAGAACTAAGTGGGAT rslO894319 CTTTTGGAATTGGAAC[CZT]CATATCAGTTATCTTA rs2590577 GAAACATTACCATATT[CZG]AAGACAGTGAACAAGT rsl2595526 GAAACCTGCAGTGAAA[AZG]CGTAAGGTGATGGAGC rsl7562778 GAAAGATATAACCAAA[AZG]CCTL I I I L I I CTCCAC rsll845632 GAAATGCAGTTTGATA[CZT]GAGACACTGAATTGGG rslll63592 GAACTTCAAAATTCCA[AZG]GGTGCAAATATATTGT rsl0882052 GAATAAAGCCTAGTAA[AZG]CATGGCACGCTAGTGA rsl746595 GAATACATATAACCAA[CZT]AGACTCATATCCAGAA rsl3253981 GACACATTTGCTAAAA[CZT]TATACAATCACAGCAA rslO952491 GACATCAAAATTATCA[AZG]TAACGCAAAATATAAG rsl876853 GACGAGGCAGGAGCTC[AZG]ATCAATGCTGGAACAT rslO8O7222 GACTCACTATTCTATC[AZG]CATTGGTCAATTTGTC rsl879511 GACTCCTCATCAGATG [AZG]AACAAGTGTCTCTCGT rslO881893 GACTTCAATCGGCAAA[AZG]ATGTAGGGACCAGCCT rsl487837 GACTTGATCTAACATA[CZG]CATTTATCACGGTGAA rsl7187821 GACTTTGAACATTTTC[GZT]AATCAAGCAATTATGG rsl6852503 GAGAAAAGCCAAAGAA[AZG]TAAATCTGAGTTACCT rsl2142584 GAGAACCAGGGAGCCA[AZG]TCGAAGGGTAGGAGAA rsl0777487 GAGAGAGTTAGAGAGA[CZT]AGGTCAAGTCCTTAGT rsll230188 GAGATGTAAGGACTTC[CZT]AGGATTTAGTATGAGT rsl0898674 GAGCACCTTTTAATGC[AZG]CTTATCTGCCATCCAC rsl2504135 GAGCAGGAAACATAAA[AZT]GGATGAGCAGGCTGCT rs2646261 GAGCAGTCTTTAAACA[CZT]GGGCAGTGCACGCACA

rsl0116332 GAGCTGCAGAGGACAG[A/G]ACGTGACCCTACCACC rsl6973718 GAGGCTCTGCATCCAG[G/T]AATCCAGGCTTCTAGT rsl7428570 GAGTAATCGCCCAAAA[C/T]AGTGTTTGCCAAAATG rsl0795064 GAGTCAGGCTGGTCAA[C/T]TTCAAAATACTTTAGA rs2002497 GAGTCTTATCTCCCCA[C/T]TCCGAATACAAGCTCC rsl6908507 GAGTGATGTGGATGAA[A/T]CTTTACTCCATACAAT rsl7029013 GATAGCATTAAAGCAA[C/T]GGTCCCCTTAATTTCC rsl2055256 GATCATGCCATTCTTA[C/T]GCTTAAAACCCTTCAG rsl0998910 GATGAAAGAGGCACCA[C/T]TGGAATTTACAGCCCA rsll931702 GATGCTGCTATGACCA[C/T]TCACTTACAAGTTTTG rsl7641512 GATGGAGAAAAGGTCAIA/GJGGAACCGGCAAAGAGG rsl0016434 GATGTATATTATCTCA[A/G]AGACTTACTAGTTTAG rsll633570 GGAAAAGGCAGGGTTAtC/TlAGCTGATGAGTTTGAT rsl933701 GATTTTATTCTAAGCA[C/T]GATGGGAAACCACTGG rsl2454952 GATTTTCTGCCAAGAC[A/G]ATAAGAAGAGTACTTT rs2070950 GCAAAAAAAGGTAACT[C/G]AGGACTTAGTGAAGTG rsl472095 GCAATTCGTAAATAAA^/GJCAAGTGAAAATGGAGA rsl0419078 GCACAG AGTAGGCCAG[A/G] ACCG ATGGTG ATACCA rsl6948985 GCACCCTCTGAAATAA[C/T]TCTGCAAACCACTGGG rsll707973 GCACCTCCTCTGTCCA[A/G]GATATGATGCCAAGTA rsl7095295 GCACTGTAGTCCAATA[C/T]TAATTGTCACTATTAA rsl541749 GCAGCTTTGTGCACTC[A/G]CTGTCTTTGCAAAGTG rs2224249 GCAGG ACTCACTGCAG[A/G] AAATGG AAAAGGTGCC rsllO3797O GCAGGGAGACTTGTCA[A/G]GGAAGGGCATCCGAGG rsl7117193 GCATAGATAGATGGTAfA/GlCTATGGAAACAATATG rsl7080594 GCATGGCCTTGGGGTA[A/T]TACACTATGCCTAAAG rsl2403846 GCATGTTTCTAAAAAC[A/G]CTTCAGGAATCCAGAG rslO9O1198 GCCAACTTGCTTGAGT[A/G]ACACTGATGAAAAAAG rsl2245743 GCCAGACCAATGTTGA[C/T]CTTTAAATTACCCCAG rs2502845 GCCAGGAAGAGTTAGqA/GJAGTAGAATACTATAAT rsl7566763 GCCTAGTGCAAGGAGG[A/G]ATGCTATTCAAAAATA rsl0736593 GCCTCTTTCAAAACTA[C/G]CTTTCTATGAAGTGAA rs2070951 GCCTTTGGTCTCCATC[C/G]CTAACAAATAAATTTA rs2171304 GCGTTAG AATTAG AG A[C/G]G AGCCTGTG ACGCTTG rsl7258731 GCTATCGATATTTCCA[A/G]GGGGATTTCATTTATT rsl3375160 GCTATCTTTCCATGAC[C/T]GAAATACTCATGCCTG rs2069112 GCTCCCTACAGTCTCC[A/G]GCATCAGTCTGTTCTC rsl694594 GCTCTCCAATCCTCTA[A/G]CTTAGTCTGCCTGTTG rs2025445 GCTCTTATTTGCTCTA[C/T]AATGCATACAGGTATA rsl0120212 GCTGTGTTAGTTTAGA[C/T]ACTGCCTAAGTAGGTT rsll663602 GCTTCCTTATTAGATC[G/T]CATTGCCTCTCCCGGG rsl359150 GCTTCTCATGCTCCTA[C/G]CTATGGCCTTCCTATC rsl0737615 GCTTCTGCATATTAAT[C/T]AGTTGAGCATTTACAG rsl66412 GCTTTAAACCATGACC[A/C]AAATTTAAGGTCTAGA rsl2533988 GGAAAACTCAGGGGAG[G/T]AAACAGCTTTGAAGAT rsl0168390 GGAAAGGGACTGCATA[C/T]GGCTTCATAGGTTGGG

rsl537340 GGAAGAAGAGTGATGA[CZT]GTTATGAAGTAAACAA rsl7256169 GGAAGGGAGGTAATAC[AZG]GATCAATTACAGATGT rsll780672 GGAATTTAGCTAAGGA[A/C]ACATATGAACCTCTGA rsllO16947 GGACTTTTGAAACAGA[A/C]AACAAGGCTGAATCTC rsl0859340 GGAGAGCACTCAGGTA[AZG]CAACACAATAGATCTG rsl2472311 GGAGGTGAGCTCACCC[AZG]AGATAAACGGCTGGAC rslO514926 TATAGATTACAAGAGA[AZG]AGGCTGACTACAAAGT rs2455974 TCACCATAGAATTATA[C/G]AAGTCAGATTTTCTGC rsl035704 GAAAGCTTTATCTACC[G/T]GGAACATTAGCATTTC rsll246628 GGATTTATCCTACAAA[C/G]GCATATAAATGGGAAA rsl7801910 GTAGATTGAGGGAAAC[A/G]CGAATATTTTAGACCA rsll027609 GTCTATTTTCATACTA[A/G]CACCGTGCTGTTTTGG rsll752725 GTTGTCTTAGAAGCCA[CZT]GGGAAGCAAACGTATG rs2503293 TAACCAAAGAGAGCTA[A/C]AAAATTAATGAAATTC rsl7094449 TACTTTTACCTAAACA[A/G]TAAACATTAGCTATGA rs2194251 TAGATATCTCGCTCTC[C/T]ACTTAAGGAAAGAACA rsl0235865 TATCATAGCACTTATA[C/G]AGTGTTGTGCCATTGT rsl7659181 TATTTAAAAATCAACC[C/G]ATAAGTCTTTCACATC rslO172617 TCAAGAAACAGCCAAA[C/G]AGTGTACCTGCAGTGG rsl7680943 TCACTCACTCTCCACA[C/T] ATAACTG GTAAATG GT rsl7818395 AGAAGCTGAGCTCTAC[CZG]GCGGGATAAGATCAGC rs2182867 TCCTAAAAGTTCCAGAlA/GlAAACTGTTGCTCTTGA rsl471484 TCTTATTATGACATTC[CZT]CACAAAAACTGCAAGG rsl450827 TGAATCCTGGTCCTTC[A/C]ATCTGGCGTCATTTTA rslO934261 TGCTGGATTTGAAGAG[AZG]AAATGAGAACCAGGAA rs224630 TGGCAATCACAGAAGA[AZG]TCCTTCTCAGACTGGT rsl3319491 TGGGAATTACCAGACA[AZC]CTTTGGGTATGTTCTC

γS1873230 TGGGAGCAAAACTCCC[CZT]GATACATTCTAAATAT rsl6880153 TGTCTCTCTAAGCCAC[GZT]AGAACTCCCACTAAGA rsl003081 TTAATTCTGACCATTC[AZG]CCCTTGTTCTTCGTAC rsll019014 TTACAAGTGGTACTGT[AZT]AAAACAAGTGCAGCAA rsl2693546 TTACCTGTGGTGTAGC[AZG]ATTAATAGCAAGGAAT rslO5O3O76 CTCTTCTATCTCCTAA[CZG]TATTGACAGAGAACTT rsl0898675 TTATAGCGATACACCA[CZT]AATAAATATGTAGCTA rs2316305 TTCTACAATCAAAATC[AZG]GACAGGTAAATAGATT rsl653157 CAGGCAAATGTCCAAA[CZT]GAGCATTAGGTGTACG rsl464435 TTGCAGTGACTATCAA[CZT]GTGAGTCCAAATTCCC rsll917361 TTGTTGGTGACATTGA[GZT]ATGGTCGAGCTAGTCT rslO184559 TTTTAGGACATTTTCA[CZT]CAACTCAAAAATAAAC rs2055392 TTTTCTGTAGCAAGCA[AZC]CTGATCGTTCAGTAAA rsl509379 ACTTGCTGTTCTTGAA[AZC]ACCTCAAACTGTGTAT rsl0490076 AAGGGTGTGTAATAGA[AZC]TCCTACTCCAACAGGA rslO497221 TGGGTTTTACAGATAG[AZG]AAAATTTAGGTACATA rsl0485801 TTGGATGAAAACATTA[CZG]ACTCTATGGATGAGGG rsl0482872 TAAATTATAAAGCAAA[CZG]TTATAGCCAATTCTCA rsl0510647 AATTTTCCTACAGACC[AZG]ATCAGGAAGGACTCCA

rslO517287 CAGAGCAAAAGCATAT[G/T]ATAGCAAAGCATATAG rsl026975 AGATGCGTTTGCTCTA[G/T]GATGATCCTGAGATGG rsl421883 TACTGAGCTTAGAATG[C/T]AGATCACTCCAATCAT rsl0519913 ATTATTTTTATGTCAC[A/G]GAAGCCAATTTCTATT rsl99031 TTATTCCCTTATTCCA[C/G]TAATGCAAGGCTTAAT rsl6896055 CAGTTTAAAAG ATGTG [C/T] ATTTG AAC ATTTCTAT rsl0499782 GCAGAGCCTCACAGGA[C/T]GTAAAGATCAGAGAAA rsl7590021 GGTAATATGTGTGAAA[C/T]TGAGCCCTGCATTTTA rsl0504444 AGGTTTTCAACACCTC[A/G]CGCCTCAGTGCCTGTG rsl0504841 GATATGAGAAGAGATC[A/G]ACTCATTTACATCTTG rsl0509870 AATAACTCTCAAAAAA[C/T]ATGGTTTCTCTCTTTC rsl0501407 CCCAAAGCAAAGCAAA[C/T]GTAGGACATGAGAGTC rs221193 CTTATCCCTGGGGAAA[G/T]GACAGCGATTAGTACT rs2186664 TACCTACACTATGCCA[C/T]CTCTTTCCTATTTGTG rsl939046 AAAG CAGACATTG CCA [A/G] CTG GTTATCTCTTTTC rsl985220 CATTTTGAGAACCACT[A/G]AAGTAAAACTCATCTA rs2248225 TCGGTATGTGAGCAAA[CZT]GTTAAATGACATAGTG rsl332297 AAAACAACAATAAAAA[A/C]CTCTTCAAATCCTAAT rsl7056214 AAAATAAAAGGAATCA[AZG]ATTTATCCAGTAGGAT rsl7506977 AAAGAGGAGTACTCAA[AZG]GTTGTATATGTGTAAC rsl3105340 AACTAGGAAACCATCA[AZG]TATGTGACAAAATACA rsl6880395 AACTCTGGTGTTGACC[C/T]AGCGGGTAGCATGAGA rsl2526453 AAGACCTAGCCCCAAA[C/G]AGTTTATAGTCTAGAG rsl872829 ACGATCAGGTTACAAA[C/T]GCAATACATTAGGGAC rsl549876 AAGGTCCTGTCTGGCC[C/T]AGAGTATCTATTATGC rsl516093 AAGGTTAAGATGCTCA[AZG]TGAATAATAAATGGTC rs2193662 AAGCTGAGATCTTTGA[A/C]AAAAGGTTACAGGAAC rsl885574 ACCTTTTCTAACATCA[AZT]GTGTCATTGACACCTT rs2105450 ACTCTGGAATACCAAA[AZC]TACAGTCATGGCAGTC rsl0492276 CTTAAAGGTTATTACA[C/G]TCAGCTTCAAAATGAT rsl482047 AGAAACCATACAGAGA[C/T]TCCAGATGTTTGAATT rsll867831 AGAGCTAAAAACAGAA[C/T]CATTCGACCCAACAAT rs2309396 AGAGCTTCGATTTAAT[A/G]AGAACAAACATGATAT rsl7680905 AGATACAAACCAGATT[C/G]AAAGGATCTTTAATAT rsl2579380 AGCCATGATATGACAC[AZG]GGTTACAATAGATTAA rsl220573 TCTGAGGATATCTGCT[CZT]ACATATATTCCTCATT rsl295139 AGTATAATCTGTCATG [A/G] AAGCTCGACAGAAAGA rsl532885 AGTCAGTATATGTAAAtA/GlTGAACATTGTTTTGGT rs2425754 AGTGGAAAAACAGTAA[C/T]ACAGAACATAGACGGT rs2554622 ATAACTAACTATAAAA[AZC]CCAGCATCTAACATAA rsl7459837 ATAATAGATGTAACAA[AZT]GGCGATGATGTAATAT rsl2294573 ATCTATAAGGACATTA[A/G]GCCAGAAATAATCTTT rsl389798 CAAATCAGGGCAAAAA[G/T]TCAACAGCTTCTGCCC rsl602007 CAATTGTTGCAGCAAA[C/T]TTCATTATCATCTTCT rsl630807 AAATCTCTAAACTCTA[A/C] ATTCCTGTG CTTAAGA rsl3287677 CACATTCTGTAAAATAIA/GIACATTCAAGCCTCATT

rsl878266 CATACAAAACGACATA[C/T]GTTGGCATTTGCTTTT rslO8O7224 CATGTTATCTTCGTAG[A/G]AAAGCAAGGGG AGTTC rslO131139 CATTTTGTTTCATTAA[C/T]CCAAGACTTAATTTGG rsl868727 CCACTAATAGATAGCA[A/G]TAACATCAAATGTCAA rslO77776 CCATTGTAAGGACTCA[AZC]AATCTATACAGGAGGA rsl7027171 CCTAGACGATTGCATA[A/G]CTTAAAAAGGGGCATG rsl726673 CCTGAAAGCCATAAAA[C/T]AACTGCTAAG I I I I 1 C rsl433242 CTATGTAATCAAGTTA[AZT]CCTCTGCAGCTTGCTT rslll25644 CTATTTGAAGGTGAGA[AZG]AGGAGTGGACAATATA rsl0873339 AACTTCCTCAATTTTG [A/G] AGGCTCAAG ACTTCTC rsl348557 CTGAAGTCACCCAGCC[A/G]ACAGGAAGTCCTACAT rsl776046 CTGTGGAAAAATCTGA[A/G]TACAGCCTGATATTTG rslO851817 CTTCACCACTTTGTTA[A/T]ATGGCCCCTCGGTTTA rsl0233697 CTTCTTTCAGGATGGA[A/G]AAGGCACTAGAAGAAG rsl6944155 CTTGCAGACCATTTTA[A/G]GGAACACTTGGATGGA rsl520472 CTTTCAATATTTATGA[C/T]GTTGTATGTGTGTCTG rsl7680407 GAAGTGTTAGTGATGA[CZT]GGACAGAAATAGACAA rsl0108431 GAATACATAAGTAATA[AZG]AGACTATGAGAGGACA rsl6839198 GAGACGTAGAGTCAGC[GZT]CCTGGTGTCTACCCCA rsl7154998 GATCAGTTTTATAAAA[AZG]GATAAGTGGCTTTTCA rsl924022 GATGATATTTTGACCAIA/GIGGTTTGATTGAATCTG rsl0519003 AGCTCGATCCAGGTTA[CZT]GAAGGTGTTTCCCAAG rsl0091799 GATTAAAGGGCACATA[AZC]AAATGTCACTGGACAG rsl0519051 AATAGTCATAGCAGAA[AZG]TAATACTGATAATATT rsl241929 GCAATAGCTCAAAAAA[AZT]TTTTTAACACTATGAC rsl2640317 GCCCACATAAAATGAC[AZG]AACTTAATCTGTAAAT rs2037382 GCTCTAATTAAAAGAC[AZG]CCTAAGTCAGAGGTCT rs2344863 GGAGCCCATGGAAGGA[CZT]GCCAAAGGGCGCAGCA rsll982195 GGATACCTCATAGTGT[AZG]AAAAAATGTGAAAATA rsl747062 GGATGGCTCCAAGAGA[CZT]GTCTGACTTAAGCAAC rs2290482 GGCACACACCTACCTA[CZT]AGACATACAGTTTCAG rs2389316 GGCTCCTCGTTGAAGT[CZT]ACCTCAAGCAGCCTGA rsll743536 GTAGCTCAGATAGATG [GZT]AGACCTGAATAAATTT rsl362400 TGCCAAATTGAATGAT[AZG]TATTTTCACATCCTGA rsl6923831 GTTCAAGGTCTCTTAA[AZC]CATCCTTACTTCACTT rsl842474 GTTTCAACCACCAATA[AZC]CCTTGTTGTTGTGACC rslO514479 GGCAACATGCTAGAAA[CZT]GATATGATAGGCAAAA rsl0153806 TAACTTGGCTTCATCA[AZG]AG I I I I I I GTTTTGTT rsl0947855 TACAAGTCTACCAAAC[CZT]GGGAGTGAAGAAAGGA rs2024055 TACACTG AAATTTTAG [GZT]CCATGTTCACTTATTA rs2131432 TAGCCACATGATCATA[AZG]AAAAATCTCTCTCTCA rsl3339550 TAGGAAAATGGTGGTA[AZC]AATCAATATTTAGAGG rslOO14281 TAGTGAAAACCCAGAT[AZC]ACAGGGAAATTGGCTT rsl3101326 TCCTGGACACATAGGA[AZC]TAAAACAAAGGATAAA rsl007026 TCTCAAGGAACTGAGT[AZT]AAAGGAAACTGGGGGG rsl2309276 TCTCTATATAACAAAG[AZG]CTCATTTGGCTGGTGA

rsl2966869 TCrTCCACTTGGTCAT[G/T]AAACAGCCACAGTTCT rs2124297 TCTTCTGGCTTTTCTA[C/ηGGTTGCCATTTTATTC rs2359630 TGGATGACTGAATGGC[A/G]GACAGCAACTTCTACC rsl0439056 TGGCAGCCAGTGATCT[C/T]ACCTAGATGAGGTCTG rsl7073897 TGGGATG AAAGCATGG [G/T]CATCTCCACTTAGAAA rslll42029 TGTAGCrATCTGTAAA[A/G]CAGCTTTGTAGGCCTC rsl0982428 TGTGTACAATGTTTAAIC/TIAAGAGAGAAAGTTTTA rsl920321 TTAAAGAATTTGCTGA[A/ηTAATCTCATATTCATA rs2316310 TTAATGTACTAACCAC[C/T]GGGGAAGTGCAAATTA rsl2875231 TTC I I I C I I CAGAGAA[A/G]CTTTTCCTGACATCTA rsl2230755 TTGTGATCATTAACTA[A/C]TAGCATGTCCTAAATG rsl836630 TTTATTACATCGGAAA[G/T]GTTCATTTGTCCACAC rsl420639 TTTTAAGTAGGAAGAAIA/GJTAGAGACTCTGGAAAG rsl0081556 TTTTAAGTG AAAG ATG [A/G] AATATCCCAAATGTAT rsl6852496 TTTTCCAAAAGCTTTC[A/C]AAAATCTGACATTGAT rs2341504 ATGAGGCTGGTTCTGAIA/GJAGTGCTAAAATAAGTT rs2065313 CACCACTTGCATTTGA[G/T]GGGTATGTAACAAATT rslO489185 TGCTGTTCAAACCAGA[A/C]ACCTTGAAGTCCATAA rsl0510514 GCTGACCCACAAGAAC[A/G]CAGGGAATGAAAGGCA rsl7027581 TATATTTAATGAATCA[G/T]GTTGAAAATTCCCTAT rsl2645522 AGCTGGACTGAAGGATIA/GJATATTTGAGACACAAG rs2013685 CATATCGGCCAGATTT[A/G]ATCCAAATAAACTGAA rs2165515 AACTACAGTATCATTC[G/T]CATCTCTTACTTGAGG rsl0488464 CTGGCAGGGAAACCCT[A/G]AAATACTGCCAAAGCT rsl7072025 TCAGAAAATGCTGCAA[A/G]TTCCTGGCACTGCCTG rsl406772 AAAATAAGATGACAAAIC/TJAAATCAGAATGACAGT rslO489135 TCCTGAAAGCTGAAAG[C/T]AATCCCTATGGCCTGT rsl0501441 CAGCCCAGAGGAAGAC[A/G]CTGAAGTCCAAAGAGG rs2407492 ATATGAGTGGATGACAIA/TJATAGTGGTGTCCGGAG rsl984602 AAACTCCTAGTGCAGC[AZG]ATGTCCAGCCGAATGT rs2473091 AAATAACAGATCTAAAfA/GjTGTGGATTGATTTAAG rslll50193 AAATCAAAGCAAAGGAIA/GJGACTCAAGATAACAAA rsl947417 AACCTTGCGAAATGTC[C/T]AATTTATCAAAATAAT rsl887439 AAGATATAACGTAGAAIC/TIAATTGATTTGAGCTTT rsl0746779 AATAAAAGTATGACAGfA/GJCAAGGAAAAAGGCATA rslll73654 ATTTGCACAAAGCCCA[A/G]TCAGCTGGTAAAATGT rsll60217 ACACTCTCCCTGAGAA[A/G]CAGAACCTTTGATGAC rsl3240269 ACACTGGAGTTATTCC[C/T]GCTACAAAGGTTAACC rsl489894 ACATAAAGCACTTAGA[A/G]TAGTCCCTGGCATGTG rs2281850 ACCAGTACGTGCTGCTIC/TlACTGAGCCCAGCTCCT rsl979787 ACTTTTGGAATTCATAIC/TIAGTTAGACAGTTAGGA rsll254592 AGACCATTATATGCAC[C/T]CTGTATGCCTCTGCAT rs236369 AGCCTGGATATGACCAIC/GIATCCGAGTTCTAGAGC rsl790866 AGGGCCGAAAGAGTAG[A/C]CGAGGGCTGGTGGTCT rs2278963 AGTAGGG ATCCAAAGG [G/T]CAGAACCACTCCTCAC rsl3375764 AGTCAAACGCGCATGG[C/T]CAGTCAGTTCTGGAGG

rsl674241 AGTCTGTCCCTAAAGC[A/G]CAGAGTTGAACAAGGA rsllO47238 AGTCTGTGTTCTTTAA[G/T]GTCTTGTπTCAAATA rs2560606 ATACTGCTAATCTTCA[A/G]CGATGGGAATGGGGAA rslO189134 ATAGGGAGAATGCTCA[C/T]TAATGGTGAACATCTC rsll810706 ATCATTTTCTCTCTTC[A/G]CAGTCGCTTGGTTTGG rsl 1890075 ATTCAAGTTGAAAGTA[C/T] CCTACAG AACATCTAA rsl485926 CAAATTCAGGCTGCTA[A/C]ATATAGATGCGACAAT rsl86544 CAACTCTTTACCAAAA[A/G]AAGTGAACATACCAAA rsl91606 CACACAACAATTTAGA[C/T]GGATCTCAAGGGGATT rsl2973797 CACATGTGGGTCGTCAIA/GJCTGCCATCAGGAGTAG rsll07392 CAGTTGCCTGCTGACC[A/G]ATGGAAGAATGTGACA rslll83154 CATGTCCAAATGACTA[C/T]CTACAGTTCAAACTGC rsl342803 CCAGGGAGGGTTCATA[C/G]TAGGAGTCATCCTTCT rsl252579 TAAAAACTTGGTTCAAlA/GlGCAGGGTGAAATAATG rslll20230 CCTGCTGTGGTCTAAG[A/G]CTATTTCCCAGGGCTC rsl7099199 CCTGGCTGCTTAGACA[A/C]TCCTCCTGTTGTTTCC rsl7168936 CCTTCTCAGAGTGTAA[A/G]GACTAGCATTTATGCT rsl2497154 CCTTGAAAATTCATTC[C/T]CTTAGTGACAATπTA rsl6988954 CCTTGCTGCTCAGGAA[C/T]AATCATTGGAACTCCA rsl250072 CTAACTAAGCCCTTCA[A/G]TATTTGTCCACTCTCT rsl416078 CTAAGGCTTAGTTGGAtA/GITAAGAATAAGAAGGAA rsl332845 CTCCTTTGGCAAAGAC[C/T]ACGAATTTTGACAAGA rs2401841 ATAAAATCAAAGGATTIC/GlTTGTCTTCATTATTAT rsl2630175 CTGTGAGTGGGAACCA[G/T]GTCTAAACCCACCAGT rslO16616O CTTCACGTGTCTCTAC[A/G]CTACTCTACGACATTT rsl746596 TCGCTTTGGAATGTTA[C/T]ATAGACTGCATTTGCA rsl0050805 GAATACCAGTTCCTCC[A/G]GACTTTTGAATGCTGT rs2251680 GAATGTCAGCCAAGAG[AZG]CCCACGGAATGGCAGG rsl468405 GACATGAGAAGACGAG[CZG]AAAAGACAGGGTTTGG rsll669127 GACCAGTGACTCTCAC[A/G]AAAAGCAGCCTTTGTT rsl6895701 GACCATGTCTCAGGCC[CZT]ACAAAACAGCTTGGCA rsl7647040 GGTCTTGCTCTGAATA[C/T]GATCCTGCAAGGAGGC rs2282648 GATAATTTTGTCAGTA[C/T]CC I I I I I GTATATGTG rsl7801458 GATGTATTCTAACTTC[A/G]ATGATACTTTATTGAT rsl295142 GCAAGCATTTAATATA[A/G]CAGTGTGCATTAGGTG rsl930227 GCGAGTTGTATAGTTG[CZG]ACGAGTTGTATAGTTG rslO785115 GGAAGTTTAGCTGTAA[C/T]AAAGTGGATTTCAACT rsl2142580 GGAGAAGACGAATGTC[CZG]CAACTCAAGTAGTCAG rs6946578 TAAATGAAATGTTGTAlC/ηGCATTGTTG I I I I I I A rs4147445 TGGGTGAGGAGTATAA[GZT]GATCCCTAGGAAGATA rs6062419 TGGTTTCTACTCTGAA[CZT]GCTCCTGAACAGCCCT rs6803927 AATGTAGGTCCATAAA[A/C]TGTTTGCATTGATCCA rs7611310 AATTCTCCTCAAGTGAlC/ηCATTTACGCTTTAGAA rs6117825 AATTTTCCTAACTGAT[A/G]AGACTCTCCTTGAAGT rs895695 ATGTACTAGATAGAAC[A/G]ACTGTCCTTCAACTTT rs6663947 CTGTGTTTCTTTAAAAIG/TIATTGACAGTAGTCAGG

rs8081285 GATTCACAATCTACAA[C/G]ACCAGCCCAGCCTATC rs4732026 GGATGTACAATGTAGA[C/T]GATGCCCTCCCTGTCT rs478225 GGCAAAAATCAAGTCA[A/G]TCTGCTAATTTAAATT rs2718295 GGCAAGTAAGAAGCGA[A/G]AGGCTGAGAAGCAAGA rs705149 GGCACCCCCTGCTCCC[A/G]ATTGCTCTGAGGGGAA rs7699961 GGCACTCATAAGCCTA[A/C]ATGAAAAATTATGTCT rs7019068 GGCAG ACATTTAATTG[C/G]ACAGCTTTGGTCAG AT rs9680927 GGCCCATTGAGCTCCA[C/ηGCTCCGTTTGTCCACA rs6508322 GGCTGTTAGTACCCAA[G/T]GGCAACAACATGAATG rs4958117 GGGAAATGCCAGGAGA[A/G]GCCGTGTTCTGGGGTA rs7074555 GGGACACTATTAAATC[A/G]CAATGTCACAGGAGGG rs4126982 GGGAGAGCTAGACAAG[A/G]CCTCTATTTTTGCTTA rs9833997 GGGAGTAGATACGGCA[C/T]TATTCTGTTGAGAAAT rs6508259 GGGATACAGCTCACAA[A/G]TCTATTCTTTAAACAA rs286003 GGGCTAAAACGATGGA[C/G]AGAAATATATCATATT rs2730306 GGGTCAGCGACACAGA[C/T]GGACTTCCGTGGCTAC rs7228636 GGGTGGTATATTGCCA[A/G]GCAGAGAGGAGCAAAG rs290254 GGGTGGTTTCTAGATAtC/GlAGAATGAGATTATTTC rs2723749 GGGTTTGCTCTCAGTA[A/G]TAACCATCCCAGGCTG rs7117392 GGTAATTTGCTCAAGG[C/T]AGTTAGTAGCAGAGCC rs2685263 GGTACCTGAGGCCTCA[C/G]TAAATGCTGAAAATTT rs7539261 GGTATGAACGAGGAGAtA/T]TCATAACTGCTATTCT rs9951141 GGTGAGTCTTAAAGGA[A/T]CTGGTTGCCCAGGAAG rs910771 GGTGGTCCAGGTTCAA[C/G]TTCCTCATTGCAATAC rs4429419 GGTGTCACCATTGCTC[C/T]ATGATTAATCCAGCAA rs6021183 GGTGTTAAAATGTCAC[A/G]GGTTTCAAGATACGGG rs4333309 GGTGTmTGTGAGAA[A/G]CCTTGTAGCTGTTACT rs4236721 GGTTCATTTTCCTGCC[C/T]GCTATGTGTTAGTGAA rs355285 GTAATGCTATπTATA[C/G]AGTTGCTGTGGCCATT rs3909441 GTAATGTGTCTGTTTA[C/G]ACCTTCTGCCCATTTT rs7091802 GTATCTGCCAATGACA[A/G]ATAAACGTGTTCTCCC rs5742878 GTATCTTATAAGTCAA[A/C]ACATACATAACCCCCA rs4141692 GTA I I I I I I I GTTCTG [C/T] AGCAGTGTTATTCTCA rs36017 ATCTGGGGAGATTCCA[C/G]GCTCATGGCTGCTTTT rs6827825 GTCATTAG CACTAAAC [A/G] AATAG CAGTTAATAAC rs7900353 GTCCAAATAACCAACA[A/G]TCATTGAAATAAATTA rs7660520 GTCGTGTC I I I I I GCA[C/T]TGATTCAGTTACTGGG rs9313037 GTCTTTTGCCGCAAAA[C/T]AGAAGAAACTGGAGGC rs6849403 GTGAGGAAGAACAGGA[C/T]GTGCAACCTGTCTTCC rs4330350 GTGA I I I L I I C I I CAC[C/G] ATCTGAGCGAAGGCAG rs6683441 GTGCTATTmCTTAC[A/G]AGACATTCATTCCATT rs6802753 GTGCTGGGTGTTTGTA[A/G]AGGACTTAGCTTCCAC rs565736 GTGGTGGGCTGGAACA[A/G]AAAATGCAATATTTCA rs375973 GTGGTGGTACCTGGAA[G/T]TGGTGGTACTGACAGC rs7557611 GTGTATATCTTTCCAC[A/C]AACATATCTACAGTTT rs9385650 GTTAACAGAGGATTTA[C/T]GTGTCCCAGTTTATAT

rs7191101 GTTAATGAAAAGGAGAIC/GJAAAAACCAAGACACGG rs980748 GTTCTTCTAATGGAGC[A/G]GCAAGTCTGGCACCCG rs7307697 GTTGAAAATGATGAAA[A/G]AAGGGAAGATTCTTAT rs908366 GTTGAAGAGTCGAAAG[C/T]AATAAATGGTGGCCCA rs6136503 GTTGTG I 1 1 I I CCTTC [C/T]CCTTCCCTATAAGTCA rs7568711 GTTTATCTTCTATCCC[A/G]CAACCTTTAACGCACT rs7238329 GTTTATTTTTGTCTCT[C/G]AATACTTTAAGACTTT rs9364534 GTTTCCTTAAGGCTTA[C/T]ACAAATTGTTTCATGT rs7874294 GTTTGGCACAGTCAGA[A/C]AGCAAAAACATTGCAG rs28891 GTTTGTACTTCGGATA[C/T]AAATATGTGCATAAAA rs8047671 TTGGGAGGGTAAGTAAIC/TJTGGTTGTGATTGAAAG rs7626417 GTTTTCCAI I I I I I I C[A/G]CCATTAAGAGCAGTGA rs382888 GATGCTGTTCCTCTCA[A/C]GTGGGAAAAATTTGGT rs331742 TAAAACATTTTAACCC[C/G]ATCTATGTTTTAAATT rs6658076 TAAACATTATCAATGC[A/G]GATATTAGTAGCTAAA rs8084083 TAAAGAAAACCGAGAAtG/TJATTGGAGTTTGCTTTA rs6931162 TAAAGCAGATTAAAGAIA/GJTATTTGGCTTTTGTTT rs2740485 TAAATGGTGCCTCTAAfA/ClATAAAGGGAAATAAAA rs4733804 TAACATTACGTTTAGC[G/T]CTGAGCTTCCTAATTA rs7373237 TAAGAATGTATTGGAAlC/ηGTACTGAGTTAAGAAT rs6479352 TAAGAGCCGGGACAAA[C/T]TGATAAATGAGCTGAA rs7422754 TAATAAGCAAAGTACC[C/T]GA I I I I I IACTGATCC rs4940275 TAATG ATGGG ACTCAG [A/G]CATAAGG AAAAAGCAA rs6808691 TAATGTGTCAAATAGTIC/GJAAATCTAACAAATAGA rs7213824 TAATTAGGATGGACAA[A/G]TAACACCAAACTAGCT rs7568164 TAATTTGCCCATGATC[A/G]GACACAATTTAAGAGT rs6957385 TAA I I I I I I IACACCA[A/G]ACATCTAAAATTATTC rs7966105 TACAAATAGGACATCAIC/TJGAAAACTGCATCAAAT rs4608810 TACAGATCAAGATGTC[A/G]ACAAGGTTGGTTTTCT rs3785157 TACCTCTAATGCACTC[C/T]GAGGACCCCAAGCTTT rs7184960 TACGTAGGTTGTATCT[C/T]AATAAAGCTGTCATGG rs9409699 TACGTATGGGATACTA[C/T]ACTGGTGAATATAAGA rs9574187 TACTCAGTCACAATAA[A/T]TGAGATTCCTGTTTGA rs7838821 TACTCTCAAAATGACC[G/T]GGGTGGTGAATCGAAC rs6013694 TACTTGCTATTCACTA[C/T]GCTGAAAACTTTTATT rs271012 TACTTTGTAATGGAAA[C/G]AGCACTTGGAAGAGTT rs7139910 TAGAAGAATTTTAAGAtA/ClGGCTTGTGATATAATT rs2974658 TAGAGAAATAAATGCC[A/C]CTTGTTGTGGTGAAAT rs9973427 TAGATGGTATTGATACIA/CJGAGGTTAAAGAATCAG rs4821283 TAGCAAGTGAGAGAAAIA/TJTATCTTATCGGGGTCA rs4387746 TAGCATAAATTGCCAC[A/G]CTACCAGCTAATTGAC rs4336286 TAGCCCTAGCCAGAGG[C/G]AATCGCTCATCCTAGC rs9296044 TAGG ATGCTTTTGCAGlA/ηAATTAACTTG AGTGG A rs6891806 TAGGGTTCGTAGAATAIA/ηGAGTGTTTTAGAGTGA rs859232 GGGTACCATGCCTATC[C/G]AATTTGACACATACAA rs859234 ATGAAAAGGATAGAAAIC/GJAATGGAGTGGAAACAA

rs7004124 TATAAGGATAGAAAGA[C/G]AGGATGTAAACTCAGA rs6444003 TATAGTTAAAGGTTAA[C/T]GGCAAATACTCATCTC rs912369 TATCACGTGAATAGAC[A/G]GTAACCTTTAATAACC rs4756093 TATCCTCTAGAACTGC[A/G]AGGAAACAGATTTCTG rs3773383 TATCGTGCTTAACAAA[A/G]GTAATGGGGACTGTTC rs6503352 TATCTATGCAGGCAAA[C/T]TCTAGGCCCCAAGGCT rs6923212 TATGTAAACTGTTCCA[A/G]AAGGAATATGTTTACT rs9850420 TATGTAATCTTACAAC[A/G]CGAGTAGTTCTCTGAA rs5008854 TATTTGATGGTTAAAA[C/G]TGCAGAATGTCGCTTA rs9597493 TA I I I I I I CATGCTGA[C/T]CCTGTGTAAGTCTTTG rs9469240 TC AAATC AAC AATCTC [A/G] CTAC AC ACTCTTATC A rs2840588 TCAACAATTTGCAGAC[G/T]CTTACAGTTCTCTCCA rs7177664 TCACAGAAACATACAG[A/G]CATGCAAAGGGCTCAT rs2654981 TCACATTTCAATGGTA[C/G]GAAAAGTGGCTTCGTA rs9288989 TCACCTAGTCAAGAAA[A/G]ATTAATCCACTGCCAA rs9875156 TCAGATCCTTGCCAAG[G/T]AGAAACATTTGATAGC rs9851360 TCAGCTTTATTAACCA[C/T]GATCTTGCAAAAAAAG rs748165 TCAGTATAAGGTTTGA[C/T]GTTGACATTTTAACAA rs6933331 TCATAAAGTGAGTTTG [A/G] ATCCTG AAG AAGCCAT rs4620786 TCATTGTG CAATATAC [A/G ]AAGTGTAAAAC AAAAT rs6663410 TCATTTAGAACTTTCAtA/GlAAATGGATAAAATAAT rs2975272 TCATTTGGTGCCGACG[C/G]CCTAGAATCACACAGG rs485056 TCCAAAAGTACTTTCG[G/T]ATTCCTGGCCTGTACA rs9815517 TCCATCACAATAAACC[C/T]CTCTTGGCTCCCTTAT rs2860662 TCCCCACCTAAGTCGAIA/GIACAGTATTATCAAAAC rs2736172 TCCCTGTCTTTGGACA[C/T]GTAAGAATTGGAGGAA rs3897474 TCCTCTGCCATAAGCC[A/G]AAGACATTCACCAGTC rs4943980 TCCTTCL I I I I I I I CA[A/G]CAAAGTGAGATGCAGA rs9547919 TCTAAACCAGTTAAGC[A/G]GCAGAATAAATGTGCA rs9379660 TCTACAGCATCTTTGC[C/G]AGTTCACTGAAGCGCT rs9967822 TCTACTCCTTCAAAAA[C/G]AAGACTCCAGTGGCTA rs4091356 TCTAGGACCACTGTTA[C/T]GATTTAACTTCATGGA rs6431547 TCTATTCACTCTAAAA[C/T]GGCAGCAGGGTTGAGT rs4896449 TCTCATTGGAGACATA[C/G]AGCTTAAGCAGGCGTC rs4980715 TCTGAGAACATAACAG[C/G]ATTCTAATGTGTTGGC rs4716626 TCTGGCACTAGTAACA[C/T]ACAGTGAACATTACAG rs4118375 TCTTCCTCAACAGCCA[C/G]TGAATCAGTTCCATCC rs7014251 TCTTGGTCATGGGGAA[C/T]GGGCTTAGAGCTTCCC rs4744280 TCTTTAG CATATATTG [A/C] AATTCAG ACC I I I I I A rs9276431 TGAAAAGTGGAAGCTC[A/G]ACTGG I I I I I I AATTT rs9822356 TGAAATGACCTGAAAGIA/GIAGATTTGCATATATAG rs4615248 TGAACACAAAGGCCAT[A/G]AGAAGAGTGTTTCCAA rs932396 TGAACCTGGACTAGAA[C/G]ACAGAATAAACTATGA rs4694381 TGAAGATAATATGAAqC/GJGAGTGAGATGTAACAG rs7565023 TGAATATTTCTACACA[A/G]TAAATGCATAAGTACA rs5755255 TGAATTCTCGGCAAAA[A/C]CATCCTCTGAGTCTGA

rs7912876 TGACmTATTTTTCA[A/G]TCTCATCCTTATCAAC rs9477555 TGAGAAATGCTGCTGA[A/G]CACAGTTAAATATGGG rs7203172 TGAGAACTACCCAACT[A/G]AGCCAAAGTAACCCAC rs2743208 TGAGAATACAGCTCTA[C/T]GGATTTTGTCAAGTGT rs2789416 TGAGTTAAGCACCTAA[A/C]AGGAGTTTGCTTCCAT rs4877934 TGAGTTGGCTGAGGCC[C/T]ATGTTAGCAGATGGGG rs6440677 TGATACTATACTGTGA[A/C]ACATGGTAAGTATTTG rs7017087 TGATGACATTATAAAAIA/GJGAAGAGAGACAGGAGC rs7236339 TGATGCCTGCACAGCA[C/T]GGCGGTTGGAATTCAT rs6065525 TGATTAAACTTTCTAC[A/G]ATTTATGCGCAACACT rs7236071 TGATTCTGGGGATAAA[A/G]CTGTGAACCAGATAAA rs7119964 TGCACTGCCAGTTGCA[C/T]AAAAGTATAGCACATA rs7127861 TGCAGCTAATCTAAAA[C/T]GGAGAATAGAGAGCAA rs4952521 TGCATCCAAGGGCTGA[C/T]GAATATTTGCAACACC rs3019442 TGCATTAAAATCTGTA[C/G]CAGGAATCACTTCTGC rs7631170 TGCCAACATAACACCA[C/T]GAGTGGAAAATTCCAC rs4766526 TGCCAGAGTCATGTGA[A/C]CTTGTGGAGTAGATGC rs7967892 TGGAGGAAAACCTCAC[C/T]GACTTGGCAACATTTG rs9517529 TGGCATTTGG AATAAG [A/G]CTAAGGTGTGTGTTCT rs914947 TGGCTTAGATTCATAC[A/G]CTTTGGAGTAGAAGTG rs901036 TGGGAGACCCTCGATG[C/G]AGGTTTGTGGAGGGAA rs4147445 TGGGTGAGGAGTATAAIG/TJGATCCCTAGGAAGATA rs4731517 TGGTAATTGGCTTCCC[A/C]AGCTAGGTTTTCTGGA rs7748736 TGGTCTGAAATTGAGA[C/T]GCTTATTGAATGCTTA rs7176986 TGGTGGACCATGGATG[A/G]ACCCAGTTACAGGGTT rs3901856 TGGTTACTAAGGTGCC[A/G]ATTCTCCCAATACTGC rs6062419 TGGTTTCTACTCTGAA[C/T]GCTCCTGAACAGCCCT rs6593482 TGTAAGTCATGTATCC[G/T]ATTAGAGACTTCTATC rs4985702 TGTAGGTGTGAAGGGCIA/GIGAAGGATGGAGATGGT rs6664939 TGTAGTAGAATGATCC[A/C]AGTCCTAATACCCTAG rs6959558 TGTAGTTTCTAAGCAC[A/G]ATGTCCTGAAAGTCTG rs7139858 TGTCAGTCCAGAGGAG[C/T]CTACAAAGATATGACA rs4514740 TGTCCATACTTGTGGA[A/C]G I I I I I I CTATTGAAG rs7673088 TGTGGAAATAACAAAAlA/GjTGGGATATGAACCTCA rs9290927 TGTG G CTCACGTGTAAf A/T] GTCTCTG AATTTCCTT rs4920424 TGTGGGCAAGTCACAC[A/T]CATGCAAATATGTGAG rs845083 TGTGGTTCTAATGCAC[G/T]AATTAAATATCTGTCT rs3915457 TGTTGAAATTTAAGGA[G/T]ATATAACTCTTGACAC rs7795090 TGTTGTAATGTTAGAAfA/GlAGTAGAACAGCTTGTG rs9319065 TGTTGTTGCGTTTCAC[C/T]GCTGGG AAATGG AAAG rs9592445 TGTTTTACAAATAGTA[A/C]CCTTTACAAATAGTAA rs535902 TGTTTTCAGAGATATC[C/T]ATCTAATCTTCCTGAT rs2960744 TGTTTTCATTATGCTA[A/T]GTACAAGATTGTGCTA rs274231 TGTTTTCTGTCTTGTA[A/G]ATTTCrGTTACTCTTT rs7528328 TTAAAAAGAGTGAAAAlA/GlTAGAGGTGCAAATCCT rs9900205 TTAATCTCACCATGAA[A/T]AGTCAAAGAGAAGAGG

rs794783 HACCAATGACCAAAA[A/G]CACATACCAACGTAAA rs3734974 TTACCTCCTGGGTAAC[C/T]GGTGGAGGTAAGTGAT rs6489600 TTAGATATTAAGGTCAIA/TJCTGAAACTTGATAGAG rs332607 TTAGGTCCAGGTTTCT[C/T]AACAGCAGTGCTACTG rs6455807 TTAGGTGTTTCCTTGC[C/T]AAATTAAGCCACTTCA rs4893998 TTAGTCTTCTATATCA[A/T]CCAGAAAGAGGTCCTT rs7579000 TTATCAAATTTTCAAA[A/G]TTACTCACGCCATCAC rs9363771 TTATCTACTGATTTAC[A/C]CAATTTACAGAGCCAC rs4922950 TTATGCCAGACTATAA[A/G]GCAATATTTAGGAATT rs4501020 TTATGCCTCTACCTCA[A/G]ATTCCTCAACTAGGGA rs7843358 TTATTAAACATGATAC[A/C]CAAAGTACAGTGAAAA rs7652049 TTATTTCTAAGTAAGG [C/T] C ATATTC ACAG GTACA rs6413416 TTCAAAACTTACTATA[A/G]CACTGCGGTAATCAAG rs7969971 TTCACACAACTACCAA[C/T]GTCCAGAGGCGGGATT rs7908867 TTCACCTCTTG ACTTG [A/G] AGCCTTATAAACTAG A rs735447 TTCACTTGGAAGAAAA[C/T]GTAAGCAAAAGTAGCC rs7807871 TTCCACAAATTGTTAA[A/T]CAAACTTTCTGTAGAA rs6069864 TTCCACTTCAGCTGTC[A/G]ATCATACACTTGCCCA rs8088357 AAACTACACATAGCAA[A/T]CCTCAAATTTGAACAG rs7238071 TTCCTGTTGAGGGCAA[C/T]GGAAGAATTTGGCAAA rs3753305 TTCGTTCCTCTGGTAG[C/G]AATTGTTGAGTCAAAA rs6018685 TTCTCTTGCAAGCAAC[A/G]GAAAAAGAGAAGAAAA rs5755254 TTCTGTAGGACATCAA[A/G]ATAATCAGTTTCCTTA rs4583865 TTCTTTGCTATCTTCT[A/G]AAAAATTCACCATCAT rs4704859 TTC I I I I I ATTGGCTA[G/T]CTTTATGTTCGCTTTC rs6049828 TTGAAACCTGTTTCCC[C/T]GGAGCTGACACAGGGC rs6780822 TTGACAGTTTTCCAAG [A/C] AG AATTAAG GTTTCCA rs4775698 TTGCACAATGTAAACC[A/C]CAGGACTTATGGAGAA rs4710013 TTGCGGGTTTGTATGA[C/T]AGAGACAAGAAAGCAC rs8098626 TTG CTTCAG CACTCTA [C/G] CAAAG G CCAACCTCCC rs4355836 TTGGGGCCAGGAACCA[G/T]CCTTAGTATTCAGGCA rs6545316 TTGGTTTCTAACTAAC[A/G]CAACGTCTAAGAAGCA rs7334517 TTGTGTAGAGTAACTC[C/T]ATGCGTAAACAGTTTC rs6891143 TTGTTCATTCCACAAA[C/T]AGTTGTTAAGTGAAGG rs7191770 TTGTTTGGTTAGGTGGtA/ηATAGGCAATATTCTGA rs7355631 TTGTTTGTTTTTAAGA[G/T]CTCTCCAAAATCTAGA rs3980634 TTGTTTTGTATCATGG [A/C] AAATCCTGACAACATG rs33612 TTTAAAAAACATCCCA[C/T]TGACTACAAATGGATG rs35489914 TTTAAAATGTATTGCA[G/T]AGTmTGGCTTATTT rs4890773 TTTAACCACAGTATAA[C/T]GCCTTTCAAAATTGGA rs6852493 TTTAATATCAAATGTG [A/T] AATAGG AAATGTATTA rs7679643 TTTACCTTTTAACATA[C/T]CTGGAATTGGAATGTA rs7035425 TTTACTGTGCACTGAA[A/C]AGGTCTCTATATTTTG rs7746960 TTTAGAACATGTAGCA[A/T]CATCTTAGAGGTCTAT rs9362068 TTTAGTAAGACAATTC[A/G]CCTAACAGATAAGAAA rs722740 TTTATGATAACTTGCC[C/T]ATCCAGAAATGCTGAG

rs6785972 TTTCCCCAGAACGGTC[A/C]AGATTCACTGACAGAG rs6427900 TTTCTACACCTCTCTC[A/T]GAAAGGAAATGTCAAC rs4449085 TTTGAGAAAAGAGAGAIA/GJAATAGCATGAATGTTT rs2912020 TTTGCTAAAAGTCTTC[A/G]AAAGATTTGCCAAGTT rs3741098 TTTGCTTGCAAGCGAA[C/T]GGCTTCCCAGGGAGCG rs5765398 TTTGGTAGCTCATAAA[A/T]TCATCAGGAATACTGC rs6448604 TTTGGTGTGGCATCCA[C/G]TATAGTCTGTTTAATG rs6139427 TTTTACAGGTGAAGAC[A/G]CTAAGACACAGAGAGG rs2673891 TTTTGCCTTAATTTGC[A/G]CAATCATTTCCATATT rs7184076 TTTTTAAGATGATTGAIC/GJAGACTGAGTAAAAGTT rs2955262 TTTTTCTTTGCTTCCC[A/G]GATATTAGCAGGGAAG rs9937452 I I I I I I GTGTGCACAA[A/C]GGTGACTTTACAGCCT rs614281 ATCCGCAGGGCTGTCA[C/T]CTTTTCTCCAAGCTCC rs6713 CCCTGGGTCAGCGCCA[A/G]AAGAAAACCTGGAGGG rs3769177 TTCCCTTTGAGTTTTA[C/G]GGTGATAATAGCTGGC rs6761003 GACTAAAATATTCCTA[C/T]GTGTATTCAATCAGTT rs4586627 C I I I L I I GAAACTGAC[A/G]GCAACTCCAACAGCTC rs6086072 TGGTTCATACCTGACT[C/G]AATTTCATTTTTAATT rs6016864 GTGTTAAAGTACCAAA[A/G]GCTCCAATTTACTAAG rs2789417 TCACGGTAGACACATA[G/T]ATTGTACTGCTGCATG rs4347903 AATAAAAGGCTGTGAC[A/G]GAGACTTTAATGGGGC rs2824431 TACAAATAC I I I I I AA [C/T] G CCACCTG G CCAATTC rs9976697 AGAGGATTTTCGATGAfA/ηGTGAATGGCAGGAATA rs988292 TGTACATACAACTCAT[A/G]AAATCTACATACATTA rs2837018 GATGCTTAAGAAATAC[A/G]CTGTTTCAAGCCTCAA rs2837257 ACTGTGATGAAGATGC[A/C]GACACTCCAGGATTCA rs6426898 AATAACTTCTGCTACAIC/TIGCAGTTTCTCAAGACC rs2839580 TTGCATCTTTGGGTTAIA/CIGGCTCTGCTGCCCTTG rs737809 GACAGAACAAGACAAA[C/T]GGCAGGTGGACTTGGG rs414989 TCCTCCTGAGCTGGCC[A/G]ATTATTTTCTGCTACT rs6782967 GGAGTTGGATAGCAAT[AZG]ATATTTAACAGTCATT rs951678 CAAGTGCTTCTTCATA[G/T]CATGGTAAGAAGACAT rs704829 CAGGGCACAAGCTGGA[C/G]GCAGCAAATGGGCAAA rs6791614 ACACTATTGGTAAACA[A/G]AGCAGAAGTAATGTCA rs2895395 ACTTACTGAAGCCTGA[A/G]ATGTAGCCCATTAATT rs4355254 AAAGG ATAC AG CCATG [A/G] CAAAAGAG G AAACATT rs2862824 TAAAATAAAAATAAAAtA/TlGACTCAAGTGTACATG rs6817648 TCAGCTTAGGTCTCTT[C/T]AAACGTGTGCAATCAT rs29336 AAGGAAGAGTTTGACA[C/T]GAAGTAAAAGTCTCTG rs4600972 TGAAGAGGAGAAAAAC[A/G]CTACATAACGTGCTAA rs7547363 CAAAATGTTGCTTTTA[A/G]GTCGAGATCAGGTAAA rs6837016 TAATAATAAATCATCA[A/G]TCCCTTCGTGAGTGTT rs325032 TCTAATACCTGATGAC[C/G]TAATC I I I I I ATTGCT rs380259 TAGGGGCACTTTGGGG[A/G]CATTTTGGTTTGGCAT rs32710 AGCTAACTAGGCCAAA[G/T]CTAATAAGGATCATGA rs309572 ACCAAAATACAAGGCA[C/G]TGAAATCTGGTGCATT

rs569733 TGACTTCTGCTGTCCA[G/T]GAGCTTATAATATAAC rs3777048 CTTTATG GTTCAAAAC [C/T] AG AC AACAATTACTAT rs4391218 ATATTGGTTTCCCCAG[C/G]CAGTCA I I I I C I IAGG rs2706364 CAAATATTACTGTTTG [C/T] ATCCAACAAGAG AAAA rs34170515 TCCAAATCAAGATTCC[C/T]CAGACATAGCTTCATA rs3776069 TGCTACCAATAAACAG[A/G]AAGGAGGATTCTTGTA rs7768538 CTGCGAAACCCGTCCA[A/C]GCGAAATTGAGTTCTT rs4594945 TAATGGC I I I I I GCTA[C/T]CACAACTCCTCCTCCC rs9320994 G GTGTATTG CCCATG G [C/T]CAGAG AGG AAATTAAG rs627629 GTCTATTAGATGAACA[A/G]CTACAAGTCTCTTCTA rs6465147 GGCATTGACATCTTTA[C/T]GAGTGACTTTCCATCC rs727164 ATACTGAAGCAACAGC[A/G]ATCGTATTCATAGTCA rs3779258 TCAGTCTCTAAAGTAA[C/T]CAAGTCAATTCACTAT rs6560771 TAATTTTGGTGTCAGA[C/T]GTTAAAAATGATAGGG rs4737321 AGAAAATCGCGTAAGA[A/T]GTCAATATGCTGTTTA rs930148 TAGGAGCTTAGCTCTC[C/T]CGACTCTCGGGCCACT rs9299582 AAAGTAGAATGTGATCIA/GJAAAAAACTCTCAGTTG rs4279792 GCCAAACTCACAAAGA[C/G]CTTGAAAGTCTCTCTC rs4641492 AAGAGATGTATTTCAAIA/GIATGCGAAATTAACAGT rs4781958 CTGTAGACACATATGA[A/G]TCAAACACCTGTAAAC rs4239268 CTCCTCGTAGTACAGA[C/T]TAATTTTCAAAATAGT rs363314 TGGCTGCCTGGTTGTC[G/T]CTGATTGAATGGTCCT rs4368343 TTGGTGCCATCTCTTT[C/G]AAAAGCAATTGAAAAT rs7558224 ATGAAAACATTTTGTAtC/TlGGGATCTGATGATTGA rs6014814 ATTAGAGACTGGGCCAIA/GJCTGAGTAGCCACAGGG rs7621243 TGCATTGCAAAACTCT[A/G]AAGAACAGCATTCTTA rs6442055 CCAGACAGTCTAACTC[A/G]AGAGCACTTTTATCTT rs2932966 GAATCTCACTCATAAA[A/C]ATCACCTCTGAAAATC rs4864949 TTTAAGTGTTGATTGTIA/GlAAACAAGACAGATTGG rs6554923 AAGAAAAACAGAGGAC[A/G]GGAATTACACAGGTCC rs966905 TTCCCCTTTGTTAGAA[C/T]TGTCCTCTTCTCTGCA rs6465386 AACATTTAAAACTACA[A/G]ATAGCACTGCAGCTTG rs7780181 AGGTCTAGGTTAGTTA[A/C]CACAAAAGTAGGTCAT rs4286971 TTTTTGCTATTTGCAA[C/T]GTCACAATAGTTTTAA rs6998580 TTC I I I I I I CAAACCC[A/G]AGCAAGGAAAATCAGA rs6477872 ACTTTGCATCTGTAAC[C/T]AACTGTGATCCTCATT rs2824582 CATGGTTTGGATTTGAtA/GlGAAAGGAGGAGTGCAA rs2824592 GAAGCACAGAAGGAGAIG/TJGAAAGTGAAATAGCCA rs9984988 AGCA I I I I I GAGTGCA[C/G]AGGTAGGCAGGAAAGA rs4816801 ACTCAGAACTCTTGAC[A/T]AATCATGTAGTTTTCT rs2825891 CTGATGAAGATTTCAA[A/C]ACCTGGAGAATATTTT rs2829276 AAACTTGTTTTCTTTC[A/G]CTTTCTCCGGCTTTAT rs2829819 CCTAAGAATTGTGAAAtA/GlTTTACTGATTAGAATT rs9977087 CTGTG AGG AATGCTAG [A/G] ATGG AAATGCTAATTA rs2831366 CCTATAGACGTTTTTA[C/G]GAATTTGGATTTTATA rs2833256 CACAAGGTAATGTAGA[C/T]GGGCCTCAATCCCAGG

rs2834136 TCTGTTGTTTTCTATA[A/G]GTTAGATTGCCCATTG rs2836357 AAGCAGCCTGTGTGCA[A/C]GTAGAA I I I I I I I CCC rs2836365 TAGCAAATGGCTAAAA[C/T]TGCATTCTTTGCTTCC rs2836658 AGGGCCATAAAACTGA[C/T]GGTGCAAGCTGAAACT rs9305744 AGGCAACAGCCAAAAA[A/G]CCGATGGAGTCAATGG rs9981276 TGAGGGGTTCCAGTTA[A/T]CTCTTTTCTCACCAGC rs726601 TCCATTGTCAGCCTTC[CZT]GAAAGGACTTGAGATT rs4571397 AAAAAAATTCAGCACC[G/T]GGAAATCAACATTTTG rs7073811 AAAACAGAGGACACCT[A/T]AAAATGATAAGGCCAT rs3770887 AAAACTTTCTAATTGA[CZT]GGAGTGGCTGTAGTTT rs4870752 AAAAGGGAACAAACTA[C/T]GCCACTACCTTATCAG rs2926862 AAAAGTTTATTAAATA[A/C]GTACACAGAGGCCATA rs3796473 AAAATCTTTCTACTCC[C/T]ACTGAATTCCTCAACA rs9360790 AAACAATATTTTCAAA[C/T]GTCCTCAATAAAATAG rs7872232 AAACACACTCTCTTTC[A/G]CTTAAGTTTCTTAACA rs9506890 AAACCAAACAAAGCAA[A/G]ATAACACAAAACTTTA rs9346035 AAACTAAAGCCATTAA[A/G]GTGCGTATAAAATTGA rs5009801 AAAGCAATGAAACTGA[A/G]TAAGTCAATTCTAGAA rs4859543 AAAGCCAGGCTTATGA[A/T]CTAACCAGAAGTGCAG rs331783 AAAGGGATATAATAGA[CZG]AGAAATGGTTGAAAAA rs3766084 AAAGTAAACAGTTGGA[CZT]GGAATTTTATCAATTG rs836474 AAATACAGGTGATCTA[A/C]ACAAGGGAAGATGCTG rs888152 CCTGGGCCAATTTGCA[C/T]CAGGTACAGTTGGAGC rs3852539 AAATAGTCCTTAGGCT[C/T]AAAAGTGGTATATGTT rs7178130 AAATCTCCCGGAAGAA[A/G]GACTGAATTAAATGCA rs4876626 AAATCTTGTTATGTAG [A/T] ATCG AATCATGTG AAA rs7195806 AAATGGCCCAGGCTGC[AZC]AAAAAGGGGAGCAGCA rs558692 AAATGTCATCAATCAG [A/C] ATTTTC AGTAAATAAT rs7557853 AAATTACTAAATGTGA[A/T]GTTGATCAGAAACACA rs7245762 AAATTCTCACAACCAC[A/G]ATAAGAGCTAGGTACT rs6802715 AAATTTAGCCTCCAAG[A/T]AGAGATCTGCTCCAAG rs4918029 AAATTTGGCCACAGAA[A/G]CTGGCTAGGAAAAAAC rs9276432 AACAATTATAGGGTAC[A/G]AGAAAGACTATTACAA rs722248 GCCCACCATTTAAGTG[C/T]GATAATTTGTCAGTGT rs6432655 AACATTCTTGTGTAGG[C/T]CCAG AAAACGG ATTTA rs4810366 AACATTTGAATTAACA[A/G]TCCTTGCTGTGTGTGT rs303765 AACCAAGAAGCACTCA[AZG]TACATGCTCCATACAT rs896932 AACTCACGCACGTGAC[AZG]ATATTAAAGGACCCAC rs9391062 AACTGCTGTGATCCAAIC/TIAAGTCTAAGTAATATA rs4275832 AACTGTTAGAAACATA[C/T]ACAAACAGGCCTCTTA rs654694 AACTTGCTCTCTCAAAlC/ηGGAAACTGGGACCCTC rs941845 AAGAAAGAGTGTTTCC[AZG]AAAGTGAAAGGGAAGA rs6575613 AAGAAGGCCTCGTAGG[AZG]AAAAGAAATGGGGGCA rs6485030 AAGACTGCAAAGCAAC[CZT]AGCTAAAAACACCAAG rs9919707 AAGACTTTCATCCACC[AZG]GAAGGGCATATCAAAA rs9384257 AAGATCTGTTTTTCTC[CZT]CCACACATTCGTCTAG

rs9872164 AAGCTGCATAGATAGA[CZT]AGTGAGCCTTCAGCTA rs7750679 AAGGAAGTAGCCTAGC[AZG]ACCTACAAAAATCTTT rs741195 AAGGAGGGGTTAAAAA[CZG]TAGCTGAGCATGATGG rs7790213 AAGGGACAGAATGGAA[GZT]AGAGAGTATCAGAGTA rs4541896 AAGGGAGAGGATCAAA[AZG]TTACCTGTTCAAATAA rs914993 AAGGGCAACTGGAAGA[GZT]GAAGAAGAAGGAGAAG rs2698119 AAGGGGAGATAGACAA[AZC]ATAAACCTGCAAGTCA rs9813365 AAGTCCCAGCTCTTGA[CZG]GTGTACAAGATGAGAG rs323684 AAGTCCCTAGTAAAAG [AZG]CATAATAAATGCAAAT rs886750 AAGTGCCTCGGATCTC[CZT]ACTTTATCTGTTAATA rs574695 AAGTTAGCCTAAAACA[CZG]AAATTCAGGCCATGAT rs3853184 AATAACGGAAAGACCT[AZG]AATTTAAGAGGCTTGG rs7093687 AATATTGATGAATCCT[CZG]AAAAAATGCTAGCAAA rs9770283 AATCAGAAATACTTAA[CZT]GTTGCACTTTCGGTCA rs4504949 AATCTATGTCATGTTC[AZG]AGGCAGAGACAGATGT rs939971 AATCTCTGAAAGGACA[AZC]TAGGCAACACAGCAAA rs4393279 AATGTAAATCTGCAAA[CZT]GCCTAAACTTAAAAAA rs6803927 AATGTAGGTCCATAAA[AZC]TGTTTGCATTGATCCA rs8107919 AATGTTTGCCGAGTGA[CZT]CCCATGAGCGAGTGAT rs540391 AATTCATAACTATAAT[AZG]AGCATCAAGTTAACTA rs7611310 AATTCTCCTCAAGTGA[CZT]CATTTACGCTTTAGAA rs6936420 AATTGCTAAATGAGCC[AZG]ATGGACTTAAATCAGC rs2913929 AATTTCCCCCAATCAA[AZT]CAATCTTTACCTACAG rs5997780 AATTTCTTTTCAGCCC[CZT]GAGGTACATATTTTTT rs9469220 AATTTTATATTTCTAC[CZT]GGCAGTTTGAATGGTA rs7581204 ACAAAATGAATGATGA[AZG]GTTAAACACCCAAGCT rs2935720 ACAAACAAATAGCACA[CZT]TGCCTTGGGCAGAGTA rs396012 ACAAGAATCCAACTAA[CZT]GTAACTGAACACTTAG rs6428134 ACAAGGGAAATGTAAA[AZG]GTGGAACAAAGCAGTA rs4235846 ACAAGTGTAACAGAAA[AZT]GGAATGACAGAAAAAA rs7330231 ACAGATTGCAAGAAAA[AZT]CTTTGTGAAGTACATA rs9886729 ACAGCCTGTGCTCAAT[CZG]AATATAGTTCTAAAAG rs7300998 ACAGCTGTTCCATCTC[AZG]ATTACAAAGCTCTGAA rs6955265 ACAGGATCTAGTGCTC[AZG]ATTGCAAGCAGGTGAC rs680209 ACATGAACACAATTCA[AZG]CTAAATTCTTTGCCAC rs7191772 ACATGCCTCCATCCAC[CZT]GAAGGCAGCCCTGCAT rs6825958 ACATTTAGATTGTTTC[AZG]AAAAGTTTACTATTTT rs9293123 ACCACAAGCAACGGAC[AZT]AGTAGGGGAAGAGTCG rs9457730 ACCATAGTTCCAAAAC[CZG]CTGTTCAAGTAGAAGC rs7760976 ACCCATTGGTTTCTAA[CZT]GATACTGGCCTTTTCT rs9901549 ACCCTTCAGTCAAGGA[CZG]GTAGACATCAAGAGCC rs473806 ACCGGCTTGCCCTATA[GZT]CCCACTTTCTTATAGC rs6991180 ACCTGAGGGAGTACCC[GZT]GAAGACAGCACACAGA rs7302315 AGCTCTGCAGACCTGA[CZT]AGATGTGGCAAATACA rs6552764 ACGCTTACAATATTCA[AZT]GTTTAACCTACTCCAT rs847386 ACTCACAACATGATCA[AZG]AATTAGGAGCAGTCTC

rs4560339 ACTCATACGTTCAGCA[G/T]TACACCATTCACAATA rs586124 ACTCCATTTATCCAAC[C/T] CCAG C AGTATC ACTG A rs6956284 ACTCTATTCCATTGGA[A/G]ACAAACCTAGGTTGTA rs9461799 ACTGAGTCCCMTGGG[C/T]AACTGATTGCCTCTTT rs730561 ACTGCAAATACATTTA[A/C]AGGAAGGAAGAATATT rs6414257 ACTTCTTG GACTATG G [A/G] ATCATTAG AAG CCCAA rs2934921 ACTTGAAATGTGCTAC[C/T]GATTTGTTATTAATTT rs7535769 AGAAG AGTACACCATG [C/T]CAGTAGTCATCAAAAA rs7193007 AGAATL I I I C I I GCTC[A/G]ATGTCTTCTCACTGTC rs809565 AGACAGTAATTTGAAC[C/T]GGATGAACTGAAAGGA rs585124 AGACTAATGTAGGTGA[G/T]AACTAGGATCCCTTCC rs4716619 AGACTCTTTTTCCACG[A/G]AACATCTTACAGGCTA rs6845684 AGACTTCAAGAGATCA[A/C]GAAGCCTGCCCAGAGT rs7563316 AG AGGCAAGGGCAACA[C/T]TG AAACAG ACCAATGC rs6930668 AGAGGCAGGGCATCCAIA/GJGGAAGAAGCTATTATG rs4766720 GTGGG ACAGCTGTTTG[C/T]ACTTAGCAGTTAAGTG rs6677463 AGAGTATGTAACTAACIA/GJACGGGAGAAACTGGGA rs7640905 AGAGTTTATAACCTAC[C/T]GACAAAAGAGCCCCTT rs7255889 AGATAAAATTACCATC[A/G]AAAATTAGCTGAGAGA rs7983063 AGATCTTTTAAGCGCA[C/T]ACAGTGAGGGTTGTAA rs6836327 AGATGAAGTAATAATAIG/TJATCAGGGTAGTCCTAA rs7145739 AG ATGTCAGTGGG AAG [A/G] AAGCTTAG AG ATCTCA rs7926001 AGATTCACAAATAAAAIA/GIGTTGCAGTTCTTATTT rs7916397 AGCAACCATTCCTGCA[A/G]GG I I I I I I I GGTTATT rs9954791 AGCACTCTCATTTACA[A/G]TGGCCACACAAAGGAG rs2936535 AGCACTTTGCTCTTCC[G/T]CACCAATGCAGTACAG rs7567280 AGCAGACCAAGTGGAA[A/C]TGATTAACCAATCTTA rs7960614 AGCATCATGTGACTCA[C/T]GAAAATTGAATCAAAA rs6672238 AGCCACCGCGCCCCGA[A/C]AAGAATTCTCTGGAGT rs6843082 AGCCTCAGAGCTGAAA[C/T]GGCTGTTATGCACCAC rs4610242 AGCCTTCAAGATTCGG[A/G]ACACAATAAGGATGCC rs9902506 AGCTGCTGTGAGAGCC[A/G]ATCATGTATCTCATGT rs8034281 AGCTTCTTGTGTAAGA[A/G]TCCTGTTGAAGACTTT rs4406411 AGGAAATATTTGAGGAμ/GlGTTTGAATATAGCCCT rs6055040 AGGAAATGGCTACAAAIC/TJTATGATTCTAGAACAG rs3948632 AGGAAGACTTTATTCA[A/G]GGCCGTTACAATAGGG rs6999409 AGGATAAAGAATGACT[C/T]AAACTCTGGAATGTCA rs4552153 AGGCAGCCTTTGGCAA[A/T]CACTACACAC I I I C I I rs4519770 AGGCTGTGGATCCATG[C/T]ATCTTTGCACTCTTGG rs6589065 AGGGCTGATTATGTTC[C/T]ACCAAGTCACTATGGA rs6770337 AGGTTTGCTTACTGTA[C/T]GGAAACGCAAACAAAT rs6825008 AGTAAGL I I I I I AGAT[C/G]AATTTATTATGGATGA rs6996688 AGTAGCTTACGAAACA[A/G]TATGAGAGCTATGCAA rs5749770 AGTATCTATAATCAGA[C/T]GTGTACCTACGTAACT rs634413 TCTCTGGATTGTCTCA[A/G]GTCTTTCCATGTACTT rs9826565 AGTGATCAGTAATCTAIC/TJAGAAAACTTGAGGGGT

rs320615 AGTTCGTCCTTCAAAA[A/C]GCATTTGCAGGACCTA rs7977693 AGTTCTGGGTAATACA[C/T]CTTGAACTGGTGGAAA rs9829625 AGTTCTTCATTAGTATIA/TIAGCTGAAATAATGGGG rs3826366 AGTTGCTTATCACAGA[C/T]GACACCCACACTCTGG rs487311 ATAAAAGGCCCTTCTC[A/G]ATAGCCACACAGCTAC rs4812858 ATAAAATAGGTCTGAA[A/G]GTACTTCCCATCATAG rs357121 ATAACCAAATTTGGGA[C/T]TATATTGGAGAGGTCT rs7185053 ATACAGTACACATTAC[A/C]ATTTGCGTCTAATGCC rs7839694 ATACAGTGTATATTTC[A/G]ATTCTATGGCTAAAGT rs2916229 ATACTCCTGTAGCAAC[C/T]GGACCAGAAAAAACCA rs7905157 ATACTTTGTG CCTAAC [C/T] ATAAATAC AAAAATTA rs7690962 ATAGATTTCCAGATAC[C/T]GCGAGGTTATTCCTGT rs9824256 ATATAATGGAATTTGG [A/C] AAAAG ATGTCTCAAAC rs4956126 ATATCACAGGTGCCAA[A/G]AACTAAGCATGTCCAA rs6912289 ATATCTAAGACATCTG[C/T]ATAGAAATGTTGTGTA rs3025657 ATATGTTATTCTCTCC[A/C]GGAATTGAATTTACTC rs937527 ATATGTTGAAAACTGG[A/G]AAATGGCTTTCTCTTC rs7243021 ATATTTCAGCTCCACA[A/G]TGAAATCATTTTATCC rs281302 ATCAAAAGAGAGTGGqA/GjAATTAGTTGGGGAGAA rs7011618 ATCAATCAGTAGAAAA[A/G]TCATTCTTGGCCTATT rs7695194 ATCACACTGTGGCATA[C/T]AGTTTCCTTAGGACAA rs4345174 ATCACATCCAAAATAAtC/T]GATTACAGTAAGGATG rs9938831 ATCATTACAGTTCAAC[A/G]GTATCACTGACTAGAT rs7830506 ATCATTCCATCAGACC[A/C]GCATTTTCTCGGTTAT rs9276429 ATCCTCGGATAAGCTC[A/G]CTGCCCATTAGAGGAA rs9443027 ATCTAGTCCCAGAAAA[G/T]GTTTCCAGGAAGATTT rs7940927 ATCTATATTCTCTTCA[C/T]AGTGATTCCTTGAGGG rs7117839 ATGAAGTCTTGACCAA[A/T]GGTACACACTCAGGCA rs9595168 ATGACACATTTTACAA[A/T]CACTATCAATGGTGAT rs2844032 ATGAGACTGATGAGCT[A/G]ACAAAAGTAGGCTTCA rs6587388 ATGCATCACTGTTCTC[C/T]ACGTGGTCCAAGTGCC rs9614868 ATGCTGAGATGTTCGA[C/T]CTTTACCCGAGGGAAA rs6720147 ATGGATCTAAGAAGAA[A/T]GGTCGATTTTTCAGCT rs4888286 ATGGCATCTAAGGACA[C/T]AAGTTGCTACGGAGTA rs895695 ATGTACTAGATAGAAC[A/G]ACTGTCCTTCAAC ^" nT rs4955385 ATGTAGTTGGCAGTCA[C/G]CCCATAGAAGTGATGT rs7801290 ATGTGCAGTTCATAAC[A/C]GCGTTCATGATCCTGT rs6913726 ATGTGCTCTGGAGCCA[C/G]GCAAATCTGCTTCAAA rs2882606 ATGTGTCACGCTACCA[C/T]GTAGAAATTTACAAAT rs2880414 ATTACCCCAATCACAA[A/C]ATGATTTATCTGAGGT rs4610413 AπAGGATTTAGCTAC[A/G]GAAAATGGCTATGAGA rs7682126 ATTCCCCTTCTGGTTG[A/G]AGATTTAGTGATCAGT rs7303573 ATTCTCTTGCTCTGGG[A/C]ACACTAGTGGGCATTT rs6438092 ATTCTGTTTATATGTC[A/G]AGCCACATTTATTGAT rs6957963 ATTCTGTTTGAAGTTA[C/T]GGGATATCCACTGTGT rs9836392 ATTGCTTGACCTTTAC[A/G]AAGTCTACTGACTAGA

rs2875681 TGGAACTGTTCCCTGA[A/G]TAACACTTTGTACTTG rs398934 ATTGGGGTACACAAAA[C/T]TCACAAATATTATCTC rs9285295 TGTAAAAATCTTTTGC[C/T]GAGAGGGACTGCAGAT rs589465 ATTTAGTAAGTGGCCA[A/C]GTGATTATTGAGAGAC rs4699668 ATTTGACTGGTTAATA[C/T]CATGGAGGCAGCACTG rs4931059 ATTTTCATCCAGAGGC[G/T]CCTGAAACAGCCACCG rs7615720 CAAAATCAGTATGTCA[G/T]CACTATTTTGGTGGTT rs5765425 CAACACCACGTGCAAA[A/G]ACCGATGCAGACTTGT rs6093764 CAACTTACAGATATAC[A/G]ATAGACATGAATAACC rs4959523 CAACTTG ACATAAAAG [C/T]AATAGCTTGG AAAGTA rs9403979 CAAGACAAAAAGTGAA[C/G]ATGTCAACACAGATGC rs6925350 CAAGATACATATCTGA[A/G]CTATCACCATAAAGCT rs902581 CAAGTTTATATATCAA[A/G]GTAACCATCACATCCA rs7236575 CAATACTGAGGAAATA[C/T]GGTTAGTTTTCAAAAG rs43216 CAATCATGTATCCTGC[C/T]ACTTGGGATGCCAGCA rs7945575 CAATCCAGAAGGTATA[G/T]GTACAATCAAATAATG rs28739424 CAATGGCCTTTGAAAA[C/G]GAAATTGCTGCTACAT rs7018271 CACAAGTAGGAACTTA[A/T]ATGATCAGGACTTTTT rs8115737 CACAGCCTTTTGTACA[C/T]AGCTTTTATGTGGCAA rs7979656 CACATCATTACTGAAA[C/T]GGTTGTAGAATGTTCC rs4771911 CGCAGAGATCACAAAAIC/TJGTGTCCCGCAGAAGGG rs905559 CACATTTTAAGGTCAA[A/T]TCGTCCCTTCAATGCC rs2738128 CACCACACCACACAGT[G/T]AAGGAATTGGTTCTGC rs9296512 CACCCCTAACCACATA[C/G]TAGAGTTAGACAGGTC rs5994440 CACCTATTTGTCTCTA[A/T]ATGTGGTCTTTCAGTC rs809213 CACGAGACGACTTCAG[A/G]AAGTAAGTAGGGAAAG rs7660550 CACGGCCCCCCGATGC[A/G]AACATTGCCAGGCCCT rs7088096 CACTTCTCCACAGTTA[G/T]GCCCAAAACAGATTCC rs4734805 CAGAGCAGACAGCTCC[A/G]GAGAAGAGGAACTCAA rs470455 CAGATGGTCACTTCAT[C/T]AGCATAAACACTAAGC rs6600814 CAGCAATTGAATTGCC[A/C]CCAA I I I I I ACAACAA rs535056 CAGCCTCTCTGCCTCAtC/TJTCCTCATAACTACTCC rs756625 CAGCTAAAATAGGAGA[C/T]AAGGGGCTGTGGACTC rs4755461 CAGCTGTGTTATTCTA[C/T]GCATGTAAGTCCCTAT rs2858638 CAGGAACAGTTATCAA[C/T]TCATCCCTGTCTCCTC rs765 CAGGAACTGCCTTTTA[C/T]GTCTGCAAATAAACTC rs7765427 CAGGATATTGGACACA[A/T]CTGAAGAGTAAATTCA rs9333202 CAGGGCAGTCCTGCTT[C/G]AAATCTTAGCATAAAT rs6570893 CAGTCAG AAG AGCTAG [A/T]CAAACAL I I I L I I AGA rs4147477 CATATGTAGGACAGAAfA/GJGGCTGTATCATGAGAT rs751082 CATCAACTCACCAGGA[G/T]AGTGAGCACTAAGAAC rs6539663 CATCAATTATGAAAAC[A/G]ATTACAACATCAGGAA rs6869049 CATCAGAGGTCTCAAAIC/TJGGACCGCCTGCAGACC rs4592597 CATCTAGTTCTTCACA[C/T]GCCAAATGAGCAGCTG rs8097577 CATCTCTGTACCTATC[A/G]CTCTTTAATGGAAAGC rs7653116 CATCTTCCAACATTTA[G/T]AAGGTTCACCTTGATG

rs4942969 CATGAAATTTTGCTTC[A/G]CTGTCTCCACTTTCAG rs9485946 CATGATTGAATAAATC[AZG]CTGGCCATTACTGACT rs639407 CATGCAATGGCAATAA[C/T]GTGTGGTGAGAACTCA rs4664386 CATG CTTTC ACTCTAG [A/G] AACTTTGATCCAGTGT rs4972535 CATTTTATAGGTAAGG [A/G]CCACAAGTCTCAG AAG rs791743 CCAACCTATCCCCACA[A/G]GTGAGTAATTAGTGCT rs7171902 CCAAGAGCACATCTGC[A/C]AGAAGTCATGTCAATG rs7175099 CCACCAAGGTAACTGC[A/G]ATACATTCATTAAAGG rs6691444 CCACCTTTTCTTTCAC[A/T]GATATCATGAAGTAGG rs7630377 CCACTCTATGTG CTCA [A/G ]CCTTCTGTTTTTACAC rs9525514 CCAGAGATGATTAGTA[C/G]AAGGCTGAGTAGGTGG rs9861931 CCATCAGCCTTATCAA[CZG]TGAGATCCATAAGTGA rs7628779 CCATGCCCGACAATCA[G/T]ACACTTTTACATCACC rs6940337 CCATTCTCATCTTATT[C/G]AAATTACTGGCACATG rs7342638 CCCAAAGTGGCTGAAA[C/G]ACAGAGAGCCAATAGG rs4682516 CCCAACAAATCTGTAA[AZG]CACCCTAGAAGTATGA rs831663 CCCAACTTGGAGATAA[A/C]CATTGTTAAATATGAA rs9276440 CCCAGATCATATTTCA[A/T]GTCCAGTAACACAGGA rs7067701 CCCCAAAGACAACCTA[C/G]ATGAGTGAAGAGCCAA rs7505697 CCCCTCACAACTCCAC[AZG]AAGAACGTAGTCCAGG rs6491586 CCCGTCCTTGAGATCG[A/G]ACCTGTCTTTGGGGAT rs9857723 CCCTACTCACGTCACC[A/T]ATAAAGACATACATTG rs6731529 CCCTTCATTGCTTATC[A/G]AAACCTTTTAGGTAAT rs7913948 CCGCCCAGGAGCGCGC[A/G]AAACCTTCTCCACACC rs5754909 CCGTTTACTGTGTTGA[C/T]AGATTTTGTTTTTGGT rs9791179 CCTACGCCTCTCCAAA[G/T]TTAAGG AAAATGTG AC rs4945729 CCTAG AG ACG ACTG AG [A/T] AACCTAAAG AAG AAAC rs6055035 CCTAGTGGCTGATAGA[A/T]GATTTAGCCCTATAAT rs7947110 CCTATAGGAAACACCA[A/G]TAGTGACCTACACAGC rs6439200 CCTCATC AGTG GTGAG [C/T]CCATCAACCTTGG ATT rs9908767 CCTGCCACAGGAGCCA[C/T]AGCAGTACCTACCCTA rs7732575 CCTGGGAAAGTATTGA[C/T]GGCTTTCATGAGGAAG rs3794970 CCTGGTGGGAACTCTC[C/T]CCTCTTCGCCAAGTCG rs454266 CCTGTGTCAATATATA[A/G]CTTTCTCTTTATGCAT rs5749237 CCTGTTCTGGATCCCA[C/T]TCCATCTTACTTCTTA rs6738614 CCTGTTGCCTTTCAGA[A/C]GGAGTTAATGGATAGC rs4973924 CCTGTTTCCTTACAGA[C/T]CTTTCTGGCAGCACTT rs6483813 CG CATTAAAGTACATC[A/C] CCTTAACTC ACTTCTG rs7655700 CGCCTAGGACAGACCTlG/TlAAATTTATAGACCTGT rs4498679 CGTGGGTATAACCGGA[CZT]GAAACCTGTGTGTGCA rs6488711 CTAAATATTAAGCAAG[CZT]AGTAGAAGCAAGGAAT rs473027 CTAACATTTTGTCCTA[AZG]ATCTTCCTGAACCTGG rs633095 CTACATCATCCACATA[AZG]TATCAGTAAAAATGAT rs7121300 CTACTGAAGTCTTTGA[AZG]TAATTACGTATCAGGA rs7904011 CTAGTAAATACAAAAA[GZT]GACCTAATGCTTAACA rs7786701 CTAGTCGGCTTTTTCA[CZT]GATTGCAAATCTGAAG

rs7215208 CTATCTCAATTCTTCC[C/T] ACGTTTGTTATGCATA rs6500336 CTATGATTTCTAGCCA[G/T]CTAGGGACTTCAGAAT rs7654444 CTATTTTCAGCACATA[A/G]GAAGTATCCTGTCTTT rs6065504 CTCAGCTCTTACAGAA[A/T]TACATAACAGTGCTTG rs9354486 CTCATACCAGATCTTA[G/T]GTAAAAGGATTTGAGT rs2971772 CTCATTCTTGGCAAAG[G/T]CTTCL I I I L I I GGTGC rs9947403 CTCCACATAAGTTTAAIC/TICTCAAATCAGCTTTGT rs4658437 CTCCTCTTATACCACA[A/G]TAATGACCAGGCACAC rs4810081 CTCCTL I I I I I AACCT[A/G]AACTTCATTGCCTGAT rs4857989 CTCCTTTCATGTGTG A[C/T] G ACTTCTCTCACTTCT rs6909578 CTCTCACCTTATAAAG[A/G] AGCG ACAG AAAG AATG rs7896663 CTCTCTTCTCCCTATC[A/G]ACCTTCTTCTCAGCCA rs9891554 CTCTGCCTCTCAGAGA[C/T]AGTGATGGCAGAGACA rs9394508 CTCTTGAGAGTGAAGA[A/C]CAGTTCTTTTCAAATC rs4235842 CTGAACAAAAGTGGAC[A/G]GCAATAATTAGATTCT rs284688 CTGAACCTCCTGAAAC[A/G]GAGAGCTGAAACAGAG rs7317235 CTGAAGTCCTTGCTGC[C/T]AGTTCAAACTTGTTCA rs853360 CTGAGGGCTTTGAGCC[A/G]GAACCTGCAACCAACA rs9360456 CTGAGGGTCAGTTAGClA/GlGAATAGTTCTTTCTCA rs4710333 CTGAGTATCTAACCAT[A/G]AAACTAGAGGTGGAGT rs6963627 CTGCCATGAGTTATGA[C/T]TAACCGAGAAAAATGT rs338668 CTGCCCAAAGAAGTGA[C/T]GATGTGAGATGATTAT rs7691385 CTGCTAATTCCTTAAG [A/G] CTC AACTCTG AC ATCA rs9846098 CTGL I I I I I I I CGACA[A/G]CTAAATAGTACTCCAT rs7691765 CTGTCATCTGGACTCC[A/G]CAAATAATATTCTAGT rs6105279 CTGTCTTTTGTACACA[C/T]AGCTTTATGACTGCCA rs5026429 CTGTGCTCAGCTTCAG[A/T]ATCAGCCCAGGGAGAT rs7071359 CTTAATTATGTCGAGG[C/T]CCAACAACACATGGTA rs7859190 CTTAA ^" nTTCAATATC[A/G]ACTTGACTGAATTAAG rs7162070 CTTACCAACAGCAGAA[C/G]TTAGCAGGGGGAGGCT rs3809485 CTTAGCTCTTTGCTTA[C/T]GGTGTTGCCAAATTCC rs609856 CTTAGTTTCTGG ATAG [C/TJCCATG ATATAGCAGTC rs7628402 CTTATGAAGTTCAAAA[A/G]TGAGTAAAACTAACAC rs6744496 CTTATTGGTCTTGACA[A/G]ATTCTGATGTGATTAC rs2713249 CTTATTTTGCTTAATA[C/T]GTCAAGGTTCATCCAT rs7135085 CTTCACGCCTTGCACA[C/T]TGGAAAACTGTCATGA rs7919239 CTTCTGATTTCCCCGA[G/T]TCCTAATGAAGTTGAA rs7606793 CTTGAAGAAGATAAAA[A/G]GGCAAACCACAAGCCA rs4678297 CTTGCTCCCTATGTCA[C/T]TACTCCTCACCCTTCC rs3181227 CTTGGAACTGTCTCCA[C/T]GAGTCATAACCATACT rs924507 CTTGTTCTGCTCACAA[A/C]AAATCATCTTTCCTTG rs6787455 CTTTCATAGTCAGACA[A/G]GGCTCTGTTCCAGGGA rs3824613 CTTTGTGCGAGCGCAG[A/G]CATCCCCATTCCATGC rs9362923 CTTTGTTCTCTGATGC[A/G]AAAAATCTTCAGAAAC rs9563077 CTTTTTCCTGCTAAGA[A/C]GGCACTGTTGGAAGGA rs6767907 GAAAACAAATAGATAA[C/T]CGCCTGCCTGAACTTT

rs7029315 GAAAATATTTGAGGAηA/GlAATGTCTAAATGCAAG rs6967329 GAAACCATTGTATCAG[A/G]AACTGAAAGGAGATCA rs272531 GAAAGTAGGGAAACTCtA/GJATCTTAGTTTATAATT rs9807929 GAAATGTGCCAGTAGAfA/GJCTTTATGGGTGAAAAA rs7126809 G AACACTAAG ATTATG [A/GlAAGTTAGAACAACGCT rs3844177 GAAGAGCAAATGCAAA[C/G]ACCAAGAGTTGGGCAC rs9877228 GAAGAGGCTTCTGTTC[C/G]AAGATTGGAGATGCTA rs7047415 GAAGCAACTTAGTTTC[C/T]CAATGAAAGCTGTAAC rs273770 GAATGAAACTAGAAATtG/TjAATGGCAGACAGAAAA rs9643109 GAATGAACTCAAAATAfC/G] ATTGTGG ACTTATATG rs909565 GAATTGCATGCCAGGA[C/T]AGTGTTGATGAACCAA rs4995246 GACAAGGGAAAGTTCC[A/C]AGAAGAGTGATACCTC rs2699749 G ACACTAG ACATTGGG [A/T] ATG AACAGACATCAGG rs2710850 GACATCTGAAAGGCGA[C/T]GTTGCTGCCTCCCCAG rs7951911 GACATGCGTGACTGTC[A/G]AGCAATAACCATCACT rs6720902 GACCACGGGCTTTGAG[G/T]AAACATTGGCAGTAGC rs7607204 GACCCCTTTGGTGAGA[C/G]AATGGTCTTGAAAGTA rs3781749 GACGGCAGACTACATA[A/C]CCTGAAGGACTTCACC rs7169478 GTGAGCATTCAGACTC[A/G]ATAGTGCTGTTCTGTA rs8029602 TGCAACTAAGAGGAGA[A/G]CCAATGGAGCAACACT rs7677908 GACTGATTTCTCTTGC[C/T]AATCATTAATATCCAA rs6065603 GACTGCCTGCACCCAA[C/G]TCCTTATCTCTCAATC rs3914604 GAGAACATTTAGCTCA[A/G]GTCTAATAGCAGTTAT rs6592344 GAGACCATAAAGTCTA[C/T]AGGTTGGAGTGTTGTT rs4756347 GAGACCCTTAGTGGAA[A/G]GAAGACTTGCCAAAGT rs7257383 GAGAGTGGATAGAAGC[A/G]CTAGGCTGTGGCTTTC rs557292 GAGATTCTGTATTTAA[C/T]GAAAACTGCCGAGAGC rs7983524 GAGCAGAACTATTAAA[C/T]AACAAGGTCTATATGG rs7912740 GAGCATAGGCTGAGGA[A/G]AAGGAACCAGCCCCAC rs4775711 CCTCCTGTTGTAGCTA[C/T]GGACTACCTTAAGGAG rs6489601 GAGGAAAAAAACGGTA[C/T]GTATGCGTATTCAGAT rs3123669 GAGGATACAGCAAGAA[C/G]GTGTTTGTCTACAAGC rs7751204 GAGGGCTGGCATTCAA[A/C]GAC I I C I I CGAGTGTT rs290253 GAGGGTAGAGTTTAAAlA/ηCATTGTGATACAAATG rs7170930 GAGGTAGAGAAGGACC[A/G]AAGTGATTACCCAGGC rs4963959 GAGTAAAAGACCCAGA[A/G]GAGAGTTTGGTGCCTA rs831969 G AGTGATCCTTGCCAT[A/G] ATAGAATGTTCTGGTT rs9317560 GATAAATGACTCGTGAIC/TIATTAATCTGAAGTAAA rs4859547 GATGCTAATGTAACCA[C/T]GCATAATGCTTGCTTC rs3781500 GATGGAGCATGAAGACtG/TlGAGAAGAGAGTTAAGG rs9888595 GATGπCTπAGCAAA[C/T]GAGGAAOTCACCTCT rs4461205 GATTACCCTCACACTC[C/T]CCTTGTTAAAAGCTCC rs8081285 GATTCACAATCTACAAIC/GJACCAGCCCAGCCTATC rs9911421 GATTGGTGTTTGACTG[A/C]ATAGCTGGGAATTCTA rs7314308 G ATTTCC AATTACC AG [A/G] CAATATGTTATGTG CT rs6427673 GCAAATGCTTCACAAC[A/T]GTTGTCCTTGGTCTAA

rs9966194 GCAAGTGAAAGTGAAA[C/T]AGCTGTAATG/WVTTA rs34266279 GCAGCATGCGGTCCAA[A/C]GTAATAAACAGATGTC rs6081676 GCAGGGATTTCATGTA[C/T]GTGATGAGAGACTCCT rs4810777 GCAGTACCAGCAAGAC[AZG]ACCAAGAAGAGGCAGT rs7828061 GCATCAGTCCATGGAG[A/C]AATTCATGCCCCAGAT rs4710884 GCATTACTACAACCAC[A/G]CTTAAAGCACGGTGTA rs3917768 GCCAAAATTTGGGCGC[A/C]GATTCCACCACTTGGT rs9506133 GCCACGTTAAAATTCC[A/G]CACTCAGCCAAGCAAC rs6038846 GCCACTTGTTGGTTGA[A/G]CATGCTTCTGAAGTCA rs7952511 GCCATAGCTGTTGTAA[C/T]GTTGCCATGGTGCAAC rs682970 GCCATCTCATCTCATG[A/G]AGACGCAAAATGGTGT rs5753560 GCCCAGGGTGCCTTAA[C/G]TCTGCCTGTCCCTTCT rs9557510 GCCCTTTGGTATCACA[A/G]AAAACCTCTAAGCCCT rs7117485 GCCGATTGCCATATAT[C/G]ATACAAAGCGGGCTTG rs7111704 GCCTATCTATCTAACA[A/C]CTCTGACAACAGAAGA rs4314444 GCCTTGTGCTAGTAAG[A/T]ACTTATTGAGTGAATG rs3793561 GCGATTGTTGAAATCA[G/T]ATCTACTGAAACTCAT rs4916446 GCTAGATCTCTCTCCA[A/G]TGCTTTACTCTGAGCA rs4881336 GCTGCAAGTGGCTTAA[C/T]GATATGTTCCTGGAAG rs7310117 GCTGCGATGCCAACCA[A/T]AAACCCCTCCACAGTA rs2956830 GCTGG ATGCATTAACG [C/T] AAAGTG AATATACCTG rs4842243 GCTTCCAAAAGTAGGA[C/T]GGTGCCTGGAGCGACC rs4812276 GCTTGTTTAGTTATCA[A/C]TCCTCCCAAACACAAT rs7525955 GGAAAAGAAGTTACTAtC/^AGTTTTGCATAGAAAG rs4750774 GGAAAGTTCAGTATCGIC/GJATTAATAAAGAGAAAC rs8031930 GGACTGGGTAGTGACA[C/G]AGGACACATGGGGGCA rs4691170 GGAGCAGTTTTCTACA[C/T]TGAAGAACATCCAACA rs4842244 GGAGCGACCAGGGTAC[C/T]GACACCATCTTCTCGA rs9357738 GGAGCTGCGACTAGAA[C/G]GTGGTCGGATAATGCC rs8094838 GGAGCTGCTAAAGTCA[A/G]ATAGGTGGGAAACACA rs6736615 GGGAAAGCAGTAGTAA[C/T]GTCTCATAGATGTGCC rs4821241 GGTAGTTTGCTGGCTA[A/G]GAGCAATAAAGGTGAC rs7577717 GTGGAAATATTTGAAAlA/GlCATTATCCAAGTACAT rs3846498 GTTCTCTTTTGTGCAA[A/C]ATTCCCAAATCTGATT rs7779004 TAAAACAATTCAATAG [A/T] AC AG C AAAC ATTAAAA rs9519469 TAAAG AAG ATCG ACATIA/GJAATTATTCCATAAAAT rs811811 TAACAGTATATAAAGGfC/TjAAGGTCTGGAATTAGA rs6914118 TAACCACACAAACAAA[C/T]GTGACATTATTACATG rs9436540 TAATCATGGCCTCTGC[A/G]ATATTCTGAACTCCTA rs8089366 TACCTAAATGAGACAA[A/C]TGAAACGCATATACAT rs7801566 TACCTAACAGGCTATGIA/GJACCAGAACTGGGCCAC rs321974 TAGCCTCAGGGCACAG[A/G]CTGAACCAAAAAACAG rs6821995 TAGTCTATAAAATCTA[A/G]CATAGTGCTTTGCATG rs4445563 TATAAACTAGGTGAGA[A/G]TCCAGCTGCTGAGTGA rs935466 TCCACCACTGCTACCA[C/T]CAAGAGATCAAACCCA rs4736185 TGGGGCACAGATACAC[C/T]GAGTAACTTGTCCAAG

rs7239405 ACTGTTCTGAGGTTCC[C/T]ACTAAATACATTTGTT rs6449750 TTATACCATTCTAGAC[A/G]CTAGTCCTTTGTCAGA rs6676401 TTCTCTGCCTATGTCC[C/T]AATTTAAAACCTACAC rs903808 TTGAGATGGGATGAGAtC/ηAGGAGTTAGTAGAAAC rs897983 TTTATCCCAATGAGTA[C/G]AGTGGAGAGTATTTAA rs2927035 TTTATCTTCTCCCCAA[C/T]CTCAAACTCATAAAAT rs6703571 TTTTAAGGTCTTTCGC[C/T]GATTGAATCAGACCCA rs9287822 TCTTACTCTCATGGAC[G/T]CTAAAGCAAAATCCAC rs6047186 AATGAATGAGAAATACIA/GJAAACCAGAATATGAGG rs2837017 ACCTTCCCTGTATGAA[C/T]GACTCCTCAGAGTAAC rs939298 TCTAAAATAGAAAGAA[C/T]GCAAAGCCTTAGAGAG rs658232 CCCTGL I I I C I I I CTA[C/T]GCCCTGAAGATGAAAC rs9328513 TTAAGAGCCATGAATA[A/G]GTATCTCATTACCTTT rs3846820 CAAAATTCTAAAATAT[A/T]AGAGTGCAGTTGTCAT rs2926095 AGTGTACTGCTGATGA[C/T]GAGAAGGAACTAAGGA rs4130030 TTTTCTATGGTTTGAA[CZG]TCTTGGTAATTACCTC rs4634696 TACTGCTTCTCATAAC[C/T]GTGTGCATGAGGTGAT rs7244113 AGCAGGTCAGTATCTG[A/T]CAAAATTCTCAAGGAA rs7421353 TCTGTGCTCTCAATAA[C/T]CCTATATTCTTGTGCG rs6720074 AGAAGATAACTGCATA[A/T]AGAGAGAGAACTCTGG rs3857156 TTGTCTTGTATTAGTG [A/GJAGGCTGCAATCAGTGA rs2841573 GCTAGAACCTTCAAAC[A/G]AGCTTTCAAAATAATG rs2831941 ACTGTG CTTGTTCCAC[A/G] CTTG CCTACAGTG GTT rs845022 TGGGAATGTAAAAGGGlA/TJAGGCACTCCGGAAGAG rs844986 AATCACTCGAATTAAA[C/T]GAATCTCTTCTATACA rs2836535 TTGAGTGTTGGAACCA[C/T]CTTTGTACTTATCCAT rs7484891 TCATTCTCTTTAAATA[C/G]TACTGGTTTGGAAGCT rs6547260 AACAGAAAATTAAGAT[A/C]AGATTGGCTAACAAGA rs6588759 AAGGTCAGCACTGTCA[C/T]GTAAGGTATGTGCTGA rs6414256 AATCAGTGTAGTAATG [C/T] ATG ATG AAAATAACAT rs619192 AATGGCCTTTATTACA[C/T]AGAGAAGCTTTCCTTC rs3852203 AATTATTTTGGCAGGC[C/T]ATTTTGCACAGATAAT rs7975586 GACAATACATTAGGTA[C/T]ATTTTCACACCTTACT rs973328 AGTGCATTTGCAAATC[C/G]TTGGTTCACAATAAGT rs9548386 ACTCTGTACAAACACA[A/G]TL I I I I I IAATATCAA rs6072819 ACTTAAATGCACCAAC[A/G]ATTGGAGAGTAGTTAA rs9954459 AGAAAAGGAGTTTATAfC/TlGTAGTGTAATTATTTC rs2964003 AGAGACTTCATCATCA[C/T]GCTCTGCTGTCTGCAC rs4775656 AGAGCAGCAGACCAAC[A/C]AGATATGTTTTTAATG rs6692131 AGCCTTCCCAAAAGAC[A/G]AGACCTGTGCACTATG rs8017215 AGGAAGATGGACAAGA[A/G]TCTCACTGCTGAGAAT rs9364250 AGG ACCTCTAGGTTAG [C/T] AG AGCATAAAGTTGG A rs7213403 AGGGGGGAAATGATGAIC/TJGAAATGTAACGTGGGA rs4869544 ATCGTTCCAGTCTTAG [C/T] ATATGTGCTGCCAAAG rs4310272 ATGTTTTAGGACCTGAIA/TJAAGTGTATTATATTTA rs3867196 ATTCTGTTAGGACACA[G/T]CAAGTTTTATTAAATT

rs4677360 CAATTCCGGCACTTTC[C/T]AAGAAGCCAAGAATTT rs4955377 CAGGCAGGAAGTGCTA[A/G]GGGAGAACACACCCTG rs9634125 CCAAACTTGCAACTCA[C/T]ATCTGAAATTGGAAGG rs4888881 CCAGCCCTCTGTCTCA[C/T]AGAAACTCTTAACTCA rs6438104 CCTAAATGGGTCCTAC[A/G]CGTGCCCTGTTAAATA rs478907 CCTAGGAGAGGGTTGAIA/TJGATGGTTAAAGAATAC rs2858124 CGAGCTTGGTTTAGAC[C/T]CTCATTTTGTCTAAAC rs3766345 GGCAATACAACCTGAT[C/G]AGAATTTATCTACCTT rs6747506 CTGTGTGTTGCTGGGA[A/T]CAACATCCTTAGAGCG rs6663947 CTGTGTTTCTTTAAAA[G/T]ATTGACAGTAGTCAGG rs985288 CTTAGTGGTATCCACA[A/G]ATAATCTGGCCTGGGG rs7842637 CTTATCCTAAGTCTCA[C/T]GCTCCATACAAAAATT rs6428058 CTTCAL I I I I I CCCTG[A/T]ATATTGCTCTTCCCTT rs9342838 CTTGTATGGCACCTTA[C/G]AGCAACACATTGACAC rs947377 GAAGGAGCTGTACCAC[A/G]GACAAGAAGAAGATGG rs744564 GAAGGCGGCCTGAACC[G/T]AATGGCCAAAGAGGCC rs895696 G ACATTCAGTCCACGG[A/G] AACAAAG ACACGG ACT rs7764326 GATTTAAAAGATGACA[A/G]CACATTTCTTACTCTT rs468700 GCACTCCAATTGTGGA[A/T]TCATTAGAGAAAGAAT rs3853477 G CATTCTCG CTG CCAG [C/T] ATGGGAAGG ATTACTC rs4931081 GCCACAAGG ACTGCAA[C/T] ATCTAGGTG AGTCTTA rs7093688 GCCATAGTCAATGCTA[A/T]GTATAAAGTTAGCAAA rs996967 GGAATGCAGATTGTTAlA/ClAAATGAATCTGTGTTT rs4788933 GGCAGTAGAGCACTTA[A/G]GAGAGGGGACTCCAAA rs407929 GGCCTTTGAGAATTGC[A/G]GAAGGAGCCCACTGGG rs896930 GGGTCAGCTCTGTGCA[G/T]CTCAGACTTCGTCTCC rs3759320 GGTGAAACTACTGGAT[A/G]AGAGAGATGAGAGGCC rs2897642 GTAAGTAG ^" πTATGAA[G/T]CCCTTTCTGATGATGA rs563697 GTACTGCTGCTCTCAT[C/T]ACTATCTTTTCCTCTA rs3820821 GTCAAGTCTG AACCTC [A/G] C ATTTTCTCCC ATCTG rs6903130 GTTTTGAAGATAGAGA[AZG]CAAAAGCTGTGAAGAA rs6946578 TAAATGAAATGTTGTA[C/T]GCATTGTTG I I I I I I A rs2714050 TACAGCAGGAGGGATT[A/T]AAGTCATCCTAGTTCC rs7304649 TACAGTTAGGTAAAGAIC/TJAGAGTGGTGAGGGTAA rs3764718 TAGAGAGGTCCTCCAC[G/T]CAGATACTTAAAGATT rs9345112 TAGGTCTATGAAGTTAIG/ηGTTTTCAGGAGGGCTA rs3766623 TATATTTAATAGTTAA[C/T]TCCATTTTTGCAGCTT rs9296043 TCTGTGAGAATAGAAAtA/GjTGAATCTTTTGGGAAG rs7903259 TGCTTAATATACTTCA[C/G]ATGTCTGCAAGGGGAA rs592228 TGTATAAACAGGTGAAIC/TJGAAATGTGACATATAC rs3099848 TGTGGG AG ATGATAAG [A/T]ATTTGTTGTTTTGGGT rs3101088 TGTTCCATTAAGTCAC[C/T]GTAATTTCTTACCTGA rs2895647 TTACCGTCTAGAAGAC[C/T]GACAAACAACCCCTGC rs8089273 ACTTACTTGCTAGAAA[A/G]TATGGGACAGGGTCAG rs3846087 TTACTTGGATTGCAGA[C/T]GGCTTTTTCTCTGGGC rs6567316 TTAGAATGCAAGTTAGIA/GJACCAACATGATTAAAA

rs4442964 TTCCTTTGCCACAGAA[A/G]TGAGACATTTACAGCA rs7681711 TTGTTTACCCCATATC[A/G]ATTCACCCTTCCTTCC rs35406 TTTATTAGTTAGCACT[C/T]AGAATGAGTTCATTTT rs6489602 TTTTGTGCCACATTCA[A/G]TCCCTGCAAAGGCTCT rs464357 GGTCAGGGACTAAGGA[C/G]AGTACACCCAGTCCTA rs2829267 TACGTAGAAGGCTGTC[C/T]L I I I I I ATCATTTATT rs931567 AATAAAGTCTCCAAGA[C/T]AGCTTTGTGGATAAGA rs513994 ATTAGGCCCAGATTTA[C/G]AGTGAAATGGCATGCT rs7653303 GCAGTAAAGTGCAAAA[C/G]TCAGTGCTGTTGGCTC rs4463024 GAGTAAAAATACACCA[A/G]TGATTCTTCTGTAGAC rs7453920 GCAGTCGGACCGATTC[A/G]ACATTGACCTCTGCTC rs9296318 GCTTTAG AAACCCAGT[A/G]AAATACATCAG AACCT rs726820 GATGGGCACAAAGACA[C/T]GGAGAATTCCAGGTGG rs4876153 GAACTTGCCAGGCTAA[A/G]AATGATATTAACATTA rs7004769 TCCAAATTATAACCCT[A/G]AGGCAGTGAAGATAAA rs9325744 ACATACATTTCTCATC[A/G]CGCTCAAGGGACTCTT rs7988493 GTAGGAAGGGTAAACC[A/G]AAAAGCGCAGGAGAGG rs30751 TTC I I I I I I I CTCATC [C/T] CAAGTCTTC AAACTCC rs2829290 TATTAACTTAAACACC[A/G]ATTTGCTCAAATTTCT rs4495966 AAAGAAACTGAATCTG[C/T]AGTTGAAAACCTTACT rs982926 AAATCTTAAATCCACA[A/G]GATGAATTACAGACTA rs667897 AACATCCGGTATGGTA[C/T]GACACAGCGGGTTTGG rs2814689 AAGGAACACTTACGCA[C/T]GGTTGATGGGAATGTA rs9530648 AAGGTCCAAGAACTGA[A/G]CTTTGGGACACTCCAA rs4661292 AATGTCTCTCAAAAGA[C/T]GGACTGGCTAGCTCAC rs6117825 AATTTTCCTAACTGAT[A/G]AGACTCTCCTTGAAGT rs7850197 ACCTGCCCCTTTCCCA[C/T]GTGCTGTAGGCTTTCC rs6510704 ACTCCTGCTGCTCCCA[A/G]GTGTAAAGAGTGACCC rs9354349 ACTTGGAACTATAGAA[A/G]TACTGCATTATTGCAA rs2811489 AGAAGTTGAACATAGGIA/GIATTAGGAGATTGTGCA rs2926110 AGACTCAAAAGACATGIA/GJATGATCCAAATATGAC rs6095323 AGAGCAGCTGGACAAC[C/T]CAAATCAACGCTGGAC rs2962792 AGGGAATTTAGGAAAC[A/T]ATAGGAAATCAACACT rs719199 TGCTACTGTGTTTTGC[C/G]CAGAGTTAGGACAATT rs4536931 ATACAACCAGCAAACA[C/G]CTAGATTGCAGCTACA rs9502593 ATACTTAA I I I I I CCA[A/G]TATGGTCTAGGTTAGA rs7452656 ATATCCTATAAGTTGA[A/C]GAAATATGTCAATGCT rs2791512 ATATGAGACTGGAAGA[C/T]AAGAGAGACTTCCCAC rs6998702 ATCAATACTTACCCTA[A/C]AGCTGCAGTAATTCAG rs9332950 ATCACCAATAACAGGG [C/G] AAACTG ATATCATATG rs4546534 ATGAGACATTTAGAAC[A/G]GTGCCTGTCACCTAGT rs4670110 ATTATGCCTGAGAATT[G/T]AATAAGGGTCTTAACA rs7987278 ATTCCTTCTGAATGCA[A/G]ACTGTTGATATCCTTC rs2683690 CAAAATCATG G CTCCA [C/T] CTCTGTG ATATTTTG A rs7559372 CAAAATGAAATAGAAA[A/C]AACAGAGTAGCCCAAA rs4810082 CAAGACAAAAGTCAAG[A/G]CACTCCTCTTTTTAAC

rs3020821 CAAGTTATACAGAGGC[CZT]CAAATGCACACCCAGT rs424339 CACACATATTCAGTTC[A/G]CTGTGAAATCCGTCCA rs988026 CAGAAATAAGCAGTTA[A/T]ACAGAGGAAAACTCAG rs4658439 CAGCTTACACTGGCCA[C/T]GTGGTATCTTGATGAA rs4879628 CAGGTACTGAACTCCC[A/G]GCTCCTCTACAGCCTG rs284689 CATCGGTTTGCAGAAC[C/T]GTGTCATGGAAACCAC rs7811948 CCAAATCTCGTGAGAA[A/G]TCCTCACTATCACGAG rs4769010 CCACACTTTGCTAATC[A/C]ATAGTCACCCAACCAG rs865094 CCCAATGTCTCATGGC[C/T]AGCAAGTATGAAACTC rs6966339 CCCAGCACCCATTTGA[A/G]GAGTTTGTGCTTCCCA rs9940288 CCCCCGCTGGGCAGCA[C/T]ATCTGTGTTTTGGCAA rs4946666 CCCTGTAGTATAGTCC[A/G]AAGTTGGGTACTGTGA rs4659401 CGCGCCCGGCCAAGACIA/GIAATCATTTCTACATGC rs7910407 CGGCAGGTCCGTCTGT[AZG]AAATGGAGGAGGTCTT rs6585304 CTAAGCTAACTGAAAA[AZG]ATTGGCATATCACAGG rs7714857 CTGAAAGATAACAAAA[G/T]GCGTGCTCATGGGAAA rs490767 CTGTTTG ACTTCAAGG [C/T]CAGG ATCCCGTTTTCC rs6129067 CTTCACCCACCAGGAA[AZC]AAATGGCACATTTACT rs6926642 CTTTACGGTAGCGAAA[A/G]TAGCTGACGCACATAT rs5749917 CTTTATGTATGCCAAA[C/T]ATTGTTCTCAGTGCTT rs6570889 GAATTCATTAAGATACIA/GIGTAAGGTCATAAGAGT rs7692314 GAGCGAGGAAGGCAGA[CZT]GAGAGGATCTTTCCAG rs7624432 GAGCTGGAAATAAAGA[AZG]CAATCATTTGAATCAA rs6004408 GAGGAAGCCTGATACA[AZG]GACTTGGATTCGCCAT rs7677150 GAGTCCAGAAATAGTG[AZG]AAACCCAGATAACAGG rs4238998 GATAGTACCAACTTCA[AZT]GAGGATTGCTGTGCTC rs942989 GATCAGATTTACTTAA[AZG]GCTCCATCATCACACA rs9276490 GCATACACATTCTTTA[CZT]AGTTGCATTCCTGAGA rs6069858 GCTGGAAGAATTCAGA[AZG]GAAGATGCTAGAAAAG rs869346 GCTTTGGTGGGAAATA[CZT]GATCAGGACTGAGACC

Table 3

Gene symbol Gene Name

LOC100134599 hypothetical protein LOC100134599 LOC100134405 similar to hCG2020224 LOC100134384 similar to coiled-coil domain containing 63 LOC100134077 similar to adenylyl cyclase LOC100133966 similar to hCG1783650 LOC100133876 hypothetical protein LOC100133876 LOC100133607 hypothetical protein LOC100133607 LOC100133292 hypothetical protein LOC100133292 LOC100132013 hypothetical protein LOC100132013 LOC100131863 hypothetical protein LOC100131863 LOC100131677 hypothetical protein LOC100131677 LOC100131632 similar to dipeptidyl-peptidase 6 LOC100131270 hypothetical LOC100131270 LOC100130999 hypothetical protein LOC100130999 LOC100130882 hypothetical protein LOC 100130882 LOC 100130460 hypothetical protein LOC 100130460 LOC100129848 hypothetical protein LOC100129848 LOC100129701 hypothetical protein LOC100129701 LOC100129518 similar to hCG2029803 LOC100129342 hypothetical protein LOC100129342 LOC100129150 LP5624 LOC100129101 hypothetical protein LOC100129101 LOC100128876 hypothetical protein LOC 100128876 LOC100128648 hypothetical protein LOC100128648 LOC 100128641 similar to hCG1641533 LOC100128612 hypothetical protein LOC100128612 LOC100128283 similar to hCG1775427 LOC100128040 hypothetical protein LOC100128040 LOC100127946 hypothetical protein LOC100127946 RELL1 RELT-like 1

hCG_1745121 similar to notchi -induced protein

DIRC3 disrupted in renal carcinoma 3

LOC729578 hypothetical LOC729578

LOC729436 hypothetical LOC729436

LOC729239 hypothetical LOC729239

LOC729065 hypothetical LOC729065

LOC728755 hypothetical LOC728755

LOC728528 hypothetical LOC728528

LOC728360 hypothetical LOC728360

LOC728174 hypothetical LOC728174

LOC727995 hypothetical LOC727995

EGFL10 eyes shut homolog (Drosophila)

LOC653794 hypothetical LOC653794

LOC646951 similar to cg14142-pa

LOC644993 hypothetical protein Ioc644993

MS4A4E membrane-spanning 4-domains, subfamily a, member 4

LOC643339 hypothetical protein Ioc643339

FLJ43080 hypothetical protein Ioc642986

LOC642340 hypothetical protein Ioc642340

RNF165 chromosome 18 open reading frame 23

PALM2-AKAP2 PALM2-AKAP2 readthrough transcript

LOC441239 hypothetical gene supported by bcO63653

C5orf40 mgc27121 gene

SAMD12 sterile alpha motif domain containing 12

LOC392288 similar to microtubule-associated proteins 1 a/1 b light chain 3

LOC390637 similar to riken cdna d330012f22 gene

LOC390282 similar to eukaryotic translation initiation factor 3, subunit 5 (epsilon)

GFRAL ivfi9356

TNFAIP8L3 tumor necrosis factor, alpha-induced protein 8-like 3

ANKDD1A ankyrin repeat and death domain containing 1a

PLCXD3 phosphatidylinositol-specific phospholipase c, x domain containing 3

VSTM2B hypothetical Ioc342865

TMPRSS11A transmembrane protease, serine 11a

ZNF181 zinc finger protein 181 (hhz181)

C17orf67 chromosome 17 open reading frame 67

ST8SIA6 stδ alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 6

KCNK18 potassium channel, subfamily k, member 18

NSMCE2 chromosome 8 open reading frame 36

SFRS12IP1 p18srp protein

RNF180 ring finger protein 180

WDR62 chromosome 19 open reading frame 14

LOC283867 hypothetical protein Ioc283867

GPR133 g protein-coupled receptor 133

C12orf64 hypothetical protein flj90579

SGMS1 transmembrane protein 23

FRMD3 ferm domain containing 3

MAMDC2 mam domain containing 2

ZBTB38 hypothetical protein flj22332

FAM83B chromosome 6 open reading frame 143

SLC35F1 solute carrier family 35, member f1

SDK1 sidekick homolog 1 (chicken)

JAZF 1 juxtaposed with another zinc finger gene 1

PHACTR 1 kiaa1733 protein

SPATA13 spermatogenesis associated 13

RNF152 ring finger protein 152

D0K6 docking protein 6

SENP5 sumoi/sentrin specific peptidase 5

KHDRBS2 kh domain containing, rna binding, signal transduction associated 2

TMEM16F transmembrane protein 16f

SNX31 sorting nexin 31

COL22A1 collagen, type xxii, alpha 1

FSIP1 fibrous sheath interacting protein 1

GPR180 intimal thickness-related receptor

CCDC63 coiled-coil domain containing 63

LING02 leucine rich repeat neuronal 6c

RLBP1 L1 hypothetical protein mgc34646

NKAIN2 t-cell lymphoma breakpoint associated target 1

PNLDC1 poly(a)-specific ribonuclease (parn)-like domain containing 1

MB0AT1 o-acyltransferase (membrane bound) domain containing 1

PLAC8L1 placδ-like 1

CNTN4 contactin 4

C3orf59 chromosome 3 open reading frame 59

ZNF385B zinc finger protein 533

LCA5L Leber congenital amaurosis 5-like

EME1 essential meiotic endonuclease 1 homolog 1 (s. pombe)

FAM81A family with sequence similarity 81 , member a

MIP0L1 mirror-image Polydactyly 1

TSPAN 19 tetraspanin 19

SYT9 synaptotagmin ix

TRUB1 trub pseudouridine (psi) synthase homolog 1 (e. coli)

ADAMTS14 adam metallopeptidase with thrombospondin type 1 motif, 14

MACR0D2 chromosome 20 open reading frame 133

L0C137886 hypothetical protein loci 37886

VO

SGCZ sarcoglycan zeta

ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6

SYNPR synaptoporin

KCNH8 potassium voltage-gated channel, subfamily h (eag-related), member 8

KCTD 18 potassium channel tetramerisation domain containing 18

TSHZ2 chromosome 20 open reading frame 17

UHMK1 u2af homology motif (uhm) kinase 1

ZNF813 flj16542 protein

CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20

MSI2 musashi homolog 2 (drosophila)

C14orf148 chromosome 14 open reading frame 148

F0XN4 forkhead box n4

CPXM2 carboxypeptidase x (m14 family), member 2

MAS1 L mas1 oncogene-like

ZNF554 zinc finger protein 554

0SBPL1A oxysterol-binding protein-related protein 1

CCDC85A kiaai 912 protein

BTBD9 btb (poz) domain containing 9

NLRP3 chromosome 1 open reading frame 7

PALM2 paralemmin 2

GLCCI1 islet cell autoantigen 1 , 69kda

PHF21 B phd finger protein 21b

TMEM183A chromosome 1 open reading frame 37

DTD1 histidyl-tma synthetase 2

TMEM132C transmembrane protein 132c

STARD 13 start domain containing 13

KCNH7 potassium voltage-gated channel, subfamily h (eag-related), member 7

GLB1 L2 galactosidase, beta 1 -like 2

SLAMF9 slam family member 9

LL22NC03-75B3.6 kiaa1644 protein

UBASH3B cbl-interacting protein sts-1

PLXDC2 plexin domain containing 2

RNASE7 ribonuclease, rnase a family, 7

O

COL25A1 collagen, type xxv, alpha 1

MAML2 mastermind-like 2 (drosophila)

TMEM117 transmembrane protein 117

NLRC5 nucleotide-binding oligomerization domains 27

LRRIQ1 leuciπe-rich repeats and iq motif containing 1

CTTNBP2 cortactin binding protein 2

PITPNM3 pitpnm family member 3

ST6GALNAC5 st6 (alpha-n-acetyl-neuraminyl-2,3-beta-galactosyl-1 ,3)-n-acetylgalactosaminide alpha-2,6-sialyltransferase 5

ADAMTS12 adam metallopeptidase with thrombospondin type 1 motif, 12

D0CK8 dedicator of cytokinesis 8

KCNIP4 kv channel interacting protein 4

CEP63 centrosomal protein 63kda

ALPK1 kiaa1527 protein

FRAS1 kiaa1500 protein

TRPM3 transient receptor potential cation channel, subfamily m, member 3

SEMA6D kiaa1479 protein

PCNXL2 pecanex-like 2 (drosophila)

GRHL2 grainyhead-like 2 (drosophila)

SCD5 stearoyl-coa desaturase 5

C20orf39 chromosome 20 open reading frame 39

ATP8B4 atpase, class i, type 8b, member 4

CATSPERB chromosome 14 open reading frame 161

ZNF385D zinc finger protein 659

BCL2L14 bcl2-like 14 (apoptosis facilitator)

FTO fatso

PCDH15 protocadherin 15

TMEM135 hypothetical protein flj22104

SLC30A5 solute carrier family 30 (zinc transporter), member 5

EFCAB6 cap-binding protein complex interacting protein 1

DDX31 dead (asp-glu-ala-asp) box polypeptide 31

CCDC136 hypothetical protein dkfzp434g156

CSMD1 cub and sushi multiple domains 1

CENTD3 centaurin, delta 3

CHST8 carbohydrate (n-acetylgalactosamine 4-0) sulfotransferase 8

RFWD2 ring finger and wd repeat domain 2

RAB 17 rab17, member ras oncogene family

CLSTN2 calsyntenin 2

LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase

NPAS3 neuronal pas domain protein 3

PERP perp, tp53 apoptosis effector

KIF13A kinesin family member 13a

CCDC90A chromosome 6 open reading frame 79

SLC22A23 solute carrier family 22, member 23

SPCS3 signal peptidase complex subunit 3 homolog (s. cerevisiae)

HPSE2 heparanase 2

BACH2 btb and cnc homology 1 , basic leucine zipper transcription factor 2

WDR19 wd repeat domain 19

SLC7A14 solute carrier family 7 (cationic amino acid transporter, y+ system), member 14

CPNE5 copine v

CRAMP1 L crm, cramped-like (drosophila)

SORCS2 sortilin-related vps10 domain containing receptor 2

MTUS1 mitochondrial tumor suppressor 1

NDRG2 ndrg family member 2

SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3

SENP7 sumoi/sentrin specific peptidase 7

PCNP pest-containing nuclear protein

DDX24 dead (asp-glu-ala-asp) box polypeptide 24

ADAMTS9 adam metallopeptidase with thrombospondin type 1 motif, 9

ANKS1 B ankyrin repeat and sterile alpha motif domain containing 1 b

DPYSL5 dihydropyrimidinase-like 5

MDM 1 mitochondrial deafness modifier 1

EIF4ENIF1 eukaryotic translation initiation factor 4e nuclear import factor 1

SULF2 sulfatase 2

C1orf183 chromosome 1 open reading frame 183

THEM2 thioesterase superfamily member 2

EAF2 ell associated factor 2

ST6GALNAC1 stθ (alpha-n-acetyl-neuraminyl^.S-beta-galactosyM ,3)-n-acetylgalactosaminide alpha-2,6-sialyltransferase 1

CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta 3 subunit

C7orf44 hypothetical protein flj10803

HHAT hedgehog acyltransferase

FRMD4A ferm domain containing 4a

URG4 up-regulated gene 4

ZNF446 zinc finger protein 446

NAGK n-acetylglucosamine kinase

MAML3 mastermind-like 3 (drosophila)

MCM10 mcm10 minichromosome maintenance deficient 10 (s. cerevisiae)

LRRC59 leucine rich repeat containing 59

CCDC91 hypothetical protein

C4orf19 hypothetical protein flj11017

RNF220 ring finger protein 220

ARMC4 armadillo repeat containing 4

WDR70 wd repeat domain 70

EN0X1 proliferation-inducing protein 38

PID1 hypothetical protein flj20701

LPCAT2 lysophosphatidylcholine acyltransferase 2

FLJ20184 hypothetical protein flj20184

DYM dymeclin

DCHS2 dachsous 2 (drosophila)

A2BP1 ataxin 2-binding protein 1

MARCH5 membrane-associated ring finger (c3hc4) 5

UGT1A9 udp glucuronosyltransferase 1 family, polypeptide a9

EGLN1 egl nine homolog 1 (c. elegans)

UGT1A8 udp glucuronosyltransferase 1 family, polypeptide a8

UGT1A10 udp glucuronosyltransferase 1 family, polypeptide a10

EPB41 L4B erythrocyte membrane protein band 4.1 like 4b

GF0D1 glucose-fructose oxidoreductase domain containing 1

MRPL39 mitochondrial ribosomal protein I39

CNTN5 neural adhesion molecule

MY03A myosin iiia

LRP1 B low density lipoprotein-related protein 1 b (deleted in tumors)

ZAK sterile alpha motif and leucine zipper containing kinase azk

WWOX putative oxidoreductase

CYB5R1 cytochrome b5 reductase 1

NAG dkfzp586g1219 protein

LARS leucyl-trna synthetase

GALNAC4S-6ST kiaaO598 gene product

TA0K3 tao kinase 3

MRPL27 mitochondrial ribosomal protein I27

CRIM1 cysteine rich transmembrane bmp regulator 1 (chordin-like)

PLCE1 phospholipase c, epsilon 1

DBR1 debranching enzyme homolog 1 (s. cerevisiae)

SLC45A2 solute carrier family 45, member 2

TNNI3K tnni3 interacting kinase

FAM135B c8orfk32 protein

PLEKHA9 pleckstrin homology domain containing, family a (phosphoinositide binding specific) member 9

PI15 peptidase inhibitor 15

PDE11A phosphodiesterase 11 a

IMPG2 interphotoreceptor matrix proteoglycan 2

SP0CK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3

KCNIP1 kv channel interacting protein 1

SEC61A1 sec61 alpha 1 subunit (s. cerevisiae)

NME7 non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)

UHRF1 ubiquitin-like, containing phd and ring finger domains, 1

MRPL18 mitochondrial ribosomal protein 118

SETD2 huπtingtin interacting protein b

SNX24 sorting nexing 24

RBMS3 rna binding motif, single stranded interacting protein

CYFIP2 cytoplasmic fmr1 interacting protein 2

NBEA neurobeachin

SMR3A submaxillary gland androgen regulated protein 3 homolog a (mouse)

ERC2 caz-associated structural protein

SENP6 sumoi/sentrin specific peptidase 6

4-

AUTS2 autism susceptibility candidate 2

CNTNAP2 contactin associated protein-like 2

ATRNL1 attractin-like 1

AC0T11 acyl-coa thioesterase 11

MT01 mitochondrial translation optimization 1 homolog (s. cerevisiae)

ZNF324 zinc finger protein 324

FLRT3 fibronectin leucine rich transmembrane protein 3

0SBP2 oxysterol binding protein 2

PATZ1 zinc finger protein 278

RIMBP2 rims binding protein 2

AP4E1 adaptor-related protein complex 4, epsilon 1 subunit

KIAA0776 kiaaO776

VPS8 kiaa0804

D0CK9 dedicator of cytokinesis 9

SYNE1 spectrin repeat containing, nuclear envelope 1

WDR7 wd repeat domain 7

CL.ASP1 cytoplasmic linker associated protein 1

NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like

LPHN3 latrophilin 3

KIAA0774 kiaaO774

KLHL18 kelch-like 18 (drosophila)

DIP2A dip2 disco-interacting protein 2 homolog a (drosophila)

MPRIP myosin phosphatase Rho interacting protein

FSTL4 follistatin-like 4

JMJD2C jumoπji domain containing 2c

MYT1 L myelin transcription factor 1-like

PDZD2 pdz domain containing 2

TMCC1 transmembrane and coiled-coil domain family 1

PALLD palladin, cytoskeletal associated protein

DIP2C dip2 disco-interacting protein 2 homolog c (drosophila)

TCF25 nulpi

KIN kin, antigenic determinant of reca protein homolog (mouse)

ARSG arylsulfatase g

Ul

INPP5F inositol polyphosphate-5-phosphatase f

LAM B4 laminin, beta 4

AKAP13 lymphoid blast crisis oncogene

SEC23IP sec23 interacting protein

PTPRT protein tyrosine phosphatase, receptor type, t

HIBADH 3-hydroxyisobutyrate dehydrogenase

ADAMTS5 adam metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)

POLS polymerase (dna directed) sigma

KDELR2 kdel (lys-asp-glu-leu) endoplasmic reticulum protein retention receptor 2

PPARGC1A peroxisome proliferative activated receptor, gamma, coactivator 1 , alpha

CHL1 cell adhesion molecule with homology to 11 cam (close homolog of 11)

NRG3 neuregulin 3

CORIN corin, serine peptidase

CUGBP2 cug triplet repeat, rna binding protein 2

HY0U1 hypoxia up-regulated 1

VAV3 vav 3 oncogene

DLC1 deleted in liver cancer 1

ABCC4 atp-binding cassette, sub-family c (cftr/mrp), member 4

PSMD14 proteasome (prosome, macropain) 26s subunit, non-atpase, 14

FARP 1 ferm, rhogef (arhgef) and pleckstrin domain protein 1 (chondrocyte-dehved)

RAD50 rad50 homolog (s. cerevisiae)

HS3ST4 heparan sulfate (glucosamine) 3-o-sulfotransferase 4

FAM20B family with sequence similarity 20, member b

G3BP2 ras-gtpase activating protein sh3 domain-binding protein 2

RBM19 rna binding motif protein 19

SRGAP3 slit-robo rho gtpase activating protein 3

TBC 1 D4 tbd domain family, member 4

KIAA0644 kiaaO644 gene product

MAGI2 membrane associated guanylate kinase, ww and pdz domain containing 2

SFH sfi1 homolog, spindle assembly associated (yeast)

N0S1AP nitric oxide synthase 1 (neuronal) adaptor protein

TRAM2 translocation associated membrane protein 2

DEPDC5 dep domain containing 5

IQCB1 iq motif containing b1

SH3PXD2A sh3 and px domains 2a

WTAP wilms tumor 1 associated protein

CREB5 camp responsive element binding protein 5

FHL5 four and a half Nm domains 5

NRXN3 neurexin 3

GTF3C4 general transcription factor iiic, polypeptide 4, 90kda

CD83 cd83 antigen (activated b lymphocytes, immunoglobulin superfamily)

STK17A serine/threonine kinase 17a (apoptosis-inducing)

MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2

MAGH membrane associated guanylate kinase, ww and pdz domain containing 1

LARGE like-glycosyltransferase

CLDN1 claudin 1

PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1

WASL wiskott-aldrich syndrome-like

MGAM maltase-glucoamylase (alpha-glucosidase)

SYNJ1 synaptojanin 1

PR0M1 prominin 1

WISP2 wnt1 inducible signaling pathway protein 2

INPP4B inositol polyphosphate-4-phosphatase, type ii, 105kda

CREG1 cellular repressor of e1 a-stimulated genes 1

EIF4G3 eukaryotic translation initiation factor 4 gamma, 3

TP63 tumor protein p73-like

US01 vesicle docking protein p115

GAS7 growth arrest-specific 7

ITGA8 integrin, alpha 8

CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase

S0RBS2 sorbin and sh3 domain containing 2

BB0X1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1

C16orf35 chromosome 16 open reading frame 35

ADAM 12 adam metallopeptidase domain 12 (meltrin alpha) -

BAT2 hla-b associated transcript 2

-J -J ZNF66 zinc finger protein 66

YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

VWF von willebrand factor

USH2A usher syndrome 2a (autosomal recessive, mild)

DNAJC7 dnaj (hsp40) homolog, subfamily c, member 7

TSSC1 tumor suppressing subtransferable candidate 1

TRIO triple functional domain (ptprf interacting)

TMPRSS2 transmembrane protease, serine 2

TGFA transforming growth factor, alpha

TCP1 t-complex 1

SYK spleen tyrosine kinase

SSR1 signal sequence receptor, alpha (traπslocon-associated protein alpha)

SOX5 sry (sex determining region y)-box 5

SORL1 sortilin-related receptor, l(dlr class) a repeats-containing

SNCA synuclein, alpha (non a4 component of amyloid precursor)

SMARCA2 swi/snf related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

SLC6A2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2

SLC6A1 solute carrier family 6 (neurotransmitter transporter, gaba), member 1

ST8SIA1 st8 alpha-n-acetyl-neuraminide alpha-2,8-sialyltransferase 1

FBXW4 f-box and wd-40 domain protein 4

SELP selectin p (granule membrane protein 140kda, antigen cd62)

SCN3A sodium channel, voltage-gated, type iii, alpha

RPN1 ribophorin i

RORA rar-related orphan receptor a

R0B02 roundabout, axon guidance receptor, homolog 2 (drosophila)

RAP1 GDS1 rap1 , gtp-gdp dissociation stimulator 1

RAC 1 ras-related c3 botulinum toxin substrate 1 (rho family, small gtp binding protein rac1)

PTPRM protein tyrosine phosphatase, receptor type, m

PTGFR prostaglandin f receptor (fp)

PRKCA protein kinase c, alpha

PRIM2 primase, polypeptide 2a, 58kda

PPP2R5C protein phosphatase 2, regulatory subunit b (b56), gamma isoform

PPIC peptidylprolyl isomerase c (cyclophilin c)

UBL3 ubiquitin-like 3

OO

PLXNA2 plexin a2

PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)

PDE9A phosphodiesterase 9a

PDE6A phosphodiesterase 6a, cgmp-specific, rod, alpha

PDE4D phosphodiesterase 4d, camp-specific (phosphodiesterase e3 dunce homolog, drosophila)

PDE3A phosphodiesterase 3a, cgmp-inhibited

PAX9 paired box gene 9

PAX7 paired box gene 7

PARK2 parkinson disease (autosomal recessive, juvenile) 2, parkin

OPCML opioid binding protein/cell adhesion molecule-like

R0R1 receptor tyrosine kinase-like orphan receptor 1

NTRK3 neurotrophic tyrosine kinase, receptor, type 3

NFATC2 nuclear factor of activated t-cells, cytoplasmic, calcineurin-dependent 2

NELL1 nel-like 1 (chicken)

DRG1 developmentally regulated gtp binding protein 1

MVK mevalonate kinase (mevalonic aciduria)

MMP2 matrix metallopeptidase 2 (gelatinase a, 72kda gelatinase, 72kda type iv collagenase)

NR3C2 nuclear receptor subfamily 3, group c, member 2

ME0X2 mesenchyme homeobox 2

MBNL1 muscleblind-like (drosophila)

LTBP2 latent transforming growth factor beta binding protein 2

LIPA lipase a, lysosomal acid, cholesterol esterase (wolman disease)

LIMK2 lim domain kinase 2

KIT v-kit hardy-zuckerman 4 feline sarcoma viral oncogene homolog

KCN H 1 potassium voltage-gated channel, subfamily h (eag-related), member 1

JARID2 jumonji, at rich interactive domain 2

ITGB6 integrin, beta 6

IGF1 R insulin-like growth factor 1 receptor

HLA-DQA2 major histocompatibility complex, class ii, dq alpha 1

NRG1 neuregulin 1

GRIA1 glutamate receptor, ionotropic, ampa 1

GPLD1 glycosylphosphatidylinositol specific phospholipase d1

GABRB3 gamma-aminobutyric acid (gaba) a receptor, beta 3

VO

GABRB2 gamma-aminobutyric acid (gaba) a receptor, beta 2

FN1 fibronectin 1

FHIT fragile histidine triad gene

FABP6 fatty acid binding protein 6, ileal (gastrotropin)

F5 coagulation factor v (proaccelerin, labile factor)

ERN1 endoplasmic reticulum to nucleus signalling 1

ERG v-ets erythroblastosis virus e26 oncogene like (avian)

EYA4 eyes absent homolog 4 (drosophila)

EPRS glutamyl-prolyl-trna synthetase

EGFR epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

DPP6 dipeptidyl-peptidase 6

D0CK1 dedicator of cytokinesis 1

DLG2 discs, large homolog 2, chapsyn-110 (drosophila)

DAPK1 death-associated protein kinase 1

DAD1 defender against cell death 1

CTNNB1 catenin (cadherin-associated protein), beta 1 , 88kda

CTNNA2 catenin (cadherin-associated protein), alpha 2

HAPLN1 hyaluronan and proteoglycan link protein 1

COX10 cox10 homolog, cytochrome c oxidase assembly protein, heme a: farnesyltransferase (yeast)

COL15A1 collagen, type xv, alpha 1

COL13A1 collagen, type xiii, alpha 1

COL6A3 collagen, type vi, alpha 3

COL4A2 collagen, type iv, alpha 2

CNN3 calponin 3, acidic

CLTA clathrin, light polypeptide (lea)

CLCA1 chloride channel, calcium activated, family member 1

CHRM2 cholinergic receptor, muscarinic 2

CDH6 cadherin 6, type 2, k-cadhehn (fetal kidney)

CDH5 cadherin 5, type 2, ve-cadherin (vascular epithelium)

CDH4 cadherin 4, type 1 , r-cadherin (retinal)

CDH3 cadherin 3, type 1 , p-cadherin (placental)

LRBA , Ips-responsive vesicle trafficking, beach and anchor containing

OO CALD1 caldesmon 1 O

CALCR calcitonin receptor

CACNB4 calcium channel, voltage-dependent, beta 4 subunit

CACNB2 calcium channel, voltage-dependent, beta 2 subunit

BLVRA biliverdin reductase a

BBS4 bardet-biedl syndrome 4

ZFHX3 at-binding transcription factor 1

APBB2 amyloid beta (a4) precursor protein-binding, family b, member 2 (fe65-like)

ANK2 ankyrin 2, neuronal

AMPH amphiphysin (stiff-man syndrome with breast cancer 128kda autoantigen)

AMBP alpha-1 -microglobulin/bikunin precursor

ALOX5 arachidonate 5-lipoxygenase

ALK anaplastic lymphoma kinase (ki-1 )

ADCY8 adenylate cyclase 8 (brain)

ADARB1 adenosine deaminase, ma-specific, b1 (red1 homolog rat)

ACO1 aconitase 1 , soluble

ACCN1 amiloride-sensitive cation channel 1 , neuronal (degenerin)

ACAT2 acetyl-coenzyme a acetyltransferase 2 (acetoacetyl coenzyme a thiolase)

ABCA1 atp-binding cassette, sub-family a (abd), member 1

rs10161338 124.97 logistic AGE:SEX Ml vs no Ml (at entry) 12 0.000219 1.43 rs10161338 124.97 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0003269 1.43 rs10161338 124.97 logistic Ml vs no Ml (at entry) 12 0.0003459 1.43 rs10161338 124.97 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0003613 1.43 rs10161338 124.97 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 0.0003657 1.43 rs10161338 124.97 logistic AGE:SEX Ml vs no Ml (follow-up) 12 0.0004036 1.40 rs1017213 165.12 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0002199 0.80 rs1017213 165.12 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.0002929 0.81 rs10183453 160.24 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 3.85E-05 0.59 rs10183453 160.24 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 4.79E-05 0.64 rs10183453 160.24 logistic GE:AGE:SEX Ml vs control (at entry) 2 5.77E-05 0.59 rs10183453 160.24 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 7.01 E-05 0.64 rs10183453 160.24 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 7.55E-05 0.64 rs10183453 160.24 logistic Ml vs control (at entry) 2 9.46E-05 0.59 rs10183453 160.24 logistic Ml vs no Ml (at entry) 2 0.000106 0.64 rs10183453 160.24 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.000125 0.64 rs10183453 160.24 logistic AGElSEX Ml vs control (at entry) 2 0.0001389 0.59 rs10183453 160.24 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0001977 0.67 rs10183453 160.24 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0002769 0.67 rs10183453 160.24 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 0.0003809 0.67 rs10183453 160.24 logistic Ml vs no Ml (follow-up) 2 0.0003946 0.67 rs10183453 160.24 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0004787 0.67 rs10186075 131.26 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0002593 0.79 rs1019219 127.53 logistic AGE:SEX Ml vs control (at entry) 7 0.0004098 1.69 rs10193182 80.05 logistic AGE:SEX Ml vs control (at entry) 2 0.0001153 0.73 rs10193182 80.05 logistic Ml vs control (at entry) 2 0.0002308 0.73 rs10193182 80.05 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0003588 0.80 rs10193182 80.05 logistic GE:AGE:SEX Ml vs control (at entry) 2 0.0004455 0.73 rs10195506 141.54 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0001737 0.79 rs10195506 141.54 logistic AGE:SEX Ml vs no Mi (at entry) 2 0.0003597 0.79 rs10195506 141.54 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0004276 0.79 rs10210369 168.73 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0001192 1.34 rs10210369 168.73 logistic GE:AGE:SEX Ml vs control (at entry) 2 0.0001621 1.34 rs10210369 168.73 logistic AGE:SEX Ml vs control (at entry) 2 0.0004366 1.34 rs10211389 48.92 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 2 0.0003318 0.70 rs10211389 48.92 logistic Ml vs control (follow-up) 2 0.000413 0.70

rs10222420 176.88 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 2.39E-06 1.54 rs 10222420 176.88 logistic Ml vs control (follow-up) 3 0.0001521 1.54 rs 10222420 176.88 logistic AGE:SEX Ml vs control (follow-up) 3 0.0002969 1.54 rs1024654 71.39 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 17 0.0002296 1.46 rs10281059 52.24 logistic GE:AGE:SEX Ml vs no Ml (at entry) 7 3.16E-05 0.20 rs10281059 52.24 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 7 4.58E-05 0.20 rs10281059 52.24 logistic Ml vs no Ml (at entry) 7 4.61 E-05 0.20 rs10281059 52.24 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 7 4.88E-05 0.20 rs10281059 52.24 logistic AGE:SEX Ml vs no Ml (at entry) 7 6.74E-05 0.20 rs10281059 52.24 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 7 8.69E-05 0.20 rs10281059 52.24 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 0.0002139 0.31 rs10281059 52.24 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0002616 0.23 rs10281059 52.24 logistic Ml vs no Ml (follow-up) 7 0.0002738 0.31 rs10281059 52.24 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 0.0003414 0.31 rs10281059 52.24 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.0003535 0.31 rs10281059 52.24 logistic AGE:SEX Ml vs control (at entry) 7 0.0004192 0.23 rs10281059 52.24 logistic AGE:SEX Ml vs no Ml (follow-up) 7 0.0004489 0.31 rs10281059 52.24 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 0.0004852 0.23

OO rs1028932 56.37 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 6.75E-05 1.20 rs1028932 56.37 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0001389 1.19 rs1036515 118.40 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0004715 0.85 rs1040404 183.46 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 4.58E-05 0.80 rs1040404 183.46 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 8.48E-05 0.83 rs10426996 99.73 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 19 0.0002048 0.57 rs10439056 81.58 logistic Ml vs no Ml (follow-up) 18 0.0002537 1.64 rs10439056 81.58 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0002976 1.64 rs10439056 81.58 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 0.0003076 1.64 rs10439056 81.58 logistic AGE:SEX Ml vs no Ml (follow-up) 18 0.0003621 1.64 rs10439056 81.58 logistic Ml vs no Ml (at entry) 18 0.00043 1.61 rs10439056 81.58 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0004606 1.61 rs10439056 81.58 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0004772 1.61 rs10471462 68.68 logistic AGE:SEX Ml vs control (at entry) 5 0.0001205 0.63 rs10471462 68.68 logistic Ml vs control (at entry) 5 0.0001237 0.63 rs 10474222 95.19 logistic GE:AGE:SEX Ml vs control (follow-up) 5 0.0002145 0.53 rs10474222 95.19 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0002225 0.58 rs10474222 95.19 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.000281 0.59

rs10474222 95.19 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0002865 0.58 rs10474222 95.19 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0002874 0.58 rs10474222 95.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.000296 0.58 rs 10474222 95.19 logistic Ml vs no Ml (at entry) 5 0.0003255 0.58 rs 10474222 95.19 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0003302 0.59 rs10474222 95.19 logistic Ml vs no Ml (follow-up) 5 0.0003376 0.59 rs10474222 95.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0003441 0.59 rs10474222 95.19 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 5 0.0003604 0.53 rs10474222 95.19 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 5 0.0003688 0.53 rs10474222 95.19 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.0003831 0.59 rs10474312 97.95 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0002246 0.73 rs10474312 97.95 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0002752 0.73 rs10474312 97.95 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0003523 0.73 rs10484338 26.55 logistic GE:AGE:SEX Ml vs control (at entry) 6 0.0004307 0.63 rs10485214 154.05 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 6 0.0002367 0.49 rs10485214 154.05 logistic AGE:SEX Ml vs control (follow-up) 6 0.0002403 0.49 rs10485214 154.05 logistic Ml vs control (follow-up) 6 0.0002908 0.49 rs10485214 154.05 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 6 0.0004876 0.49 rs10488899 111.31 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0002331 1.28 rs10489434 71.02 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.0002803 1.27 rs10493090 70.80 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 1 0.0002469 1.28 rs10497186 161.59 logistic AGE:SEX Ml vs control (at entry) 2 0.000328 0.46 rs10497186 161.59 logistic AGE:SEX Ml vs control (follow-up) 2 0.0003961 0.44 rs10497186 161.59 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0004195 0.46 rs10501798 91.90 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 11 4.78E-05 1.15 rs10501798 91.90 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 11 0.0004855 1.15 rs10503813 54.36 logistic AGE:SEX Ml vs control (at entry) 8 0.000336 0.73 rs10503813 54.36 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0003656 0.76 rs10504841 102.00 logistic GE:AGE:SEX Ml vs control (follow-up) 8 3.92E-05 0.54 rs10504841 102.00 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 8 0.0001167 0.54 rs 10504841 102.00 logistic Ml vs control (follow-up) 8 0.0001325 0.54 rs10504841 102.00 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0001397 0.61 rs10504841 102.00 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 0.0001583 0.61 rs10504841 102.00 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.0001941 0.54 rs10504841 102.00 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0002014 0.61 rs10504841 102.00 logistic AGE:SEX Ml vs control (follow-up) 8 0.0002042 0.54

rs10504841 102.00 logistic Ml vs no Ml (follow-up) 8 0.0002106 0.61 rs10504841 102.00 logistic Ml vs no Ml (at entry) 8 0.0002199 0.61 rs10504841 102.00 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0002311 0.61 rs10504841 102.00 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0004419 0.61 rs10504841 102.00 logistic AGEiSEX Ml vs no Ml (at entry) 8 0.0004557 0.61 rs10504841 102.00 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 8 0.0004995 0.61 rs10504880 102.24 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0002679 0.76 rs10504880 102.24 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0003217 0.76 rs10504880 102.24 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 8 0.0003339 0.77 rs10504880 102.24 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 0.0003434 0.76 rs10504880 102.24 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0003925 0.77 rs10504880 102.24 logistic AGE:SEX Ml vs no Ml (at entry) 8 0.0004733 0.76 rs10504880 102.24 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0004765 0.77 rs10505346 125.76 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.000345 0.69 rs10505349 125.77 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.0003602 0.69 rs10509812 126.45 logistic GE:AGE:SEX Ml vs control (follow-up) 10 0.0002276 1.52 rs10509812 126.45 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 10 0.0003019 1.52 rs10509812 126.45 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0003485 1.32 rs10509812 126.45 logistic GE:AGE:SEX Ml vs control (at entry) 10 0.0003635 1.43 rs10509812 126.45 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 0.000441 1.43 rs10510115 145.95 logistic Ml vs no Ml (follow-up) 10 6.62E-07 1.75 rs10510115 145.95 logistic Ml vs no Ml (at entry) 10 7.45E-07 1.75 rs10510115 145.95 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 1.84E-06 1.75 rs10510115 145.95 logistic AGE:SEX Ml vs no Ml (at entry) 10 1.85E-06 1.75 rs10510115 145.95 logistic AGEiSEX Ml vs no Ml (follow-up) 10 1.91 E-06 1.75 rs10510115 145.95 logistic GEiAGEiCRCLiSEX Ml vs no Ml (follow-up) 10 1.92E-06 1.75 rs10510115 145.95 logistic GEiAGEiCRCLiSEX Ml vs no Ml (at entry) 10 1.92E-06 1.75 rs10510115 145.95 logistic GEIAGEISEX Ml vs no Ml (follow-up) 10 2.31 E-06 1.75 rs10510115 145.95 logistic GEIAGEISEX Ml vs no Ml (at entry) 10 2.35E-06 1.75 rs10510115 145.95 logistic GEiAGEiACRiSEX Ml vs no Ml (follow-up) 10 2.49E-06 1.75 rs10510115 145.95 logistic Ml vs control (at entry) 10 1.57E-05 1.91 rs10510115 145.95 logistic AGEiSEX Ml vs control (at entry) 10 1.85E-05 1.91 rs10510115 145.95 logistic GEIAGEICRCLISEX Ml vs control (at entry) 10 3.19E-05 1.91 rs10510115 145.95 logistic GEIAGEISEX Ml vs control (at entry) 10 4.02E-05 1.91 rs10510115 145.95 logistic Ml vs control (follow-up) 10 0.0001295 1.90 rs10510115 145.95 logistic HBPIGEIAGEISEX Ml vs no Ml (follow-up) 10 0.0001693 1.75

rs10510115 145.95 logistic AGE:SEX Ml vs control (follow-up) 10 0.0001806 1.90 rs10510115 145.95 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0001847 1.75 rs10510115 145.95 logistic GE:AGE:SEX Ml vs control (follow-up) 10 0.0002149 1.90 rs10510115 145.95 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 10 0.0002374 1.90 rs10510650 58.29 logistic Ml vs no Ml (at entry) 3 0.0001047 1.39 rs10510650 58.29 logistic Ml vs no Ml (follow-up) 3 0.00011 1.39 rs10510650 58.29 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0001574 1.39 rs10510650 58.29 logistic AGE:SEX Ml vs no Ml (follow-up) 3 0.0001756 1.39 rs10510650 58.29 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.000178 1.39 rs10510650 58.29 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0001913 1.39 rs10511782 48.14 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 5.88E-05 1.31 rs10511782 48.14 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0001785 1.29 rs10511782 48.14 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 9 0.0004098 1.31 rs10511782 48.14 logistic GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0004713 1.31 rs10512942 17.84 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0002583 0.79 rs10514064 107.88 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 4.40E-05 1.40 rs10514064 107.88 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 5.86E-05 1.39 rs10514064 107.88 logistic Ml vs no Ml (at entry) 18 0.0001182 1.40 rs10514064 107.88 logistic Ml vs no Ml (follow-up) 18 0.000136 1.39 rs10514064 107.88 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0002042 1.40 rs10514064 107.88 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.000264 1.39 rs10514064 107.88 logistic AGEiSEX Ml vs no Ml (at entry) 18 0.0002697 1.40 rs10514064 107.88 logistic AGEiSEX Ml vs no Ml (follow-up) 18 0.0003521 1.39 rs10514064 107.88 logistic GEiAGEiACRiSEX Ml vs no Ml (follow-up) 18 0.0003869 1.39 rs10514064 107.88 logistic GEiAGEiACRiSEX Ml vs no Ml (at entry) 18 0.0003969 1.40 rs10514064 107.88 logistic GEiAGEiCRCLiSEX Ml vs no Ml (at entry) 18 0.0004321 1.40 rs10514925 63.91 logistic Ml vs control (at entry) 17 9.80E-05 2.15 rs10514925 63.91 logistic AGEiSEX Ml vs control (at entry) 17 0.0001008 2.15 rs10514925 63.91 logistic GEIAGEISEX Ml vs control (at entry) 17 0.00017 2.15 rs10514925 63.91 logistic GEIAGEICRCLISEX Ml vs control (at entry) 17 0.0002879 2.15 rs10519051 53.30 logistic GEIAGEIACRISEX Ml vs no Ml (at entry) 15 7.96E-05 1.43 rs10519051 53.30 logistic AGEISEX Ml vs no Ml (at entry) 15 0.000157 1.43 rs10519051 53.30 logistic Ml vs no Ml (at entry) 15 0.0001896 1.43 rs10519051 53.30 logistic GEIAGEISEX Ml vs no Ml (at entry) 15 0.0001948 1.43 rs10519051 53.30 logistic GEIAGEICRCLISEX Ml vs no Ml (at entry) 15 0.0002161 1.43 rs10519051 53.30 logistic GEIAGEIACRISEX Ml vs control (at entry) 15 0.0003408 1.43

rs10519051 53.30 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 15 0.000452 1.38 rs10519085 54.08 logistic AGE:SEX Ml vs no Ml (follow-up) 15 0.0003278 0.78 rs10519085 54.08 logistic AGE:SEX Ml vs no Ml (at entry) 15 0.0003463 0.78 rs10519085 54.08 logistic Ml vs no Ml (follow-up) 15 0.0003481 0.78 rs10519085 54.08 logistic Ml vs no Ml (at entry) 15 0.0003619 0.78 rs10734480 49.68 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0004869 1.32 rs10738885 56.37 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.000341 1.18 rs10738885 56.37 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 0.000441 1.17 rs10738885 56.37 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 9 0.0004704 1.16 rs10741552 18.01 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 11 5.81 E-05 0.53 rs10741552 18.01 logistic Ml vs control (follow-up) 11 9.70E-05 0.53 rs10741552 18.01 logistic AGE:SEX Ml vs control (follow-up) 11 0.0001319 0.53 rs10741552 18.01 logistic Ml vs control (at entry) 11 0.0002249 0.56 rs10741552 18.01 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.000229 0.56 rs10741552 18.01 logistic AGE:SEX Ml vs control (at entry) 11 0.0003512 0.56 rs1074156 66.11 logistic AGE:SEX Ml vs control (follow-up) 11 0.0001205 1.43 rs1074156 66.11 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0002451 1.29 rs1074156 66.11 logistic Ml vs control (follow-up) 11 0.0003093 1.43

OO rs1074156 66.11 logistic Ml vs no Ml (at entry) 11 0.0004317 1.29 rs1074156 66.11 logistic AGE:SEX Ml vs control (at entry) 11 0.0004382 1.35 rs10743478 43.09 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.0003848 1.30 rs10743478 43.09 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 0.0004816 1.23 rs10743879 20.38 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 0.0003187 1.73 rs10745995 112.09 logistic AGE:SEX Ml vs no Ml (at entry) 12 0.0003871 1.46 rs10745995 112.09 logistic Ml vs no Ml (at entry) 12 0.0004229 1.46 rs10745996 112.09 logistic AGE:SEX Ml vs no Ml (at entry) 12 0.0003515 1.47 rs10745996 112.09 logistic Ml vs no Ml (at entry) 12 0.0003989 1.47 rs10746342 93.75 logistic Ml vs control (follow-up) 12 6.64E-05 0.63 rs10746342 93.75 logistic AGE:SEX Ml vs control (follow-up) 12 9.73E-05 0.63 rs10746342 93.75 logistic Ml vs control (at entry) 12 0.0001061 0.66 rs10746342 93.75 logistic AGE:SEX Ml vs control (at entry) 12 0.0001176 0.66 rs10746342 93.75 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 0.0002825 0.63 rs10746342 93.75 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0003531 0.66 rs10750359 129.15 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 11 0.0002462 0.79 rs10750359 129.15 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0002972 0.79 rs10750359 129.15 logistic AGE:SEX Ml vs no Ml (follow-up) 11 0.0004006 0.79

rs10755926 134.76 logistic Ml vs control (at entry) 8 0.0001358 1.40 rs10755926 134.76 logistic AGE:SEX Ml vs control (at entry) 8 0.0002869 1.40 rs10755926 134.76 logistic Ml vs no Ml (at entry) 8 0.0004871 1.28 rs10759217 114.50 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 9 0.0001441 0.88 rs10760333 135.47 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 9 4.82E-05 1.27 rs10765565 91.90 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 11 0.0001896 1.11 rs10772017 53.36 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 12 0.0002455 1.37 rs10772017 53.36 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.0004059 1.37 rs10774703 120.87 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0002091 1.25 rs10774703 120.87 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.0002898 1.24 rs10774703 120.87 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0004035 1.25 rs10774703 120.87 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.000415 1.25 rs1077861 62.28 logistic GE:AGE:SEX Ml vs control (at entry) 16 0.0003734 1.35 rs1077861 62.28 logistic GE:AGE:SEX Ml vs no Ml (at entry) 16 0.0004358 1.28 rs10778928 92.53 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.000353 0.70 rs10779158 93.74 logistic Ml vs control (at entry) 12 0.0001542 0.71 rs10779158 93.74 logistic Ml vs control (follow-up) 12 0.000223 0.70 rs10779158 93.74 logistic AGEiSEX Ml vs control (at entry) 12 0.0002451 0.71

00 rs10779158 93.74 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0003513 0.71 rs10779158 93.74 logistic AGEiSEX Ml vs control (follow-up) 12 0.0004978 0.70 rs10780685 65.75 logistic Ml vs control (follow-up) 9 0.0003317 1.42 rs10793682 155.30 logistic Ml vs control (at entry) 1 0.0002542 1.76 rs10793682 155.30 logistic AGEiSEX Ml vs control (at entry) 1 0.0002776 1.76 rs10801047 205.42 logistic GEiAGEiACRiSEX Ml vs no Ml (follow-up) 1 5.64E-05 1.64 rs10801047 205.42 logistic Ml vs no Ml (follow-up) 1 6.54E-05 1.64 rs10801047 205.42 logistic Ml vs no Ml (at entry) 1 8.65E-05 1.63 rs10801047 205.42 logistic GEiAGEiACRiSEX Ml vs no Ml (at entry) 1 8.65E-05 1.63 rs10801047 205.42 logistic GEiAGEiCRCLSEX Ml vs no Ml (follow-up) 1 0.0001128 1.64 rs10801047 205.42 logistic AGEiSEX Ml vs no Ml (follow-up) 1 0.0001305 1.64 rs10801047 205.42 logistic GEIAGEICRCLSEX Ml vs no Ml (at entry) 1 0.0001368 1.63 rs10801047 205.42 logistic GEIAGEISEX Ml vs no Ml (follow-up) 1 0.0001398 1.64 rs10801047 205.42 logistic AGEISEX Ml vs no Ml (at entry) 1 0.0001592 1.63 rs10801047 205.42 logistic GEIAGEISEX Ml vs no Ml (at entry) 1 0.0001735 1.63 rs10802580 257.32 logistic GEIAGEIACRISEX Ml vs control (at entry) 1 0.0003329 0.74 rs10808479 124.55 logistic GEIAGEISEX Ml vs no Ml (at entry) 8 0.000364 0.78 rs10808479 124.55 logistic GEIAGEICRCLSEX Ml vs no Ml (at entry) 8 0.0003862 0.78

rs10808479 124.55 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 0.0004949 0.75 rs10809509 2.75 logistic GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0001003 1.30 rs10809509 2.75 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0001006 1.30 rs10809509 2.75 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 9 0.0001193 1.30 rs10809509 2.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0001279 1.30 rs10809509 2.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0001323 1.30 rs10809509 2.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 9 0.0001443 1.30 rs10809509 2.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 9 0.0001445 1.30 rs10809509 2.75 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 9 0.0001774 1.33 rs10809509 2.75 logistic AGE:SEX Ml vs no Ml (follow-up) 9 0.0001779 1.30 rs10809509 2.75 logistic AGEiSEX Ml vs no Ml (at entry) 9 0.0001927 1.30 rs10809509 2.75 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 9 0.0002049 1.30 rs10809509 2.75 logistic Ml vs no Ml (at entry) 9 0.0002797 1.30 rs10809509 2.75 logistic Ml vs no Ml (follow-up) 9 0.000281 1.30 rs10809509 2.75 logistic GE:AGE:SEX Ml vs control (at entry) 9 0.0004519 1.33 rs10809509 2.75 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 9 0.0004798 1.33 rs10815384 1.48 logistic Ml vs no Ml (follow-up) 9 4.42E-05 0.67 rs10815384 1.48 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 9 5.08E-05 0.67 rs10815384 1.48 logistic AGE:SEX Ml vs no Ml (follow-up) 9 7.37E-05 0.67 rs10815384 1.48 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 7.57E-05 0.67 rs10815384 1.48 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0001228 0.67 rs10815384 1.48 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 9 0.0001829 0.67 rs10815385 1.48 logistic Ml vs no Ml ^' (follow-up) 9 4.81 E-05 0.67 rs10815385 1.48 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 9 5.42E-05 0.67 rs10815385 1.48 logistic AGE:SEX Ml vs no Ml (follow-up) 9 7.22E-05 0.67 rs10815385 1.48 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 7.88E-05 0.67 rs10815385 1.48 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0001435 0.67 rs10815385 1.48 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 9 0.0002041 0.67 rs10815386 1.48 logistic Ml vs no Ml (follow-up) 9 4.42E-05 0.67 rs10815386 1.48 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 9 5.08E-05 0.67 rs10815386 1.48 logistic AGE:SEX Ml vs no Ml (follow-up) 9 7.37E-05 0.67 rs10815386 1.48 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 7.57E-05 0.67 rs10815386 1.48 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0001228 0.67 rs10815386 1.48 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 9 0.0001829 0.67 rs10815387 1.48 logistic Ml vs no Ml (follow-up) 9 7.15E-05 0.68 rs10815387 1.48 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 9 8.16E-05 0.68

rs10815387 1.48 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0001213 0.68 rs10815387 1.48 logistic AGE:SEX Ml vs no Ml (follow-up) 9 0.0001228 0.68 rs10815387 1.48 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0002108 0.68 rs10815387 1.48 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 9 0.0002887 0.68 rs10823420 89.35 logistic Ml vs control (at entry) 10 0.000341 1.41 rs10823420 89.35 logistic AGE:SEX Ml vs control (at entry) 10 0.0004907 1.41 rs10824378 96.57 logistic Ml vs control (at entry) 10 0.0003785 0.70 rs10824541 98.56 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 0.0001851 1.46 rs10824541 98.56 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.000217 1.46 rs10824541 98.56 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0003077 1.46 rs10824541 98.56 logistic Ml vs no Ml (follow-up) 10 0.0004375 1.46 rs10824541 98.56 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.0004485 1.46 rs 10825228 73.83 logistic Ml vs control (at entry) 10 0.0003869 1.37 rs10825228 73.83 logistic AGE:SEX Ml vs control (at entry) 10 0.0004392 1.37 rs10827750 64.15 logistic AGE:SEX Ml vs control (at entry) 10 9.10E-05 1.40 rs10827750 64.15 logistic Ml vs control (at entry) 10 0.000184 1.40 rs10827750 64.15 logistic AGE:SEX Ml vs control (follow-up) 10 0.000277 1.41 rs10827750 64.15 logistic Ml vs control (follow-up) 10 0.0004813 1.41

O rs10828660 49.49 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 5.19E-05 1.29 rs10828660 49.49 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 10 0.0003425 1.29 rs10836005 8.62 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 0.0003251 0.73 rs10836005 8.62 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 0.0004051 0.73 rs10836533 46.64 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 11 0.0001791 1.22 rs10836620 47.67 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 11 0.0002754 0.78 rs10836620 47.67 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 0.0002993 0.78 rs10836620 47.67 logistic AGEiSEX Ml vs no Ml (at entry) 11 0.0003602 0.78 rs 10836620 47.67 logistic Ml vs no Ml (at entry) 11 0.0004707 0.78 rs10839816 12.85 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0002148 0.70 rs10839816 12.85 logistic Ml vs no Ml (at entry) 11 0.0002607 0.70 rs10839816 12.85 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 0.0004186 0.70 rs10839816 12.85 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 11 0.0004409 0.70 rs10841292 36.59 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 0.0002644 1.39 rs10842643 45.62 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0003621 1.52 rs10842643 45.62 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0004487 1.51 rs10845552 26.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0004313 1.25 rs10850169 120.87 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0001976 1.25

rs10850169 120.87 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.0002737 1.24 rs10850169 120.87 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0003819 1.25 rs10850169 120.87 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.000415 1.25 rs10850169 120.87 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0004664 1.25 rs10850169 120.87 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.0004748 1.24 rs10850913 118.75 logistic GE:AGE:SEX Ml vs control (follow-up) 12 0.0001526 0.68 rs10850913 118.75 logistic AGEiSEX Ml vs control (follow-up) 12 0.0002751 0.68 rs10850913 118.75 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 0.0002851 0.68 rs10850913 118.75 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.000364 0.76 rs10850913 118.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.000452 0.76 rs10851378 36.37 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 15 0.0001367 1.38 rs10851378 36.37 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 15 0.0003757 1.24 rs10860982 110.27 logistic AGE:SEX Ml vs no Ml (at entry) 12 0.000211 0.57 rs10860982 110.27 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 0.000228 0.57 rs10860982 110.27 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0002376 0.57 rs10860982 110.27 logistic Ml vs no Ml (at entry) 12 0.0002385 0.57 rs10860982 110.27 logistic AGE:SEX Ml vs no Ml (follow-up) 12 0.0002406 0.58 rs10860982 110.27 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0002552 0.58

VO rs10860982 110.27 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.0002672 0.58 rs10860982 110.27 logistic Ml vs no Ml (follow-up) 12 0.0002798 0.58 rs10860982 110.27 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.0003322 0.58 rs10860982 110.27 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 0.0004509 0.57 rs10861935 117.30 logistic AGE:SEX Ml vs control (follow-up) 12 0.0002461 0.72 rs10868271 65.79 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 9 0.0001192 0.88 rs10868271 65.79 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 9 0.0001469 0.86 rs10877125 71.94 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 0.0002022 0.78 rs10880791 59.06 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 7.37E-05 1.43 rs10880791 59.06 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.0001085 1.43 rs10880791 59.06 logistic AGE:SEX Ml vs control (at entry) 12 0.0001483 1.43 rs10880791 59.06 logistic Ml vs control (at entry) 12 0.0001549 1.43 rs10884261 126.43 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0003003 1.30 rs10885336 131.17 logistic GE:AGE:CRCLSEX Ml vs no Ml (follow-up) 10 6.83E-05 1.31 rs10885336 131.17 logistic Ml vs no Ml (follow-up) 10 0.000101 1.31 rs10885336 131.17 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0001225 1.31 rs10885336 131.17 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.0001319 1.31 rs10885336 131.17 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.000157 1.31

rs10885336 131.17 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 0.0002552 1.33 rs10885336 131.17 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 10 0.000306 1.38 rs10885336 131.17 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0004156 1.31 rs10885336 131.17 logistic GE:AGE:SEX Ml vs control (follow-up) 10 0.0004806 1.38 rs10885337 131.17 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 7.60E-05 1.30 rs10885337 131.17 logistic Ml vs no Ml (follow-up) 10 0.0001111 1.30 rs10885337 131.17 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0001225 1.30 rs10885337 131.17 logistic AGEiSEX Ml vs no Ml (follow-up) 10 0.0001467 1.30 rs10885337 131.17 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0001739 1.30 rs10885337 131.17 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 0.0002552 1.33 rs10885337 131.17 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 10 0.000306 1.38 rs10885337 131.17 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0004379 1.30 rs10885337 131.17 logistic GE:AGE:SEX Ml vs control (follow-up) 10 0.0004806 1.38 rs10893649 129.13 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0002887 0.78 rs10893649 129.13 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 11 0.0004119 0.78 rs10896380 67.74 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0003321 1.23 rs10898982 76.12 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 11 0.0004765 1.12 rs10901545 153.60 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 5.91 E-05 0.43

K> rs10901545 153.60 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 6.02E-05 0.43 rs10901545 153.60 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 0.0001014 0.43 rs10901545 153.60 logistic Ml vs no Ml (at entry) 10 0.0001241 0.43 rs10901545 153.60 logistic AGE:SEX Ml vs no Ml (at entry) 10 0.0001946 0.43 rs10901545 153.60 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0002805 0.43 rs10901545 153.60 logistic GE:AGE:SEX Ml vs control (at entry) 10 0.0002928 0.46 rs10901545 153.60 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0003544 0.49 rs10901545 153.60 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0004127 0.49 rs10901545 153.60 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 10 0.000489 0.46 rs10923477 151.27 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 1 7.18E-05 0.74 rs10923477 151.27 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.0001344 0.77 rs10941073 49.09 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 3.75E-07 0.15 rs10941073 49.09 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 4.55E-07 0.15 rs10941073 49.09 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 5.26E-07 0.15 rs10941073 49.09 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 7.20E-07 0.15 rs10941073 49.09 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 8.08E-07 0.20 rs10941073 49.09 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 8.54E-07 0.20 rs10941073 49.09 logistic Ml vs no Ml (at entry) 5 8.60E-07 0.15

rs10941073 49.09 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 9.68E-07 0.20 rs10941073 49.09 logistic Ml vs no Ml (follow-up) 5 1.21 E-06 0.20 rs10941073 49.09 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 1.54E-06 0.20 rs10941073 49.09 logistic AGE:SEX Ml vs no Ml (at entry) 5 1.83E-06 0.15 rs10941073 49.09 logistic AGE:SEX Ml vs no Ml (follow-up) 5 3.39E-06 0.20 rs10941073 49.09 logistic GE:AGE:SEX Ml vs control (at entry) 5 1.20E-05 0.19 rs10941073 49.09 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 1.71 E-05 0.19 rs10941073 49.09 logistic GE:AGE:SEX Ml vs control (follow-up) 5 6.51 E-05 0.25 rs10941073 49.09 logistic Ml vs control (at entry) 5 7.21 E-05 0.19 rs10941073 49.09 logistic AGE:SEX Ml vs control (at entry) 5 8.72E-05 0.19 rs10941073 49.09 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 5 9.22E-05 0.25 rs10941073 49.09 logistic Ml vs control (follow-up) 5 0.0002651 0.25 rs10941073 49.09 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 0.0002779 0.19 rs10941073 49.09 logistic AGE:SEX Ml vs control (follow-up) 5 0.0003947 0.25 rs10942230 39.64 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0001943 0.80 rs10942230 39.64 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.0003672 0.80 rs10942230 39.64 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0004837 0.80 rs10951655 62.55 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 7 8.85E-05 1.43 rs10951655 62.55 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 7 0.0001329 1.46 rs10951655 62.55 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 0.0002059 1.43 rs10951655 62.55 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.0002757 1.31 rs10951655 62.55 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0002839 1.43 rs10951655 62.55 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 0.0004775 1.46 rs10952398 169.08 logistic GE:AGE:SEX Ml vs no Ml (at entry) 7 0.0002117 0.59 rs10952398 169.08 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 7 0.0003422 0.59 rs10952398 169.08 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0004275 0.59 rs10952398 169.08 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 7 0.0004299 0.59 rs10952398 169.08 logistic Ml vs no Ml (at entry) 7 0.0004569 0.59 rs10952429 169.44 logistic AGE:SEX Ml vs no Ml (at entry) 7 0.0002927 1.29 rs10955953 126.66 logistic AGE:SEX Ml vs no Ml (at entry) 8 7.37E-05 0.76 rs10955953 126.66 logistic Ml vs no Ml (at entry) 8 0.0001147 0.76 rs10955953 126.66 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0002545 0.78 rs10955953 126.66 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.000301 0.76 rs10955953 126.66 logistic Ml vs no Ml (follow-up) 8 0.0004134 0.78 rs10955953 126.66 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0004211 0.76 rs10956801 102.66 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 8.31 E-06 0.26

rs10956801 102.66 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 9.02E-06 0.26 rs10956801 102.66 logistic Ml vs no Ml (at entry) 8 9.80E-06 0.26 rs10956801 102.66 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 9.83E-06 0.26 rs10956801 102.66 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 1.14E-05 0.26 rs10956801 102.66 logistic AGE:SEX Ml vs no Ml (at entry) 8 2.28E-05 0.26 rs10956801 102.66 logistic Ml vs no Ml (follow-up) 8 9.96E-05 0.36 rs10956801 102.66 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0001066 0.36 rs10956801 102.66 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0001369 0.36 rs10956801 102.66 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 8 0.0001482 0.36 rs10956801 102.66 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0001652 0.36 rs10956801 102.66 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0002712 0.36 rs10959548 2.65 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0003603 0.81 rs10959548 2.65 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0004765 0.81 rs10960001 24.58 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 9 0.0004678 0.85 rs10960002 24.58 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 9 0.0004678 0.85 rs10964178 33.72 logistic AGE:SEX Ml vs no Ml (follow-up) 9 0.0002368 1.28 rs10964178 33.72 logistic Ml vs no Ml (follow-up) 9 0.0003807 1.28 rs10968433 50.97 logistic GE:AGE:SEX Ml vs control (at entry) 9 2.07E-05 1.42 rs10968433 50.97 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 9 3.09E-05 1.42 rs 10968433 50.97 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0001248 1.41 rs10968433 50.97 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 9 0.0001405 1.41 rs10968433 50.97 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 0.0001596 1.41 rs10968433 50.97 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 9 0.0002541 1.42 rs10968433 50.97 logistic AGEiSEX Ml vs control (at entry) 9 0.0002647 1.42 rs10968433 50.97 logistic Ml vs control (at entry) 9 0.0003215 1.42 rs10968434 50.97 logistic GE:AGE:SEX Ml vs control (at entry) 9 3.24E-05 1.40 rs10968434 50.97 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 9 4.97E-05 1.40 rs10968434 50.97 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 9 0.0001471 1.39 rs10968434 50.97 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0001809 1.39 rs10968434 50.97 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 0.0002358 1.39 rs10968434 50.97 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 9 0.0002631 1.40 rs10968434 50.97 logistic AGE:SEX Ml vs control (at entry) 9 0.0004529 1.40 rs10972699 59.07 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 9 0.0001351 0.72 rs10977348 18.98 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0003373 1.23 rs 10978784 102.44 logistic Ml vs control (follow-up) 9 0.0001978 0.60 rs10978784 102.44 logistic AGEiSEX Ml vs control (follow-up) 9 0.0003602 0.60

rs10978835 102.44 logistic Ml vs control (follow-up) 9 0.0001884 0.60 rs10978835 102.44 logistic AGE:SEX Ml vs control (follow-up) 9 0.0003302 0.60 rs10980446 117.92 logistic AGE:SEX Ml vs control (follow-up) 9 0.0001399 0.54 rs10980446 117.92 logistic Ml vs control (follow-up) 9 0.0001754 0.54 rs10980452 117.92 logistic AGE:SEX Ml vs control (follow-up) 9 0.000152 0.54 rs 10980452 117.92 logistic Ml vs control (follow-up) 9 0.0002094 0.54 rs10982428 122.99 logistic GE:AGE:SEX Ml vs no Ml (at entry) 9 4.32E-05 0.45 rs10982428 122.99 logistic Ml vs no Ml (at entry) 9 7.76E-05 0.45 rs10982428 122.99 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 9 9.30E-05 0.45 rs10982428 122.99 logistic AGE:SEX Ml vs no Ml (at entry) 9 0.0001222 0.45 rs10982428 122.99 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 9 0.0001595 0.45 rs10982428 122.99 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0004758 0.53 rs10989294 102.71 logistic AGE:SEX Ml vs control (follow-up) 9 2.35E-05 0.52 rs10989294 102.71 logistic Ml vs control (follow-up) 9 2.73E-05 0.52 rs 10989294 102.71 logistic Ml vs control (at entry) 9 0.0001251 0.57 rs10989294 102.71 logistic AGE:SEX Ml vs control (at entry) 9 0.0001495 0.57 rs10989294 102.71 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0003627 0.52 rs10991736 97.22 logistic Ml vs no Ml (follow-up) 9 0.0003568 1.44 rs10991736 97.22 logistic Ml vs no Ml (at entry) 9 0.000394 1.44 rs10991736 97.22 logistic AGE:SEX Ml vs no Ml (follow-up) 9 0.0004604 1.44 rs10991736 97.22 logistic AGE:SEX Ml vs no Ml (at entry) 9 0.000494 1.44 rs10991781 98.08 logistic AGE:SEX Ml vs control (follow-up) 9 0.0004365 0.63 rs10996473 81.90 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0002464 1.18 rs 10996473 81.90 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 0.0004361 1.16 rs10998910 89.35 logistic Ml vs control (at entry) 10 0.000341 1.41 rs10998910 89.35 logistic AGE:SEX Ml vs control (at entry) 10 0.0004907 1.41 rs11001683 96.61 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0004599 0.68 rs11010237 63.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 8.93E-06 1.33 rs11010237 63.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 5.29E-05 1.29 rs11010237 63.58 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0001855 1.33 rs11014137 49.51 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 5.97E-05 1.31 rs11014137 49.51 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 10 0.0002756 1.31 rs11018633 90.64 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 2.02E-06 0.26 rs11018633 90.64 logistic Ml vs no Ml (at entry) 11 2.39E-06 0.26 rs11018633 90.64 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 11 2.86E-06 0.26 rs11018633 90.64 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 11 3.04E-06 0.26

rs11018633 90.64 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 3.45E-06 0.26 rs11018633 90.64 logistic AGE:SEX Ml vs no Ml (at entry) 11 4.65E-06 0.26 rs11018633 90.64 logistic Ml vs no Ml (follow-up) 11 1.68E-05 0.34 rs11018633 90.64 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 11 1.87E-05 0.34 rs11018633 90.64 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 11 3.18E-05 0.34 rs11018633 90.64 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 11 3.18E-05 0.34 rs11018633 90.64 logistic HBP:GE:AGE:SEX Ml vs po Ml (follow-up) 11 3.53E-05 0.34 rs11018633 90.64 logistic AGE:SEX Ml vs no Ml (follow-up) 11 3.94E-05 0.34 rs11020082 91.90 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 11 0.0004694 1.10 rs11020878 92.56 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 11 0.0002989 0.63 rs11020878 92.56 logistic GE:AGE:SEX Ml vs control (at entry) 11 0.0003206 0.63 rs11020878 92.56 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 11 0.000414 0.60 rs11020878 92.56 logistic GE:AGE:SEX Ml vs control (follow-up) 11 0.0004484 0.60 rs11020878 92.56 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0004676 0.63 rs11044739 36.64 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 3.78E-05 1.45 rs11044739 36.64 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 9.82E-05 1.45 rs11044739 36.64 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.0001185 1.42 rs11044739 36.64 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0001523 1.45 rs11044739 36.64 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0001593 1.45 rs11044739 36.64 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0001883 1.42 rs11044739 36.64 logistic AGE:SEX Ml vs no Ml (at entry) 12 0.0001965 1.45 rs11044739 36.64 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.0002656 1.42 rs11044739 36.64 logistic Ml vs no Ml (at entry) 12 0.0002716 1.45 rs 11044739 36.64 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0002765 1.42 rs11044739 36.64 logistic AGE:SEX Ml vs no Ml (follow-up) 12 0.0003343 1.42 rs11044739 36.64 logistic Ml vs no Ml (follow-up) 12 0.0004848 1.42 rs11044750 36.66 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 0.0003133 1.43 rs11044750 36.66 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.0004842 1.41 rs11047424 43.68 logistic AGE:SEX Ml vs no Ml (follow-up) 12 0.0004265 0.77 rs11047424 43.68 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.0004513 0.77 rs11050429 50.72 logistic Ml vs control (at entry) 12 0.0004075 1.58 rs11054588 17.03 logistic AGE:SEX Ml vs control (follow-up) 12 1.72E-05 0.42 rs11054588 17.03 logistic GE:AGE:SEX Ml vs control (follow-up) 12 3.04E-05 0.42 rs11054588 17.03 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 3.56E-05 0.42 rs11054588 17.03 logistic Ml vs control (follow-up) 12 4.31 E-05 0.42 rs11054588 17.03 logistic AGE:SEX Ml vs control (at entry) 12 0.0001227 0.47

rs11054588 17.03 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0001426 0.42 rs11054588 17.03 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.0001591 0.47 rs11054588 17.03 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0002016 0.47 rs11054588 17.03 logistic Ml vs control (at entry) 12 0.000265 0.47 rs11054878 17.10 logistic AGE:SEX Ml vs control (follow-up) 12 2.84E-05 0.43 rs11054878 17.10 logistic GE:AGE:SEX Ml vs control (follow-up) 12 4.48E-05 0.43 rs11054878 17.10 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 5.52E-05 0.43 rs11054878 17.10 logistic Ml vs control (follow-up) 12 6.31 E-05 0.43 rs11054878 17.10 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0001459 0.43 rs11054878 17.10 logistic AGE:SEX Ml vs control (at entry) 12 0.0001955 0.48 rs11054878 17.10 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.0002339 0.48 rs11054878 17.10 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0003115 0.48 rs11054878 17.10 logistic Ml vs control (at entry) 12 0.0003897 0.48 rs11055699 30.78 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 6.58E-05 1.50 rs11055699 30.78 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 9.62E-05 1.49 rs11060924 163.69 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 8.94E-06 1.89 rs11060924 163.69 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 1.98E-05 1.83 rs11060924 163.69 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 2.83E-05 1.89 rs11060924 163.69 logistic AGE:SEX Ml vs no Ml (at entry) 12 4.14E-05 1.89 rs11060924 163.69 logistic Ml vs no Ml (at entry) 12 4.27E-05 1.89 rs11060924 163.69 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 6.14E-05 1.89 rs11060924 163.69 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 6.45E-05 1.83 rs11060924 163.69 logistic AGE:SEX Ml vs no Ml (follow-up) 12 8.83E-05 1.83 rs11060924 163.69 logistic Ml vs no Ml (follow-up) 12 9.39E-05 1.83 rs11060924 163.69 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.000133 1.83 rs11060924 163.69 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 12 0.0003185 1.74 rs11060924 163.69 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 0.000339 1.89 rs11065172 137.45 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.0001295 0.77 rs11065172 137.45 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0001598 0.77 rs11065172 137.45 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0001647 0.77 rs11065172 137.45 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.0001657 0.75 rs11065172 137.45 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.0001698 0.77 rs11065172 137.45 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0001935 0.75 rs11065172 137.45 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0002011 0.77 rs11065172 137.45 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 0.0002497 0.77 rs11066620 120.87 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0001549 1.26

rs11066620 120.87 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.0001814 1.25 rs11066620 120.87 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0002945 1.26 rs11066620 120.87 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0003373 1.25 rs11066620 120.87 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.000344 1.25 rs11066620 120.87 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0003451 1.26 rs11066620 120.87 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 0.0003658 1.26 rs11066620 120.87 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0004037 1.26 rs11066620 120.87 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0004273 1.25 rs11066633 120.88 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0001634 0.78 rs11066633 120.88 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0001717 0.79 rs11066633 120.88 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 0.0001833 0.77 rs11066633 120.88 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 0.0002086 0.78 rs11066633 120.88 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0002214 0.78 rs11066633 120.88 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.0003644 0.79 rs11066633 120.88 logistic GE:AGE:SEX Ml vs control (follow-up) 12 0.0004593 0.77 rs11066737 118.54 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 6.88E-05 0.79 rs11066737 118.54 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.000252 0.81 rs11066945 121.52 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 3.55E-07 0.20

OC rs11066945 121.52 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 7.30E-07 0.20 rs11066945 121.52 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 1.08E-06 0.20 rs11066945 121.52 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 1.15E-06 0.20 rs11066945 121.52 logistic Ml vs no Ml (at entry) 12 1.75E-06 0.20 rs11066945 121.52 logistic AGE:SEX Ml vs no Mi (at entry) 12 2.84E-06 0.20 rs11066945 121.52 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 5.22E-06 0.30 rs11066945 121.52 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 7.20E-06 0.30 rs11066945 121.52 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 1.17E-05 0.30 rs11066945 121.52 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 1.21 E-05 0.30 rs11066945 121.52 logistic Ml vs no Ml (follow-up) 12 1.34E-05 0.30 rs11066945 121.52 logistic AGE:SEX Ml vs ,no Ml (follow-up) 12 2.52E-05 0.30 rs11066945 121.52 logistic GE:AGE:SEX Ml vs control (at entry) 12 6.56E-05 0.27 rs11066945 121.52 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0001175 0.27 rs11066945 121.52 logistic AGE:SEX Ml vs control (at entry) 12 0.0004085 0.27 rs11066945 121.52 logistic Ml vs control (at entry) 12 0.0004236 0.27 rs11067030 118.58 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 4.38E-05 0.77 rs11067030 118.58 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.0001708 0.79 rs11067311 124.02 logistic GE:AGE:SEX Ml vs control (at entry) 12 9.65E-05 1.48

rs11067311 124.02 logistic AGE:SEX Ml vs control (at entry) 12 0.0001675 1.48 rs11067311 124.02 logistic GE:AGE:CRCL:SEX WII vs control (at entry) 12 0.0001691 1.48 rs11067311 124.02 logistic Ml vs control (at entry) 12 0.0002284 1.48 rs11071957 65.80 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 15 0.0003813 0.78 rs11079384 81.57 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 17 0.0003237 1.28 rs11087179 38.70 logistic Ml vs no Ml (at entry) 20 0.00026 0.70 rs11087179 38.70 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 20 0.0002638 0.70 rs11087179 38.70 logistic GE:AGE:SEX Ml vs no Ml (at entry) 20 0.0002868 0.70 rs11087179 38.70 logistic AGE:SEX Ml vs no Ml (at entry) 20 0.0003551 0.70 rs11097731 106.47 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 4 0.0004622 1.36 rs11103567 155.20 logistic AGEiSEX Ml vs control (follow-up) 9 0.0004411 0.72 rs11106325 95.72 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0001946 0.72 rs11108755 101.93 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 4.24E-05 1.30 rs11109070 102.52 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0003966 2.89 rs11111522 110.29 logistic AGEiSEX Ml vs no Ml (at entry) 12 0.0002198 0.57 rs11111522 110.29 logistic Ml vs no Ml (at entry) 12 0.0002304 0.57 rs11111522 110.29 logistic GEIAGEISEX Ml vs no Ml (at entry) 12 0.0002455 0.57 rs11111522 110.29 logistic AGEISEX Ml vs no Ml (follow-up) 12 0.0002497 0.58 rs11111522 110.29 logistic GEiAGEiCRCLiSEX Ml vs no Ml (at entry) 12 0.0002586 0.57 rs11111522 110.29 logistic Ml vs no Ml (follow-up) 12 0.0002654 0.58 rs11111522 110.29 logistic GEIAGEISEX Ml vs no Ml (follow-up) 12 0.0002734 0.58 rs11111522 110.29 logistic GEIAGEICRCLISEX Ml vs no Ml (follow-up) 12 0.0002894 0.58 rs11111522 110.29 logistic Ml vs control (at entry) 12 0.000334 0.52 rs11111522 110.29 logistic GEiAGEiACRiSEX Ml vs no Ml (follow-up) 12 0.0003619 0.58 rs11111522 110.29 logistic AGEiSEX Ml vs control (at entry) 12 0.0004133 0.52 rs11111522 110.29 logistic GEIAGEIACRISEX Ml vs no Ml (at entry) 12 0.0004896 0.57 rs11111535 110.33 logistic GEIAGEICRCLISEX Ml vs control (follow-up) 12 0.00047 0.54 rs11115007 91.02 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 12 0.0004916 1.27 rs11125644 77.27 logistic Ml vs no Ml (at entry) 2 4.24E-05 0.24 rs11125644 77.27 logistic GEIAGEISEX Ml vs no Ml (at entry) 2 5.38E-05 0.24 rs11125644 77.27 logistic GEIAGEICRCLISEX Ml vs no Ml (at entry) 2 6.81 E-05 0.24 rs11125644 77.27 logistic GEIAGEIACRISEX Ml vs no Ml (at entry) 2 6.95E-05 0.24 rs11125644 77.27 logistic AGEISEX Ml vs no Ml (at entry) 2 9.38E-05 0.24 rs11125644 77.27 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 2 0.000209 0.24 rs11125644 77.27 logistic Ml vs no Ml (follow-up) 2 0.0002514 0.33 rs11125644 77.27 logistic GEIAGEISEX Ml vs no Ml (follow-up) 2 0.0003953 0.33

rs1113323 138.10 logistic Ml vs no Ml (follow-up) 10 0.0002746 0.76 rs1113323 138.10 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0002798 0.76 rs1113323 138.10 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.0003218 0.76 rs1113323 138.10 logistic Ml vs no Ml (at entry) 10 0.0004316 0.77 rs1113323 138.10 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0004735 0.77 rs1113323 138.10 logistic AGE:SEX Ml vs no Ml (at entry) 10 0.0004993 0.77 rs11135724 46.70 logistic AGE:SEX Ml vs control (follow-up) 8 0.0002903 0.70 rs11142750 66.21 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 9 2.60E-05 1.55 rs11142750 66.21 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 9 7.26E-05 1.55 rs11142750 66.21 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 7.78E-05 1.55 rs11142750 66.21 logistic AGEiSEX Ml vs control (follow-up) 9 0.0001236 1.55 rs11142750 66.21 logistic Ml vs control (follow-up) 9 0.0002349 1.55 rs11142750 66.21 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0002492 1.55 rs11152968 103.35 logistic Ml vs no Ml (at entry) 6 2.67E-05 0.67 rs11152968 103.35 logistic AGE:SEX Ml vs no Ml (at entry) 6 4.47E-05 0.67 rs11152968 103.35 logistic Ml vs no Ml (follow-up) 6 6.95E-05 0.69 rs11152968 103.35 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 7.22E-05 0.67 rs11152968 103.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 9.01 E-05 0.67

O O rs11152968 103.35 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0001251 0.69 rs11152968 103.35 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001829 0.69 rs11152968 103.35 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0001938 0.67 rs11152968 103.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0002277 0.69 rs11152968 103.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0003654 0.67 rs11152968 103.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0003864 0.69 rs11153023 103.38 logistic Ml vs no Ml (at entry) 6 2.32E-05 0.67 rs11153023 103.38 logistic AGE:SEX Ml vs no Ml (at entry) 6 3.92E-05 0.67 rs11153023 103.38 logistic Ml vs no Ml (follow-up) 6 6.19E-05 0.69 rs11153023 103.38 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 6.27E-05 0.67 rs11153023 103.38 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 7.79E-05 0.67 rs11153023 103.38 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0001123 0.69 rs11153023 103.38 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001627 0.69 rs11153023 103.38 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0002011 0.67 rs11153023 103.38 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0002018 0.69 rs11153023 103.38 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0003183 0.67 rs11153023 103.38 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.000342 0.69 rs11153166 117.60 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.0002535 0.75

rs11153167 117.60 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.0002927 0.75 rs11157107 44.32 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 14 0.0001324 0.78 rs11160288 114.69 logistic Ml vs control (follow-up) 14 0.000247 0.69 rs11160288 114.69 logistic AGE:SEX Ml vs control (follow-up) 14 0.0004153 0.69 rs11160289 114.69 logistic Ml vs control (follow-up) 14 0.000247 0.69 rs11160289 114.69 logistic AGE:SEX Ml vs control (follow-up) 14 0.0004153 0.69 rs11163592 113.69 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 4.67E-05 0.31 rs11163592 113.69 logistic Ml vs no Ml (at entry) 1 5.43E-05 0.31 rs11163592 113.69 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 6.16E-05 0.31 rs11163592 113.69 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 7.39E-05 0.31 rs11163592 113.69 logistic AGE:SEX Ml vs no Ml (at entry) 1 0.0001105 0.31 rs11163592 113.69 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0001343 0.31 rs11163592 113.69 logistic Ml vs no Ml (follow-up) 1 0.000265 0.39 rs11163592 113.69 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0002705 0.39 rs11163592 113.69 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.0003548 0.39 rs11163592 113.69 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0003938 0.34 rs11163592 113.69 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 0.0004821 0.39

K. rs11167 15.95 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0002491 2.12

2 rs11170242 67.76 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.0004756 1.48 rs1117702 16.59 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 7 3.92E-05 1.32 rs1117702 16.59 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 4.68E-05 1.32 rs1117702 16.59 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 5.61 E-05 1.32 rs1117702 16.59 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 7.56E-05 1.32 rs1117702 16.59 logistic Ml vs no Ml (follow-up) 7 0.0002791 1.32 rs1117702 16.59 logistic AGE:SEX Ml vs no Ml (follow-up) 7 0.0003319 1.32 rs1117702 16.59 logistic GE:AGE:ACR:SEX Ml vs np Ml (at entry) 7 0.0003725 1.27 rs1117702 16.59 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 7 0.0004135 1.27 rs1117702 16.59 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 7 0.0004739 1.27 rs11183154 59.33 logistic AGEiSEX Ml vs control (at entry) 12 0.0004173 0.66 rs11189836 121.27 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 1.25E-06 0.14 rs11189836 121.27 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 1.62E-06 0.14 rs11189836 121.27 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 1.81 E-06 0.14 rs11189836 121.27 logistic Ml vs no Ml (at entry) 10 2.10E-06 0.14 rs11189836 121.27 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 2.13E-06 0.14 rs11189836 121.27 logistic AGE:SEX Ml vs no Ml (at entry) 10 3.84E-06 0.14 rs11189836 121.27 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 1.84E-05 0.27

rs11189836 121.27 logistic GE:AGE:SEX Ml vs control (at entry) 10 2.19E-05 0.17 rs11189836 121.27 logistic Ml vs no Ml (follow-up) 10 2.23E-05 0.27 rs11189836 121.27 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 2.93E-05 0.27 rs11189836 121.27 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 2.94E-05 0.27 rs11189836 121.27 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 4.44E-05 0.17 rs11189836 121.27 logistic AGE:SEX Ml vs no Ml (follow-up) 10 5.50E-05 0.27 rs11189836 121.27 logistic Ml vs control (at entry) 10 6.93E-05 0.17 rs11189836 121.27 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 6.99E-05 0.27 rs11189836 121.27 logistic AGE:SEX Ml vs control (at entry) 10 8.84E-05 0.17 rs11189836 121.27 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 10 0.0001848 0.17 rs11192739 126.43 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0003431 1.29 rs11195125 129.09 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 10 0.0001153 1.65 rs11195917 131.17 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 7.60E-05 1.30 rs11195917 131.17 logistic Ml vs no Ml (follow-up) 10 0.0001111 1.30 rs11195917 131.17 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0001225 1.30 rs11195917 131.17 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.0001467 1.30 rs11195917 131.17 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0001739 1.30 rs11195917 131.17 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 0.0002552 1.33

O K) rs11195917 131.17 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 10 0.000306 1.38 rs11195917 131.17 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0004379 1.30 rs11195917 131.17 logistic GE:AGE:SEX Ml vs control (follow-up) 10 0.0004806 1.38 rs11197169 134.65 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 1.68E-06 0.09 rs11197169 134.65 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 2.12E-06 0.09 rs11197169 134.65 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 2.13E-06 0.09 rs11197169 134.65 logistic Ml vs no Ml (at entry) 10 2.50E-06 0.09 rs11197169 134.65 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 2.85E-06 0.09 rs11197169 134.65 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 3.79E-06 0.20 rs11197169 134.65 logistic AGEiSEX Ml vs no Ml (at entry) 10 4.19E-06 0.09 rs11197169 134.65 logistic Ml vs no Ml (follow-up) 10 4.40E-06 0.20 rs11197169 134.65 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 5.36E-06 0.20 rs11197169 134.65 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 6.06E-06 0.20 rs11197169 134.65 logistic AGE:SEX Ml vs no Ml (follow-up) 10 1.06E-05 0.20 rs11197169 134.65 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 1.51 E-05 0.20 rs11197169 134.65 logistic GE:AGE:SEX Ml vs control (at entry) 10 3.24E-05 0.12 rs11197169 134.65 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 5.61 E-05 0.12 rs11197169 134.65 logistic AGE:SEX Ml vs control (at entry) 10 7.95E-05 0.12

rs11197169 134.65 logistic Ml vs control (at entry) 10 8.12E-05 0.12 rs11197169 134.65 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 10 0.0003291 0.12 rs11197169 134.65 logistic GE:AGE:SEX Ml vs control (follow-up) 10 0.0003491 0.25 rs11208923 99.31 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.000149 0.67 rs11208923 99.31 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 0.0001584 0.64 rs 11208923 99.31 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0001724 0.67 rs11208923 99.31 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.0001977 0.64 rs11208923 99.31 logistic AGE:SEX Ml vs control (at entry) 1 0.0004808 0.67 rs11208923 99.31 logistic AGE:SEX Ml vs control (follow-up) 1 0.0004815 0.64 rs11216740 113.30 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 11 2.43E-05 0.79 rs11216740 113.30 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0001369 0.81 rs11219434 122.81 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 0.0004723 1.27 rs11220561 127.83 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 11 0.0003144 0.67 rs11220561 127.83 logistic GE:AGE:SEX Ml vs control (at entry) 11 0.0003229 0.67 rs11221112 130.13 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0003818 1.23 rs11221126 130.21 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0004309 1.16 rs11225370 99.13 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 11 0.0001539 0.68 rs11225370 99.13 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0002687 0.70 rs11225370 99.13 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 0.0004345 0.68 rs11225370 99.13 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0004463 0.68 rs11225370 99.13 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 0.0004769 0.68 rs11225377 99.15 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 11 2.69E-05 0.63 rs11225377 99.15 logistic HBP:GE:AGE:SEX Ml vs no Mi (follow-up) 11 6.16E-05 0.65 rs11225377 99.15 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 6.21 E-05 0.63 rs11225377 99.15 logistic AGE:SEX Ml vs no Ml (at entry) 11 6.87E-05 0.63 rs11225377 99.15 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 8.16E-05 0.63 rs 11225377 99.15 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 11 0.0001227 0.65 rs11225377 99.15 logistic AGE:SEX Ml vs no Ml (follow-up) 11 0.0001359 0.65 rs11225377 99.15 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0001596 0.65 rs 11225377 99.15 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 11 0.0002122 0.63 rs11225377 99.15 logistic Ml vs no Ml (at entry) 11 0.0002153 0.63 rs 11225377 99.15 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 11 0.0004525 0.65 rs11225634 99.42 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0003304 1.41 rs11235074 89.29 logistic AGE:SEX Ml vs no Ml (follow-up) 11 9.64E-05 1.29 rs11235074 89.29 logistic AGE:SEX Ml vs control (at entry) 11 0.0001182 1.38 rs11235074 89.29 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0001299 1.29

rs11235074 89.29 logistic Ml vs no Ml (follow-up) 11 0.0001862 1.29 rs11235074 89.29 logistic Ml vs control (at entry) 11 0.0002067 1.38 rs11235074 89.29 logistic Ml vs no Ml (at entry) 11 0.0002235 1.29 rs11241892 132.45 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 5 0.0003672 0.83 rs11241892 132.45 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 5 0.0004312 0.82 rs11248591 145.95 logistic Ml vs no Ml (at entry) 10 0.000205 1.42 rs 11248591 145.95 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 0.0002217 1.42 rs11248591 145.95 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 0.000265 1.42 rs11248591 145.95 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 0.0002924 1.42 rs11248591 145.95 logistic Ml vs no Ml (follow-up) 10 0.0002975 1.41 rs11248591 145.95 logistic AGE:SEX Ml vs no Ml (at entry) 10 0.0003433 1.42 rs11248591 145.95 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 0.0003802 1.41 rs11248591 145.95 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0004454 1.41 rs11249885 14.51 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0004408 1.30 rs11254023 18.68 logistic AGE:SEX Ml vs no Ml (at entry) 10 7.57E-05 0.69 rs11254023 18.68 logistic Ml vs no Ml (at entry) 10 7.68E-05 0.69 rs11254023 18.68 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 9.12E-05 0.69

K. rs11254023 18.68 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0001312 0.69

2 rs11254023 18.68 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.0001761 0.71 rs11254023 18.68 logistic Ml vs no Ml (follow-up) 10 0.0001772 0.71 rs11254023 18.68 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.000185 0.71 rs11254023 18.68 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 0.0002172 0.69 rs11254023 18.68 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.000288 0.71 rs11254023 18.68 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 0.0004664 0.71 rs11254057 18.69 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 8.04E-05 0.72 rs11254057 18.69 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 9.92E-05 0.72 rs11254057 18.69 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 0.0001556 0.73 rs11254057 18.69 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 0.0001557 0.72 rs11254057 18.69 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0002441 0.73 rs11254057 18.69 logistic Ml vs no Ml (follow-up) 10 0.0002761 0.72 rs11254057 18.69 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.0002915 0.72 rs11254057 18.69 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 0.0003849 0.73 rs 11258652 35.24 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 10 0.0001106 1.32 rs11258652 35.24 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 0.0001859 1.32 rs11258827 35.66 logistic Ml vs no Ml (at entry) 10 0.0002967 0.66 rs11258827 35.66 logistic Ml vs no Ml (follow-up) 10 0.0003452 0.67

rs11258827 35.66 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0003765 0.66 rs11258827 35.66 logistic AGE:SEX Ml vs no Ml (at entry) 10 0.000465 0.66 rs11258827 35.66 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.000479 0.67 rs11258843 35.68 logistic Ml vs no Ml (at entry) 10 9.29E-05 0.63 rs11258843 35.68 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0001075 0.63 rs11258843 35.68 logistic AGE:SEX Ml vs no Ml (at entry) 10 0.0001377 0.63 rs11258843 35.68 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 0.0002379 0.63 rs11258843 35.68 logistic Ml vs no Ml (follow-up) 10 0.000282 0.66 rs11258843 35.68 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0003001 0.63 rs11258843 35.68 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 0.0003453 0.63 rs11258843 35.68 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0003689 0.66 rs11258843 35.68 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 0.0004201 0.63 rs11258843 35.68 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.00044 0.66 rs11259145 37.83 logistic Ml vs no Ml (at entry) 10 0.0001672 1.92 rs11259145 37.83 logistic GE:AGE:CRCLSEX Ml vs no Ml (at entry) 10 0.0002097 1.92 rs11259145 37.83 logistic AGE:SEX Ml vs no Ml (at entry) 10 0.0002177 1.92 rs11259145 37.83 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0002894 1.92 rs1154436 105.54 logistic AGEiSEX Ml vs control (follow-up) 4 9.19E-05 0.68

O rs1154436 105.54 logistic Ml vs control (follow-up) 4 0.0001212 0.68 rs1154436 105.54 logistic GE:AGE:SEX Ml vs control (follow-up) 4 0.0002234 0.68 rs1154436 105.54 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0002955 0.68 rs1157157 70.16 logistic AGE:SEX Ml vs control (at entry) 6 0.0001077 1.66 rs1157157 70.16 logistic GE:AGE:SEX Ml vs control (at entry) 6 0.0001239 1.66 rs1157157 70.16 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 6 0.0001261 1.66 rs1157157 70.16 logistic Ml vs control (at entry) 6 0.0001469 1.66 rs11577590 97.68 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 0.0001968 1.54 rs11580655 211.84 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 1 3.18E-05 1.81 rs11580655 211.84 logistic AGE:SEX Ml vs control (follow-up) 1 6.11 E-05 1.81 rs11580655 211.84 logistic Ml vs control (follow-up) 1 0.0001646 1.81 rs11580655 211.84 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 0.0002508 1.81 rs11580655 211.84 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.0003357 1.81 rs11589826 227.79 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 0.0004364 1.26 rs11595123 11.53 logistic AGE:SEX Ml vs control (follow-up) 10 0.000471 0.69 rs11595468 49.50 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0001062 1.26 rs11600876 129.14 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 11 0.00028 0.78 rs11600876 129.14 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.000324 0.78

rs11600876 129.14 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.000388 0.78 rs1160217 50.73 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 19 0.0001796 1.31 rs11615637 118.64 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 4.38E-05 0.76 rs11615637 118.64 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.0001708 0.79 rs11624722 51.49 logistic Ml vs control (follow-up) 14 8.86E-05 0.65 rs11624722 51.49 logistic AGEiSEX Ml vs control (follow-up) 14 0.0001094 0.65 rs11624722 51.49 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 14 0.0001692 0.65 rs11624722 51.49 logistic GE:AGE:SEX Ml vs control (follow-up) 14 0.0002137 0.65 rs11625370 26.40 logistic AGEiSEX Ml vs no Ml (at entry) 14 0.0004534 0.61 rs11648875 104.67 logistic AGEiSEX Ml vs control (follow-up) 16 0.0003555 1.71 rs11653885 94.51 logistic GEIAGEISEX Ml vs control (at entry) 17 0.0002495 0.78 rs11653885 94.51 logistic GEiAGEiCRCLiSEX Ml vs control (at entry) 17 0.0003525 0.78 rs11656181 53.27 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 17 0.0004317 1.25 rs11670955 67.89 logistic Ml vs control (follow-up) 19 0.0004472 1.41 rs11678867 230.10 logistic GEiAGEiACRiSEX Ml vs control (follow-up) 2 1.71 E-05 1.57 rs11678867 230.10 logistic HBPIGEIAGEISEX Ml vs control (follow-up) 2 2.54E-05 1.57 rs11678867 230.10 logistic HBPIGEIAGEISEX Ml vs control (at entry) 2 3.00E-05 1.50 rs11678867 230.10 logistic GEIAGEICRCLISEX Ml vs control (follow-up) 2 3.90E-05 1.57

O rs11678867 230.10 logistic GEIAGEIACRISEX Ml vs control (at entry) 2 3.96E-05 1.50 rs11678867 230.10 logistic GEIAGEISEX Ml vs control (follow-up) 2 4.35E-05 1.57 rs11678867 230.10 logistic GEIAGEICRCLISEX Ml vs control (at entry) 2 6.78E-05 1.50 rs11678867 230.10 logistic GEIAGEISEX Ml vs control (at entry) 2 8.16E-05 1.50 rs11678867 230.10 logistic AGEISEX Ml vs control (follow-up) 2 8.29E-05 1.57 rs11678867 230.10 logistic Ml vs control (follow-up) 2 8.55E-05 1.57 rs11678867 230.10 logistic Ml vs control (at entry) 2 9.00E-05 1.50 rs11678867 230.10 logistic AGEiSEX Ml vs control (at entry) 2 0.0001048 1.50 rs11688740 80.03 logistic AGEiSEX Ml vs control (at entry) 2 7.15E-05 1.49 rs11688740 80.03 logistic Ml vs control (at entry) 2 0.0001685 1.49 rs11691543 191.51 logistic GEIAGEIACRISEX Ml vs control (at entry) 2 0.0003528 1.34 rs11694629 131.02 logistic AGEISEX Ml vs control (at entry) 2 0.0003002 0.48 rs11697499 57.80 logistic HBPIGEIAGEISEX Ml vs control (at entry) 20 0.000212 1.15 rs11700793 7.48 logistic HBPIGEIAGEISEX Ml vs control (follow-up) 21 0.0001582 0.68 rs11700793 7.48 logistic HBPIGEIAGEISEX Ml vs control (at entry) 21 0.0002327 0.71 rs 11702528 7.50 logistic AGEISEX Ml vs control (follow-up) 21 0.0002245 0.67 rs11702528 7.50 logistic Ml vs control (follow-up) 21 0.0003456 0.67 rs11704699 4.04 logistic HBPIGEIAGEISEX Ml vs control (follow-up) 22 0.0002758 0.71

rs11705997 173.04 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0003344 0.68 rs11705997 173.04 logistic Ml vs no Ml (at entry) 3 0.0004023 0.68 rs11708432 125.57 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0004083 1.51 rs11708432 125.57 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 0.000427 1.51 rs11713100 125.57 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0003576 1.51 rs11713100 125.57 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 0.0003804 1.51 rs11734396 107.54 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0004736 1.32 rs11739158 76.84 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.0004279 0.80 rs11756315 103.39 logistic Ml vs no Ml (at entry) 6 9.13E-06 0.66 rs11756315 103.39 logistic AGE:SEX Ml vs no Ml (at entry) 6 1.40E-05 0.66 rs11756315 103.39 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 2.86E-05 0.66 rs11756315 103.39 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 3.21 E-05 0.66 rs11756315 103.39 logistic Ml vs no Ml (follow-up) 6 3.58E-05 0.68 rs11756315 103.39 logistic AGE:SEX Ml vs no Ml (follow-up) 6 5.80E-05 0.68 rs11756315 103.39 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001019 0.68 rs11756315 103.39 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0001151 0.68 rs11756315 103.39 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0001267 0.66 rs11756315 103.39 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0001381 0.66

O rs11756315 103.39 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0001794 0.68 rs11757063 103.34 logistic Ml vs no Ml (at entry) 6 2.67E-05 0.67 rs11757063 103.34 logistic AGE:SEX Ml vs no Ml (at entry) 6 4.47E-05 0.67 rs11757063 103.34 logistic Ml vs no Ml (follow-up) 6 6.95E-05 0.69 rs11757063 103.34 logistic GE:AGE:SEX Ml vs no Mi (at entry) 6 7.22E-05 0.67 rs11757063 103.34 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 9.01 E-05 0.67 rs11757063 103.34 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0001251 0.69 rs11757063 103.34 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001829 0.69 rs 11757063 103.34 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0001938 0.67 rs11757063 103.34 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0002277 0.69 rs11757063 103.34 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0003654 0.67 rs11757063 103.34 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0003864 0.69 rs11760007 89.44 logistic Ml vs control (at entry) 6 0.0002952 1.39 rs11760007 89.44 logistic GE:AGE:SEX Ml vs control (at entry) 6 0.0003168 1.39 rs11760007 89.44 logistic GE:AGE:CRCLSEX Ml vs control (at entry) 6 0.000377 1.39 rs11760007 89.44 logistic AGE:SEX Ml vs control (at entry) 6 0.0004045 1.39 rs11763010 122.15 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 0.0001247 0.78 rs11763010 122.15 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 0.0001886 0.78

rs11763010 122.15 logistic AGE:SEX Ml vs no Ml (follow-up) 7 0.0003408 0.78 rs11763010 122.15 logistic Ml vs no Ml (follow-up) 7 0.0003709 0.78 rs11763010 122.15 logistic GE:AGE:SEX Ml vs no Ml (at entry) 7 0.0004123 0.79 rs11763010 122.15 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.0004702 0.78 rs11771454 62.54 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.0003645 1.31 rs1177257 42.45 logistic AGEiSEX Ml vs control (follow-up) 14 0.0002254 0.70 rs11776270 26.89 logistic Ml vs no Ml (at entry) 8 4.95E-05 0.56 rs11776270 26.89 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 5.60E-05 0.56 rs11776270 26.89 logistic Ml vs no Ml (follow-up) 8 7.80E-05 0.58 rs11776270 26.89 logistic AGE:SEX Ml vs no Ml (at entry) 8 9.51 E-05 0.56 rs11776270 26.89 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0001041 0.58 rs11776270 26.89 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0001696 0.58 rs11776270 26.89 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0001948 0.56 rs 11776270 26.89 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0002884 0.58 rs11776270 26.89 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0002963 0.56 rs 11776270 26.89 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0003641 0.56 rs11776270 26.89 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0004551 0.58 rs11827218 12.85 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 11 0.0002871 0.71

O OO rs11827218 12.85 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0003017 0.71 rs11827218 12.85 logistic Ml vs no Ml (at entry) 11 0.0004188 0.71 rs11827218 12.85 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 0.000477 0.71 rs11843348 90.86 logistic GE:AGE:SEX Ml vs no Ml (at entry) 13 1.01 E-05 0.11 rs11843348 90.86 logistic HBP:GE:AGE:SEX Mi vs no Ml (at entry) 13 1.03E-05 0.11 rs11843348 90.86 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 13 1.18E-05 0.11 rs11843348 90.86 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 1.42E-05 0.11 rs11843348 90.86 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 13 1.47E-05 0.19 rs11843348 90.86 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 13 1.84E-05 0.19 rs11843348 90.86 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 13 2.01 E-05 0.19 rs11843348 90.86 logistic Ml vs no Ml (at entry) 13 2.02E-05 0.11 rs11843348 90.86 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 13 2.46E-05 0.19 rs11843348 90.86 logistic Ml vs no Ml (follow-up) 13 2.64E-05 0.19 rs11843348 90.86 logistic AGE:SEX Ml vs no Ml (at entry) 13 2.88E-05 0.11 rs11843348 90.86 logistic AGE:SEX Ml vs no Ml (follow-up) 13 4.59E-05 0.19 rs11843348 90.86 logistic GE:AGE:SEX Ml vs control (at entry) 13 0.0001365 0.14 rs11843348 90.86 logistic GE:AGE:SEX Ml vs control (follow-up) 13 0.0002149 0.22 rs11843348 90.86 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 13 0.0002205 0.14

rs11843348 90.86 logistic AGE:SEX Ml vs control (at entry) 13 0.0002812 0.14 rs11843348 90.86 logistic Ml vs control (at entry) 13 0.0003583 0.14 rs11843348 90.86 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 13 0.0004097 0.22 rs11843348 90.86 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 13 0.0004312 0.22 rs11843348 90.86 logistic AGE:SEX Ml vs control (follow-up) 13 0.0004499 0.22 rs11845632 89.22 logistic AGE:SEX Ml vs control (at entry) 14 0.0003629 1.33 rs11846532 109.33 logistic Ml vs control (at entry) 14 0.0001711 0.73 rs11846532 109.33 logistic AGEiSEX Ml vs control (at entry) 14 0.0002504 0.73 rs11846532 109.33 logistic GE:AGE:SEX Ml vs control (at entry) 14 0.0003372 0.73 rs11846532 109.33 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 14 0.0004109 0.73 rs11848645 37.87 logistic GE:AGE:SEX Ml vs control (at entry) 14 0.0003825 1.31 rs11850956 89.23 logistic AGE:SEX Ml vs control (at entry) 14 0.0002017 1.36 rs11850956 89.23 logistic AGE:SEX Ml vs control (follow-up) 14 0.0002614 1.37 rs11856921 36.31 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 15 0.0004835 1.32 rs1186143 41.44 logistic AGEiSEX Ml vs control (at entry) 13 0.0003085 2.39 rs11862589 74.00 logistic AGEiSEX Ml vs control (follow-up) 16 0.0004187 1.39 rs1186919 159.75 logistic HBPIGEIAGEISEX Ml vs control (follow-up) 5 0.0002055 1.28 rs11869607 71.43 logistic HBPIGEIAGEISEX Ml vs control (follow-up) 17 0.0001001 1.48

O rs11872825 81.97 logistic AGEiSEX Ml vs no Ml (follow-up) 18 0.0001181 1.30 rs11872825 81.97 logistic GEiAGEiCRCLiSEX Ml vs no Ml (follow-up) 18 0.0001348 1.30 rs11872825 81.97 logistic Ml vs no Ml (follow-up) 18 0.0001384 1.30 rs11872825 81.97 logistic GEIAGEISEX Ml vs no Ml (follow-up) 18 0.0001799 1.30 rs11931702 39.83 logistic GEIAGEISEX Ml vs control (at entry) 4 0.0004872 1.37 rs1193496 66.15 logistic AGEISEX . Ml vs control (follow-up) 11 6.48E-05 1.42 rs1193496 66.15 logistic Ml vs control (follow-up) 11 0.0001315 1,42 rs1193496 66.15 logistic AGEiSEX Ml vs no Ml (at entry) 11 0.0003054 1.27 rs1193496 66.15 logistic GEiAGEiACRiSEX Ml vs control (follow-up) 11 0.0003309 1.42 rs1193496 66.15 logistic AGEiSEX Ml vs control (at entry) 11 0.0004711 1.33 rs11941453 72.91 logistic HBPIGEIAGEISEX Ml vs control (follow-up) 4 0.000407 0.66 rs11941453 72.91 logistic GEIAGEIACRISEX Ml vs control (follow-up) 4 0.0004865 0.66 rs11951359 68.68 logistic AGEISEX Ml vs control (at entry) 5 0.0001736 0.64 rs11951359 68.68 logistic Ml vs control (at entry) 5 0.0001786 0.64 rs11966463 38.18 logistic AGEiSEX Ml vs control (at entry) 6 0.0002394 1.91 rs11966463 38.18 logistic Ml vs control (at entry) 6 0.0004273 1.91 rs11966463 38.18 logistic AGEiSEX Ml vs no Ml (at entry) 6 0.0004979 1.56 rs11973145 78.51 logistic GEIAGEICRCLISEX Ml vs no Ml (follow-up) 7 0.0003463 1.27

rs11973145 78.51 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.000394 1.27 rs12002851 99.54 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 9 3.11 E-05 1.95 rs12002851 99.54 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 9 4.20E-05 2.06 rs12002851 99.54 logistic Ml vs control (at entry) 9 0.0001004 1.95 rs12002851 99.54 logistic AGE:SEX Ml vs control (at entry) 9 0.0001408 1.95 rs12002851 99.54 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 9 0.0001707 1.95 rs12002851 99.54 logistic Ml vs control (follow-up) 9 0.0001979 2.06 rs12002851 99.54 logistic AGE:SEX Ml vs control (follow-up) 9 0.0002614 2.06 rs12002851 99.54 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 9 0.0002962 1.95 rs12002851 99.54 logistic GE:AGE:SEX Ml vs control (at entry) 9 0.0003128 1.95 rs12002851 99.54 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 9 0.0003192 2.06 rs12002851 99.54 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 0.0003729 2.06 rs12021074 87.56 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 13 1.06E-05 1.43 rs12021074 87.56 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 13 0.0001747 1.44 rs1202761 85.97 logistic Ml vs no Ml (follow-up) 1 0.000144 1.79 rs1202761 85.97 logistic AGE:SEX Ml vs no Ml (follow-up) 1 0.0002131 1.79 rs1202761 85.97 logistic Ml vs no Ml (at entry) 1 0.0004136 1.72 _w rs1202761 85.97 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0004984 1.79

S rs12032691 99.31 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0001541 0.67 rs12032691 99.31 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 0.0001639 0.64 rs12032691 99.31 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0001816 0.67 rs12032691 99.31 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.0002079 0.64 rs12042555 8.85 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 4.72E-05 3.01 rs12043406 8.85 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 8.39E-05 2.58 rs12043606 8.86 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 7.21 E-05 3.18 rs12046579 8.86 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.0002442 2.46 rs12049347 99.31 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 0.00021 0.64 rs12049347 99.31 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.0002624 0.64 rs12049347 99.31 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0003096 0.67 rs12049347 99.31 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.000329 0.67 rs12052971 252.56 logistic Ml vs no Ml (follow-up) 2 0.0003575 1.31 rs12052971 252.56 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0003802 1.31 rs12052971 252.56 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0004086 1.31 rs12097383 183.37 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 0.0004707 0.61 rs12123182 239.99 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0004464 0.77 rs12123182 239.99 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0004714 0.77

rs12131306 99.31 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0001895 0.67 rs12131306 99.31 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0002116 0.67 rs12131306 99.31 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 0.0002237 0.65 rs12131306 99.31 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.0002749 0.65 rs121317 80.69 logistic AGEiSEX Ml vs control (follow-up) 18 0.0003845 0.63 rs12131909 99.30 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 4.85E-05 0.65 rs12131909 99.30 logistic GE:AGE:SEX Ml vs control (at entry) 1 6.69E-05 0.65 rs12131909 99.30 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 8.57E-05 0.63 rs12131909 99.30 logistic AGE:SEX Ml vs control (at entry) 1 0.000126 0.65 rs12131909 99.30 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.0001296 0.63 rs12131909 99.30 logistic AGEiSEX Ml vs control (follow-up) 1 0.0002219 0.63 rs12131909 99.30 logistic Ml vs control (at entry) 1 ,0.0002755 0.65 rs12131909 99.30 logistic Ml vs control (follow-up) 1 0.0003733 0.63 rs12145301 102.01 logistic GEiAGEiCRCLiSEX Ml vs no Ml (at entry) 1 0.0001047 0.76 rs12145301 102.01 logistic GEIAGEISEX Ml vs no Ml (at entry) 1 0.0001065 0.76 rs12145301 102.01 logistic GEiAGEiACRiSEX Ml vs no Ml (at entry) 1 0.0001142 0.76 rs12145301 102.01 logistic GEIAGEICRCLISEX Ml vs no Ml (follow-up) 1 0.0002362 0.77 rs12145301 102.01 logistic GEIAGEISEX Ml vs no Ml (follow-up) 1 0.0002443 0.77 rs12145301 102.01 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 1 0.0002987 0.76 rs12145301 102.01 logistic Ml vs no Ml (at entry) 1 0.0003314 0.76 rs12145301 102.01 logistic GEIAGEIACRISEX Ml vs no Ml (follow-up) 1 0.000414 0.77 rs12147614 89.20 logistic AGEISEX Ml vs control (follow-up) 14 0.0001454 0.59 rs12147614 89.20 logistic Ml vs control (follow-up) 14 0.0001494 0.59 rs12147614 89.20 logistic GEIAGEIACRISEX Ml vs control (follow-up) 14 0.0002149 0.59 rs12154282 122.15 logistic GEIAGEISEX Ml vs no Ml (follow-up) 7 0.0002514 0.78 rs12154282 122.15 logistic GEIAGEICRCLISEX Ml vs no Mi (follow-up) 7 0.0003634 0.78 rs12161700 89.35 logistic Ml vs control (at entry) 10 0.000341 1.41 rs12161700 89.35 logistic AGEISEX Ml vs control (at entry) 10 0.0004907 1.41 rs1217580 80.71 logistic GEIAGEIACRISEX Ml vs no Ml (at entry) 18 4.82E-05 0.48 rs1217580 80.71 logistic GEIAGEICRCLISEX Ml vs no Ml (at entry) 18 6.26E-05 0.48 rs1217580 80.71 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 18 7.40E-05 0.48 rs1217580 80.71 logistic GEIAGEISEX Ml vs no Ml (at entry) 18 0.0001259 0.48 rs1217580 80.71 logistic AGEISEX Ml vs no Ml (at entry) 18 0.0001537 0.48 rs1217580 80.71 logistic Ml vs no Ml (at entry) 18 0.0001782 0.48 rs1217580 80.71 logistic GEIAGEIACRISEX Ml vs no Ml (follow-up) 18 0.0002934 0.54 rs1217580 80.71 logistic GEIAGEICRCLISEX Ml vs no Ml (follow-up) 18 0.0003312 0.54

rs1217580 80.71 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0004407 0.54 rs12186753 54.56 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 0.0003119 0.77 rs12207570 103.38 logistic Ml vs no Ml (at entry) 6 6.62E-06 0.65 rs12207570 103.38 logistic AGE:SEX Ml vs no Ml (at entry) 6 1.06E-05 0.65 rs12207570 103.38 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 2.11 E-05 0.65 rs12207570 103.38 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 2.39E-05 0.65 rs12207570 103.38 logistic Ml vs no Ml (follow-up) 6 2.54E-05 0.68 rs12207570 103.38 logistic AGE:SEX Ml vs no Ml (follow-up) 6 4.33E-05 0.68 rs12207570 103.38 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 7.44E-05 0.68 rs12207570 103.38 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 7.51 E-05 0.65 rs12207570 103.38 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 8.48E-05 0.68 rs12207570 103.38 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.000101 0.65 rs12207570 103.38 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0001388 0.68 rs12207570 103.38 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0002759 0.68 rs12208449 103.35 logistic Ml vs no Ml (at entry) 6 2.67E-05 0.67 rs 12208449 103.35 logistic AGE:SEX Ml vs no Ml (at entry) 6 4.47E-05 0.67 rs12208449 103.35 logistic Ml vs no Ml (follow-up) 6 6.95E-05 0.69

^ rs12208449 103.35 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 7.22E-05 0.67

G rs12208449 103.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 9.01 E-05 0.67 rs12208449 103.35 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0001251 0.69 rs12208449 103.35 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001829 0.69 rs12208449 103.35 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0001938 0.67 rs12208449 103.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0002277 0.69 rs12208449 103.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0003654 0.67 rs12208449 103.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0003864 0.69 rs12208556 103.35 logistic Ml vs no Ml (at entry) 6 6.85E-05 0.69 rs12208556 103.35 logistic AGEiSEX Ml vs no Ml (at entry) 6 0.00012 0.69 rs12208556 103.35 logistic Ml vs no Ml (follow-up) 6 0.0001536 0.71 rs12208556 103.35 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0002118 0.69 rs12208556 103.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 0.0002681 0.69 rs12208556 103.35 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0002918 0.71 rs12208556 103.35 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0004607 0.71 rs12208556 103.35 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0004748 0.69 rs12210146 103.35 logistic Ml vs no Ml (at entry) 6 2.67E-05 0.67 rs12210146 103.35 logistic AGE:SEX Ml vs no Ml (at entry) 6 4.47E-05 0.67 rs12210146 103.35 logistic Ml vs no Ml (follow-up) 6 6.95E-05 0.69

rs12210146 103.35 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 7.22E-05 0.67 rs12210146 103.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 9.01 E-05 0.67 rs12210146 103.35 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0001251 0.69 rs12210146 103.35 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001829 0.69 rs12210146 103.35 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0001938 0.67 rs12210146 103.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0002277 0.69 rs12210146 103.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0003654 0.67 rs12210146 103.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0003864 0.69 rs12213375 103.35 logistic Ml vs no Ml (at entry) 6 3.57E-05 0.68 rs12213375 103.35 logistic AGEiSEX Ml vs no Ml (at entry) 6 5.99E-05 0.68 rs12213375 103.35 logistic Ml vs no Ml (follow-up) 6 9.06E-05 0.70 rs12213375 103.35 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 9.68E-05 0.68 rs12213375 103.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 0.0001188 0.68 rs12213375 103.35 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0001636 0.70 rs12213375 103.35 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0002391 0.70 rs12213375 103.35 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0002458 0.68 rs12213375 103.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0002928 0.70 _w rs12213375 103.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0004804 0.68

C rs12220888 69.38 logistic AGE:SEX Ml vs control (follow-up) 10 0.0003909 3.64 rs12227177 110.39 logistic Ml vs control (at entry) 12 0.000346 0.53 rs12227177 110.39 logistic AGE:SEX Ml vs control (at entry) 12 0.000428 0.53 rs12227177 110.39 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0004513 0.53 rs12227177 110.39 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.000496 0.53 rs1224096 97.51 logistic AGE:SEX Ml vs control (follow-up) 13 9.07E-05 0.70 rs1224096 97.51 logistic GE:AGE:SEX Ml vs control (follow-up) 13 0.0001461 0.70 rs1224096 97.51 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 13 0.0001759 0.70 rs1224096 97.51 logistic Ml vs control (follow-up) 13 0.0002195 0.70 rs12245107 110.72 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0004102 1.20 rs12271990 32.19 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 6.26E-06 0.35 rs12271990 32.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 7.26E-06 0.35 rs12271990 32.19 logistic Ml vs no Ml (at entry) 11 1.10E-05 0.35 rs12271990 32.19 logistic AGE:SEX Ml vs no Ml (at entry) 11 1.48E-05 0.35 rs12271990 32.19 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 11 2.02E-05 0.35 rs12271990 32.19 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 11 5.96E-05 0.35 rs12271990 32.19 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0001489 0.45 rs12271990 32.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 11 0.0001718 0.45

rs12271990 32.19 logistic Ml vs no Ml (follow-up) 11 0.0002242 0.45 rs12271990 32.19 logistic AGEiSEX Ml vs no Ml (follow-up) 11 0.0003138 0.45 rs12271990 32.19 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 11 0.0004931 0.45 rs1229979 105.52 logistic AGE:SEX Ml vs control (follow-up) 4 0.0001242 0.68 rs1229979 105.52 logistic Ml vs control (follow-up) 4 0.0001563 0.68 rs1229979 105.52 logistic GE:AGE:SEX Ml vs control (follow-up) 4 0.0002777 0.68 rs1229979 105.52 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0003288 0.68 rs12307841 71.53 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.0003034 1.32 rs12329306 19.49 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 6.92E-05 1.34 rs1234805 54.09 logistic AGE:SEX Ml vs no Ml (at entry) 15 0.0001612 1.31 rs1234805 54.09 logistic Ml vs no Ml (at entry) 15 0.0001723 1.31 rs1234805 54.09 logistic AGE;SEX Ml vs no Ml (follow-up) 15 0.000386 1.29 rs 1234805 54.09 logistic Ml vs no Ml (follow-up) 15 0.0004187 1.29 rs12413650 160.05 logistic Ml vs control (at entry) 10 4.74E-05 0.62 rs12413650 160.05 logistic AGEiSEX Ml vs control (at entry) 10 4.78E-05 0.62 rs12413650 160.05 logistic AGE:SEX Ml vs control (follow-up) 10 0.0001391 0.62 rs12413650 160.05 logistic Ml vs control (follow-up) 10 0.000178 0.62 rs12413650 160.05 logistic GE:AGE:SEX Ml vs control (at entry) 10 0.0002569 0.62 rs12413650 160.05 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 0.0003765 0.62 rs12413650 160.05 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.0004754 0.72 rs12413650 160.05 logistic AGE:SEX Ml vs no Ml (at entry) 10 0.0004833 0.71 rs12420058 67.74 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0001828 1.28 rs12420058 67.74 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 11 0.0003648 1.36 rs12427691 49.92 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 1.71 E-07 0.47 rs12427691 49.92 logistic Ml vs no Ml (at entry) 13 1.88E-07 0.47 rs 12427691 49.92 logistic GE:AGE:SEX Ml vs no Ml (at entry) 13 1.97E-07 0.47 rs12427691 49.92 logistic AGE:SEX Ml vs no Ml (at entry) 13 2.68E-07 0.47 rs12427691 49.92 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 13 4.07E-07 0.47 rs12427691 49.92 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 13 5.13E-07 0.47 rs12427691 49.92 logistic Ml vs no Ml (follow-up) 13 1.63E-06 0.51 rs12427691 49.92 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 13 1.73E-06 0.51 rs12427691 49.92 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 13 2.06E-06 0.51 rs12427691 49.92 logistic AGE:SEX Ml vs no Ml (follow-up) 13 2.42E-06 0.51 rs12427691 49.92 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 13 3.35E-06 0.51 rs12427691 49.92 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 13 5.64E-06 0.51 rs12427691 49.92 logistic AGE:SEX Ml vs control (at entry) 13 0.0004002 0.55

rs 12427691 49.92 logistic GE:AGE:SEX Ml vs control (at entry) 13 0.0004735 0.55 rs12428162 97.45 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 13 9.30E-05 1.32 rs12428162 97.45 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 0.0001707 1.32 rs12428162 97.45 logistic AGE:SEX Ml vs no Ml (at entry) 13 0.0002891 1.32 rs12442570 6.20 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 15 0.0002813 1.42 rs12442570 6.20 logistic Ml vs no Ml (follow-up) 15 0.0003994 1.42 rs12442570 6.20 logistic AGE:SEX Ml vs no Ml (follow-up) 15 0.0004528 1.42 rs12443955 73.99 logistic Ml vs control (follow-up) 16 0.0001514 0.69 rs12443955 73.99 logistic AGE:SEX Ml vs control (follow-up) 16 0.0002187 0.69 rs12447906 128.25 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 16 0.0002112 0.75 rs12452883 90.03 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 17 2.68E-06 0.46 rs12452883 90.03 logistic Ml vs no Ml (at entry) 17 5.91 E-06 0.46 rs12452883 90.03 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 17 6.20E-06 0.46 rs12452883 90.03 logistic GE:AGE:SEX Ml vs no Ml (at entry) 17 7.78E-06 0.46 rs12452883 90.03 logistic AGE:SEX Ml vs no Ml (at entry) 17 8.50E-06 0.46 rs12452883 90.03 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 17 2.84E-05 0.51 rs12452883 90.03 logistic Ml vs no Ml (follow-up) 17 4.64E-05 0.51 _w rs12452883 90.03 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 17 5.13E-05 0.51

£ rs12452883 90.03 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 17 6.30E-05 0.51 rs12452883 90.03 logistic AGE:SEX Ml vs no Ml (follow-up) 17 7.07E-05 0.51 rs12452883 90.03 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 17 0.0001517 0.46 rs12458118 76.88 logistic Ml vs control (follow-up) 18 5.49E-05 0.69 rs12458118 76.88 logistic AGE:SEX Ml vs control (follow-up) 18 5.97E-05 0.69 rs12460612 99.73 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 19 0.0004666 0.60 rs12465363 256.67 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0004153 0.78 rs12472797 27.81 logistic AGE:SEX Ml vs control (follow-up) 2 0.0001975 0.70 rs12472797 27.81 logistic Ml vs control (follow-up) 2 0.0002337 0.70 rs12472797 27.81 logistic GE:AGE:SEX Ml vs control (follow-up) 2 0.0002839 0.70 rs12488732 105.19 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0003825 1.30 rs12503170 181.72 logistic AGE:SEX Ml vs control (follow-up) 4 0.0002422 1.68 rs12503170 181.72 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0003318 1.68 rs12503170 181.72 logistic Ml vs control (follow-up) 4 0.0004663 1.68 rs12503170 181.72 logistic GE:AGE:SEX Ml vs control (follow-up) 4 0.0004919 1.68 rs12505447 129.54 logistic Ml vs control (follow-up) 4 9.63E-05 0.63 rs12505447 129.54 logistic AGE:SEX Ml vs control (follow-up) 4 0.0001856 0.63 rs12505447 129.54 logistic GE:AGE:SEX Ml vs control (follow-up) 4 0.0003619 0.63

rs12509242 112.10 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0003705 0.76 rs12521059 17.83 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.000367 0.78 rs12530533 100.14 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 7 8.05E-05 0.39 rs12530533 100.14 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 7 8.44E-05 0.39 rs12530533 100.14 logistic GE:AGE:SEX Ml vs no Ml (at entry) 7 0.0001186 0.39 rs12530533 100.14 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 7 0.0001735 0.39 rs12530533 100.14 logistic Ml vs no Ml (at entry) 7 0.0001925 0.39 rs12530533 100.14 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 7 0.0002498 0.42 rs12530533 100.14 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0003784 0.42 rs12530533 100.14 logistic AGE:SEX Ml vs no Ml (at entry) 7 0.0004473 0.39 rs12530533 100.14 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.0004675 0.45 rs12531431 98.38 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 7 0.0004991 1.37 rs12536448 28.89 logistic GE:AGE:SEX Ml vs control (follow-up) 7 0.0003473 0.71 rs12536448 28.89 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 7 0.0004035 0.71 rs12536448 28.89 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 0.0004809 0.71 rs12536742 107.49 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 7 0.0002911 0.77 rs12536742 107.49 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0003085 0.77

^ rs12539892 16.59 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 7 4.14E-05 1.32

S rs12539892 16.59 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 5.18E-05 1.32 rs12539892 16.59 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 5.39E-05 1.32 rs12539892 16.59 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 7.42E-05 1.32 rs12539892 16.59 logistic Ml vs no Ml (follow-up) 7 0.0002699 1.32 rs12539892 16.59 logistic AGE:SEX Ml vs no Ml (follow-up) 7 0.0003282 1.32 rs12539892 16.59 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 7 0.0004136 1.27 rs12539892 16.59 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 7 0.0004394 1.27 rs12539892 16.59 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 7 0.0004625 1.27 rs1254531 66.94 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 10 0.0004978 0.67 rs12546625 126.69 logistic AGE:SEX Ml vs no Ml (at entry) 8 0.0004284 0.78 rs12552979 2.65 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0004897 0.80 rs12570123 112.46 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 0.0001377 1.58 rs12575085 36.09 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 11 6.60E-05 0.83 rs12575085 36.09 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 11 0.0001401 0.85 rs 12580234 93.09 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0001679 0.77 rs12580234 93.09 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.000279 0.77 rs12580234 93.09 logistic AGE:SEX Ml vs no Ml (follow-up) 12 0.0003695 0.77 rs12580234 93.09 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0004369 0.77

rs1259457 137.01 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 3 0.0003639 1.59 rs1259457 137.01 logistic HBP:GE:AGE:SEX Ml vs control (foflow-up) 3 0.0004868 1.59 rs12595945 65.15 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 16 0.0003857 0.69 rs12606388 114.85 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 5.44E-05 1.38 rs12606388 114.85 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 6.21 E-05 1.38 rs12606388 114.85 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 8.18E-05 1.38 rs12606388 114.85 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0001013 1.36 rs12606388 114.85 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0001108 1.36 rs12606388 114.85 logistic Ml vs no Ml (follow-up) 18 0.0001392 1.38 rs12606388 114.85 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0001413 1.38 rs12606388 114.85 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0001512 1.36 rs12606388 114.85 logistic AGE:SEX Ml vs no Ml (follow-up) 18 0.0001537 1.38 rs12606388 114.85 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0002585 1.36 rs12606388 114.85 logistic Ml vs no Ml (at entry) 18 0.0002899 1.36 rs12606388 114.85 logistic AGE:SEX Ml vs no Ml (at entry) 18 0.000322 1.36 rs12614381 145.69 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0004938 0.75 rs12620263 115.60 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.000219 1.37

^ rs12622278 33.78 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 1.32E-05 0.29

^ rs12622278 33.78 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 1.52E-05 0.29 rs12622278 33.78 logistic Ml vs no Ml (at entry) 2 1.56E-05 0.29 rs12622278 33.78 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 3.39E-05 0.29 rs12622278 33.78 logistic AGEiSEX Ml vs no Ml (at entry) 2 3.44E-05 0.29 rs12622278 33.78 logistic HBP:GE:AGE:SEX Ml vs no Mi (at entry) 2 0.0001152 0.29 rs12622278 33.78 logistic GE:AGE:SEX Ml vs control (at entry) 2 0.000291 0.32 rs12622278 33.78 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0003085 0.32 rs12622278 33.78 logistic Ml vs control (at entry) 2 0.0003434 0.32 rs12622278 33.78 logistic AGEiSEX Ml vs control (at entry) 2 0.0004427 0.32 rs12622278 33.78 logistic Ml vs no Ml (follow-up) 2 0.0004458 0.42 rs12634945 125.56 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.000187 1.55 rs12634945 125.56 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 0.0002009 1.55 rs 12634945 125.56 logistic AGEiSEX Ml vs no Ml (follow-up) 3 0.0003155 1.55 rs12634945 125.56 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0004476 1.51 rs12634945 125.56 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 0.0004544 1.55 rs12634945 125.56 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0004757 1.51 rs12657171 68.69 logistic Ml vs control (at entry) 5 9.72E-06 0.45 rs12657171 68.69 logistic AGE:SEX Ml vs control (at entry) 5 1.26E-05 0.45

rs12657171 68.69 logistic Ml vs control (follow-up) 5 7.52E-05 0.48 rs12657171 68.69 logistic AGE:SEX Ml vs no Ml (at entry) 5 9.58E-05 0.55 rs12657171 68.69 logistic AGE:SEX Ml vs control (follow-up) 5 0.0001018 0.48 rs12657171 68.69 logistic Ml vs no Ml (at entry) 5 0.0001582 0.55 rs12657171 68.69 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.0001845 0.58 rs12657171 68.69 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0001873 0.55 rs12657171 68.69 logistic GE:AGE:SEX Ml vs control (at entry) 5 0.0001986 0.45 rs12657171 68.69 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 0.000255 0.45 rs12657171 68.69 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0002922 0.55 rs12657171 68.69 logistic Ml vs no Ml (follow-up) 5 0.00033 0.58 rs12657171 68.69 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0003349 0.58 rs12669859 78.51 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.00037 1.26 rs12669859 78.51 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 0.0004718 1.26 rs12674699 53.21 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 8 0.0002189 0.74 rs 12679360 14.52 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0002866 1.31 rs12679360 14.52 logistic Ml vs no Ml (follow-up) 8 0.0004827 1.31 rs12681298 14.52 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0003456 1.30 _w rs12695902 164.90 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 3 5.50E-05 0.69

£ rs12716433 165.41 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.0004062 0.72 rs12726588 99.32 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0003019 0.69 rs12726588 99.32 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.000324 0.69 rs12726588 99.32 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 0.0004184 0.67 rs12750223 99.30 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 2.66E-07 0.52 rs12750223 99.30 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 5.39E-07 0.56 rs12750223 99.30 logistic GE:AGE:SEX Ml vs control (follow-up) 1 6.19E-07 0.52 rs12750223 99.30 logistic GE:AGE:SEX Ml vs control (at entry) 1 1.12E-06 0.56 rs12750223 99.30 logistic AGE:SEX Ml vs control (follow-up) ^• 1 1.24E-06 0.52 rs12750223 99.30 logistic Ml vs control (follow-up) 1 1.84E-06 0.52 rs12750223 99.30 logistic AGE:SEX Ml vs control (at entry) 1 2.57E-06 0.56 rs12750223 99.30 logistic Ml vs control (at entry) 1 5.54E-06 0.56 rs12750223 99.30 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 2.40E-05 0.52 rs12750223 99.30 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 8.45E-05 0.56 rs12750223 99.30 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.0001545 0.67 rs12750223 99.30 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0002635 0.67 rs12750223 99.30 logistic AGE:SEX Ml vs no Ml (follow-up) 1 0.0003077 0.67 rs12750223 99.30 logistic Ml vs no Ml (follow-up) 1 0.0003129 0.67

rs12779831 112.06 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 10 0.0002842 1.13 rs12802285 92.05 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0002104 1.25 rs1280680 130.99 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0003251 1.32 rs1280680 130.99 logistic Ml vs no Ml (follow-up) 4 0.0003406 1.32 rs1280680 130.99 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0003719 1.32 rs1280680 130.99 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0003829 1.32 rs1280680 130.99 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.000392 1.32 rs1280680 130.99 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.000407 1.32 rs1280680 130.99 logistic AGE:SEX Ml vs control (at entry) 4 0.0004322 1.41 rs1280680 130.99 logistic Ml vs control (at entry) 4 0.0004736 1.41 rs12814669 93.67 logistic AGEiSEX Ml vs control (at entry) 12 0.0001395 0.70 rs12814669 93.67 logistic Ml vs control (at entry) 12 0.0001464 0.70 rs12814669 93.67 logistic Ml vs control (follow-up) 12 0.0002594 0.69 rs12814669 93.67 logistic AGE:SEX Ml vs control (follow-up) 12 0.0003069 0.69 rs12896523 47.97 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 14 0.0004857 1.28 rs12907914 36.36 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 15 0.0003498 1.33 rs12937300 45.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 17 0.0001653 0.80

_K , rs12954795 107.89 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0001027 1.37

S rs12954795 107.89 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0001478 1.36 rs12954795 107.89 logistic Ml vs no Ml (at entry) 18 0.0003298 1.37 rs12954795 107.89 logistic Ml vs no Ml (follow-up) 18 0.0004025 1.36 rs12965571 41.69 logistic AGE:SEX Ml vs control (follow-up) 18 0.0001076 1.47 rs12965571 41.69 logistic Ml vs control (follow-up) 18 0.0001823 1.47 rs12965580 95.84 logistic AGEiSEX Ml vs no Ml (at entry) 18 8.98E-05 1.44 rs12965580 95.84 logistic Ml vs no Ml (at entry) 18 9.04E-05 1.44 rs12965580 95.84 logistic AGE:SEX Ml vs no Ml (follow-up) 18 0.00013 1.43 rs12965580 95.84 logistic Ml vs no Ml (follow-up) 18 0.0001358 1.43 rs12965580 95.84 logistic AGE:SEX Ml vs control (at entry) 18 0.0001483 1.57 rs12965580 95.84 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0001599 1.44 rs12965580 95.84 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0002097 1.44 rs12965580 95.84 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.000222 1.43 rs12965580 95.84 logistic Ml vs control (at entry) 18 0.0002225 1.57 rs 12965580 95.84 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0002486 1.44 rs12965580 95.84 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 0.0002795 1.43 rs12965580 95.84 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 0.0002898 1.43 rs12965580 95.84 logistic AGE:SEX Ml vs control (follow-up) 18 0.0004429 1.60

rs12965580 95.84 logistic GE:AGE:CRCL:SEX IVII vs control (at entry) 18 0.0004466 1.57 rs12965580 95.84 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.000448 1.57 rs12987038 2.04 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 2 0.0001225 1.38 rs130250 31.07 logistic GE:AGE:SEX Ml vs control (follow-up) 22 0.0002953 0.70 rs130250 31.07 logistic GE:AGE:SEX Ml vs control (at entry) 22 0.0003911 0.73 rs13039735 38.70 logistic Ml vs no Ml (at entry) 20 7.70E-05 0.69 rs13039735 38.70 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 20 8.81 E-05 0.69 rs13039735 38.70 logistic GE:AGE:SEX Ml vs no Ml (at entry) 20 8.89E-05 0.69 rs13039735 38.70 logistic AGE:SEX Ml vs no Ml (at entry) 20 0.0001072 0.69 rs13039735 38.70 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 0.000233 0.69 rs13039735 38.70 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 20 0.000343 0.69 rs13070108 97.74 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0002584 0.69 rs13070108 97.74 logistic AGEiSEX Ml vs no Ml (follow-up) 3 0.0003209 0.70 rs13070108 97.74 logistic Ml vs no Ml (at entry) 3 0.0003324 0.69 rs13070108 97.74 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0003639 0.69 rs13070108 97.74 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0004165 0.69 rs13070108 97.74 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.000432 0.70

M rs13070108 97.74 logistic Ml vs no Ml (follow-up) 3 0.0004333 0.70 g rs130834 58.32 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 22 1.65E-05 2.16 rs130834 58.32 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 22 3.69E-05 2.16 rs130834 58.32 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 22 0.0001617 1.76 rs130834 58.32 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 22 0.0003046 1.76 rs13120271 60.12 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.000471 1.28 rs13127656 138.43 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0004625 0.73 rs13128284 124.20 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 6.85E-05 1.35 rs13128284 124.20 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 9.32E-05 1.34 rs13128284 124.20 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0001237 1.35 rs13128284 124.20 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0001595 1.34 rs13128284 124.20 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 4 0.0002707 1.40 rs13128284 124.20 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0002927 1.34 rs13128284 124.20 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0003216 1.35 rs13128284 124.20 logistic GE:AGE:SEX Ml vs control (at entry) 4 0.0003601 1.40 rs13138476 124.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0001657 1.32 rs13138476 124.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0002169 1.32 rs13138476 124.19 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0002888 1.32 rs13138476 124.19 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0003587 1.32

rs1316395 145.93 logistic Ml vs no Ml (at entry) 10 0.0001783 1.43 rs1316395 145.93 logistic GE:AGE:CRCLSEX Ml vs no Ml (at entry) 10 0.0001884 1.43 rs1316395 145.93 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0002282 1.43 rs1316395 145.93 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 0.0002467 1.43 rs1316395 145.93 logistic Ml vs no Ml (follow-up) 10 0.0002581 1.41 rs1316395 145.93 logistic AGE:SEX Ml vs no Ml (at entry) 10 0.0002953 1.43 rs1316395 145.93 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 0.0003221 1.41 rs1316395 145.93 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0003821 1.41 rs1316395 145.93 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.0004582 1.41 rs1316395 145.93 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0004722 1.41 rs1316801 54.34 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0001903 0.77 rs1316801 54.34 logistic Ml vs no Ml (follow-up) 8 0.0002425 0.77 rs1316801 54.34 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0003231 0.77 rs1316801 54.34 logistic AGE:SEX Ml vs control (at entry) 8 0.000347 0.74 rs1316801 54.34 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0003962 0.77 rs1316801 54.34 logistic AGE:SEX Ml vs no Ml (at entry) 8 0.0004368 0.78 rs13173656 165.73 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 2.50E-05 0.62 _w rs13173656 165.73 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 2.74E-05 0.58

£ rs13173656 165.73 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 2.83E-05 0.62 rs13173656 165.73 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 4.70E-05 0.62 rs13173656 165.73 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 5.17E-05 0.62 rs13173656 165.73 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 5.36E-05 0.62 rs13173656 165.73 logistic GE:AGE:SEX Ml vs control (at entry) 5 5.95E-05 0.58 rs13173656 165.73 logistic AGE:SEX Ml vs no Ml (follow-up) 5 7.45E-05 0.62 rs13173656 165.73 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 8.53E-05 0.62 rs13173656 165.73 logistic Ml vs no Ml (follow-up) 5 0.0001025 0.62 rs13173656 165.73 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0001049 0.62 rs13173656 165.73 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 5 0.0001056 0.59 rs13173656 165.73 logistic AGE:SEX Ml vs no Ml (at entry) 5 0.0001283 0.62 rs13173656 165.73 logistic GE:AGE:SEX Ml vs control (follow-up) 5 0.0001643 0.59 rs13173656 165.73 logistic Ml vs no Ml (at entry) 5 0.0001643 0.62 rs13173656 165.73 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0001778 0.62 rs13173656 165.73 logistic Ml vs control (at entry) 5 0.0002135 0.58 rs13173656 165.73 logistic AGE:SEX Ml vs control (at entry) 5 0.0002885 0.58 rs13185405 179.62 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 5 1.01 E-05 0.71 rs13185405 179.62 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 3.34E-05 0.71

rsi 3185405 179.62 logistic AGE:SEX Ml vs control (at entry) 5 0.0002314 0.71 rs13185405 179.62 logistic Ml vs control (at entry) 5 0.0003704 0.71 rs13185405 179.62 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 5 0.0004175 0.71 rs1319458 156.28 logistic AGE:SEX Ml vs control (follow-up) 8 0.000246 1.43 rs1319458 156.28 logistic Ml vs control (follow-up) 8 0.0003395 1.43 rs1319458 156.28 logistic AGE:SEX Ml vs control (at entry) 8 0.0004377 1.37 rs1319458 156.28 logistic Ml vs control (at entry) 8 0.0004964 1.37 rs1320865 130.51 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0002631 1.43 rs1320865 130.51 logistic GE:AGE:SEX Ml vs control (at entry) 2 0.0004605 1.43 rs13234372 121.38 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.0003004 1.30 rs13234372 121.38 logistic AGE:SEX Ml vs no Ml (follow-up) 7 0.0003097 1.30 rs13234372 121.38 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 0.0003959 1.30 rs13234372 121.38 logistic Ml vs no Ml (follow-up) 7 0.0004174 1.30 rs13234372 121.38 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 0.0004945 1.30 rs1324465 59.11 logistic Ml vs no Ml (at entry) 9 0.0002339 1.29 rs1324465 59.11 logistic AGE:SEX Ml vs no Ml (at entry) 9 0.000293 1.29 rs13250299 164.17 logistic AGE:SEX Ml vs control (at entry) 8 0.0003134 0.73 rs13250299 164.17 logistic Ml vs control (at entry) 8 0.0004992 0.73

K) κ> rs1325267 99.33 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0002641 0.66 rs1325267 99.33 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0002802 0.66 rs1325267 99.33 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 0.0004181 0.64 rs1325267 99.33 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.000482 0.64 rs13259448 6.07 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 7.96E-05 0.78 rs13259448 6.07 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0003102 0.79 rs13263794 66.42 logistic Ml vs control (at entry) 8 0.000466 0.59 rs13266699 14.53 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0003408 1.30 rs13267118 6.08 logistic AGE:SEX Ml vs control (follow-up) 8 0.0002342 0.69 rs13267118 6.08 logistic AGE:SEX Ml vs control (at entry) 8 0.0003531 0.72 rs13273013 101.80 logistic AGE:SEX Ml vs control (at entry) 8 4.02E-05 1.42 rs13273013 101.80 logistic Ml vs control (at entry) 8 4.97E-05 1.42 rs13276054 46.70 logistic AGE:SEX Ml vs control (follow-up) 8 0.0003426 0.70 rs1328907 25.84 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 9 0.0003961 1.47 rs1328907 25.84 logistic GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0004837 1.47 rs13316352 172.25 logistic Ml vs control (at entry) 3 5.03E-06 1.60 rs13316352 172.25 logistic AGE:SEX Ml vs control (at entry) 3 6.69E-06 1.60 rs13316352 172.25 logistic Ml vs control (follow-up) 3 3.59E-05 1.61

rs13316352 172.25 logistic AGE:SEX WII vs control (follow-up) 3 5.29E-05 1.61 rs13316352 172.25 logistic GE:AGE:SEX Ml vs control (at entry) 3 5.62E-05 1.60 rs13316352 172.25 logistic AGE:SEX Ml vs no Ml (at entry) 3 8.10E-05 1.36 rs13316352 172.25 logistic Ml vs no Ml (at entry) 3 8.51 E-05 1.36 rs13316352 172.25 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 3 9.52E-05 1.60 rs13316352 172.25 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.000126 1.36 rs13316352 172.25 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.000148 1.36 rs13316352 172.25 logistic AGE:SEX Ml vs no Ml (follow-up) 3 0.0002001 1.34 rs13316352 172.25 logistic Ml vs no Ml (follow-up) 3 0.0002124 1.34 rs13316352 172.25 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 0.000294 1.34 rs13316352 172.25 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0003401 1.34 rs13316352 172.25 logistic GE:AGE:SEX Ml vs control (follow-up) 3 0.0003791 1.61 rs13326400 64.17 logistic Ml vs control (at entry) 3 0.0004019 0.44 rs1333996 26.34 logistic Ml vs control (follow-up) 9 5.25E-05 1.52 rs1333996 26.34 logistic AGE:SEX Ml vs control (follow-up) 9 0.0001335 1.52 rs1333996 26.34 logistic Ml vs control (at entry) 9 0.0001606 1.42 rs1333996 26.34 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0001982 1.52 rs1333996 26.34 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 0.0003037 1.52

K) rs1333996 26.34 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 9 0.0003361 1.52 rs1333996 26.34 logistic AGE:SEX Ml vs control (at entry) 9 0.0003498 1.42 rs13353636 16.63 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 4 4.48E-05 0.62 rs13353636 16.63 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 4 0.0001349 0.62 rs13353636 16.63 logistic Ml vs control (at entry) 4 0.0001369 0.62 rs13353636 16.63 logistic GE:AGE:SEX Ml vs control (at entry) 4 0.0001602 0.62 rs13353636 16.63 logistic AGE:SEX Ml vs control (at entry) 4 0.0001651 0.62 rs13353636 16.63 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.00045 0.66 rs1335655 17.96 logistic AGE:SEX Ml vs control (at entry) 13 0.0001814 0.73 rs1335655 17.96 logistic Ml vs control (at entry) 13 0.0002912 0.73 rs1337966 26.41 logistic Ml vs no Ml (at entry) 13 1.58E-05 0.50 rs1337966 26.41 logistic AGE:SEX Ml vs no Ml (at entry) 13 2.70E-05 0.50 rs1337966 26.41 logistic GE:AGE:SEX Ml vs no Ml (at entry) 13 2.86E-05 0.50 rs1337966 26.41 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 13 3.45E-05 0.50 rs 1337966 26.41 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 13 6.00E-05 0.50 rs1337966 26.41 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 0.0001127 0.50 rs1337966 26.41 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 13 0.000246 0.54 rs1337966 26.41 logistic GE:AGE:SEX Ml vs control (at entry) 13 0.0003504 0.54

rs1338195 99.28 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0001466 0.73 rs1338195 99.28 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0001576 0.73 rs1338195 99.28 logistic AGE:SEX Ml vs control (at entry) 1 0.0003021 0.73 rs1338195 99.28 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.0003078 0.73 rs13382085 97.34 logistic Ml vs no Ml (at entry) 19 9.96E-06 0.36 rs13382085 97.34 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 19 1.22E-05 0.36 rs13382085 97.34 logistic GE:AGE:SEX Ml vs no Ml (at entry) 19 1.22E-05 0.36 rs13382085 97.34 logistic AGEiSEX Ml vs no Ml (at entry) 19 1.85E-05 0.36 rs13382085 97.34 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 19 2.70E-05 0.36 rs13382085 97.34 logistic Ml vs control (at entry) 19 2.97E-05 0.33 rs13382085 97.34 logistic AGE:SEX Ml vs control (at entry) 19 4.21 E-05 0.33 rs13382085 97.34 logistic Ml vs no Ml (follow-up) 19 5.33E-05 0.42 rs13382085 97.34 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 19 7.64E-05 0.42 rs13382085 97.34 logistic GE:AGE:SEX Ml vs control (at entry) 19 8.16E-05 0.33 rs13382085 97.34 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 19 8.60E-05 0.42 rs13382085 97.34 logistic AGE:SEX Ml vs no Ml (follow-up) 19 0.0001068 0.42 rs13382085 97.34 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 19 0.0001616 0.42 κ> rs13382085 97.34 logistic Ml vs control (follow-up) 19 0.0001729 0.37

£ rs13382085 97.34 logistic AGEiSEX Ml vs control (follow-up) 19 0.0002131 0.37 rs13382085 97.34 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 19 0.0002375 0.33 rs13382085 97.34 logistic GE:AGE:SEX Ml vs control (follow-up) 19 0.0002883 0.37 rs13382085 97.34 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 19 0.0003611 0.36 rs13406490 19.56 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 7.90E-05 1.35 rs13423425 115.60 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0001552 1.38 rs1351719 59.52 logistic AGEiSEX Ml vs control (follow-up) 5 0.000395 0.69 rs135439 48.93 logistic HBPIGEIAGEISEX Ml vs control (at entry) 22 5.86E-05 1.40 rs135439 48.93 logistic HBPIGEIAGEISEX Ml vs control (follow-up) 22 0.0003898 1.35 rs1357814 96.04 logistic HBPIGEIAGEISEX Ml vs control (at entry) 7 6.77E-05 0.81 rs136002 52.89 logistic GEiAGEiCRCLiSEX Ml vs no Ml (follow-up) 22 0.0001272 0.75 rs136002 52.89 logistic GEiAGEiACRiSEX Ml vs no Ml (follow-up) 22 0.0002349 0.75 rs136002 52.89 logistic GEIAGEICRCLISEX Ml vs no Ml (at entry) 22 0.0002653 0.76 rs136002 52.89 logistic GEIAGEISEX Ml vs no Ml (follow-up) 22 0.0003014 0.75 rs136026 52.93 logistic GEIAGEICRCLISEX Ml vs no Ml (at entry) 22 0.000315 0.77 rs136026 52.93 logistic GEIAGEICRCLISEX Ml vs no Ml (follow-up) 22 0.0004508 0.78 rs1360411 32.66 logistic AGEISEX Ml vs control (follow-up) 9 6.70E-05 1.47 rs1360411 32.66 logistic Ml vs control (follow-up) 9 8.32E-05 1.47

rs1360422 126.45 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0001013 1.34 rs1360422 126.45 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0002493 1.34 rs1360422 126.45 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 0.0003233 1.34 rs1360422 126.45 logistic GE:AGE:SEX Ml vs control (at entry) 10 0.0004178 1.41 rs1360422 126.45 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 0.0004411 1.41 rs1362936 53.21 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 17 0.0004956 1.25 rs1366460 39.64 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0002011 0.80 rs1366460 39.64 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.0004055 0.80 rs1366460 39.64 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0004795 0.80 rs1376985 93.55 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 0.000423 0.79 rs1379666 88.63 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 6 0.0004801 1.42 rs1384300 111.43 logistic AGE:SEX Ml vs control (at entry) 3 0.0004775 1.74 rs1385662 116.87 logistic AGEiSEX Ml vs no Ml (follow-up) 4 0.0004484 1.33 rs1385662 116.87 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0004875 1.33 rs1389798 93.69 logistic AGE:SEX Ml vs control (at entry) 12 0.0001118 0.70 rs1389798 93.69 logistic Ml vs control (at entry) 12 0.0001239 0.70 rs1389798 93.69 logistic Ml vs control (follow-up) 12 0.0003137 0.69 rs1389798 93.69 logistic AGE:SEX Ml vs control (follow-up) 12 0.0003586 0.69

K) rs1392326 176.89 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 7.13E-05 1.38 rs1396512 63.61 logistic Ml vs control (follow-up) 14 8.01 E-05 1.72 rs1396512 63.61 logistic AGEiSEX Ml vs control (follow-up) 14 0.0001379 1.72 rs1396512 63.61 logistic Ml vs control (at entry) 14 0.0002257 1.56 rs1396512 63.61 logistic AGEiSEX Ml vs control (at entry) 14 0.0003024 1.56 rs1396512 63.61 logistic GEIAGEISEX Ml vs control (follow-up) 14 0.0003715 1.72 rs1397706 163.66 logistic Ml vs control (follow-up) 2 0.0004243 2.07 rs1398899 63.51 logistic GEIAGEISEX Ml vs control (at entry) 18 0.000313 1.42 rs1398899 63.51 logistic AGEISEX Ml vs control (at entry) 18 0.0004334 1.42 rs1401209 116.28 logistic GEiAGEiCRCLiSEX Ml vs no Ml (at entry) 2 0.0003653 1.36 rs1404868 93.65 logistic AGEiSEX Ml vs control (at entry) 12 0.0001382 0.70 rs1404868 93.65 logistic Ml vs control (at entry) 12 0.0001467 0.70 rs1404868 93.65 logistic Ml vs control (follow-up) 12 0.0003128 0.69 rs1404868 93.65 logistic AGEiSEX Ml vs control (follow-up) 12 0.000359 0.69 rs1405377 79.50 logistic HBPIGEIAGEISEX Ml vs control (follow-up) 4 0.0002615 1.32 rs1413896 48.10 logistic GEiAGEiACRiSEX Ml vs control (follow-up) 6 0.0001593 1.62 rs1413896 48.10 logistic Ml vs control (follow-up) 6 0.0002242 1.62 rs1413896 48.10 logistic AGEiSEX Ml vs control (follow-up) 6 0.0003425 1.62

rs1413896 48.10 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.0003656 1.52 rs1413896 48.10 logistic WII vs control (at entry) 6 0.0004388 1.52 rs1413896 48.10 logistic GE:AGE:SEX Ml vs control (follow-up) 6 0.0004587 1.62 rs1413896 48.10 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 6 0.0004664 1.62 rs1428658 39.66 logistic GE:AGE:CRCLSEX Ml vs no Ml (follow-up) 5 0.0001339 0.79 rs1428658 39.66 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.0002387 0.79 rs1428658 39.66 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.000281 0.79 rs1428658 39.66 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.0004217 0.79 rs1446074 123.53 logistic AGE:SEX Ml vs no Ml (follow-up) . 5 0.0002513 0.78 rs1446074 123.53 logistic Ml vs no Ml (follow-up) 5 0.0003756 0.78 rs1453012 122.50 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.0004531 1.27 rs1453012 122.50 logistic Ml vs no Ml (follow-up) 5 0.0004803 1.27 rs1453688 130.56 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 7.26E-06 0.19 rs1453688 130.56 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 8.40E-06 0.19 rs1453688 130.56 logistic Ml vs no Ml (at entry) 2 8.47E-06 0.19 rs1453688 130.56 logistic GE:AGE:CRCLSEX Ml vs no Ml (at entry) 2 9.08E-06 0.19 rs1453688 130.56 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 1.67E-05 0.19 rs1453688 130.56 logistic AGEiSEX Ml vs no Ml (at entry)

K) 2 1.71E-05 0.19 rs1453688 130.56 logistic GE:AGE:SEX Ml vs control (at entry) 2 5.64E-05 0.21 rs1453688 130.56 logistic Ml vs no Ml (follow-up) 2 8.12E-05 0.30 rs1453688 130.56 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 8.49E-05 0.21 rs1453688 130.56 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 8.82E-05 0.30 rs1453688 130.56 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 0.000114 0.30 rs1453688 130.56 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0001149 0.30 rs1453688 130.56 logistic Ml vs control (at entry) 2 0.000184 0.21 rs1453688 130.56 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0001991 0.30 rs1453688 130.56 logistic AGE:SEX Ml vs control (at entry) 2 0.0002024 0.21 rs1453688 130.56 logistic GE:AGE:SEX Ml vs control (follow-up) 2 0.0003444 0.31 rs1453688 130.56 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0003662 0.30 rs1453688 130.56 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0004634 0.21 rs1454285 6.09 logistic AGE:SEX Ml vs control (follow-up) 8 0.0003479 0.70 rs1454285 6.09 logistic AGEiSEX Ml vs control (at entry) 8 0.0004378 0.72 rs1454285 6.09 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0004522 0.78 rs1456994 120.29 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 14 1.02E-05 0.17 rs1456994 120.29 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 14 1.09E-05 0.17 rs1456994 120.29 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 14 1.17E-05 0.17

rs1456994 120.29 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 14 1.47E-05 0.15 rs1456994 120.29 logistic Ml vs no Ml (follow-up) 14 1.50E-05 0.17 rs1456994 120.29 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 14 1.53E-05 0.15 rs1456994 120.29 logistic GE:AGE:SEX Ml vs no Ml (at entry) 14 1.61E-05 0.15 rs1456994 120.29 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 14 2.35E-05 0.17 rs1456994 120.29 logistic Ml vs no Ml (at entry) 14 2.40E-05 0.15 rs1456994 120.29 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 14 2.97E-05 0.15 rs1456994 120.29 logistic AGE:SEX Ml vs no Ml (follow-up) 14 3.21 E-05 0.17 rs1456994 120.29 logistic AGE:SEX Ml vs no Ml (at entry) 14 4.29E-05 0.15 rs1456994 120.29 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 14 0.0003235 0.20 rs1456994 120.29 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 14 0.0003813 0.20 rs1456994 120.29 logistic GE:AGE:SEX Ml vs control (follow-up) 14 0.0004464 0.20 rs1460607 59.78 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0001655 0.59 rs1460607 59.78 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.000195 0.59 rs1460607 59.78 logistic Ml vs no Ml (at entry) 4 0.0002123 0.59 rs1460607 59.78 logistic AGE:SEX Ml vs no Ml (at entry) 4 0.0002588 0.59 rs1460607 59.78 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0003941 0.59 rs1466462 66.09 logistic AGE:SEX Ml vs control (follow-up) 11

K) 5.85E-05 1.43 rs1466462 66.09 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0001581 1.29 rs1466462 66.09 logistic Ml vs control (follow-up) 11 0.0001818 1.43 rs1466462 66.09 logistic AGE:SEX Ml vs control (at entry) 11 0.0002556 1.35 rs1466462 66.09 logistic Ml vs no Ml (at entry) 11 0.0003167 1.29 rs1466462 66.09 logistic Ml vs control (at entry) 11 0.0004861 1.35 rs1481384 161.33 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 2 0.0002236 0.84 rs1484255 43.07 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 4 0.0001142 1.58 rs1484255 43.07 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 4 0.0001908 1.47 rs1484992 92.55 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.000353 0.70 rs1487025 97.87 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0001077 0.52 rs1487025 97.87 logistic Ml vs no Ml (at entry) 2 0.0001215 0.52 rs1487025 97.87 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0001903 0.52 rs1487025 97.87 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0002288 0.52 rs1487025 97.87 logistic Ml vs no Ml (follow-up) 2 0.0003765 0.56 rs1487025 97.87 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0003898 0.56 rs1487025 97.87 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 0.0004125 0.52 rs1487025 97.87 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0004358 0.52 rs1487802 187.94 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 5 0.0004071 0.84

rs1500292 79.55 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 16 0.0002504 0.82 rs150073 27.14 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 16 0.0003702 1.51 rs1507214 93.71 logistic Ml vs control (at entry) 12 0.0002327 0.70 rs1507214 93.71 logistic AGE:SEX Ml vs control (at entry) 12 0.0002382 0.70 rs1507214 93.71 logistic Ml vs control (follow-up) 12 0.0003432 0.69 rs1507214 93.71 logistic AGE:SEX Ml vs control (follow-up) 12 0.0004349 0.69 rs1507216 93.70 logistic AGE:SEX Ml vs control (at entry) 12 0.0001537 0.70 rs1507216 93.70 logistic Ml vs control (at entry) 12 0.0001748 0.70 rs1507216 93.70 logistic Ml vs control (follow-up) 12 0.0003163 0.69 rs1507216 93.70 logistic AGE:SEX Ml vs control (follow-up) 12 0.0003357 0.69 rs1511098 124.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0002506 1.44 rs1511098 124.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0003819 1.42 rs1511098 124.19 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0004249 1.44 rs1513679 63.53 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0001826 1.42 rs1513679 63.53 logistic AGE:SEX Ml vs control (at entry) 18 0.0002542 1.42 rs1513679 63.53 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0003072 1.42 rs1513679 63.53 logistic Ml vs control (at entry) 18 0.0003385 1.42 rs1513681 63.54 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0001517 1.42

K)

OO rs1513681 63.54 logistic AGE:SEX Ml vs control (at entry) 18 0.000209 1.42 rs1513681 63.54 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0002718 1.42 rs1513681 63.54 logistic Ml vs control (at entry) 18 0.0002854 1.42 rs1514417 17.87 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 21 0.0001122 1.44 rs1514417 17.87 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 21 0.0003117 1.45 rs1515633 116.91 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.0004806 1.41 rs1518909 80.38 logistic AGEiSEX Ml vs control (follow-up) 6 0.0002628 0.70 rs1518909 80.38 logistic Ml vs control (follow-up) 6 0.0003814 0.70 rs1520472 187.70 logistic Ml vs no Ml (at entry) 2 7.02E-06 0.36 rs1520472 187.70 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 7.58E-06 0.36 rs1520472 187.70 logistic AGE:SEX Ml vs no Ml (at entry) 2 1.19E-05 0.36 rs 1520472 187.70 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 1.20E-05 0.36 rs 1520472 187.70 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 1.79E-05 0.36 rs1520472 187.70 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 2.33E-05 0.36 rs1520472 187.70 logistic Ml vs no Ml (follow-up) 2 3.07E-05 0.41 rs1520472 187.70 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 3.68E-05 0.41 rs1520472 187.70 logistic GE:AGE:SEX Ml vs control (at entry) 2 5.61 E-05 0.36 rs1520472 187.70 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 5.72E-05 0.41

rs1520472 187.70 logistic AGEiSEX Ml vs no Ml (follow-up) 2 5.83E-05 0.41 rs 1520472 187.70 logistic AGE:SEX Ml vs control (at entry) 2 7.68E-05 0.36 rs1520472 187.70 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 7.79E-05 0.36 rs1520472 187.70 logistic Ml vs control (at entry) 2 8.06E-05 0.36 rs1520472 187.70 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 9.40E-05 0.41 rs1520472 187.70 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0001443 0.41 rs1520472 187.70 logistic GE:AGE:SEX Ml vs control (follow-up) 2 0.0004108 0.42 rs1522469 21.88 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 7.87E-05 1.45 rs1522469 21.88 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0001538 1.50 rs1522469 21.88 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0003234 1.46 rs1523890 4.82 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 3 0.000157 1.38 rs 1523890 4.82 logistic GE:AGE:SEX Ml vs control (follow-up) 3 0.0003152 1.38 rs1523890 4.82 logistic AGE:SEX Ml vs control (follow-up) 3 0.0004051 1.38 rs1524181 106.82 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 3.83E-05 1.27 rs1524181 106.82 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 0.0001084 1.36 rs1524181 106.82 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 0.0001143 1.27 rs1524181 106.82 logistic AGE:SEX Ml vs no Ml (follow-up) 1 0.0004618 1.27 rs1524181 106.82 logistic Ml vs no Ml (follow-up) 1 0.0004721 1.27

K) rs152454 43.62 logistic Ml vs no Ml (at entry) 16 0.0003449 1.40 rs152454 43.62 logistic Ml vs no Ml (follow-up) 16 0.0004106 1.39 rs152454 43.62 logistic AGE:SEX Ml vs no Ml (at entry) 16 0.0004681 1.40 rs1528490 81.56 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 17 0.0003365 1.28 rs1532885 127.30 logistic Ml vs no Ml (at entry) 4 0.0001567 0.44 rs1532885 127.30 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0001793 0.44 rs1532885 127.30 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0001918 0.44 rs1532885 127.30 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0002999 0.44 rs1532885 127.30 logistic AGE:SEX Ml vs no Ml (at entry) 4 0.0003194 0.44 rs1532885 127.30 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0004085 0.44 rs1536792 25.83 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 9 0.0001624 1.51 rs1536792 25.83 logistic GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0002266 1.51 rs1540369 201.17 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 2 0.0004401 1.15 rs1540899 124.57 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 9.34E-05 0.72 rs1540899 124.57 logistic GE:AGE:SEX Ml vs control (at entry) 8 9.58E-05 0.72 rs1540899 124.57 logistic AGE:SEX Ml vs control (at entry) 8 0.0001465 0.72 rs1540899 124.57 logistic Ml vs control (at entry) 8 0.0001922 0.72 rs1541749 8.50 logistic AGE:SEX Ml vs control (at entry) 8 0.0004535 0.70

rs1542744 125.72 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.000157 0.66 rs1550243 141.54 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0001191 0.79 rs 1550243 141.54 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0002423 0.79 rs1550243 141.54 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0003433 0.79 rs1550243 141.54 logistic Ml vs no Ml (at entry) 2 0.0003811 0.79 rs1550250 19.48 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0002926 1.28 rs1558531 17.04 logistic AGE:SEX Ml vs control (follow-up) 12 1.53E-05 0.40 rs1558531 17.04 logistic GE:AGE:SEX Ml vs control (follow-up) 12 2.60E-05 0.40 rs1558531 17.04 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 3.09E-05 0.40 rs1558531 17.04 logistic Ml vs control (follow-up) 12 4.01 E-05 0.40 rs1558531 17.04 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 6.46E-05 0.40 rs1558531 17.04 logistic AGE:SEX Ml vs control (at entry) 12 0.0001068 0.45 rs1558531 17.04 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.0001239 0.45 rs1558531 17.04 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0001672 0.45 rs1558531 17.04 logistic Ml vs control (at entry) 12 0.000235 0.45 rs1558532 17.04 logistic AGEiSEX Ml vs control (follow-up) 12 1.98E-05 0.42 rs1558532 17.04 logistic GE:AGE:SEX Ml vs control (follow-up) 12 3.38E-05 0.42 rs1558532 17.04 logistic GE:AGE:CRCLSEX Ml vs control (follow-up) 12 3.98E-05 0.42

O rs1558532 17.04 logistic Ml vs control (follow-up) 12 4.89E-05 0.42 rs1558532 17.04 logistic AGEiSEX Ml vs control (at entry) 12 0.0001404 0.47 rs1558532 17.04 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0001511 0.42 rs1558532 17.04 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.0001767 0.47 rs1558532 17.04 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0002255 0.47 rs1558532 17.04 logistic Ml vs control (at entry) 12 0.0002996 0.47 rs1558533 17.04 logistic AGE:SEX Ml vs control (follow-up) 12 1.72E-05 0.42 rs1558533 17.04 logistic GE:AGE:SEX Ml vs control (follow-up) 12 3.04E-05 0.42 rs1558533 17.04 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 3.56E-05 0.42 rs1558533 17.04 logistic Ml vs control (follow-up) 12 4.31 E-05 0.42 rs1558533 17.04 logistic AGEiSEX Ml vs control (at entry) 12 0.0001227 0.47 rs1558533 17.04 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0001426 0.42 rs1558533 17.04 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.0001591 0.47 rs1558533 17.04 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0002016 0.47 rs1558533 17.04 logistic Ml vs control (at entry) 12 0.000265 0.47 rs1559145 159.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0003488 1.29 rs1560346 64.45 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0004767 1.24 rs1560718 48.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 19 0.0004614 1.22

rs1564860 125.77 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.0004236 0.73 rs1568272 47.63 logistic AGE:SEX Ml vs no Ml (follow-up) 11 0.0002997 0.78 rs1568272 47.63 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0003704 0.77 rs1568272 47.63 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0004092 0.78 rs156851 35.77 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.000414 0.59 rs1576939 16.51 logistic AGE:SEX Ml vs control (follow-up) 9 0.0004756 0.73 rs1595764 187.92 logistic AGE:SEX Ml vs control (follow-up) 2 0.0001015 0.29 rs1595764 187.92 logistic Ml vs control (follow-up) 2 0.0001154 0.29 rs1601435 28.59 logistic GE:AGE:SEX Ml vs control (follow-up) 8 0.0002274 1.99 rs1601435 28.59 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 8 0.0003685 1.99 rs1603614 60.12 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0003359 0.76 rs1603614 60.12 logistic GE:AGE:SEX Ml vs control (follow-up) 4 0.0004212 0.76 rs1603614 60.12 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 4 0.0004807 0.76 rs1604587 112.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0001393 0.74 rs1604587 112.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0003513 0.75 rs1604587 112.06 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0003792 0.74 rs1604587 112.06 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0003838 0.74

^ rs1604587 112.06 logistic Ml vs no Ml (follow-up) 4 0.0004054 0.74

£ rs1610 43.61 logistic Ml vs no Ml (at entry) 16 0.0003571 1.40 rs1610 43.61 logistic Ml vs no Ml (follow-up) 16 0.0004133 1.39 rs1610 43.61 logistic AGE:SEX Ml vs no Ml (at entry) 16 0.0004854 1.40 rs1614316 120.08 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0001879 0.79 rs1618798 70.24 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 9.06E-06 1.50 rs1618798 70.24 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 1 0.0001122 1.52 rs1618798 70.24 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 0.0001845 1.50 rs1618798 70.24 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 0.0004112 1.52 rs1630807 74.23 logistic AGE:SEX Ml vs no Ml (at entry) 13 0.0003726 0.77 rs1630807 74.23 logistic Ml vs no Ml (at entry) 13 0.0004207 0.77 rs1645410 98.00 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.000377 0.74 rs1645410 98.00 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.000441 0.74 rs166412 119.02 logistic GE:AGE:SEX Ml vs control (at entry) 1 5.52E-05 0.62 rs166412 119.02 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.000118 0.62 rs166412 119.02 logistic Ml vs control (at entry) 1 0.000123 0.62 rs166412 119.02 logistic AGE:SEX Ml vs control (at entry) 1 0.0001549 0.62 rs166412 119.02 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.0002562 0.64 rs166412 119.02 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 0.0004756 0.64

rs1673518 85.86 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0002838 1.31 rs1673518 85.86 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 0.0002873 1.34 rs1674241 66.36 logistic Ml vs control (at entry) 8 0.0004112 0.58 rs16822521 170.16 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0004623 0.56 rs16825798 186.76 logistic GE:AGE:SEX Ml vs control (at entry) 3 0.0003538 0.54 rs1682586 92.53 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.0004076 0.71 rs1682604 92.54 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.000353 0.70 rs16838929 8.84 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 4.82E-05 3.01 rs16838943 8.85 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 5.77E-05 3.00 rs16849108 80.68 logistic Ml vs control (at entry) 4 0.0003006 0.62 rs16849108 80.68 logistic AGEiSEX Ml vs control (at entry) 4 0.0003761 0.62 rs16849387 215.10 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.0002072 0.68 rs16849387 215.10 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 0.0002117 0.68 rs16849387 215.10 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 0.0003647 0.68 rs16849387 215.10 logistic AGE:SEX Ml vs control (follow-up) 1 0.0003678 0.68 rs16849387 215.10 logistic Ml vs control (follow-up) 1 0.0004145 0.68 rs16849387 215.10 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0004579 0.71 rs16849387 215.10 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0004615 0.71

K) rs16854019 178.94 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 3 9.01 E-05 1.51 rs16854019 178.94 logistic Ml vs control (follow-up) 3 0.0002292 1.51 rs16854019 178.94 logistic GE:AGE:SEX Ml vs control (follow-up) 3 0.0002608 1.51 rs16854019 178.94 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 3 0.0002885 1.39 rs16854019 178.94 logistic AGE:SEX Ml vs control (follow-up) 3 0.0002933 1.51 rs16855116 171.76 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.00046 0.73 rs16855116 171.76 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0004694 0.73 rs16862598 178.36 logistic AGE:SEX Ml vs control (at entry) 2 0.0004765 0.69 rs16865535 182.78 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0002133 1.59 rs16871059 127.53 logistic AGE:SEX Ml vs control (at entry) 7 0.0004563 1.68 rs16880395 43.28 logistic AGE:SEX Ml vs control (follow-up) 4 0.000366 0.72 rs16882335 150.05 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 0.0004908 1.62 rs16889490 64.47 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0002799 1.29 rs168965 74.18 logistic Ml vs control (at entry) 14 9.92E-06 1.65 rs168965 74.18 logistic AGE:SEX Ml vs control (at entry) 14 2.08E-05 1.65 rs168965 74.18 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 14 5.21 E-05 1.65 rs168965 74.18 logistic GE:AGE:SEX Ml vs control (at entry) 14 5.92E-05 1.65 rs168965 74.18 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 14 0.0002178 1.65

rs168965 74.18 logistic Ml vs no Ml (follow-up) 14 0.0002744 1.35 rs168965 74.18 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 14 0.0003759 1.35 rs168965 74.18 logistic Ml vs control (follow-up) 14 0.0003781 1.54 rs168965 74.18 logistic AGE:SEX Ml vs no Ml (follow-up) 14 0.0004378 1.35 rs16905587 94.49 logistic Ml vs control (at entry) 8 0.0001752 0.49 rs16905587 94.49 logistic Ml vs no Ml (at entry) 8 0.0002745 0.55 rs16905587 94.49 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 0.0002892 0.49 rs16905587 94.49 logistic AGE:SEX Ml vs control (at entry) 8 0.0002924 0.49 rs16905587 94.49 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 0.0003015 0.55 rs16905587 94.49 logistic Ml vs control (follow-up) 8 0.0003117 0.50 rs16905587 94.49 logistic GE:AGE:SEX Ml vs control (at entry) 8 0.0004151 0.49 rs16906665 94.58 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0004607 1.81 rs16910679 48.16 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0001122 1.24 rs16910679 48.16 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.00028 1.22 rs16915836 104.80 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0004022 0.65 rs16915836 104.80 logistic Ml vs no Ml (at entry) 8 0.0004189 0.65 rs16921797 1.53 logistic Ml vs no Ml (follow-up) 9 0.0001617 0.69 rs16921797 1.53 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 9 0.0001691 0.69 rs16921797 1.53 logistic AGE:SEX Ml vs no Ml (follow-up) 9 0.0002327 0.69 rs16921797 1.53 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0002601 0.69 rs16921797 1.53 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0004128 0.69 rs16930564 122.77 logistic Ml vs no Ml (at entry) 9 0.0001728 0.52 rs16930564 122.77 logistic GE:AGE:SEX Ml vs no M I ^' (at entry) 9 0.0002046 0.52 rs16930564 122.77 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 9 0.000255 0.52 rs16930564 122.77 logistic AGE:SEX Ml vs no Ml (at entry) 9 0.0002748 0.52 rs16930564 122.77 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 9 0.0004248 0.52 rs16930564 122.77 logistic GE:AGE:SEX Ml vs control (at entry) 9 0.0004769 0.51 rs16931436 27.18 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 9 0.0004025 0.79 rs16935391 72.45 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 0.0002214 1.43 rs16937197 64.01 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 0.0001766 0.61 rs16937197 64.01 logistic Ml vs control (at entry) 10 0.000222 0.61 rs16937197 64.01 logistic AGE:SEX Ml vs control (at entry) 10 0.0002504 0.61 rs16937197 64.01 logistic GE:AGE:SEX Ml vs control (at entry) 10 0.0003019 0.61

γS16937197 64.01 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 0.0003443 0.67 rs16937197 64.01 logistic Ml vs no Ml (follow-up) 10 0.0004504 0.67 rs16941191 125.62 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 16 0.0004516 0.61

rs16941250 125.66 logistic Ml vs control (follow-up) 16 0.0001414 0.45 rs16941250 125.66 logistic AGE:SEX Ml vs control (follow-up) 16 0.0003838 0.45 rs16943700 81.56 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 17 0.0003234 1.29 rs16948951 69.70 logistic Ml vs no Ml (follow-up) 17 3.88E-05 0.71 rs16948951 69.70 logistic AGEiSEX Ml vs no Ml (follow-up) 17 5.05E-05 0.71 rs16948951 69.70 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 17 5.09E-05 0.71 rs16948951 69.70 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 17 0.0001972 0.71 rs16948951 69.70 logistic Ml vs no Ml (at entry) 17 0.0003084 0.73 rs 16948951 69.70 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 17 0.0003456 0.71 rs16948951 69.70 logistic AGE:SEX Ml vs no Ml (at entry) 17 0.0003794 0.73 rs16948951 69.70 logistic Ml vs control (follow-up) 17 0.0004241 0.68 rs16948981 69.72 logistic Ml vs no Ml (follow-up) 17 4.33E-05 0.71 rs16948981 69.72 logistic AGE:SEX Ml vs no Ml (follow-up) 17 5.86E-05 0.71 rs16948981 69.72 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 17 5.94E-05 0.71 rs16948981 69.72 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 17 0.000226 0.71 rs16948981 69.72 logistic Ml vs no Ml (at entry) 17 0.0003445 0.74 rs16948981 69.72 logistic Ml vs control (follow-up) 17 0.0003743 0.67 _w rs16948981 69.72 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 17 0.0003895 0.71

£ rs16948981 69.72 logistic AGE:SEX Ml vs no Ml (at entry) 17 0.000437 0.74 rs16949733 100.65 logistic Ml vs no Ml (follow-up) 16 6.65E-05 1.47 rs16949733 100.65 logistic Ml vs no Ml (at entry) 16 6.83E-05 1.47 rs16949733 100.65 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 16 8.11 E-05 1.47 rs16949733 100.65 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 16 8.15E-05 1.47 rs16949733 100.65 logistic AGE:SEX Ml vs no Ml (follow-up) 16 8.42E-05 1.47 rs16949733 100.65 logistic AGE:SEX Ml vs no Ml (at entry) 16 8.43E-05 1.47 rs16949733 100.65 logistic GE:AGE:SEX Ml vs no Ml (at entry) 16 9.02E-05 1.47 rs16949733 100.65 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 16 9.04E-05 1.47 rs16949733 100.65 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 16 9.97E-05 1.47 rs16949733 100.65 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 16 0.0001716 1.47 rs16949733 100.65 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 16 0.0004791 1.47 rs16949733 100.65 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 16 0.0004996 1.47 rs16954017 74.92 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 15 7.14E-05 1.34 rs1695624 11.43 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 2.46E-05 0.74 rs1695624 11.43 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0003908 0.74 rs16969797 55.88 logistic GE:AGE:SEX Ml vs no Ml (at entry) 17 0.0001952 0.31 rs16969797 55.88 logistic Ml vs no Ml (at entry) 17 0.0002015 0.31

rs16969797 55.88 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 17 0.0002265 0.31 rs16969797 55.88 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 17 0.0002468 0.31 rs16969797 55.88 logistic HBP:GE:AGE:SEX WII vs no Ml (at entry) 17 0.0002747 0.31 rs16969797 55.88 logistic AGE:SEX Ml vs no Ml (at entry) 17 0.0003958 0.31 rs16973718 45.41 logistic Ml vs no Ml (follow-up) 16 2.42E-06 0.27 rs16973718 45.41 logistic AGE:SEX Ml vs no Ml (follow-up) 16 6.03E-06 0.27 rs16973718 45.41 logistic Ml vs no Ml (at entry) 16 1.11 E-05 0.30 rs16973718 45.41 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 16 1.33E-05 0.27 rs16973718 45.41 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 16 1.50E-05 0.27 rs16973718 45.41 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 16 2.32E-05 0.27 rs16973718 45.41 logistic AGE:SEX Ml vs no Ml (at entry) 16 2.39E-05 0.30 rs16973718 45.41 logistic GE:AGE:SEX Ml vs no Ml (at entry) 16 5.50E-05 0.30 rs16973718 45.41 logistic GE:AGE:CRCLSEX Ml vs no Ml (at entry) 16 6.27E-05 0.30 rs16973718 45.41 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 16 8.99E-05 0.30 rs16973718 45.41 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 16 0.0001076 0.27 rs16973718 45.41 logistic Ml vs control (at entry) 16 0.0003332 0.34 rs16973718 45.41 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 16 0.0004376 0.30 rs16975959 104.11 logistic GE:AGE:SEX Ml vs no Ml (at entry) 15 3.35E-07 0.21 rs16975959 104.11 logistic Ml vs no Ml (at entry) 15 3.98E-07 0.21 rs16975959 104.11 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 15 5.64E-07 0.21 rs16975959 104.11 logistic AGE:SEX Ml vs no Ml (at entry) 15 6.26E-07 0.21 rs16975959 104.11 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 15 7.22E-07 0.21 rs16975959 104.11 logistic AGEiSEX Ml vs control (at entry) 15 1.91 E-06 0.21 rs16975959 104.11 logistic GE:AGE:SEX Ml vs control (at entry) 15 2.00E-06 0.21 rs16975959 104.11 logistic Ml vs control (at entry) 15 2.21 E-06 0.21 rs16975959 104.11 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 15 2.61 E-06 0.21 rs16975959 104.11 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 15 3.24E-06 0.21 rs16975959 104.11 logistic Ml vs no Ml (follow-up) 15 4.74E-06 0.30 rs16975959 104.11 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 15 4.94E-06 0.30 rs16975959 104.11 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 15 8.61 E-06 0.30 rs16975959 104.11 logistic AGE:SEX Ml vs no Ml (follow-up) 15 8.79E-06 0.30 rs16975959 104.11 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 15 1.29E-05 0.30 rs16975959 104.11 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 15 6.05E-05 0.30 rs16975959 104.11 logistic AGE:SEX Ml vs control (follow-up) 15 7.16E-05 0.31 rs16975959 104.11 logistic Ml vs control (follow-up) 15 8.44E-05 0.31 rs16975959 104.11 logistic GE:AGE:SEX Ml vs control (follow-up) 15 9.22E-05 0.31

rs16975959 104.11 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 15 0.0001536 0.21 rs16975959 104.11 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 15 0.0001547 0.31 rs16988107 54.19 logistic GE:AGE:SEX Ml vs control (at entry) 20 0.000485 0.65 rs16988954 55.56 logistic GE:AGE:SEX Ml vs no Ml (at entry) 20 0.0001806 0.44 rs16988954 55.56 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 20 0.000391 0.44 rs16988954 55.56 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 20 0.0004008 0.44 rs16988954 55.56 logistic GE:AGE:SEX Ml vs control (at entry) 20 0.0004037 0.44 rs16988954 55.56 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 0.0004252 0.44 rs 16994496 33.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 20 1.25E-05 0.47 rs16994496 33.75 logistic Ml vs no Ml (at entry) 20 2.06E-05 0.47 rs16994496 33.75 logistic GE:AGE:SEX Ml vs no Ml (at entry) 20 2.64E-05 0.47 rs16994496 33.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 20 3.57E-05 0.47 rs 16994496 33.75 logistic AGE:SEX Ml vs no Ml (at entry) 20 4.50E-05 0.47 rs16994496 33.75 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 7.95E-05 0.47 rs16994496 33.75 logistic Ml vs no Ml (follow-up) 20 0.000211 0.54 rs16994496 33.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 20 0.0002207 0.54 rs16994496 33.75 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 20 0.0003321 0.54 rs16994496 33.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 20 0.000432 0.54 rs17004748 54.62 logistic GE:AGE:SEX Ml vs no Ml (at entry) 21 4.56E-05 0.46 rs17004748 54.62 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 21 7.04E-05 0.46 rs17004748 54.62 logistic Ml vs no Ml (at entry) 21 8.90E-05 0.46 rs17004748 54.62 logistic AGE:SEX Ml vs no Ml (at entry) 21 0.0001067 0.46 rs17004748 54.62 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 21 0.0001452 0.46 rs17004748 54.62 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 21 0.0001764 0.46 rs17011383 93.10 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0003835 0.78 rs17021814 136.72 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 0.0003348 0.59 rs17021814 136.72 logistic Ml vs no Ml (at entry) 1 0.000352 0.59 rs17021814 136.72 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0004101 0.59 rs17021814 136.72 logistic AGEiSEX Ml vs no Ml (at entry) 1 0.0004664 0.59 rs17022224 59.24 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 1.48E-07 0.26 rs17022224 59.24 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 3.01 E-07 0.26 rs17022224 59.24 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 4.44E-07 0.30 rs17022224 59.24 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 6.14E-07 0.26 rs17022224 59.24 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 8.68E-07 0.26 rs17022224 59.24 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 8.97E-07 0.30 rs17022224 59.24 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 2.31 E-06 0.30

rs17022224 59.24 logistic GE:AGE:SEX Ml vs control (at entry) 2 2.72E-06 0.29 rs17022224 59.24 logistic Ml vs no Ml (at entry) 2 3.35E-06 0.26 rs17022224 59.24 logistic GE:AGE:SEX Ml vs control (follow-up) 2 3.39E-06 0.31 rs17022224 59.24 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 3.77E-06 0.30 rs17022224 59.24 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 2 5.18E-06 0.31 rs17022224 59.24 logistic Ml vs no Ml (follow-up) 2 5.66E-06 0.30 rs17022224 59.24 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 5.80E-06 0.29 rs17022224 59.24 logistic AGE:SEX Ml vs no Ml (at entry) 2 6.27E-06 0.26 rs17022224 59.24 logistic AGE:SEX Ml vs no Ml (follow-up) 2 1.21 E-05 0.30 rs17022224 59.24 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 2 6.40E-05 0.31 rs17022224 59.24 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0001329 0.29 rs17022224 59.24 logistic Ml vs control (at entry) 2 0.0001976 0.29 rs17022224 59.24 logistic Ml vs control (follow-up) 2 0.0002238 0.31 rs17022224 59.24 logistic AGE:SEX Ml vs control (at entry) 2 0.00032 0.29 rs17025374 113.04 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0001125 1.36 rs17025374 113.04 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0001501 1.35 rs17025374 113.04 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 0.0001905 1.36 rs17025374 113.04 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0001933 1.36 rs 17025374 113.04 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 0.0002102 1.35 rs17025374 113.04 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0002551 1.35 rs17025374 113.04 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0004576 1.36 rs17025378 113.04 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 8.25E-05 1.36 rs17025378 113.04 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0001168 1.35 rs17025378 113.04 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 0.0001462 1.36 rs17025378 113.04 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0001499 1.36 rs17025378 113.04 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 0.0001702 1.35 rs17025378 113.04 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0002089 1.35 rs17025378 113.04 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0004934 1.36 rs17027538 104.81 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 2.98E-05 0.38 rs17027538 104.81 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 4.32E-05 0.38 rs17027538 104.81 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 7.34E-05 0.38 rs17027538 104.81 logistic Ml vs no Ml (at entry) 4 8.13E-05 0.38 rs17027538 104.81 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0001053 0.38 rs17027538 104.81 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0001375 0.43 rs17027538 104.81 logistic AGE:SEX Ml vs no Ml (at entry) 4 0.0001455 0.38 rs17027538 104.81 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0001634 0.43

rs17027538 104.81 logistic Ml vs no Ml (follow-up) 4 0.0002453 0.43 rs17027538 104.81 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.000267 0.43 rs17027538 104.81 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0004931 0.43 rs17027580 58.29 logistic Ml vs no Ml (at entry) 3 0.0001031 1.39 rs17027580 58.29 logistic Ml vs no Ml (follow-up) 3 0.0001064 1.39 rs17027580 58.29 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0001592 1.39 rs17027580 58.29 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0001745 1.39 rs17027580 58.29 logistic AGE:SEX Ml vs no Ml (follow-up) 3 0.0001753 1.39 rs17027580 58.29 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.00019 1.39 rs17027581 58.29 logistic Ml vs no Ml (at entry) 3 0.000117 1.39 rs17027581 58.29 logistic Ml vs no Ml (follow-up) 3 0.0001272 1.38 rs17027581 58.29 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0001764 1.39 rs17027581 58.29 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0001913 1.38 rs17027581 58.29 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.000197 1.39 rs17027581 58.29 logistic AGEiSEX Ml vs no Ml (follow-up) 3 0.0002029 1.38 rs170286 80.71 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0001679 0.65 rs170286 80.71 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0001809 0.65 rs170286 80.71 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0002414 0.65 rs170286 80.71 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.000242 0.65 rs170286 80.71 logistic AGE:SEX Ml vs no Ml (at entry) 18 0.0003449 0.65 rs17029753 115.58 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0002975 1.33 rs17029754 115.58 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0002065 1.36 rs17031883 116.52 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 0.000344 0.64 rs 17033705 110.31 logistic AGE:SEX Ml vs no Ml (at entry) 12 0.0002893 0.58 rs17033705 110.31 logistic Ml vs no Ml (at entry) 12 0.0003048 0.58 rs17033705 110.31 logistic AGE:SEX Ml vs no Ml (follow-up) 12 0.0003201 0.59 rs17033705 110.31 logistic GE:AGE:SEX Ml vs no Ml (at entry) ^■ 12 0.0003285 0.58 rs17033705 110.31 logistic Ml vs no Ml (follow-up) 12 0.0003425 0.59 rs17033705 110.31 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0003498 0.58 rs17033705 110.31 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0003556 0.59 rs17033705 110.31 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.0003804 0.59 rs17033705 110.31 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.0004762 0.59 rs17035158 148.81 logistic AGE:SEX Ml vs no Ml (follow-up) 1 0.0004452 0.43 rs17035158 148.81 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.000465 0.43 rs17035158 148.81 logistic Ml vs no Ml (follow-up) 1 0.0004815 0.43 rs 17038574 148.55 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 5.02E-05 1.62

rs17038574 148.55 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 0.0002001 1.62 rs17038574 148.55 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.000216 1.55 rs17038574 148.55 logistic Ml vs no Ml (follow-up) 1 0.0004219 1.62 rs17045564 21.84 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 3.60E-05 1.48 rs17045564 21.84 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 6.16E-05 1.53 rs 17045564 21.84 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0001487 1.49 rs17045564 21.84 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0003313 1.53 rs17045564 21.84 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0003476 1.53 rs17045564 21.84 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0003625 1.53 rs 17045564 21.84 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 0.00049 1.39 rs17045568 21.84 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 5.24E-05 1.47 rs17045568 21.84 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.000268 1.46 rs17045568 21.84 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0003404 1.44 rs17045568 21.84 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 0.000421 1.36 rs17056425 66.19 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 9 6.96E-05 1.52 rs17056425 66.19 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 0.000134 1.52 rs17056425 66.19 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 9 0.0001771 1.52 rs17056425 66.19 logistic AGE:SEX Ml vs control (follow-up) 9 0.0002162 1.52 rs17056425 66.19 logistic Ml vs control (follow-up) 9 0.0004182 1.52 rs17056425 66.19 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0004302 1.52 rs17056483 66.20 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 9 4.18E-05 1.53 rs17056483 66.20 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 0.0001404 1.53 rs17056483 66.20 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 9 0.0001861 1.53 rs17056483 66.20 logistic AGE:SEX Ml vs control (follow-up) 9 0.0001964 1.53 rs17056483 66.20 logistic Ml vs control (follow-up) 9 0.0003703 1.53 rs17056483 66.20 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0004126 1.53 rs17060205 76.94 logistic AGEiSEX Ml vs no Ml (at entry) 3 1.20E-05 1.52 rs17060205 76.94 logistic Ml vs no Ml (at entry) 3 2.06E-05 1.52 rs17060205 76.94 logistic AGEiSEX Ml vs no Ml (follow-up) 3 3.25E-05 1.48 rs17060205 76.94 logistic Ml vs no Ml (follow-up) 3 6.07E-05 1.48 rs17060205 76.94 logistic GEiAGEiCRCLiSEX Ml vs no Ml (at entry) 3 8.71 E-05 1.52 rs17060205 76.94 logistic GEIAGEISEX Ml vs no Ml (at entry) 3 8.99E-05 1.52 rs17060205 76.94 logistic GEiAGEiACRiSEX Ml vs no Ml (at entry) 3 0.000149 1.52 rs17060205 76.94 logistic GEIAGEICRCLISEX Ml vs no Ml (follow-up) 3 0.0001706 1.48 rs17060205 76.94 logistic GEIAGEISEX Ml vs no Ml (follow-up) 3 0.0001769 1.48 rs 17060205 76.94 logistic GEIAGEIACRISEX Ml vs no Ml (follow-up) 3 0.00022 1.48

rs17060205 76.94 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0002852 1.52 rs17060235 76.95 logistic AGE:SEX Ml vs no Ml (at entry) 3 1.84E-05 1.44 rs17060235 76.95 logistic Ml vs no Ml (at entry) 3 2.21 E-05 1.44 rs17060235 76.95 logistic AGE:SEX Ml vs no Ml (follow-up) 3 2.47E-05 1.43 rs17060235 76.95 logistic Ml vs no Ml (follow-up) 3 3.11 E-05 1.43 rs 17060235 76.95 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 5.17E-05 1.44 rs17060235 76.95 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 5.88E-05 1.43 rs17060235 76.95 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 6.80E-05 1.44 rs17060235 76.95 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 7.63E-05 1.43 rs17060235 76.95 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 0.000189 1.43 rs17060235 76.95 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0002086 1.44 rs17060235 76.95 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0002437 1.43 rs17060235 76.95 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0002457 1.44 rs17060302 76.96 logistic Ml vs no Ml (at entry) 3 5.30E-05 1.58 rs17060302 76.96 logistic AGE:SEX Ml vs no Ml (at entry) 3 7.22E-05 1.58 rs17060302 76.96 logistic Ml vs no Ml (follow-up) 3 0.0001877 1.52 rs17060302 76.96 logistic AGE:SEX Ml vs no Ml (follow-up) 3 0.00026 1.52 rs17060302 76.96 logistic Ml vs control (at entry) 3 0.0004554 1.70

4-

O rs17060302 76.96 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0004647 1.58 rs17060302 76.96 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0004956 1.58 rs17064344 81.61 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0002206 1.86 rs17064344 81.61 logistic AGE:SEX Ml vs control (at entry) 18 0.0002385 1.86 rs17064344 81.61 logistic Ml vs control (at entry) 18 0.0003432 1.86 rs17064344 81.61 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0003806 1.86 rs17070608 142.07 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0001968 0.58 rs17070608 142.07 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0002016 0.58 rs17070608 142.07 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0002329 0.58 rs17070608 142.07 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 0.0002435 0.58 rs17070608 142.07 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0003253 0.60 rs17070608 142.07 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0003521 0.60 rs17070608 142.07 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0003993 0.60 rs17070608 142.07 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0004245 0.60 rs17072025 6.07 logistic AGE:SEX Ml vs control (follow-up) 8 8.27E-06 1.83 rs17072025 6.07 logistic Ml vs control (follow-up) 8 1.21 E-05 1.83 rs17072025 6.07 logistic AGE:SEX Ml vs no Ml (follow-up) 8 1.30E-05 1.47 rs17072025 6.07 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 1.33E-05 1.83

rs17072025 6.07 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 1.40E-05 1.47 rs17072025 6.07 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 8 1.42E-05 1.83 rs17072025 6.07 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 1.89E-05 1.47 rs17072025 6.07 logistic Ml vs no Ml (follow-up) 8 2.19E-05 1.47 rs17072025 6.07 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 2.26E-05 1.47 rs17072025 6.07 logistic AGEiSEX Ml vs no Ml (at entry) 8 2.34E-05 1.47 rs17072025 6.07 logistic GE:AGE:SEX Ml vs control (follow-up) 8 2.71 E-05 1.83 rs17072025 6.07 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 8 3.08E-05 1.47 rs17072025 6.07 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 3.41 E-05 1.47 rs17072025 6.07 logistic Ml vs no Ml (at entry) 8 3.51 E-05 1.47 rs17072025 6.07 logistic AGE:SEX Ml vs control (at entry) 8 4.71 E-05 1.62 rs17072025 6.07 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 8 4.99E-05 1.83 rs17072025 6.07 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 5.67E-05 1.47 rs17072025 6.07 logistic GE:AGE:SEX Ml vs control (at entry) 8 6.37E-05 1.62 rs17072025 6.07 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 7.06E-05 1.47 rs17072025 6.07 logistic Ml vs control (at entry) 8 7.47E-05 1.62 rs 17072025 6.07 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 8 9.49E-05 1.62 rs17072025 6.07 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 8 0.0001261 1.62 rs17072025 6.07 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0001322 1.47 rs17072025 6.07 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 0.0001721 1.62 rs17075007 179.42 logistic AGE:SEX Ml vs control (follow-up) 5 3.55E-05 1.60 rs17075007 179.42 logistic Ml vs control (follow-up) 5 6.18E-05 1.60 rs17075007 179.42 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 5 0.0001122 1.60 rs17075007 179.42 logistic GE:AGE:SEX Ml vs control (follow-up) 5 0.0001578 1.60 rs17075007 179.42 logistic AGE:SEX Ml vs control (at entry) 5 0.0001605 1.47 rs17075007 179.42 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.0001635 1.35 rs17075007 179.42 logistic Ml vs control (at entry) 5 0.0002228 1.47 rs17075007 179.42 logistic Ml vs no Ml (follow-up) 5 0.0002409 1.35 rs17075007 179.42 logistic AGE:SEX Ml vs no Ml (at entry) 5 0.000306 1.33 rs17075007 179.42 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0003071 1.35 rs17075007 179.42 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0003229 1.35 rs17075007 179.42 logistic Ml vs no Ml (at entry) 5 0.0004149 1.33 rs17081619 105.05 logistic Ml vs no Ml (at entry) 18 7.04E-06 0.51 rs17081619 105.05 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 7.62E-06 0.51 rs17081619 105.05 logistic AGE:SEX Ml vs no Ml (at entry) 18 1.45E-05 0.51 rs17081619 105.05 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 2.06E-05 0.51

rs17081619 105.05 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 2.89E-05 0.51 rs17081619 105.05 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 4.88E-05 0.51 rs17081619 105.05 logistic Ml vs no Ml (follow-up) 18 8.17E-05 0.57 rs17081619 105.05 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 0.0001187 0.57 rs17081619 105.05 logistic AGE:SEX Ml vs no Ml (follow-up) 18 0.0001815 0.57 rs17081619 105.05 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0002292 0.57 rs17081619 105.05 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 0.0003057 0.57 rs17081709 11.52 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 13 5.76E-05 1.53 rs17081709 11.52 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 13 0.0002834 1.47 rs17081709 11.52 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 13 0.0002996 1.53 rs17081709 11.52 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 0.000381 1.53 rs17088990 45.46 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 13 0.0004103 1.36 rs17090075 77.14 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 18 0.000126 1.87 rs17090075 77.14 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 18 0.0002738 1.57 rs17090089 77.14 logistic GE:AGE:SEX Ml vs control (follow-up) 18 0.0001862 2.00 rs17090089 77.14 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 0.0001983 2.00 rs17090089 77.14 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 18 0.0002326 2.00 _w rs17090089 77.14 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 18 0.0002797 1.79

£ rs17090089 77.14 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0004218 1.79 rs17090089 77.14 logistic AGE:SEX Ml vs control (follow-up) 18 0.0004491 2.00 rs17090089 77.14 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0004521 1.79 rs17093383 114.69 logistic Ml vs control (follow-up) 14 0.000247 0.69 rs17093383 114.69 logistic AGE:SEX Ml vs control (follow-up) 14 0.0004153 0.69 rs17094227 57.09 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 1.60E-05 0.31 rs17094227 57.09 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 1.75E-05 0.31 rs17094227 57.09 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 1.80E-05 0.31 rs17094227 57.09 logistic Ml vs no Ml (at entry) 12 2.41 E-05 0.31 rs17094227 57.09 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 4.04E-05 0.35 rs17094227 57.09 logistic AGE:SEX Ml vs no Ml (at entry) 12 4.12E-05 0.31 rs17094227 57.09 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 4.15E-05 0.31 rs17094227 57.09 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 4.56E-05 0.35 rs17094227 57.09 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 5.16E-05 0.35 rs17094227 57.09 logistic Ml vs no Ml (follow-up) 12 5.39E-05 0.35 rs17094227 57.09 logistic AGE:SEX Ml vs no Ml (follow-up) 12 0.0001042 0.35 rs17094227 57.09 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.0001163 0.35 rs17099196 140.52 logistic AGEiSEX Ml vs no Ml (at entry) 10 0.0004341 1.58

rs17099254 74.61 logistic AGE:SEX Ml vs control (follow-up) 12 0.0001978 0.67 rs17099254 74.61 logistic AGE:SEX Ml vs control (at entry) 12 0.0004421 0.70 rs17104962 43.13 logistic GE:AGE:SEX Ml vs no Ml (at entry) 14 1.63E-06 0.11 rs17104962 43.13 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 14 2.13E-06 0.11 rs17104962 43.13 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 14 2.17E-06 0.11 rs17104962 43.13 logistic Ml vs no Ml (at entry) 14 2.25E-06 0.11 rs17104962 43.13 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 14 3.55E-06 0.11 rs17104962 43.13 logistic AGE:SEX Ml vs no Ml (at entry) 14 3.99E-06 0.11 rs17104962 43.13 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 14 7.04E-06 0.22 rs17104962 43.13 logistic Ml vs no Ml (follow-up) 14 7.24E-06 0.22 rs17104962 43.13 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 14 1.04E-05 0.22 rs17104962 43.13 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 14 1.13E-05 0.22 rs17104962 43.13 logistic AGE:SEX Ml vs no Ml (follow-up) 14 1.80E-05 0.22 rs17104962 43.13 logistic GE:AGE:SEX Ml vs control (at entry) 14 2.07E-05 0.14 rs17104962 43.13 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 14 3.14E-05 0.22 rs17104962 43.13 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 14 3.83E-05 0.14 rs17104962 43.13 logistic AGE:SEX Ml vs control (at entry) 14 4.84E-05 0.14 _w rs17104962 43.13 logistic Ml vs control (at entry) 14 4.93E-05 0.14

6 rs17104962 43.13 logistic GE:AGE:SEX Ml vs control (follow-up) 14 0.0001849 0.25 rs17104962 43.13 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 14 0.0002235 0.14 rs17104962 43.13 logistic Ml vs control (follow-up) 14 0.0002811 0.25 rs17104962 43.13 logistic AGE:SEX Ml vs control (follow-up) 14 0.0002831 0.25 rs17104962 43.13 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 14 0.0003507 0.25 rs17105368 147.64 logistic Ml vs control (follow-up) 10 0.0002531 1.84 rs17105368 147.64 logistic AGE:SEX Ml vs control (follow-up) 10 0.0002569 1.84 rs17113360 126.32 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.0001807 1.48 rs17113360 126.32 logistic AGE:SEX Ml vs no Ml (follow-up) ^■ 1 0.0002291 1.48 rs17113360 126.32 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 0.000231 1.48 rs17113360 126.32 logistic Ml vs no Ml (follow-up) 1 0.0003026 1.48 rs17113360 126.32 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 0.0003055 1.46 rs17113360 126.32 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0003314 1.48 rs17113360 126.32 logistic AGE:SEX Ml vs no Ml (at entry) 1 0.0003745 1.46 rs17113360 126.32 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0004035 1.48 rs17113360 126.32 logistic Ml vs no Ml (at entry) 1 0.0004607 1.46 rs17113360 126.32 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 0.0004939 1.46 rs17113374 126.32 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.0001577 1.49

rs17113374 126.32 logistic AGE:SEX Ml vs no Ml (follow-up) 1 0.0001699 1.49 rs17113374 126.32 logistic Ml vs no Ml (follow-up) 1 0.0002237 1.49 rs17113374 126.32 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0002886 1.49 rs17113374 126.32 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0003182 1.49 rs17113374 126.32 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 0.0003372 1.49 rs17113374 126.32 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 0.000393 1.46 rs17113374 126.32 logistic AGE:SEX Ml vs no Ml (at entry) 1 0.0003984 1.46 rs17113374 126.32 logistic Ml vs no Ml (at entry) 1 0.0004851 1.46 rs17114146 124.33 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 6.29E-05 0.56 rs17114146 124.33 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 9.40E-05 0.56 rs17114146 124.33 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0003273 0.56 rs17114146 124.33 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 0.0004547 0.56 rs17119981 71.62 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 6.94E-07 1.48 rs17119981 71.62 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 2.96E-05 1.42 rs17124993 68.03 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 0.0004335 1.67 rs17126675 97.80 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 2.38E-05 0.62 rs17126675 97.80 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0001215 0.65 rs17126675 97.80 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 0.0001544 0.62 rs17126675 97.80 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.000183 0.62 rs17126675 97.80 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.0002163 0.62 rs17126675 97.80 logistic AGEiSEX Ml vs no Ml (follow-up) 1 0.000239 0.62 rs17132450 162.84 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 0.0004449 0.81 rs17151591 39.93 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 7 0.0004335 1.33 rs17151705 40.00 logistic AGE:SEX Ml vs control (follow-up) 7 0.0003194 0.38 rs17154998 120.64 logistic GE:AGE:SEX Ml vs no Ml (at entry) 7 1.84E-06 0.12 rs17154998 120.64 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 7 2.07E-06 0.12 rs17154998 120.64 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 7 2.14E-06 0.12 rs17154998 120.64 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 7 2.83E-06 0.12 rs17154998 120.64 logistic Ml vs no Ml (at entry) 7 3.40E-06 0.12 rs17154998 120.64 logistic AGE:SEX Ml vs no Ml (at entry) 7 5.64E-06 0.12 rs17154998 120.64 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 1.92E-05 0.26 rs17154998 120.64 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 2.42E-05 0.26 rs17154998 120.64 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 2.52E-05 0.26 rs17154998 120.64 logistic Ml vs no Ml (follow-up) 7 2.60E-05 0.26 rs17154998 120.64 logistic GE:AGE:SEX Ml vs control (at entry) 7 5.85E-05 0.16 rs17154998 120.64 logistic ' AGE:SEX Ml vs no Ml (follow-up) 7 5.86E-05 0.26

rs17154998 120.64 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 7 7.02E-05 0.26 rs17154998 120.64 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 7.19E-05 0.16 rs17154998 120.64 logistic Ml vs control (at entry) 7 0.0001656 0.16 rs17154998 120.64 logistic AGE:SEX Ml vs control (at entry) 7 0.0002003 0.16 rs17156145 110.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0003193 1.22 rs17171382 141.44 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 5 6.22E-05 1.75 rs17171382 141.44 logistic AGE:SEX Ml vs control (follow-up) 5 0.0001446 1.75 rs17171382 141.44 logistic GE:AGE:SEX Ml vs control (follow-up) 5 0.0002003 1.75 rs17171382 141.44 logistic Ml vs control (follow-up) 5 0.0002389 1.75 rs17171382 141.44 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 5 0.0002452 1.75 rs17172953 156.05 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.0004775 1.58 rs17183465 118.65 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 4.38E-05 0.76 rs17183465 118.65 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.0001708 0.79 rs17191463 53.30 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 15 0.0001128 1.42 rs17191463 53.30 logistic AGE:SEX Ml vs no Ml (at entry) 15 0.0002309 1.42 rs17191463 53.30 logistic Ml vs no Ml (at entry) 15 0.0002676 1.42 rs17191463 53.30 logistic GE:AGE:SEX Ml vs no Ml (at entry) 15 0.0002678 1.42 _w rs17191463 53.30 logistic GE:AGE:CRCL:SEX Ml vs no MJ (at entry) 15 0.0002907 1.42

£ rs17191463 53.30 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 15 0.0003146 1.43 rs17191463 53.30 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 15 0.0004624 1.48 rs17207852 3.96 logistic Ml vs no Ml (follow-up) 21 1.00E-04 0.60 rs17207852 3.96 logistic AGE:SEX Ml vs no Ml (follow-up) 21 0.0001543 0.60 rs17207852 3.96 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 21 0.000161 0.60 rs17207852 3.96 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 21 0.0002709 0.60 rs 17207852 3.96 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 21 0.0002742 0.60 rs17214746 167.34 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 0.0001858 1.39 rs17229383 188.00 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 5 0.0003874 1.80 rs17259942 85.02 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0004137 0.70 rs17259942 85.02 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0004196 0.70 rs1726254 140.13 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 12 6.15E-05 1.43 rs17282551 151.47 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0002038 0.65 rs17282551 151.47 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0002202 0.65 rs17282551 151.47 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0002434 0.66 rs17282551 151.47 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0002737 0.65 rs17282551 151.47 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0002884 0.66 rs17282551 151.47 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 0.0003222 0.66

rs 17282551 151.47 logistic Ml vs no Ml (at entry) 3 0.0003272 0.65 rs17282551 151.47 logistic Ml vs no Ml (follow-up) 3 0.0003343 0.66 rs17282551 151.47 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0004478 0.65 rs17282551 151.47 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.000451 0.65 rs17282551 151.47 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 0.0004585 0.66 rs17282551 151.47 logistic AGE:SEX Ml vs no Ml (follow-up) 3 0.0004906 0.66 rs17296210 238.34 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0002011 1.26 rs 17296210 238.34 logistic GE:AGE:SEX Ml vs control (follow-up) 2 0.0004298 1.34 rs17303597 61.85 logistic AGE:SEX Ml vs no Ml (at entry) 8 2.33E-05 1.33 rs17303597 61.85 logistic AGE:SEX Ml vs no Ml (follow-up) 8 4.74E-05 1.31 rs17303597 61.85 logistic AGEiSEX Ml vs control (at entry) 8 6.95E-05 1.41 rs17303597 61.85 logistic Ml vs no Ml (at entry) 8 7.90E-05 1.33 rs17303597 61.85 logistic Ml vs control (at entry) 8 0.0001532 1.41 rs17303597 61.85 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 0.0001572 1.33 rs17303597 61.85 logistic Ml vs no Ml (follow-up) 8 0.0001897 1.31 rs17303597 61.85 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0002638 1.33 rs17303597 61.85 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0002962 1.33

^ rs17303597 61.85 logistic AGEiSEX Ml vs control (follow-up) 8 0.0003615 1.38

£ rs17303597 61.85 logistic GEiAGEiACRiSEX Ml vs no Ml (follow-up) 8 0.0003713 1.31 rs17303597 61.85 logistic GEIAGEISEX Ml vs no Ml (follow-up) 8 0.00038 1.31 rs17303597 61.85 logistic GEiAGEiCRCLiSEX Ml vs no Ml (follow-up) 8 0.0004304 1.31 rs17309228 39.92 logistic GEiAGEiCRCLiSEX Ml vs control (at entry) 7 0.0003867 0.72 rs17309228 39.92 logistic GEIAGEISEX Ml vs control (at entry) 7 0.0004047 0.72 rs17328164 57.62 logistic AGEISEX Ml vs control (follow-up) 19 0.0002512 0.55 rs17328164 57.62 logistic AGEiSEX Ml vs control (at entry) 19 0.0003973 0.56 rs17334370 109.06 logistic Ml vs no Ml (follow-up) 5 1.55E-17 0.36 rs17334370 109.06 logistic AGEiSEX Ml vs no Ml (follow-up) 5 2.60E-17 0.36 rs17334370 109.06 logistic Ml vs no Ml (at entry) 5 8.60E-17 0.36 rs17334370 109.06 logistic AGEiSEX Ml vs no Ml (at entry) 5 1.40E-16 0.36 rs17334370 109.06 logistic GEIAGEISEX Ml vs no Ml (follow-up) 5 2.28E-16 0.36 rs17334370 109.06 logistic GEIAGEICRCLISEX Ml vs no Ml (follow-up) 5 7.38E-16 0.36 rs17334370 109.06 logistic GEIAGEISEX Ml vs no Ml (at entry) 5 1.53E-15 0.36 rs17334370 109.06 logistic GEIAGEICRCLISEX Ml vs no Ml (at entry) 5 4.97E-15 0.36 rs17334370 109.06 logistic GEIAGEIACRISEX Ml vs no Ml (follow-up) 5 3.68E-14 0.36 rs17334370 109.06 logistic GEIAGEIACRISEX Ml vs no Ml (at entry) 5 1.32E-13 0.36 rs17334370 109.06 logistic Ml vs control (at entry) 5 1.05E-12 0.37

rs17334370 109.06 logistic AGE:SEX Ml vs control (at entry) 5 2.24E-12 0.37 rs 17334370 109.06 logistic Ml vs control (follow-up) 5 1.50E-11 0.37 rs17334370 109.06 logistic AGE:SEX Ml vs control (follow-up) 5 2.91 E-11 0.37 rs17334370 109.06 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 2.99E-11 0.37 rs17334370 109.06 logistic GE:AGE:SEX Ml vs control (at entry) 5 3.62E-11 0.37 rs17334370 109.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 6.24E-11 0.36 rs17334370 109.06 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 2.13E-10 0.37 rs17334370 109.06 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 5 2.28E-10 0.37 rs17334370 109.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 3.01 E-10 0.36 rs17334370 109.06 logistic GE:AGE:SEX Ml vs control (follow-up) 5 3.47E-10 0.37 rs17334370 109.06 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 5 1.22E-09 0.37 rs17343615 37.95 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 5 0.000222 1.56 rs17343615 37.95 logistic AGE:SEX Ml vs control (follow-up) 5 0.0002899 1.68 rs17343615 37.95 logistic Ml vs control (follow-up) 5 0.0002988 1.68 rs17343615 37.95 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 5 0.000372 1.68 rs17343615 37.95 logistic AGE:SEX Ml vs control (at entry) 5 0.0003967 1.56 rs17343615 37.95 logistic GE:AGE:SEX Ml vs control (follow-up) 5 0.0004608 1.68 rs17343615 37.95 logistic Ml vs control (at entry) 5 0.0004845 1.56

4- rs1735512 27.41 logistic GE:AGE:SEX Ml vs control (at entry) 21 0.0001716 1.32 rs1735512 27.41 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 21 0.0003984 1.32 rs17368812 87.54 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 13 0.0003426 1.26 rs17371162 26.04 logistic GE:AGE:SEX Ml vs control (at entry) 6 0.0002009 0.70 rs17371162 26.04 logistic AGEiSEX Ml vs control (at entry) 6 0.0002013 0.70 rs17371162 26.04 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 6 0.0003655 0.70 rs17371162 26.04 logistic Ml vs control (at entry) 6 0.0004896 0.70 rs17387008 130.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0002048 1.45 rs17387008 130.06 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 9 0.0003651 1.45 rs17387008 130.06 logistic GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0004394 1.45 rs17391002 67.06 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0001687 1.34 rs17391002 67.06 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0002494 1.34 rs17391002 67.06 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.000305 1.34 rs17391002 67.06 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 0.0003557 1.34 rs17391002 67.06 logistic Ml vs no Ml (follow-up) 10 0.0003638 1.34 rs17394217 99.40 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0004156 1.39 rs17428956 82.91 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0003583 1.34 rs 17435665 87.59 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 13 0.0001005 1.78

rs17444745 124.28 logistic AGE:SEX Ml vs control (at entry) 16 0.0002918 0.68 rs17444745 124.28 logistic AGE:SEX Ml vs no Ml (at entry) 16 0.0004211 0.71 rs17444745 124.28 logistic Ml vs no Ml (at entry) 16 0.0004846 0.71 rs17459837 214.75 logistic Ml vs no Ml (follow-up) 1 1.97E-05 1.80 rs17459837 214.75 logistic Ml vs no Ml (at entry) 1 2.04E-05 1.81 rs17459837 214.75 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 2.54E-05 1.80 rs17459837 214.75 logistic AGE:SEX Ml vs no Ml (at entry) 1 3.25E-05 1.81 rs17459837 214.75 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 3.39E-05 1.81 rs17459837 214.75 logistic AGE:SEX Ml vs no Ml (follow-up) 1 3.41 E-05 1.80 rs17459837 214.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 4.34E-05 1.81 rs17459837 214.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 4.38E-05 1.80 rs17459837 214.75 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 6.24E-05 1.80 rs17459837 214.75 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 6.28E-05 1.81 rs17459837 214.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0002679 1.80 rs17459837 214.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0002739 1.81 rs17459837 214.75 logistic Ml vs control (at entry) 1 0.000388 1.95 rs17477680 116.26 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 4.35E-05 1.54 rs17477680 116.26 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 5.63E-05 1.54 rs17477680 116.26 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 0.0001151 1.50 rs17477680 116.26 logistic Ml vs no Ml (follow-up) 8 0.0001333 1.54 rs17477680 116.26 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0001385 1.50 rs17477680 116.26 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0001386 1.54 rs17477680 116.26 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 8 0.0002128 1.54 rs17477680 116.26 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0003085 1.50 rs17477680 116.26 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.000342 1.54 rs17477680 116.26 logistic Ml vs no Ml (at entry) 8 0.00038 1.50 rs17477680 116.26 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0004779 1.50 rs17484259 148.33 logistic Ml vs control (at entry) 4 0.0003668 0.68 rs17560858 70.44 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0001286 0.61 rs17560858 70.44 logistic Ml vs no Ml (at entry) 1 0.0002767 0.61 rs17560858 70.44 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 0.0003159 0.61 rs17560858 70.44 logistic AGEiSEX Ml vs no Ml (at entry) 1 0.0004095 0.61 rs17560858 70.44 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0004418 0.64 rs17560858 70.44 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 0.000457 0.61 rs17564220 97.49 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 0.0001094 1.34 rs17564220 97.49 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 13 0.0001382 1.34

rs 17564220 97.49 logistic AGE:SEX Ml vs no Ml (at entry) 13 0.0001798 1.34 rs17564220 97.49 logistic Ml vs no Ml (at entry) 13 0.0003234 1.34 rs 17564220 97.49 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 13 0.0003825 1.29 rs17567053 39.67 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0002019 1.26 rs17567053 39.67 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.0003872 1.26 rs 17567053 39.67 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0004767 1.26 rs17573753 92.15 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0002204 1.26 rs17601491 207.40 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 3.30E-05 0.49 rs17601491 207.40 logistic Ml vs no Ml (at entry) 1 3.60E-05 0.49 rs17601491 207.40 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 4.35E-05 0.49 rs17601491 207.40 logistic AGE:SEX Ml vs no Ml (at entry) 1 6.75E-05 0.49 rs17601491 207.40 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 8.74E-05 0.49 rs17601491 207.40 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0001054 0.49 rs17601491 207.40 logistic Ml vs no Ml (follow-up) 1 0.0003062 0.56 rs17601491 207.40 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 0.0003857 0.56 rs17601491 207.40 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0004053 0.56 rs17602774 77.05 logistic Ml vs control (follow-up) 18 0.0001252 0.66 rs17602774 77.05 logistic AGE:SEX Ml vs control (follow-up) 18 0.0001456 0.66

4- rs17602774 77.05 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 0.0001717 0.66 rs 17602774 77.05 logistic GE:AGE:SEX Ml vs control (follow-up) 18 0.0003496 0.66 rs17609346 60.50 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0001011 0.61 rs17609346 60.50 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0001293 0.61 rs17609346 60.50 logistic Ml vs no Ml (at entry) 4 0.0001758 0.61 rs17609346 60.50 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0003009 0.61 rs17609346 60.50 logistic AGE:SEX Ml vs no Ml (at entry) 4 0.000304 0.61 rs17609346 60.50 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0003266 0.61 rs17609346 60.50 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0004817 0.65 rs17647040 45.39 logistic Ml vs no Ml (follow-up) 15 0.0004541 1.31 rs 17647607 7.75 logistic Ml vs no Ml (follow-up) 18 0.0002723 1.35 rs17647607 7.75 logistic Ml vs no Ml (at entry) 18 0.0002742 1.35 rs17674783 66.60 logistic Ml vs control (follow-up) 8 0.0001545 0.64 rs17674783 66.60 logistic AGE:SEX Ml vs control (follow-up) 8 0.0003039 0.64 rs17674783 66.60 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.0003344 0.64 rs17674783 66.60 logistic Ml vs control (at entry) 8 0.0003622 0.67 rs17675026 66.61 logistic Ml vs control (follow-up) 8 0.0001225 0.64 rs17675026 66.61 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.0002172 0.64

rs17675026 66.61 logistic AGE:SEX Ml vs control (follow-up) 8 0.0002341 0.64 rs17675026 66.61 logistic Ml vs control (at entry) 8 0.0002798 0.67 rs17680407 43.28 logistic AGEiSEX Ml vs control (follow-up) 4 7.12E-05 0.68 rs17680407 43.28 logistic Ml vs control (follow-up) 4 0.0002619 0.68 rs17680407 43.28 logistic GE:AGE:SEX Ml vs control (follow-up) 4 0.0002987 0.68 rs17680407 43.28 logistic AGE:SEX Ml vs control (at entry) 4 0.0004107 0.72 rs17680407 43.28 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0004282 0.68 rs17680905 43.28 logistic AGE:SEX Ml vs control (follow-up) 4 5.96E-05 0.68 rs17680905 43.28 logistic Ml vs control (follow-up) 4 0.0002255 0.68 rs17680905 43.28 logistic GE:AGE:SEX Ml vs control (follow-up) 4 0.000259 0.68 rs17680905 43.28 logistic AGE:SEX Ml vs control (at entry) 4 0.0003059 0.71 rs17680905 43.28 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0003735 0.68 rs17692461 91.03 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0004477 1.30 rs17736364 106.01 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 8 0.0002126 0.67 rs17736364 106.01 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 8 0.0002907 0.67 rs17748393 107.31 logistic AGE:SEX Ml vs control (at entry) 3 0.0004391 0.72 rs17750221 63.46 logistic GE:AGE:SEX Ml vs control (at entry) 4 0.0001042 1.37 rs17750221 63.46 logistic AGE:SEX Ml vs control (at entry) 4 0.0001649 1.37

Ul

O rs17750221 63.46 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 4 0.0002358 1.37 rs 17750221 63.46 logistic Ml vs control (at entry) 4 0.000243 1.37 rs17750246 63.47 logistic GE:AGE:SEX Ml vs control (at entry) 4 9.91 E-05 1.37 rs17750246 63.47 logistic AGEiSEX Ml vs control (at entry) 4 0.0001599 1.37 rs17750246 63.47 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 4 0.0002245 1.37 rs 17750246 63.47 logistic Ml vs control (at entry) 4 0.000236 1.37 rs17750253 125.25 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 4.48E-06 0.39 rs17750253 125.25 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 1.02E-05 0.39 rs 17750253 125.25 logistic Ml vs no Ml (at entry) 8 1.22E-05 0.39 rs17750253 125.25 logistic AGE:SEX Ml vs no Ml (at entry) 8 1.91 E-05 0.39 rs 17750253 125.25 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 2.03E-05 0.39 rs17750253 125.25 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 3.92E-05 0.39 rs17750253 125.25 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 8.66E-05 0.47 rs 17750253 125.25 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.000145 0.47 rs17750253 125.25 logistic Ml vs no Ml (follow-up) 8 0.0001499 0.47 rs17750253 125.25 logistic GE:AGE:SEX Ml vs control (at entry) 8 0.0001848 0.41 rs17750253 125.25 logistic Ml vs control (at entry) 8 0.000246 0.41 rs17750253 125.25 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0002467 0.47

rs17750253 125.25 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 8 0.0002732 0.47 rs17750253 125.25 logistic AGE:SEX Ml vs control (at entry) 8 0.0002773 0.41 rs17753899 142.43 logistic AGE:SEX Ml vs control (follow-up) 3 0.0003766 0.60 rs1775401 11.43 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 8.01 E-05 0.77 rs17763040 25.45 logistic AGE:SEX Ml vs control (follow-up) 13 0.0004486 0.63 rs17763040 25.45 logistic Ml vs control (follow-up) 13 0.0004521 0.63 rs17763040 25.45 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 13 0.0004924 0.63 rs17768420 102.24 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0003461 0.76 rs17768420 102.24 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0004041 0.76 rs17768420 102.24 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 0.0004069 0.76 rs17768420 102.24 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 8 0.000433 0.77 rs 17768420 102.24 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0004963 0.77 rs17774514 54.94 logistic AGE:SEX Ml vs control (follow-up) 19 0.0004612 0.70 rs17781350 71.22 logistic Ml vs control (follow-up) 15 0.0002354 0.27 rs17781350 71.22 logistic AGE:SEX Ml vs control (follow-up) 15 0.0002612 0.27 rs17781350 71.22 logistic Ml vs control (at entry) 15 0.0003962 0.29 rs17781350 71.22 logistic AGE:SEX Ml vs control (at entry) 15 0.0004076 0.29

_K , rs17783776 47.99 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0003798 0.74

2 rs17796589 63.62 logistic Ml vs control (follow-up) 14 0.0002019 1.64 rs17796589 63.62 logistic AGE:SEX Ml vs control (follow-up) 14 0.0003784 1.64 rs17806588 103.71 logistic Ml vs control (follow-up) 6 0.0004326 2.53 rs17806588 103.71 logistic AGE:SEX Ml vs control (follow-up) 6 0.0004551 2.53 rs17807662 117.82 logistic Ml vs control (follow-up) 9 0.0001346 0.42 rs 17807662 117.82 logistic AGE:SEX Ml vs control (follow-up) 9 0.0002691 0.42 rs17815316 113.69 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 0.0002008 1.27 rs17820836 13.66 logistic GE:AGE:SEX Ml vs control (at entry) 22 7.46E-05 0.66 rs17820836 13.66 logistic AGE:SEX Ml vs control (at entry) 22 7.95E-05 0.66 rs17820836 13.66 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 22 7.97E-05 0.66 rs17820836 13.66 logistic Ml vs control (at entry) 22 0.0001618 0.66 rs17825174 58.10 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 16 0.0004803 0.63 rs17826186 188.00 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 5 0.0003874 1.78 rs17836256 75.33 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 14 0.0004142 1.49 rs17836256 75.33 logistic GE:AGE:SEX Ml vs control (at entry) 14 0.0004499 1.49 rs17836431 69.37 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 10 5.10E-05 1.95 rs17836431 69.37 logistic Ml vs control (follow-up) 10 0.000491 1.95 rs17838321 141.37 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 9.46E-06 1.71

rs17838321 141.37 logistic AGEiSEX Ml vs no WlI (at entry) 1 2.14E-05 1.71 rs17838321 141.37 logistic Ml vs no Ml (at entry) 1 2.77E-05 1.71 rs17838321 141.37 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 2.81 E-05 1.71 rs17838321 141.37 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 3.63E-05 1.71 rs17838321 141.37 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 4.09E-05 1.71 rs17838321 141.37 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 5.90E-05 1.62 rs17838321 141.37 logistic AGE:SEX Ml vs no Ml (follow-up) 1 0.0001057 1.62 rs17838321 141.37 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.0001397 1.62 rs17838321 141.37 logistic Ml vs no Ml (follow-up) 1 0.0001401 1.62 rs17838321 141.37 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 0.0001556 1.62 rs17838321 141.37 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0001694 1.62 rs17838321 141.37 logistic AGE:SEX Ml vs control (at entry) 1 0.0004157 1.76 rs181930 98.07 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0004552 0.74 rs181930 98.07 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0004687 0.74 rs1821443 92.53 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.000353 0.71 rs1827545 215.42 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0003388 1.25 rs1827546 215.42 logistic GE:AGE:CRCLSEX Ml vs no Ml (at entry) 3 0.0003407 1.25 rs1835742 108.82 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.0002987 0.71

Ul K> rs1835742 108.82 logistic Ml vs control (follow-up) 8 0.0003042 0.71 rs1835742 108.82 logistic AGE:SEX Ml vs control (follow-up) 8 0.0004093 0.71 rs1844261 63.89 logistic Ml vs control (at entry) 12 0.0002287 0.69 rs1844261 63.89 logistic AGE:SEX Ml vs control (at entry) 12 0.0004792 0.69 rs1845624 78.51 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 0.0003563 1.27 rs1845624 78.51 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.0004248 1.27 rs1853772 99.33 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0001142 0.64 rs1853772 99.33 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0001282 0.64 rs1853772 99.33 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 0.0001694 0.62 rs 1853772 99.33 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.0002066 0.62 rs1859898 139.56 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.000156 1.99 rs 1859898 139.56 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0003807 1.99 rs1859898 139.56 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0004293 1.90 rs1861576 159.74 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 5 0.0003372 1.29 rs1862230 95.07 logistic AGE:SEX Ml vs control (at entry) 5 7.97E-06 0.68 rs1862230 95.07 logistic Ml vs control (at entry) 5 1.69E-05 0.68 rs1862230 95.07 logistic GE:AGE:SEX Ml vs control (at entry) 5 7.69E-05 0.68 rs1862230 95.07 logistic AGE:SEX Ml vs control (follow-up) 5 9.65E-05 0.70

rs1862230 95.07 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 0.0001022 0.68 rs1862230 95.07 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0001327 0.77 rs1862230 95.07 logistic AGE:SEX Ml vs no Ml (at entry) 5 0.000239 0.77 rs1862230 95.07 logistic Ml vs control (follow-up) 5 0.000273 0.70 rs1862230 95.07 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.0003534 0.79 rs1862230 . 95.07 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0003896 0.77 rs1862230 95.07 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0003975 0.77 rs1862230 95.07 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 0.0004334 0.68 rs1862230 95.07 logistic Ml vs no Ml (at entry) 5 0.0004702 0.77 rs1866065 118.39 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0002093 1.26 rs1868247 131.28 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0003344 0.63 rs1868247 131.28 logistic GE:AGE:SEX Ml vs control (follow-up) 4 0.0004469 0.63 rs1868248 131.28 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0003344 0.63 rs1868248 131.28 logistic GE:AGE:SEX Ml vs control (follow-up) 4 0.0004469 0.63 rs1868249 131.28 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0003344 0.63 rs1868249 131.28 logistic GE:AGE:SEX Ml vs control (follow-up) 4 0.0004469 0.63 rs1868250 131.28 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0003508 0.63 rs1868250 131.28 logistic GE:AGE:SEX Ml vs control (follow-up) 4 0.0004683 0.63

Ul rs1868727 41.45 logistic GE:AGE:SEX Ml vs no Ml (at entry) 9 2.78E-06 0.19 rs1868727 41.45 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 3.32E-06 0.19 rs1868727 41.45 logistic Ml vs no Ml (at entry) 9 3.77E-06 0.19 rs1868727 41.45 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 9 3.78E-06 0.19 rs1868727 41.45 logistic GE:AGE:ACR:SEX Ml vs no Mi (at entry) 9 3.80E-06 0.19 rs1868727 41.45 logistic AGE:SEX Ml vs no Ml (at entry) 9 7.28E-06 0.19 rs1868727 41.45 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 2.37E-05 0.29 rs1868727 41.45 logistic Ml vs no Ml (follow-up) 9 2.69E-05 0.29 rs1868727 41.45 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 9 3.20E-05 0.29 rs1868727 41.45 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 9 3.53E-05 0.29 rs1868727 41.45 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 4.57E-05 0.29 rs1868727 41.45 logistic AGE:SEX Ml vs no Ml (follow-up) 9 6.53E-05 0.29 rs1868727 41.45 logistic . GE:AGE:SEX Ml vs control (at entry) 9 0.0001939 0.25 rs1868727 41.45 logistic Ml vs control (at entry) 9 0.0003223 0.25 rs1868727 41.45 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 9 0.0003523 0.25 rs1868727 41.45 logistic AGE:SEX Ml vs control (at entry) 9 0.0003951 0.25 rs1869885 81.92 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0003962 1.20 rs1870506 8.86 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 8.39E-05 2.58

rs1875205 17.57 logistic AGE:SEX Ml vs control (at entry) 16 8.02E-05 1.49 rs1875205 17.57 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 16 0.000106 1.36 rs1875205 17.57 logistic AGE:SEX Ml vs no Ml (follow-up) 16 0.0001113 1.36 rs1875205 17.57 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 16 0.0001239 1.49 rs1875205 17.57 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 16 0.0001388 1.36 rs1875205 17.57 logistic Ml vs no Ml (follow-up) 16 0.0001607 1.36 rs1875205 17.57 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 16 0.000213 1.36 rs1875205 17.57 logistic Ml vs control (at entry) 16 0.0002139 1.49 rs1875205 17.57 logistic AGE:SEX Ml vs no Ml (at entry) 16 0.0003505 1.34 rs1875205 17.57 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 16 0.000367 1.34 rs1875205 17.57 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 16 0.000402 1.49 rs1875205 17.57 logistic Ml vs no Ml (at entry) 16 0.0004593 1.34 rs1876681 62.43 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 0.0001241 1.55 rs1876681 62.43 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 0.000328 1.55 rs1876681 62.43 logistic Ml vs control (at entry) 5 0.0003796 1.55 rs1876681 62.43 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 5 0.0003846 1.57 rs1876681 62.43 logistic AGE:SEX Ml vs control (at entry) 5 0.0004281 1.55 _w rs1876681 62.43 logistic GE:AGE:SEX Ml vs control (at entry) 5 0.0004418 1.55

£ rs1876852 37.16 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 15 0.0002758 1.30 rs1881441 81.56 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 17 0.0002017 1.29 rs1885290 71.59 logistic Ml vs control (at entry) 20 0.0004425 0.73 rs1885574 38.70 logistic Ml vs no Ml (at entry) 20 6.16E-05 0.68 rs1885574 38.70 logistic GE:AGE:SEX Ml vs no Ml (at entry) 20 7.25E-05 0.68 rs1885574 38.70 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 20 8.50E-05 0.68 rs1885574 38.70 logistic AGE:SEX Ml vs no Ml (at entry) 20 8.69E-05 0.68 rs1885574 38.70 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 0.0001649 0.68 rs1885574 38.70 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 20 0.0002746 0.68 rs1888516 45.60 logistic AGE:SEX Ml vs control (at entry) 21 0.0003407 0.59 rs1888516 45.60 logistic Ml vs control (at entry) 21 0.0004814 0.59 rs188918 70.98 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 7.61 E-05 1.26 rs188918 70.98 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0003198 1.24 rs1895178 165.13 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0002956 0.81 rs1895178 165.13 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.0003032 0.81 rs1918026 63.95 logistic AGE:SEX Ml vs control (follow-up) 3 0.0004101 1.35 rs1918422 81.24 logistic AGE:SEX Ml vs control (at entry) 7 5.69E-05 1.74 rs1918422 81.24 logistic Ml vs control (at entry) 7 8.92E-05 1.74

rs1918422 81.24 logistic AGE:SEX Ml vs control (follow-up) 7 0.0002956 1.74 rs1920584 121.55 logistic AGE:SEX Ml vs no Ml (follow-up) 12 0.0003254 0.79 rs1921589 86.35 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0004253 0.77 rs1921589 86.35 logistic Ml vs no Ml (at entry) 2 0.000493 0.77 rs1924664 80.38 logistic AGE:SEX Ml vs control (follow-up) 6 3.53E-05 0.67 rs1924664 80.38 logistic Ml vs control (follow-up) 6 6.47E-05 0.67 rs1924664 80.38 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 6 0.0003138 0.67 rs1924664 80.38 logistic GE:AGE:SEX Ml vs control (follow-up) 6 0.0003713 0.67 rs1926565 131.18 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 5.78E-05 1.31 rs1926565 131.18 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 8.14E-05 1.31 rs1926565 131.18 logistic Ml vs no Ml (follow-up) 10 9.15E-05 1.31 rs1926565 131.18 logistic AGEiSEX Ml vs no Ml (follow-up) 10 0.0001146 1.31 rs1926565 131.18 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0001299 1.31 rs1926565 131.18 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 0.0002226 1.33 rs1926565 131.18 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 10 0.0002413 1.38 rs1926565 131.18 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0003147 1.31 rs1926565 131.18 logistic GE:AGE:SEX Ml vs control (follow-up) 10 0.0003707 1.38 rs1933035 2.73 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0001317 1.30

Ul rs1933035 2.73 logistic AGE:SEX Ml vs no Ml (at entry) 9 0.0002049 1.30 rs1933035 2.73 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0002059 1.29 rs1933035 2.73 logistic GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0002349 1.30 rs1933035 2.73 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 9 0.000243 1.30 rs1933035 2.73 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 9 0.0002898 1.30 rs1933035 2.73 logistic Ml vs no Ml (at entry) 9 0.0002953 1.30 rs1933035 2.73 logistic AGE:SEX Ml vs no Ml (follow-up) 9 0.0002959 1.29 rs1933035 2.73 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0003361 1.29 rs1933035 2.73 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 9 0.0003664 1.31 rs1933035 2.73 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 9 0.0004162 1.29 rs1933035 2.73 logistic Ml vs no Ml (follow-up) 9 0.00046 1.29 rs1935115 52.52 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 13 0.0003153 1.21 rs1940745 130.20 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0001876 1.18 rs 194781 74.18 logistic Ml vs control (at entry) 14 8.08E-06 1.66 rs194781 74.18 logistic AGE:SEX Ml vs control (at entry) 14 1.67E-05 1.66 rs194781 74.18 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 14 4.49E-05 1.66 rs194781 74.18 logistic GE:AGE:SEX Ml vs control (at entry) 14 5.21 E-05 1.66 rs 194781 74.18 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 14 0.0002178 1.66

rs194781 74.18 logistic Ml vs no Ml (follow-up) 14 0.0002215 1.36 rs194781 74.18 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 14 0.000302 1.36 rs194781 74.18 logistic Ml vs control (follow-up) 14 0.0003267 1.55 rs 194781 74.18 logistic AGE:SEX Ml vs no Ml (follow-up) 14 0.0003482 1.36 rs194781 74.18 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 14 0.0004648 1.36 rs194782 74.18 logistic Ml vs control (at entry) 14 1.52E-05 1.64 rs194782 74.18 logistic AGE:SEX Ml vs control (at entry) 14 3.06E-05 1.64 rs194782 74.18 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 14 7.44E-05 1.64 rs194782 74.18 logistic GE:AGE:SEX Ml vs control (at entry) 14 8.25E-05 1.64 rs194782 74.18 logistic Ml vs no Ml (follow-up) 14 0.0002314 1.36 rs194782 74.18 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 14 0.0002669 1.64 rs194782 74.18 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 14 0.0002989 1.36 rs194782 74.18 logistic Ml vs control (follow-up) 14 0.0003404 1.55 rs194782 74.18 logistic AGE:SEX Ml vs no Ml (follow-up) 14 0.000368 1.36 rs194782 74.18 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 14 0.0004606 1.36 rs1956517 43.33 logistic GE:AGE:SEX Ml vs no Ml (at entry) 14 1.37E-06 0.35 rs1956517 43.33 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 14 2.01 E-06 0.35 rs1956517 43.33 logistic Ml vs no Ml (at entry) 14 2.78E-06 0.35

Ul

Os rs1956517 43.33 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 14 3.22E-06 0.35 rs1956517 43.33 logistic AGE:SEX Ml vs no Ml (at entry) 14 4.48E-06 0.35 rs1956517 43.33 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 14 7.17E-06 0.40 rs1956517 43.33 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 14 1.05E-05 0.40 rs1956517 43.33 logistic Ml vs no Ml (follow-up) 14 1.20E-05 0.40 rs1956517 43.33 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 14 1.78E-05 0.40 rs1956517 43.33 logistic AGEiSEX Ml vs no Ml (follow-up) 14 2.11 E-05 0.40 rs1956517 43.33 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 14 3.52E-05 0.35 rs1956517 43.33 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 14 0.0002275 0.40 rs1957213 44.26 logistic Ml vs no Ml (at entry) 14 0.0004012 1.64 rs1958234 47.84 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 14 1.80E-05 1.42 rs1958234 47.84 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 14 0.0001537 1.27 rs1960385 124.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0001036 1.34 rs1960385 124.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0001406 1.33 rs 1960385 124.19 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.000182 1.34 rs1960385 124.19 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0002344 1.33 rs1960385 124.19 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0004194 1.33 rs1960385 124.19 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0004586 1.34

rs1960385 124.19 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 4 0.0004966 1.38 rs1962196 41.68 logistic AGE:SEX Ml vs control (follow-up) 18 0.000317 0.72 rs1962196 41.68 logistic Ml vs control (follow-up) 18 0.0004987 0.72 rs1963296 31.26 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 17 0.0004837 1.33 rs1963648 124.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0004127 1.31 rs1978718 48.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 19 0.0004764 1.22 rs1979276 45.57 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 17 0.0001814 0.80 rs1980408 45.28 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 21 0.0003862 1.27 rs1982747 97.18 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0002442 1.55 rs1982747 97.18 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0002705 1.55 rs1982747 97.18 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0003611 1.55 rs1983294 112.16 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0003243 0.75 rs1983535 78.84 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0001608 1.39 rs1983535 78.84 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0001785 1.38 rs199031 40.05 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0003026 1.35 rs199031 40.05 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0004725 1.35 rs1990482 17.39 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0001891 0.73 rs1995050 68.87 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 7 0.0002741 1.21

Ul rs1996440 73.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 6.67E-05 1.38 rs1996440 73.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0002929 1.33 rs1999800 45.45 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 13 8.13E-05 1.41 rs2012296 222.15 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 9.91 E-06 0.40 rs2012296 222.15 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 3.21 E-05 0.40 rs2012296 222.15 logistic Ml vs no Ml (at entry) 1 3.40E-05 0.40 rs2012296 222.15 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 4.55E-05 0.40 rs2012296 222.15 logistic AGE:SEX Ml vs no Ml (at entry) 1 7.47E-05 0.40 rs2012296 222.15 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 0.0001252 0.47 rs2012296 222.15 logistic Ml vs no Ml (follow-up) 1 0.0002513 0.47 rs2012296 222.15 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0002975 0.47 rs2012296 222.15 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0003172 0.43 rs2012296 222.15 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.0004123 0.47 rs2013265 47.79 logistic Ml vs no Ml (follow-up) 8 8.44E-06 1.41 rs2013265 47.79 logistic AGE:SEX Ml vs no Ml (follow-up) 8 1.48E-05 1.41 rs2013265 47.79 logistic Ml vs control (follow-up) 8 2.40E-05 1.59 rs2013265 47.79 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 4.53E-05 1.41 rs2013265 47.79 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 8 5.28E-05 1.41

rs2013265 47.79 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 5.38E-05 1.41 rs2013265 47.79 logistic AGE:SEX Ml vs control (follow-up) 8 5.85E-05 1.59 rs2013265 47.79 logistic Ml vs control (at entry) 8 6.76E-05 1.49 rs2013265 47.79 logistic AGE:SEX Ml vs control (at entry) 8 0.0001253 1.49 rs2013265 47.79 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0001456 1.41 rs2013265 47.79 logistic Ml vs no Ml (at entry) 8 0.0001551 1.35 rs2013265 47.79 logistic AGE:SEX Ml vs no Ml (at entry) 8 0.000238 1.35 rs2013265 47.79 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 8 0.0003266 1.59 rs2013265 47.79 logistic GE:AGE:SEX Ml vs control (follow-up) 8 0.0003771 1.59 rs2017914 58.31 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 20 8.16E-05 0.71 rs2017914 58.31 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 0.0001239 0.78 rs2017914 58.31 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 0.0002427 0.80 rs2017914 58.31 logistic GE:AGE:SEX Ml vs control (follow-up) 20 0.0003127 0.71 rs2017914 58.31 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 20 0.0004209 0.71 rs2023120 128.09 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 8 0.0002124 1.45 rs2024476 66.62 logistic Ml vs control (at entry) 16 0.0001472 0.69 rs2024476 66.62 logistic AGE:SEX Ml vs control (at entry) 16 0.000179 0.69 rs2026718 25.82 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 9 0.0001452 1.52

06 rs2026718 25.82 logistic GE:AGE:SEX Ml vs no Ml (at entry) 9 0.000178 1.52 rs2026718 25.82 logistic AGE:SEX Ml vs no Ml (at entry) 9 0.0004749 1.52 rs2026718 25.82 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0004794 1.52 rs2026718 25.82 logistic Ml vs no Ml (at entry) 9 0.0004966 1.52 rs2027714 16.67 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 21 0.0001117 0.60 rs2027714 16.67 logistic GE:AGE:SEX Ml vs no Ml (at entry) 21 0.0002921 0.60 rs2027714 16.67 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 21 0.0003922 0.60 rs2027714 16.67 logistic Ml vs no Ml (at entry) 21 0.0004078 0.60 rs2027714 16.67 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 21 0.0004699 0.60 rs2028100 67.05 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 0.0001221 0.76 rs2028100 67.05 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 0.0002138 0.76 rs2028100 67.05 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0002187 0.76 rs2028100 67.05 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0003333 0.76 rs2028100 67.05 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0003731 0.76 rs2028100 67.05 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0004279 0.76 rs2028100 67.05 logistic Ml vs no Ml (follow-up) 10 0.0004324 0.76 rs2028100 67.05 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.0004554 0.76 rs2029211 116.77 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0002578 0.78

rs2029211 116.77 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0003714 0.78 rs2029211 116.77 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0003978 0.79 rs2029211 116.77 logistic Ml vs no Ml (at entry) 4 0.0004767 0.78 rs2031654 50.97 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 14 0.0003848 0.66 rs2031654 50.97 logistic AGE:SEX Ml vs control (follow-up) 14 0.0004873 0.66 rs2033236 39.64 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0002884 0.80 rs203948 66.74 logistic Ml vs control (at entry) 8 0.0001199 0.63 rs203948 66.74 logistic AGE:SEX Ml vs control (at entry) 8 0.0002292 0.63 rs203948 66.74 logistic Ml vs control (follow-up) 8 0.000326 0.63 rs2048429 99.72 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 19 0.0004183 0.61 rs2052815 132.50 logistic AGE:SEX Ml vs control (follow-up) 2 0.0002575 1.52 rs2052815 132.50 logistic Ml vs control (follow-up) 2 0.0003989 1.52 rs2053553 61.39 logistic Ml vs control (at entry) 9 0.0001948 0.67 rs2053553 61.39 logistic AGE:SEX Ml vs control (at entry) 9 0.0002134 0.67 rs2059601 65.68 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 0.0003461 0.79 rs2059601 65.68 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 0.0004355 0.79 rs2059601 65.68 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0004684 0.79 rs2059601 65.68 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0004847 0.79

Ul rs2061574 80.68 logistic Ml vs control (at entry) 4 0.0004807 0.63 rs2063807 150.05 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.000454 0.73 rs2064947 103.41 logistic Ml vs no Ml (at entry) 6 8.94E-06 0.66 rs2064947 103.41 logistic AGEiSEX Ml vs no Ml (at entry) 6 1.53E-05 0.66 rs2064947 103.41 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 3.00E-05 0.66 rs2064947 103.41 logistic Ml vs no Ml (follow-up) 6 3.31 E-05 0.68 rs2064947 103.41 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 3.52E-05 0.66 rs2064947 103.41 logistic AGE:SEX Ml vs no Ml (follow-up) 6 6.08E-05 0.68 rs2064947 103.41 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001022 0.68 rs2064947 103.41 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.00012 0.68 rs2064947 103.41 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0001415 0.66 rs2064947 103.41 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0001836 0.66 rs2064947 103.41 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0001901 0.68 rs2065903 45.45 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 13 9.26E-05 1.40 rs2069112 90.35 logistic Ml vs no Ml (at entry) 1 3.02E-05 0.57 rs2069112 90.35 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 3.06E-05 0.57 rs2069112 90.35 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 3.08E-05 0.57 rs2069112 90.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 3.23E-05 0.57

rs2069112 90.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 4.92E-05 0.57 rs2069112 90.35 logistic AGE:SEX Ml vs no Ml (at entry) 1 6.96E-05 0.57 rs2069112 90.35 logistic Ml vs no Ml (follow-up) 1 7.08E-05 0.59 rs2069112 90.35 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 9.29E-05 0.59 rs2069112 90.35 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0001084 0.59 rs2069112 90.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 0.0001255 0.59 rs2069112 90.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.0001439 0.59 rs2069112 90.35 logistic AGE:SEX Ml vs no Ml (follow-up) 1 0.0001833 0.59 rs2073302 32.96 logistic GE:AGE:SEX Ml vs control (follow-up) 20 0.0003783 1.41 rs2076355 228.06 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 8.55E-05 1.08 rs2079217 41.79 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 7 0.0002794 0.68 rs2079217 41.79 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0003528 0.68 rs2090974 124.95 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 0.0003576 1.45 rs2090974 124.95 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 0.00044 1.42 rs2092096 103.33 logistic Ml vs no Ml (at entry) 6 2.67E-05 0.67 rs2092096 103.33 logistic AGE:SEX Ml vs no Ml (at entry) 6 4.47E-05 0.67 rs2092096 103.33 logistic Ml vs no Ml (follow-up) 6 6.95E-05 0.69 rs2092096 103.33 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 7.22E-05 0.67

O rs2092096 103.33 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 9.01 E-05 0.67 rs2092096 103.33 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0001251 0.69 rs2092096 103.33 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001829 0.69 rs2092096 103.33 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0001938 0.67 rs2092096 103.33 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0002277 0.69 rs2092096 103.33 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0003654 0.67 rs2092096 103.33 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0003864 0.69 rs2092101 52.54 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 22 0.0001176 1.28 rs2092101 52.54 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 22 0.0003073 1.26 rs2092101 52.54 logistic AGE:SEX Ml vs no Ml (follow-up) 22 0.0003726 1.28 rs2092101 52.54 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 22 0.0004493 1.28 rs2092101 52.54 logistic Ml vs no Ml (follow-up) 22 0.0004828 1.28 rs2092101 52.54 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 22 0.0004896 1.28 rs2096050 77.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 13 0.0001835 0.81 rs2096050 77.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 13 0.0002735 0.82 rs2113025 91.90 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0004418 1.21 rs2118310 118.41 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0004271 1.20 rs2118838 194.12 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 0.0001447 0.72

rs2118838 194.12 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0002068 0.72 rs2118838 194.12 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0003123 0.72 rs2118838 194.12 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 0.0003315 0.73 rs2118838 194.12 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 0.000343 0.72 rs2118838 194.12 logistic GE:AGE:CRCLSEX Ml vs no Ml (follow-up) 2 0.000374 0.73 rs2118838 194.12 logistic Ml vs no Ml (at entry) 2 0.0003938 0.72 rs2134634 215.42 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0003613 1.25 rs2136948 124.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0001685 1.33 rs2136948 124.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.000205 1.33 rs2136948 124.19 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.000286 1.33 rs2136948 124.19 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0003324 1.33 rs2136948 124.19 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0004639 1.33 rs2141991 137.09 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0001287 0.75 rs2141991 137.09 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 0.0001431 0.76 rs214511 33.68 logistic AGE:SEX Ml vs control (at entry) 6 0.0001693 1.38 rs214511 33.68 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.0001888 1.38 rs214511 33.68 logistic Ml vs control (at entry) 6 0.0002939 1.38

K. rs214511 33.68 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 6 0.0003014 1.38

² rs214511 33.68 logistic GE:AGE:SEX Ml vs control (at entry) 6 0.0003913 1.38 rs214742 89.29 logistic AGE:SEX Ml vs control (at entry) 11 0.0003013 0.74 rs214742 89.29 logistic Ml vs control (at entry) 11 0.0003969 0.74 rs2155647 130.20 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0003741 1.18 rs2160974 117.30 logistic AGE:SEX Ml vs control (follow-up) 12 0.0002558 1.40 rs2160974 117.30 logistic Ml vs control (follow-up) 12 0.0004327 1.40 rs2160974 117.30 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 0.0004931 1.40 rs2167769 64.12 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 18 0.0004 0.74 rs2171304 7.69 logistic Ml vs control (at entry) 10 0.0003021 0.73 rs2171965 238.40 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.000333 0.95 rs2174308 66.19 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 9 2.60E-05 1.55 rs2174308 66.19 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 8.74E-05 1.55 rs2174308 66.19 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 9 0.0001023 1.55 rs2174308 66.19 logistic AGE:SEX Ml vs control (follow-up) 9 0.0001372 1.55 rs2174308 66.19 logistic Ml vs control (follow-up) 9 0.0002612 1.55 rs2174308 66.19 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0002814 1.55 rs2189192 112.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0001485 0.74 rs2189192 112.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0003698 0.75

rs2189192 112.06 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0004225 0.74 rs2189192 112.06 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0004268 0.74 rs2189192 112.06 logistic Ml vs no Ml (follow-up) 4 0.0004529 0.74 rs2190336 62.59 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 7 0.0001171 1.46 rs2190336 62.59 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 0.0001304 1.46 rs2190336 62.59 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.000146 1.33 rs2190336 62.59 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 7 0.0001483 1.49 rs2190336 62.59 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0001899 1.46 rs2190336 62.59 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 0.0002801 1.33 rs2190336 62.59 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 0.0003067 1.49 rs2190336 62.59 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 0.0003145 1.33 rs2190336 62.59 logistic GE:AGE:SEX Ml vs control (follow-up) 7 0.0004637 1.49 rs2194390 72.65 logistic AGE:SEX Ml vs control (at entry) 2 0.0001611 1.65 rs2194390 72.65 logistic AGEiSEX Ml vs control (follow-up) 2 0.0002435 1.71 rs2194390 72.65 logistic Ml vs control (at entry) 2 0.0002939 1.65 rs2194391 72.65 logistic AGE:SEX Ml vs control (at entry) 2 0.0001364 1.66 rs2194391 72.65 logistic AGE:SEX Ml vs control (follow-up) 2 0.0002158 1.72 rs2194391 72.65 logistic Ml vs control (at entry) 2 0.0002391 1.66

K> rs2194391 72.65 logistic Ml vs control (follow-up) 2 0.0004891 1.72 rs2198552 1.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 1.44E-05 1.48 rs2198552 1.75 logistic Ml vs no Ml (follow-up) 18 3.80E-05 1.48 rs2198552 1.75 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 4.05E-05 1.48 rs2198552 1.75 logistic AGE:SEX Ml vs no Ml (follow-up) 18 4.92E-05 1.48 rs2198552 1.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 6.25E-05 1.48 rs2198552 1.75 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 6.84E-05 1.48 rs2198552 1.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 7.73E-05 1.44 rs2198552 1.75 logistic Ml vs no Ml (at entry) 18 0.0001575 1.44 rs2198552 1.75 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0001729 1.44 rs2198552 1.75 logistic AGE:SEX Ml vs no Ml (at entry) 18 0.0001976 1.44 rs2198552 1.75 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0002518 1.44 rs2198552 1.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.00026 1.44 rs2207533 43.11 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 14 0.0003308 2.27 rs2208195 44.33 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 14 0.0004303 0.80 rs2212488 99.14 logistic HBP:GE:AGE:SEX IvII vs no Ml (at entry) 11 0.00015 0.68 rs2212488 99.14 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0002697 0.71 rs2212488 99.14 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 0.0004963 0.68

rs2217889 89.22 logistic AGE:SEX Ml vs control (follow-up) 14 0.0003851 1.36 rs221871 80.70 logistic AGE:SEX Ml vs control (follow-up) 18 7.76E-05 0.59 rs221871 80.70 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 0.0001258 0.59 rs221871 80.70 logistic Ml vs control (follow-up) 18 0.0001605 0.59 rs221871 80.70 logistic GE:AGE:SEX Ml vs control (follow-up) 18 0.0002218 0.59 rs221871 80.70 logistic AGE:SEX Ml vs control (at entry) 18 0.00044 0.63 rs221873 80.70 logistic AGE:SEX Ml vs control (follow-up) 18 0.0001021 0.59 rs221873 80.70 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 0.000148 0.59 rs221873 80.70 logistic Ml vs control (follow-up) 18 0.0002218 0.59 rs221873 80.70 logistic GE:AGE:SEX Ml vs control (follow-up) 18 0.0002418 0.59 rs221873 80.70 logistic AGE:SEX Ml vs control (at entry) 18 0.0003563 0.63 rs221873 80.70 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0004643 0.63 rs221878 80.71 logistic AGE:SEX Ml vs control (follow-up) 18 9.02E-05 0.59 rs221878 80.71 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 0.0001102 0.59 rs221878 80.71 logistic GE:AGE:SEX Ml vs control (follow-up) 18 0.0002035 0.59 rs221878 80.71 logistic Ml vs control (follow-up) 18 0.0002124 0.59 rs221878 80.71 logistic AGE:SEX Ml vs control (at entry) 18 0.0004969 0.64 rs2219417 84.35 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 9.86E-05 0.47 rs2219417 84.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 0.0001183 0.47 rs2219417 84.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 11 0.0001962 0.47 rs2219417 84.35 logistic Ml vs no Ml (at entry) 11 0.0002279 0.47 rs2219417 84.35 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0003884 0.47 rs2219417 84.35 logistic HBP:GE:AGE:SEX WII vs no Ml (at entry) 11 0.0004612 0.47 rs2221112 21.86 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 5.02E-05 1.47 rs2221112 21.86 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 9.10E-05 1.52 rs2221112 21.86 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0002108 1.48 rs2224109 103.73 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 0.0002947 1.19 rs2242926 34.55 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 21 0.0003752 0.83 rs2246815 117.44 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 8 0.0001171 1.30 rs2248225 19.66 logistic Ml vs control (at entry) 21 7.41 E-05 1.40 rs2248225 19.66 logistic AGE:SEX Ml vs control (at entry) 21 8.78E-05 1.40 rs2248225 19.66 logistic GE:AGE:SEX Ml vs control (at entry) 21 0.0001668 1.40 rs2248225 19.66 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 21 0.0002192 1.40 rs2248225 19.66 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 21 0.0003053 1.40 rs2248339 19.66 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 21 0.0001713 1.36 rs2248339 19.66 logistic AGE:SEX Ml vs control (at entry) 21 0.0003014 1.36

rs2248339 19.66 logistic Ml vs control (at entry) 21 0.000304 1.36 rs2248339 19.66 logistic GE:AGE:SEX Ml vs control (at entry) 21 0.000351 1.36 rs2248564 20.68 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 13 0.0002377 1.47 rs2252538 70.13 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 3.76E-06 1.66 rs2252538 70.13 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 1 3.94E-05 1.77 rs2252538 70.13 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 7.24E-05 1.66 rs2252538 70.13 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 0.0001338 1.77 rs225549 146.86 logistic GE:AGE:SEX Ml vs control (follow-up) 12 5.47E-05 0.66 rs225549 146.86 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 6.48E-05 0.66 rs225549 146.86 logistic Ml vs control (follow-up) 12 6.78E-05 0.66 rs225549 146.86 logistic AGE:SEX Ml vs control (follow-up) 12 0.0002375 0.66 rs225549 146.86 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0004161 0.66 rs2260393 80.48 logistic AGE:SEX Ml vs control (follow-up) 6 0.0001941 0.70 rs2260393 80.48 logistic Ml vs control (follow-up) 6 0.000254 0.70 rs2260817 80.47 logistic AGE:SEX Ml vs control (follow-up) 6 0.000259 0.71 rs2260817 80.47 logistic Ml vs control (follow-up) 6 0.0003378 0.71 rs2261485 80.47 logistic AGE:SEX Ml vs control (follow-up) 6 0.0001941 0.70

^ rs2261485 80.47 logistic Ml vs control (follow-up) 6 0.000254 0.70

2 rs2267889 120.73 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 2.82E-05 0.48 rs2267889 120.73 logistic GE:AGE:SEX Ml vs control (follow-up) 7 6.92E-05 0.48 rs2267889 120.73 logistic Ml vs control (follow-up) 7 0.0003239 0.48 rs2276674 203.16 logistic Ml vs control (follow-up) 2 0.0004521 0.72 rs2276674 203.16 logistic AGE:SEX Ml vs control (follow-up) 2 0.0004694 0.72 rs2277418 59.92 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 0.0003249 0.38 rs2281014 183.47 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 4.97E-05 0.80 rs2281014 183.47 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 7.79E-05 0.83 rs2281672 144.54 logistic Ml vs control (follow-up) 10 0.0004518 0.71 rs2281672 144.54 logistic AGE:SEX Ml vs control (follow-up) 10 0.0004667 0.71 rs2283092 129.81 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 7 0.0003183 1.47 rs2287192 118.56 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 7.72E-05 0.78 rs2287192 118.56 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.0002999 0.81 rs2292343 63.91 logistic Ml vs control (at entry) 17 0.0002348 2.10 rs2292343 63.91 logistic AGE:SEX Ml vs control (at entry) 17 0.0002653 2.10 rs2294208 30.09 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 22 0.0003521 0.75 rs2294208 30.09 logistic GE:AGE:SEX Ml vs control (at entry) 22 0.0003784 0.75 rs2297330 49.51 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 4.29E-05 1.34

rs2297330 49.51 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 10 0.0004162 1.34 rs2298517 19.66 logistic AGE:SEX Ml vs control (at entry) 21 8.98E-05 1.40 rs2298517 19.66 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 21 0.0001457 1.40 rs2298517 19.66 logistic Ml vs control (at entry) 21 0.0001858 1.40 rs2298517 19.66 logistic AGE:SEX Ml vs no Ml (follow-up) 21 0.0002659 1.28 rs2298517 19.66 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 21 0.0003212 1.28 rs2298517 19.66 logistic GE:AGE:SEX Ml vs control (at entry) 21 0.0003801 1.40 rs2298517 19.66 logistic AGE:SEX Ml vs no Ml (at entry) 21 0.0004083 1.28 rs2298517 19.66 logistic Ml vs no Ml (follow-up) 21 0.000413 1.28 rs2298517 19.66 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 21 0.0004811 1.28 rs2299961 162.78 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 0.0001203 0.79 rs2299961 162.78 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 0.0004857 0.79 rs230157 57.98 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 2.19E-05 1.39 rs230157 57.98 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 4.89E-05 1.37 rs230157 57.98 logistic GE:AGE:SEX Ml vs no Ml (at entry) 20 5.71 E-05 1.39 rs230157 57.98 logistic Ml vs no Ml (at entry) 20 9.54E-05 1.39 rs230157 57.98 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 20 0.0001132 1.37 rs230157 57.98 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 20 0.0001136 1.39 rs230157 57.98 logistic Ml vs no Ml (follow-up) 20 0.0001404 1.37 rs230157 57.98 logistic AGE:SEX Ml vs no Ml (at entry) 20 0.0001978 1.39 rs230157 57.98 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 20 0.0002172 1.37 rs230157 57.98 logistic GE:AGE:SEX Ml vs control (at entry) 20 0.0002787 1.43 rs230157 57.98 logistic AGE:SEX Ml vs no Ml (follow-up) 20 0.0003305 1.37 rs230157 57.98 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 20 0.000368 1.39 rs230157 57.98 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 20 0.0004629 1.43 rs2304496 61.97 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 17 0.0003532 0.71 rs2310047 195.50 logistic Ml vs no Ml (follow-up) 4 0.0002617 1.29 rs2310047 195.50 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0003506 1.29 rs2310047 195.50 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0004022 1.29 rs2310047 195.50 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0004846 1.29 rs2312150 99.28 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0001356 0.73 rs2312150 99.28 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0001474 0.73 rs2312150 99.28 logistic AGEiSEX Ml vs control (at entry) 1 0.0002731 0.73 rs2312150 99.28 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.0003078 0.73 rs2316310 124.56 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 7.25E-05 0.71 rs2316310 124.56 logistic GE:AGE:SEX Ml vs control (at entry) 8 7.40E-05 0.71

rs2316310 124.56 logistic AGE:SEX Ml vs control (at entry) 8 0.0001065 0.71 rs2316310 124.56 logistic Ml vs control (at entry) 8 0.000126 0.71 rs2316310 124.56 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0003997 0.78 rs2316310 124.56 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0004156 0.78 rs2316310 124.56 logistic Ml vs no Ml (at entry) 8 0.000447 0.78 rs2316310 124.56 logistic Ml vs no Ml (follow-up) 8 0.0004983 0.78 rs2318149 73.48 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.000263 1.32 rs2319227 77.45 logistic AGE:SEX Ml vs control (at entry) 4 0.0004001 1.63 rs2319227 77.45 logistic AGE:SEX Ml vs control (follow-up) 4 0.0004762 1.73 rs2319231 77.47 logistic AGEiSEX Ml vs control (at entry) 4 0.0004811 1.62 rs2327351 132.87 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 6 3.20E-05 0.75 rs2327351 132.87 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.0004706 0.82 rs2328391 35.11 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 6 0.0004933 1.25 rs2342435 9.85 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 16 0.0003868 1.14 rs2345589 1.74 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 1.45E-05 1.47 rs2345589 1.74 logistic Ml vs no Ml (follow-up) 18 4.51 E-05 1.47 rs2345589 1.74 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 4.75E-05 1.47 rs2345589 1.74 logistic AGE:SEX Ml vs no Ml (follow-up) 18 5.63E-05 1.47

Os rs2345589 1.74 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 7.34E-05 1.47 rs2345589 1.74 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 8.04E-05 1.47 rs2345589 1.74 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0001031 1.42 rs2345589 1.74 logistic Ml vs no Ml (at entry) 18 0.0002362 1.42 rs2345589 1.74 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.000259 1.42 rs2345589 1.74 logistic AGE:SEX Ml vs no Ml (at entry) 18 0.0002874 1.42 rs2345589 1.74 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0003787 1.42 rs2345589 1.74 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0003868 1.42 rs2349251 49.52 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 22 0.0004313 1.38 rs2349251 49.52 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 22 0.0004988 1.38 rs2351044 21.04 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0002309 1.21 rs2358766 142.46 logistic AGE:SEX Ml vs control (follow-up) 3 0.000301 0.74 rs2369522 115.66 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 14 0.0001338 1.40 rs2369522 115.66 logistic GE:AGE:SEX Ml vs control (follow-up) 14 0.0002703 1.40 rs2369522 115.66 logistic AGEiSEX Ml vs control (follow-up) 14 0.0003514 1.40 rs2369522 115.66 logistic Ml vs control (follow-up) 14 0.0004043 1.40 rs2370413 3.30 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 0.0001243 1.12 rs2370919 51.40 logistic Ml vs no Ml (at entry) 3 2.92E-05 0.42

rs2370919 51.40 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 4.40E-05 0.42 rs2370919 51.40 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 4.45E-05 0.42 rs2370919 51.40 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 6.81 E-05 0.42 rs2370919 51.40 logistic AGE:SEX Ml vs no Ml (at entry) 3 7.09E-05 0.42 rs2370919 51.40 logistic Ml vs control (at entry) 3 0.000303 0.42 rs2370919 51.40 logistic GE:AGE:SEX Ml vs control (at entry) 3 0.0003267 0.42 rs2370919 51.40 logistic AGE:SEX Ml vs control (at entry) 3 0.0004759 0.42 rs2370919 51.40 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 3 0.0004911 0.42 rs2380426 29.02 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 2 0.0003235 1.16 rs2389316 78.26 logistic AGE:SEX Ml vs control (at entry) 13 0.0004571 1.45 rs2397989 11.58 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 0.0002407 1.20 rs2399308 125.55 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0001982 1.55 rs2399308 125.55 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 0.0002148 1.55 rs2399308 125.55 logistic AGE:SEX Ml vs no Ml (follow-up) 3 0.0003294 1.55 rs2399308 125.55 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0004768 1.51 rs2399308 125.55 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 0.0004784 1.55 rs2400000 92.70 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 11 0.0002 1.23 rs2403054 92.53 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.000353 0.70 rs2403123 93.09 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0002369 0.78 rs2408467 60.06 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 2.80E-05 0.36 rs2408467 60.06 logistic Ml vs no Ml (at entry) 12 3.53E-05 0.36 rs2408467 60.06 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 3.58E-05 0.36 rs2408467 60.06 logistic GE:AGE:CRCL:SEX Ml vs no Mi (at entry) 12 4.79E-05 0.36 rs2408467 60.06 logistic AGE:SEX Ml vs no Ml (at entry) 12 5.89E-05 0.36 rs2408467 60.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0001379 0.36 rs241218 9.27 logistic AGE:SEX Ml vs no Ml (follow-up) 1 3.54E-05 0.71 rs241218 9.27 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 8.68E-05 0.71 rs241218 9.27 logistic Ml vs no Ml (follow-up) 1 9.16E-05 0.71 rs241218 9.27 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0001266 0.71 rs241218 9.27 logistic AGE:SEX Ml vs no Ml (at entry) 1 0.0001584 0.72 rs241218 9.27 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.0001901 0.71 rs241218 9.27 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0002356 0.71 rs241218 9.27 logistic Ml vs no Ml (at entry) 1 0.0003256 0.72 rs241218 9.27 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 0.0003951 0.72 rs2412586 63.47 logistic GE:AGE:SEX Ml vs control (at entry) 4 7.65E-05 1.38 rs2412586 63.47 logistic AGE:SEX Ml vs control (at entry) 4 0.0001234 1.38

rs2412586 63.47 logistic GE:AGE:CRCLSEX Ml vs control (at entry) 4 0.0001718 1.38 rs2412586 63.47 logistic Ml vs control (at entry) 4 0.000198 1.38 rs2419533 131.20 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 4 0.0002516 1.36 rs2419620 131.19 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 5.18E-05 1.31 rs2419620 131.19 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 7.62E-05 1.31 rs2419620 131.19 logistic Ml vs no Ml (follow-up) 10 7.94E-05 1.31 rs2419620 131.19 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.0001006 1.31 rs2419620 131.19 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0001066 1.31 rs2419620 131.19 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 0.0002153 1.32 rs2419620 131.19 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 10 0.0002497 1.38 rs2419620 131.19 logistic GE:AGE:SEX Ml vs control (follow-up) 10 0.0003878 1.38 rs2419620 131.19 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0004357 1.31 rs2419620 131.19 logistic GE:AGE:SEX Ml vs control (at entry) 10 0.000478 1.32 rs2425520 58.28 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 20 0.0001434 0.72 rs2425520 58.28 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 0.0002302 0.78 rs2425520 58.28 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 0.000284 0.79 rs2430988 53.21 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 17 0.0003165 1.25 rs2435242 213.26 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 0.0003968 1.25

OO rs243839 73.56 logistic GE:AGE:SEX Ml vs control (at entry) 16 0.0001721 1.57 rs243839 73.56 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 16 0.0001839 1.57 rs243839 73.56 logistic AGE:SEX Ml vs control (at entry) 16 0.0002078 1.57 rs243839 73.56 logistic Ml vs control (at entry) 16 0.0002271 1.57 rs244097 61.14 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 20 0.0001487 1.42 rs244097 61.14 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 20 0.0003795 1.34 rs244098 61.14 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 20 0.0004535 1.41 rs244104 61.13 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 20 2.76E-05 1.45 rs244104 61.13 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 20 9.98E-05 1.35 rs2449818 4.29 logistic AGE:SEX Ml vs control (follow-up) 8 0.0002553 0.73 rs2452461 80.49 logistic AGE:SEX Ml vs control (follow-up) 6 0.0002269 0.70 rs2452461 80.49 logistic Ml vs control (follow-up) 6 0.0002931 0.70 rs2452463 80.49 logistic AGE:SEX Ml vs control (follow-up) 6 0.0001009 0.69 rs2452463 80.49 logistic Ml vs control (follow-up) 6 0.0001281 0.69 rs2452463 80.49 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 6 0.0003713 0.69 rs2452464 80.49 logistic AGE:SEX Ml vs control (follow-up) 6 0.0001722 0.70 rs2452464 80.49 logistic Ml vs control (follow-up) 6 0.0002282 0.70 rs2466848 53.35 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 17 0.000296 1.26

rs2479373 148.85 logistic AGE:SEX Ml vs no Ml (follow-up) 1 0.0001793 0.41 rs2479373 148.85 logistic Ml vs no Ml (follow-up) 1 0.0001832 0.41 rs2479373 148.85 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.0002494 0.41 rs2479373 148.85 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0003602 0.41 rs2482496 124.86 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 3.14E-05 1.24 rs2482496 124.86 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.000101 1.22 rs2492803 80.48 logistic AGE:SEX Ml vs control (follow-up) 6 0.0002163 0.70 rs2492803 80.48 logistic Ml vs control (follow-up) 6 0.000253 0.70 rs2499796 103.32 logistic Ml vs no Ml (at entry) 6 2.80E-05 0.66 rs2499796 103.32 logistic AGE:SEX Ml vs no Ml (at entry) 6 3.88E-05 0.66 rs2499796 103.32 logistic Ml vs no Ml (follow-up) 6 4.57E-05 0.68 rs2499796 103.32 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 6.61 E-05 0.66 rs2499796 103.32 logistic AGEiSEX Ml vs no Ml (follow-up) 6 6.69E-05 0.68 rs2499796 103.32 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 7.93E-05 0.66 rs2499796 103.32 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001037 0.68 rs2499796 103.32 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0001251 0.68 rs2499796 103.32 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0002647 0.66 rs2499796 103.32 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.000331 0.68 rs2499796 103.32 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0004201 0.68 rs2499797 103.32 logistic Ml vs no Ml (at entry) 6 2.81 E-05 0.66 rs2499797 103.32 logistic AGE:SEX Ml vs no Ml (at entry) 6 3.82E-05 0.66 rs2499797 103.32 logistic Ml vs no Ml (follow-up) 6 4.11 E-05 0.67 rs2499797 103.32 logistic AGE:SEX Ml vs no Ml (follow-up) 6 5.89E-05 0.67 rs2499797 103.32 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 6.45E-05 0.66 rs2499797 103.32 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 7.82E-05 0.66 rs2499797 103.32 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 9.11 E-05 0.67 rs2499797 103.32 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0001113 0.67 rs2499797 103.32 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0002715 0.66 rs2499797 103.32 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0002921 0.67 rs2499797 103.32 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0003865 0.67 rs250578 43.32 logistic Ml vs control (follow-up) 16 0.0002266 1.56 rs250578 43.32 logistic AGE:SEX Ml vs control (follow-up) 16 0.0003418 1.56 rs250583 43.27 logistic Ml vs control (follow-up) 16 0.0002529 1.56 rs250583 43.27 logistic AGE:SEX Ml vs control (follow-up) 16 0.0003522 1.56 rs2513922 116.77 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0003737 1.27 rs2513922 116.77 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0003901 1.27

rs2513922 116.77 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 0.0004291 1.27 rs2513922 116.77 logistic AGE:SEX Ml vs no Ml (at entry) 8 0.0004606 1.27 rs2513922 116.77 logistic Ml vs no Ml (at entry) 8 0.0004617 1.27 rs251684 73.12 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 19 0.0001306 0.71 rs251684 73.12 logistic GE:AGE:SEX Ml vs control (follow-up) 19 0.0001995 0.71 rs251684 73.12 logistic AGE:SEX Ml vs control (follow-up) 19 0.0003284 0.71 rs2527031 96.07 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 7 0.0003754 0.88 rs2528632 162.65 logistic Ml vs no Ml (follow-up) 2 0.0004499 1.27 rs2528632 162.65 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0004589 1.27 rs254287 136.05 logistic Ml vs control (at entry) 5 0.0001797 1.83 rs254287 136.05 logistic AGE:SEX Ml vs control (at entry) 5 0.000257 1.83 rs2544995 165.12 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0001542 0.80 rs2544995 165.12 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.0002362 0.80 rs2545618 110.13 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0002866 0.85 rs2554622 4.19 logistic AGEiSEX Ml vs no Ml (at entry) 8 0.0002598 0.77 rs2554622 4.19 logistic Ml vs no Ml (at entry) 8 0.0003224 0.77 rs2554622 4.19 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 0.0003354 0.77 rs2554622 4.19 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0004325 0.77

O rs256514 98.11 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0004317 0.79 rs2565142 64.44 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0004921 1.29 rs2568491 74.11 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 15 0.0002179 0.10 rs2568491 74.11 logistic AGE:SEX Ml vs control (follow-up) 15 0.000228 0.10 rs2568491 74.11 logistic GE:AGE:SEX Ml vs control (follow-up) 15 0.0002327 0.10 rs2568491 74.11 logistic Ml vs control (follow-up) 15 0.0003816 0.10 rs2568491 74.11 logistic AGE:SEX Ml vs control (at entry) 15 0.0004186 0.07 rs2573625 114.57 logistic Ml vs control (follow-up) 15 7.86E-05 0.68 rs2573625 114.57 logistic AGE:SEX Ml vs control (follow-up) 15 0.0002826 0.68 rs2577592 119.50 logistic Ml vs control (follow-up) 2 0.0002294 0.61 rs2577592 119.50 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 2 0.0003217 0.61 rs2577592 119.50 logistic AGE:SEX Ml vs control (follow-up) 2 0.0003259 0.61 rs2577592 119.50 logistic GE:AGE:SEX Ml vs control (follow-up) 2 0.0003519 0.61 rs2581345 114.57 logistic Ml vs control (follow-up) 15 0.000318 0.70 rs2585512 60.85 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 0.000201 0.53 rs2585512 60.85 logistic Ml vs no Ml (at entry) 13 0.0003766 0.53 rs2585512 60.85 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 13 0.0004174 0.53 rs2585669 61.39 logistic Ml vs control (at entry) 9 0.0002372 0.67

rs2585669 61.39 logistic AGE:SEX Ml vs control (at entry) 9 0.0002429 0.67 rs2586949 76.92 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 2 0.0002992 1.48 rs2590260 103.50 logistic AGE:SEX Ml vs control (at entry) 17 0.000457 0.75 rs2590260 103.50 logistic AGE:SEX Ml vs no Ml (follow-up) 17 0.0004616 0.79 rs2596929 29.94 logistic AGE:SEX Ml vs control (at entry) 3 0.000283 1.41 rs2597519 37.84 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 0.0004835 1.32 rs2600998 203.08 logistic GE:AGE:SEX Ml vs control (follow-up) 3 0.0002996 0.75 rs2600998 203.08 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 3 0.0003152 0.75 rs2602707 17.67 logistic GE:AGE:SEX Ml vs no Ml (at entry) 19 4.42E-07 0.10 rs2602707 17.67 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 19 5.50E-07 0.10 rs2602707 17.67 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 19 5.81 E-07 0.10 rs2602707 17.67 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 19 6.36E-07 0.10 rs2602707 17.67 logistic Ml vs no Ml (at entry) 19 6.55E-07 0.10 rs2602707 17.67 logistic AGE:SEX Ml vs no Ml (at entry) 19 1.17E-06 0.10 rs2602707 17.67 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 19 1.21 E-06 0.20 rs2602707 17.67 logistic Ml vs no Ml (follow-up) 19 1.36E-06 0.20 rs2602707 17.67 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 19 1.64E-06 0.20

K. rs2602707 17.67 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 19 2.01 E-06 0.20

^ rs2602707 17.67 logistic AGE:SEX Ml vs no Ml (follow-up) 19 3.52E-06 0.20 rs2602707 17.67 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 19 3.61 E-06 0.20 rs2602707 17.67 logistic GE:AGE:SEX Ml vs control (at entry) 19 1.07E-05 0.13 rs2602707 17.67 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 19 1.60E-05 0.13 rs2602707 17.67 logistic Ml vs control (at entry) 19 2.08E-05 0.13 rs2602707 17.67 logistic AGEiSEX Ml vs control (at entry) 19 2.56E-05 0.13 rs2602707 17.67 logistic GE:AGE:SEX Ml vs control (follow-up) 19 0.0001116 0.23 rs2602707 17.67 logistic Ml vs control (follow-up) 19 0.000131 0.23 rs2602707 17.67 logistic AGE:SEX Ml vs control (follow-up) ^• 19 0.0001728 0.23 rs2602707 17.67 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 19 0.0001795 0.13 rs2602707 17.67 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 19 0.000184 0.23 rs2618162 37.09 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 15 0.0002772 1.30 rs2623069 107.55 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0004395 1.32 rs2631709 37.25 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 15 0.0003547 1.43 rs2631709 37.25 logistic GE:AGE:SEX Ml vs no Ml (at entry) 15 0.0004569 1.43 rs2632188 99.98 logistic Ml vs no Ml (follow-up) 14 0.000302 0.78 rs2632188 99.98 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 14 0.0003367 0.78 rs2632188 99.98 logistic AGE:SEX Ml vs no Ml (follow-up) 14 0.0004698 0.78

rs2638504 67.86 logistic AGE:SEX Ml vs no Ml (at entry) 12 0.0001473 1.31 rs2638504 67.86 logistic AGE:SEX Ml vs no Ml (follow-up) 12 0.0001927 1.30 rs2638504 67.86 logistic Ml vs no Ml (at entry) 12 0.0002152 1.31 rs2638504 67.86 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0002577 1.31 rs2638504 67.86 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.00026 1.30 rs2638504 67.86 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.0002907 1.30 rs2638504 67.86 logistic Ml vs no Ml (follow-up) 12 0.0003003 1.30 rs2638504 67.86 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0003184 1.31 rs2638504 67.86 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 0.0003259 1.31 rs2638504 67.86 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0003633 1.30 rs2640485 143.75 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 1 9.61 E-05 1.28 rs2640485 143.75 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.0003275 1.19 rs2645778 252.58 logistic Ml vs no Ml (follow-up) 2 0.0002768 1.31 rs2645778 252.58 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0003299 1.31 rs2645778 252.58 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0003321 1.31 rs2645778 252.58 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0004711 1.31 rs2647442 239.48 logistic GE:AGE:SEX Ml vs control (at entry) 1 8.39E-05 1.37 rs2647442 239.48 logistic AGE:SEX Ml vs control (at entry) 1 0.0001648 1.37

K) rs2647442 239.48 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0001815 1.37 rs2647442 239.48 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 0.0002917 1.37 rs2647442 239.48 logistic Ml vs control (at entry) 1 0.0003673 1.37 rs2652148 4.88 logistic Ml vs no Ml (follow-up) 5 0.0003093 0.73 rs2652148 4.88 logistic Ml vs control (follow-up) 5 0.0003133 0.65 rs2652148 4.88 logistic AGEiSEX Ml vs no Ml (follow-up) 5 0.0004694 0.73 rs2664124 37.24 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 15 0.0003547 1.43 rs2664124 37.24 logistic GE:AGE:SEX Ml vs no Ml (at entry) 15 0.0004569 1.43 rs2667406 130.99 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0003377 1.32 rs2667406 130.99 logistic Ml vs no Ml (follow-up) 4 0.0003403 1.32 rs2667406 130.99 logistic AGEiSEX Ml vs control (at entry) 4 0.0003954 1.41 rs2667406 130.99 logistic GEiAGEiACRiSEX Ml vs no Ml (follow-up) 4 0.000407 1.32 rs2667406 130.99 logistic Ml vs control (at entry) 4 0.0004208 1.41 rs2667406 130.99 logistic GEIAGEISEX Ml vs no Ml (follow-up) 4 0.0004258 1.32 rs2667406 130.99 logistic GEiAGEiCRCLiSEX Ml vs no Ml (follow-up) 4 0.0004746 1.32 rs2667406 130.99 logistic HBPIGEIAGEISEX Ml vs no Ml (follow-up) 4 0.0004886 1.32 rs2669438 117.44 logistic GEIAGEIACRISEX Ml vs control (at entry) 8 0.0002174 1.27 rs2679749 116.78 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 8 0.0004093 1.27

rs2679749 116.78 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 0.0004774 1.27 rs2679752 116.79 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.000457 1.27 rs2679752 116.79 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.000478 1.27 rs2679754 116.79 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0003642 1.26 rs2682295 67.86 logistic AGE:SEX Ml vs no Ml (follow-up) 12 0.000336 1.28 rs2682295 67.86 logistic Ml vs no Ml (follow-up) 12 0.0004413 1.28 rs2682295 67.86 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.0004753 1.28 rs2682295 67.86 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.0004811 1.28 rs2682295 67.86 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0004863 1.28 rs2683690 85.95 logistic Ml vs control (follow-up) 2 0.0002156 1.46 rs2683690 85.95 logistic Ml vs control (at entry) 2 0.0002601 1.41 rs2683690 85.95 logistic AGE:SEX Ml vs control (follow-up) 2 0.0002854 1.46 rs2683690 85.95 logistic AGE:SEX Ml vs control (at entry) 2 0.000376 1.41 rs268387 30.81 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0004459 0.82 rs268599 88.70 logistic GE:AGE:SEX Ml vs control (at entry) 8 0.0001452 1.46 rs268599 88.70 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 0.0001721 1.46 rs268599 88.70 logistic Ml vs control (at entry) 8 0.000287 1.46 rs268599 88.70 logistic AGEiSEX Ml vs control (at entry) 8 0.0003978 1.46 rs2699749 124.48 logistic GE:AGE:SEX Ml vs no Ml (at entry) 7 3.70E-06 0.16 rs2699749 124.48 logistic Ml vs no Ml (at entry) 7 3.91 E-06 0.16 rs2699749 124.48 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 7 4.86E-06 0.16 rs2699749 124.48 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 7 4.91 E-06 0.16 rs2699749 124.48 logistic Ml vs no Ml (follow-up) 7 6.51 E-06 0.21 rs2699749 124.48 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 7.82E-06 0.21 rs2699749 124.48 logistic AGE:SEX Ml vs no Ml (at entry) 7 8.06E-06 0.16 rs2699749 124.48 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 7 9.49E-06 0.16 rs2699749 124.48 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 1.08E-05 0.21 rs2699749 124.48 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 1.17E-05 0.21 rs2699749 124.48 logistic AGEiSEX Ml vs no Ml (follow-up) 7 1.74E-05 0.21 rs2699749 124.48 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 7 3.08E-05 0.21 rs2699749 124.48 logistic GE:AGE:SEX Ml vs control (at entry) 7 9.62E-05 0.18 rs2699749 124.48 logistic GE:AGE:SEX Ml vs control (follow-up) 7 0.0001697 0.22 rs2699749 124.48 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 0.0001736 0.18 rs2699749 124.48 logistic Ml vs control (at entry) 7 0.0001994 0.18 rs2699749 124.48 logistic Ml vs control (follow-up) 7 0.000238 0.22 rs2699749 124.48 logistic AGE:SEX Ml vs control (at entry) 7 0.0002477 0.18

rs2699749 124.48 logistic AGE:SEX Ml vs control (follow-up) 7 0.0002995 0.22 rs2699749 124.48 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 0.0003109 0.22 rs2706364 135.71 logistic Ml vs no Ml (at entry) 5 3.01 E-06 0.24 rs2706364 135.71 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 3.53E-06 0.24 rs2706364 135.71 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 4.82E-06 0.24 rs2706364 135.71 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 5.08E-06 0.24 rs2706364 135.71 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 5.14E-06 0.24 rs2706364 135.71 logistic AGE:SEX Ml vs no Ml (at entry) 5 8.61 E-06 0.24 rs2706364 135.71 logistic Ml vs no Ml (follow-up) 5 2.74E-05 0.33 rs2706364 135.71 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 4.47E-05 0.33 rs2706364 135.71 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 6.44E-05 0.33 rs2706364 135.71 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 6.88E-05 0.33 rs2706364 135.71 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 9.52E-05 0.33 rs2706364 135.71 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.0001039 0.33 rs2714050 122.49 logistic Ml vs no Ml (at entry) 11 0.0002287 1.33 rs2714050 122.49 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0002357 1.33 rs2715654 59.77 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0001004 0.58

^ rs2715654 59.77 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0001188 0.58

≤ rs2715654 59.77 logistic Ml vs no Ml (at entry) 4 0.0001309 0.58 rs2715654 59.77 logistic AGEiSEX Ml vs no Ml (at entry) 4 0.0001614 0.58 rs2715654 59.77 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0002385 0.58 rs2715654 59.77 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0003885 0.58 rs2726164 112.22 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.000389 0.75 rs2730306 19.97 logistic GE:AGE:SEX Ml vs control (follow-up) 3 0.0003743 2.16 rs2732248 114.92 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0004286 1.27 rs2732248 114.92 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0004866 1.27 rs2738078 9.66 logistic GE:AGE:SEX Ml vs control (follow-up) 8 5.35E-05 0.63 rs2738078 9.66 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 8 8.52E-05 0.63 rs2738078 9.66 logistic Ml vs control (follow-up) 8 0.0001382 0.63 rs2738078 9.66 logistic AGEiSEX Ml vs control (follow-up) 8 0.0002881 0.63 rs2738079 9.66 logistic GEIAGEISEX Ml vs control (follow-up) 8 0.0001604 0.65 rs2738079 9.66 logistic GEiAGEiCRCLSEX Ml vs control (follow-up) 8 0.0002663 0.65 rs2738079 9.66 logistic Ml vs control (follow-up) 8 0.0004167 0.65 rs2794515 165.59 logistic HBPIGEIAGEISEX Ml vs control (at entry) 1 0.0003906 1.18 rs2806735 45.45 logistic HBPIGEIAGEISEX Ml vs control (follow-up) 13 6.77E-05 1.41 rs280983 10.30 logistic GEIAGEISEX Ml vs control (at entry) 18 0.0001968 1.34

rs280983 10.30 logistic GE:AGE:SEX WII vs no Ml (at entry) 18 0.0002349 1.25 rs280983 10.30 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0002914 1.25 rs280983 10.30 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0003561 1.34 rs280983 10.30 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0004689 1.25 rs280984 10.30 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0003698 1.32 rs2810740 61.39 logistic Ml vs control (at entry) 9 0.0001614 0.66 rs2810740 61.39 logistic AGE:SEX Ml vs control (at entry) 9 0.0001751 0.66 rs2814689 80.49 logistic AGE:SEX Ml vs control (follow-up) 6 0.0002054 0.70 rs2814689 80.49 logistic Ml vs control (follow-up) 6 0.0002482 0.70 rs2815143 13.62 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 6 0.0003475 0.70 rs2815143 13.62 logistic GE:AGE:SEX Ml vs control (follow-up) 6 0.0003884 0.70 rs2815167 13.58 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 6 0.0004841 0.71 rs2815385 99.39 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0004263 1.23 rs2815792 118.45 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0004157 1.35 rs2829267 19.65 logistic Ml vs control (at entry) 21 0.0003834 1.35 rs2829267 19.65 logistic AGE:SEX Ml vs control (at entry) 21 0.000484 1.35 rs2829290 19.66 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 21 0.0003629 1.33 rs2829819 20.18 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 21 5.05E-06 0.17 rs2829819 20.18 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 21 6.28E-06 0.08 rs2829819 20.18 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 21 6.44E-06 0.17 rs2829819 20.18 logistic GE:AGE:SEX Ml vs no Ml (at entry) 21 6.56E-06 0.08 rs2829819 20.18 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 21 6.78E-06 0.17 rs2829819 20.18 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 21 7.35E-06 0.08 rs2829819 20.18 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 21 7.65E-06 0.08 rs2829819 20.18 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 21 8.61 E-06 0.17 rs2829819 20.18 logistic Ml vs no Ml (follow-up) 21 1.02E-05 0.17 rs2829819 20.18 logistic Ml vs no Ml (at entry) 21 1.30E-05 0.08 rs2829819 20.18 logistic AGE:SEX Ml vs no Ml (follow-up) 21 1.66E-05 0.17 rs2829819 20.18 logistic AGE:SEX Ml vs no Ml (at entry) 21 1.71 E-05 0.08 rs2829819 20.18 logistic GE:AGE:SEX Ml vs control (follow-up) 21 6.47E-05 0.19 rs2829819 20.18 logistic GE:AGE:SEX Ml vs control (at entry) 21 0.0001 0.09 rs2829819 20.18 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 21 0.0001059 0.19 rs2829819 20.18 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 21 0.0001303 0.09 rs2829819 20.18 logistic AGE:SEX Ml vs control (follow-up) 21 0.0001695 0.19 rs2829819 20.18 logistic AGEiSEX Ml vs control (at entry) 21 0.0001743 0.09 rs2829819 20.18 logistic Ml vs control (at entry) 21 0.000175 0.09

rs2829819 20.18 logistic Ml vs control (follow-up) 21 0.0001802 0.19 rs2838873 54.94 logistic Ml vs control (follow-up) 21 0.0001377 0.67 rs2838873 54.94 logistic GE:AGE:SEX Ml vs control (follow-up) 21 0.0002635 0.67 rs2838873 54.94 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 21 0.0003023 0.67 rs2838873 54.94 logistic AGE:SEX Ml vs control (follow-up) 21 0.0003163 0.67 rs2839580 49.84 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 21 9.44E-05 0.77 rs2839580 49.84 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 21 0.0001265 0.77 rs2839580 49.84 logistic AGE:SEX Ml vs no Ml (follow-up) 21 0.0001313 0.77 rs2839580 49.84 logistic Ml vs no Ml (follow-up) 21 0.0001519 0.77 rs2839580 49.84 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 21 0.0001777 0.77 rs28490018 114.69 logistic Ml vs control (follow-up) 14 2.25E-05 0.58 rs28490018 114.69 logistic AGE:SEX Ml vs control (follow-up) 14 4.28E-05 0.58 rs28490018 114.69 logistic GE:AGE:SEX Ml vs control (follow-up) 14 0.0001299 0.58 rs28490018 114.69 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 14 0.0001774 0.58 rs2849395 41.57 logistic AGE:SEX Ml vs control (follow-up) 18 0.0003811 0.72 rs2849463 80.69 logistic AGE:SEX Ml vs control (follow-up) 18 0.0004329 0.63 rs2850935 119.47 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 18 0.0001685 1.31 rs2851911 41.57 logistic AGE:SEX Ml vs control (follow-up) 18 0.0003811 0.72 rs2851912 41.57 logistic AGE:SEX Ml vs control (follow-up) 18 0.0003811 0.72 rs2863200 99.40 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0001912 1.27 rs2863200 99.40 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0002575 1.25 rs2863200 99.40 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.000296 1.26 rs2894058 86.62 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0003945 1.10 rs2894324 96.59 logistic Ml vs control (at entry) 10 0.0003906 0.70 rs2912020 8.49 logistic AGE:SEX Ml vs control (at entry) 8 0.0002913 0.70 rs2912020 8.49 logistic Ml vs control (at entry) 8 0.0002961 0.70 rs291550 127.86 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 0.0003759 0.70 rs2926095 66.39 logistic Ml vs control (at entry) 8 0.000466 0.59 rs2926110 66.36 logistic Ml vs control (at entry) 8 0.0001124 0.54 rs2926110 66.36 logistic AGE:SEX Ml vs control (at entry) 8 0.0001942 0.54 rs2926110 66.36 logistic Ml vs control (follow-up) 8 0.0004041 0.56 rs2935260 62.49 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 5 0.0004053 1.56 rs2936534 8.49 logistic AGE:SEX Ml vs control (at entry) 8 0.0003285 0.70 rs2936534 8.49 logistic Ml vs control (at entry) 8 0.0003522 0.70 rs2936535 8.48 logistic Ml vs control (at entry) 8 0.0003879 0.70 rs2936535 8.48 logistic AGE:SEX Ml vs control (at entry) 8 0.0003902 0.70

rs2942884 112.37 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0003347 1.28 rs2942884 112.37 logistic Ml vs no Ml (at entry) 2 0.0003421 1.28 rs2956830 66.37 logistic Ml vs control (at entry) 8 0.0002091 0.57 rs2956830 66.37 logistic AGE:SEX Ml vs control (at entry) 8 0.0003296 0.57 rs2960744 151.08 logistic AGEiSEX Ml vs control (at entry) 7 4.18E-05 0.70 rs2960744 151.08 logistic Ml vs control (at entry) 7 5.59E-05 0.70 rs2960744 151.08 logistic AGE:SEX Ml vs control (follow-up) 7 8.48E-05 0.70 rs2960744 151.08 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 0.0001001 0.70 rs2960744 151.08 logistic Ml vs control (follow-up) 7 0.0001415 0.70 rs2960744 151.08 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0001723 0.70 rs2960744 151.08 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 0.0001895 0.70 rs2960744 151.08 logistic GE:AGE:SEX Ml vs control (follow-up) 7 0.0003237 0.70 rs30012 43.31 logistic Ml vs control (follow-up) 16 0.0003712 1.53 rs301163 123.87 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 16 5.38E-05 1.38 rs301163 123.87 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 16 0.0001654 1.28 rs301163 123.87 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 16 0.0004138 1.30 rs301163 123.87 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 16 0.0004143 1.38 κ> rs301163 123.87 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 16 0.0004479 1.30

^ rs301164 123.87 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 16 0.0002638 1.35 rs301164 123.87 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 16 0.0004576 1.25 rs301583 89.30 logistic AGE:SEX Ml vs control (at entry) 11 0.0002283 0.73 rs301583 89.30 logistic Ml vs control (at entry) 11 0.0002908 0.73 rs3019442 166.37 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 6 0.0003829 1.38 rs3019442 166.37 logistic GE:AGE:SEX Ml vs control (follow-up) 6 0.0003934 1.38 rs303765 65.74 logistic AGE:SEX Ml vs control (at entry) 12 0.0002412 0.74 rs303765 65.74 logistic Ml vs control (at entry) 12 0.0003865 0.74 rs30751 139.42 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 4.47E-05 2.44 rs30751 139.42 logistic Ml vs no Ml (at entry) 5 4.67E-05 2.44 rs30751 139.42 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 5.39E-05 2.44 rs30751 139.42 logistic AGE:SEX Ml vs no Ml (at entry) 5 6.38E-05 2.44 rs30751 139.42 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 7.11 E-05 2.44 rs30751 139.42 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 8.62E-05 2.44 rs30751 139.42 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.0002478 2.22 rs30751 139.42 logistic Ml vs no Ml (follow-up) 5 0.0002565 2.22 rs30751 139.42 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0003359 2.22 rs30751 139.42 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.0003579 2.22

rs30751 139.42 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0004423 2.22 rs3091251 62.45 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 8.37E-05 1.56 rs3091251 62.45 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 0.00027 1.56 rs3091251 62.45 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 5 0.0002753 1.58 rs3091251 62.45 logistic Ml vs control (at entry) 0.0003145 1.56 rs3091251 62.45 logistic AGE:SEX Ml vs control (at entry) 5 0.0003634 1.56 rs3091251 62.45 logistic GE:AGE:SEX Ml vs control (at entry) 0.0003654 1.56 rs3091252 62.44 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 0.0001241 1.55 rs3091252 62.44 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 0.000328 1.55 rs3091252 62.44 logistic Ml vs control (at entry) 0.0003796 1.55 rs3091252 62.44 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 5 0.0003846 1.57 rs3091252 62.44 logistic AGE:SEX Ml vs control (at entry) 5 0.0004281 1.55 rs3091252 62.44 logistic GE:AGE:SEX Ml vs control (at entry) 5 0.0004418 1.55 rs3096130 62.41 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 0.000297 1.53 rs3104704 17.57 logistic AGEiSEX Ml vs control (at entry) 16 0.0002397 1.49 rs3112257 112.38 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0004018 1.27 rs31 12257 112.38 logistic Ml vs no Ml (at entry) 2 0.0004924 1.27 rs3124516 66.13 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 0.0001588 1.47

OO rs3124516 66.13 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0003541 1.47 rs3128625 155.14 logistic AGE:SEX Ml vs control (follow-up) 9 0.0002313 0.71 rs3128625 155.14 logistic Ml vs control (follow-up) 9 0.0003741 0.71 rs317147 90.62 logistic AGEiSEX Ml vs control (at entry) 11 0.0003631 0.73 rs317147 90.62 logistic Ml vs control (at entry) 11 0.0004296 0.73 rs317155 90.61 logistic AGEiSEX Ml vs control (at entry) 11 0.0003719 0.74 rs317155 90.61 logistic AGEiSEX Ml vs no Ml (at entry) 11 0.0003981 0.78 rs317155 90.61 logistic Ml vs no Ml (at entry) 11 0.0004095 0.78 rs317155 90.61 logistic Ml vs control (at entry) 11 0.00049 0.74 rs317174 90.61 logistic GEiAGEiACRiSEX Ml vs control (at entry) 11 0.0003775 0.75 rs318860 66.66 logistic Ml vs control (follow-up) 8 0.0002534 0.65 rs318860 66.66 logistic GEiAGEiACRiSEX Ml vs control (follow-up) 8 0.0004375 0.65 rs318860 66.66 logistic AGEiSEX Ml vs control (follow-up) 8 0.0004712 0.65 rs319011 59.30 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 5 0.0001128 1.31 rs319011 59.30 logistic HBPIGEIAGEISEX Ml vs no Ml (follow-up) 5 0.0001727 1.29 rs330581 153.18 logistic HBPIGEIAGEISEX Ml vs control (follow-up) 2 0.0003054 1.32 rs330582 153.18 logistic HBPIGEIAGEISEX Ml vs control (follow-up) 2 9.22E-05 1.25 rs331742 132.02 logistic AGEISEX Ml vs control (at entry) 5 5.91 E-05 0.62

rs331742 132.02 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 7.76E-05 0.62 rs331742 132.02 logistic Ml vs control (at entry) 5 7.78E-05 0.62 rs331742 132.02 logistic AGE:SEX Ml vs no Ml (at entry) 5 0.0002063 0.69 rs331742 132.02 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.0003087 0.70 rs331742 132.02 logistic Ml vs no Ml (at entry) 5 0.0003103 0.69 rs331742 132.02 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 0.0003545 0.62 rs331742 132.02 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0004853 0.69 rs331783 132.02 logistic AGE:SEX Ml vs control (at entry) 5 3.52E-05 0.61 rs331783 132.02 logistic Ml vs control (at entry) 5 4.14E-05 0.61 rs331783 132.02 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 7.22E-05 0.61 rs331783 132.02 logistic AGE:SEX Ml vs no Ml (at entry) 5 0.0001338 0.68 rs331783 132.02 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 0.0001675 0.61 rs331783 132.02 logistic Ml vs no Ml (at entry) 5 0.0001824 0.68 rs331783 132.02 logistic GE:AGE:SEX Ml vs control (at entry) 5 0.0002347 0.61 rs331783 132.02 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0002508 0.68 rs331783 132.02 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0003298 0.68 rs331783 132.02 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.000348 0.71 rs333531 37.87 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 5 0.0004858 1.29 rs33612 93.68 logistic AGEiSEX Ml vs control (follow-up) 5 0.0004834 0.71 rs33762 69.09 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0001253 0.74 rs33762 69.09 logistic Ml vs no Ml (at entry) 3 0.0001533 0.74 rs33762 69.09 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0001669 0.74 rs33762 69.09 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0001795 0.74 rs33762 69.09 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0003456 0.74 rs33978605 78.51 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 0.000134 1.29 rs33978605 78.51 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.0001744 1.29 rs33978605 78.51 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 0.0002696 1.29 rs33978605 78.51 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 0.0003268 1.41 rs33978605 78.51 logistic GE:AGE:SEX Ml vs control (follow-up) 7 0.000346 1.41 rs33978605 78.51 logistic AGE:SEX Ml vs no Ml (follow-up) 7 0.0004013 1.29 rs34266279 130.85 logistic AGE:SEX Ml vs control (at entry) 7 8.39E-05 2.15 rs34266279 130.85 logistic Ml vs control (at entry) 7 9.80E-05 2.15 rs34266279 130.85 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0002821 2.15 rs34266279 130.85 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 0.0003625 2.15 rs34328214 6.49 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 6 0.0003265 0.79 rs34795027 174.34 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 2 0.0004314 1.33

rs34799743 17.84 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0001421 0.78 rs34799743 17.84 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0003552 0.78 rs34799743 17.84 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0004103 0.78 rs34799743 17.84 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0004372 0.78 rs351737 117.57 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.0004655 0.78 rs35471 124.43 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0003931 1.36 rs35471 124.43 logistic AGEiSEX Ml vs no Ml (follow-up) 12 0.0004637 1.36 rs35471 124.43 logistic Ml vs no Ml (follow-up) 12 0.0004781 1.36 rs35471 124.43 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0004963 1.36 rs35662693 124.90 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 0.0002906 1.45 rs35662693 124.90 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 0.0003026 1.42 rs36017 73.99 logistic AGE:SEX Ml vs control (follow-up) 16 0.0004328 1.39 rs36017 73.99 logistic Ml vs control (follow-up) 16 0.0004834 1.39 rs367719 73.19 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0002466 1.20 rs367719 73.19 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 0.0003369 1.14 rs3734281 133.85 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 6 0.0001665 1.43 rs3734281 133.85 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.0001734 1.39 rs3737845 155.22 logistic Ml vs control (at entry) 1 0.0004329 1.71 rs3737845 155.22 logistic AGE:SEX Ml vs control (at entry) 1 0.0004467 1.71 rs3741599 80.56 logistic AGE:SEX Ml vs control (at entry) 12 0.0003494 1.45 rs3753151 162.80 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 0.0001667 0.80 rs3757971 167.21 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.0003216 1.30 rs3757971 167.21 logistic GE:AGE:SEX Ml vs control (follow-up) 8 0.0004852 1.30 rs3773383 2.16 logistic GE:AGE:SEX Ml vs control (follow-up) 3 0.0002698 0.75 rs3775580 195.50 logistic Ml vs no Ml (follow-up) 4 0.0001908 1.29 rs3775580 195.50 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.000231 1.29 rs3775580 195.50 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0002674 1.29 rs3775580 195.50 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0003579 1.29 rs3775580 195.50 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0004359 1.29 rs3775580 195.50 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0004731 1.29 rs3779258 127.57 logistic AGE:SEX Ml vs control (at entry) 7 0.0001588 1.75 rs3779258 127.57 logistic Ml vs control (at entry) 7 0.0002698 1.75 rs3779258 127.57 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 0.0002885 1.75 rs3780473 56.40 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 0.000356 0.82 rs3780474 56.40 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 0.000464 0.83 rs3781571 124.81 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 4.08E-05 1.28

rs3781571 124.81 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 4.90E-05 1.28 rs3781571 124.81 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0001466 1.28 rs3781571 124.81 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 0.0002051 1.28 rs3781571 124.81 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 0.0003032 1.28 rs3781571 124.81 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0003541 1.28 rs3781571 124.81 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 0.000367 1.28 rs3781571 124.81 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0004263 1.28 rs3785157 74.01 logistic Ml vs control (follow-up) 16 0.0001831 0.69 rs3785157 74.01 logistic AGE:SEX Ml vs control (follow-up) 16 0.0002482 0.69 rs3811924 39.64 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0003292 0.80 rs3820821 46.60 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 1.36E-05 2.08 rs3820821 46.60 logistic Ml vs no Ml (at entry) 2 0.000178 1.81 rs3820821 46.60 logistic Ml vs no Ml (follow-up) 2 0.0002486 1.78 rs3820821 46.60 logistic AGEiSEX Ml vs no Ml (at entry) 2 0.000271 1.81 rs3820821 46.60 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0004016 1.78 rs3821374 63.37 logistic GE:AGE:SEX Ml vs control (at entry) 3 0.0002066 1.48 rs3821374 63.37 logistic Ml vs control (at entry) 3 0.0002756 1.48 κ> rs3821374 63.37 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 3 0.0002758 1.48

2 rs3821374 63.37 logistic AGE:SEX Ml vs control (at entry) 3 0.0003877 1.48 rs3821374 63.37 logistic Ml vs control (follow-up) 3 0.0004048 1.53 rs383659 59.90 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 0.0002134 0.35 rs383659 59.90 logistic AGEiSEX Ml vs no Ml (at entry) 13 0.0002904 0.35 rs383659 59.90 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 13 0.0003433 0.35 rs383659 59.90 logistic GEIAGEISEX Ml vs no Ml (at entry) 13 0.0003977 0.35 rs383659 59.90 logistic Ml vs no Ml (at entry) 13 0.0004382 0.35 rs3844462 17.68 logistic GEiAGEiACRiSEX Ml vs control (at entry) 20 0.0001959 0.67 rs3844462 17.68 logistic GEiAGEiACRiSEX Ml vs control (follow-up) 20 0.0002659 0.67 rs3846820 80.34 logistic AGEiSEX Ml vs control (follow-up) 6 1.09E-05 0.66 rs3846820 80.34 logistic Ml vs control (follow-up) 6 2.25E-05 0.66 rs3846820 80.34 logistic GEiAGEiCRCLiSEX Ml vs control (follow-up) 6 0.0001176 0.66 rs3846820 80.34 logistic GEIAGEISEX Ml vs control (follow-up) 6 0.0001371 0.66 rs3848771 32.96 logistic GEIAGEIACRISEX Ml vs no Ml (follow-up) 20 0.0004906 1.27 rs3848774 32.97 logistic GEIAGEIACRISEX Ml vs no Ml (follow-up) 20 0.0003447 1.28 rs3860187 69.37 logistic GEIAGEIACRISEX Ml vs control (follow-up) 10 9.80E-05 1.57 rs3860187 69.37 logistic GEIAGEICRCLISEX Ml vs control (follow-up) 10 0.0001539 1.57 rs3860187 69.37 logistic Ml vs control (follow-up) 10 0.0002173 1.57

rs3860187 69.37 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0002599 1.57 rs3860187 69.37 logistic AGE:SEX Ml vs control (follow-up) 10 0.0003511 1.57 rs3860187 69.37 logistic GE:AGE:SEX Ml vs control (follow-up) 10 0.0003818 1.57 rs3861988 126.46 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 10 1.24E-05 1.31 rs3861988 126.46 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 10 5.24E-05 1.31 rs3861988 126.46 logistic GE:AGE:SEX Ml vs control (at entry) 10 5.27E-05 1.31 rs3861988 126.46 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 7.64E-05 1.31 rs3861988 126.46 logistic GE:AGE:SEX Ml vs control (follow-up) 10 0.0001152 1.31 rs3861988 126.46 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 10 0.0001736 1.31 rs3862501 98.56 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 0.0001552 1.42 rs3862501 98.56 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0001634 1.42 rs3862501 98.56 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0002259 1.42 rs3862501 98.56 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.0004918 1.42 rs3883317 63.91 logistic AGE:SEX Ml vs control (at entry) 17 8.42E-05 2.18 rs3883317 63.91 logistic Ml vs control (at entry) 17 8.53E-05 2.18 rs3883317 63.91 logistic GE:AGE:SEX Ml vs control (at entry) 17 0.0001536 2.18 rs3883317 63.91 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 17 0.0002611 2.18 rs3909441 89.80 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 1.45E-06 0.18 K) rs3909441 89.80 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 1.54E-06 0.18 rs3909441 89.80 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 1.92E-06 0.18 rs3909441 89.80 logistic Ml vs no Ml (at entry) 1 2.26E-06 0.18 rs3909441 89.80 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 3.17E-06 0.18 rs3909441 89.80 logistic AGE:SEX Ml vs no Ml (at entry) 1 4.40E-06 0.18 rs3909441 89.80 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 1.46E-05 0.28 rs3909441 89.80 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 1.50E-05 0.28 rs3909441 89.80 logistic Ml vs no Ml (follow-up) 1 1.71 E-05 0.28 rs3909441 89.80 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 2.03E-05 0.28 rs3909441 89.80 logistic GE:AGE:SEX Ml vs control (at entry) 1 4.02E-05 0.22 rs3909441 89.80 logistic AGE:SEX Ml vs no Ml (follow-up) 1 4.26E-05 0.28 rs3909441 89.80 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 5.75E-05 0.28 rs3909441 89.80 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 7.48E-05 0.22 rs3909441 89.80 logistic Ml vs control (at entry) 1 0.0001801 0.22 rs3909441 89.80 logistic AGE:SEX Ml vs control (at entry) 1 0.0002403 0.22 rs3909441 89.80 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 0.0003604 0.22 rs3909441 89.80 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.0004292 0.32 rs39095 46.69 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 7 0.0003558 1.27

rs3910518 206.51 logistic AGE:SEX Ml vs control (follow-up) 2 0.0002828 0.69

γS3910518 206.51 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 2 0.0003582 0.69 rs3910518 206.51 logistic GE:AGE:SEX Ml vs control (follow-up) 2 0.0003796 0.69 rs3910518 206.51 logistic Ml vs control (follow-up) 2 0.0004796 0.69 rs3914604 80.34 logistic AGE:SEX Ml vs control (follow-up) 6 2.75E-05 0.67 rs3914604 80.34 logistic Ml vs control (follow-up) 6 5.35E-05 0.67 rs3914604 80.34 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 6 0.0002286 0.67 rs3914604 80.34 logistic GE:AGE:SEX Ml vs control (follow-up) 6 0.000283 0.67 rs3917768 187.49 logistic Ml vs control (at entry) 1 0.000228 1.39 rs3917768 187.49 logistic AGE:SEX Ml vs control (at entry) 1 0.0003185 1.39 rs3920081 79.56 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 16 0.0001843 0.79 rs3924188 171.02 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 6.91 E-05 0.79 rs3924188 171.02 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0004845 0.82 rs3930757 35.37 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 7 0.0001534 1.31 rs3930757 35.37 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 7 0.0002732 1.27 rs3977736 124.81 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0002664 1.31 rs3977736 124.81 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0003675 1.31 rs3977736 124.81 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0003974 1.33 rs3977736 124.81 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0004106 1.30 rs3977736 124.81 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 10 0.0004498 1.33 rs3980634 132.51 logistic AGE:SEX Ml vs control (follow-up) 2 0.0003556 1.51 rs3980634 132.51 logistic Ml vs control (follow-up) 2 0.0004744 1.51 rs3995971 125.56 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0001413 1.56 rs3995971 125.56 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 0.0001515 1.56 rs3995971 125.56 logistic AGE:SEX Ml vs no Ml (follow-up) 3 0.000242 1.56 rs3995971 125.56 logistic GE:AGE:SEX Ml vs no WII (at entry) 3 0.0003387 1.53 rs3995971 125.56 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 0.0003438 1.56 rs3995971 125.56 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0003592 1.53 rs4008332 15.04 logistic AGE:SEX Ml vs control (follow-up) 9 0.0002348 0.58 rs4027132 27.79 logistic Ml vs control (follow-up) 2 0.0003151 0.71 rs4027132 27.79 logistic AGE:SEX Ml vs control (follow-up) 2 0.0003442 0.71 rs4061929 10.93 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 19 0.0003138 0.76 rs4078038 103.35 logistic Ml vs no Ml (at entry) 6 2.62E-05 0.67 rs4078038 103.35 logistic AGE:SEX Ml vs no Ml (at entry) 6 4.29E-05 0.67 rs4078038 103.35 logistic Ml vs no Ml (follow-up) 6 6.99E-05 0.69 rs4078038 103.35 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 7.20E-05 0.67

rs4078038 103.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 8.59E-05 0.67 rs4078038 103.35 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0001225 0.69 rs4078038 103.35 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001848 0.69 rs4078038 103.35 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0002017 0.67 rs4078038 103.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0002208 0.69 rs4078038 103.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0003626 0.67 rs4078038 103.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0003876 0.69 rs407929 74.17 logistic Ml vs control (at entry) 14 5.95E-05 1.57 rs407929 74.17 logistic AGE:SEX Ml vs control (at entry) 14 0.0001138 1.57 rs407929 74.17 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 14 0.0002484 1.57 rs407929 74.17 logistic GE:AGE:SEX Ml vs control (at entry) 14 0.0003206 1.57 rs4085410 45.67 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0001992 1.28 rs4085410 45.67 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0002897 1.27 rs4130030 101.80 logistic AGEiSEX Ml vs control (at entry) 8 0.0001195 1.39 rs4130030 101.80 logistic Ml vs control (at entry) 8 0.0001443 1.39 rs4135067 111.54 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.0003778 1.62 rs4141410 129.82 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 7 4.37E-05 1.47

_K , rs4141410 129.82 logistic AGE:SEX Ml vs control (follow-up) 7 8.50E-05 1.47

£ rs4141410 129.82 logistic GE:AGE:SEX Ml vs control (follow-up) 7 0.0001522 1.47 rs4141410 129.82 logistic Ml vs control (follow-up) 7 0.00016 1.47 rs4141410 129.82 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 0.0002262 1.47 rs414161 95.91 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0004335 0.79 rs4142730 253.39 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0004847 0.73 rs4234177 103.31 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0002588 0.71 rs4236721 60.46 logistic Ml vs no Ml (at entry) 8 6.48E-05 0.28 rs4236721 60.46 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0001005 0.28 rs4236721 60.46 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0001032 0.28 rs4236721 60.46 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 0.0001171 0.28 rs4236721 60.46 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0001266 0.28 rs4236721 60.46 logistic AGE:SEX Ml vs no Ml (at entry) 8 0.0001357 0.28 rs4236721 60.46 logistic Ml vs no Ml (follow-up) 8 0.0003522 0.36 rs4238859 9.85 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 16 0.000421 1.19 rs4238998 103.49 logistic GE:AGE:SEX Ml vs control (at entry) 17 5.93E-05 0.72 rs4238998 103.49 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 17 9.49E-05 0.76 rs4238998 103.49 logistic AGE:SEX Ml vs control (at entry) 17 9.79E-05 0.72 rs4238998 103.49 logistic AGE:SEX Ml vs no Ml (follow-up) 17 0.0001064 0.76

rs4238998 103.49 logistic GE:AGE:SEX Ml vs no Ml (at entry) 17 0.0001123 0.76 rs4238998 103.49 logistic AGE:SEX Ml vs no Ml (at entry) 17 0.0001282 0.76 rs4238998 103.49 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 17 0.0001862 0.72 rs4238998 103.49 logistic Ml vs no Ml (follow-up) 17 0.0001871 0.76 rs4238998 103.49 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 17 0.0001921 0.76 rs4238998 103.49 logistic Ml vs no Ml (at entry) 17 0.0002028 0.76 rs4238998 103.49 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 17 0.0002064 0.76 rs4238998 103.49 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 17 0.0002281 0.76 rs4238998 103.49 logistic GE:AGE:SEX Ml vs control (follow-up) 17 0.0002352 0.73 rs4238998 103.49 logistic Ml vs control (at entry) 17 0.0002459 0.72 rs4238998 103.49 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 17 0.0002842 0.76 rs4238998 103.49 logistic AGEiSEX Ml vs control (follow-up) 17 0.000479 0.73 rs4239268 62.00 logistic Ml vs no Ml (at entry) 17 0.000128 0.58 rs4239268 62.00 logistic . GE:AGE:SEX Ml vs no Ml (at entry) 17 0.0001803 0.58 rs4239268 62.00 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 17 0.0002246 0.58 rs4239268 62.00 logistic AGE:SEX Ml vs no Ml (at entry) 17 0.0002366 0.58 rs4239307 41.83 logistic AGE:SEX Ml vs control (follow-up) 18 0.0001605 1.46 κ> rs4239307 41.83 logistic Ml vs control (follow-up) 18 0.0002614 1.46

<* rs424301 21.04 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 6.29E-05 1.44 rs424301 21.04 logistic GE:AGE:SEX Ml vs control (follow-up) 9 6.94E-05 1.44 rs424301 21.04 logistic Ml vs control (follow-up) 9 9.87E-05 1.44 rs424301 21.04 logistic AGE:SEX Ml vs control (follow-up) 9 0.0001161 1.44 rs424301 21.04 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 9 0.0003314 1.35 rs424301 21.04 logistic GE:AGE:SEX Ml vs control (at entry) 9 0.000445 1.35 rs4243177 104.49 logistic AGE:SEX Ml vs control (at entry) 16 0.0002876 1.38 rs4243177 104.49 logistic Ml vs control (at entry) 16 0.0003258 1.38 rs4244842 67.76 logistic GE:AGE:ACR:SEX Ml vs control (at entry) ^• 11 0.0002144 1.26 rs4244842 67.76 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 11 0.0003789 1.33 rs4272068 67.37 logistic Ml vs no Ml (follow-up) 4 0.0004285 0.70 rs4272068 67.37 logistic AGEiSEX Ml vs no Ml (follow-up) 4 0.0004654 0.70 rs4275832 107.56 logistic GEiAGEiCRCLSEX Ml vs no Ml (follow-up) 15 0.0004893 0.78 rs4277177 59.17 logistic GEiAGEiCRCLSEX Ml vs control (at entry) 12 0.0004689 1.33 rs4293434 53.12 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 17 0.0003469 1.24 rs4296321 41.77 logistic AGEiSEX Ml vs control (follow-up) 18 0.0002121 1.45 rs4296321 41.77 logistic Ml vs control (follow-up) 18 0.0003282 1.45 rs4298502 101.78 logistic AGEiSEX Ml vs control (at entry) 8 0.0001569 1.45

rs4298502 101.78 logistic Ml vs control (at entry) 8 0.0001697 1.45 rs430208 43.38 logistic Ml vs control (follow-up) 16 0.0002944 1.56 rs430208 43.38 logistic AGE:SEX Ml vs control (follow-up) 16 0.0004472 1.56 rs4302323 64.18 logistic Ml vs control (at entry) 3 0.0004019 0.44 rs4310272 66.13 logistic Ml vs no Ml (follow-up) 9 0.0003048 1.39 rs4310272 66.13 logistic AGE:SEX Ml vs no Ml (follow-up) 9 0.0004928 1.39 rs4316363 35.92 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 6.28E-05 1.72 rs4316363 35.92 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 0.0001504 1.72 rs4316363 35.92 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 0.0001556 1.66 rs4316363 35.92 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0002643 1.72 rs4316363 35.92 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.000366 1.66 rs4319862 90.78 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 0.000221 0.79 rs4319862 90.78 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0003802 0.79 rs4341081 151.08 logistic AGE:SEX Ml vs control (follow-up) 7 2.76E-05 0.68 rs4341081 151.08 logistic AGE:SEX Ml vs control (at entry) 7 3.68E-05 0.70 rs4341081 151.08 logistic Ml vs control (follow-up) 7 4.36E-05 0.68 rs4341081 151.08 logistic Ml vs control (at entry) 7 5.93E-05 0.70 rs4341081 151.08 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 7.34E-05 0.68 rs4341081 151.08 logistic GE:AGE:SEX Ml vs control (follow-up) 7 8.18E-05 0.68 rs4341081 151.08 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 9.65E-05 0.70 rs4341081 151.08 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0001285 0.70 rs4342050 103.31 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0003237 0.71 rs4359861 45.08 logistic HBP:GE:AGE:SEX Ml vs no Mi (at entry) 4 3.59E-05 0.76 rs4359861 45.08 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.000216 0.78 rs4359861 45.08 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0002605 0.76 rs4359861 45.08 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0003901 0.76 rs4359861 45.08 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0004318 0.76 rs4361034 99.71 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 19 0.0001448 0.70 rs4361034 99.71 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 19 0.0003325 0.71 rs436760 47.85 logistic Ml vs control (follow-up) 8 6.65E-05 1.51 rs436760 47.85 logistic AGE:SEX Ml vs control (follow-up) 8 0.0001674 1.51 rs436760 47.85 logistic Ml vs control (at entry) 8 0.0002632 1.42 rs436760 47.85 logistic Ml vs no Ml (follow-up) 8 0.0004314 1.30 rs436760 47.85 logistic AGE:SEX Ml vs control (at entry) 8 0.0004895 1.42 rs4370836 4.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 0.000275 1.29 rs4370836 4.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0003012 1.29

rs4380234 212.15 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 0.0004904 0.72 rs4381693 90.82 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0004864 1.22 rs4381975 125.56 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0001863 1.55 rs4381975 125.56 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 0.000198 1.55 rs4381975 125.56 logistic AGE:SEX Ml vs no Ml (follow-up) 3 0.0003123 1.55 rs4381975 125.56 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0004483 1.51 rs4381975 125.56 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 0.0004531 1.55 rs4381975 125.56 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0004713 1.51 rs4382808 4.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0004439 1.28 rs4382808 4.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0004688 1.28 rs4406411 101.80 logistic AGE:SEX Ml vs control (at entry) 8 7.21 E-05 1.41 rs4406411 101.80 logistic Ml vs control (at entry) 8 8.36E-05 1.41 rs4413045 6.62 logistic Ml vs control (at entry) 18 0.0003048 1.38 rs4427899 66.77 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0004379 0.82 rs4432914 168.37 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 5 0.0002426 0.71 rs4438317 104.72 logistic AGE:SEX Ml vs control (follow-up) 16 0.0001203 0.70 rs4438317 104.72 logistic Ml vs control (follow-up) 16 0.0003338 0.70 rs4438317 104.72 logistic GE:AGE:SEX Ml vs control (follow-up) 16 0.0003714 0.70 rs4438317 104.72 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 16 0.0004022 0.70 rs4444654 103.30 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0002585 0.71 rs4447477 53.24 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 17 0.0003687 1.25 rs4460614 208.56 logistic AGE:SEX Ml vs control (at entry) 1 0.0002935 1.92 rs4471623 47.44 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 15 0.0002638 1.32 rs4471623 47.44 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 15 0.0002766 1.31 rs4471623 47.44 logistic GE:AGE:SEX Ml vs no Ml (at entry) 15 0.0002948 1.32 rs4471623 47.44 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 15 0.0003131 1.31 rs4471623 47.44 logistic AGE:SEX Ml vs no Ml (at entry) 15 0.000492 1.32 rs4471623 47.44 logistic Ml vs no Ml (at entry) 15 0.0004979 1.32 rs4497423 130.19 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0002171 1.18 rs4509857 91.21 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 0.0002229 1.42 rs4509857 91.21 logistic GE:AGE:SEX Ml vs control (follow-up) 12 0.0002836 1.42 rs4509857 91.21 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0003145 1.29 rs4509857 91.21 logistic AGE:SEX Ml vs control (follow-up) 12 0.0003879 1.42 rs4509857 91.21 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 0.0004065 1.29 rs4509857 91.21 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0004123 1.28 rs4509857 91.21 logistic GE:AGE:CRCLSEX Ml vs no Ml (at entry) 12 0.0004152 1.29

rs452707 48.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 19 0.0004327 1.22 rs4528272 132.68 logistic AGE:SEX Ml vs control (at entry) 10 2.12E-05 1.66 rs4528272 132.68 logistic Ml vs control (at entry) 10 2.30E-05 1.66 rs4528272 132.68 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 10 0.0001183 1.66 rs4528272 132.68 logistic GE:AGE:CRCLSEX Ml vs control (at entry) 10 0.0001209 1.66 rs4528272 132.68 logistic AGEiSEX Ml vs control (follow-up) 10 0.0001405 1.64 rs4528272 132.68 logistic GE:AGE:SEX Ml vs control (at entry) 10 0.0001589 1.66 rs4528272 132.68 logistic Ml vs control (follow-up) 10 0.0001812 1.64 rs4528272 132.68 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 10 0.0004361 1.64 rs4531484 124.82 logistic AGEiSEX Ml vs control (at entry) 11 0.0004224 1.56 rs453572 118.30 logistic AGEiSEX Ml vs control (at entry) 16 0.0002202 0.73 rs453572 118.30 logistic GEiAGEiCRCLiSEX Ml vs control (at entry) 16 0.0004025 0.73 rs4538346 73.50 logistic AGEiSEX Ml vs control (follow-up) 3 0.0003327 0.68 rs4554206 123.29 logistic AGEiSEX Ml vs no Ml (follow-up) 5 0.0003539 0.79 rs4560339 149.50 logistic Ml vs no Ml (follow-up) 3 3.69E-05 2.50 rs4560339 149.50 logistic Ml vs no Ml (at entry) 3 3.75E-05 2.49 rs4560339 149.50 logistic AGEiSEX Ml vs no Ml (follow-up) 3 4.17E-05 2.50 rs4560339 149.50 logistic AGEiSEX Ml vs no Ml (at entry) 3 4.19E-05 2.49 00 rs4560339 149.50 logistic GEIAGEISEX Ml vs no Ml (at entry) 3 4.70E-05 2.49 rs4560339 149.50 logistic GEIAGEISEX Ml vs no Ml (follow-up) 3 4.95E-05 2.50 rs4560339 149.50 logistic GEIAGEICRCLISEX Ml vs no Ml (follow-up) 3 0.0001959 2.50 rs4560339 149.50 logistic GEIAGEICRCLISEX Ml vs no Ml (at entry) 3 0.0002004 2.49 rs4560339 149.50 logistic GEiAGEiACRiSEX Ml vs no Ml (follow-up) 3 0.0002993 2.50 rs4560339 149.50 logistic GEiAGEiACRiSEX Ml vs no Ml (at entry) 3 0.0003285 2.49 rs4561871 171.01 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 3 0.0001378 0.80 rs4594180 26.40 logistic AGEiSEX Ml vs no Ml (at entry) 14 0.0004534 0.61 rs4603984 125.56 logistic GEIAGEISEX Ml vs no Ml (follow-up) 3 0.0001413 1.56 rs4603984 125.56 logistic GEIAGEICRCLISEX Ml vs no Ml (follow-up) 3 0.0001515 1.56 rs4603984 125.56 logistic AGEISEX Ml vs no Ml (follow-up) 3 0.000242 1.56 rs4603984 125.56 logistic GEIAGEISEX Ml vs no Ml (at entry) 3 0.0003387 1.53 rs4603984 125.56 logistic GEIAGEIACRISEX Ml vs no Ml (follow-up) 3 0.0003438 1.56 rs4603984 125.56 logistic GEIAGEICRCLISEX Ml vs no Ml (at entry) 3 0.0003592 1.53 rs4610242 43.75 logistic Ml vs control (at entry) 3 0.000291 0.71 rs4610413 82.05 logistic AGEISEX Ml vs no Ml (at entry) 4 4.16E-05 0.56 rs4610413 82.05 logistic GEIAGEICRCLISEX Ml vs no Ml (at entry) 4 5.90E-05 0.56 rs4610413 82.05 logistic Ml vs no Ml (at entry) 4 5.91 E-05 0.56

rs4610413 82.05 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 6.36E-05 0.56 rs4610413 82.05 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 8.29E-05 0.56 rs4610413 82.05 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0001031 0.56 rs4610413 82.05 logistic AGE:SEX Ml vs control (at entry) 4 0.0001544 0.55 rs4610413 82.05 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0004231 0.62 rs4614822 66.77 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0003825 0.82 rs4620015 150.12 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0004248 1.34 rs4620015 150.12 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0004264 1.34 rs4620015 150.12 logistic AGE:SEX Ml vs no Ml (at entry) 5 0.0004505 1.34 rs4635681 169.81 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 0.0004852 0.72 rs4645337 7.25 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 0.0004824 0.65 rs4645933 66.12 logistic AGE:SEX Ml vs control (follow-up) 11 0.0001126 1.42 rs4645933 66.12 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0002866 1.28 rs4645933 66.12 logistic Ml vs control (follow-up) 11 0.0003653 1.42 rs4654534 8.90 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.0002442 2.46 rs4655625 99.31 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 8.06E-05 0.66 rs4655625 99.31 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.000111 0.66 rs4655625 99.31 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 0.0001329 0.64 rs4655625 99.31 logistic AGE:SEX Ml vs control (at entry) 1 0.0001939 0.66 rs4655625 99.31 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.0002 0.64 rs4655625 99.31 logistic AGE:SEX Ml vs control (follow-up) 1 0.0003199 0.64 rs4655625 99.31 logistic Ml vs control (at entry) 1 0.0004201 0.66 rs4655641 99.31 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0001961 0.67 rs4655641 99.31 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0002265 0.67 rs4655641 99.31 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 0.0002311 0.65 rs4655641 99.31 logistic GE:AGE:SEX Ml vs control (follow-up) 1 0.0002919 0.65 rs4658439 277.40 logistic Ml vs control (at entry) 1 0.0004345 0.74 rs4663955 256.37 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 0.0004904 0.80 rs4664865 161.49 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0004581 0.55 rs4665969 46.84 logistic AGE:SEX Ml vs control (at entry) 2 0.0003133 0.75 rs4669342 19.56 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 5.96E-05 1.35 rs4673823 210.98 logistic AGE:SEX Ml vs control (follow-up) 2 9.18E-05 0.67 rs4673823 210.98 logistic Ml vs control (follow-up) 2 9.91 E-05 0.67 rs4673823 210.98 logistic GE:AGE:SEX Ml vs control (follow-up) 2 0.0001747 0.67 rs4673823 210.98 logistic GE:AGE:CRCLSEX Ml vs control (follow-up) 2 0.0001818 0.67 rs4673823 210.98 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 2 0.0003477 0.67

rs4676814 137.09 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 0.0003662 0.79 rs4676814 . 137.09 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0004197 0.79 rs4677304 103.32 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0003894 0.71 rs4679840 172.27 logistic AGE:SEX Ml vs control (at entry) 3 0.0001575 1.55 rs4679840 172.27 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0002277 1.38 rs4679840 172.27 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0002762 1.38 rs4679840 172.27 logistic Ml vs control (at entry) 3 0.0002942 1.55 rs4679840 172.27 logistic AGE:SEX Ml vs no Ml (follow-up) 3 0.0003878 1.35 rs4679840 172.27 logistic Ml vs no Ml (at entry) 3 0.0004428 1.38 rs4679840 172.27 logistic AGE:SEX Ml vs control (follow-up) 3 0.0004461 1.58 rs4679840 172.27 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0004807 1.38 rs4689651 16.32 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0003653 1.34 rs4689651 16.32 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0003922 1.34 rs4693142 95.43 logistic Ml vs no Ml (at entry) 4 0.0004958 0.74 rs4693142 95.43 logistic AGE:SEX Ml vs no Ml (at entry) 4 0.0004959 0.74 rs4693571 91.98 logistic Ml vs no Ml (follow-up) 4 3.45E-05 1.64 rs4693571 91.98 logistic AGE:SEX Ml vs no Ml (follow-up) 4 4.45E-05 1.64 rs4693571 91.98 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0001167 1.64 rs4693571 91.98 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.000126 1.64 rs4693571 91.98 logistic AGE:SEX Ml vs control (at entry) 4 0.0001724 1.84 rs4693571 91.98 logistic Ml vs control (at entry) 4 0.0001904 1.84 rs4693571 91.98 logistic Ml vs no Ml (at entry) 4 0.0002799 1.55 rs4693571 91.98 logistic AGE:SEX Ml vs control (follow-up) 4 0.0003132 1.94 rs4693571 91.98 logistic Ml vs control (follow-up) 4 0.0003306 1.94 rs4693571 91.98 logistic AGE:SEX Ml vs no Ml (at entry) 4 0.0003437 1.55 rs4702266 12.59 logistic AGE:SEX Ml vs control (at entry) 5 0.0002083 0.72 rs4702266 12.59 logistic Ml vs control (at entry) 5 0.0002932 0.72 rs4705283 150.01 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 0.0002004 0.82 rs4705698 123.27 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.0003021 0.78 rs4705698 123.27 logistic Ml vs no Ml (follow-up) 5 0.0004215 0.78 rs4705710 123.46 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.000176 1.29 rs4705710 123.46 logistic Ml vs no Ml (follow-up) 5 0.0002374 1.29 rs470588 156.33 logistic AGEiSEX Ml vs control (at entry) 12 0.0001191 1.54 rs470588 156.33 logistic Ml vs control (at entry) 12 0.000173 1.54 rs470588 156.33 logistic AGEiSEX Ml vs control (follow-up) 12 0.0002025 1.59 rs470588 156.33 logistic Ml vs control (follow-up) 12 0.0003252 1.59

rs470588 156.33 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0003945 1.54 rs470588 156.33 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 0.000456 1.59 rs4710333 80.32 logistic AGEiSEX Ml vs control (follow-up) 6 3.24E-05 0.67 rs4710333 80.32 logistic Ml vs control (follow-up) 6 5.81 E-05 0.67 rs4710333 80.32 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 6 0.0002351 0.67 rs4710333 80.32 logistic GE:AGE:SEX Ml vs control (follow-up) 6 0.0002982 0.67 rs4711764 68.08 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0003517 0.80 rs4713899 48.22 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 6 0.0004989 1.58 rs4715939 27.41 logistic AGE:SEX Ml vs control (follow-up) 6 0.0003559 0.72 rs4715939 27.41 logistic Ml vs control (follow-up) 6 0.0004688 0.72 rs4719813 39.94 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 7 0.0003837 1.39 rs4719813 39.94 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 0.0004935 1.39 rs4737321 90.24 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 0.0004854 0.59 rs4750480 35.92 logistic AGEiSEX Ml vs control (follow-up) 10 0.0003922 0.70 rs4761127 93.73 logistic Ml vs control (follow-up) 12 0.0001815 0.70 rs4761127 93.73 logistic Ml vs control (at entry) 12 0.0001854 0.72 rs4761127 93.73 logistic AGE:SEX Ml vs control (at entry) 12 0.0002842 0.72

K. rs4761127 93.73 logistic AGE:SEX Ml vs control (follow-up) 12 0.0003934 0.70

2 rs4761350 85.69 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.0002162 0.77 rs4765033 143.72 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 4.89E-05 1.31 rs4765033 143.72 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 12 0.0004238 1.24 rs4766591 118.40 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0003093 1.21 rs4766601 118.53 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 0.0003125 0.87 rs4766691 120.88 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 0.0001894 0.79 rs4766691 120.88 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 0.0002012 0.77 rs4766691 120.88 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0002076 0.79 rs4766691 120.88 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0002293 0.79 rs4766691 120.88 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0003116 0.79 rs4766691 120.88 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.0004488 0.79 rs4766720 121.54 logistic AGE:SEX Ml vs no Ml (follow-up) 12 0.000243 0.79 rs476838 87.18 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0004177 0.59 rs476838 87.18 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0004895 0.60 rs4769856 20.56 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 13 0.0004252 1.29 rs4771651 103.02 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 13 0.0001731 1.40 rs4771651 103.02 logistic GE:AGE:SEX Ml vs control (follow-up) 13 0.0002378 1.40 rs4775276 53.26 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 15 0.0003984 1.23

rs4775276 53.26 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 15 0.0004746 1.31 rs4785325 58.45 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 16 2.21 E-05 1.24 rs4788933 103.49 logistic GE:AGE:SEX Ml vs control (at entry) 17 6.94E-05 0.73 rs4788933 103.49 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 17 7.21 E-05 0.77 rs4788933 103.49 logistic GE:AGE:SEX Ml vs no Ml (at entry) 17 9.22E-05 0.77 rs4788933 103.49 logistic AGE:SEX Ml vs no Ml (follow-up) 17 0.0001184 0.77 rs4788933 103.49 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 17 0.0001272 0.77 rs4788933 103.49 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 17 0.0001566 0.77 rs4788933 103.49 logistic AGE:SEX Ml vs no Ml (at entry) 17 0.0001615 0.77 rs4788933 103.49 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 17 0.0001621 0.77 rs4788933 103.49 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 17 0.0001748 0.73 rs4788933 103.49 logistic AGEiSEX Ml vs control (at entry) 17 0.0001762 0.73 rs4788933 103.49 logistic Ml vs no Ml (follow-up) 17 0.0002069 0.77 rs4788933 103.49 logistic GE:AGE:SEX Ml vs control (follow-up) 17 0.0002086 0.74 rs4788933 103.49 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 17 0.0002309 0.77 rs4788933 103.49 logistic Ml vs no Ml (at entry) 17 0.0002534 0.77 rs4788933 103.49 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 17 0.0003968 0.74 rs4788933 103.49 logistic Ml vs control (at entry) 17 0.0004209 0.73 K) rs4797877 1.49 logistic AGEiSEX Ml vs control (follow-up) 18 0.000378 0.73 rs480039 251.16 logistic GEIAGEISEX Ml vs control (follow-up) 1 0.0001561 0.71 rs480039 251.16 logistic GEiAGEiCRCLiSEX Ml vs control (follow-up) 1 0.0003099 0.71 rs4801417 99.71 logistic HBPIGEIAGEISEX Ml vs no Ml (follow-up) 19 0.0001107 0.67 rs4801417 99.71 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 19 0.0002749 0.68 rs4810366 58.30 logistic GEiAGEiACRiSEX Ml vs control (follow-up) 20 0.0001777 0.71 rs4810366 58.30 logistic GEiAGEiACRiSEX Ml vs no Ml (follow-up) 20 0.0001826 0.78 rs4810366 58.30 logistic GEIAGEIACRISEX Ml vs no Ml (at entry) 20 0.000237 0.79 rs4812631 58.30 logistic GEIAGEIACRISEX Ml vs control (follow-up) 20 0.0001228 0.71 rs4832333 105.70 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 2 0.0003549 1.24 rs4839826 103.33 logistic Ml vs no Ml (at entry) 6 0.0003015 0.74 rs4839826 103.33 logistic Ml vs no Ml (follow-up) 6 0.0003677 0.75 rs4842244 157.84 logistic AGEISEX Ml vs no Ml (at entry) 9 0.0001257 0.74 rs4842244 157.84 logistic AGEiSEX Ml vs control (at entry) 9 0.0001595 0.70 rs4842244 157.84 logistic Ml vs no Ml (at entry) 9 0.0001758 0.74 rs4842244 157.84 logistic AGEiSEX Ml vs no Ml (follow-up) 9 0.0002009 0.75 rs4842244 157.84 logistic GEIAGEICRCLISEX Ml vs no Ml (at entry) 9 0.0002339 0.74 rs4842244 157.84 logistic GEIAGEISEX Ml vs no Ml (at entry) 9 0.0002666 0.74

rs4842244 157.84 logistic Ml vs control (at entry) 9 0.0002916 0.70 rs4842244 157.84 logistic Ml vs no Ml (follow-up) 9 0.0003021 0.75 rs4842244 157.84 logistic GE:AGE:CRCL:SEξX Ml vs no Ml (follow-up) 9 0.0003248 0.75 rs4842244 157.84 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0003727 0.75 rs4842244 157.84 logistic GE:AGE:SEX Ml vs control (at entry) 9 0.0004267 0.70 rs4849143 123.09 logistic Ml vs control (follow-up) 2 0.000273 1.45 rs4849143 123.09 logistic AGE:SEX Ml vs control (follow-up) 2 0.0004361 1.45 rs4850945 112.33 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0003805 0.78 rs4850945 112.33 logistic Ml vs no Ml (at entry) 2 0.0003884 0.78 rs4851365 112.34 logistic Ml vs no Ml (at entry) 2 0.0004012 0.78 rs4851365 112.34 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0004225 0.78 rs4851422 113.09 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 2 6.89E-05 1.43 rs4851422 113.09 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 2 0.0003038 1.43 rs4851422 113.09 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0004151 1.33 rs4851422 113.09 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0004233 1.33 rs4851422 113.09 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 0.0004745 1.33 rs4856502 111.43 logistic AGE:SEX Ml vs control (at entry) 3 0.0003687 1.77 rs4857242 113.69 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 0.0004235 1.23 rs4866542 7.26 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 0.0003657 0.64 rs4866542 7.26 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 5 0.0004794 0.62 rs4869544 54.34 logistic Ml vs no Ml (at entry) 5 3.15E-06 0.48 rs4869544 54.34 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 4.29E-06 0.44 rs4869544 54.34 logistic AGE:SEX Ml vs no Ml (at entry) 5 7.77E-06 0.48 rs4869544 54.34 logistic Ml vs control (at entry) 5 8.34E-06 0.44 rs4869544 54.34 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 1.13E-05 0.48 rs4869544 54.34 logistic AGE:SEX Ml vs control (at entry) 5 1.14E-05 0.44 rs4869544 54.34 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 5 1.27E-05 0.48 rs4869544 54.34 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 1.47E-05 0.48 rs4869544 54.34 logistic Ml vs no Ml (follow-up) 5 2.56E-05 0.53 rs4869544 54.34 logistic GE:AGE:SEX Ml vs control (at entry) 5 3.16E-05 0.44 rs4869544 54.34 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 6.66E-05 0.44 rs4869544 54.34 logistic AGEiSEX Ml vs no Ml (follow-up) 5 7.10E-05 0.53 rs4869544 54.34 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 7.31 E-05 0.48 rs4869544 54.34 logistic AGE:SEX Ml vs control (follow-up) 5 8.99E-05 0.48 rs4869544 54.34 logistic Ml vs control (follow-up) 5 9.50E-05 0.48 rs4869544 54.34 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 9.68E-05 0.53

rs4869544 54.34 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0001223 0.53 rs4869544 54.34 logistic GE:AGE:SEX Ml vs control (follow-up) 5 0.0004287 0.48 rs4870752 126.17 logistic AGE:SEX Ml vs no Ml (follow-up) 8 6.95E-05 1.34 rs4870752 126.17 logistic Ml vs no Ml (follow-up) 8 0.0001044 1.34 rs4870752 126.17 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0001472 1.34 rs4870752 126.17 logistic AGE:SEX Ml vs no Ml (at entry) 8 0.0001655 1.33 rs4870752 126.17 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 8 0.0001858 1.34 rs4870752 126.17 logistic Ml vs no Ml (at entry) 8 0.000229 1.33 rs4870752 126.17 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0003066 1.34 rs4870752 126.17 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0003927 1.33 rs4870752 126.17 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0004964 1.33 rs4876626 124.53 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0004109 0.79 rs4876626 124.53 logistic GE:AGE:SEX Ml vs control (at entry) 8 0.0004424 0.74 rs4876626 124.53 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0004749 0.79 rs4876626 124.53 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.000482 0.79 rs4876626 124.53 logistic AGE:SEX Ml vs control (at entry) 8 0.0004942 0.74 rs4878520 56.77 logistic AGE:SEX Ml vs no Ml (at entry) 9 0.0001057 0.76

^ rs4878520 56.77 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 9 0.0001306 0.76

S rs4878520 56.77 logistic Ml vs no Ml (at entry) 9 0.0001326 0.76 rs4878520 56.77 logistic GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0001336 0.76 rs4878520 56.77 logistic AGE:SEX Ml vs no Ml (follow-up) 9 0.0002218 0.78 rs4878520 56.77 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 9 0.0002734 0.78 rs4878520 56.77 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0002868 0.78 rs4878520 56.77 logistic Ml vs no Ml (follow-up) 9 0.0002876 0.78 rs4878520 56.77 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0003167 0.76 rs488131 43.41 logistic Ml vs no Ml (at entry) 16 0.0004451 1.40 rs4905157 109.44 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) ^• 14 0.0004743 0.68 rs490767 61.77 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 0.00013 0.70 rs490767 61.77 logistic AGE:SEX Ml vs control (at entry) 8 0.0001649 0.70 rs490767 61.77 logistic Ml vs control (at entry) 8 0.0002245 0.70 rs490767 61.77 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0002291 0.76 rs490767 61.77 logistic AGE:SEX Ml vs no Ml (at entry) 8 0.0002546 0.76 rs490767 61.77 logistic GE:AGE:SEX Ml vs control (at entry) 8 0.0002728 0.70 rs490767 61.77 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0003269 0.76 rs4910325 17.82 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0001658 0.54 rs4910325 17.82 logistic Ml vs no Ml (at entry) 11 0.0002045 0.54

rs4910325 17.82 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 0.0002394 0.54 rs4910325 17.82 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 0.0003196 0.54 rs4910325 17.82 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 11 0.0003583 0.54 rs4910325 17.82 logistic AGE:SEX Ml vs no Ml (follow-up) 11 0.0004225 0.58 rs4920424 41.66 logistic Ml vs no Ml (at entry) 1 1.84E-05 0.16 rs4920424 41.66 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 1.88E-05 0.16 rs4920424 41.66 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 2.20E-05 0.16 rs4920424 41.66 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 2.30E-05 0.16 rs4920424 41.66 logistic AGE:SEX Ml vs no Ml (at entry) 1 3.32E-05 0.16 rs4920424 41.66 logistic Ml vs no Ml (follow-up) 1 3.78E-05 0.23 rs4920424 41.66 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 4.07E-05 0.16 rs4920424 41.66 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 4.76E-05 0.23 rs4920424 41.66 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 6.04E-05 0.23 rs4920424 41.66 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 6.08E-05 0.23 rs4920424 41.66 logistic AGE:SEX Ml vs no Ml (follow-up) 1 8.64E-05 0.23 rs4920424 41.66 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0001422 0.23 rs4920424 41.66 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0002563 0.20 rs4920424 41.66 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0003694 0.20

VO rs493490 94.18 logistic AGE:SEX Ml vs control (at entry) 11 0.0003867 1.37 rs493490 94.18 logistic Ml vs control (at entry) 11 0.0004098 1.37 rs4937159 127.81 logistic GE:AGE:SEX Ml vs control (at entry) 11 0.0002321 0.63 rs4937159 127.81 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 11 0.0003514 0.63 rs4938648 103.82 logistic GE:AGE:SEX Ml vs control (follow-up) 11 0.0003425 0.74 rs4938648 103.82 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 11 0.0003521 0.74 rs4940533 90.86 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 5.35E-05 0.76 rs4940533 90.86 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 9.49E-05 0.76 rs4940533 90.86 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0001113 0.76 rs4940533 90.86 logistic Ml vs no Ml (follow-up) 18 0.000113 0.76 rs4940533 90.86 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 0.0001716 0.76 rs4940533 90.86 logistic AGE:SEX Ml vs no Ml (follow-up) 18 0.000177 0.76 rs4940533 90.86 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0001985 0.78 rs4940533 90.86 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.000307 0.78 rs4940533 90.86 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0003568 0.78 rs4940533 90.86 logistic Ml vs no Ml (at entry) 18 0.0004015 0.78 rs4940533 90.86 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0004705 0.78 rs4941312 81.60 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0001562 1.90

rs4941312 81.60 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0002334 1.90 rs4941312 81.60 logistic AGE:SEX Ml vs control (at entry) 18 0.0003203 1.90 rs4941312 81.60 logistic Ml vs control (at entry) 18 0.000421 1.90 rs4943980 89.29 logistic AGE:SEX Ml vs control (at entry) 11 8.67E-05 1.39 rs4943980 89.29 logistic AGEiSEX Ml vs no Ml (follow-up) 11 0.0001091 1.29 rs4943980 89.29 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0001503 1.29 rs4943980 89.29 logistic Ml vs control (at entry) 11 0.0001575 1.39 rs4943980 89.29 logistic Ml vs no Ml (follow-up) 11 0.0002267 1.29 rs4943980 89.29 logistic Ml vs no Ml (at entry) 11 0.0002702 1.29 rs4952521 61.97 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 2 0.0001325 1.39 rs4952521 61.97 logistic AGEiSEX Ml vs control (follow-up) 2 0.0003115 1.39 rs4952521 61.97 logistic Ml vs control (follow-up) 2 0.000373 1.39 rs4952521 61.97 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 2 0.0004409 1.39 rs4952521 61.97 logistic GE:AGE:SEX Ml vs control (follow-up) 2 0.0004924 1.39 rs4968008 43.44 logistic Ml vs control (follow-up) 16 0.0003816 1.55 rs4968013 43.48 logistic Ml vs no Ml (at entry) 16 0.0003169 1.40 rs4968013 43.48 logistic Ml vs no Ml (follow-up) 16 0.0003474 1.40 rs4968013 43.48 logistic AGE:SEX Ml vs no Ml (at entry) 16 0.000373 1.40

VO rs4968013 43.48 logistic AGE:SEX Ml vs no Ml (follow-up) 16 0.0004191 1.40 rs4982731 14.60 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 14 0.0004522 1.36 rs4995246 80.70 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 4 0.0004501 1.31 rs500397 36.16 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 0.0004782 1.58 rs509759 127.91 logistic Ml vs control (at entry) 11 0.0003189 0.73 rs509759 127.91 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 11 0.0004093 0.73 rs509759 127.91 logistic GE:AGE:SEX Ml vs control (at entry) 11 0.0004281 0.73 rs518647 45.49 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 13 0.000151 2.06 rs518647 45.49 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 13 0.0001985 2.06 rs518647 45.49 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 13 0.0002456 2.06 rs518647 45.49 logistic Ml vs no Ml (follow-up) 13 0.0003092 2.06 rs522030 94.39 logistic AGE:SEX Ml vs control (at entry) 11 0.0002636 1.41 rs522030 94.39 logistic Ml vs control (at entry) 11 0.000266 1.41 rs522740 94.39 logistic Ml vs control (at entry) 11 0.0001916 1.42 rs522740 94.39 logistic AGE:SEX Ml vs control (at entry) 11 0.0001945 1.42 rs528484 62.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0002466 1.60 rs528484 62.06 logistic HBP:GE:AGE:SEX Ml vs no WII (follow-up) 8 0.0003453 1.58 rs529423 62.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0001393 1.63

rs529423 62.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0001967 1.61 rs529423 62.06 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 8 0.0003124 1.63 rs529423 62.06 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0004162 1.63 rs529423 62.06 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0004408 1.61 rs529584 137.52 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0002666 0.65 rs529584 137.52 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.0003027 0.65 rs549466 124.85 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 3.68E-05 1.24 rs549466 124.85 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0001216 1.22 rs558582 111.96 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0004479 1.26 rs566164 117.57 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.0001982 0.77 rs566817 110.13 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0004547 0.85 rs568682 110.13 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0004386 0.85 rs569694 127.85 logistic GE:AGE:SEX Ml vs control (at entry) 11 0.0001494 0.70 rs569694 127.85 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 11 0.0002071 0.70 rs5742878 14.16 logistic Ml vs no Ml (at entry) 14 1.10E-05 0.48 rs5742878 14.16 logistic AGE:SEX Ml vs no Ml (at entry) 14 2.55E-05 0.48 rs5742878 14.16 logistic GE:AGE:SEX Ml vs no Ml (at entry) 14 2.60E-05 0.48 rs5742878 14.16 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 14 3.19E-05 0.48

VO rs5742878 14.16 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 14 3.76E-05 0.48 rs5742878 14.16 logistic AGE:SEX Ml vs control (at entry) 14 6.11 E-05 0.47 rs5742878 14.16 logistic Ml vs control (at entry) 14 8.51 E-05 0.47 rs5742878 14.16 logistic Ml vs no Ml (follow-up) 14 0.0001074 0.54 rs5742878 14.16 logistic GE:AGE:SEX Ml vs control (at entry) 14 0.0001182 0.47 rs5742878 14.16 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 14 0.0001531 0.48 rs5742878 14.16 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 14 0.0002509 0.54 rs5742878 14.16 logistic AGE:SEX Ml vs no Ml (follow-up) 14 0.0002649 0.54 rs5742878 14.16 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 14 0.00027 0.47 rs5742878 14.16 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 14 0.0003488 0.54 rs5742878 14.16 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 14 0.0003649 0.54 rs5765397 52.54 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 22 6.35E-05 1.29 rs5765397 52.54 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 22 0.0001578 1.27 rs5765397 52.54 logistic AGE:SEX Ml vs no Ml (follow-up) 22 0.0002171 1.29 rs5765397 52.54 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 22 0.0002453 1.29 rs5765397 52.54 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 22 0.0002896 1.29 rs5765397 52.54 logistic Ml vs no Ml (follow-up) 22 0.0002924 1.29 rs5765397 52.54 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 22 0.000327 1.29

rs5765397 52.54 logistic AGE:SEX Ml vs no Ml (at entry) 22 0.0004718 1.27 rs5765398 52.54 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 22 5.57E-05 1.29 rs5765398 52.54 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 22 0.0001407 1.28 rs5765398 52.54 logistic AGE:SEX Ml vs no Ml (follow-up) 22 0.0001946 1.29 rs5765398 52.54 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 22 0.0002336 1.29 rs5765398 52.54 logistic Ml vs no Ml (follow-up) 22 0.0002616 1.29 rs5765398 52.54 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 22 0.0002627 1.29 rs5765398 52.54 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 22 0.0002921 1.29 rs5765398 52.54 logistic AGE:SEX Ml vs no Ml (at entry) 22 0.000429 1.28 rs5765425 52.55 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 22 5.35E-05 1.29 rs5765425 52.55 logistic AGE:SEX Ml vs no Ml (follow-up) 22 8.75E-05 1.29 rs5765425 52.55 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 22 0.0001021 1.30 rs5765425 52.55 logistic AGE:SEX Ml vs no Ml (at entry) 22 0.0001045 1.30 rs5765425 52.55 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 22 0.0001464 1.29 rs5765425 52.55 logistic Ml vs no Ml (follow-up) 22 0.0001737 1.29 rs5765425 52.55 logistic Ml vs no Ml (at entry) 22 0.0001858 1.30 rs5765425 52.55 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 22 0.0002077 1.30

KJ rs5765425 52.55 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 22 0.0002169 1.29

∞ rs5765425 52.55 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 22 0.0002904 1.29 rs5765425 52.55 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 22 0.0003115 1.30 rs5765425 52.55 logistic GE:AGE:SEX Ml vs no Ml (at entry) 22 0.0004194 1.30 rs584125 83.76 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 0.0001788 1.42 rs584125 83.76 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0001988 1.40 rs584125 83.76 logistic AGE:SEX Ml vs control (at entry) 18 0.000203 1.40 rs584125 83.76 logistic GE:AGE:SEX Ml vs control (follow-up) 18 0.000297 1.42 rs584125 83.76 logistic AGE:SEX Ml vs control (follow-up) 18 0.0003083 1.42 rs584125 83.76 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0004173 1.40 rs589540 142.83 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 0.0003485 0.66 rs589540 142.83 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0003725 0.66 rs601305 36.46 logistic GE:AGE:CRCLSEX Ml vs no Ml (at entry) 11 7.90E-05 0.59 rs601305 36.46 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 11 8.56E-05 0.59 rs601305 36.46 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 11 0.0001098 0.60 rs601305 36.46 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0001267 0.60 rs601305 36.46 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 0.000154 0.59 rs601305 36.46 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0002074 0.60 rs601305 36.46 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 11 0.0002412 0.60

rs601305 36.46 logistic Ml vs no Ml (at entry) 11 0.0002786 0.59 rs601305 36.46 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0002915 0.59 rs601305 36.46 logistic Ml vs no Ml (follow-up) 11 0.0003402 0.60 rs601305 36.46 logistic AGE:SEX Ml vs no Ml (follow-up) 11 0.0003594 0.60 rs6014814 86.14 logistic GE:AGE:SEX Ml vs control (follow-up) 20 3.70E-05 0.67 rs6014814 86.14 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 20 4.62E-05 0.67 rs6014814 86.14 logistic GE:AGE:SEX Ml vs control (at entry) 20 5.10E-05 0.70 rs6014814 86.14 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 20 7.27E-05 0.70 rs6014814 86.14 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 8.26E-05 0.74 rs6014814 86.14 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 8.55E-05 0.74 rs6014814 86.14 logistic Ml vs no Ml (follow-up) 20 8.56E-05 0.74 rs6014814 86.14 logistic Ml vs control (follow-up) 20 9.04E-05 0.67 rs6014814 86.14 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 20 9.04E-05 0.74 rs6014814 86.14 logistic Ml vs no Ml (at entry) 20 0.0001083 0.74 rs6014814 86.14 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 20 0.00011 0.74 rs6014814 86.14 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 20 0.0001156 0.74 rs6014814 86.14 logistic GE:AGE:SEX Ml vs no Ml (at entry) 20 0.0001359 0.74 rs6014814 86.14 logistic AGE:SEX Ml vs no Ml (follow-up) 20 0.0001441 0.74

VO vo rs6014814 86.14 logistic AGE:SEX Ml vs control (follow-up) 20 0.0001622 0.67 rs6014814 86.14 logistic AGE:SEX Ml vs no Ml (at entry) 20 0.0001692 0.74 rs6014814 86.14 logistic Ml vs control (at entry) 20 0.0001911 0.70 rs6014814 86.14 logistic AGE:SEX Ml vs control (at entry) 20 0.0002255 0.70 rs6016864 58.25 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 20 0.0003855 0.73 rs6016864 58.25 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 0.0004278 0.79 rs6031659 61.10 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 20 0.0001054 1.42 rs6031659 61.10 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 20 0.0002615 1.34 rs6032919 28.14 logistic AGE:SEX Ml vs control (at entry) 20 0.0004187 1.34 rs6040171 28.43 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 0.0002427 1.27 rs6040171 28.43 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 0.0003385 1.26 rs6040171 28.43 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 20 0.0003686 1.27 rs6041841 32.96 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 0.0001302 1.31 rs6041841 32.96 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 20 0.000242 1.31 rs6041841 32.96 logistic Ml vs no Ml (follow-up) 20 0.0002983 1.31 rs6041841 32.96' logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 0.0003337 1.30 rs6041841 32.96 logistic AGE:SEX Ml vs no Ml (follow-up) 20 0.0003506 1.31 rs6041841 32.96 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 20 0.0003814 1.31

rs6041841 32.96 logistic GE:AGE:SEX Ml vs no Ml (at entry) 20 0.0004108 1.30 rs6062419 103.63 logistic Ml vs no Ml (follow-up) 20 0.0003411 0.71 rs6065525 58.28 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 0.0002029 0.78 rs6065525 58.28 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 20 0.0002161 0.71 rs6065525 58.28 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 0.0002556 0.79 rs6069858 86.14 logistic GE:AGE:SEX Ml vs control (follow-up) 20 3.27E-05 0.66 rs6069858 86.14 logistic GE:AGE:SEX Ml vs control (at entry) 20 3.98E-05 0.69 rs6069858 86.14 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 20 4.09E-05 0.66 rs6069858 86.14 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 20 5.68E-05 0.69 rs6069858 86.14 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 6.24E-05 0.73 rs6069858 86.14 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 6.46E-05 0.73 rs6069858 86.14 logistic Ml vs no Ml (follow-up) 20 6.83E-05 0.73 rs6069858 86.14 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 20 6.91 E-05 0.73 rs6069858 86.14 logistic Ml vs control (follow-up) 20 8.39E-05 0.66 rs6069858 86.14 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 20 8.42E-05 0.73 rs6069858 86.14 logistic Ml vs no Ml (at entry) 20 8.67E-05 0.73 rs6069858 86.14 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 20 8.84E-05 0.73 rs6069858 86.14 logistic GE:AGE:SEX Ml vs no Ml (at entry) 20 0.0001041 0.73

O O rs6069858 86.14 logistic AGE:SEX Ml vs no Ml (follow-up) 20 0.0001148 0.73 rs6069858 86.14 logistic AGE:SEX Ml vs no Ml (at entry) 20 0.0001356 0.73 rs6069858 86.14 logistic AGE:SEX Ml vs control (follow-up) 20 0.0001501 0.66 rs6069858 86.14 logistic Ml vs control (at entry) 20 0.0001562 0.69 rs6069858 86.14 logistic AGE:SEX Ml vs control (at entry) 20 0.000184 0.69 rs6069864 86.15 logistic GE:AGE:SEX Ml vs control (follow-up) 20 2.02E-05 0.66 rs6069864 86.15 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 2.40E-05 0.72 rs6069864 86.15 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 2.49E-05 0.72 rs6069864 86.15 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 20 2.52E-05 0.66 rs6069864 86.15 logistic GE:AGE:SEX Ml vs control (at entry) 20 2.60E-05 0.69 rs6069864 86.15 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 20 3.06E-05 0.72 rs6069864 86.15 logistic Ml vs no Ml (follow-up) 20 3.07E-05 0.72 rs6069864 86.15 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 20 3.70E-05 0.72 rs6069864 86.15 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 20 3.71 E-05 0.69 rs6069864 86.15 logistic Ml vs no Ml (at entry) 20 3.89E-05 0.72 rs6069864 86.15 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 20 4.15E-05 0.72 rs6069864 86.15 logistic GE:AGE:SEX Ml vs no Ml (at entry) 20 4.86E-05 0.72 rs6069864 86.15 logistic AGE:SEX Ml vs no Ml (follow-up) 20 5.48E-05 0.72

rs6069864 86.15 logistic Ml vs control (follow-up) 20 5.99E-05 0.66 rs6069864 86.15 logistic AGE:SEX Ml vs no Ml (at entry) 20 6.42E-05 0.72 rs6069864 86.15 logistic AGEiSEX Ml vs control (follow-up) 20 9.21 E-05 0.66 rs6069864 86.15 logistic Ml vs control (at entry) 20 0.0001197 0.69 rs6069864 86.15 logistic AGE:SEX Ml vs control (at entry) 20 0.0001234 0.69 rs6069864 86.15 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 20 0.0004716 0.72 rs6072819 58.25 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 20 0.0001814 0.73 rs6072819 58.25 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 0.000328 0.79 rs607985 63.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 1.95E-05 1.28 rs607985 63.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 9.23E-05 1.25 rs607985 63.58 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0004957 1.28 rs6080358 38.70 logistic GE:AGE:SEX Ml vs no Ml (at entry) 20 0.0001599 0.71 rs6080358 38.70 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 20 0.000166 0.71 rs6080358 38.70 logistic Ml vs no Ml (at entry) 20 0.0002059 0.71 rs6080358 38.70 logistic AGE:SEX Ml vs no Ml (at entry) 20 0.0002925 0.71 rs6080358 38.70 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 0.0003974 0.71 rs6080358 38.70 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 20 0.0004963 0.71

O rs6085468 17.68 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 20 8.29E-05 0.66 rs6085468 17.68 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 20 0.0001225 0.66 rs6085468 17.68 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 20 0.000365 0.66 rs6089599 101.88 logistic Ml vs control (follow-up) 20 8.80E-05 0.69 rs6089599 101.88 logistic AGE:SEX Ml vs control (follow-up) 20 0.0001917 0.69 rs6093764 58.70 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 20 3.87E-06 0.40 rs6093764 58.70 logistic GE:AGE:SEX Ml vs no Ml (at entry) 20 1.47E-05 0.40 rs6093764 58.70 logistic Ml vs no Ml (at entry) 20 1.69E-05 0.40 rs6093764 58.70 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 2.06E-05 0.45 rs6093764 58.70 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 20 3.05E-05 0.40 rs6093764 58.70 logistic AGE:SEX Ml vs no Ml (at entry) 20 3.76E-05 0.40 rs6093764 58.70 logistic Ml vs no Ml (follow-up) 20 6.29E-05 0.45 rs6093764 58.70 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 20 6.48E-05 0.45 rs6093764 58.70 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 20 0.0001263 0.45 rs6093764 58.70 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 20 0.0001351 0.42 rs6093764 58.70 logistic AGEiSEX Ml vs no Ml (follow-up) 20 0.0001606 0.45 rs6093764 58.70 logistic GE:AGE:SEX Ml vs control (at entry) 20 0.0001652 0.42 rs6093764 58.70 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 20 0.0004653 0.40 rs6093764 58.70 logistic Ml vs control (at entry) 20 0.0004873 0.42

rs6095323 71.61 logistic Ml vs control (at entry) 20 0.0003349 0.72 rs6095323 71.61 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 20 0.0004132 0.72 rs6095325 71.62 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 20 0.0004649 0.73 rs6104651 28.20 logistic AGE:SEX Ml vs control (at entry) 20 0.0003514 1.34 rs6117825 19.58 logistic Ml vs no Ml (at entry) 20 0.0002035 1.37 rs6117825 19.58 logistic AGE:SEX Ml vs no Ml (at entry) 20 0.0002168 1.37 rs6117825 19.58 logistic Ml vs no Ml (follow-up) 20 0.0002965 1.35 rs6117825 19.58 logistic AGE:SEX Ml vs no Ml (follow-up) 20 0.0003184 1.35 rs6127813 86.07 logistic AGE:SEX Ml vs control (follow-up) 20 9.01 E-05 0.67 rs6127813 86.07 logistic AGE:SEX Ml vs control (at entry) 20 0.0002027 0.71 rs6127813 86.07 logistic Ml vs control (follow-up) 20 0.0002149 0.67 rs6127813 86.07 logistic GE:AGE:SEX Ml vs control (follow-up) 20 0.0004457 0.67 rs6127813 86.07 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 20 0.0004572 0.67 rs6127813 86.07 logistic Ml vs control (at entry) 20 0.0004711 0.71 rs6134772 32.96 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 0.0003432 1.28 rs6134777 32.97 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 0.0003447 1.28 rs615847 83.76 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 0.0002513 1.42

O rs615847 83.76 logistic AGEiSEX Ml vs control (at entry) 18 0.0002808 1.38 rs615847 83.76 logistic AGEiSEX Ml vs control (follow-up) 18 0.000281 1.42 rs615847 83.76 logistic GEIAGEISEX Ml vs control (follow-up) 18 0.0003345 1.42 rs615847 83.76 logistic GEiAGEiCRCLSEX Ml vs control (at entry) 18 0.0003628 1.38 rs619037 83.76 logistic GEiAGEiCRCLSEX Ml vs control (follow-up) 18 0.0002218 1.42 rs619037 83.76 logistic AGEiSEX Ml vs control (follow-up) 18 0.0002451 1.42 rs619037 83.76 logistic AGEiSEX Ml vs control (at entry) 18 0.000252 1.38 rs619037 83.76 logistic GEIAGEISEX Ml vs control (follow-up) 18 0.0002965 1.42 rs619037 83.76 logistic GEIAGEICRCLSEX Ml vs control (at entry) 18 0.0003311 1.38 rs627629 259.34 logistic GEIAGEISEX Ml vs no Ml (at entry) 1 9.55E-06 0.36 rs627629 259.34 logistic GEIAGEICRCLSEX Ml vs no Ml (at entry) 1 1.40E-05 0.36 rs627629 259.34 logistic GEiAGEiACRiSEX Ml vs no Ml (at entry) 1 1.51 E-05 0.36 rs627629 259.34 logistic Ml vs no Ml (at entry) 1 3.19E-05 0.36 rs627629 259.34 logistic AGEiSEX Ml vs no Ml (at entry) 1 4.72E-05 0.36 rs627629 259.34 logistic GEIAGEISEX Ml vs no Ml (follow-up) 1 8.29E-05 0.43 rs627629 259.34 logistic GEIAGEICRCLSEX Ml vs no Ml (follow-up) 1 0.0001192 0.43 rs627629 259.34 logistic GEIAGEIACRISEX Ml vs no Ml (follow-up) 1 0.000148 0.43 rs627629 259.34 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 1 0.000156 0.36 rs627629 259.34 logistic GEIAGEISEX Ml vs control (at entry) 1 0.0001672 0.41

rs627629 259.34 logistic Ml vs no Ml (follow-up) 1 0.0002049 0.43 rs627629 259.34 logistic GE:AGE:CRCLSEX Ml vs control (at entry) 1 0.0002403 0.41 rs627629 259.34 logistic AGE:SEX Ml vs no Ml (follow-up) 1 0.0003266 0.43 rs632248 83.77 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0001693 1.40 rs632248 83.77 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 0.0002049 1.41 rs632248 83.77 logistic AGE:SEX Ml vs control (at entry) 18 0.0002073 1.40 rs632248 83.77 logistic GE:AGE:SEX Ml vs control (follow-up) 18 0.0003365 1.41 rs632248 83.77 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0003603 1.40 rs632248 83.77 logistic AGE:SEX Ml vs control (follow-up) 18 0.0004254 1.41 rs633265 85.85 logistic GE:AGE:CRCLSEX Ml vs control (follow-up) 18 0.0001827 1.35 rs633265 85.85 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0002004 1.32 rs633265 85.85 logistic GE:AGE:SEX Ml vs control (follow-up) 18 0.0003831 1.35 rs635331 110.13 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0004547 0.85 rs642499 63.57 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 2.69E-05 1.28 rs642499 63.57 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 8.90E-05 1.19 rs642499 63.57 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 9.57E-05 1.25 rs642499 63.57 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0001828 1.24 rs6427900 214.75 logistic Ml vs no Ml (at entry) 1

O 4.53E-05 1.48 rs6427900 214.75 logistic AGE:SEX Ml vs no Ml (at entry) 1 7.02E-05 1.48 rs6427900 214.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 0.0001137 1.48 rs6427900 214.75 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 0.000128 1.48 rs6427900 214.75 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 0.0001405 1.48 rs6427900 214.75 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 0.0002001 1.54 rs6427900 214.75 logistic Ml vs no Ml (follow-up) 1 0.0002727 1.41 rs6427900 214.75 logistic AGE:SEX Ml vs no Ml (follow-up) 1 0.000436 1.41 rs6427900 214.75 logistic Ml vs control (at entry) 1 0.0004756 1.54 rs6427900 214.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.000487 1.48 rs643437 63.60 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.000392 1.19 rs6446166 70.41 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 3 8.02E-06 2.52 rs6446166 70.41 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 5.69E-05 2.52 rs6446166 70.41 logistic GE:AGE:SEX Ml vs control (at entry) 3 6.07E-05 2.52 rs6446166 70.41 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 3 7.79E-05 2.52 rs6446166 70.41 logistic AGE:SEX Ml vs control (at entry) 3 9.01 E-05 2.52 rs6446166 70.41 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 3 0.000103 2.48 rs6446166 70.41 logistic Ml vs control (at entry) 3 0.000177 2.52 rs6446605 16.66 logistic GE:AGE:ACR:SEX ^' Ml vs control (at entry) 4 8.67E-05 0.56

rs6446605 16.66 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 4 9.73E-05 0.55 rs644740 66.16 logistic AGE:SEX Ml vs control (follow-up) 11 0.0002186 0.73 rs6447494 60.12 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0004809 1.28 rs6449012 25.82 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 5.57E-05 1.42 rs6449012 25.82 logistic GE:AGE:SEX Ml vs control (follow-up) 4 6.48E-05 1.42 rs6449012 25.82 logistic AGE:SEX Ml vs control (follow-up) 4 0.0001306 1.42 rs6449012 25.82 logistic AGE:SEX Ml vs no Ml (at entry) 4 0.0001474 1.30 rs6449012 25.82 logistic Ml vs no Ml (at entry) 4 0.0001749 1.30 rs6449012 25.82 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0001921 1.30 rs6449012 25.82 logistic Ml vs control (follow-up) 4 0.0001922 1.42 rs6449012 25.82 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0001977 1.30 rs6449012 25.82 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0002373 1.28 rs6449012 25.82 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0002834 1.28 rs6449012 25.82 logistic Ml vs no Ml (follow-up) 4 0.0002836 1.28 rs6449012 25.82 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.000296 1.28 rs6449750 72.13 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 2.11 E-06 0.18 rs6449750 72.13 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 2.84E-06 0.18 rs6449750 72.13 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 3.17E-06 0.18

O rs6449750 72.13 logistic Ml vs no Ml (at entry) 5 3.37E-06 0.18 rs6449750 72.13 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 5.00E-06 0.18 rs6449750 72.13 logistic AGE:SEX Ml vs no Ml (at entry) 5 6.17E-06 0.18 rs6449750 72.13 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 1.09E-05 0.26 rs6449750 72.13 logistic Ml vs no Ml (follow-up) 5 1.36E-05 0.26 rs6449750 72.13 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 1.52E-05 0.26 rs6449750 72.13 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 1.91 E-05 0.26 rs6449750 72.13 logistic AGE:SEX Ml vs no Ml (follow-up) 5 3.07E-05 0.26 rs6449750 72.13 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 4.15E-05 0.26 rs6449750 72.13 logistic GE:AGE:SEX Ml vs control (at entry) 5 7.63E-05 0.22 rs6449750 72.13 logistic Ml vs control (at entry) 5 0.0001296 0.22 rs6449750 72.13 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 0.0001302 0.22 rs6449750 72.13 logistic AGE:SEX Ml vs control (at entry) 5 0.0001555 0.22 rs6452689 95.07 logistic AGE:SEX Ml vs control (at entry) 5 6.21 E-06 0.68 rs6452689 95.07 logistic Ml vs control (at entry) 5 1.30E-05 0.68 rs6452689 95.07 logistic GE:AGE:SEX Ml vs control (at entry) 5 6.70E-05 0.68 rs6452689 95.07 logistic AGE:SEX Ml vs control (follow-up) 5 7.47E-05 0.70 rs6452689 95.07 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 8.62E-05 0.68

rs6452689 95.07 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0001162 0.77 rs6452689 95.07 logistic Ml vs control (follow-up) 5 0.0002114 0.70 rs6452689 95.07 logistic AGE:SEX Ml vs no Ml (at entry) 5 0.0002232 0.77 rs6452689 95.07 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.000312 0.79 rs6452689 95.07 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 0.0003556 0.68 rs6452689 95.07 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0003839 0.77 rs6452689 95.07 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0003872 0.77 rs6452689 95.07 logistic Ml vs no Ml (at entry) 5 0.0004227 0.77 rs6452689 95.07 logistic GE:AGE:SEX Ml vs control (follow-up) 5 0.0004798 0.70 rs6469617 124.54 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0003678 0.78 rs6469617 124.54 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0003893 0.78 rs6469898 126.66 logistic AGE:SEX Ml vs no Ml (at entry) 8 9.77E-05 0.76 rs6469898 126.66 logistic Ml vs no Ml (at entry) 8 0.0001502 0.76 rs6469898 126.66 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0003344 0.79 rs6469898 126.66 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.000388 0.76 rs6469899 126.66 logistic AGE:SEX Ml vs no Ml (at entry) 8 5.66E-05 0.76 rs6469899 126.66 logistic Ml vs no Ml (at entry) 8 8.87E-05 0.76 rs6469899 126.66 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0002013 0.78

O rs6469899 126.66 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.00024 0.76 rs6469899 126.66 logistic Ml vs no Ml (follow-up) 8 0.0003293 0.78 rs6469899 126.66 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0003518 0.76 rs6470173 131.44 logistic AGE:SEX Ml vs control (follow-up) 8 0.0001332 1.74 rs6470173 131.44 logistic AGE:SEX Ml vs control (at entry) 8 0.0001448 1.64 rs6470173 131.44 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 8 0.0002385 1.64 rs6470173 131.44 logistic Ml vs control (at entry) 8 0.0002789 1.64 rs6470173 131.44 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.0002845 1.74 rs6470173 131.44 logistic Ml vs control (follow-up) 8 0.0003167 1.74 rs6475790 42.12 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 9 0.0003182 0.80 rs6477360 18.97 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 0.0002589 1.24 rs6477554 113.29 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 9 0.0002951 1.38 rs6478237 124.86 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 9 0.0002156 1.38 rs6484552 37.13 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 11 0.000281 0.80 rs6485030 49.00 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 11 1.30E-05 0.25 rs6485030 49.00 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 11 1.69E-05 0.25 rs6485030 49.00 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 2.72E-05 0.25 rs6485030 49.00 logistic Ml vs no Ml (at entry) 11 2.98E-05 0.25

rs6485030 49.00 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 3.48E-05 0.25 rs6485030 49.00 logistic AGE:SEX Ml vs no Ml (at entry) 11 6.15E-05 0.25 rs6485030 49.00 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 11 9.66E-05 0.33 rs6485030 49.00 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 11 0.0001089 0.33 rs6485030 49.00 logistic Ml vs no Ml (follow-up) 11 0.0001422 0.33 rs6485030 49.00 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0001672 0.33 rs6485030 49.00 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 11 0.0002135 0.33 rs6485030 49.00 logistic AGE:SEX Ml vs no Ml (follow-up) 11 0.0003538 0.33 rs6491786 86.76 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 13 0.0004284 1.83 rs649721 85.85 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0002546 1.31 rs649721 85.85 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 0.000264 1.34 rs6497456 38.65 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 16 0.000459 1.65 rs6497674 43.58 logistic Ml vs no Ml (at entry) 16 0.0003403 1.40 rs6497674 43.58 logistic Ml vs no Ml (follow-up) 16 0.0003962 1.39 rs6497674 43.58 logistic AGE:SEX Ml vs no Ml (at entry) 16 0.0004707 1.40 rs6502324 34.81 logistic GE:AGE:SEX Ml vs control (at entry) 17 0.0004485 0.64 rs6502325 34.81 logistic GE:AGE:SEX Ml vs control (at entry) 17 0.0004485 0.64 rs6505045 76.99 logistic HBP:GE:AGE:SEX Ml vs control (at entry)

O 17 0.0001004 0.78 rs6505045 76.99 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 17 0.0001492 0.80 rs6505710 41.59 logistic AGEiSEX Ml vs control (follow-up) 18 0.0002969 1.45 rs6505710 41.59 logistic Ml vs control (follow-up) 18 0.0004133 1.45 rs6505717 41.68 logistic AGE:SEX Ml vs control (follow-up) 18 0.0003251 1.43 rs6506966 59.04 logistic AGE:SEX Ml vs control (at entry) 18 0.0004779 2.15 rs6508322 51.31 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 2.53E-06 0.20 rs6508322 51.31 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 3.21 E-06 0.20 rs6508322 51.31 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 3.28E-06 0.20 rs6508322 51.31 logistic Ml vs no Ml (at entry) 18 3.78E-06 0.20 rs6508322 51.31 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 4.71 E-06 0.20 rs6508322 51.31 logistic AGE:SEX Ml vs no Ml (at entry) 18 7.24E-06 0.20 rs6508322 51.31 logistic GE:AGE:SEX Ml vs control (at entry) 18 2.61 E-05 0.23 rs6508322 51.31 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 2.94E-05 0.30 rs6508322 51.31 logistic Ml vs no Ml (follow-up) 18 3.34E-05 0.30 rs6508322 51.31 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 3.95E-05 0.30 rs6508322 51.31 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 4.28E-05 0.30 rs6508322 51.31 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 4.37E-05 0.23 rs6508322 51.31 logistic AGE:SEX Ml vs no Ml (follow-up) 18 7.94E-05 0.30

rs6508322 51.31 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 9.08E-05 0.30 rs6508322 51.31 logistic Ml vs control (at entry) 18 9.77E-05 0.23 rs6508322 51.31 logistic AGE:SEX Ml vs control (at entry) 18 0.0001465 0.23 rs6508322 51.31 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 18 0.0001808 0.23 rs6508322 51.31 logistic GE:AGE:SEX Ml vs control (follow-up) 18 0.0002933 0.32 rs6508322 51.31 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 18 0.0003172 0.32 rs6531216 40.48 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 2 0.0004153 0.77 rs6533426 114.93 logistic AGE:SEX Ml vs control (follow-up) 4 2.94E-05 0.64 rs6533426 114.93 logistic GE:AGE:SEX Ml vs control (follow-up) 4 4.05E-05 0.64 rs6533426 114.93 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 6.12E-05 0.64 rs6533426 114.93 logistic Ml vs control (follow-up) 4 0.0001026 0.64 rs6533426 114.93 logistic AGEiSEX Ml vs control (at entry) 4 0.0001655 0.68 rs6533426 114.93 logistic GE:AGE:SEX Ml vs control (at entry) 4 0.0003252 0.68 rs6533426 114.93 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.000338 0.74 rs6533426 114.93 logistic Ml vs control (at entry) 4 0.0003441 0.68 rs6545316 73.61 logistic AGEiSEX Ml vs no Ml (follow-up) 2 0.0003589 0.79 rs6545316 73.61 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 2 0.0003619 0.73 rs6545316 73.61 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0004788 0.79

O rs6545316 73.61 logistic Ml vs no Ml (follow-up) 2 0.0004803 0.79 rs6546173 83.46 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0001726 1.59 rs6546173 83.46 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0001923 1.59 rs6546173 83.46 logistic Ml vs no Ml (at entry) 2 0.0002628 1.59 rs6546173 83.46 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 2 0.0004052 1.65 rs6546173 83.46 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0004095 1.54 rs6546173 83.46 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 0.000422 1.59 rs6546173 83.46 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0004425 1.54 rs6554923 28.51 logistic GE:AGE:SEX Ml vs control (at entry) 5 6.16E-05 0.24 rs6554923 28.51 logistic Ml vs no Ml (at entry) 5 0.0001117 0.26 rs6554923 28.51 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 0.000121 0.26 rs6554923 28.51 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0001282 0.26 rs6554923 28.51 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 0.0001348 0.24 rs6554923 2B.51 logistic AGE:SEX Ml vs control (at entry) 5 0.0001364 0.24 rs6554923 28.51 logistic Ml vs control (at entry) 5 0.0001443 0.24 rs6554923 28.51 logistic AGE:SEX Ml vs no Ml (at entry) 5 0.0001631 0.26 rs6554923 28.51 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0001779 0.26 rs6554923 28.51 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0004116 0.26

rs6555784 172.87 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 5 0.000458 0.71 rs6555784 172.87 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 0.0004757 0.74 rs6577934 158.10 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 8 0.0003601 1.29 rs6582553 59.05 logistic AGEiSEX Ml vs control (at entry) 12 0.0004335 1.39 rs6588759 148.33 logistic Ml vs control (at entry) 10 3.22E-05 1.49 rs6588759 148.33 logistic AGEiSEX Ml vs control (at entry) 10 5.68E-05 1.49 rs6588759 148.33 logistic AGE:SEX Ml vs no Ml (at entry) 10 0.0001384 1.32 rs6588759 148.33 logistic Ml vs control (follow-up) 10 0.0001598 1.49 rs6588759 148.33 logistic AGE:SEX Ml vs control (follow-up) 10 0.0002031 1.49 rs6588759 148.33 logistic Ml vs no Ml (at entry) 10 0.0002278 1.32 rs6588759 148.33 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0003452 1.32 rs6588759 148.33 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 0.0003733 1.32 rs6588759 148.33 logistic GE:AGE:SEX Ml vs control (at entry) 10 0.0004617 1.49 rs6588759 148.33 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 0.0004712 1.32 rs6590248 129.14 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 11 0.0002661 0.79 rs6590248 129.14 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.000319 0.79 rs6590248 129.14 logistic AGE:SEX Ml vs no Ml (follow-up) 11 0.0004267 0.79 rs6590290 130.17 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0001132 1.19 rs6592344 89.30 logistic AGE:SEX Ml vs no Ml (follow-up) 11 9.44E-05 1.29 rs6592344 89.30 logistic AGE:SEX Ml vs control (at entry) 11 0.0001025 1.38 rs6592344 89.30 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0001662 1.28 rs6592344 89.30 logistic Ml vs control (at entry) 11 0.0001857 1.38 rs6592344 89.30 logistic Ml vs no Ml (follow-up) 11 0.0001935 1.29 rs6592344 89.30 logistic Ml vs no Ml (at entry) 11 0.0002915 1.28 rs6602164 18.84 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 0.0001799 1.42 rs6602164 18.84 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 0.000238 1.42 rs6602164 18.84 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 0.0003028 1.42 rs6602164 18.84 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0003884 1.42 rs6602164 18.84 logistic Ml vs no Ml (at entry) 10 0.0004135 1.42 rs6602164 18.84 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0004977 1.38 rs661609 83.79 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0001507 1.39 rs661609 83.79 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 0.0002414 1.38 rs661609 83.79 logistic AGE:SEX Ml vs control (at entry) 18 0.0002706 1.39 rs661609 83.79 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0003287 1.39 rs661609 83.79 logistic GE:AGE:SEX Ml vs control (follow-up) 18 0.0004144 1.38 rs661889 101.28 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 11 0.0001064 1.33

rs661889 101.28 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0002796 1.33 rs661889 101.28 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 11 0.0003186 1.33 rs661889 101.28 logistic Ml vs no Ml (at entry) 11 0.0003504 1.33 rs663978 70.09 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.0003079 1.45 rs6667872 99.40 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0002476 1.26 rs6667872 99.40 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.0004161 1.26 rs6667872 99.40 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0004749 1.24 rs6676401 244.49 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 3.35E-06 0.27 rs6676401 244.49 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 3.77E-06 0.27 rs6676401 244.49 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 4.89E-06 0.27 rs6676401 244.49 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 8.58E-06 0.27 rs6676401 244.49 logistic Ml vs no Ml (at entry) 1 8.62E-06 0.27 rs6676401 244.49 logistic AGE:SEX Ml vs no Ml (at entry) 1 1.65E-05 0.27 rs6676401 244.49 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 4.99E-05 0.36 rs6676401 244.49 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 5.87E-05 0.36 rs6676401 244.49 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 5.99E-05 0.36 rs6676401 244.49 logistic Ml vs no Ml (follow-up) 1 8.03E-05 0.36 rs6676401 244.49 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.000102 0.36

O rs6676401 244.49 logistic AGEiSEX Ml vs no Ml (follow-up) 1 0.0001761 0.36 rs6677798 99.40 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0001737 1.26 rs6677798 99.40 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0002224 1.25 rs6677798 99.40 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.0002623 1.25 rs6677802 151.26 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 1 0.0001558 0.76 rs6677802 151.26 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.0003331 0.79 rs6697738 90.08 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 1 0.0002228 1.83 rs6699979 159.59 logistic Ml vs control (follow-up) 1 0.0004287 0.63 rs6705605 234.60 logistic Ml vs no Ml (at entry) 2 0.0002202 1.43 rs6705605 234.60 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0002295 1.43 rs6705605 234.60 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0002528 1.43 rs6705605 234.60 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0002705 1.43 rs6705605 234.60 logistic Ml vs no Ml (follow-up) 2 0.0003079 1.41 rs6705605 234.60 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0003141 1.41 rs6705605 234.60 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0003622 1.41 rs6705605 234.60 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0003916 1.41 rs6718946 214.43 logistic AGE:SEX Ml vs control (at entry) 2 0.0001232 0.75 rs6718946 214.43 logistic AGE:SEX Ml vs control (follow-up) 2 0.0003256 0.76

rs6718946 214.43 logistic GE:AGE:SEX Ml vs control (at entry) 2 0.0004802 0.75 rs6720902 206.54 logistic AGE:SEX Ml vs control (at entry) 2 0.0001169 0.72 rs6720902 206.54 logistic Ml vs control (at entry) 2 0.0001214 0.72 rs6720902 206.54 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.000193 0.77 rs6720902 206.54 logistic Ml vs no Ml (at entry) 2 0.0001979 0.77 rs6720902 206.54 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0002356 0.77 rs6720902 206.54 logistic GE:AGE:ACR:.SEX Ml vs no Ml (at entry) 2 0.0002402 0.77 rs6720902 206.54 logistic Ml vs no Ml (follow-up) 2 0.0002474 0.77 rs6720902 206.54 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 0.0003348 0.77 rs6720902 206.54 logistic GE:AGE:SEX Ml vs control (at entry) 2 0.0003455 0.72 rs6720902 206.54 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0003812 0.77 rs6720902 206.54 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0003972 0.77 rs6720902 206.54 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0004193 0.72 rs6720902 206.54 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0004246 0.77 rs6720902 206.54 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0004498 0.77 rs6720902 206.54 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0004741 0.77 rs6731529 85.89 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0002277 1.30 w rs6731529 85.89 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0002541 1.30 o rs6731529 85.89 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0003437 1.30 rs6731529 85.89 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0003991 1.30 rs6732355 115.58 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0003779 1.33 rs673240 125.82 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0004096 0.58 rs6733843 94.93 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0003434 1.36 rs6733843 94.93 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.000473 1.36 rs6733843 94.93 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 0.0004768 1.36 rs6737177 50.04 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0004281 2.29 rs6751402 234.59 logistic AGE:SEX Ml vs no Ml (at entry) 2 5.28E-05 1.47 rs6751402 234.59 logistic Ml vs no Ml (at entry) 2 5.33E-05 1.47 rs6751402 234.59 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 6.91 E-05 1.47 rs6751402 234.59 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 7.64E-05 1.47 rs6751402 234.59 logistic AGEiSEX Ml vs no Ml (follow-up) 2 8.35E-05 1.45 rs6751402 234.59 logistic Ml vs no Ml (follow-up) 2 8.67E-05 1.45 rs6751402 234.59 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0001117 1.45 rs6751402 234.59 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0001247 1.45 rs6751402 234.59 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 0.0003851 1.47 rs6751526 95.01 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0004723 1.35

rs6763712 176.89 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 3.81 E-05 1.42 rs6763712 176.89 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 3 0.0001884 1.42 rs6763712 176.89 logistic Ml vs control (follow-up) 3 0.0004031 1.42 rs6766592 176.89 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 7.13E-05 1.38 rs6767992 44.53 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0003106 1.29 rs6767992 44.53 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0003356 1.29 rs6767992 44.53 logistic Ml vs no Ml (at entry) 3 0.0003448 1.29 rs6767992 44.53 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0003634 1.29 rs6774873 74.67 logistic Ml vs no Ml (at entry) 3 0.000159 0.63 rs6774873 74.67 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0002433 0.63 rs6783622 21.76 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 5.92E-05 1.46 rs6783622 21.76 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0001115 1.50 rs6783622 21.76 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0002926 1.45 rs6783622 21.76 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0003499 1.50 rs6783622 21.76 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0004137 1.50 rs6783622 21.76 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.000419 1.50 rs6783622 21.76 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 0.0004694 1.41

W rs6791790 64.17 logistic Ml vs control (at entry) 3 0.0004019 0.44 rs6801310 100.46 logistic AGE:SEX Ml vs no Ml (follow-up) 3 0.0003585 1.63 rs6814800 57.19 logistic Ml vs control (follow-up) 4 4.85E-05 1.49 rs6814800 57.19 logistic AGE:SEX Ml vs control (follow-up) 4 0.0001124 1.49 rs6814800 57.19 logistic Ml vs control (at entry) 4 0.0002321 1.39 rs6816017 114.86 logistic AGE:SEX Ml vs control (follow-up) 4 3.14E-05 0.65 rs6816017 114.86 logistic GE:AGE:SEX Ml vs control (follow-up) 4 5.35E-05 0.65 rs6816017 114.86 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 8.09E-05 0.65 rs6816017 114.86 logistic Ml vs control (follow-up) 4 0.0001162 0.65 rs6816017 114.86 logistic AGE:SEX Ml vs control (at entry) 4 0.0002831 0.69 rs6816017 114.86 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0003641 0.75 rs6818865 59.62 logistic AGE:SEX Ml vs control (follow-up) 4 0.0002504 0.67 rs6825008 32.18 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 3.71 E-05 0.50 rs6825008 32.18 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 5.70E-05 0.50 rs6825008 32.18 logistic Ml vs no Ml (at entry) 4 6.68E-05 0.50 rs6825008 32.18 logistic AGEiSEX Ml vs no Ml (at entry) 4 8.46E-05 0.50 rs6825008 32.18 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0001833 0.50 rs6825008 32.18 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0002345 0.50 rs6829190 124.18 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0001089 1.34

rs6829190 124.18 logistic GE:AGE:CRCLSEX Ml vs no Ml (follow-up) 4 0.0001522 1.33 rs6829190 124.18 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0001795 1.34 rs6829190 124.18 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0002386 1.33 rs6836327 80.38 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 4.71 E-06 0.13 rs6836327 80.38 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 6.19E-06 0.13 rs6836327 80.38 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 6.31 E-06 0.13 rs6836327 80.38 logistic Ml vs no Ml (at entry) 4 8.95E-06 0.13 rs6836327 80.38 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 1.03E-05 0.13 rs6836327 80.38 logistic AGE:SEX Ml vs no Ml (at entry) 4 1.32E-05 0.13 rs6836327 80.38 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 3.06E-05 0.25 rs6836327 80.38 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 4.49E-05 0.25 rs6836327 80.38 logistic Ml vs no Ml (follow-up) 4 4.86E-05 0.25 rs6836327 80.38 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 4.89E-05 0.25 rs6836327 80.38 logistic AGE:SEX Ml vs no Ml (follow-up) 4 8.95E-05 0.25 rs6836327 80.38 logistic GE:AGE:SEX Ml vs control (at entry) 4 0.0001042 0.16 rs6836327 80.38 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0001489 0.25 rs6836327 80.38 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 4 0.0001648 0.16 w rs6836327 80.38 logistic AGE:SEX Ml vs control (at entry) 4 0.0002521 0.16

G rs6836327 80.38 logistic Ml vs control (at entry) 4 0.0002649 0.16 rs6840609 190.02 logistic Ml vs control (at entry) 4 0.000464 0.64 rs6849903 148.70 logistic GE:AGE:SEX Ml vs control (at entry) 4 0.0003823 0.73 rs6849903 148.70 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 4 0.0003948 0.73 rs6849903 148.70 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 4 0.0004206 0.73 rs6852285 25.82 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 0.0002463 1.40 rs6852285 25.82 logistic GE:AGE:SEX Ml vs control (follow-up) 4 0.0003481 1.40 rs6852285 25.82 logistic AGE:SEX Ml vs control (follow-up) 4 0.0004094 1.40 rs6852493 153.32 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 6.43E-05 0.54 rs6852493 153.32 logistic Ml vs no Ml (at entry) 4 0.0001201 0.54 rs6852493 153.32 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0001827 0.54 rs6852493 153.32 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0002104 0.54 rs6852493 153.32 logistic AGE:SEX Ml vs no Ml (at entry) 4 0.000227 0.54 rs6852493 153.32 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.00038 0.54 rs6860898 165.39 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 6.76E-05 0.79 rs6860898 165.39 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 6.82E-05 0.79 rs6860898 165.39 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0001396 0.79 rs6860898 165.39 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0001489 0.79

rs6860898 165.39 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0001507 0.79 rs6860898 165.39 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0001521 0.79 rs6860898 165.39 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.000412 0.79 rs6860898 165.39 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.0004261 0.79 rs687328 99.49 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0003512 0.81 rs6880404 165.39 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.0002528 0.80 rs6880404 165.39 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0002978 0.80 rs6880404 165.39 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0004225 0.81 rs6880404 165.39 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0004301 0.81 rs6880404 165.39 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0004765 0.80 rs6883415 164.11 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 5 0.000177 1.27 rs688933 66.15 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 0.0001601 1.48 rs688933 66.15 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0003433 1.48 rs6893843 164.11 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 5 0.0004018 1.20 rs6902835 103.42 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0003922 0.77 rs6902835 103.42 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 0.0003998 0.77 rs6905476 40.41 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0003145 2.67 w rs6905476 40.41 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0003309 2.67

C rs6905476 40.41 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0003842 2.67 rs6905476 40.41 logistic Ml vs no Ml (follow-up) 6 0.0004351 2.67 rs6905476 40.41 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0004475 2.67 rs6906788 136.84 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 6 3.37E-05 0.56 rs6906788 136.84 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 4.87E-05 0.59 rs6906788 136.84 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0004663 0.61 rs6909578 115.97 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 6.34E-07 0.15 rs6909578 115.97 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 8.64E-07 0.15 rs6909578 115.97 logistic Ml vs no Ml (at entry) 6 9.59E-07 0.15 rs6909578 115.97 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 9.98E-07 0.15 rs6909578 115.97 logistic AGE:SEX Ml vs no Ml (at entry) 6 1.86E-06 0.15 rs6909578 115.97 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 2.25E-06 0.15 rs6909578 115.97 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 4.41 E-06 0.25 rs6909578 115.97 logistic Ml vs no Ml (follow-up) 6 5.04E-06 0.25 rs6909578 115.97 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 6.41 E-06 0.25 rs6909578 115.97 logistic GE:AGE:SEX Ml vs control (at entry) 6 6.62E-06 0.17 rs6909578 115.97 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 8.82E-06 0.25 rs6909578 115.97 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 6 1.22E-05 0.17

rs6909578 115.97 logistic AGEiSEX Ml vs no Ml (follow-up) 6 1.29E-05 0.25 rs6909578 115.97 logistic Ml vs control (at entry) 6 2.21 E-05 0.17 rs6909578 115.97 logistic AGE:SEX Ml vs control (at entry) 6 2.22E-05 0.17 rs6909578 115.97 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 3.23E-05 0:25 rs6909578 115.97 logistic GE:AGE:SEX Ml vs control (follow-up) 6 6.02E-05 0.26 rs6909578 115.97 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 6 0.0001214 0.26 rs6909578 115.97 logistic AGEiSEX Ml vs control (follow-up) 6 0.0001381 0.26 rs6909578 115.97 logistic Ml vs control (follow-up) 6 0.0001396 0.26 rs6909578 115.97 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.000219 0.17 rs6916232 103.38 logistic Ml vs no Ml (at entry) 6 9.49E-06 0.66 rs6916232 103.38 logistic AGEiSEX Ml vs no Ml (at entry) 6 1.51 E-05 0.66 rs6916232 103.38 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 2.95E-05 0.66 rs6916232 103.38 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 3.36E-05 0.66 rs6916232 103.38 logistic Ml vs no Ml (follow-up) 6 3.56E-05 0.68 rs6916232 103.38 logistic AGE:SEX Ml vs no Ml (follow-up) 6 6.01 E-05 0.68 rs6916232 103.38 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001017 0.68 rs6916232 103.38 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0001075 0.66

W rs6916232 103.38 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0001164 0.68 rs6916232 103.38 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0001406 0.66 rs6916232 103.38 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0001923 0.68 rs6916232 103.38 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0003843 0.68 rs6917097 23.88 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 5.68E-05 0.76 rs6917097 23.88 logistic Ml vs no Mi (at entry) 6 0.0001272 0.76 rs6917097 23.88 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0001408 0.76 rs6917097 23.88 logistic AGE:SEX Ml vs no Ml (at entry) 6 0.0001514 0.76 rs6917097 23.88 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0002035 0.76 rs6917097 23.88 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0002706 0.76 rs6923212 103.42 logistic Ml vs no Ml (at entry) 6 7.07E-06 0.65 rs6923212 103.42 logistic AGE:SEX Ml vs no Ml (at entry) 6 1.12E-05 0.65 rs6923212 103.42 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 2.36E-05 0.65 rs6923212 103.42 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 2.64E-05 0.65 rs6923212 103.42 logistic Ml vs no Ml (follow-up) 6 2.80E-05 0.68 rs6923212 103.42 logistic AGEiSEX Ml vs no Ml (follow-up) . 6 4.71 E-05 0.68 rs6923212 103.42 logistic GEIAGEISEX Ml vs no Ml (follow-up) 6 8.45E-05 0.68 rs6923212 103.42 logistic GEiAGEiCRCLiSEX Ml vs no Ml (follow-up) 6 9.50E-05 0.68 rs6923212 103.42 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 6 0.0001136 0.65

rs6923212 103.42 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0001144 0.65 rs6923212 103.42 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0001607 0.68 rs6923212 103.42 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0004124 0.68 rs6924957 103.33 logistic Ml vs no Ml (at entry) 6 0.0001621 0.73 rs6924957 103.33 logistic Ml vs no Ml (follow-up) 6 0.0002009 0.74 rs6924957 103.33 logistic AGE:SEX Ml vs no Ml (at entry) 6 0.0003391 0.73 rs6924957 103.33 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0003636 0.73 rs6924957 103.33 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 0.0004109 0.73 rs6924957 103.33 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0004711 0.74 rs6924957 103.33 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.000488 0.74 rs6925312 93.12 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 6 0.0004966 0.79 rs693253 127.92 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 11 1.00E-06 0.65 rs693253 127.92 logistic Ml vs control (at entry) 11 1.51 E-06 0.65 rs693253 127.92 logistic GE:AGE:SEX Ml vs control (at entry) 11 1.53E-06 0.65 rs693253 127.92 logistic AGEiSEX Ml vs control (at entry) 11 2.05E-06 0.65 rs693253 127.92 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 5.28E-06 0.65 rs693253 127.92 logistic AGEiSEX Ml vs no Ml (at entry) 11 2.21 E-05 0.73 _w rs693253 127.92 logistic Ml vs no Ml (at entry) 11 2.38E-05 0.73 u, rs693253 127.92 logistic GEiAGEiCRCLiSEX Ml vs no Ml (at entry) 11 2.48E-05 0.73 rs693253 127.92 logistic GEIAGEISEX Ml vs no Ml (at entry) 11 2.61 E-05 0.73 rs693253 127.92 logistic GEiAGEiCRCLSEX Ml vs control (follow-up) 11 4.13E-05 0.67 rs693253 127.92 logistic Ml vs control (follow-up) 11 4.67E-05 0.67 rs693253 127.92 logistic GEiAGEiACRiSEX Ml vs no Ml (at entry) 11 5.25E-05 0.73 rs693253 127.92 logistic AGEiSEX Ml vs no Ml (follow-up) 11 5.31 E-05 0.75 rs693253 127.92 logistic Ml vs no Ml (follow-up) 11 5.77E-05 0.75 rs693253 127.92 logistic GEIAGEICRCLISEX Ml vs no Ml (follow-up) 11 5.92E-05 0.75 rs693253 127.92 logistic GEIAGEISEX Ml vs no Ml (follow-up) 11 6.15E-05 0.75 rs693253 127.92 logistic GEIAGEISEX Ml vs control (follow-up) 11 6.73E-05 0.67 rs693253 127.92 logistic AGEISEX Ml vs control (follow-up) 11 7.08E-05 0.67 rs693253 127.92 logistic GEIAGEIACRISEX Ml vs control (follow-up) 11 8.66E-05 0.67 rs693253 127.92 logistic GEIAGEIACRISEX Ml vs no Ml (follow-up) 11 0.0001474 0.75 rs6953625 148.47 logistic GEIAGEIACRISEX Ml vs control (follow-up) 7 0.0002875 1.34 rs6955265 151.08 logistic AGEISEX Ml vs control (at entry) 7 6.80E-05 0.71 rs6955265 151.08 logistic Ml vs control (at entry) 7 0.0001056 0.71 rs6955265 151.08 logistic AGEiSEX Ml vs control (follow-up) 7 0.000134 0.71 rs6955265 151.08 logistic GEIAGEICRCLISEX Ml vs control (at entry) 7 0.0001464 0.71

rs6955265 151.08 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0002471 0.71 rs6955265 151.08 logistic Ml vs control (follow-up) 7 0.0002574 0.71 rs6955265 151.08 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 0.0002977 0.71 rs6955265 151.08 logistic GE:AGE:SEX Ml vs control (follow-up) 7 0.0004517 0.71 rs6955954 75.93 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 7 0.0003866 1.84 rs6956284 151.06 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 7 6.20E-05 0.70 rs6956284 151.06 logistic AGEiSEX Ml vs control (at entry) 7 8.45E-05 0.70 rs6956284 151.06 logistic Ml vs control (at entry) 7 8.72E-05 0.70 rs6956284 151.06 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 0.0002542 0.70 rs6956284 151.06 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0003191 0.70 rs6956284 151.06 logistic Ml vs no Ml (at entry) 7 0.0003352 0.77 rs6956284 151.06 logistic AGE:SEX Ml vs no Ml (at entry) 0.000365 0.77 rs6956675 76.73 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 7 0.0004678 0.82 rs6975680 62.59 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 7 9.17E-05 1.47 rs6975680 62.59 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 0.0001004 1.34 rs6975680 62.59 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 0.000113 1.47 rs6975680 62.59 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 7 0.0001221 1.49 _w rs6975680 62.59 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0001686 1.47

S rs6975680 62.59 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 0.0001965 1.34 rs6975680 62.59 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 0.0002165 1.34 rs6975680 62.59 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 0.0002727 1.49 rs6975680 62.59 logistic GE:AGE:SEX WII vs control (follow-up) 7 0.0004199 1.49 rs6975680 62.59 logistic Ml vs no Ml (follow-up) 7 0.0004486 1.34 rs6975798 129.82 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 7 4.37E-05 1.47 rs6975798 129.82 logistic AGE:SEX Ml vs control (follow-up) 7 8.50E-05 1.47 rs6975798 129.82 logistic GE:AGE:SEX Ml vs control (follow-up) 7 0.0001522 1.47 rs6975798 129.82 logistic Ml vs control (follow-up) 7 0.00016 1.47 rs6975798 129.82 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 7 0.0002262 1.47 rs6980687 106.18 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 0.0004723 0.74 rs6981660 60.15 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 8 0.0004239 0.89 rs6982260 64.46 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0003023 1.24 rs6996243 109.71 logistic AGE:SEX Ml vs control (at entry) 8 0.0004314 1.37 rs6998702 94.25 logistic AGE:SEX Ml vs no Ml (at entry) 8 9.72E-05 0.70 rs6998702 94.25 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0001061 0.70 rs6998702 94.25 logistic Ml vs no Ml (at entry) 8 0.0001095 0.70 rs6998702 94.25 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0004538 0.70

rs6998702 94.25 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0004669 0.73 rs7004124 124.56 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 0.0001935 0.73 rs7004124 124.56 logistic GE:AGE:SEX Ml vs control (at entry) 8 0.000226 0.73 rs7004124 124.56 logistic AGE:SEX Ml vs control (at entry) 8 0.0003983 0.73 rs7004124 124.56 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.000416 0.78 rs7004124 124.56 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0004226 0.78 rs7005284 64.46 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0002258 1.25 rs700547 173.01 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0003202 2.39 rs700547 173.01 logistic GE:AGE:SEX Ml vs control (at entry) 2 0.0004418 2.39 rs7006704 64.46 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.00019 1.24 rs7007223 47.79 logistic Ml vs control (follow-up) 8 7.86E-05 1.53 rs7007223 47.79 logistic Ml vs no Ml (follow-up) 8 0.0001122 1.34 rs7007223 47.79 logistic AGE:SEX Ml vs control (follow-up) 8 0.000144 1.53 rs7007223 47.79 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.000159 1.34 rs7007223 47.79 logistic Ml vs control (at entry) 8 0.0002694 1.43 rs7007223 47.79 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 0.0003809 1.34 rs7007223 47.79 logistic AGEiSEX Ml vs control (at entry) 8 0.0003926 1.43 w rs7007223 47.79 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 8 0.0004253 1.34

^ rs7007223 47.79 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0004947 1.34 rs7011618 105.49 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0004681 1.26 rs7011618 105.49 logistic AGE:SEX Ml vs no Ml (at entry) 8 0.0004788 1.27 rs7013158 155.88 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0004343 1.34 rs7013903 66.60 logistic Ml vs control (follow-up) 8 0.000455 0.67 rs7014818 73.60 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0002156 1.30 rs7017087 94.25 logistic AGEiSEX Ml vs no Ml (at entry) 8 8.70E-05 0.69 rs7017087 94.25 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 8 9.12E-05 0.69 rs7017087 94.25 logistic Ml vs no Ml (at entry) 8 9.28E-05 0.69 rs7017087 94.25 logistic GEIAGEISEX Ml vs no Ml (at entry) 8 0.000401 0.69 rs7017087 94.25 logistic AGEISEX Ml vs no Ml (follow-up) 8 0.0004308 0.73 rs7017087 94.25 logistic HBPIGEIAGEISEX Ml vs no Ml (follow-up) 8 0.0004535 0.73 rs7017087 94.25 logistic Ml vs no Ml (follow-up) 8 0.0004714 0.73 rs7017143 64.46 logistic HBPIGEIAGEISEX Ml vs no Ml (follow-up) 8 0.0002605 1.24 rs7019068 117.21 logistic GEiAGEiCRCLiSEX Ml vs control (at entry) 9 0.0004802 0.73 rs7021834 66.22 logistic GEiAGEiACRiSEX Ml vs control (follow-up) 9 6.26E-05 1.56 rs7021834 66.22 logistic GEIAGEICRCLISEX Ml vs control (follow-up) 9 9.99E-05 1.56 rs7021834 66.22 logistic HBPIGEIAGEISEX Ml vs control (follow-up) 9 0.0001272 1.56

rs7021834 66.22 logistic AGE:SEX Ml vs control (follow-up) 9 0.0001304 1.56 rs7021834 66.22 logistic Ml vs control (follow-up) 9 0.0002731 1.56 rs7021834 66.22 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0003144 1.56 rs7024250 8.33 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 9 0.0001743 1.57 rs7024250 8.33 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 0.0001795 1.57 rs7024250 8.33 logistic AGE:SEX Ml vs no Ml (follow-up) 9 0.0002259 1.57 rs7024250 8.33 logistic Ml vs no Ml (follow-up) 9 0.0002457 1.57 rs7024250 8.33 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 9 0.0003475 1.57 rs7024250 8.33 logistic Ml vs control (follow-up) 9 0.0004486 1.98 rs7027322 27.92 logistic GE:AGE:SEX Ml vs control (follow-up) 9 7.21 E-05 0.67 rs7027322 27.92 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 7.25E-05 0.67 rs7027322 27.92 logistic GE:AGE:SEX Ml vs control (at entry) 9 0.0001086 0.71 rs7027322 27.92 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 9 0.0001216 0.71 rs7027322 27.92 logistic Ml vs control (follow-up) 9 0.0001762 0.67 rs7027322 27.92 logistic AGE:SEX Ml vs control (follow-up) 9 0.0001798 0.67 rs7027322 27.92 logistic AGE:SEX Ml vs control (at entry) 9 0.0003677 0.71 rs7027322 27.92 logistic Ml vs control (at entry) 9 0.0004207 0.71 w rs706551 76.94 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 2 0.0003533 1.36

Se rs7067701 148.33 logistic Ml vs control (at entry) 10 3.37E-05 1.50 rs7067701 148.33 logistic AGE:SEX Ml vs control (at entry) 10 6.12E-05 1.50 rs7067701 148.33 logistic AGE:SEX Ml vs no Ml (at entry) 10 0.0001691 1.31 rs7067701 148.33 logistic Ml vs no Ml (at entry) 10 0.0002718 1.31 rs7067701 148.33 logistic Ml vs control (follow-up) 10 0.0004489 1.46 rs7067738 35.46 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0002591 0.70 rs7076566 103.72 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 0.0004777 1.15 rs7076691 103.72 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 0.0003805 1.16 rs708475 156.57 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0002353 1.41 rs708475 156.57 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0002851 1.41 rs708475 156.57 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0003453 1.41 rs708475 156.57 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0003476 1.41 rs708475 156.57 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0003807 1.41 rs708475 156.57 logistic Ml vs no Ml (at entry) 3 0.000431 1.41 rs7089460 42.41 logistic AGE:SEX Ml vs control (at entry) 10 0.0004175 1.33 rs7090837 49.51 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0002353 1.16 rs7091247 81.90 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0004743 1.20 rs7107881 87.74 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 11 0.0001745 0.72

rs7107881 87.74 logistic GE:AGE:SEX Ml vs control (follow-up) 11 0.0002527 0.72 rs7107881 87.74 logistic Ml vs control (follow-up) 11 0.0003627 0.72 rs7116628 130.14 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.000268 1.17 rs7117687 89.30 logistic AGE:SEX Ml vs control (at entry) 11 0.0001099 1.39 rs7117687 89.30 logistic AGE:SEX Ml vs no Ml (follow-up) 11 0.000183 1.28 rs7117687 89.30 logistic Ml vs control (at entry) 11 0.0001984 1.39 rs7117687 89.30 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0002034 1.29 rs7117687 89.30 logistic Ml vs no Ml (at entry) 11 0.0003349 1.29 rs7117687 89.30 logistic Ml vs no Ml (follow-up) 11 0.0003396 1.28 rs7117839 89.30 logistic AGE:SEX Ml vs no Ml (follow-up) 11 5.35E-05 1.30 rs7117839 89.30 logistic AGE:SEX Ml vs control (at entry) 11 5.72E-05 1.40 rs7117839 89.30 logistic AGEiSEX Ml vs no Ml (at entry) 11 7.18E-05 1.31 rs7117839 89.30 logistic Ml vs control (at entry) 11 0.0001016 1.40 rs7117839 89.30 logistic Ml vs no Ml (follow-up) 11 0.0001112 1.30 rs7117839 89.30 logistic Ml vs no Ml (at entry) 11 0.0001294 1.31 rs7117839 89.30 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0003689 1.30 rs7126236 133.93 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 11 7.52E-05 1.76 _w rs7130480 127.86 logistic GE:AGE:SEX Ml vs control (at entry) 11 0.0002457 0.71

S rs7130480 127.86 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 11 0.0003232 0.71 rs7135085 153.27 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0004114 0.69 rs7136397 59.40 logistic AGE:SEX Ml vs control (follow-up) 12 0.0001026 1.43 rs7136397 59.40 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 0.0001747 1.43 rs7136397 59.40 logistic GE:AGE:SEX Ml vs control (follow-up) 12 0.0001894 1.43 rs7136397 59.40 logistic Ml vs control (follow-up) 12 0.000401 1.43 rs713978 52.92 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 22 0.0002808 0.76 rs713978 52.92 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 22 0.0004777 0.76 rs7148456 133.45 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 14 0.0001421 1.36 rs714875 33.13 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 9 0.0002893 2.35 rs7152210 90.47 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 14 0.0004524 0.89 rs7163643 74.91 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 15 0.0002118 1.21 rs7165874 53.21 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 15 0.0003742 1.30 rs7168308 85.04 logistic AGE:SEX Ml vs no Ml (at entry) 15 0.0003314 1.27 rs7169478 37.16 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 15 0.0003841 1.43 rs7169478 37.16 logistic Ml vs no Ml (at entry) 15 0.0004816 1.43 rs7175099 107.58 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 15 0.0004554 0.78 rs7175099 107.58 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 15 0.0004664 0.78

rs7179293 37.14 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 15 0.0001068 1.33 rs7179293 37.14 logistic GE:AGE:SEX Ml vs control (at entry) 15 0.000337 1.33 rs7185053 27.31 logistic AGE:SEX Ml vs control (at entry) 16 0.0004554 0.67 rs7190907 104.72 logistic AGE:SEX Ml vs control (follow-up) 16 0.0004466 0.70 rs7191101 104.65 logistic AGE:SEX Ml vs control (at entry) 16 0.0002659 1.46 rs7191101 104.65 logistic Ml vs control (at entry) 16 0.0003955 1.46 rs7191770 11.59 logistic GE:AGE:SEX Ml vs no Ml (at entry) 16 8.35E-07 0.11 rs7191770 11.59 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 16 1.08E-06 0.11 rs7191770 11.59 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 16 1.08E-06 0.11 rs7191770 11.59 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 16 1.10E-06 0.11 rs7191770 11.59 logistic Ml vs no Ml (at entry) 16 1.22E-06 0.11 rs7191770 11.59 logistic AGE:SEX Ml vs no Ml (at entry) 16 2.15E-06 0.11 rs7191770 11.59 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 16 2.93E-06 0.21 rs7191770 11.59 logistic Ml vs no Ml (follow-up) 16 3.25E-06 0.21 rs7191770 11.59 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 16 4.12E-06 0.21 rs7191770 11.59 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 16 4.73E-06 0.21 rs7191770 11.59 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 16 7.79E-06 0.21 rs7191770 11.59 logistic AGE:SEX Ml vs no Ml (follow-up) 16 8.04E-06 0.21

O rs7191770 11.59 logistic GE:AGE:SEX Ml vs control (at entry) 16 5.15E-05 0.15 rs7191770 11.59 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 16 7.79E-05 0.15 rs7191770 11.59 logistic AGE:SEX Ml vs control (at entry) 16 9.47E-05 0.15 rs7191770 11.59 logistic Ml vs control (at entry) 16 0.000109 0.15 rs7192512 104.71 logistic AGE:SEX Ml vs control (follow-up) 16 0.0002912 0.71 rs7195806 124.68 logistic Ml vs control (at entry) 16 0.0002444 0.72 rs7195806 124.68 logistic AGEiSEX Ml vs control (at entry) 16 0.0002794 0.72 rs7199114 8.97 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 16 0.0003986 0.69 rs7199114 8.97 logistic GE:AGE:SEX Ml vs control (follow-up) 16 0.0004601 0.69 rs720727 71.60 logistic Ml vs control (at entry) 20 0.0004967 0.73 rs7215839 45.56 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 17 0.0002118 0.80 rs7220146 81.57 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 17 0.0004247 1.27 rs7228559 45.71 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0004431 1.23 rs7236575 69.13 logistic Ml vs control (at entry) 18 0.0004108 1.59 rs7236715 41.59 logistic AGE:SEX Ml vs control (follow-up) 18 0.0002006 1.47 rs7236715 41.59 logistic Ml vs control (follow-up) 18 0.000289 1.47 rs7238329 107.91 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0002455 0.12 rs7238329 107.91 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0002824 0.12

rs7238329 107.91 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0002907 0.12 rs7238329 107.91 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0003399 0.20 rs7238329 107.91 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0003431 0.12 rs7238329 107.91 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 0.0004069 0.20 rs7238329 107.91 logistic Ml vs no Ml (at entry) 18 0.0004176 0.12 rs7238329 107.91 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 0.000455 0.20 rs7240443 72.72 logistic Ml vs control (at entry) 18 8.86E-05 0.71 rs7240443 72.72 logistic AGE:SEX Ml vs control (at entry) 18 0.0001139 0.71 rs7240443 72.72 logistic AGE:SEX Ml vs control (follow-up) 18 0.0003686 0.71 rs7240443 72.72 logistic Ml vs control (follow-up) 18 0.0003806 0.71 rs7241635 62.07 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.000162 0.80 rs7241635 62.07 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0003628 0.80 rs7253956 56.14 logistic AGE:SEX Ml vs control (at entry) 19 0.0001752 0.72 rs7253956 56.14 logistic Ml vs control (at entry) 19 0.0002222 0.72 rs7268711 54.12 logistic GE:AGE:SEX Ml vs control (at entry) 20 0.0001396 0.67 rs7268711 54.12 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 20 0.0001802 0.67 rs7268711 54.12 logistic Ml vs control (at entry) 20 0.0004394 0.67 _w rs7272436 81.54 logistic GE:AGE:SEX Ml vs control (follow-up) 20 0.0003443 0.32

£ rs7272436 81.54 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 20 0.0004941 0.32 rs728047 130.11 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 11 0.0002716 0.86 rs7281608 17.93 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 21 0.0002258 1.41 rs7281608 17.93 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 21 0.0004199 1.43 rs729438 133.55 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 14 6.64E-05 1.40 rs729438 133.55 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 14 0.0001129 1.40 rs7294776 110.29 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 12 0.0002894 0.58 rs7294776 110.29 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 0.0003123 0.59 rs7294776 110.29 logistic AGE:SEX Ml vs no Ml (at entry) 12 0.0003476 0.58 rs7294776 110.29 logistic GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0003701 0.58 rs7294776 110.29 logistic AGE:SEX Ml vs no Ml (follow-up) 12 0.0003712 0.59 rs7294776 110.29 logistic Ml vs no Ml (at entry) 12 0.000377 0.58 rs7294776 110.29 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 0.0003901 0.59 rs7294776 110.29 logistic Ml vs no Ml (follow-up) 12 0.0004121 0.59 rs7294776 110.29 logistic Ml vs control (at entry) 12 0.0004678 0.54 rs729784 118.60 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 4.38E-05 0.76 rs729784 118.60 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.0001708 0.79 rs7301998 59.40 logistic AGE:SEX Ml vs control (follow-up) 12 0.0001026 1.43

rs7301998 59.40 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 0.0001747 1.43 rs7301998 59.40 logistic GE:AGE:SEX Ml vs control (follow-up) 12 0.0001894 1.43 rs7301998 59.40 logistic Ml vs control (follow-up) 12 0.000401 1.43 rs7302315 93.67 logistic AGE:SEX Ml vs control (at entry) 12 0.0001243 0.70 rs7302315 93.67 logistic Ml vs control (at entry) 12 0.0001334 0.70 rs7302315 93.67 logistic Ml vs control (follow-up) 12 0.0002401 0.69 rs7302315 93.67 logistic AGE:SEX Ml vs control (follow-up) 12 0.000275 0.69 rs7302914 17.08 logistic AGE:SEX Ml vs control (follow-up) 12 1.59E-05 0.42 rs7302914 17.08 logistic GE:AGE:SEX Ml vs control (follow-up) 12 1.82E-05 0.42 rs7302914 17.08 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 2.03E-05 0.42 rs7302914 17.08 logistic Ml vs control (follow-up) 12 3.48E-05 0.42 rs7302914 17.08 logistic GE:AGE:SEX Ml vs control (at entry) 12 6.91 E-05 0.46 rs7302914 17.08 logistic AGE:SEX Ml vs control (at entry) 12 7.23E-05 0.46 rs7302914 17.08 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 8.59E-05 0.46 rs7302914 17.08 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0001322 0.42 rs7302914 17.08 logistic Ml vs control (at entry) 12 0.0001463 0.46 rs730354 59.30 logistic AGEiSEX Ml vs no Ml (follow-up) 5 2.80E-05 1.34 rs730354 59.30 logistic Ml vs no Ml (follow-up) 5 4.60E-05 1.34

K) rs730354 59.30 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 8.63E-05 1.34 rs730354 59.30 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.000131 1.34 rs730354 59.30 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 0.0002053 1.34 rs730354 59.30 logistic AGEiSEX Ml vs no Ml (at entry) 5 0.0002295 ^• 1.30 rs730354 59.30 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0002789 1.34 rs730354 59.30 logistic Ml vs no Ml (at entry) 5 0.0003341 1.30 rs730354 59.30 logistic AGEiSEX Ml vs control (at entry) 5 0.0003724 1.36 rs730354 59.30 logistic AGEiSEX Ml vs control (follow-up) 5 0.0004833 1.38 rs7304649 38.35 logistic Ml vs no Ml (at entry) 12 8.81 E-08 0.32 rs7304649 38.35 logistic GEIAGEISEX Ml vs no Ml (at entry) 12 9.21 E-08 0.32 rs7304649 38.35 logistic AGEISEX Ml vs no Ml (at entry) 12 1.92E-07 0.32 rs7304649 38.35 logistic GEiAGEiCRCLiSEX Ml vs no Ml (at entry) 12 1.93E-07 0.32 rs7304649 38.35 logistic GEiAGEiACRiSEX Ml vs no Ml (at entry) 12 2.44E-07 0.32 rs7304649 38.35 logistic GEIAGEISEX Ml vs control (at entry) 12 4.20E-07 0.31 rs7304649 38.35 logistic Ml vs control (at entry) 12 6.85E-07 0.31 rs7304649 38.35 logistic AGEISEX Ml vs control (at entry) 12 7.84E-07 0.31 rs7304649 38.35 logistic GEIAGEICRCLISEX Ml vs control (at entry) 12 8.13E-07 0.31 rs7304649 38.35 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 12 8.54E-07 0.32

rs7304649 38.35 logistic Ml vs no Ml (follow-up) 12 2.57E-06 0.41 rs7304649 38.35 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 12 3.41 E-06 0.41 rs7304649 38.35 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 4.93E-06 0.41 rs7304649 38.35 logistic AGE:SEX Ml vs no Ml (follow-up) 12 6.41 E-06 0.41 rs7304649 38.35 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 12 6.94E-06 0.41 rs7304649 38.35 logistic Ml vs control (follow-up) 12 3.00E-05 0.38 rs7304649 38.35 logistic GE:AGE:SEX Ml vs control (follow-up) 12 3.67E-05 0.38 rs7304649 38.35 logistic AGEiSEX Ml vs control (follow-up) 12 4.21 E-05 0.38 rs7304649 38.35 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 12 4.42E-05 0.41 rs7304649 38.35 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 7.24E-05 0.38 rs7304649 38.35 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 12 0.0002873 0.31 rs730561 98.74 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 8 1.62E-05 0.14 rs730561 98.74 logistic Ml vs no Ml (follow-up) 8 2.04E-05 0.14 rs730561 98.74 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 8 2.08E-05 0.14 rs730561 98.74 logistic GE:AGE:ACR:SEX Mi vs no Ml (follow-up) 8 2.42E-05 0.14 rs730561 98.74 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 2.60E-05 0.09 rs730561 98.74 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 3.13E-05 0.09 rs730561 98.74 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 3.29E-05 0.09 rs730561 98.74 logistic AGE:SEX Ml vs no Ml (follow-up) 8 3.51 E-05 0.14 rs730561 98.74 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 8 3.54E-05 0.14 rs730561 98.74 logistic Ml vs no Ml (at entry) 8 3.59E-05 0.09 rs730561 98.74 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 4.04E-05 0.09 rs730561 98.74 logistic GE:AGE:SEX Ml vs control (at entry) 8 4.85E-05 0.09 rs730561 98.74 logistic GE:AGE:SEX Ml vs control (follow-up) 8 5.06E-05 0.15 rs730561 98.74 logistic AGE:SEX Ml vs no Ml (at entry) 8 5.09E-05 0.09 rs730561 98.74 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 7.91 E-05 0.09 rs730561 98.74 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 8 8.24E-05 0.15 rs730561 98.74 logistic AGE:SEX Ml vs control (at entry) 8 0.0001045 0.09 rs730561 98.74 logistic AGE:SEX Ml vs control (follow-up) 8 0.0001063 0.15 rs730561 98.74 logistic Ml vs control (at entry) 8 0.0001089 0.09 rs730561 98.74 logistic Ml vs control (follow-up) 8 0.0001299 0.15 rs730561 98.74 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.0002901 0.15 rs730561 98.74 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 8 0.0004638 0.09 rs7311488 118.56 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 6.88E-05 0.78 rs7311488 118.56 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.000252 0.80 rs7312492 14.71 logistic AGE:SEX Ml vs control (follow-up) 12 0.0003282 0.72

rs7312492 14.71 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 0.000392 0.72 rs7312492 14.71 logistic GE:AGE:SEX Ml vs control (follow-up) 12 0.0004198 0.72 rs7312492 14.71 logistic Ml vs control (follow-up) 12 0.0004985 0.72 rs7313816 36.61 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 12 0.0001349 1.40 rs7313816 36.61 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0003364 1.40 rs7313816 36.61 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 12 0.0003635 1.38 rs7317235 43.10 logistic AGE:SEX Ml vs control (at entry) 13 6.43E-05 0.71 rs7317235 43.10 logistic Ml vs control (at entry) 13 7.24E-05 0.71 rs7317235 43.10 logistic Ml vs control (follow-up) 13 0.0001018 0.69 rs7317235 43.10 logistic AGE:SEX Ml vs control (follow-up) 13 0.0001301 0.69 rs7327778 86.73 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 13 0.0003022 1.34 rs7331598 60.08 logistic AGE:SEX Ml vs control (follow-up) 13 0.0003941 0.34 rs7331598 60.08 logistic GE:AGE:SEX Ml vs control (follow-up) 13 0.0004859 0.34 rs733508 178.93 logistic AGE:SEX Ml vs control (follow-up) 3 0.0001214 0.69 rs733508 178.93 logistic AGE:SEX Ml vs control (at entry) 3 0.000127 0.72 rs733508 178.93 logistic Ml vs control (follow-up) 3 0.000159 0.69 rs733508 178.93 logistic GE:AGE:SEX Ml vs control (at entry) 3 0.0001633 0.72 _w rs733508 178.93 logistic Ml vs control (at entry) 3 0.000188 0.72

£ rs733508 178.93 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 3 0.0002567 0.72 rs733508 178.93 logistic GE:AGE:SEX Ml vs control (follow-up) 3 0.0002846 0.69 rs733508 178.93 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 3 0.0003877 0.69 rs7338402 72.61 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 0.0001304 1.45 rs7338402 72.61 logistic GE:AGE:SEX Ml vs no Ml (at entry) 13 0.000176 1.45 rs7338402 72.61 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 13 0.0001828 1.45 rs7338402 72.61 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 13 0.0003484 1.41 rs735392 106.38 logistic AGE:SEX Ml vs control (at entry) 7 0.0001345 0.71 rs735392 106.38 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 0.0002957 0.71 rs735392 106.38 logistic Ml vs control (at entry) 7 0.0003896 0.71 rs736239 57.43 logistic AGE:SEX Ml vs control (follow-up) 19 0.0003497 0.72 rs7373237 219.98 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 6.73E-05 1.30 rs7373237 219.98 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0001334 1.27 rs7373237 219.98 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0002075 1.30 rs7373237 219.98 logistic Ml vs no Ml (at entry) 3 0.0002077 1.30 rs7373237 219.98 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0002192 1.30 rs7373237 219.98 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 0.0003956 1.27 rs7373237 219.98 logistic Ml vs no Ml (follow-up) 3 0.0004097 1.27

rs7373237 219.98 logistic AGE:SEX Ml vs no Ml (follow-up) 3 0.0004375 1.27 rs7373237 219.98 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0004859 1.30 rs7414246 99.50 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0001648 0.84 rs7414246 99.50 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0002193 0.85 rs7421353 48.06 logistic Ml vs control (at entry) 2 1.62E-05 0.69 rs7421353 48.06 logistic AGE:SEX Ml vs control (at entry) 2 2.09E-05 0.69 rs7421353 48.06 logistic AGE:SEX Ml vs no Ml (at entry) 2 6.38E-05 0.75 rs7421353 48.06 logistic Ml vs no Ml (at entry) 2 7.04E-05 0.75 rs7421353 48.06 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 7.35E-05 0.76 rs7421353 48.06 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 7.61 E-05 0.75 rs7421353 48.06 logistic AGE:SEX Ml vs no Ml (follow-up) 2 9.85E-05 0.76 rs7421353 48.06 logistic Ml vs no Ml (follow-up) 2 0.0001092 0.76 rs7421353 48.06 logistic GE:AGE:SEX Ml vs control (at entry) 2 0.0001133 0.69 rs7421353 48.06 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0001154 0.75 rs7421353 48.06 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.000165 0.76 rs7421353 48.06 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0001868 0.75 rs7421353 48.06 logistic Ml vs control (follow-up) 2 0.0002034 0.70 rs7421353 48.06 logistic AGE:SEX Ml vs control (follow-up) 2 0.0002054 0.70 rs7421353 48.06 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0002598 0.76 rs7421353 48.06 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.000284 0.69 rs744564 215.60 logistic GE:AGE:SEX Ml vs control (at entry) 2 0.0002283 0.53 rs744564 215.60 logistic AGE:SEX Ml vs control (at entry) 2 0.0003183 0.53 rs744564 215.60 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0003367 0.53 rs745471 106.38 logistic AGE:SEX Ml vs control (at entry) 7 0.0001845 0.71 rs745471 106.38 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 0.0003273 0.71 rs745471 106.38 logistic Ml vs control (at entry) 7 0.0004475 0.71 rs7487640 91.24 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 0.0002755 1.41 rs7487640 91.24 logistic GE:AGE:SEX Ml vs control (follow-up) 12 0.0003777 1.41 rs7487640 91.24 logistic AGE:SEX Ml vs control (follow-up) 12 0.000446 1.41 rs7493192 114.70 logistic Ml vs control (follow-up) 14 2.02E-05 0.64 rs7493192 114.70 logistic AGE:SEX Ml vs control (follow-up) 14 4.86E-05 0.64 rs7493192 114.70 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 14 0.0001314 0.64 rs7493192 114.70 logistic GE:AGE:SEX Ml vs control (follow-up) 14 0.000139 0.64 rs7493192 114.70 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 14 0.0002957 0.64 rs750123 114.78 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 4.64E-05 1.38 rs750123 114.78 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 5.27E-05 1.38

rs750123 114.78 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 6.61 E-05 1.38 rs750123 114.78 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 7.46E-05 1.37 rs750123 114.78 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 7.93E-05 1.37 rs750123 114.78 logistic Ml vs no Ml (follow-up) 18 9.51 E-05 1.38 rs750123 114.78 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0001058 1.37 rs750123 114.78 logistic AGE:SEX Ml vs no Ml (follow-up) 18 0.0001197 1.38 rs750123 114.78 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0001601 1.38 rs750123 114.78 logistic Ml vs no Ml (at entry) 18 0.0001752 1.37 rs750123 114.78 logistic AGE:SEX Ml vs no Ml (at entry) 18 0.0002158 1.37 rs750123 114.78 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0002514 1.37 rs7501838 63.91 logistic Ml vs control (at entry) 17 8.04E-05 2.23 rs7501838 63.91 logistic AGE:SEX Ml vs control (at entry) 17 8.39E-05 2.23 rs7501838 63.91 logistic GE:AGE:SEX Ml vs control (at entry) 17 0.0001217 2.23 rs7501838 63.91 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 17 0.0002093 2.23 rs7505697 90.93 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 2.56E-05 0.76 rs7505697 90.93 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 3.08E-05 0.76 rs7505697 90.93 logistic Ml vs no Ml (follow-up) 18 3.69E-05 0.76 rs7505697 90.93 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 5.70E-05 0.76 rs7505697 90.93 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 6.89E-05 0.76 rs7505697 90.93 logistic AGE:SEX Ml vs no Ml (follow-up) 18 7.29E-05 0.76 rs7505697 90.93 logistic Ml vs no Ml (at entry) 18 9.59E-05 0.76 rs7505697 90.93 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 9.75E-05 0.76 rs7505697 90.93 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0001133 0.76 rs7505697 90.93 logistic AGE:SEX Ml vs no Ml (at entry) 18 0.0001704 0.76 rs7505697 90.93 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0001729 0.76 rs7505697 90.93 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0002486 0.76 rs750576 206.55 logistic Ml vs control (at entry) 2 5.59E-05 0.69 rs750576 206.55 logistic AGE:SEX Ml vs control (at entry) 2 8.28E-05 0.69 rs750576 206.55 logistic Ml vs control (follow-up) 2 0.0001884 0.69 rs750576 206.55 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0002337 0.69 rs750576 206.55 logistic GE:AGE:SEX Ml vs control (at entry) 2 0.0002599 0.69 rs750576 206.55 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0003129 0.69 rs750576 206.55 logistic AGE:SEX Ml vs control (follow-up) 2 0.0003592 0.69 rs751271 62.25 logistic GE:AGE:SEX Ml vs no Ml (at entry) 16 0.0004334 1.28 rs7516762 215.39 logistic AGE:SEX Ml vs control (follow-up) 1 2.45E-05 0.53 rs7516762 215.39 logistic GE:AGE:SEX Ml vs control (follow-up) 1 2.64E-05 0.53

rs7516762 215.39 logistic Ml vs control (follow-up) 1 2.69E-05 0.53 rs7516762 215.39 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 1 3.98E-05 0.53 rs7516762 215.39 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 9.34E-05 0.53 rs7516762 215.39 logistic AGE:SEX Ml vs control (at entry) 1 0.0004342 0.61 rs7516762 215.39 logistic Ml vs control (at entry) 1 0.0004805 0.61 rs7517569 239.94 logistic GE:AGE:SEX Ml vs control (at entry) 1 0.0002824 0.77 rs7517569 239.94 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 1 0.0004991 0.77 rs7517978 183.37 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 0.0002932 0.78 rs7517978 183.37 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 0.0003626 0.80 rs7528675 97.80 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 2.99E-06 0.56 rs7528675 97.80 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 1.51 E-05 0.57 rs7528675 97.80 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 1.66E-05 0.56 rs7528675 97.80 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 1.92E-05 0.56 rs7528675 97.80 logistic AGE:SEX Ml vs no Ml (follow-up) 1 2.15E-05 0.56 rs7528675 97.80 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 2.27E-05 0.56 rs7528675 97.80 logistic Ml vs no Ml (follow-up) 1 5.21 E-05 0.56 rs7528675 97.80 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 6.16E-05 0.57 rs7528675 97.80 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 7.46E-05 0.57 rs7528675 97.80 logistic AGE:SEX Ml vs no Ml (at entry) 1 8.24E-05 0.57 rs7528675 97.80 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 8.88E-05 0.57 rs7528675 97.80 logistic Ml vs no Ml (at entry) 1 0.0001648 0.57 rs7537656 148.56 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0004889 1.33 rs7547363 212.43 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 0.0002244 0.74 rs7547363 212.43 logistic Ml vs control (at entry) 1 0.000421 0.74 rs7552434 97.84 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 0.0001104 1.51 rs7552434 97.84 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 0.0004101 1.51 rs7559372 47.96 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 1.92E-05 0.27 rs7559372 47.96 logistic Ml vs no Ml (at entry) 2 2.21 E-05 0.27 rs7559372 47.96 logistic AGE:SEX Ml vs no Ml (at entry) 2 2.41 E-05 0.27 rs7559372 47.96 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2.94E-05 0.27 rs7559372 47.96 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 3.03E-05 0.27 rs7559372 47.96 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 8.38E-05 0.34 rs7559372 47.96 logistic AGE:SEX Ml vs control (at entry) 2 9.99E-05 0.26 rs7559372 47.96 logistic Ml vs no Ml (follow-up) 2 0.0001033 0.34 rs7559372 47.96 logistic Ml vs control (at entry) 2 0.0001053 0.26 rs7559372 47.96 logistic GE:AGE:SEX Ml vs control (at entry) 0.0001071 0.26

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rs7559372 47.96 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0001117 0.34 rs7559372 47.96 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 0.0001318 0.34 rs7559372 47.96 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 0.000141 0.34 rs7559372 47.96 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0002968 0.26 rs7559372 47.96 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0003229 0.27 rs7559372 47.96 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.000427 0.26 rs7559372 47.96 logistic Ml vs control (follow-up) 2 0.0004529 0.32 rs7559372 47.96 logistic AGE:SEX Ml vs control (follow-up) 2 0.0004823 0.32 rs7563316 116.28 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0001841 1.38 rs7563316 116.28 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0004846 1.38 rs7563316 116.28 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0004953 1.38 rs7565023 165.96 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 1.58E-06 0.21 rs7565023 165.96 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 2.23E-06 0.21 rs7565023 165.96 logistic Ml vs no Ml (at entry) 2 2.24E-06 0.21 rs7565023 165.96 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 2.56E-06 0.21 rs7565023 165.96 logistic AGE:SEX Ml vs no Ml (at entry) 2 4.72E-06 0.21 rs7565023 165.96 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 5.26E-06 0.21 rs7565023 165.96 logistic Ml vs no Ml (follow-up) 2 1.88E-05 0.30

OO rs7565023 165.96 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 2.05E-05 0.30 rs7565023 165.96 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 2.93E-05 0.30 rs7565023 165.96 logistic GE:AGE:SEX Ml vs control (at entry) 2 3.34E-05 0.25 rs7565023 165.96 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 3.96E-05 0.30 rs7565023 165.96 logistic AGE:SEX Ml vs no Ml (follow-up) 2 4.87E-05 0.30 rs7565023 165.96 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 4.99E-05 0.25 rs7565023 165.96 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 0.0001053 0.30 rs7565023 165.96 logistic Ml vs control (at entry) 2 0.0001452 0.25 rs7565023 165.96 logistic AGE:SEX Ml vs control (at entry) 2 0.0001545 0.25 rs7567280 186.05 logistic AGE:SEX Ml vs control (follow-up) 2 0.0003819 0.74 rs7570682 115.58 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0001228 1.37 rs7577717 192.98 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 3.18E-06 0.17 rs7577717 192.98 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 3.22E-06 0.10 rs7577717 192.98 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 4.12E-06 0.10 rs7577717 192.98 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 4.35E-06 0.10 rs7577717 192.98 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 4.70E-06 0.17 rs7577717 192.98 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 4.80E-06 0.17 rs7577717 192.98 logistic Ml vs no Ml (follow-up) 2 5.03E-06 0.17

rs7577717 192.98 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 5.45E-06 0.10 rs7577717 192.98 logistic Ml vs no Ml (at entry) 2 5.92E-06 0.10 rs7577717 192.98 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 8.76E-06 0.17 rs7577717 192.98 logistic AGE:SEX Ml vs no Ml (at entry) 2 9.49E-06 0.10 rs7577717 192.98 logistic AGE:SEX Ml vs no Ml (follow-up) 2 1.05E-05 0.17 rs7577717 192.98 logistic GE:AGE:SEX Ml vs control (at entry) 2 6.22E-05 0.14 rs7577717 192.98 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0001021 0.14 rs7577717 192.98 logistic GE:AGE:SEX Ml vs control (follow-up) 2 0.0001769 0.22 rs7577717 192.98 logistic AGE:SEX Ml vs control (at entry) 2 0.0002438 0.14 rs7577717 192.98 logistic Ml vs control (at entry) 2 0.0002531 0.14 rs7577717 192.98 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0003083 0.14 rs7577717 192.98 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 2 0.0003203 0.22 rs7577717 192.98 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 2 0.0004575 0.22 rs7590007 29.44 logistic Ml vs control (follow-up) 2 0.0001482 1.58 rs7590007 29.44 logistic Ml vs control (at entry) 2 0.000172 1.51 rs7590007 29.44 logistic AGE:SEX Ml vs control (at entry) 2 0.0002225 1.51 rs7590007 29.44 logistic AGE:SEX Ml vs control (follow-up) 2 0.0002259 1.58 rs7594119 86.36 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0001245 0.76 rs7594119 86.36 logistic Ml vs no Ml (at entry) 2 0.0001464 0.76 rs7594119 86.36 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0002998 0.76 rs7594119 86.36 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 0.0003376 0.76 rs7594119 86.36 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0004733 0.76 rs7598248 91.59 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 0.0004135 1.46 rs7613492 46.65 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 3 0.0002937 0.70 rs7613492 46.65 logistic GE:AGE:SEX Ml vs control (follow-up) 3 0.0002954 0.70 rs7613492 46.65 logistic Ml vs control (follow-up) 3 0.0003086 0.70 rs7616299 172.27 logistic AGE:SEX Ml vs control (at entry) 3 0.0001575 1.55 rs7616299 172.27 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0002277 1.38 rs7616299 172.27 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0002762 1.38 rs7616299 172.27 logistic Ml vs control (at entry) 3 0.0002942 1.55 rs7616299 172.27 logistic AGE:SEX Ml vs no Ml (follow-up) 3 0.0003878 1.35 rs7616299 172.27 logistic Ml vs no Ml (at entry) 3 0.0004428 1.38 rs7616299 172.27 logistic AGE:SEX Ml vs control (follow-up) 3 0.0004461 1.58 rs7616299 172.27 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0004807 1.38 rs7624432 190.91 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0001378 0.39 rs7624432 190.91 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0002205 0.39

rs7624432 190.91 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.000394 0.39 rs7628402 118.06 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 5.64E-06 0.13 rs7628402 118.06 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 7.34E-06 0.13 rs7628402 118.06 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 7.36E-06 0.13 rs7628402 118.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 7.97E-06 0.13 rs7628402 118.06 logistic Ml vs no Ml (at entry) 3 8.78E-06 0.13 rs7628402 118.06 logistic AGE:SEX Ml vs no Ml (at entry) 3 1.39E-05 0.13 rs7628402 118.06 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 3.62E-05 0.25 rs7628402 118.06 logistic Ml vs no Ml (follow-up) 3 4.36E-05 0.25 rs7628402 118.06 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 5.01 E-05 0.25 rs7628402 118.06 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 5.63E-05 0.25 rs7628402 118.06 logistic AGE:SEX Ml vs no Ml (follow-up) 3 8.96E-05 0.25 rs7628402 118.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 9.78E-05 0.25 rs7628402 118.06 logistic GE:AGE:SEX Ml vs control (at entry) 3 0.0001634 0.16 rs7628402 118.06 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 3 0.0002371 0.16 rs7628402 118.06 logistic AGE:SEX Ml vs control (at entry) 3 0.0002692 0.16 rs7628402 118.06 logistic Ml vs control (at entry) 3 0.0002761 0.16 rs7628779 48.57 logistic AGEiSEX Ml vs control (at entry) 3 0.0002678 0.42

O rs7628779 48.57 logistic AGEiSEX Ml vs control (follow-up) 3 0.0003278 0.42 rs7628779 48.57 logistic AGEiSEX Ml vs no Ml (at entry) 3 0.0003641 0.45 rs7628779 48.57 logistic Ml vs no Ml (at entry) 3 0.0003723 0.45 rs7628779 48.57 logistic AGEiSEX Ml vs no Ml (follow-up) 3 0.0004628 0.47 rs7628779 48.57 logistic Ml vs no Ml (follow-up) 3 0.0004809 0.47 rs7636153 165.73 logistic GEiAGEiACRiSEX Ml vs control (at entry) 3 0.0004111 0.74 rs7654444 117.91 logistic Ml vs no Ml (at entry) 4 3.13E-06 0.36 rs7654444 117.91 logistic GEiAGEiCRCLiSEX Ml vs no Ml (at entry) 4 3.71 E-06 0.36 rs7654444 117.91 logistic GEIAGEISEX Ml vs no Ml (at entry) 4 4.44E-06 0.36 rs7654444 117.91 logistic GEIAGEIACRISEX Ml vs no Ml (at entry) 4 4.93E-06 0.36 rs7654444 117.91 logistic AGEISEX Ml vs no Ml (at entry) 4 6.16E-06 0.36 rs7654444 117.91 logistic HBPIGEIAGEISEX Ml vs no Ml (at entry) 4 1.53E-05 0.36 rs7654444 117.91 logistic Ml vs no Ml (follow-up) 4 2.59E-05 0.43 rs7654444 117.91 logistic GEIAGEICRCLISEX Ml vs no Ml (follow-up) 4 3.48E-05 0.43 rs7654444 117.91 logistic GEIAGEISEX Ml vs no Ml (follow-up) 4 4.08E-05 0.43 rs7654444 117.91 logistic GEIAGEIACRISEX Ml vs no Ml (follow-up) 4 5.07E-05 0.43 rs7654444 117.91 logistic AGEISEX Ml vs no Ml (follow-up) 4 5.75E-05 0.43 rs7654444 117.91 logistic HBPIGEIAGEISEX Ml vs no Ml (follow-up) 4 0.0001673 0.43

rs7655585 181.64 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 4 0.0001022 1.50 rs7656673 44.93 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0003693 1.25 rs7660550 16.63 logistic Ml vs control (at entry) 4 0.0003727 0.57 rs7660550 16.63 logistic AGE:SEX Ml vs control (at entry) 4 0.0004674 0.57 rs7662513 77.47 logistic AGE:SEX Ml vs control (at entry) 4 0.0004006 1.65 rs7662513 77.47 logistic AGEiSEX Ml vs control (follow-up) 4 0.0004727 1.76 rs766857 126.46 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 10 1.13E-05 1.31 rs766857 126.46 logistic GE:AGE:SEX Ml vs control (at entry) 10 5.36E-05 1.31 rs766857 126.46 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 10 6.64E-05 1.31 rs766857 126.46 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 8.19E-05 1.31 rs766857 126.46 logistic GE:AGE:SEX Ml vs control (follow-up) 10 0.0001269 1.31 rs766857 126.46 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 10 0.0001866 1.31 rs7673867 114.91 logistic AGE:SEX Ml vs control (follow-up) 4 1.53E-05 0.63 rs7673867 114.91 logistic GE:AGE:SEX Ml vs control (follow-up) 4 2.29E-05 0.63 rs7673867 114.91 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 4 3.56E-05 0.63 rs7673867 114.91 logistic Ml vs control (follow-up) 4 6.11 E-05 0.63 rs7673867 114.91 logistic AGE:SEX Ml vs control (at entry) 4 0.0001392 0.68 _w rs7673867 114.91 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0002082 0.74

£ rs7673867 114.91 logistic GE:AGE:SEX Ml vs control (at entry) 4 0.0002654 0.68 rs7673867 114.91 logistic Ml vs control (at entry) 4 0.0003221 0.68 rs7673867 114.91 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 4 0.0003835 0.63 rs7673867 114.91 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 4 0.0004644 0.68 rs7673867 114.91 logistic AGE:SEX Ml vs no Ml (at entry) 4 0.0004968 0.74 rs7677760 99.54 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 4 0.0001248 0.75 rs7679792 99.62 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0003263 0.70 rs7679792 99.62 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0003769 0.71 rs7692314 16.65 logistic Ml vs control (at entry) 4 0.0003607 0.57 rs7692314 16.65 logistic AGE:SEX Ml vs control (at entry) 4 0.0004307 0.57 rs7692314 16.65 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 4 0.0004884 0.57 rs7693199 124.17 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0001298 1.43 rs7693199 124.17 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.0001814 1.42 rs7693199 124.17 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0002485 1.43 rs7693199 124.17 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0003276 1.43 rs7693199 124.17 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0003547 1.42 rs7693199 124.17 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0004353 1.43 rs7693199 124.17 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0004699 1.42

rs7699961 154.79 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 4.68E-05 0.33 rs7699961 154.79 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 5.14E-05 0.33 rs7699961 154.79 logistic Ml vs no Ml (at entry) 4 7.93E-05 0.33 rs7699961 154.79 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 8.36E-05 0.33 rs7699961 154.79 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 9.13E-05 0.33 rs7699961 154.79 logistic AGE:SEX Ml vs no Ml (at entry) 4 9.49E-05 0.33 rs7699961 154.79 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0001226 0.38 rs7699961 154.79 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0001593 0.38 rs7699961 154.79 logistic Ml vs no Ml (follow-up) 4 0.0001877 0.38 rs7699961 154.79 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0002312 0.38 rs7699961 154.79 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0002398 0.38 rs7699961 154.79 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0002415 0.38 rs7701321 120.20 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 5 0.0004713 1.23 rs7708421 28.55 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 5 0.0002152 1.18 rs7714857 157.99 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 2.70E-06 0.16 rs7714857 157.99 logistic Ml vs no Ml (at entry) 5 3.42E-06 0.16 rs7714857 157.99 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 3.94E-06 0.16 rs7714857 157.99 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 4.20E-06 0.16 rs7714857 157.99 logistic AGE:SEX Ml vs no Ml (at entry) 5 6.00E-06 0.16 rs7714857 157.99 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 1.18E-05 0.16 rs7714857 157.99 logistic Ml vs no Ml (follow-up) 5 2.35E-05 0.27 rs7714857 157.99 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 2.41 E-05 0.27 rs7714857 157.99 logistic GE:AGE:SEX Ml vs control (at entry) 5 3.70E-05 0.18 rs7714857 157.99 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 3.73E-05 0.27 rs7714857 157.99 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 5 4.60E-05 0.27 rs7714857 157.99 logistic AGEiSEX Ml vs no Ml (follow-up) 5 5.24E-05 0.27 rs7714857 157.99 logistic Ml vs control (at entry) 5 5.24E-05 0.18 rs7714857 157.99 logistic AGE:SEX Ml vs control (at entry) 5 6.35E-05 0.18 rs7714857 157.99 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 6.75E-05 0.18 rs7714857 157.99 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0002063 0.27 rs7714857 157.99 logistic Ml vs control (follow-up) 5 0.0003847 0.27 rs7714857 157.99 logistic GE:AGE:SEX Ml vs control (follow-up) 5 0.0004036 0.27 rs7714857 157.99 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 5 0.0004503 0.18 rs7714857 157.99 logistic AGE:SEX Ml vs control (follow-up) 5 0.0004658 0.27 rs7733733 38.00 logistic AGE:SEX Ml vs control (follow-up) 5 0.0004426 1.59 rs7738340 121.81 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0004075 0.78

rs7745577 136.82 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 6 0.0001785 0.63 rs7745577 136.82 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.0004093 0.68 rs7748736 11.51 logistic Ml vs control (follow-up) 6 0.000334 1.41 rs7748736 11.51 logistic AGE:SEX Ml vs control (follow-up) 6 0.0003411 1.41 rs7750426 166.65 logistic AGE:SEX Ml vs control (at entry) 6 0.0004608 0.73 rs7752425 70.98 logistic AGE:SEX Ml vs control (follow-up) 6 0.0001091 1.46 rs7752425 70.98 logistic Ml vs control (follow-up) 6 0.0002984 1.46 rs7756362 146.72 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 6.55E-05 0.72 rs7756362 146.72 logistic AGE:SEX Ml vs no Ml (at entry) 6 0.0002427 0.75 rs7756362 146.72 logistic Ml vs no Ml (at entry) 6 0.0002882 0.75 rs7756362 146.72 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 0.000378 0.75 rs7756362 146.72 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0004094 0.75 rs7765427 91.20 logistic AGE:SEX Ml vs control (follow-up) 6 0.00033 1.55 rs7765427 91.20 logistic Ml vs control (follow-up) 6 0.0003631 1.55 rs7765427 91.20 logistic Ml vs control (at entry) 6 0.0003968 1.47 rs7777679 41.08 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 7 0.0001772 1.83 rs7778110 51.06 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 7 0.0002289 1.23 rs7779004 124.67 logistic GE:AGE:SEX Ml vs no Ml (at entry) 7 7.09E-06 0.22 rs7779004 124.67 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 7 7.55E-06 0.22 rs7779004 124.67 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 7 9.58E-06 0.22 rs7779004 124.67 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 7 9.65E-06 0.22 rs7779004 124.67 logistic Ml vs no Ml (at entry) 7 9.82E-06 0.22 rs7779004 124.67 logistic AGEiSEX Ml vs no Ml (at entry) 7 2.35E-05 0.22 rs7779004 124.67 logistic Ml vs no Ml (follow-up) 7 4.41 E-05 0.30 rs7779004 124.67 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 4.43E-05 0.30 rs7779004 124.67 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 6.12E-05 0.30 rs7779004 124.67 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 6.78E-05 0.30 rs7779004 124.67 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 7 7.09E-05 0.30 rs7779004 124.67 logistic AGEiSEX Ml vs no Ml (follow-up) 7 0.0001338 0.30 rs7779004 124.67 logistic GE:AGE:SEX Ml vs control (at entry) 7 0.0001945 0.27 rs7779004 124.67 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 0.0002758 0.27 rs778354 239.98 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 0.0004005 1.29 rs7795090 78.61 logistic GE:AGE:SEX Ml vs no Ml (at entry) 7 1.60E-05 0.08 rs7795090 78.61 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 7 1.78E-05 0.08 rs7795090 78.61 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 7 1.84E-05 0.08 rs7795090 78.61 logistic Ml vs no Ml (at entry) 7 2.35E-05 0.08

rs7795090 78.61 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 7 2.69E-05 0.08 rs7795090 78.61 logistic AGEiSEX Ml vs no Ml (at entry) 7 3.93E-05 0.08 rs7795090 78.61 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 7 4.78E-05 0.22 rs7795090 78.61 logistic Ml vs no Ml (follow-up) 7 5.29E-05 0.22 rs7795090 78.61 logistic GE:AGE:SEX Ml vs control (at entry) 7 5.68E-05 0.09 rs7795090 78.61 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 7 5.82E-05 0.22 rs7795090 78.61 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 7 6.32E-05 0.22 rs7795090 78.61 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 7 6.84E-05 0.09 rs7795090 78.61 logistic Ml vs control (at entry) 7 7.93E-05 0.09 rs7795090 78.61 logistic AGE:SEX Ml vs no Ml (follow-up) 7 0.0001391 0.22 rs7795090 78.61 logistic AGE:SEX Ml vs control (at entry) 7 0.0001475 0.09 rs7795090 78.61 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 7 0.0002056 0.22 rs7795796 128.19 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 7 0.0002947 0.90 rs7798679 70.07 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 7 0.0003348 0.80 rs7822883 66.12 logistic AGE:SEX Ml vs control (at entry) 8 0.0004848 0.60 rs782593 76.92 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 2 0.0004844 1.30 rs7826102 6.91 logistic GE:AGE:SEX Ml vs control (at entry) 8 0.0002929 1.58 _w rs7826102 6.91 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 0.0004213 1.58 j-J rs7830390 99.90 logistic GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0001217 0.55 rs7830390 99.90 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 8 0.0001447 0.55 rs7830390 99.90 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 8 0.0001475 0.55 rs7830390 99.90 logistic Ml vs no Ml (at entry) 8 0.000186 0.55 rs7830390 99.90 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 8 0.0002292 0.55 rs7830390 99.90 logistic AGE:SEX Ml vs no Ml (at entry) 8 0.0002639 0.55 rs783073 101.77 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0003935 1.32 rs783250 99.40 logistic AGE:SEX Ml vs control (follow-up) 17 4.75E-05 1.46 rs783250 99.40 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 17 5.97E-05 1.46 rs783250 99.40 logistic AGE:SEX Ml vs control (at entry) 17 8.81 E-05 1.42 rs783250 99.40 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 17 9.97E-05 1.46 rs783250 99.40 logistic Ml vs control (follow-up) 17 0.0001108 1.46 rs783250 99.40 logistic Ml vs control (at entry) 17 0.0001355 1.42 rs783250 99.40 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 17 0.0001501 1.31 rs783250 99.40 logistic AGE:SEX Ml vs no Ml (follow-up) 17 0.0001593 1.31 rs783250 99.40 logistic Ml vs no Ml (follow-up) 17 0.0001618 1.31 rs783250 99.40 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 17 0.0001712 1.31 rs783250 99.40 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 17 0.0001806 1.42

rs783250 99.40 logistic GE:AGE:SEX Ml vs control (follow-up) 17 0.0002237 1.46 rs783250 99.40 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 17 0.000263 1.46 rs783250 99.40 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 17 0.0003284 1.31 rs783250 99.40 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 17 0.0004456 1.42 rs7834089 53.21 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 8 0.0002189 0.74 rs7835152 66.13 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.0003391 0.78 rs783841 70.27 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 1 9.90E-06 1.52 rs783841 70.27 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 1 0.0001183 1.55 rs783841 70.27 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 1 0.0001814 1.52 rs783841 70.27 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 1 0.0003858 1.55 rs7838821 6.07 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 8 0.0001135 2.76 rs7838821 6.07 logistic AGE:SEX Ml vs control (at entry) 8 0.000162 2.76 rs7838821 6.07 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 0.000164 2.76 rs7838821 6.07 logistic GE:AGE:SEX Ml vs control (at entry) 8 0.0002097 2.76 rs7838821 6.07 logistic Ml vs control (at entry) 8 0.0002128 2.76 rs7843358 66.42 logistic Ml vs control (at entry) 8 0.0001204 0.54 rs7843358 66.42 logistic AGE:SEX Ml vs control (at entry) 8 0.0001753 0.54 rs7843358 66.42 logistic Ml vs control (follow-up) 8 0.0002531 0.55 rs7843358 66.42 logistic AGE:SEX Ml vs control (follow-up) 8 0.000269 0.55 rs7844027 147.69 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.0003147 0.72 rs7863451 139.04 logistic AGE:SEX Ml vs control (follow-up) 9 0.0003773 1.42 rs7863451 139.04 logistic Ml vs control (follow-up) 9 0.0004483 1.42 rs788216 53.01 logistic GE:AGE:CRCLSEX Ml vs control (follow-up) 10 0.0001147 1.51 rs788216 53.01 logistic GE:AGE:SEX Ml vs control (follow-up) 10 0.0001648 1.51 rs788216 53.01 logistic Ml vs control (follow-up) 10 0.0003084 1.51 rs789030 1.09 logistic Ml vs control (follow-up) 18 0.0002679 1.51 rs789030 1.09 logistic AGE:SEX Ml vs control (follow-up) 18 0.0004923 1.51 rs7896663 145.96 logistic Ml vs no Ml (follow-up) 10 9.06E-05 1.47 rs7896663 145.96 logistic Ml vs no Ml (at entry) 10 9.83E-05 1.47 rs7896663 145.96 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 10 0.000129 1.47 rs7896663 145.96 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 10 0.000138 1.47 rs7896663 145.96 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 0.0001644 1.47 rs7896663 145.96 logistic GE:AGE:SEX Ml vs no Ml (at entry) 10 0.0001724 1.47 rs7896663 145.96 logistic AGE:SEX Ml vs no Ml (at entry) 10 0.0001753 1.47 rs7896663 145.96 logistic AGE:SEX Ml vs no Ml (follow-up) 10 0.0001782 1.47 rs7896663 145.96 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 10 0.0001818 1.47

rs7896663 145.96 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0002053 1.47 rs7900746 139.50 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 0.0004841 0.79 rs7901463 76.73 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 10 0.000434 0.76 rs7901744 81.91 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0004033 1.26 rs7911998 147.64 logistic AGE:SEX Ml vs control (follow-up) 10 0.0002088 1.86 rs7911998 147.64 logistic Ml vs control (follow-up) 10 0.0002118 1.86 rs7913419 34.71 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 10 0.0004839 0.83 rs7921545 35.76 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 10 0.0003406 0.75 rs7927704 103.65 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 11 0.0001704 0.65 rs7927704 103.65 logistic GE:AGE:SEX Ml vs control (at entry) 11 0.0002205 0.65 rs7927704 103.65 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 0.0003459 0.70 rs7927704 103.65 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 0.0004886 0.70 rs793557 123.26 logistic Ml vs no Ml (at entry) 3 0.0003127 1.34 rs793557 123.26 logistic AGE:SEX Ml vs no Ml (at entry) 3 0.0003439 1.34 rs7940927 47.62 logistic AGE:SEX Ml vs no Ml (follow-up) 11 0.0001206 0.73 rs7940927 47.62 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 11 0.0001926 0.73 rs7940927 47.62 logistic AGE:SEX Ml vs control (follow-up) 11 0.0002463 0.67 rs7940927 47.62 logistic Ml vs control (follow-up) 11 0.0002523 0.67 rs7940927 47.62 logistic Ml vs no Ml (follow-up) 11 0.0002541 0.73 rs7940927 47.62 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 11 0.0002861 0.73 rs7940927 47.62 logistic AGEiSEX Ml vs control (at entry) 11 0.0003277 0.70 rs7940927 47.62 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0003371 0.74 rs7940927 47.62 logistic Ml vs control (at entry) 11 0.0003935 0.70 rs7940927 47.62 logistic GE:AGE:SEX Ml vs control (follow-up) 11 0.0004694 0.67 rs7945575 89.30 logistic AGE:SEX Ml vs control (at entry) 11 8.10E-05 1.39 rs7945575 89.30 logistic AGE:SEX Ml vs no Ml (follow-up) 11 9.37E-05 1.30 rs7945575 89.30 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0001315 1.30 rs7945575 89.30 logistic Ml vs control (at entry) 11 0.0001478 1.39 rs7945575 89.30 logistic Ml vs no Ml (follow-up) 11 0.0001926 1.30 rs7945575 89.30 logistic Ml vs no Ml (at entry) 11 0.0002345 1.30 rs7956826 91.03 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 12 0.0004349 1.30 rs7960483 59.15 logistic AGE:SEX Ml vs control (at entry) 12 0.0004917 1.36 rs7966105 93.71 logistic AGE:SEX Ml vs control (at entry) 12 0.0002059 0.71 rs7966105 93.71 logistic Ml vs control (at entry) 12 0.0002095 0.71 rs7966105 93.71 logistic Ml vs control (follow-up) 12 0.0002781 0.69 rs7966105 93.71 logistic AGE:SEX Ml vs control (follow-up) 12 0.0003338 0.69

rs796694 175.37 logistic AGE:SEX Ml vs no Ml (follow-up) 1 0.0003083 0.70 rs796694 175.37 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0004148 0.70 rs796694 175.37 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.0004607 0.70 rs7972470 17.04 logistic AGE:SEX Ml vs control (follow-up) 12 1.72E-05 0.42 rs7972470 17.04 logistic GE:AGE:SEX Ml vs control (follow-up) 12 3.04E-05 0.42 rs7972470 17.04 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 3.56E-05 0.42 rs7972470 17.04 logistic Ml vs control (follow-up) 12 4.31 E-05 0.42 rs7972470 17.04 logistic AGEiSEX Ml vs control (at entry) 12 0.0001176 0.47 rs7972470 17.04 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0001426 0.42 rs7972470 17.04 logistic GE:AGE:SEX Ml vs control (at entry) 12 0.0001525 0.47 rs7972470 17.04 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 0.0001926 0.47 rs7972470 17.04 logistic Ml vs control (at entry) 12 0.0002544 0.47 rs7975586 74.59 logistic AGE:SEX Ml vs control (at entry) 12 0.0001246 0.65 rs7975586 74.59 logistic AGE:SEX Ml vs control (follow-up) 12 0.0002233 0.64 rs7975586 74.59 logistic Ml vs control (at entry) 12 0.0002353 0.65 rs7975586 74.59 logistic Ml vs control (follow-up) 12 0.0004937 0.64 rs7977461 102.09 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 0.0004084 1.36 rs7979816 118.60 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 5.14E-05 0.77 rs7979816 118.60 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.0002167 0.80 rs7980576 53.37 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 12 0.0002023 1.28 rs798442 16.51 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 2 0.0002195 1.80 rs798442 16.51 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0002257 1.66 rs8008963 49.14 logistic GE:AGE:SEX Ml vs control (follow-up) 14 0.0004449 1.36 rs8015136 44.25 logistic Ml vs no Ml (at entry) 14 0.0003325 1.60 rs8021814 50.96 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 14 0.000377 1.39 rs8021814 50.96 logistic GE:AGE:SEX Ml vs control (follow-up) 14 0.0003969 1.39 rs8023274 72.40 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 15 0.0002124 1.67 rs8023274 72.40 logistic GE:AGE:SEX Ml vs control (at entry) 15 0.0004768 1.67 rs8033957 37.32 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 15 0.0001384 1.68 rs8033957 37.32 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 15 0.0002043 1.75 rs8033957 37.32 logistic GE:AGE:SEX Ml vs control (at entry) 15 0.0002407 1.68 rs8033957 37.32 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 15 0.000337 1.68 rs8033957 37.32 logistic GE:AGE:SEX Ml vs control (follow-up) 15 0.0003616 1.75 rs8033957 37.32 logistic AGE:SEX Ml vs control (at entry) 15 0.000374 1.68 rs8041258 68.92 logistic GE:AGE:SEX Ml vs control (follow-up) 15 0.0003987 0.44 rs8043148 114.87 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 15 0.0002987 1.90

rs8043148 114.87 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 15 0.0003597 2.62 rs8050099 127.42 logistic Ml vs no Ml (at entry) 16 3.48E-05 1.37 rs8050099 127.42 logistic AGE:SEX Ml vs no Ml (at entry) 16 4.65E-05 1.37 rs8050099 127.42 logistic Ml vs no Ml (follow-up) 16 5.09E-05 1.35 rs8050099 127.42 logistic GE:AGE:SEX Ml vs no Ml (at entry) 16 6.89E-05 1.37 rs8050099 127.42 logistic AGE:SEX Ml vs no Ml (follow-up) 16 6.99E-05 1.35 rs8050099 127.42 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 16 7.70E-05 1.37 rs8050099 127.42 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 16 8.89E-05 1.37 rs8050099 127.42 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 16 9.50E-05 1.35 rs8050099 127.42 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 16 0.0001096 1.35 rs8050099 127.42 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 16 0.000122 1.35 rs8050099 127.42 logistic Ml vs control (at entry) 16 0.0001556 1.44 rs8050099 127.42 logistic GE:AGE:SEX Ml vs control (at entry) 16 0.0002062 1.44 rs8050099 127.42 logistic AGE:SEX Ml vs control (at entry) 16 0.0002075 1.44 rs8050099 127.42 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 16 0.0002872 1.44 rs8050099 127.42 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 16 0.0003553 1.37 rs8050099 127.42 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 16 0.0004927 1.35 rs8061285 9.85 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 16 0.0003859 1.17

OO rs8072988 53.22 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 17 0.0002542 1.26 rs8074960 98.25 logistic Ml vs control (at entry) 17 0.0004938 1.45 rs8078319 61.43 logistic Ml vs control (follow-up) 17 0.000196 0.53 rs8078319 61.43 logistic AGE:SEX Ml vs control (follow-up) 17 0.000207 0.53 rs8078844 53.19 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 17 0.0003247 1.25 rs8094588 72.79 logistic Ml vs control (at entry) 18 4.86E-05 0.69 rs8094588 72.79 logistic AGE:SEX Ml vs control (at entry) 18 6.55E-05 0.69 rs8094588 72.79 logistic Ml vs control (follow-up) 18 0.0001065 0.68 rs8094588 72.79 logistic AGE:SEX Ml vs control (follow-up) 18 0.0001284 0.68 rs8094588 72.79 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 18 0.0003703 0.69 rs8094588 72.79 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0003912 0.69 rs8094588 72.79 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 18 0.0004617 0.68 rs8097577 65.81 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0002738 1.25 rs8097774 95.80 logistic AGE:SEX Ml vs control (at entry) 18 0.0004695 0.75 rs8100438 48.58 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 19 0.00038 1.23 rs8112882 103.01 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 19 0.0003697 0.84 rs8113891 32.96 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 20 0.0002452 1.29 rs8113891 32.96 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 20 0.0004122 1.29

rs8119959 32.96 logistic GE:AGE:ACR:SEX Ml vs no WII (follow-up) 20 0.0003447 1.28 rs8120943 54.10 logistic GE:AGE:SEX Ml vs control (at entry) 20 0.0001339 0.68 rs8120943 54.10 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 20 0.0001929 0.68 rs8122510 54.11 logistic GE:AGE:SEX Ml vs control (at entry) 20 0.0001365 0.68 rs8122510 54.11 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 20 0.0001975 0.68 rs8176345 71.55 logistic Ml vs control (follow-up) 12 0.0001518 0.42 rs8187945 67.81 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 9 0.0003913 1.97 rs818944 98.06 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0003124 0.73 rs818944 98.06 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0003263 0.73 rs820296 62.37 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 3 0.0003417 1.63 rs824633 14.50 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0001115 0.47 rs824633 14.50 logistic GE:AGE:SEX Ml vs no Ml (at entry) 5 0.0001415 0.47 rs824633 14.50 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 5 0.0001454 0.47 rs824633 14.50 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0001674 0.47 rs826686 119.56 logistic Ml vs control (follow-up) 2 0.0002294 0.61 rs826686 119.56 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 2 0.000322 0.61 rs826686 119.56 logistic AGE:SEX Ml vs control (follow-up) 2 0.0003259 0.61 rs826686 119.56 logistic GE:AGE:SEX Ml vs control (follow-up) 2 0.0003385 0.61 rs826692 119.57 logistic Ml vs control (follow-up) 2 0.0001761 0.60 rs826692 119.57 logistic AGE:SEX Ml vs control (follow-up) 2 0.0002614 0.60 rs826692 119.57 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 2 0.0002693 0.60 rs826692 119.57 logistic GE:AGE:SEX Ml vs control (follow-up) 2 0.0002784 0.60 rs831179 28.56 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 5 0.0003396 1.17 rs839878 141.28 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 0.0001346 1.36 rs839878 141.28 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0001943 1.36 rs839878 141.28 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0002032 1.36 rs839878 141.28 logistic AGEiSEX Ml vs no Ml (at entry) 1 0.000231 1.36 rs839878 141.28 logistic Ml vs no Ml (at entry) 1 0.0004536 1.36 rs839879 141.28 logistic AGE:SEX Ml vs no Ml (at entry) 1 2.93E-05 1.54 rs839879 141.28 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 3.61 E-05 1.54 rs839879 141.28 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 5.17E-05 1.54 rs839879 141.28 logistic Ml vs no Ml (at entry) 1 6.80E-05 1.54 rs839879 141.28 logistic AGE:SEX Ml vs no Ml (follow-up) 1 0.0001306 1.48 rs839879 141.28 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0001691 1.48 rs839879 141.28 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 0.0002366 1.48 rs839879 141.28 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 0.0002716 1.54

rs839879 141.28 logistic Ml vs no Ml (follow-up) 1 0.0003247 1.48 rs839879 141.28 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0003947 1.54 rs844116 54.73 logistic AGE:SEX Ml vs no Ml (at entry) 12 0.0003026 2.90 rs853753 232.33 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0002698 0.66 rs853753 232.33 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.0004135 0.67 rs8587 123.87 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 16 0.0001065 1.33 rs8587 123.87 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 16 0.0001949 1.24 rs858942 72.67 logistic AGE:SEX Ml vs control (follow-up) 2 1.00E-05 1.93 rs858942 72.67 logistic AGE:SEX Ml vs control (at entry) 2 2.19E-05 1.76 rs858942 72.67 logistic Ml vs control (follow-up) 2 2.28E-05 1.93 rs858942 72.67 logistic Ml vs control (at entry) 2 3.84E-05 1.76 rs858942 72.67 logistic GE:AGE:SEX Ml vs control (follow-up) 2 8.06E-05 1.93 rs858942 72.67 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 2 0.0001441 1.93 rs858942 72.67 logistic GE:AGE:SEX Ml vs control (at entry) 2 0.0002378 1.76 rs858942 72.67 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0004888 1.76 rs865094 73.53 logistic GE:AGE:SEX Ml vs control (at entry) 16 0.0002624 1.55 rs865094 73.53 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 16 0.0002766 1.55 _w rs865094 73.53 logistic AGE:SEX Ml vs control (at entry) 16 0.0003307 1.55 έ rs865094 73.53 logistic Ml vs control (at entry) 16 0.0003326 1.55 rs870033 47.81 logistic Ml vs control (follow-up) 8 0.0004657 1.70 rs870254 124.20 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 0.000116 1.33 rs870254 124.20 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0001575 1.33 rs870254 124.20 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 0.0002078 1.33 rs870254 124.20 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0002674 1.33 rs870254 124.20 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0004766 1.33 rs870254 124.20 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 4 0.0004966 1.38 rs870695 65.44 logistic AGEiSEX Ml vs no Ml (at entry) 9 0.0003365 0.78 rs875772 172.63 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0002715 0.79 rs875772 172.63 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 6 0.0004054 0.78 rs880026 65.68 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0003847 1.26 rs880026 65.68 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 0.000414 1.26 rs882612 41.07 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 7 0.0003286 1.82 rs885076 145.13 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 5.28E-05 1.40 rs885076 145.13 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 8.90E-05 1.40 rs885076 145.13 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.000108 1.40 rs885076 145.13 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.00014 1.40

rs885076 145.13 logistic GE:AGE:SEX Ml vs control (at entry) 3 0.0001924 1.42 rs885076 145.13 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 3 0.0002003 1.42 rs885076 145.13 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 0.0002179 1.42 rs885076 145.13 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0002303 1.40 rs885076 145.13 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 0.0002912 1.40 rs885161 64.00 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 10 0.000265 0.80 rs885161 64.00 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 10 0.0003062 0.80 rs885162 64.00 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 10 0.0003082 0.81 rs885162 64.00 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 10 0.0003382 0.80 rs889268 54.57 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 5 0.0002763 0.76 rs895193 72.64 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 13 0.000331 1.35 rs895193 72.64 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 0.000347 1.34 rs900668 97.18 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0003659 1.53 rs900668 97.18 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0004019 1.53 rs902581 101.89 logistic AGE:SEX Ml vs control (follow-up) 18 2.71 E-05 0.43 rs902581 101.89 logistic Ml vs control (follow-up) 18 4.49E-05 0.43 rs902581 101.89 logistic GE:AGE:SEX Ml vs control (follow-up) 18 5.37E-05 0.43

W rs902581 101.89 logistic Ml vs no Ml (at entry) 18 8.36E-05 0.49 rs902581 101.89 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 9.34E-05 0.43 rs902581 101.89 logistic AGE:SEX Ml vs no Ml (at entry) 18 0.0001059 0.49 rs902581 101.89 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0001111 0.49 rs902581 101.89 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0001436 0.49 rs902581 101.89 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0001524 0.49 rs902581 101.89 logistic Ml vs no Ml (follow-up) 18 0.0001983 0.52 rs902581 101.89 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0002473 0.52 rs902581 101.89 logistic AGE:SEX Ml vs control (at entry) 18 0.000248 0.47 rs902581 101.89 logistic AGE:SEX Ml vs no Ml (follow-up) 18 0.0002523 0.52 rs902581 101.89 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 18 0.0002839 0.43 rs902581 101.89 logistic Ml vs control (at entry) 18 0.0003207 0.47 rs902581 101.89 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 0.0003292 0.52 rs902581 101.89 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 0.0003834 0.52 rs902581 101.89 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0004183 0.47 rs908916 115.60 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 2 0.0001286 1.50 rs908916 115.60 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 2 0.0002605 1.50 rs910534 151.77 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 6.56E-05 1.32 rs910534 151.77 logistic AGEiSEX Ml vs no Ml (at entry) 6 6.77E-05 1.32

rs910534 151.77 logistic Ml vs no Ml (at entry) 6 8.53E-05 1.32 rs910534 151.77 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 8.58E-05 1.32 rs910534 151.77 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 9.93E-05 1.31 rs910534 151.77 logistic AGE:SEX Ml vs no Ml (follow-up) 6 1.00E-04 1.31 rs910534 151.77 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0001287 1.31 rs910534 151.77 logistic Ml vs no Ml (follow-up) 6 0.000135 1.31 rs910534 151.77 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0002416 1.31 rs910534 151.77 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.000261 1.32 rs910534 151.77 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0003476 1.32 rs914993 104.53 logistic Ml vs no Ml (follow-up) 9 8.62E-06 0.17 rs914993 104.53 logistic Ml vs no Ml (at entry) 9 1.18E-05 0.08 rs914993 104.53 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 9 1.21 E-05 0.08 rs914993 104.53 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 9 1.22E-05 0.17 rs914993 104.53 logistic GE:AGE:SEX Ml vs no Ml (at entry) 9 1.24E-05 0.08 rs914993 104.53 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 9 1.27E-05 0.08 rs914993 104.53 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 9 1.36E-05 0.17 rs914993 104.53 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 9 1.52E-05 0.08 _w rs914993 104.53 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 9 1.70E-05 0.17

6 rs914993 104.53 logistic AGE:SEX Ml vs no Ml (at entry) 9 1.93E-05 0.08 rs914993 104.53 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 9 2.08E-05 0.17 rs914993 104.53 logistic AGE:SEX Ml vs no Ml (follow-up) 9 2.11 E-05 0.17 rs914993 104.53 logistic GE:AGE:SEX Ml vs control (at entry) 9 0.0001459 0.10 rs914993 104.53 logistic Ml vs control (at entry) 9 0.000147 0.10 rs914993 104.53 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0001733 0.19 rs914993 104.53 logistic Ml vs control (follow-up) 9 0.0001779 0.19 rs914993 104.53 logistic AGE:SEX Ml vs control (at entry) 9 0.0001947 0.10 rs914993 104.53 logistic AGE:SEX Ml vs control (follow-up) 9 0.0002311 0.19 rs914993 104.53 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 9 0.0002828 0.10 rs914993 104.53 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 0.0003802 0.19 rs918107 118.54 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 12 6.88E-05 0.79 rs918107 118.54 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.000252 0.81 rs9295173 166.66 logistic AGE:SEX Ml vs control (at entry) 6 0.0001933 0.73 rs9295173 166.66 logistic Ml vs control (at entry) 6 0.0002498 0.73 rs9296495 23.89 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 0.0004561 0.79 rs9298281 94.35 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 8 0.0003377 0.79 rs9299046 15.56 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 9 3.45E-05 1.43

rs930223 99.73 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 19 0.0004666 0.60 rs9306459 13.67 logistic GE:AGE:SEX Ml vs control (at entry) 22 0.0002688 0.70 rs9306459 13.67 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 22 0.0003043 0.70 rs9306459 13.67 logistic AGE:SEX Ml vs control (at entry) 22 0.0004203 0.70 rs9307847 148.79 logistic GE:AGE:SEX Ml vs control (at entry) 4 0.0002151 0.72 rs9307847 148.79 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 4 0.000262 0.72 rs9307847 148.79 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 4 0.0002895 0.72 rs9310350 106.60 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0003764 1.34 rs9316670 45.46 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 13 0.0001229 1.39 rs9328513 15.39 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.000114 0.78 rs9328513 15.39 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.000117 0.78 rs9328513 15.39 logistic GE:AGE:SEX Ml vs control (at entry) 6 0.0001317 0.74 rs9328513 15.39 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 6 0.0001756 0.74 rs9328513 15.39 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0003028 0.78 rs9328513 15.39 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 0.000308 0.78 rs9328513 15.39 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0003716 0.78 rs9328513 15.39 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0003887 0.78 rs9329165 14.54 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0003954 1.28

4- rs9329166 14.54 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 8 0.0004819 1.28 rs9331931 54.37 logistic AGE:SEX Ml vs control (at entry) 8 0.000228 0.72 rs9331931 54.37 logistic AGE:SEX Ml vs no Ml (follow-up) 8 0.0003764 0.77 rs933654 165.23 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 5 0.0004245 0.82 rs9346035 80.34 logistic AGE:SEX Ml vs control (follow-up) 6 3.62E-05 0.68 rs9346035 80.34 logistic Ml vs control (follow-up) 6 7.33E-05 0.68 rs9346035 80.34 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 6 0.0003017 0.68 rs9346035 80.34 logistic GE:AGE:SEX Ml vs control (follow-up) 6 0.0003688 0.68 rs9354810 80.40 logistic AGE:SEX Ml vs control (follow-up) 6 0.0003241 0.71 rs9354810 80.40 logistic Ml vs control (follow-up) 6 0.0004966 0.71 rs9360790 87.61 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 3.39E-06 0.20 rs9360790 87.61 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 4.54E-06 0.20 rs9360790 87.61 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 4.54E-06 0.20 rs9360790 87.61 logistic Ml vs no Ml (at entry) 6 4.83E-06 0.20 rs9360790 87.61 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 6.07E-06 0.20 rs9360790 87.61 logistic AGE:SEX Ml vs no Ml (at entry) 6 1.00E-05 0.20 rs9360790 87.61 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 4.27E-05 0.31 rs9360790 87.61 logistic Ml vs no Ml (follow-up) 6 4.52E-05 0.31

rs9360790 87.61 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 5.86E-05 0.31 rs9360790 87.61 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 6.54E-05 0.31 rs9360790 87.61 logistic GE:AGE:SEX Ml vs control (at entry) 6 8.97E-05 0.25 rs9360790 87.61 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0001165 0.31 rs9360790 87.61 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 6 0.0001253 0.25 rs9360790 87.61 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001276 0.31 rs9360790 87.61 logistic AGE:SEX Ml vs control (at entry) 6 0.0003021 0.25 rs9360790 87.61 logistic Ml vs control (at entry) 6 0.000331 0.25 rs9363771 80.35 logistic AGE:SEX Ml vs control (follow-up) 6 1.64E-05 0.66 rs9363771 80.35 logistic Ml vs control (follow-up) 6 3.07E-05 0.66 rs9363771 80.35 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 0.0001515 0.66 rs9363771 80.35 logistic GE:AGE:SEX Ml vs control (follow-up) 0.0001886 0.66 rs9373118 136.05 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 6 0.0001112 1.41 rs9376083 136.10 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 6 6.18E-05 1.54 rs9376083 136.10 logistic GE:AGE:SEX Ml vs control (at entry) 6 0.0004239 1.54 rs9385740 136.83 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 6 0.0002616 0.57 rs9385740 136.83 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.000324 0.59 _w rs9389245 136.02 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 6 5.77E-05 1.78 t rs9400016 103.36 logistic Ml vs no Ml (at entry) 6 2.67E-05 0.67 rs9400016 103.36 logistic AGE:SEX Ml vs no Ml (at entry) 6 4.47E-05 0.67 rs9400016 103.36 logistic Ml vs no Ml (follow-up) 6 6.95E-05 0.69 rs9400016 103.36 logistic GE:AGE:SEX Ml vs no Ml (at entry) 6 7.22E-05 0.67 rs9400016 103.36 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 6 9.01 E-05 0.67 rs9400016 103.36 logistic AGE:SEX Ml vs no Ml (follow-up) 6 0.0001251 0.69 rs9400016 103.36 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0001829 0.69 rs9400016 103.36 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0001938 0.67 rs9400016 103.36 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 6 0.0002277 0.69 rs9400016 103.36 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 6 0.0003654 0.67 rs9400016 103.36 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 6 0.0003864 0.69 rs9402666 136.02 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 6 1.54E-05 1.95 rs9402666 136.02 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 6 0.0001516 1.95 rs9402666 136.02 logistic GE:AGE:SEX Ml vs control (at entry) 6 0.0001541 1.95 rs9402666 136.02 logistic AGE:SEX Ml vs control (at entry) 6 0.0004162 1.95 rs943262 131.17 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 10 0.0004504 0.80 rs9443027 87.55 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.0001282 0.69 rs9443027 87.55 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 6 0.0002616 0.71

σ σ ^>>

rs9443027 87.55 logistic AGE:SEX Ml vs control (at entry) 6 0.0004531 0.69 rs945033 115.66 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 14 0.0002313 1.38 rs945033 115.66 logistic GE:AGE:SEX Ml vs control (follow-up) 14 0.0004703 1.38 rs9458363 166.39 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 6 0.0004323 1.32 rs9464431 78.09 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 6 0.0003687 1.44 rs9466145 37.65 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 6 0.0003452 0.74 rs947377 214.75 logistic Ml vs no Ml (follow-up) 1 1.18E-05 1.83 rs947377 214.75 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 1 1.46E-05 1.83 rs947377 214.75 logistic AGE:SEX Ml vs no Ml (follow-up) 1 2.13E-05 1.83 rs947377 214.75 logistic Ml vs no Ml (at entry) 1 2.38E-05 1.80 rs947377 214.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 1 2.72E-05 1.83 rs947377 214.75 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 1 3.71 E-05 1.83 rs947377 214.75 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 3.77E-05 1.80 rs947377 214.75 logistic AGE:SEX Ml vs no Ml (at entry) 1 3.88E-05 1.80 rs947377 214.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 5.07E-05 1.80 rs947377 214.75 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 6.90E-05 1.80 rs947377 214.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 1 0.000258 1.83 _w rs947377 214.75 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0004793 1.80

S; rs9481070 117.92 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.000169 2.44 rs9481070 117.92 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 6 0.0004796 2.17 rs948460 113.29 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 11 2.88E-06 0.76 rs948460 113.29 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 11 1.93E-05 0.79 rs948460 113.29 logistic GE:AGE:SEX Ml vs no Ml (at entry) 11 0.0002069 0.76 rs948460 113.29 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 11 0.0002804 0.81 rs948460 113.29 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 11 0.0003787 0.76 rs9487240 117.76 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 6 0.0004693 1.21 rs949229 41.58 logistic AGE:SEX Ml vs control (follow-up) 18 0.0003008 1.45 rs949229 41.58 logistic Ml vs control (follow-up) 18 0.0004388 1.45 rs949944 45.45 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 13 0.0001124 1.41 rs9502593 11.51 logistic Ml vs control (follow-up) 6 0.0003475 1.40 rs9502593 11.51 logistic AGE:SEX Ml vs control (follow-up) 6 0.0003814 1.40 rs9505351 13.67 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 6 0.0002432 1.25 rs951574 90.99 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 16 1.84E-05 0.48 rs951574 90.99 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 16 1.93E-05 0.50 rs951574 90.99 logistic AGE:SEX Ml vs no Ml (at entry) 16 2.20E-05 0.48 rs951574 90.99 logistic AGE:SEX Ml vs no Ml (follow-up) 16 2.32E-05 0.50

rs951574 90.99 logistic Ml vs no Ml (at entry) 16 2.57E-05 0.48 rs951574 90.99 logistic GE:AGE:SEX Ml vs no Ml (at entry) 16 2.74E-05 0.48 rs951574 90.99 logistic Ml vs no Ml (follow-up) 16 2.80E-05 0.50 rs951574 90.99 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 16 2.88E-05 0.50 rs951574 90.99 logistic Ml vs control (at entry) 16 7.30E-05 0.46 rs951574 90.99 logistic AGE:SEX Ml vs control (at entry) 16 9.52E-05 0.46 rs951574 90.99 logistic GE:AGE:CRCLSEX Ml vs control (at entry) 16 9.64E-05 0.46 rs951574 90.99 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 16 0.0001373 0.48 rs951574 90.99 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 16 0.000163 0.50 rs951574 90.99 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 16 0.0002515 0.48 rs951574 90.99 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 16 0.0002792 0.50 rs951574 90.99 logistic GE:AGE:SEX Ml vs control (at entry) 16 0.0003603 0.46 rs9519135 86.77 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 13 0.0004284 1.86 rs9519136 86.77 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 13 0.0001817 1.93 rs9519136 86.77 logistic Ml vs no Ml (at entry) 13 0.0003768 1.70 rs9519136 86.77 logistic AGE:SEX Ml vs no Ml (at entry) 13 0.0003807 1.70 rs9536485 45.45 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 13 8.13E-05 1.42 rs9542290 52.52 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 13 0.0004966 0.83 rs9548386 33.03 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 1.88E-05 0.42 rs9548386 33.03 logistic GE:AGE:SEX Ml vs no Ml (at entry) 13 2.81 E-05 0.42 rs9548386 33.03 logistic Ml vs no Ml (at entry) 13 2.96E-05 0.42 rs9548386 33.03 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 13 3.75E-05 0.42 rs9548386 33.03 logistic AGE:SEX Ml vs no Ml (at entry) 13 7.05E-05 0.42 rs9548386 33.03 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 13 0.0001009 0.42 rs9548386 33.03 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 13 0.0001695 0.48 rs9548386 33.03 logistic Ml vs no Ml (follow-up) 13 0.0001775 0.48 rs9548386 33.03 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 13 0.0002092 0.48 rs9548386 33.03 logistic GE:AGE:SEX Ml vs control (at entry) 13 0.0002722 0.43 rs9548386 33.03 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 13 0.0002733 0.48 rs9548386 33.03 logistic Ml vs control (at entry) 13 0.0003602 0.43 rs9548386 33.03 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 13 0.0003896 0.43 rs9548386 33.03 logistic AGE:SEX Ml vs no Ml (follow-up) 13 0.000484 0.48 rs9568927 45.46 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 13 0.0001987 1.36 rs9587525 97.42 logistic AGE:SEX Ml vs control (at entry) 13 3.96E-05 1.41 rs9587525 97.42 logistic Ml vs control (at entry) 13 0.0001078 1.41 rs9587525 97.42 logistic GE:AGE:SEX Ml vs control (at entry) 13 0.0001197 1.41

rs9587525 97.42 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 13 0.000124 1.41 rs9587525 97.42 logistic AGEiSEX Ml vs control (follow-up) 13 0.0003248 1.38 rs9587525 97.42 logistic AGE:SEX Ml vs no Ml (at entry) 13 0.0004465 1.26 rs9592445 50.41 logistic GE:AGE:SEX Ml vs control (at entry) 13 3.22E-05 0.69 rs9592445 50.41 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 13 4.26E-05 0.69 rs9592445 50.41 logistic AGE:SEX Ml vs control (at entry) 13 0.000208 0.69 rs9592445 50.41 logistic Ml vs control (at entry) 13 0.0002151 0.69 rs9592445 50.41 logistic GE:AGE:SEX Ml vs control (follow-up) 13 0.000298 0.70 rs9592445 50.41 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 13 0.0003581 0.70 rs963364 92.54 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 12 0.000353 0.70 rs9634125 17.04 logistic AGE:SEX Ml vs control (follow-up) 12 6.34E-06 0.39 rs9634125 17.04 logistic GE:AGE:SEX Ml vs control (follow-up) 12 1.23E-05 0.39 rs9634125 17.04 logistic Ml vs control (follow-up) 12 1.48E-05 0.39 rs9634125 17.04 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 12 1.54E-05 0.39 rs9634125 17.04 logistic AGEiSEX Ml vs control (at entry) 12 4.34E-05 0.43 rs9634125 17.04 logistic GE:AGE:SEX Ml vs control (at entry) 12 5.87E-05 0.43 rs9634125 17.04 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 12 7.98E-05 0.39 _w rs9634125 17.04 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 12 8.14E-05 0.43

S rs9634125 17.04 logistic Ml vs control (at entry) 12 8.87E-05 0.43 rs9643109 124.56 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 8 0.0001982 0.73 rs9643109 124.56 logistic GE:AGE:SEX Ml vs control (at entry) 8 0.000202 0.73 rs9643109 124.56 logistic AGE:SEX Ml vs control (at entry) 8 0.0003267 0.73 rs9643109 124.56 logistic Ml vs control (at entry) 8 0.0004095 0.73 rs9649972 147.69 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 8 0.0003147 0.72 rs9666878 66.11 logistic AGEiSEX Ml vs control (follow-up) 11 8.92E-05 1.42 rs9666878 66.11 logistic AGE:SEX Ml vs no Ml (at entry) 11 0.0002092 1.29 rs9666878 66.11 logistic Ml vs control (follow-up) 11 0.0003011 1.42 rs9666878 66.11 logistic AGE:SEX Ml vs control (at entry) 11 0.0003614 1.35 rs9666878 66.11 logistic Ml vs no Ml (at entry) 11 0.0004012 1.29 rs974542 72.64 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 13 0.0004501 1.33 rs974542 72.64 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 13 0.0004711 1.33 rs9770283 127.07 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 7 7.47E-05 1.32 rs9770283 127.07 logistic GE:AGE:SEX Ml vs no Ml (at entry) 7 9.37E-05 1.32 rs9770283 127.07 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 7 0.0001087 1.32 rs9770283 127.07 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 7 0.0001146 1.32 rs9770283 127.07 logistic Ml vs no Ml (at entry) 7 0.0001423 1.32

rs9770283 127.07 logistic AGE:SEX Ml vs no Ml (at entry) 7 0.0002477 1.32 rs9785216 66.21 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 9 1.64E-05 1.60 rs9785216 66.21 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 9 3.31 E-05 1.60 rs9785216 66.21 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 9 4.64E-05 1.60 rs9785216 66.21 logistic AGE:SEX Ml vs control (follow-up) 9 5.24E-05 1.60 rs9785216 66.21 logistic Ml vs control (follow-up) 9 9.23E-05 1.60 rs9785216 66.21 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0001058 1.60 rs980373 62.94 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 0.0003599 1.29 rs980373 62.94 logistic Ml vs control (follow-up) 18 0.0004457 1.44 rs980373 62.94 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0004634 1.29 rs9806846 42.54 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 16 4.91 E-05 0.68 rs9807505 9.27 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 3.82E-05 1.47 rs9807505 9.27 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0002248 1.40 rs9807505 9.27 logistic AGEiSEX Ml vs no Ml (at entry) 18 0.0004008 1.47 rs9807505 9.27 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0004983 1.47 rs982655 127.56 logistic AGEiSEX Ml vs control (at entry) 7 0.0003178 1.71 rs982655 127.56 logistic Ml vs control (at entry) 7 0.0004798 1.71 _w rs983249 36.17 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 6.67E-06 1.56

& rs983249 36.17 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 2.13E-05 1.56 rs983249 36.17 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 2.47E-05 1.52 rs983249 36.17 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 2.87E-05 1.56 rs983249 36.17 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 6.51 E-05 1.52 rs983249 36.17 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 8.67E-05 1.52 rs983249 36.17 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 9.79E-05 1.56 rs983249 36.17 logistic AGE:SEX Ml vs no Ml (at entry) 2 0.0001397 1.56 rs983249 36.17 logistic Ml vs no Ml (at entry) 2 0.0001986 1.56 rs983249 36.17 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 0.0002287 1.52 rs983249 36.17 logistic AGE:SEX Ml vs no Ml (follow-up) 2 0.0003089 1.52 rs983249 36.17 logistic Ml vs no Ml (follow-up) 2 0.000466 1.52 rs9843110 176.94 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 6.56E-05 1.30 rs9850420 107.42 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 1.01 E-06 0.13 rs9850420 107.42 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 1.29E-06 0.13 rs9850420 107.42 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 1.34E-06 0.13 rs9850420 107.42 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 1.36E-06 0.13 rs9850420 107.42 logistic Ml vs no Ml (at entry) 3 1.43E-06 0.13 rs9850420 107.42 logistic AGE:SEX Ml vs no Ml (at entry) 3 2.81 E-06 0.13

rs9850420 107.42 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 6.20E-06 0.24 rs9850420 107.42 logistic Ml vs no Ml (follow-up) 3 6.38E-06 0.24 rs9850420 107.42 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 8.43E-06 0.24 rs9850420 107.42 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 1.03E-05 0.24 rs9850420 107.42 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 1.52E-05 0.24 rs9850420 107.42 logistic AGE:SEX Ml vs no Ml (follow-up) 3 1.75E-05 0.24 rs9850420 107.42 logistic GE:AGE:SEX Ml vs control (at entry) 3 3.46E-05 0.17 rs9850420 107.42 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 3 5.25E-05 0.17 rs9850420 107.42 logistic Ml vs control (at entry) 3 7.32E-05 0.17 rs9850420 107.42 logistic AGE:SEX Ml vs control (at entry) 3 9.53E-05 0.17 rs9851591 64.16 logistic Ml vs control (at entry) 3 0.0002185 0.43 rs9851591 64.16 logistic AGE:SEX Ml vs control (at entry) 3 0.00027 0.43 rs9854717 76.95 logistic AGE:SEX Ml vs no Ml (follow-up) 3 2.88E-05 1.43 rs9854717 76.95 logistic Ml vs no Ml (follow-up) 3 3.27E-05 1.43 rs9854717 76.95 logistic AGE:SEX Ml vs no Ml (at entry) 3 3.50E-05 1.43 rs9854717 76.95 logistic Ml vs no Ml (at entry) 3 3.85E-05 1.43 rs9854717 76.95 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 7.35E-05 1.43 rs9854717 76.95 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 9.12E-05 1.43

4- rs9854717 76.95 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0001023 1.43 rs9854717 76.95 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0001266 1.43 rs9854717 76.95 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0001621 1.43 rs9854717 76.95 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0002176 1.43 rs9854717 76.95 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 0.0002442 1.43 rs9854717 76.95 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0004845 1.43 rs9871763 83.22 logistic GE:AGE:ACR:SEX Ml vs control (follow-up) 3 8.93E-05 0.70 rs987280 95.07 logistic AGE:SEX Ml vs control (at entry) 5 0.0002657 0.75 rs9876535 21.77 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 3 4.66E-05 1.44 rs9876535 21.77 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 7.89E-05 1.51 rs9876535 21.77 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0002023 1.46 rs9876535 21.77 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0003071 1.51 rs9876535 21.77 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 3 0.0003206 1.41 rs9876535 21.77 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 0.0003535 1.51 rs9876535 21.77 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 0.0003572 1.51 rs988213 66.78 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 18 0.0001619 0.82 rs988292 19.66 logistic AGE:SEX Ml vs control (at entry) 21 3.72E-05 1.43 rs988292 19.66 logistic Ml vs control (at entry) 21 5.63E-05 1.43

rs988292 19.66 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 21 0.0001149 1.43 rs988292 19.66 logistic AGE:SEX Ml vs no Ml (follow-up) 21 0.0001165 1.30 rs988292 19.66 logistic Ml vs no Ml (follow-up) 21 0.0001648 1.30 rs988292 19.66 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 21 0.00018 1.30 rs988292 19.66 logistic GE:AGE:SEX Ml vs control (at entry) 21 0.000195 1.43 rs988292 19.66 logistic AGE:SEX Ml vs no Ml (at entry) 21 0.0002801 1.29 rs988292 19.66 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 21 0.0002826 1.30 rs988292 19.66 logistic Ml vs no Ml (at entry) 21 0.000366 1.29 rs988292 19.66 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 21 0.0004085 1.30 rs988292 19.66 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 21 0.0004111 1.43 rs988292 19.66 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 21 0.0004251 1.29 rs9906088 53.54 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 17 2.25E-05 1.36 rs9906088 53.54 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 17 7.14E-05 1.33 rs9910530 81.57 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 17 0.0003234 1.28 rs993422 91.99 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0001551 0.78 rs993422 91.99 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 5 0.0002219 0.78 rs993422 91.99 logistic AGE:SEX Ml vs no Ml (follow-up) 5 0.000309 0.78 rs993422 91.99 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 5 0.0003178 0.78

Ul

O rs993422 91.99 logistic Ml vs no Ml (follow-up) 5 0.0003522 0.78 rs9939736 125.75 logistic HBP:GE:AGE:SEX Ml vs control (follow-up) 16 5.58E-05 0.68 rs9939736 125.75 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 16 0.0002245 0.74 rs9939736 125.75 logistic GE:AGE:SEX Ml vs control (follow-up) 16 0.0002289 0.68 rs9939736 125.75 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 16 0.0003882 0.68 rs9939910 98.98 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 16 0.0002932 1.78 rs9944695 51.64 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0001836 0.47 rs9944695 51.64 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0002041 0.47 rs994556 76.94 logistic AGEiSEX Ml vs no Ml (at entry) 3 3.99E-06 1.48 rs994556 76.94 logistic Ml vs no Ml (at entry) 3 5.54E-06 1.48 rs994556 76.94 logistic AGE:SEX Ml vs no Ml (follow-up) 3 6.88E-06 1.46 rs994556 76.94 logistic Ml vs no Ml (follow-up) 3 1.01 E-05 1.46 rs994556 76.94 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 3 1.52E-05 1.48 rs994556 76.94 logistic GE:AGE:SEX Ml vs no Ml (at entry) 3 2.01 E-05 1.48 rs994556 76.94 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 3 2.12E-05 1.46 rs994556 76.94 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 2.76E-05 1.46 rs994556 76.94 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 3 8.94E-05 1.48 rs994556 76.94 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 0.0001261 1.46

rs994556 76.94 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0001292 1.46 rs994556 76.94 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 3 0.0001384 1.48 rs9948698 10.40 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0002442 1.33 rs9948698 10.40 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.000325 1.25 rs9948698 10.40 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0003642 1.25 rs9948698 10.40 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0003735 1.33 rs9948698 10.40 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0004479 1.25 rs9951521 10.31 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0003231 1.33 rs9951521 10.31 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0004574 1.24 rs9951521 10.31 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.0004745 1.24 rs995401 130.99 logistic Ml vs no Ml (follow-up) 4 0.0003268 1.34 rs995401 130.99 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0003619 1.34 rs995401 130.99 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0004906 1.34 rs9956997 41.69 logistic AGE:SEX Ml vs control (follow-up) 18 0.0002778 1.44 rs9956997 41.69 logistic Ml vs control (follow-up) 18 0.0004326 1.44 rs9958524 63.55 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0003747 1.43 rs9958524 63.55 logistic AGE:SEX Ml vs control (at entry) 18 0.0004513 1.43 _w rs9958524 63.55 logistic Ml vs control (at entry) 18 0.0004528 1.43

2 rs9965071 10.39 logistic GE:AGE:SEX Ml vs control (at entry) 18 0.0002384 1.33 rs9965071 10.39 logistic GE:AGE:SEX Ml vs no Ml (at entry) 18 0.0003501 1.25 rs9965071 10.39 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 18 0.0003625 1.33 rs9965071 10.39 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 18 0.000388 1.25 rs9965071 10.39 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 18 0.0004833 1.25 rs9965472 52.75 logistic AGE:SEX Ml vs control (follow-up) 18 0.0001831 0.66 rs9965472 52.75 logistic Ml vs control (follow-up) 18 0.0002313 0.66 rs9965472 52.75 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 18 0.00031 0.66 rs9965472 52.75 logistic AGE:SEX Ml vs no Ml (follow-up) 18 0.0003299 0.74 rs9965472 52.75 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 0.0004076 0.74 rs9965472 52.75 logistic Ml vs no Ml (follow-up) 18 0.0004113 0.74 rs9965472 52.75 logistic AGE:SEX Ml vs control (at entry) 18 0.0004273 0.69 rs9965472 52.75 logistic Ml vs control (at entry) 18 0.0004332 0.69 rs9965472 52.75 logistic GE:AGE:SEX Ml vs control (follow-up) 18 0.0004814 0.66 rs9965472 52.75 logistic AGE:SEX Ml vs no Ml (at entry) 18 0.0004952 0.74 rs9966194 82.77 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 18 0.0003958 1.27 rs9966194 82.77 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 18 0.0004185 1.27 rs9968025 29.83 logistic Ml vs no Ml (at entry) 22 0.0002458 0.49

rs9968025 29.83 logistic GE:AGE:SEX Ml vs no Ml (at entry) 22 0.0003356 0.49 rs9968025 29.83 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 22 0.0004503 0.49 rs996967 73.18 logistic GE:AGE:SEX Ml vs no Ml (at entry) 4 6.89E-06 0.36 rs996967 73.18 logistic Ml vs no Ml (at entry) 4 8.95E-06 0.36 rs996967 73.18 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 4 1.08E-05 0.36 rs996967 73.18 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 1.08E-05 0.36 rs996967 73.18 logistic AGEiSEX Ml vs no Ml (at entry) 4 1.99E-05 0.36 rs996967 73.18 logistic GE:AGE:SEX Ml vs control (at entry) 4 2.04E-05 0.38 rs996967 73.18 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 4 4.37E-05 0.38 rs996967 73.18 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 4 4.66E-05 0.36 rs996967 73.18 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 8.89E-05 0.44 rs996967 73.18 logistic Ml vs no Ml (follow-up) 4 9.04E-05 0.44 rs996967 73.18 logistic Ml vs control (at entry) 4 0.0001205 0.38 rs996967 73.18 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0001341 0.44 rs996967 73.18 logistic AGE:SEX Ml vs control (at entry) 4 0.0001488 0.38 rs996967 73.18 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0001523 0.44 rs996967 73.18 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0002285 0.44 rs9971144 103.73 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 10 0.0003353 1.16

Ul K> rs9973427 187.26 logistic GE:AGE:SEX Ml vs no Ml (at entry) 2 2.29E-06 0.14 rs9973427 187.26 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 2 2.78E-06 0.14 rs9973427 187.26 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 2 3.12E-06 0.14 rs9973427 187.26 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 2 3.20E-06 0.14 rs9973427 187.26 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 2 4.32E-06 0.20 rs9973427 187.26 logistic Ml vs no Ml (at entry) 2 4.44E-06 0.14 rs9973427 187.26 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 2 5.49E-06 0.20 rs9973427 187.26 logistic Ml vs no Ml (follow-up) 2 6.96E-06 0.20 rs9973427 187.26 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 2 7.06E-06 0.20 rs9973427 187.26 logistic AGE:SEX Ml vs no Ml (at entry) 2 7.17E-06 0.14 rs9973427 187.26 logistic HBP:GE:AGE:SEX Ml vs no Ml (follow-up) 2 8.16E-06 0.20 rs9973427 187.26 logistic AGE:SEX Ml vs no Ml (follow-up) 2 1.37E-05 0.20 rs9973427 187.26 logistic GE:AGE:SEX Ml vs control (at entry) 2 7.85E-05 0.18 rs9973427 187.26 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 2 0.0001159 0.18 rs9973427 187.26 logistic Ml vs control (at entry) 2 0.0001681 0.18 rs9973427 187.26 logistic AGE:SEX Ml vs control (at entry) 2 0.0001771 0.18 rs9973427 187.26 logistic GE:AGE:SEX Ml vs control (follow-up) 2 0.0004833 0.26 rs9977697 54.94 logistic Ml vs control (follow-up) 21 0.0004425 0.70

rs9981939 48.21 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 21 0.0002708 0.74 rs998564 100.02 logistic Ml vs no Ml (follow-up) 14 0.0003211 0.78 rs998564 100.02 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 14 0.0003692 0.78 rs998564 100.02 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 14 0.0004079 0.78 rs999938 52.26 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 7 0.0003211 1.23 rs5018999 116.87 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.00028 1.35 rs5018999 116.87 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0002966 1.35 rs5018999 116.87 logistic Ml vs no Ml (follow-up) 4 0.0003522 1.35 rs5018999 116.87 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 4 0.0004498 1.35 rs5018999 116.87 logistic GE:AGE:CRCL:SEX Ml vs no Ml (follow-up) 4 0.0004813 1.35 rs2862907 10.34 logistic GE:AGE:CRCL:SEX Ml vs control (follow-up) 13 0.0003536 1.47 rs2862907 10.34 logistic GE:AGE:SEX Ml vs control (follow-up) 13 0.0003642 1.47 rs41339546 50.30 logistic Ml vs no Ml (at entry) 7 4.79E-05 0.39 rs41339546 50.30 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 7 7.00E-05 0.39 rs41339546 50.30 logistic GE:AGE:SEX Ml vs no Ml (at entry) 7 7.11 E-05 0.39 rs41339546 50.30 logistic AGE:SEX Ml vs no Ml (at entry) 7 8.84E-05 0.39 rs41339546 50.30 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 7 0.0001454 0.39 rs41339546 50.30 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 7 0.0004618 0.39

Ul rs41423448 115.71 logistic HBP:GE:AGE:SEX Ml vs no Ml (at entry) 1 5.79E-05 0.43 rs41423448 115.71 logistic GE:AGE:SEX Ml vs no Ml (at entry) 1 0.0001161 0.43 rs41423448 115.71 logistic GE:AGE:CRCL:SEX Ml vs no Ml (at entry) 1 0.0001527 0.43 rs41423448 115.71 logistic Ml vs no Ml (at entry) 1 0.0001762 0.43 rs41423448 115.71 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 1 0.0001778 0.43 rs41423448 115.71 logistic AGE:SEX Ml vs no Ml (at entry) 1 0.0003408 0.43 rs41507953 54.23 logistic HBP:GE:AGE:SEX Ml vs control (at entry) 8 0.0004843 0.63 rs41446549 37.21 logistic GE:AGE:ACR:SEX Ml vs control (at entry) 15 0.0003062 0.65 rs41446549 37.21 logistic GE:AGE:SEX Ml vs control (at entry) 15 0.0003514 0.65 rs41446549 37.21 logistic GE:AGE:CRCL:SEX Ml vs control (at entry) 15 0.000489 0.65 rs41334345 57.88 logistic AGE:SEX Ml vs control (at entry) 4 6.02E-05 0.68 rs41334345 57.88 logistic Ml vs control (at entry) 4 7.17E-05 0.68 rs41334345 57.88 logistic AGE:SEX Ml vs no Ml (at entry) 4 0.0001353 0.74 rs41334345 57.88 logistic Ml vs no Ml (at entry) 4 0.0001453 0.74 rs41334345 57.88 logistic AGE:SEX Ml vs no Ml (follow-up) 4 0.0001484 0.74 rs41334345 57.88 logistic Ml vs no Ml (follow-up) 4 0.0001645 0.74 rs41334345 57.88 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 4 0.0003659 0.74 rs41334345 57.88 logistic GE:AGE:ACR:SEX Ml vs no Ml (at entry) 4 0.0003776 0.74

rs41391845 71.88 logistic WII vs control (follow-up) 9 0.0001468 1.84 rs41391845 71.88 logistic AGE:SEX Ml vs control (follow-up) 9 0.0003191 1.84 rs41391845 71.88 logistic GE:AGE:SEX Ml vs control (follow-up) 9 0.0004401 1.84 rs41342346 0.34 logistic GE:AGE:ACR:SEX Ml vs no Ml (follow-up) 3 0.0002137 1.94 rs41342346 0.34 logistic Ml vs no Ml (follow-up) 3 0.0004428 1.94 rs41342346 0.34 logistic GE:AGE:SEX Ml vs no Ml (follow-up) 3 0.0004662 1.94 rs2581365 114.57 logistic Ml vs control (follow-up) 15 0.0001457 0.69 rs2581365 114.57 logistic AGE:SEX Ml vs control (follow-up) 15 0.0004757 0.69

Ul

Table 5 dbSNP RS ID Flank rsl0008134 AGCrGAGGCTTTTAGA[CZT]GTAGATTAGGTTGGTG rsl0016434 GATGTATATTATCTCAIA/GIAGACTTACTAGTTTAG rsl0019443 AGGCGGAGGAAGACAA[A/G]GAGTGGTATCATGGAA rsl0025924 TATTAAACTGAATGTC[A/G]CAGGTAATTGTAACAC rsl0030781 TACTATTACTGTTTAA[C/T]AAAGTACACCATAACT rsl003499 TAAGTAATCACTTGTG[C/T]AATGGCTGCGG ACGCC rsl0040756 TG G ATTTTCAG ACCAG [A/G] CTG AGCTG AAGTTTTT rsl0045924 CCACAACCACATGATA[CZT]CACCTCTCAGAGTCCT rsl0055448 TTTGGAGCTAAATGAA[A/G]GGTTCTGAGGCTGGCA rsl0055823 TCCTCAGTTGTGATAC[A/G]GGAGTCATGAAAGTAA rsl0056728 CATCACATTCTGGTGT[C/T]AAACTTTAAGCAGTCA rsl0059571 CCTGACTTACCAATGC[A/G]AGATCACCCCGAGAAG rslOO61288 TCCCTCAGAGATGAAA[AZG]GAGAGGGGAAGGAAAA rsl0071774 AGGGCCTTATGTGTTA[C/T]GTTAAGCACCAGGAAC rsl0073800 TTTGGAATTATAGGCC[C/T]GAACATTCTCGTGAAC rsl0077201 AGTCAGGGCAGTGGTCIA/GIACTATTAAAAAAATTA rslOO77522 ATCAGGTCATCTGGAC[AZG]AATCTTGAAACACATT rslOO79167 AGAGAAATCTGTGAGAtA/GlGATTGGAAGGCAGAAG rsl0081428 AGCATGTAACGCTGGA[CZT]GGATGTAATGCCTAGA rsl0081556 TTTTAAGTGAAAGATG [AZG]AATATCCCAAATGTAT rslOO82865 GGGAAAAGAGGGCCAA[CZG]TAGACACACCCAGGAA rsl0105587 ATAAACAAGCTGTTCC[AZG]ACTTTTGAACAAATCC rsl0106008 GTAGGAGTTTGCAAGA[AZG]AGTAGTTCTGAAGATC rsl0106681 ACTAGAGTGATGTTTC[CZT]AGAGGCCCAGGAACAT rsl0108241 AGTGTACATGGTTTCA[CZT]GATTATAGCTCGTTTT rsl0111251 TGGAAAGTGTGATGAA[AZC]TCTATAAAGCAGGGTA rslO112761 GGCTTTTACTGTGACA[AZG]TCACTCAAATAGTGTA rslO116672 TGAGGCAGCACTCTAG[AZT]AAGGA I I I I IAACTGC rsl0121700 AGTTTGATAATGTAAA[CZT]TGGGGAAAGTGAGTAT rsl0128270 TTGGACATTTGCACAA[GZT]AATTAACTTTACCAAT rsl0140164 TATTCACTTGTTCTCC[AZG]AAATAAATCTGTAAAG rslO14744 AAGAGATGCTGACTCC[AZG]AAATGTAAAATAACCC rslO14994 ACCTGTAAACAGACCT[CZG]AAAACATAGTGTTCAC rslO153433 ACTGAATTTATGCTGA[CZT]GTGACTATAATCTTCA rslO159959 ACATmTAAAGTAGA[AZG]TAACGCAATATTAATA rslO161196 TACAGGCAAATGAGAG[AZG]CTATTACTCACCACAA rsl0161200 ATAATACCAGCATCCA[CZG]AGTCAATTGTGTTCCA rslO161233 GGACTGGATAGGAGAA[GZT]GTAGCTCGGAGAAAGT rsl0161338 CTGGCCCATTGAGACA[AZG]TCAAAACTGATTAATT rslO17213 CACTGTGTAAGCAAGA[CZT]CAGGTTAGTTCTCTCA rslO183453 AAAAAATCCAATTTTG[AZG]ACATGAAAATATATGC rsl0186075 GTAACATTGCTAGTGA[AZG]TACACATTTTAGAAGG rslO19219 CTGAATAATTTTGATC[AZG]ACAGCTGCACTGTCAA rsl0193182 CAGCCCCAGGTTCTCC[AZG]GCTAATGGGATTCCAG

rsl0195506 ATGTATTGAGAGCCTA[C/T]CATTTTCTAGAACCCA rslO21O369 CAATGATTTTGGGACA[C/T]GTGAAAATGCTTTTAC rsl0211389 TCAGAAATGCTTTGGA[C/T]GAGACGTATTTTGCAT rslO22242O CCCAGGTATAGCAATA[G/T]AAACGCTACAGAAGCT rslO24654 GTTGATAGAATCCAGA[CZG]AAGATAAAAAGAAGAT rsl0281059 CTTTCCTCAGGTTAAA[C/G]AAGAAATCAGTTCTGA rsl028932 TCCTCCTACATGATTA[C/G]CAGGTTTGAATTπTG rsl036515 AGAAAGTAGTCAGATA[C/T]GCTAAGTTCTCAGCCA rsl040404 ACTATTTTCTACCACA[C/T]CTAATTTCACTACAAA rsl0426996 TCAGAAGTGCTTAAAG[GZT]ATATGAACAGATATTT rsl0439056 TGGCAGCCAGTGATCT[C/T]ACCTAGATGAGGTCTG rslO471462 ATCCCTGCAAGACCAT[C/T]AATGTAATGAACAGAA rsl0474222 AAGTTTCTTCAAAGGA[GZT]TAGGCATTTATAAGTT rslO474312 GCTGCCTGGACTGTTA[C/T]ATTAGGAAGGATTGTG rsl0484338 GTTAACTGCTAGAAGA[CZT]GGCAGCAGATGACACT rslO485214 TCTTTGGTGGTATTGA[AZT]GAGAAGGAAACTCTAT rsl0488899 GTGGACTGATGGTTCA[A/C]CATAAAATACTTGCAG rsl0489434 TTATGTATGATCTACA[AZG]AAAATAACCGTTTGAC rsl0493090 CTCTCAGTGGCCTACG[A/C]ATCGCCAGTCCTGACA rslO497186 TGTTTTGAGATTCAAA[C/T]GTAACACAGGGAATAG rslO5O1798 GCATCTTCGACATCCA[C/T]CAATTTGGTACCACAG rsl0503813 GGGGTTCAGTCACTCA[C/G]AGATTCCACCTGGGTG rsl0504841 GATATGAGAAGAGATC[A/G]ACTCATTTACATCTTG rsl0504880 CTTCCTTCTCTATCCA[C/T]TCACTGGCTGTTGTGG rsl0505346 CTAGGGTGTCCTTTTA[A/C]GCTGCAAAGTTCCTGC rsl0505349 GTACTCTAGATTCTCT[C/G]AAAAATCCCATGGTTC rsl0509812 AGTTGGCAATTCTGAC[C/G]GACTGTTGTCTGGGAG rslO51O115 ATTTTAAACGGTAAGA[G/T]AATTTTCATACACACA rsl0510650 ACTTTCGTTCCTTCCA[CZT]TCCACCAAACTTGATG rslO511782 AATTATTATTGCTTCAIA/GIAAACTTTTATCTTAGA rsl0512942 CTTTACTGTTGCTAAC[G/T]GAAGGAATTGAGGTAT rsl0514064 TAAATTAGCATAAATC[AZT]ATAAGGAGGTCAAAGC rslO514925 ACGTAGGACGCCGGCA[CZG]AGAAGGAGCCGGGTGG rsl0519051 AATAGTCATAGCAGAAlA/GlTAATACTGATAATATT rsl0519085 TGAAAACTGCCTTATC[A/G]ATGTAAGTGGTTGGGT rsl0734480 TCATTTCTGTAGGCAA[C/T]TCTGTCACACTGTTGT rsl0738885 AGAAGACAGGATCTGA[C/T]GGGCTAAGTATCTTGC rslO741552 AGAGGAAATGATGTGC[AZG]AATGAGAAAATTTTAA rslO74156 AACTCCTCAAAAGAAT[G/T]AAGGCGGAACATGACA rsl0743478 TTTCAATTATGCTCCA[C/T]TGACATAACAGCTGTT rsl0743879 AAATAAAACAGATATC[A/C]AAAATTTCTTACACAC rsl0745995 TAAATAGGTGCCCAAA[A/G]CAAATCTGTTGAATGA rsl0745996 AAATGATCTTAAAGAA[C/T]GAGGTTGTGCCTTACT rsl0746342 TCTTTGACACAGGCTT[A/T]AAAAAAATAAAGAAAG rslO75O359 TGGACTTGGAGATGGAlG/ηAGTGAGTACACGGAGA rsl0755926 CAATTAAATTGTTACAIA/GITCACTTCACTGGGCCA rslO759217 ATGGCACGGGGAAAGA[CZG]AGAATGACTCAAACAT

rslO76O333 TATAATCTCAAGCAAA[A/G]CATCTGGTGCCTCAGT rsl0765565 ACCTGGACACACAACA[A/C]GTATTCCAGAGACTCT rsl0772017 TGTGTGGTTACTTCAA[C/T]ATCCTGTCATACCAGT rsl0774703 AAGCATATTCTCAGGC[C/T]CTACCTCAAACCTACA rsl0774703 AAGCATATTCTCAGGC[C/T]CTACCTCAAACCTACA rslO77861 GAAGGGGCATTTCTGA[A/T]TAAGATCTGGGCCGCT rsl0778928 GAGTGAGACCAAAATA[C/T]GGAGCAAATCAACATA rsl0779158 GTTGCCTGTAAGCCTAIA/GJGTTTGCTTGTTCTTTC rsl0780685 TAATCG ATCAG AG ATG [C/G] AAGCAGTTCAAATTGT rsl0793682 ATTCTATTAATGAGAAIA/CJGTGTGAAGTAGGAGAC rsl0801047 CTTAAATTCAAATTTA[A/T]CTCTGCTGTGTATTTT rsl0802580 ACATTCCAGCATGGAG[C/T]CAAGACTGCTCGTGAC rsl0808479 TCTATTTTGCATGAAAlA/GlAAAAAGAGTCGTAGTT rsl0809509 CAAAATAAAAGGTGTA[G/T]AGCAATTTCAGCGGAT rslO815384 TGTGTCTAGCCTTTAA[C/T]AGTCACTTAATAAAGG rslO815385 TTTGACCATACCTAGT[C/T]AAACTTAAATTGAAGG rslO815386 ATTTTCCTTTAACATC[A/C]GATATTGGCAGCCAGC rslO815387 CATCAG ATATTGGCAG[C/T]CAGCTTTTCCAGATTT rslO82342O CTGAGAATAAGAGGAAIC/GlAGAAGATATGAGGGTG rsl0824378 GATGGCCATTTCTCCA[A/G]TGAAGTTTCCTGTAGC rslO824541 GATTTATATCCCAGCT[C/G]AACCTCTTATAACTGT rsl0825228 TGTCTATAGTTTCCCA[C/G]GCATTACTAACTCATG rsl0827750 GAAATAGCCTTACAAC[A/G]CTGTGAATTCAATCCT rslO82866O TCTGCCAGAGAAAGTC[C/G]AAAATCTGTAAAGGAA rsl0836005 TGGTGGGACTGTCAAC[A/G]AGTTCATCCATTGTGG rsl0836533 CAATACAAGAAAAGGA[A/C]GAAGAAGTTCACACCT rslO83662O TATTTGCCAAAGCCCA[A/T]GTCGAGAAGGGAAATT rslO839816 CTTGCCTTGGGATCCT[A/C]AAAATGCATCTGCCTT rslO841292 ACAATCTCAGCCTGTT[A/G]AAATTGCCTGAGTTTT rsl0842643 AGCTACTTGGGAACTA[C/T]GACTGTACTACTGTAC rsl0845552 GAAAGTCTGAGGCAAT[C/T]ATAGAAACATCAGCCC rsl0850169 CCCCAGGTAATCCCAA[C/T]GTGAGCCTGGGCTATG rsl0850913 CGTGCCGG ATACCTAG [A/G]AGGCCACATTCCACAG rslO851378 AATAACATCCTTTGTC[C/T]CTGAACCAAGTTTCAT rslO86O982 TAACAGTTGTTTCTCAIC/GlAGGTATAATTCAAACT rslO861935 CCGTTTACTAGTTTGA[C/T]AGTGATTGCCAAATTG rslO868271 CAATTGTGATTGATGC[A/G]AGTAGCACCCTTCTGC rslO877125 TTTTTATCATTCCAAA[A/G]AGAGGAAATAAACCAA rsl0880791 AAGATCACATGTGTTA[C/T]ACCTTAACGAAAAACT rslO884261 GAACTGGGAAACTGTC[C/T]ATCATAATGGCACCAG rsl0885336 CTACTGTCATTTCTAC[C/T]GGGCAGCTGAGACCTT rsl0885337 GCTGTATTCCGTATCA[C/G]ACAACAACAGTTGAGG rsl0893649 GAAACTGCAATGTAAA[A/G]TTATGGTCACAAAGCA rsl0896380 AGGGAGTGCTGCTGAA[C/T]GGACTCCAGGAGGCGG rsl0898982 CAGTTTCTATGGGTTA[A/G]GAATTCAGAAAGGGCA rsl0901545 AAAAAAATAGCTAATAfC/TjGTTGAGGAGGAGGGAG rsl0923477 CAGGGTCAAATTACTA[C/T]CTGTATCCTTCTGATG

rsl0941073 CCTGCCCATAATAAAC[A/C]CATCCAGAAGAGACCC rsl0942230 GCTATTAAGTGGGTAA[C/T]AGGATGGACAATTCTT rsl0951655 TAGCATCTAACATAAGIA/CJCTAGATTCAGCATATA rsl0952398 TTTGATTAACAAGACTfA/TlACAAATTTGGTATAAT rsl0952429 GGCTGAGATGACCCAA[A/G]ACCTGCAATTGGAAAG rsl0955953 AGGCAGACTGAATTGA[C/T]GTTTAGGCAGCAAGCC rsl0956801 GTTTTGTGGTTAAAGG[A/G]ACATGTTAGAGGAAAT rsl0959548 CCTCTGAGTCCGATAA[C/T]TAAGAAGAGTGACCAT rsl0960001 AGTAGAACCACCTTAC[C/T]ACCTGAAGTTGCAGAG rsl0960002 TGTATACACTAAAGGC[C/T]CCCCTCAGTCTTAAAT rslO964178 CAATGCCAGAGTGAAC[A/G]ACCTCTAATGTTCTCT rsl0968433 TAG CAG CTC AT AC AAG [C/G] ATAG GTG ATATC ACAA rsl0968434 ATCAATAGCAGATTCA[A/G]CTTGCCTTTACCATGT rsl0972699 TATCCCCTTCCTGCCG [A/C] ATGACTAAAACTAAAT rsl0977348 TTTTCTACCAATCATG [A/G] ACCTTTTCTTTGAATA rsl0978784 GTATCTCACATCTGCT[C/T]AGAGCCCACGCCGCTA rsl0978835 AAGAATAACTGTATCAIA/GJTCAGGGTAAGTCTAGG rsl0980446 AGAGCTATCATAAACCIA/GJATGACCAAAATCATGC rsl0980452 GAGTTGTTGTTTAGCAtC/TlGAATGTTGTTACAATG rsl0982428 TGTGTACAATGTTTAAIC/TIAAGAGAGAAAGTTTTA rsl0989294 AAACTGTGGCTCCTTT[A/G]AAAGAATAGTTTCTGA rsl0991736 AGTATGGACATAGGAAIA/GJAGATGCAAGCAAACTG rslO991781 GCCATGAGGCCCCCCA[A/G]ATTCACCTGGAGAGCC rsl0996473 GTTGGTCTAGATCCAA[A/G]TACAGCATTTCTTAAA rsl0998910 GATGAAAGAGGCACCAIC/TITGGAATTTACAGCCCA rsll001683 CAAAGAACCATCCAAC[C/T]GAGTCCAAACTGCCAA rsll010237 GGGCAGGTGGACTCTG[C/T]CAATACCCTGGATGTG rsllO14137 ATGCTGTAAACTGTGA[C/T]GTCTATGAATATCTGA rsll018633 TATGCTTGCAAGTGGAfA/TlAAATAGGGTACAGAAA rsll020082 CTGGCTCTGTCATTGA[C/G]TAGCTCTGTAGCTCTG rsll020878 AGGAAAATATTCACCC[A/G]CTTAGCACAACCCATG rsllO44739 CATCATTTCTATCCTG [A/T] AG AAGCCTGACACTG A rsl 1044750 AGAGAGTCCCTACTAA[C/T]GAGAAAGCCCTCACCA rsllO47424 TCAGAAACAGATTGGA[C/T]GCπTAAAAAATTCCA rsll050429 TCTCTGTGGCATCTGC[A/G]CGGTAATAAAATTTAA rsllO54588 GAGAGTTCTGCCAGAA[A/G]CTAAGTTCATTCAAAG rsllO54878 TATGTATAACCTTGAA[C/G]TGTGAAGGCCAGGATC rsllO55699 AAGGGGACAAGGTAGA[C/T]GTGCATGAGGTCCCTT rsll060924 CCCCCTGGATGTGCAA[G/T]TTATCTGTACAGCAAA rsll065172 TCTGGGTTCAAATTCA[A/G]GTTGTCCTCTGCCCCT rsllO6662O AGCTGACCAGAGTGGG[A/G]AGTCAGAAGTCTCCAT rsllO66633 TGTCAGGTCTGCACGAIA/GJGATCTAGGAATACAGC rsllO66737 GCTCTCTCCAAGGACC[A/G]ACAGGATCGCTCTGCC rsllO66945 GGTACTTTTGTAAAGG [C/T]ATTTGATATGGTTTGT rsllO67O3O AGCAGATTGGAGGCAC[A/G]GTCTTGTACCAACAAA rsllO67311 AGTTTGAGGCTACAGT[C/T]ACTAATGATTGCCCCA rsllO71957 GTGCTTAGAAGTTCAA[C/T]GGAAAAGCATCTGGAA

rsllO79384 TTTTGAATAGTTATCA[C/T]GT6CATACAGTAAAGC rsll087179 AATGGATCTGTACAAA[C/T]GAACCTACTAAAATAA rsllO97731 AAGGCATTCCATTTTG[G/T]ATAGGATAGCTAATGC rslllO3567 AATAGCCAGTTAGCAG[G/T]CCTCAGAGCTTCTCTG rslllO6325 TATCAATTGTTTCAAA[C/T]GCACTAAAGTAAATAG rslllO8755 AATTTGACTTTCAATAlA/ηGATTTTGGTATAAAGG rslll09070 AGGTGTTATCTTCTCC[A/G]CTTAGAATGATTCCTC rslllll522 TAAAAATGATCTCCAA[A/G]GTCTTCTCCAATTTTA rslllll535 TGATGGGGAATTAGCC[C/T]AAGACTAACTGCTTCT rsllll5007 TATCTAACATTTTCCC[A/T]CCTGGTCTTGACCTAT rslll25644 CTATTTGAAGGTGAGAIA/GJAGGAGTGGACAATATA rslll3323 CCATCACAACATTCAT[C/G]TCCTCTGAGTCCAGGT rslll35724 TCTGTTAACGTACCAT[A/G]ATCTGTGCTTCGCTCG rslll42750 TTAAATGAATGTCCCA[A/C]ATAAAGTCACATGAGC rslll52968 TGGTTGTAGACATTAC[A/G]CAGCACCATTGTTAGT rslll53023 GAGTGAGATACATGAAIC/TJTCCAAATATCTGAGAC rslll53166 GGCTTTACATCTTACC[C/T]GCTTGACTAAGCTACA rslll53167 TCACCAGTATGTAAAA[A/T]CCTTGCAAATTCTGAC rslll57107 TAAAAAAAGCAGAGTG[C/T]ACAAGGAGGTCAAGTT rslll60288 TTGAAGTTAGGCTTTG[A/C]AGAGCCCTGGATTTTG rslll60289 AGCCTAACTTCAACTC[A/G]CCTGCCCAACCTTACC rslll63592 GAACTTCAAAATTCCA[A/G]GGTGCAAATATATTGT rslll67 TCATAGGATAAACAAAIC/TJAGCAAATGTACAGCCT rslll70242 AGTGGAAGAGAATGAAIC/TJTCGGTGGAGAGAGAGA rslll7702 TCCCGGAAGA I I I I I C[A/G]CTAACTTTGCCCACAT rslll83154 CATGTCCAAATG ACTA[C/T]CTACAGTTCAAACTGC rslll89836 TATGTTCTCTACAGTqA/GjAATTAAATGAAGAAGA rslll92739 CCTGGGCAGAGGATAGIG/TJATGAAAGTCAGCACTA rslll95125 AAAAAACATCAGAGGA[A/G]GTATGAGCATTGTTTC rslll95917 CCTTCCAAGGCTGTTC[A/G]AAATACCAAATACAAA rslll97169 TTAACATCGAAACATG[G/T]AAGTCTCAGTTACACA rsll208923 TTAAAGAAGATGGTCA[C/T]GAAATAGGTTTGCTAC rsll216740 TCTTGTATTCTGACTC[A/G]ACCCCTGCAGACTGCA rsll219434 AATGTGAACTGGCTAA[C/G]ATGTAATGACCTTTTC rsll220561 TCCCGAGCATCAATAA[A/C]GTGTGTCATGATGTAA rsll221112 ATGGAGGCTGAGAACA[C/T]GCACGTCTTACAAGTT rsll221126 GAGAGACAGCTTATAC[G/T]CATGAATTGGAAGACT rsll225370 CAATCTTAACAGAAGA[A/C]GTGCCTGAAATCTACT rsll225377 TCCCAAAAGCAATATG[G/T]AAAGTGAATGAAACCA rsll225634 CAGCTTCCATTGTTAC[G/T]GAGGTTAACTTTACTA rsll235074 TTTGCTCTAGAAATAC[A/G]AAAGATGTCTCTTAGA rsll241892 GATGGGAAATAAACAGIA/CJACGGCAGAGAATAAAA rsll248591 TTTGGGTTCTGATGAA[CZT]TGTAGGTAAAGGGAAA rsll249885 TAAGGGTACCTTTAAC[C/T]GAACTGAATCTCTTCT rsl 1254023 GGAGACTTCAGTAATTIA/G] AAG AG AGG ATGTTCTC rsll254057 TTTAGACATGACACAC[G/T]GTATATGAAAAAGGAC rsll258652 TTTTACATCCTTGCTC[G/T]CCTGACTTTCATGAAA

rsll258827 AATαAAGTTAATCCA[C/T]ACATGAGGATATAAAA rsll258843 TTTATGGGAGGATGAAlA/TlTCAGTATAAAGATAGC rsll259145 CGTAGTCAATAACAAC[C/G]AAATGGCTGGCTGTCC rsll54436 TGπAAATAAATAAAC[C/T]AGGCAGAGAAAGACAA rsll57157 GAACACAAATCAAGAA[C/T]GAGTGCAATnTCTGG rsll577590 TTAAACTGGATACCGA[C/G]ACCCAGATTGAGGTGA rsll580655 ATGAAACATGTTTTCA[A/G]ACCTGAGTAGCTGGGT rsll589826 TGGTCTGTATAACAGT[G/T]AATGTGGTCCCTGGTT rsll595123 ATAAATπAAGAGAGC[A/G]CGGCAGGTTπGGAAT rsll595468 TTGCTCAACTTCAGTC[C/T]CTGTGTCCAATCCCAC rsll600876 AACAAAAGTCTCTGGA[A/G]GTGTTGTCTATATTTA rsll60217 ACACTCTCCCTGAGAA[A/G]CAGAACCTTTGATGAC rsll615637 ACAAGTCCACTCTGAA[C/T]CTCTCCAGCTACGGAG rsll624722 CACTTGAACAATTGGA[C/T]GTAATAGAAATCTACA rsll625370 TTCACTGTGTTCTTGA[C/G]AATGCCGCTCTGCAGT rsll648875 CTTAGAACATTTGTAA[C/T]CTGTCTTTCAAATGGT rsll653885 GATTAGATGAGGAATGIC/GIATAATGGATATTTGGC rsll656181 GCTAGATGACAACAAA[A/G]GTGAATGAATTACAGC rsll670955 CCTCCTAGAATGTCTC[A/G]ATTAGCAACCTTTTGC rsll678867 GACTTCTGCTGAAAAC[C/T]ACCTGGAAATGACGTC rsll688740 CTAGGCTTGAATGAGA[A/G]AATAACGATACCTTTC rsll691543 AACACGATAATAGGAAIC/GJAAATCTACAAATATCA rsll694629 TnTCTGTACCTCTGA[G/T]AGACAATCACTCAAAA rsll697499 GACTGGCCACTCTTCA[C/T]GATGACAAAAGAGCTC rsll700793 AGTGGGACTACCTGAA[C/G]CAAGTAGCAACAAAAC rsll702528 TGATGAACTACATTAA[C/T]AAATCACCATCACTGT rsll704699 ATAAACCAGATTGTTG[A/C]ATTACCAGGATAGATG rsll705997 GTGCCTGGTACATGATIA/GJAGCAATCAATCAGCAT rsll708432 GAAATTAGGCTTAGACIA/TJAGCATAAAAATGAAGG rsll713100 TTAATTGGTAGGGTGCIA/GJAGAAAGTAGAACAGCA rsll734396 GGCAACAACTCCTCTG[A/G]ACTTCTTATGTGAGGA rsll739158 GAAATCCTGGGTTAGA[A/G]GCTCAAAGTAAAGAAC rsll756315 AAAAGAAAAATATCTC[A/G]CACTTTCTACAAGTAT rsll757063 TTGGCCATCTTGGAAC[C/T]GGGCACTTTCAAGACA rsll760007 TnTTATCTTCTCCTA[C/T]CCTGAAACCAGATTGC rsll763010 AAATGAAAGAAATATA[C/T]CTCATGGGCAAACAAG rsll771454 GAGTCGGTAAGAATGA[A/G]TCATTAGGCTGTTGTA rsll77257 AAAATCAAACAGGAGA[A/G]CAACGTTACACAGAAT rsll776270 CTCTTCCTACTGTACA[C/G]AAGTTCTTCATGCTTA rsll827218 TAGCAGTTAATAGCAAIA/GJCATGTTATTGAGTATT rsll843348 TTTGTTGTTGTTCAAA[C/T]TATTAACTCTTAGCTC rsll845632 GAAATGCAGTTTGATA[C/T]GAGACACTGAATTGGG rsll846532 GGACTTTTATCAGGAA[A/G]CAATAAATGCATTTCA rsll848645 AGAGAAAATTAAAACA[G/T]TGTTGGCCAAGAATGC rsll850956 TGGTGATGAAGCCAGAIA/GJCGTAAACAGAATGATT rsll856921 ATGTGTTCTGCTTTCT[A/C]AAAAAAATGGAAAGGT rsll86143 AGCGATGCTACAACAAIC/TJGTACAACCCCAAAAAT

rsll862589 GGGTAAGTGATAAATC[A/G]GAAAGπAGTGGACGA rsll86919 AGCTTCTCTATCCTCA[C/T]GATGACAAATTTTGAG rsll869607 ATCATCACAAGCAATA[A/C]AACACTGAGACACTGT rsll872825 AGTCCAGAACTTCTAA[A/G]CTCCTGAAACACTTTG rsll931702 GATGCTGCTATGACCA[C/T]TCACTTACAAGTTTTG rsll93496 AAATGGAGAAGTTTAA[C/T]TGCCCTCCAAGACAAA rsll941453 GCAGAGGATCCAAAGT[A/G]AACCCAAGCTATTCTC rsll951359 CTGTAAACTTCTATAC[G/T]ACTTTGTACCACCCAT rsl 1966463 TG ATTGCTAACACGTG [A/C] ACACTTACCATGATTA rsll973145 GTTTTGTTTGGCATAC[A/G]GATU I I L I I GGTCAT rsl2002851 AGTTATCGTGAAACCC[A/G]GCATTCATAAAAGCAG rsl2021074 TATAGAAGCTATCACAμ/G] AACACATTG ACTTTAA rsl202761 TCACTTCTGTTACAAA[A/T]GAAAGGGAACTCTCAA rsl2032691 AGATATTCTGAAGTCA[C/T]GAGGAGCCTGGACTCT rsl2042555 GCTCTG AGTTCCTGGG[C/T]CATCGTTCTCCCTGGA rsl2043406 TGAAACACTGACTTTC[C/T]AATGGTATTTAATTCG rsl2043606 AAATGCCTTTTACCAA[C/T]GTCCAGCTCTAGAAGC rsl2046579 ATCTTACGTTGTTCTG[A/G]ATTTACTTCTTGCATT rsl2049347 TACCATTTTGAGATTC[A/G]CCTTTTCAACACAACA rsl2052971 TCTGTAGAAAACACCA[C/T]AGAGGATGTGATACAT rsl2097383 ATTTTCCTGAGTACCC[A/G]AATGAATGCCCATTTA rsl2123182 GGAGAATGAGACCACA[C/T]GTTTAGAGTGCCTTCA rsl2131306 TTTTGCCCTAACAAAC[C/T]GCCTTCACAGGCTTCC rsl21317 GCACTGCATATTGTAC[C/T]GAAAAACGTCATGGCC rsl2131909 TGAGATTTATAGGATAIC/GIGAGAAAAACAATGCAA rsl2145301 TCAGG AG AAATGTAG C [C/T] CAG GTCTG ATTATTTG rsl2147614 ATCGCTGACTGAAAGA[C/T]AGGTCAI I I I IAAAAT rsl2154282 TTCATTCATTGCTGGA[A/G]ACAATTTAAATATCGT rsl2161700 TTTCTTGAAG CACTCC [C/T] AG ATTCTC ATAAG CAG rsl217580 GTCAAGTCTATTTCAA[C/G]TCTGTTTCCAAGTCTG rsl2186753 GTCCCTCTATATGCCA[A/T]GGTCCCTACAATGGTT rsl2207570 ATGATAACAACGATGA[A/C]GTATTTCCAAGTTCGG rsl2208449 G CCTAAAAAGAATAG C [A/G] CCATCGAG CTTTTTAA rsl2208556 CTAGGAATAAAATAAAIC/TJGGGCAGCTATGAAAAT rsl2210146 AATCTGGCTTCTTACA[A/G]TAATAGCTCTGACACC rsl2213375 CAATACTAAGAAACTCfA/GJCTAGAATGCAGAGCAG rsl2220888 TCCCTCTCACTTGATA[C/T]GACATCTTATCCAGCA rsl2227177 TGAGGTTGACAGGAAA[C/T]GGCTGTGCATAGATCT rsl224096 ATGTTATTTAGCAATG [A/G] AAATGG AGTAATG ATA rsl2245107 CAGTATCTCCAAAGGC[A/G]AAGGGAAACTGAAAGG rsl2271990 TCAGATAAACAATGAA[C/T]GACATTTTCGTATAAG rsl229979 TG ACTCTAGAATCAAG [A/G] ACTTCTATATATGCTG rsl2307841 CCTCAAACTGATTCCA[A/G]TAACCATTCCAGAATC rsl2329306 AGTTTTCTAACACCAA[C/T]GAAAGAGACTCTAACC rsl234805 GACACATTACACCTTA[C/T]AGAGAAGCAGTTTCTG rsl2413650 GGGCTCTTTGCTTGCA[A/G]ACCAGTTCATCATACC rsl2420058 GAGCACCCTGTAACTC[A/C]CAGAGCTGTAAACATT

rsl2427691 ATTCATATCTCCATTA[C/T]CATCAT6TAATAATAG rsl2428162 AGATTTCTTGATTGCC[C/G]ATTTAGTGTTAATGTC rsl2442570 GTCCGCGTTTTCACAA[C/G]ATCA ^" mTCAATCTGC rsl2443955 GTCTCAGTCTCTAGAC[C/G]AGGTATTCTCAGATTC rsl2447906 CTCTCGCTAATTCTGA[C/T]AAATCTCTCATGAATC rsl2452883 ATATACTGTAGACTTA[CZT]AATAAAATGAGCTAGA rsl2458118 AATTTTGAGGTGATAC[A/T]AGCATTTAGTCCAAAG rsl2460612 GTTTGTTACGGAAGTAIC/TIATTGTGTGTCGTGGGG rsl2465363 ACTGTAATTTCCCTAClA/GlGCACTGCAGAATACTA rsl2472797 ACAGATCAGATTTATC[AZG]CTTTGGTTACATCCCT rsl2488732 ACCTTTAACCCTGGTA[CZT]CATTTCAAAGTCCAAC rsl2503170 TATCCCCAAGTCTCCA[AZG]GAAATGTAGCTTATGT rsl2505447 AGGGGGTTGTGAACCC[AZG]AGGGAACTGCTCTGCC rsl2509242 CATGAAGACGATAGAA[AZG]ATGTTAGCAGCCCCAA rsl2521059 CAATGTTTATTATCTC[CZT]CTTGACATTGCTATTG rsl2530533 TTTGCAATAGCTACAA[CZT]GGTTATAAAATACTTA rsl2531431 GTAAATGTGGAGAAAC[CZT]GAAACAATTTTACACA rsl2536448 TATACACCGTGGAACA[CZT]GAGTCATAAAAAACAA rsl2536742 AAAGATAATAAGCCAC[CZG]ATTGTTCTAACAGTAG rsl2539892 ATGAGGGGCAAAGCAC[AZG]AGGGAGTAGGAGCTTA rsl254531 CAGTGAACACTTGTAA[AZG]CCATTTTCCAATTCAA rsl2546625 CAGCAAAGCATAGTTA[CZT]GTAAACTTTCAAAGTA rsl2552979 TTTGTAAAGCAAGAAC[GZT]GACTAGGAACCCCTGT rsl2570123 TTTACATTATTCTGTA[CZT]AGATATCACCTGGTGT rsl2575085 AAGAACCTGACATCCA[GZT]AAGTGGTCCTGGGGCC rsl2580234 TTTTCTTTATCAGTTC[AZG]ACCTTCGATGCGTACT rsl259457 TAGCTGCATGATTTAA[AZG]CATGTGAAGAACTCCT rsl2595945 ACTTTAAAAACGAGAA[CZT]TGGAACTGTCTCCCAC rsl2606388 ATTCACTTAATGGTGA[CZT]CTGTAAGTCTGGTAGG rsl2606388 ATTCACTTAATGGTGA[CZT]CTGTAAGTCTGGTAGG rsl2614381 TAAGTTCTCTTTGCAA[AZC]GTAACAGTAGCCAACA rsl2620263 TCAGACATTTCCCTTC[AZG]CATCTCTAAAATGTAC rsl2622278 AAGAGACAAAGAGAGA[CZT]AAAGTAGTCAAATGAC rsl2634945 TAAAGATGGAAGGCAC[AZG]CATTAGTATTAGACCT rsl2657171 TGCTGAGTGAACACAA[AZG]CAGTAACCTATGTTCT rsl2669859 AATACTTAAGGTTCAA[AZT]TCTGGAGTACACAAGA rsl2674699 AAAGGCCATCCCTGTA[CZT]GTTCGCAGAGACCCCA rsl2679360 AAAATTTTACACATCA[GZT]TCAGCTTCCTCAGGCT rsl2681298 GGCTGAGAGGAGAGAA[AZG]TAAAATTTGAACAGTG rsl2695902 GGATTATCAGCATTTA[AZG]GCCAGAGTTGCAAATT rsl2716433 TGCTTAAAGTTAACAG [CZG]CTCAATCTAAGGATCT rsl2726588 AGTTCAGTGTGCAAGA[CZT]G I I I I I I AAGGAGTGA rsl2750223 AATCTAACACAGCTCC[AZG]AGAATTTTCTTCTGGT rsl2779831 TCTGCCATAGAGTGTA[CZT]AGAGAGTAGCCTGGTA rsl2802285 ACCTATCCCGTTGTCG[CZT]AAAGCAATTTATAGGA rsl280680 ACCCAATTTGTTTTTA[CZT]CAGTTGGAACACTTTT rsl2814669 TATCATCAGCTACACC[AZG]AACACTCAAGTGTAGC

rsl2896523 TGTATTTGTAAGAGTA[A/G]GTAGCATAAATAATTC rsl2907914 TTTGAGATGGCTCACG[C/G]ACAGTATGATGGCTCC rsl2937300 GCATTTCTTCTGGCCA[A/G]AGTTGTAGCTGATGAA rsl2954795 TCAGAACTACAGGACA[C/T]AATTAACATCATGAAC rsl2965571 TTCAAAAAAAGTGTAC[C/T]ATTTCCATCTGATCAG rsl2965580 AGACTGTATGGCTGTA[A/C]ATATAGGCAACGTTTG rsl2987038 ACAGGGTTCAAACAAC[C/T]GGCTACGTCTGAGTGG rsl30250 GTGATGGTTGGAGAAA[C/T]GGGCACCTGGCTTTAA rsl3039735 GTTTAATTCTCAGACC[A/G]AACACCAGAACCTAGG rsl3070108 GAGGCCTTCTGTATCC[C/T]GACTGTGCTGGTGATT rsl30834 AGTGACAAGGTCTGCA[C/T]CTTAAAAGTTCTCATT rsl3120271 AGTATAATTCCAGCTAfA/TlGAAG ACAG ATACATTG rsl3127656 TTTTTTTTAGGGTCAC[A/C] AATCAGG AGCAAATTT rsl3128284 CTCAAATCTTCCTTCC[C/T] ACATCCTTAAAAATCT rsl3138476 TAATTTCAGGTTTGAC[A/G]AAATGTAACAAATCAA rsl316395 TGACACACAGACTGTA[C/T]GTGAGCAACACTTAAA rsl316801 TGG AGGGG ACTGTTG A[A/G]G AG AAG AAAGGGTCAC rsl3173656 GTACTCTTATCAGGCA[A/G]GACATTTCCATGGCCT rsl3185405 ATTGGGAAGATGTGAA[A/G]CCCTGGGAACCCACAT rsl319458 TAGAAATATCTCAAAAfA/TJTGGAGAGCAAAGGAGA rsl320865 CAGATTGCTGAACTTC[A/G]CAAAGGCTAGAGAGCT rsl3234372 TTTAGCACAATGTTTA[A/G]CAAAGACTTCATTAAT rsl324465 ATGGCAAAGTTGAATAfA/GjACAGAGAGTGAATGAT rsl3250299 GTCTAGAACTACAGAC[A/G]CGGTAATCATGTGCCT rsl325267 AGTTAAAATATGCTGA[C/T]GCCCCTGCATGGCCAG rsl3259448 CAGTTATTAAAAAGCqA/GlAAGGAATTAAGAAGAA rsl3263794 GTG ACCTTG AAAAATG [A/G] AAGG AGG ACATCTTCC rsl3266699 CTTCACTAGCTAG ACG [A/T]CCAAGCAGTTATG ACC rsl3267118 TGCCACTATAGCCTAT[C/T]ACGCAAAAAATGTAAG rsl3273013 AGTGATAGAAATAACA[C/T]TGTATCTGGGTTCATT rsl3276054 GAGTTGTCAAAGAGGA[C/G]TCACAGCAGAGGAAAA rsl328907 CTACTGCTTACTTGAA[G/T]GTGCCTGACAAACCCA rsl3316352 TAAGCACAATATTGAA[C/G]TATAAAAGACATCTTG rsl3326400 ATGCAACATπTCTCA[A/G]TAAAGATGATTTTCCT rsl333996 GAAAACAGACTCATTC[A/G]CCAACAAATAATGGAT rsl3353636 TCTCACTCTCTGACTC[A/C]CCATTTTAATGAGCAA rsl3353636 TCTCACTCTCTGACTC[A/C]CCATTTTAATGAGCAA rsl335655 TTTTGGGAGTGCAAATtA/GlAAGTTTCCTTGAAGTA rsl337966 AGAGTTCTGCTACTAAlA/ηATATGTTAGAATTGTG rsl338195 ATGGTTCCAAGTTGCC[A/C]ACAACAAATGTCGCAC rsl3382085 CTGTACACCATAAATA[C/T]GTATCTTTCTTGTTTT rsl3406490 GTTACAAAGTCTCACC[A/G]GATGTGGGATGTCAGG rsl3423425 GCAGTTTGAGACCGGAIG/TIATTCTCCCAGATTTAG rsl351719 TACTAGGTGATATACA[C/G]ATATTCCAAAGACTGA rsl35439 GGGCGGGTGAGGATGC[A/T]CTTCCCTTTTTCACGA rsl357814 ATTATATGCAACTTTC[A/G]CAATCTGCAATGGACA rsl36OO2 ATCAGTGACAACATCA[A/G]TCCAGAGTGTAGTAAT

rsl36026 TGCTAAGTGTGCTCTC[A/G]CGACCAGTCCATCCAG rsl360411 TGGTTTTCAGCACTAC[A/T]CTTCCTAAGTAATGTT rsl360422 TGCAAGGTCAGTGCATIC/GIAACCGCTAAGAAGGTC rsl362936 ATTGCTGATGATGCAA[C/G]GGCCTTCCAAGTCATG rsl366460 TTCAGGAACCAGATGA[C/T]GTACTCAAATGCAATC rsl376985 TGTGTTTGTGTGTGCA[A/T]CCAATACCTCAGAGTC rsl379666 CAGAGGGGAAAGCACAIA/GJTAGACAAGGTCAGCCT rsl384300 CCTATTCTGCTGTGCA[C/T]TAACACTATAATTCTC rsl385662 AGGTCTTGCCTGGTCC[A/G]CAGTCTCTTCAACTTT rsl389798 CAAATCAGGGCAAAAAIG/TJTCAACAGCTTCTGCCC rsl392326 TTTTAAAATGTG CCTA [C/T] GTCCTTCC AACTGTAT rsl396512 TCATCTCTCTATCCCC[C/T]GAAACAAACATTTGAG rsl397706 TAG CTTC AG CCATGTG [A/G] ATG AAATAAAG G AATT rsl398899 TATGAGATTGAGTACA[A/C]CAGCAACTAAAGGGAC rsl401209 TAAAACAATTAATGGC[A/C]ACAAAGACTAGGAGGC rsl404868 CAGTTCTG G AATAG AG [A/C] ATATTG ATTTATG ACA rsl405377 AGCAATCAAGTGGAGAIG/TJAAATTATCGATGTCAG rsl413896 AAGGTCACCAAGTTGA[A/G]CATGTATATGGCACAG rsl428658 TATGAGAAGACCAGGA[A/G]TCCATTTCAAATTAAT rsl446074 GCTTCACTTTCCACAA[C/T]TGAAGTTACTCATGGT rsl453012 TCTGCTACATCTTTGA[C/G]ATATGGCCATTGAACC rsl453688 AGACTGGCAGGCAATA[A/G]GGACCCCAAAAATGGT rsl454285 AGGATGAGAGTTTAGA[A/C]ACAAGACAAGCGCATC rsl456994 CCTπTCAGTTCCTAC[A/G]CAACTGTCTTTGAGTT rsl460607 ATATCTTGTGCAGGAAIA/GJAGAAATAAGTTGTTGA rsl466462 TGAGGGTGTGTCTGCA[C/G]AAAACTCGGATCTGGT rsl481384 AGCCTGACCACAAAGA[A/T]GTTGCTCTTTCTGCAA rsl484255 AATAGGAAAGTAGCCA[A/G]TGCACATTACTGAAGG rsl484992 GAAACAGTGGGCATAG[A/G]CAGAGCAGTTTCAGGC rsl487025 ACACAGCCTATATGCC[A/G]AATAAAACTAAACTAT rsl487802 AGTGCTCGATTATAAAIA/GJTATGATGATGATGATT rsl500292 CTGGGGTAGAAGGAGC[A/G]CAAAATAAACCAAAAC rsl50073 TAATCTCTATTTCATA[C/T]CCTTAACAGGCACCAT rsl507214 CTTTTCACTATCATCA[C/T]GAAATTCCTTTGCTTC rsl507216 GGGTAAAGATAGGTCAIC/GJATGAAGTAATCTCCGC rsl511098 GTAAAACCTAAAGGAAfA/TjAAAGCAATGAGGCAAA rsl513679 TACCAAAATTCACACAIA/GJGAAGATATAGATAATA rsl513681 CTCCTTCAAGTAGTCG[A/G]TAATTGGACCTGATTC rsl514417 GGATGAAGTGAGATAAtC/ηGGCAGGATAGATATAG rsl515633 GGGAGGGTGATAAAAA[G/T]GACCCTGTTCTACTCA rsl518909 CTAATTAAAATTAAGC[A/G]CCAATGAATAAATAAA rsl520472 CTTTCAATATTTATGA[C/T]GTTGTATGTGTGTCTG rsl522469 TTTCCAGATACAGAGA[G/T]AGTTTGCAGAATGGTG rsl523890 ATGTCTC ATTTTG CTC [C/T] CTTTG CATATTG CCCT rsl524181 TTTGGAATCCCTAATAIC/GJAGCTTAAATCACATTA rsl52454 GGATAAATTGCTTTCA[C/T]GATTAGCTCACCTTCT rsl528490 TGATGGAACTGTCTACIC/ηAGCTACATAGGGATAT

rsl532885 AGTCAGTATATGTAAAIA/GlTGAACATTGTTTTGGT rsl536792 GTATACTCAATGCTTG[C/T]AACTTGTTTTAAACTC rsl540369 CACTCTAATGCACATG[C/G]ACAATAGGCAAGGCAG rsl540899 TGAAAGAGTGCTCTGA[C/G]AGATTAGGAGTGCATC rsl541749 GCAGCTTTGTGCACTC[A/G]CTGTCTTTGCAAAGTG rsl542744 GTTATGTTTTGCTGCA[A/G]ATTAAATCATTCCCCA rsl550243 GTGGGGAGGTAACATA[C/T]CATCATATTGCTAATA rsl550250 ATGGTAAGTTATATGC[A/G]CCTCTGAATTTAGTGC rsl558531 TGGTGTTTTCTCATCA[A/C]AGATCTGTTCAAATTA rsl558532 ACACAGTTGCTGAGTC[G/T]GAAGAGGGGGAAAGCT rsl558533 TTAGAAACCAGCCACA[A/G]CATTTGGGCACTCCAC rsl559145 GCCTGTTTTCTACTTA[C/T]AGCACATCACGATTCA rsl560346 GAAAACGATTTCTTTC[C/G]AGTCCTGAAATAAGTC rsl560718 ATAACGTTAGTTGGGA[A/C]TCAAGCAACAGAAAAT rsl564860 TGGAATTAGGTATGGAIA/GJGGAGAGTGTAATATCA rsl568272 TGGCTTTGATAATTCC[C/T]AGGTTCTCCATAAATC rsl56851 CTAACTAAAATGTTCT[C/T]AACGCACTAAATGAAA rsl576939 AAGGCAGTTACTTGCA[C/T]GGCTCAGCTTTCAGCT rsl595764 ACCAGCTAAGTAACAG [A/G]CAAACAG ATCAATGGA rsl601435 GCATATCCTGAAGTTA[A/C]CACAAAAGCATTGAAA rsl603614 GTTATGTATCACTTAA[GA]GACAGAGACACATTAT rsl604587 CCGCCACCTATTTTTG [A/T] ATAAGCCAGCTG AATC rsl610 TmTAAAGTCAATAC[A/G]ATGGAAATCAATAAAT rsl614316 TTGGCTATTATTTGGC[C/T] AATTCAAAATATCCAG rsl618798 TAACAAGCAACGTGTA[C/T]ATTTTGCTCTACTACA rsl630807 AAATCTCTAAACTCTA[A/C]ATTCCTGTGCTTAAGA rsl645410 TTCTGGGCATATAGAA[A/G]GATTAAACTCCTAGTC rsl66412 GCTTTAAACCATGACC[A/C]AAATTTAAGGTCTAGA rsl673518 ATCCATGTTCAAGATA[C/T]AGGCCAGCCCTCTAAG rsl674241 AGTCTGTCCCTAAAGC[A/G]CAGAGTTGAACAAGGA rsl6822521 TTATTTCCAGTAAAAAtC/G] AAGGCATAG AAATTCC rsl6825798 TGCTGAACAAAATAAT[A/C]ACCGTCTCAAAAATAA rsl682586 GTTCTCTCCCAGTCCA[G/T]TCAGCAAAGTTAAGAG rsl682604 GTCCAGTCCGGCGATA[C/T]GCTTGTCGCTTGTATT rsl6838929 ACACGAAGAGAAGTTA[C/G]ATAAGATTGGCAAAGT rsl6838943 GTTCTTACGTGTTCAC[C/T]CAACGGCACGTTGACC rsl6849108 TGTAAATGTGCATCCA[A/G]GCTGATATTTGGTCCA rsl6849387 CACCTTAATTGGATTC[C/T]ACTGAAATAGCCATCC rsl6854019 CTGAATTCAAATCACA[A/G]TCTTCTGTCAACTGAA rsl6855116 AAATGTCCCTTGACAA[A/G]TAGACTGTCCCTGTTA rsl6862598 GAATGATTAGCAGATAIC/TIGGCAGTGGAATTAAGT rsl6865535 GGATGCCCAGTGCATT[G/T]AAAATCGAAACTCTTA rsl6871059 CCTCGGGCAAGCCCCA[C/T]AAGCACTGTGAATATG rsl6880395 AACTCTGGTGTTGACC[C/T]AGCGGGTAGCATGAGA rsl6882335 GGGAGACTCACAGCGA[C/T]GATGAGAGAATAAATT rsl6889490 CAACTGTTAAGTGGAAIC/TJGTAATAATACAGGGAT rsl68965 AGGCCTCACAATTAAA[A/G]CTGACTACAAAAAGAA

rsl6905587 CTCTTATCAGTGGCTA[C/T]AATGACTATGAGAAAA rsl6906665 CATAAAAGTTGACTTA[G/T]AGCATCTGTGTGTCCT rsl6910679 CTCTGCTAGTTGTCCA[C/T]GTTTTTATTGAAAGTT rsl6915836 TACATCTTTACCTAAA[A/G]TGATTAACAAGTAGCC rsl6921797 AAGTAGTGCCTGATTA[C/T]AGCTACACACTATAGC rsl6930564 CGGTAGTCTTGTCATG [G/T] ATTTCAATTTTCTATG rsl6931436 AGAAATGTTTGTTGAA[A/G]GTCCATGTCCCTACTT rsl6935391 TTATTAAGCAGAACAG[A/G]CGACCTTTACTCTTTC rsl6937197 TACTTCTGAAGCATGA[C/T]GCTAGAGTGGAAAGAA rsl6941191 GTGAGAAATCAGCCAA[A/C]GAGGTTGATCGAGTGG rsl6941250 CCCAAGACATCTCGCA[C/T]GTGCAAACACCATGCA rsl6943700 CCCCTAACATTTGACT[C/T]AACAACACATTCCATG rsl6948951 GGGCCACATGCTGATA[C/G]GTGAGAGGCGGTGGGG rsl6948981 CTTGAACTGAGTAGGC[C/T]AAAAATTTGCTTTCCT rsl6949733 ACTGGTTTGGAATTCA[C/T]AGTCACAATTTCTTGC rsl6954017 ACGTTTTGTTTATTCA[A/T]TCCCATCCATGTGCAT rsl695624 TCAAAGTCCCACAAAT[C/G]ATGAGGTTTTCCAGTC rsl6969797 TTAACTCGAGTGGGCA[G/T]AAATGACAGCAGATGG rsl6973718 GAGGCTCTGCATCCAG[G/T]AATCCAGGCTTCTAGT rsl6975959 TAGCCCAACGGATATC[A/C]ATGAAATACTTTGCTT rsl6988107 CATTCCTGTGAAGTAC[A/G]ATGCACTCCCAGGGCT rsl6988954 CCTTGCTGCTCAGGAA[C/T]AATCATTGGAACTCCA rsl6994496 GGTTAACTTCTTTTCA[A/G]TACAGATGGTTTAAAA rsl7004748 AGAACAGGTATTACAA[C/T]TTCTAGTTACTAACAA rsl7011383 CCCATGCTGCTGTAAA[C/T]GGTTAGAATAAAAGCC rsl7021814 TATATTAGTGACACTA[C/T]CTTGATCAAATTGTAA rsl7022224 AAGTACTGAATGTAAA[C/G]TTCTCTATCAGCTATC rsl7025374 AACACGTTCACATTTA[C/T]GTCTCACTTGAAGCAG rsl7025378 TCCCACCCTCTGTGAG[C/G]CTATGAGGTGCCATTT rsl7027538 GTGCTTTGCTTTAGAT[C/G]ACTGGTTTGTTTCTAT rsl7027580 AATCTG CTTTG AAATG [C/T] ACAGTGG ATTGGGGCC rsl7027581 TATATTTAATGAATCA[G/T]GTTGAAAATTCCCTAT rsl70286 ACAATAACTCATGGAC[A/G]ATGGCCTAGCTGGTTA rsl7029753 AAAAGTAGTTCTAAAA[C/T]TTGCTTCCTTTTGTTA rsl7029754 CAGTCAGTTGAATCAA[C/T]AGTCATAAAGTTGAGT rsl7031883 AATTTTCCTGTGCACT[A/G] AAAG AAGCAG ACATAT rsl7033705 CCAGGAGTATGCAAGC[C/T]ATGTTATTGAAAGAAA rsl7035158 ACAACAGAAAAGTACA[A/T]AAGAATTTGCCAGAGG rsl7038574 AGCTACTGTTATTTTAIG/TIGATAGCACACTTCCCT rsl7045564 CAATGCAAGGCAATTA[A/G]CACTCCTCTTGTGTCA rsl7045568 CAATGGCCATAGGGAC[A/C]GGTGCACACTCCTGAA rsl7056425 CAAAGTCAAACACAGA[A/C]CAGAATGAGAGAATAA rsl7056483 AACCAACCAAACAAAC[A/C]AACCTGGTATCTTGGG rsl7060205 GATAAAGATCTGCATC[A/G]AAATCTCAGTTCTGCC rsl7060235 CACATTTGCTTTAAAT[C/G]AGGACATGTmTCTC rsl7060302 TCCTTGGATAAAAATC[C/T]AGTGAGATGGTTTCAG rsl7064344 AGCTTGCTCTAGATCA[C/T]GGAAGTCAAAGCTTTC

rsl7070608 GTTTTACTATGACACAtA/GlTAGAGGTATTATTAGA rsl7072025 TCAGAAAATGCTGCAA[A/G]TTCCTGGCACTGCCTG rsl7075007 ATGGATTTAGCTTGGC[C/T]CATCAATATTTTAAAG rsl7081619 ATTATCTCCTGAAGGA[C/T]GATTTAGCAAATTGAT rsl7081709 TTATAGAAGCAATTGA[C/T]ACATTTGGAAAAATCA rsl7088990 CATACTAATTCCTTGC[C/T]CACCATTTTCCTGTGT rsl7090075 TTTACTCCTCTTTGGC[C/T]ACAGTTGATGGGGGAC rsl7090089 AATCCCTAGAGGAAGA[C/G]GACAAGATAATCAAGA rsl7093383 CAGTTGGCAGTAAGAG[C/T]ATCATCACAGTTTTCT rsl7094227 TTATTAGGG ATACAAG [A/G] CCAAAATAG AAAAATA rsl7099196 TGGTCTGAGGCAGTTT[A/C]AAAATTGAGAGACAGT rsl7099254 TGAATCAACAACTGAC[C/T]GTATAAAACTATGCTT rsl7104962 CTTG I I I I I AAATCCT[A/G] AAGTCATGTCAGTTTT rsl7105368 TAAGAGGTTATGACCC[A/C]AAAATGAACACAAACC rsl7113360 TCTCTCTTCCTAAATG[C/T]AGTACCTGATGCTTAC rsl7113374 AAATGAGAGATGCCAC[A/G]ACATATAGGACAACTA rsl7114146 AATCAGAAATTAGGTA[C/T]GAGGAAACCAAAGCTT rsl7119981 AGCATTCCCGGCAACA[C/T]GATGCACGGCCCATTT rsl7124993 GAGTCAGAGCCATATC[C/T]ATCCTTCGGGCAGCAC rsl7126675 CTCAAGGCTCTAGACA[C/T]GAAGAATTGGAAAAGG rsl7151591 GAATTCAGGTCCAAAG[G/T]CTTCCTCTCTCATTGG rsl7151705 TTCTACACGATGCAAT[G/T]AAGGCTTACTGCCATT rsl7154998 GATCAGTTTTATAAAAIA/GIGATAAGTGGCTTTTCA rsl7156145 CCTTGTCTTCATCCAA[A/G]TATTTCTTTTCGCTTT rsl7171382 TTACCCTTTCCCTGAG[A/T]AACATTGTACATATCC rsl7172953 AGATTACACTCCCACA[A/G]GTGCACGTTGCAGCTC rsl7183465 TCTGAGCATTCTTAAG[A/T]CACTCTAGCGAGGCCA rsl7191463 AGTCCATTTGTGTACA[A/G]TCAGAACCTTTCAACC rsl7207852 GACTTTCATTCATTTA[C/T]CAGATCCAACATTGAG rsl7214746 GATTAAATTTGTAAAA[C/T]TGCCTTGTTACTGTCT rsl7229383 CACAAGGGCTGACCCC[A/G]AGTTGTTTTCATTCTG rsl7259942 TTGTCACCACTACTAG[A/G]AATTAATTGCAAAGAA rsl726254 GGCAAGCTCAAACATC[A/G]AGCCTTGAAGGCAGAG rsl7282551 GAGCCATGCTCTGACC[A/G]AGAAATATCTTTCCTC rsl7296210 AAGCTGGTTATTGCCAIA/GIGCCTATTAACACTTAA rsl7303597 TTGAGCAAATCTTTTA[C/T]GGCAGTTTTCCTCATA rsl7309228 CAGAACCCTCACCAAA[C/T]AAGTGGTAAATATTGT rsl7328164 ACAGGTCGGGGCTGAA[A/G]TAGTAGACAGGCCTTT rsl7334370 ACAGCTTCCATTTTAC[C/T]CATCATCCCCATTTTG rsl7343615 AGTAGGGATGGCTCCA[C/T]TACACATTGGAGGTTG rsl735512 TTCATAGTCTACCTAA[A/T]TGATTCCCCAGAATTA rsl7368812 AGCATGAGTCCTTGCA[A/G]TAATCTTTCCAATATA rsl7371162 CTTTCTGTGAATGGAA[A/G]CTCCATGGCTTAGGAA rsl7387008 GATTGCTGGTACAGAG[A/G]AATTGTAAAGCCCCAC rsl7391002 TTTAACACAGGCAGCC[A/G]AAGAGATGTCACCAAG rsl7394217 CATATGCTTTACAAGA[C/T]TCATGGATTAATAAAA rsl7428956 TACTGCACATGTTTGA[G/T]ACTCTCACTCTACCTG

rsl7435665 AAATCCTTTTCATGCC[A/T]CTATGGAATGTCCCAT rsl7444745 AGATGAGAAGGTGCTC[A/G]CATGGAGCGTCCGGGC rsl7459837 ATAATAGATGTAACAAfA/TJGGCGATGATGTAATAT rsl7477680 GTATGAACATTTGACA[C/T]TGTAACCTATTACTAT rsl7484259 TCTCCTTTAGCAGTTA[A/C]CACTCTTGCTCTTGTA rsl7560858 CTGTGACTAAGCTGTG[C/G] AG AGGTTG ACAGCAGG rsl7564220 AATAAACG ACAAAAAG [G/TJAGTCAGAACAATACTT rsl7567053 CTCTCTTTCATCCATG [C/T] AAC ATTATAG CCATTA rsl7573753 CTCTTCCGCTTGTCCC[A/G]AAGTCAGGGCTGGCAA rsl7601491 GTCTTCCTTGTTCCAA[C/T]TGAAGATATAAATTGC rsl7602774 TTAATTCTTCTTACAG [A/G]CCAAGTAGCACGTTTA rsl7609346 GTTCATATGCCCTGCC[C/T]GGACTCTAACAGGCTA rsl7647040 GGTCTTGCTCTGAATA[C/T]GATCCTGCAAGGAGGC rsl7647607 CTTTCCAACAGGTGCA[A/G]TCAAGTCATCCGTGTA rsl7674783 TGTCAATGAAACACAC[C/G]AGAGAATTCGAAGTCT rsl7675026 CTGAAGTTCTCATTAA[A/C]TATGTCAAAACATATT rsl7680407 GAAGTGTTAGTGATGAIC/TJGGACAGAAATAGACAA rsl7680905 AGATACAAACCAGATT[C/G]AAAGGATCTTTAATAT rsl7692461 TATAGAGGATGAAGCAIC/GJGTTTAAAAATTGGACA rsl7736364 AGGCCATTTTACAGCA[A/C]ACTATGGTCCTTAATC rsl7748393 TATACTCACTAAAATC[A/G]AATCAATTATACAACT rsl7750221 TCAATGGAAACTGACC[C/T]CAAAGACACTAAAAGA rsl7750246 CTGTACCCTCATGATA[A/C]CTAAGTCTAGAAGCCA rsl7750253 TTACTACTAAATAAAA[C/T]GTCGTAATGAAATTCA rsl7753899 GGCATCTTAGCCCTCA[C/T]GCCGTCTGGTGGGTGG rsl775401 GGCTGTGCAAGGTATGIA/GIATTGAAGGTTATTTTG rsl7763040 CATGATGTCCTAACAA[A/G]CAMTTATCACTTTAA rsl7768420 CACCTGAAAAACTGTA[A/G]AAGTGAGCATGGCAGG rsl7774514 GTAAGCAATAAAAAAA[A/T]GTCTGCTGTTGCCAGT rsl7781350 CCCCAGCATGTCCCGC[A/G]AAGTGCTTTTCATGTG rsl7783776 CTTTCTTGCATACAAA[A/C]CCTTCACTAATAAGGT rsl7796589 TATCTGTTTTACACCA[A/G]TGAAAAGTAGATGCCA rsl7806588 TCCTTAAGCAGAATAA[C/T]ATCAGATCAAGTGTAC rsl7807662 TTAAAGGGACCACAAA[C/T]GCTGGGTCAGTGGACA rsl7815316 CACTATATAGCTGGCA[A/C]CCAAATTTACAGAGAT rsl7820836 AGTTATTGAATGTCTC[C/G]CAATGTCTCATTGTGC rsl7825174 CCTCAGCTGTAAGACA[C/T]GATGAATGAGGAAGGA rsl7826186 ATACTGATTGGATAAA[C/T]GAACAATTCGACACAC rsl7836256 AGACATAGTGGGCTTA[C/T]GTGAAAAACACCCAAC rsl7836431 TGAπCTGCCTCTGGA[A/C]AGGTCTCTTAATTCCT rsl7838321 TTTTAGTACATCTCCA[A/G] ACTCTCAAACACAGAC rsl81930 ATATAAAAAAGCTCTA[C/T]GGCAGTAATTTGCTAG rsl821443 TGGGATGGCCGACCTA[C/T]AGGAAGGACTCCTTGG rsl827545 AATACATTACTCACAA[A/G]TTACAGAAAGCATCTA rsl827546 GAAAACTAGATTAAAAIA/GJTGCCATGAGGATTTAG rsl835742 CCTTGTGTGGCAAGAC[C/T]AATGAGTATGCTCGTG rsl844261 CAAATTGGTAAAGAGT[C/G]AAACTGTCGCTGTTTG

rsl845624 TCCCTGTTTGATGTCA[C/T]GAAGCCAATATATGGA rsl853772 TACCCTGTGTTAAAGA[C/T]GTTTGCCCCTACATCC rsl859898 TAGAGTGTACAAAGAC[A/G]GGGGATTTCCTTACTG rsl861576 ACTGTGGCTGAAATCC[A/G]GCTTCAGGACCAACCG rsl862230 CAACTATTTAACTGTA[C/T]CTTTGTCGTACAAAAA rsl866065 ATGGGG AAGTOTGGG [A/C]AGATAACTCAATGCCC rsl868247 ACTCTCTTG AATAGTG [A/G] AAATGTTTTACATCTG rsl868248 CTCTπTAGGTGTTCC[A/C]ATTGCTTTCCAAAGTT rsl868249 TTGGGCrTAAAATTCA[CZG]ATTGTGTGGTATAATT rsl868250 TTTAACAAACTGATAG[A/G]CAAACTTAATTTTGGA rsl868727 CCACTAATAGATAGCAIA/GJTAACATCAAATGTCAA rsl869885 GAGATCTGATTGAAGA[AZG]GAAACCATAGCACAAC rsl870506 TGTGATCCAAI I I I I C[A/G]ATACGTTGGGCAAGAA rsl875205 CTATTAGTTACTTTCCIA/CIGACTCTCTTCCTCCTC rsl876681 TAAACACTCTCATGGA[A/G]CATCAGTGTCAGACCA rsl876852 ACCTGCGTGAAGCTGC[A/G]AGGACCATGCCTGATG rsl881441 TTATTTGAAAATTATA[AZG]ATGACTGAGGAAAGTG rsl881441 TTATTTGAAAATTATA[AZG]ATGACTGAGGAAAGTG rsl885290 GTTTTCATCAGTATAA[CZT]GGGAACGATCATGGTA rsl885574 ACCTTTTCTAACATCA[AZT]GTGTCATTGACACCTT rsl888516 CTTCTTACCACTTCTC[AZG]AATGAGCATCACGTTG rsl88918 TGTGAAAAGAGAAGAG[CZT]CATTTCATTTTAACTT rsl895178 CCATTGATCTTTAGCA[CZT]CTTTGTCTAAAATTAA rsl918026 GAGTGTTACGTGCTCC[AZG]AACTCCCCATGCTAGA rsl918422 AGGGAGGGTCAGAATG[CZT]CATAGCCTCCAGCTGC rsl920584 CATA I I I I I I GAATAA[GZT]GATATGTCCAGTGGTT rsl921589 ATGTAAAATCTGGAAC[CZT]GAACCATAGCAATGGC rsl924664 AATAAACAAATTAATA[CZT]CTTGAGCCTGTTACAG rsl926565 GCAGCCCTAAGAGCCA[CZT]GATCTTCCAGTTTGAT rsl933035 TTTAGGACTACTACAC[CZG]CATAATAGGCATTTAG rsl935115 GAAATGTGATTATACC[AZG]CAATCAGAGCTGAGAG rsl940745 CAGAGTCTTCTCAAAC[AZC]AAATTTGCATTCCAGG rsl94781 AGGCGCAATGATTTTA[CZT]GGTAGAGGTGCTTTTG rsl94782 CACACATGTATAGACA[CZG]ACATACAACCTTCCCA rsl956517 TGACAATATTGCCAAG[CZG]CTTGCTACTGAAATGT rsl957213 ACCCATACCTGATTTA[AZG]ATGAAGAGATTTGGGA rsl958234 TATAACAACGTAGTGA[AZG]ATAGAAGTTATGTGAA rsl960385 ACAGAAAACTTTTGGG [AZG]AATCCTGCTTTAAGGC rsl962196 TTTGAGCACTTTTGCA[CZT]TGAGAAAAACAACAAT rsl963296 CCTATCAATATTGCAA[GZT]CCTATTTTTAAGCCTG rsl963648 GCCTGGTTCAGATTCA[AZG]GAGGTGAGGAATCAGT rsl978718 AAGATAATGATAAGAA[CZT]GATGACTAATCTTAAC rsl979276 GCTCATCCATCTCTCA[AZG]GTGGGGGTCCTCCGGC rsl980408 TCCTCATGATCTTGCA[CZG]GACTTACAAATTAGCA rsl982747 ACTTTTGCTCATACTA[CZT]CTATTCAATCACTGGT rsl983294 CTCTGTATCCTCACAA[CZT]GACTAGGCCCCAGCTC rsl983535 CCTTGGACCAACTCGC[AZC]CAGGAAAGATGAAGTC

rsl99031 TTATTCCCTTATTCCA[C/G]TAATGCAAGGCTTAAT rsl990482 ATCAAATTCGATCAGA[C/T]CCAACCCCAAAGGTGG rsl995050 ACTGACTCTTTTGAAC[A/G]AAACATGCACAATAGA rsl996440 TCTGTCCAGCAACTCA[A/T]CCATCAGGTTTGAAAC rsl999800 CATATGGGCATGATGC[G/T]GAGTTTTGATGATCCA rs2012296 CATTAGTTCACTTATA[A/G]CAATGGCCTCTAGCTC rs2013265 TCACTCTGGGCTTTAC[A/G]AAATCATACAGACCTA rs2017914 AAATCATATTCCAAATlA/GJAGCATCAAAAATAATA rs2023120 GTTTCTCTTAAATCAAIA/G] AGTATGTACCTG ACAT rs2024476 AGGAATTTGAGGTAAGIA/CJCAATCAGGTAAAGTTC rs2026718 AGACTCCTTAATTAAA[C/G]ACTGTACTTACAGCAG rs2027714 ATAGGAATTTGTCTATIA/GIAAGAAATCACTGTATA rs2028100 CTTCAGAACTATGAAC[C/T]AGATAAACTπTATTA rs2029211 CACTTTATGGCACAGA[A/G]CTTGCATTGCTACCCT rs2031654 AGGAAATGTAGTTTCAIC/GIGAAAGGAATTTGACAC rs2033236 TGTAGGATTTTCGGGC[A/C]AAATGTGGGAAAACAG rs203948 TTTCAGACATGGTTGT[A/C]AAGAGTCAGCTCCTTG rs2048429 TGTTACTTTGAGTCGA[C/T]AGCCTCATTCACGACA rs2052815 ACTCTAC I I I I I I GGG[A/C]AATCTTGTTCTCTACT rs2053553 TTGATGCTATAGG ATG [A/G] ATTCCTTTGGCTCATG rs2059601 AATGTGTTATCAAGCA[C/T]GCAATCACTATGGGAG rs2061574 AAGGTGACATTGGAGqC/GJAAGACTTGAAGGAGAT rs2063807 TAAAACATTGTCAAAAIA/GJTTAGTAGAAGTCCACC rs2064947 CGGAGTGCTATTCTAA[C/T]GAGTGCTCCTCCAAGT rs2065903 GTAGAATTCAAGGCAT[A/G]AAGTAAAGAGACAATA rs2069112 GCTCCCTACAGTCTCC[A/G]GCATCAGTCTGTTCTC rs2073302 AGATGTCAGTGCAATAIC/TJAAGCCCGAAAGCAAGT rs2076355 TACAGCCTCCACAGGA[A/T]AAGACGGATGGAAGGT rs2079217 AGATTTGACATAGTAA[C/G]TGGCACTAACCCAGCT rs2090974 ACTATAAAAATTCTTG [A/G] AAACAATCTAGG AAAT rs2092096 CATTTGCAACATCATA[A/G]GTGAAACTGGAAGTCA rs2092101 GTACAAGGCAGTCAAA[C/T]CTGTTGACCTGCTGGC rs2096050 CAGGGTCGGCTTAAGC[A/G]ATTCTTAAACAAAATC rs2113025 CAACAGTCACCCAAGA[C/T]ATACTTACTCCTCAAA rs211831O GTCCAACAACAACTTC[A/G]GAAGATGGGAGCACAG rs2118838 GTTCACACAGTAGACA[C/G]TCCCAGAAGCATGAGA rs2134634 GAGAAAGAGAAGAAAA[A/G]TCGGAGAAACTGGCCA rs2136948 ATTGATTGGACATAGAIA/GJGGTAATGGAGAGAAGA rs2141991 GCTTπAACAAATCAG[G/T]ATACAACTTAGTATTT rs214511 CCCTGCACTACCTCAA[C/T]AATATACCACTGGCTG rs214742 TCTTCTTGTGCTTTAG[A/G]AGTCTTACGGCAAAAA rs2155647 CTAATAATGTATTTGGtA/GlAAGTTGTTCACATGGT rs2160974 TGCCAAATTGCCCTAC[A/G]AAGCTGCTGCAGGAAT rs2167769 TATTTAACTCCCTACC[A/T]AGTTCACTGTTAAGAA rs2171304 GCGTTAGAATTAGAGA[C/G]GAGCCTGTGACGCTTG rs2171965 TTTACTTAGTGAACCA[C/T]TGCATπTTGACAGTT rs2174308 ATTATCTCCCTGATGCIC/GJAATGCCTGATACAACC

rs2189192 GAGTTGTAGCATCCAA[A/ηGACCTTAATTAAAATT rs2190336 TATGTAACTGGTGGTAIA/GICTTTGAACTGGTAGGA rs2194390 AGCAATAATAAAGATGIA/GJAGAGTATCAGCTAAGA rs2194391 AGCAGCπAAGATCCA[A/G]TCAAAAAGACAAAATA rs2198552 AATAACAAAAGGTTTA[C/T]GGACTCAGAAAGGACA rs2207533 TCTATGTTGTGTAAAA[A/G]ACTACCCTGAATCTTA rs2208195 CTCTTCCTG G CACACC [A/G] C ATAATTCTTTTAAAT rs2212488 AGTGCCTCAAATCTCA[A/G]TACTAACGTTGAATAT rs2217889 CATGTACTATGGAAAA[A/C]ACCCATCTTATTACAT rs221871 TGTTTAAACTTATGCA[G/T]TCTTTGGGCCAGTCTT rs221873 AGTCACTGCACTAATG [C/T] AAAG G C AAG AAG AAC A rs221878 CCAAATG ATCTGCCAA[C/T]CCTCTGAATAACCAGC rs2219417 ACCTCACTG AATAATA[A/G]GTG ATAAGCCAAATAA rs2221112 GCTATTGGCCAACAGA[A/T]GTAGCTTTGACAACCT rs2224109 TTTTTATACCGAGCCA[A/G]GCTTGTTATGACTGTG rs2242926 CTCCAG ACCATTTGTG[A/C] ATTCTTG CTCTGAACA rs2246815 AATTGAAGTCAGAAAAIA/GITCCAATGGAGAATGAG rs2248225 TCGGTATGTGAGCAAAIC/TJGTTAAATGACATAGTG rs2248339 ATCCCAATACAGACTC[C/T]GACTAAGGCTTCCCTT rs2248564 AATGGCTCCATTTCTA[A/T]GAGAGGTAACTAAAAT rs2252538 TGAGTATACAGAAAGAlA/GjATTGATGAAAGCCAAA rs225549 AACAGTAATAGAACAAIA/GJTAAGAAGGTGGTTACA rs2260393 TCTCACTCTTTCCTCC[A/G]CAAACAGAGGAGTCTC rs2260817 ACCCTTGGAAGAGAGA[C/T]AAGACATAGTCCTAAA rs2261485 TGCTAAGCTTTTATAA[A/G]TGATGTCCTCTTATCA rs2267889 AACATACAGACTGAAA[A/C]TATATCTGCATATTGT rs2276674 TTTCCTG CG GTAAAAA [A/C] CAGAAAG CTAACTTGT rs2277418 TGCTTCAGAACTTACA[A/G]TGGTTTCTCATGACCT rs2281014 ATTGAGAAGCACATCA[C/T]TATTATTTGACATTAC rs2281672 GCGATGCCCTCGGAGA[C/T]GTGTGGCACACAGGAG rs2283092 AACAAAACATTCATCA[C/T]TCAGTATCCCCTTGTT rs2287192 GAGGAGTCAGTTAATAfC/TIGTGTAAAAGTTTTAGA rs2292343 CCTGGCTCTAAATTCC[C/G]CCGTATTTTGTAATCT rs2294208 GAAAACTGGAAAAAAA[A/G]TTTCCCTGCTGGAGTG rs2297330 GAGAAAAAGCCAGAAC[G/T]ACAACCCTCATCCCGC rs2298517 AAGTTGCTGTATTTAA[C/G]AATTAGCTAACCCTGG rs2299961 CCAATCTGATAGGTGA[A/G]AAAAAGCAGTGTACTT rs230157 ATGCTGTGTTTTCCAC[A/G]ATACTGGTACTACCGG rs2304496 CCTCAGTGGCTGAAGA[G/T]CTATGTCCAGGGAGCA rs2310047 GCATAAGGAAATCAATfC/GlAAGGTGTGAAGACAAT rs2312150 GGTACTTGACTCCAGA[A/T]GACTACAGTGATAATT rs2316310 TTAATGTACTAACCAC[C/T]GGGGAAGTGCAAATTA rs2318149 TTTGCAGCTACATACA[C/T]AGGGTCAGAGAATGTT rs2319227 TAATCAAAACTGTATG[A/G]CACTGGCATAAAGAGA rs2319231 CCCACTACTGAAGGAA[A/G]GGGGAGTATACCGTAT rs2327351 AAATGCTTCCAGTCAC[A/G]CTGAACTGAAATATCT rs2328391 TAACTTCAGAAGGCAG[C/G]ACCTTGGAGGGGAGCC

rs2342435 TGGCCTTAAGGATCTT[C/G]AAAATATCCCCTTCCC rs2345589 TTGATGCTTAGACCAA[A/G]AAATTCTTAAGATGTA rs2349251 GGCGGCTCTGACCTCC[C/G]GATGCGTTTCTCCAGG rs2351044 CTGATGTTGACAATGCfA/GlATGGGATTAAGAGGTG rs2358766 ACATCCCCCAAAGCAA[A/G]GTATTAAAATGATTGT rs2369522 AGGATGCAAATTTCAA[A/C]TATCTGTTATCCCTTG rs2370413 CCCTTTGACAGCAAAA[C/T]CTGGCCTTTCCTGAAT rs2370919 AGAA I I I C I I ACCGAT[C/T]AGTCTCTGGCCTCTTT rs2380426 TTCCTACCTGTCAGAAIC/TIGGCAAAGGTCAAAATA rs2389316 GGCTCCTCGTTGAAGTIC/TIACCTCAAGCAGCCTGA rs2397989 CGCTGCTCCTCATAGA[C/T]GTACTACCAACCACTG rs2399308 TATTCTACTTCG CTTA [A/T] CAAC ATAAGTTCC AAT rs2400000 CAGTCTACTATATGAClA/GlAAAGCACAAATAAACT rs2403054 TTTGGGAGAAAACACTtA/GjAGAGTTGACAGAGAGG rs2403123 TGAGAACTGATGAACAIC/GJAAGGAAACAATAGACA rs2403123 TGAGAACTGATGAACAIC/GJAAGGAAACAATAGACA rs2408467 CACATGACCCGCTAAC[A/G]ATTCTTCTATCTTTTA rs241218 CGCACCAG AG AAAAAC [A/G JCCCAG AG AAGTGGCAA rs2412586 TGGCTCTTTCAAATCT[A/T]AATGACATTTATGGTC rs2419533 TCCATCTCTTAAGCCA[C/T]GAGAGGAGACAGATTT rs2419620 CTGTTTTTGTTTAGTA[A/T]TGATGCCTTGCAGTCC rs2425520 AGTATGTACTTAAGCT[C/G]AAGTCTCATCATTGAT rs2430988 AGAAGGATAATGAAGG[G/T]CCTCCTTAATCAGAGT rs2435242 CCCTACCTTGATCTAC[A/G]GATTCATTGAGCTCTA rs243839 AGTCTGAGTTTAATCA[C/T]CCTGCAATACTGTCCT rs244097 TTTCAATTTCCCCGAA[C/T]GAGCTGGCCTTAATGA rs244098 GGATGTATGATCTAAA[C/T]TTGCCGAGGCTCAGCT rs244104 ATGAATCTGAACTTTA[C/T]CCTGATGGCTCTGAAT rs2449818 CTCTAATGATGTAAAA[C/G]GCCTCAGACATCGTTA rs2452461 TTTAGGCCTAGTTTAA[C/G]CAGATCTTTAAGAGAC rs2452463 TGGTTTTGTACTTTCA[C/T]GTTCAATTCCATTGAC rs2452464 CTAATCCCAGCACG AG [G/T] ACTGCACTTAAAGCCC rs2466848 CAAATTGAAAGCTGAA[C/T]CCAGTGATTAGAGAGG rs2479373 TCCCCCCAGCCCAAAC[C/T]GACAAACCGAGATTTT rs2482496 CATCCTTTGGGAATGA[C/G]TAGATCAAAGTAAGAG rs2492803 GGTAGATTAAGTGTGCfA/ClAAAAGTTAAATTTAAA rs2499796 TAAACATAGCATGGAA[A/G]AAAGCTCCTCTTTACC rs2499797 ACAGAATGCTTAAACC[C/T]CATGCACTTAATAAAA rs250578 CAAGGAGAACAGGGTA[C/T]GCAGGAAAGGCAGGTG rs250583 AGATGTCTGAGCTTCA[A/G]CCCGGTCTTGCTAAGT rs2513922 AGCAGACAACGTGGCA[C/T]AGGC I I I I I I I AAATT rs251684 GGACACTACCCTACCC[A/G]ATATTTGCAGCCATTG rs2527031 GAAAAACTATCCTTCG[C/T]CATGGTGTCAGGTAAT rs2528632 ATTCACTGAAGTGTGA[C/T]GGCGGGGAGTGGAGCT rs254287 CACAGTGCATTATCAA[A/C]C I I I I I I I AGACGGGG rs2544995 TTTGCAGATGATAAAAIA/TlTGAGCTTTATAGAGAC rs2545618 ACCCAACTCCAAATCA[C/T]GTTCCAATTGTTACTG

rs2554622 ATAACTAACTATAAAA[A/C]CCAGCATCTAACATAA rs256514 ACATA I I I I I l I GGAG [A/G] AAG ACAATTCAATCTG rs2565142 CAGAGTGAGGAAGTAA[C/T]GTCTACAGGGCATTTG rs2568491 TGTGATCCATTGTATC[CZT]AGCTCACCTGTTGTTT rs2573625 CTCCCTGATTTCAGAC[A/G]GAAGGTCTCACTTGGA rs2577592 AAGGCTGCTCATTTGA[C/T]GGATGAATTACTCCAT rs2581345 AAAGCGAGTCAAGACA[A/G]GAACACTAAATGATGT rs2585512 ATCAAAAGAAGGCAAA[A/G]TACTCTCATTTTTGTG rs2585669 CAATTTACCGTGTGGC[A/G]AGACCATTTCCTATCC rs2586949 TTTCATGAAAACCAAA[A/C]TTGAGTTGTTGACTAT rs2590260 ACTATGGTATTAGAAA[C/T]GCTAACTACAGAGATG rs2596929 TTGGTGGTACTCTACA[C/T]ACATGGCTGCAAATAG rs2597519 TACGAAACTGCCCCTA[A/C]GCTGCTACCCTCTGCA rs2600998 CTTGATCCCAAAAAGA[AZC]CTTTCATCATGGAACT rs2602707 GTCAGGGGTTCTCAAA[C/T]GGATTTCAGGACCCTT rs2618162 GTTGTGGGTCGAACAA[CZT]TAAACACCTCACTCTG rs2623069 TGCTTTACAAAAGACA[C/T]TGTCAGGAGAATCAAG rs2631709 TCCACTCC ATATCATC [G/T] G AATCCC AACATTAAA rs2632188 GAATGGAGCCCCATCA[C/T]GTGCGTTTTAACAGTC rs2638504 TGCCTGATACAGAAGA[C/G]AAAGTTGCATAGGACT rs2640485 TGCAGGCCATTGTAAA[A/C]AAGCCTTTAGTTAGTA rs2645778 TTAGGAAGGCTTTGCAlC/ηTGATAGGAAGTAATTG rs2647442 CTTTCCTCTGTCTTCC[CZT]CATTTCTGCTACTGGG

γS2652148 GGTAGGACATTGCTTA[AZG]CTTCAGTGAATCCACA rs2664124 ACTTTGTATTCAGAGA[CZG]ATTACCTATAAGCAGA rs2667406 ATCATCTGAGAAAAAA[AZG]TATAGACCCAGAACAA rs2669438 TTTAGCTTGTCTTAAT[AZT]AAGTTTACGTCTATTT rs2679749 TTATAAAAACATCAGG [CZT]CCACTGG ATCAAGTCT rs2679752 CTACTTAAACTGCCAG[CZT]CAGTGGAATAAGGACT rs2679754 TTGCTCTATTGGACAC[CZT]GAAATCCTGGGGTTAA rs2682295 AGATGCTCCAGAGTAA[AZC]TGTATAGACCCTCCCC rs2683690 CAAAATCATGGCTCCA[CZT]CTCTGTGATATTTTGA rs268387 CAATGACGGCCCTTAA[CZT]TGAAGTGCACACTAAA rs268599 AACTCACCAAAATTGG[GZT]AAATAGAAAGCATTTT rs2699749 GACACTAGACATTGGG[AZT]ATGAACAGACATCAGG rs2706364 CAAATATTACTGTTTG [CZT]ATCCAACAAGAGAAAA rs2714050 TACAGCAGGAGGGATT[AZT]AAGTCATCCTAGTTCC rs2715654 AAACTGATGATGATGA[AZG]GGATAACAATAATGGT rs2726164 TAAACCAGG I I I I I CT[CZG]ACTCTAGAGACCATGT rs2730306 GGGTCAGCGACACAGA[CZT]GGACTTCCGTGGCTAC rs2732248 GAATTTCGATACTGAA[AZG]GGCTAAATGTACACTT rs2738078 GCTCTGATGTGGCCAC[CZT]GTGATTAACGCAATCA rs2738079 TTCTGTTCCACAAGCT[AZC]AGAGGAAGCAGAATTT rs2794515 AGGAAGTGCTACTTCA[CZT]GTATTTGTGAGAGTTT rs2806735 GTACGGCAGAACAGGG[AZG]AGAGATAAACTCTGGT rs280983 AATAGATTAAAATGAA[CZT]GTCAGAAGACTATTTC rs280984 GATAGCTGTTGTATAA[AZG]TGAGAAACAGGGTTAT

rs2810740 CTCCCCATCAAGCACA[G/T]TCAGCTCATAAGTGAA rs2814689 AAGGAACACTTACGCA[C/T]GGTTGATGGGAATGTA rs2815143 ATGAAGTACCCTTATC[A/G]CATTACATCAGTGGGT rs2815167 GCTACTAGGAAAAAGA[A/G]ACCATCTTCAGGCTGT rs2815385 GTTACAGACTTTTAGA[A/G]CTTGTTTCTGTAGGAC rs2815792 TTAGGCAAATCTCCAC[A/G]AAGGGCTGTATTTTCC rs2829267 TACGTAGAAGGCTGTC[C/T]C I I I I I ATCATTTATT rs2829290 TATTAACTTAAACACC[A/G]ATTTGCTCAAATTTCT rs2829819 CCTAAGAATTGTGAAAtA/GITTTACTGATTAGAATT rs2838873 ACGACACATGTTTAAA[C/T]GGCATTCTGTGAGCCC rs2839580 TTGCATCTTTGGGTTA[A/C]GGCTCTGCTGCCCTTG rs28490018 TCATCTGTG AATGAAG [A/G] ATGTCAATATTCAGGA rs2849395 CTCTGGTCTCCCACAA[A/T]CCTGAGCTGCCTCCAG rs2849463 AGTGGTGCCTGCTTAC[C/T]GAATCTGAGAAGGTTA rs2850935 GTGGTACTG ATTGCTG tA/C]AATTTGGTCAATG AAG rs2851911 AAATCCTTTCAAATGC[A/G]AAAG I I I I I CCAAACC rs2851911 AAATCCTTTCAAATGC[A/G]AAAG I I I I I CCAAACC rs2851912 GCCTCCAGTCACACAA[A/G]CCTGCTAATCCGTGAC rs2863200 TCTATGCATTCTTGGC[A/G]AATCCCTCAACATTTT rs2894058 AATGTTATAGTAGTTTIC/TJAAAAGCATTTGGTCAA rs2894324 GGTGATGGTCCCAGGA[A/G]AGAATGGTGAGCAGCA rs2912020 TTTGCTAAAAGTCTTC[A/G]AAAGATTTGCCAAGTT rs291550 TTTTAAATGGAAAAAA[A/G]TATAGCACTTACCTGT rs2926095 AGTGTACTGCTGATGA[C/T]GAGAAGGAACTAAGGA rs2926110 AG ACTCAAAAG ACATG [A/G] ATG ATCCAAATATGAC rs2935260 TTCTCCACTGGTAAAC[A/T]CTTAGTCTCTGTCTCA rs2936534 TCCATAGAATTACTAA[A/G]CAGCTCCTCATAGTTT rs2936535 AGCACTTTGCTCTTCC[G/T]CACCAATGCAGTACAG rs2942884 TAGTG I I I I I GTCTCA[C/T]GGGCTAATGTCAAAGG rs2956830 GCTGG ATG CATTAACG [C/T] AAAGTG AATATACCTG rs2960744 TGTTTTCATTATGCTA[A/T]GTACAAGATTGTGCTA rs30012 TAACTCCTAAGGAATA[A/G]AGGCATCAGCCATACC rs301163 TCTCTTGATGCTGTTA[C/T]AAGCCGCCCGTTTTCA rs301164 TAGCGTTTTCTCCAGA[A/G]GCATGATACCAAGCAT rs301583 AGGTTAAGTGATCAAA[C/T]TGTAAATACATCCCAA rs3019442 TGCATTAAAATCTGTA[C/G]CAGGAATCACTTCTGC rs303765 AACCAAGAAGCACTCA[A/G]TACATGCTCCATACAT rs30751 TTC I I I I I I I CTCATC [C/T] C AAGTCTTC AAACTCC rs3091251 AGCCTTACCTGAAGAA[A/G]GGTGTGCAGTATGCAT rs3091252 GCGTGACCAGGTAGAA[C/T]TAGCCTCAGCATGGAA rs3096130 TAACATTTGGTATTAAIA/GlATATGTTCTGGCATGG rs3104704 CTGTACATTAATACCC[C/T]AAGAGGCAATGTAAGG rs3112257 GGAAGTCAAGATGAACIG/ηAAGGTTGGCTGTAAAT rs3124516 TGAGAAAGGTACTGTA[A/C]ATTCTAAACTTATGCC rs3128625 CCCACCACTCCACAAC[A/G]AGCCACTAGGAGTTTC rs317147 AGACTAGTTATCTTAC[C/T]CATCTCTTACAACTGG rs317155 AATTTTCCTTTCTCAG[C/T]CGTCTTCTACCTCCAG

rs317174 GTCACCCTGTGAAAAA[A/C]CACCCATATTCTTTCT rs318860 ATGTAAGTGTGAAATAfC/TlGCTTCTTTGGAAGGAA rs319011 TAAGACCCCTTCAACA[A/G]TGAATGATAACACAGA rs330581 GCACCAAACATTGAAC[C/G]AGTATCCACTTCGAAA rs330582 TGAACGCCTTTAAGAA[A/G]TGGTCCCTGGCTGCCC rs331742 TAAAACATπTAACCC[C/G]ATCTATGTπTAAATT rs331783 AAAGGGATATAATAGAIC/GJAGAAATGGTTGAAAAA rs333531 GCTCTCTGTAGCACAA[C/T]AGTTAAGTAAGCACAC rs33612 TTTAAAAAACATCCCA[C/T]TGACTACAAATGGATG rs33762 CAGGTTTATTGAGGAAIG/TJAATTGGTATACAAATA rs33978605 AGAGATTTGTTTTTCC[A/G]GCCATCTATAGAGATT rs34266279 GCAGCATGCGGTCCAA[A/C]GTAATAAACAGATGTC rs34795027 GTTCTTTG AATG AAAG [C/T] AG AAATG ATCGCTAAC rs34799743 TATGGTTTTTATATTC[C/G]ATACTCTCAGGTACAG rs351737 TGTTCTGTGAGTGTTA[C/T]CAGCACTCTGGATTCT rs35471 AAGCAGAGATTGGACC[A/G]GAAACACTCTTGGATT rs35662693 GAAATTGGGG ATTG AG [A/G] AGATTGG ATCTTAAAA rs36017 ATCTGGGGAGATTCCA[C/G]GCTCATGGCTGCTTTT rs367719 AGTATTTTTGTCGTCA[C/T]GTTAGGGTCAGCAAAT rs3734281 TCTGGG AAGACCGGAG [A/G] AG AG AGACCTATGGTG rs3737845 TGTGTTACTATGCGAC[A/G]AGTACTGCTCACCGCC rs3741599 AAGAAACAAGAGACAA[C/T]TATATGAGTGACTTAA rs3753151 CGGTCATAGAGGTTTC[C/T]AAAATTTGGTGTTCAC rs3757971 AAGCAGTGCTGGCTCA[C/T]ATACACTAGCTGCAGG rs3773383 TATCGTGCTTAACAAA[A/G]GTAATGGGGACTGTTC rs3775580 ATTTGGTG ATGACCTG [A/G] AG ATAAACATTTGG AA rs3779258 TCAGTCTCTAAAGTAAIC/TJCAAGTCAATTCACTAT rs3780473 CATGAGCAAGGGTGAA[C/T]TCAGTGTTATCATAGA rs3780474 CTTGCAGAGATACTTA[G/T]GCTTTTGTTAAGAATT rs3780474 CTTGCAGAGATACTTA[G/T]GCTπTGTTAAGAATT rs3781571 CTATTGTTAAGCAGTA[C/T]AAGACAGGTCTCTTAA rs3785157 TACCTCTAATGCACTC[C/T]GAGGACCCCAAGCTTT rs3811924 TTACTGAGTTCTAATAtA/GJGTGATTGGCAAAGGAA rs3820821 GTCAAGTCTGAACCTC[A/G]CATTTTCTCCCATCTG rs3821374 GCTCCCATCCTAAACA[C/T]GCACAACCTGAAAGAG rs383659 TTTCTGAGGATTAACC[G/T]AAGCAA I I I I I ACCAG rs3844462 CTTCTATTCCCTCACT[C/T]AGTAGTCAACACAGAA rs3846820 CAAAATTCTAAAATAT[A/T]AGAGTGCAGTTGTCAT rs3848771 ATATTCTTAACACTTA[A/G]AGACTCTCACAAACCA rs3848774 ATGAACATGGCTTGAA[C/T]GCTAGATACTGGAGTT rs3860187 AAAGGGTTGGAGGTCAIA/GIGGAAGCCGTCTCTAGA rs3861988 TGGAAGTATTTGCATGIA/GJCATAATGCAGAATAGG rs3862501 ACATAGAAACGGCTAA[C/G]CAGTAGATATTTTCAG rs3883317 GGAAGAGTCCAAATGT[C/T]AAATATGGTTCCAGGA rs3909441 GTAATGTGTCTGTTTA[C/G]ACCTTCTGCCCATTTT rs39095 AGCAAAACAACAATCA[C/T]GCAACCCCCAAATCCT rs3910518 TATATTCAAAATAGAAfA/GlTGAGCTGAATTAGAAC

rs3914604 GAGAACATTTAGCTCA[A/G]GTCTAATAGCAGTTAT rs3917768 GCCAAAATTTGGGCGC[A/C]GATTCCACCACTTGGT rs3920081 TACTGACTATAAGATA[C/T]ATTTTGCCAGAATGAA rs3924188 ATTCAGTCACAAGTTA[AZC]GGTCTCAAGGACATAA rs3930757 GGGTTTTCTGGGCTAA[G/T]AGTGGACCCACTGCAG rs3977736 TTTTGAATCTCAAACC[A/G]C I I L I I GTCTTCTCCC rs3980634 TTGTTTTGTATCATGG [A/C] AAATCCTG ACAACATG rs3995971 ATGTAACTGTGGCTAA[C/T]L I I I C I I ACTCTGATA rs4008332 GTTAACAACAACATAA[A/G]ATAACTGTGAGACTAA rs4027132 CAAATTCAAAGTTCAA[A/G]TCGTATTTCTGGCTAA rs4061929 GGAGTTGAGCAAGAAA[C/G]AAAAGATCCAGGATAG rs4078038 GACATAGCTCTGAGTT[A/G]AAAGAGTGACAGCGAA rs407929 GGCCTTTGAGAATTGC[A/G]GAAGGAGCCCACTGGG rs4085410 CTGTTCTGGCTCTGTA[A/G]GAACACTAGACTTTGC rs4130030 TTTTCTATGGTTTGAA[C/G]TCTTGGTAATTACCTC rs4135067 AAMTAAAGAGGAAAA[AZC]TAATCTGAACTTTTAT rs4141410 AAG AATTATATCATTG [A/G] ATTATTACTG AGCAG A rs414161 GTTATTCAAGTTGGAA[AZG]TATTTGCATTATCTTT rs4142730 CTGGAGGCTTTCCAAA[C/T]GCTTCTCTGACCTGAC rs4234177 TAATCTATTGCTCCAA[A/T]TGACCGGCTGCCTAGA rs4236721 GGTTCATTTTCCTGCC[C/T]GCTATGTGTTAGTGAA rs4238859 TGGTGGTTTGTGCAGC[AZG]ATAAATTAAAAGGCAT rs4238998 GATAGTACCAACTTCA[A/T]GAGGATTGCTGTGCTC rs4239268 CTCCTCGTAGTACAGA[C/T]TAATTTTCAAAATAGT rs4239307 TTACATATCAGTTGCTIA/GIAGAATATCTTCTTCCA rs424301 AG AGTGTGCGCTCAAG[C/T] AGGAAAG AAGTAGCAT rs4243177 GTTTAGAGGCGCCAGA[A/G]AAAGGGTGAACAGGGA rs4244842 GAGGTTATGGCATGCA[CZG]AATTAGAACATCCATG rs4272068 TGTGCCTCCTGGGATA[C/T]AGTGTGTCAGGTTCAT rs4275832 AACTGTTAGAAACATAlC/TlACAAACAGGCCTCTTA rs4277177 GGGGGTTGGATAATTC[AZG]CTGGTGGCAAGGAGCA rs4293434 TATAAAAGTAATTGAC[AZG]ACTCTGGGTGATTAAG rs4296321 CAGTGCCATAGGAAGA[AZT]GTGCTCAAGAAGCGTG rs4298502 TCAATGCCTCTTCCAA[AZG]CACTTCTAACCAACCT rs430208 AAGATnTTAAGCAGC[AZG]GAGTAACATGGTTCAG rs4302323 AGGGTTGGTTTTAGTC[AZG]CACCTCATGGCCCACC rs4310272 ATGTTTTAGGACCTGA[AZT]AAGTGTATTATATTTA rs4316363 CACACATACGGTAAAA[AZG]TAATTAGAGAGGACCT rs4319862 TCAAGGAATGAGCAAG[GZT]CTATGTTCTGTGGGGA rs4341081 AGGCTGGGGACTAGTG[CZG]ATCATCGCTTAGGATT rs4342050 ATCATG CTTTTTAATG [CZT]AGGGCTTCCATGGTAG rs4359861 GAAACCCAAGCCCAAC[GZT]CTGTCACTTCCATCTA rs4361034 CCATTAAATAATTACA[AZG]GCTGCGTGAGAGAGCT rs436760 ACTGCTTCCTCACTGA[CZT]CCATTG I I I I I I GGAT rs4370836 TGATTGTCTTTCAACA[GZT]ACCATGTGTTTCTTTA rs4380234 TGAATCTCAAAAATGG[AZT]ATGATGGGCAAAAGGA rs4381693 GCAGCCATTGACAATA[CZT]GTAACAAATGGACATG

rs4381975 TCTCCTTTG I I I I I I A[A/G]ATGGAAGCTTACAGTA rs4382808 GTTTAAGCGACAGTGAIC/TIGGTTGGATTGTAGTTT rs4406411 AGGAAATATTTGAGGAtA/GlGTTTGAATATAGCCCT rs4413045 CTAATTAGTAATCTCC[A/G]AAGACTCTCACGTTTT rs4427899 TGGCTTCCAATTTTCC[A/T]CTGTAAAAATTATCTG rs4432914 CAC ATCAATTC AAAC A [C/T] CATTCCC ATCTCCTTT rs4438317 TATTCAGAAATCCATA[C/G]ATTGTGTTTGCCTTTT rs4444654 GTCTTGTTCCTAAATCIC/TICCATTTGACAGATTGT rs4447477 AAGTATAAACACAATC[C/T]ATCTCTCTTCAAAGCA rs4460614 ATACAAAAAGGGAAAGIC/ηATGAGAGGCTGTTTTA rs4471623 AATTGTCAATGAATCA[C/T]AAAACCTAAGGCATTC rs4497423 TGTAGTTAGAACTAAAIA/GJATTGAAGATAGGAGCA rs4509857 TATATGATAAAGTCAC[C/T]GTCCTCTTTCAAAGTC rs452707 CTG AAATGCTAAGCTG [A/G] AACTAG AGTCTAACAT rs4528272 CAAAGATATTCAGGAA[A/C]CAACAAGGTAAAATTT rs4531484 CAAATGAGTGTTGTGC[A/C]CTTAAGGAAATTGGCT rs453572 CAAAGACCTACCAAAA[C/G]ATGGATGATTCTGAAA rs4538346 GTCATAAAAATTGTGA[C/T]GAACCACATGAGGAGC rs4554206 GGGATTACAGGTATGC[A/G]CTGGCTAACTTTTGTA rs4560339 ACTCATACGTTCAGCA[G/T]TACACCATTCACAATA rs4561871 GCCCTGTCTACCTTTC[C/G]AATTCCACGTTCCTGT rs4594180 TTTTTCTAAAAAAGTA[A/G]ACTTCTGCAGCATCTC rs4603984 TG CTTCCC AG AATC AG [G/T] AAAATTATTAGTTGTT rs4610242 AGCCTTCAAG ATTCGG [A/G] ACACAATAAGG ATGCC rs4610413 ATTAGGATTTAGCTACIA/GIGAAAATGGCTATGAGA rs4614822 ATGTTTGAATACCCTGIG/TICAGAGAGAGATTTCCA rs4620015 CGTATATTCCCAGAAA[A/T]GAGTGACCGGAACAGT rs4635681 GTTAGTTTACTGGACC[A/G]ACAGAGGTGATTTCCC rs4645337 CTGCAACAACAGAATA[C/G]TAATGCACTGTCATGA rs4645933 GTTGACCTGGTGAAGA[C/T]ACAGAGGCTTTACCTG rs4654534 GCAGGTGTCTCCACAT[A/T]AGAAGCATCCTATGTA rs4655625 TGGCTTCACACTAGCA[C/T]ATTTGTTTCCTCATTC rs4655641 CTCATAGGTCAAGTTA[C/T]AGGAAGTAAAGCACTT rs4658439 CAGCTTACACTGGCCA[C/T]GTGGTATCTTGATGAA rs4663955 TCATTTCTCTGCTTAC[A/G]GGGCCGACTCGTTCCT rs4664865 TGGTCCCAGGGTATTA[G/T]GAGGCTCTCTGAAGTT rs4665969 CTGTATCAAGCCACTA[C/T]CCCTTGATCTCTCCAA rs4669342 TGCCACCATCCAAAAA[A/G]TGACATATTGTTCACT rs4673823 ATTAAGGACATGGAGA[A/C]GAGTGACTCAATAGTA rs4676814 TTCATGTTAAATAAAA[C/T]GTAGCAATGATAGTCA rs4677304 TGTGAAGAGGGCTGTC[A/C]AGACAGGAGCTGTGCA rs4679840 AAGGATATTTGGACAC[A/G]CTTAATATCTTTTGGA rs4689651 CCAGCGGAACCAGAGA[C/G]CGCCGTAGTGACCTTC rs4693142 AGATGGGTAGTTATGAIC/TICTGCACTCTAGCTAAG rs4693571 GAAGAGATGTGGGGGCIA/GIGAAAGACAGGAAATAG rs4702266 TAGTGAGGCTCACAGC[A/G]AGTTAGGTAGATGGGA rs4705283 CAG ATGG AG AACCTGG [A/C] CCAAG AAAG AG AGAGG

rs4705698 CGGCAACATCTGGGAA[A/C]CTGTCGGAAGTGCACA rs4705710 CATAACATCATTGGAA[C/T]ATACCTGTGAGTGAAG rs470588 TTCATCTGAATCTCCT[C/T]AGATGTCCCTCCGTGT rs4710333 CTGAGTATCTAACCAT[A/G]AAACTAGAGGTGGAGT rs4711764 CCAGCTTAAGCAGTTA[C/T]AGACATCATAGAATAT rs4713899 CATCTGCATCTGTTAC[C/T]GCAATCAGGGCCCCTA rs4715939 TTACACGAGCTCTTTC[A/C]ATCTCTTTATCATAAC

TS4719813 GAATAGCATT7TGTTA[A/G]GGTCAGAATTTTCCAG rs4737321 AGAAAATCGCGTAAGA[A/T]GTCAATATGCTGTTTA rs4750480 GTACTAGCTCTCCTTA[C/G]GCTTAGGGTGGTAGAT rs4761127 TCTCCTTGTAATTTTC[C/T]ACTGATACATGAGCTT rs4761350 TAACAGCTTAGAGGAC[A/C]GATGATGGTGTCAGAT rs4765033 GGTGAAAGGAACTATC[C/T]ATCCCGGACTTTGTTC rs4766591 AACTTGAACCATTAAA[C/T]TAGAACCCTCCAGGGC rs4766601 GAGAAGCATATTAGCA[C/G]TGACCTAAATGGCCAT rs4766691 ACTGAGCTTAGCAATC[C/T]CCAACGTATTGATTTT rs4766720 GTGGG ACAGCTGTTTG [C/T] ACTTAG CAGTTAAGTG rs476838 TTCATGTGTTATAATG [A/G] ATGTTACCGATGG ATT rs4769856 GTTGAAGATACAAACA[A/G]ACCCTCTATAATCCTC rs4771651 TGGCGGGCAACTGGGA[C/T]GAGCAAGTTTCTTTGC rs4775276 ACTATCTTAAGTGCAC[C/T]GAATAATCAACACCAG rs4785325 AATATCATTCCATCAA[A/G]CTAAATTTTTAACTAC rs4788933 GGCAGTAGAGCACTTA[A/G]GAGAGGGGACTCCAAA rs4797877 GATACACAGATTGTCA[C/T]TAGGTTATCTTCTGTA rs480039 GCTTAAGCAAAAAGGC[A/G]ATTTACTAGAAAGATA rs4801417 AAAAAAAATTGCACAA[A/T]CACACGGATATAGGGA rs4810366 AACATTTGAATTAACA[A/G]TCCTTGCTGTGTGTGT rs4812631 CTGACCATTTCCTTAC[C/T]GGTTATCTTCCTTTCG rs4832333 CTTTTATGACCTTAAA[C/T]TCCTATGCACTAACTG rs4839826 AGATAACCTCCCATGC[A/G]AAATGAGTAGGTTTTA rs4842244 GGAGCGACCAGGGTAC[C/T]GACACCATCTTCTCGA rs4849143 ATGAGCTGATCTTTTG [C/G]ATTGATGAATCACCCC rs4850945 TCATGACTGTGCTGAA[A/T]GGGAAGAAAAGTGTTC rs4851365 GTGATGAGCTGCTTCC[C/T]CCACGATTTCACTCAA rs4851422 ATCACACAGGTAATAA[C/T]TGGTCCATTGTGAGCC rs4856502 GGGCAAGGAATAGCCA[A/G]TCTTTAAACAGAATCT rs4857242 TATTTGAAGACTTAGG[A/C]AGCCTCTGCTAGGCAT rs4866542 CTTAAGCATGGCTGAA[C/T]GTCCAGAGAACATTTC rs4869544 ATCGTTCCAGTCTTAG [C/T] ATATGTG CTG CCAAAG rs4870752 AAAAGGGAACAAACTA[C/T]GCCACTACCTTATCAG rs4876626 AAATCTTGTTATGTAG [A/T] ATCG AATCATGTG AAA rs4878520 CAGAGCATAAAAGAAA[C/T]AGACATACACACAGAT rs488131 CGAAAAACTGCAACAT[C/T]AGCTGGGCGTGGCAGC rs4905157 GACTACATCCTTATAA[A/T]CTGCCTCAGGAAGCAA rs490767 CTGTTTGACTTCAAGG [C/T]CAGG ATCCCGTTTTCC rs4910325 TCGTGGGAGCTTGTCA[C/T]ATACAGCATCTCTTTT rs4920424 TGTGGGCAAGTCACAC[A/T]CATGCAAATATGTGAG

rs493490 CCCCTGAAAACTGGTA[C/T]GAGACAAGAATGCCCA rs4937159 AAAAATAATAAGCCTA[C/T]CTTATCTCTCTACATG rs4938648 AGCTTTATCTGTATCC[A/G]AACAGAGGGGAATAAA rs4940533 TGCTGCCGGTTGCATA[A/G]GAGTCTAGCACACACA rs4941312 ATGGCTCAATGTGACA[A/T]CCCTTACAAAAGCAAG rs4943980 TCCTTCCTTTTTTTCA[A/G]CAAAGTGAGATGCAGA rs4952521 TGCATCCAAGGGCTGA[C/T]GAATATTTGCAACACC rs4968008 CAAATAAGCAACTTAC[G/T]GAAGGTCATGTGAαC rs4968013 TCCAATTAGTAGGACA[A/C]AGAGCGATGCTACCAT rs4982731 AATGTGGCTCACCCTA[C/T]CTTGCTGGTCTGAGGG rs4995246 GACAAGGGAAAGTTCC[A/C]AGAAGAGTGATACCTC rs500397 ACATACTCGGTGAATG[AZG]CAGATAGCTCCCACTT rs509759 TGATAGCACCAGAGAC[A/G]AAAAAAGTGCCAGGGG rs518647 AGATAAGAAAGCAAAG[C/G]CCAAGTCTCATAGCTG rs522030 GAAATGGGAACACAAT[GZT]ATATAAACTACAGTCC rs522740 TGATGGGCCTGAGATC[A/G]ACTTCAGTGATGGGGA rs528484 CAAGTAAG ATAATATG [A/G] ATTTG AC ACCCCAAC A rs529423 TTGCAAAGCTCCACGA[A/G]GCAAGTGAGTCGCCTA rs529584 TGGAAGTCACAAAATA[C/T]CTAACCTGGGGGCCAT rs549466 CACTAGGTTGTAGTAA[C/T]ATTTGTATAACATGGC rs558582 AGAAGAGGTGTGACAA[A/G]CGACTGGCACACAGCA rs566164 CATTGTGTTTTCTCAA[CZT]GATTCAACCTAACAGG rs566817 ATAAATATGAAAAAAA[CZT]TGAATGTGGCAATTAA rs568682 GAG ATCTG ATTTTGTG [C/T] ATGCTTG AATCCCTGT rs569694 CTTTTCCTTATCCAGC[A/G]ATGACTTACCTCTTAC rs5742878 GTATCTTATAAGTCAA[A/C]ACATACATAACCCCCA rs5765397 TTGCAACTAAGAGTCA[C/T]GATTGGCCGGGCACAG rs5765398 TTTGGTAGCTCATAAA[A/T]TCATCAGGAATACTGC rs5765425 CAACACCACGTGCAAA[AZG]ACCGATGCAGACTTGT rs584125 AATGTTACAGGGAGAG[A/G]AATGAAGTGGAGTTGC rs589540 TGCCACACATCTGGCA[CZT]GGAGCCAAGGCAGAAG rs601305 TCCTGAAACATCAGCA[A/C]CACATGGTATTGTAGC rs6014814 ATTAGAGACTGGGCCA[A/G]CTGAGTAGCCACAGGG rs6016864 GTGTTAAAGTACCAAAIA/GIGCTCCAATTTACTAAG rs6031659 AAAATGGCTACCAGCAIC/^AGATGAAACAAAACTG rs6032919 TTCCAGAAGTATCTGG[GZT]AGTTTACATAGCCAAT rs6040171 CACTTATGGCTCTCGG[AZC]AAGTAAAGCATCTCCA rs6041841 GTCTGTTTCCTAAGAA[AZG]GACAATGATAATGAAC rs6062419 TGGTTTCTACTCTGAA[CZT]GCTCCTGAACAGCCCT rs6062419 TGGTTTCTACTCTGAA[CZT]GCTCCTGAACAGCCCT rs6065525 TGATTAAACTTTCTAC[AZG]ATTTATGCGCAACACT rs6069858 GCTGGAAGAATTCAGA[AZG]GAAGATGCTAGAAAAG rs6069864 TTCCACTTCAGCTGTC[AZG]ATCATACACTTGCCCA rs6072819 ACTTAAATGCACCAAC[AZG]ATTGGAGAGTAGTTAA rs607985 TCGGTGTGCCTGTGAA[AZG]CTTGGGGATCTTGTTA rs6080358 TCAGAGCTTGGCTGAA[AZG]TCTGAACCCCAGCTGC rs6085468 AAATAGCTTCTGAAGA[CZT]GAAGGTAGAATAAATA

rs6089599 TCCTGGGAACAGTAAC[A/G]CCCCAGTAACACTGAG rs6093764 CAACTTACAGATATAC[A/G]ATAGACATGAATAACC rs6095323 AGAGCAGCTGGACAAC[C/T]CAAATCAACGCTGGAC rs6095325 ATGTGAAACTGAAGCA[G/T]AGGAAAATACTTACAT rs6104651 CATAGTAAGTACTCCA[C/T]GAATGCTAGCTTTTAT rs6117825 AATTTTCCTAACTGAT[A/G]AGACTCTCCTTGAAGT rs6117825 AATTTTCCTAACTGAT[A/G]AGACTCTCCTTGAAGT rs6127813 AAACATAGCTTGATTC[A/G]ACAAATACCTACCGAG rs6134772 TTATTGTTAATGTTGqA/GJGAATACTTTAAATATC rs6134777 ATGAAGAGCTAGAACT[A/G]AAAGACCACATAGGGG rs615847 AAGAATGATTGTCTCC[C/T]CAGAATCCACACGAGC rs619037 ATGTTGCAGTAGGAAT[A/G]ACCTTGAATCTTATGT rs627629 GTCTATTAGATGAACA[A/G]CTACAAGTCTCTTCTA rs632248 GGCTAAGGTAACAACC[A/G]GAAGGTACTCATTCCA rs633265 ATTCACTGGCAGTAAG [A/C]CTCCAG AGCTCTTTTC rs635331 TC AATATCC AAGTAAA [A/T] CATTTTG CTG GTTTAA rs642499 TAGCAAATTTGTGCCT[C/G]AGAAATCCAATGTCCC rs6427900 TTTCTACACCTCTCTC[A/T]GAAAGGAAATGTCAAC rs643437 ATGCACCTTTGAGCTA[C/G]GGCCAGGCTCTACCAC rs6446166 GAAAATGGAGCAATAC[A/G]CACTAGCCCACCATTT rs6446605 CCCGTAAGTCACAAAC[C/T]GGCCGCATGGCCCTTG rs644740 TGGACCCTCTCTTCTC[C/T]ACCAAGCCTCTCACCT rs6447494 AGGAAAATCTGGAATA[C/T]ATGCTGAACCTAAGAA rs6449012 ACTGTATTCTACCCAA[C/T]GGACAGTAACATTTGA rs6449750 TTATACCATTCTAGAC[A/G]CTAGTCCTTTGTCAGA rs6452689 AATTGTAGCTCTCACA[A/T]TAAAGCTGGGTGAAAA rs6469617 AGTTAGGATTGTCTTA[A/G]CATTTAAACTGGCAGT rs6469617 AGTTAGGATTGTCTTA[A/G]CATTTAAACTGGCAGT rs6469898 CCATTCATTCCAAGTC[A/C]AAGAGTTCTATCTCTG rs6469899 AGAAGCCCGACAAAAC[C/T]GACCTTTAGAAAGATG rs6470173 AACTGAGACTGCCAAA[C/G]AGATAATCTAGAATCC rs6475790 CAAGGCCTGAATCAAA[G/T]CTCAGAGACTTGAAGC rs6477360 TGAGATGAGTGTCTAC[A/G]ACTTACGCTTGTTCGA rs6477554 GACTGTATGGGTGGAC[C/T]AACATAAATTGACCCA rs6478237 ACAAAGCCTCCTTTTG[A/C]ATGGATTAGG AAAACA rs6484552 GTATAGATAATCTTCC[A/C]AGGATTGTTTAGTGAA rs6485030 AAGACTGCAAAGCAAC[C/T]AGCTAAAAACACCAAG rs6491786 ATGTGTTATGTCTTTC[A/G]AACATCTGTCAGTCAG rs649721 AG AGG AG AATTAGTG A[A/C]AAATCCTCTCACAGTA rs6497456 AGAGACATGAAGCCAG[A/G]CAGTTAAGGGAATCTG rs6497674 TAGCTGTCCTCAGGAT[A/T]AAACTTCCCACAAGAT rs6502324 TCCTTGATGGTATGAAlA/GlGAAATTGCTCATAACA rs6502325 ACTGTATAGAGATCAAIA/GJACCAGAGTTCCTTCTT rs6505045 CTTACATTATGTGTAG [C/T] ACATTAAGGGCTCTTT rs6505710 ATTTTATTCCTGCTAC[A/G]ATCTTTATTATTTATG rs6505717 AGTACAGACAGTTCAAIC/TJTTCAAGGACATCATAC rs6506966 TGGACAAAGGCTTTGC[A/G]CTTCGGGGTGGAACAG

rs6508322 GGCTGπAGTACCCAA[G/T]GGCAACAACATGAATG rs6531216 CCAAATGAACAAAAAAIA/GJCCATATCCAGGTTGCC rs6533426 ACTGAGAGATAGTATA[A/G]CAGGTGAAAAGTGGGA rs6545316 TTGGTTTCTAACTAAC[A/G]CAACGTCTAAGAAGCA rs6546173 GCAAGCCTTAGACTAG[A/G]ATAACTTCTTAAACTT rs6554923 AAGAAAAACAGAGGAC[A/G]GGAATTACACAGGTCC rs6555784 AGGTGCCACAAGTCAG [A/T] ACAGTTTTCTnTCCC rs6577934 TTCTCATTATCCTCCC[A/G]AAAAACGAAGCCCCAT rs6582553 GCTCTAAAGAAACAGC[A/G]CTTGCCTGGGCTTGGC rs6588759 AAGGTCAGCACTGTCA[C/T]GTAAGGTATGTGCTGA rs6590248 GGTGTGTTTTATTCAC[A/C]ACAATCCTCAGAAGTG rs6590290 AAG AACATG AACTG AG [A/G] CCTTG ACTC ATTAACT rs6592344 GAGACCATAAAGTCTA[C/T]AGGTTGGAGTGTTGTT rs6602164 CTCTTACCTGGGTTAC[A/C]ACACCATCTGCAATGT rs661609 CGTCACATTGTCCAAA[A/T]TGGCTCATCACCTCCG rs661889 TTCAGCAAATAAAACT[A/G]AGAAGTGCAGCCAGTG rs663978 TGAATGGTCTGCTAGG[A/G]AAGCTTGCATTTACTT rs6667872 TCTCAGTATCAGAATA[C/G]AAGCCAAGTCTGGCCT rs6676401 TTCTCTG CCTATGTCC [C/T]AATTTAAAACCTACAC rs6677798 AAGTCTTGGACATTTA[C/T]CCAATAGCTTTGGAAG rs6677802 GTATCATCTGGTCACA[C/T]TGGTCTGCTAGTAGTT rs6697738 GAGTAGAATGACTACAIC/GJCTAACATCAATGAATC rs6699979 TTAAACTGGCTTTGCA[C/G]AGCTACTAAAGGAGTG rs6705605 GG AATTCTTGG ACCTG [A/C] AAGG AAGCA I I I I I I I rs6718946 CCTCCCTTAACTGCCA[C/T]GTTGACCCTGGGCACT rs6720902 GACCACGGGCTTTGAG[G/T]AAACATTGGCAGTAGC rs6731529 CCCTTCATTGCTTATC[A/G]AAACCTTTTAGGTAAT rs6732355 TCCTCTAGAACAGAAA[G/T]AACTTAGAACCTCTTT rs673240 ACATTTCAAGTTCCCA[C/T]ATTGACGTGGCTGGTC rs6733843 GGGGCCACAGTTGGCA[A/G]ACAAATCACATCCTTG rs6737177 CTGTTTTAAAAG ACTG [C/T] ATTTC AGTATG CATCC rs6751402 ATTTGGACACACCGAT[C/T]AACACATAGATACATG rs6751526 TGTTAATCTACATCTA[A/C]GAAGCTCAGTGAAGTG rs6763712 TTCATTTTCACTGACC[C/T]AAGGAGGAATAAGACA rs6766592 GAGCTGTAAATATGTAIC/TJAATGTGAAGCTGATAG rs6767992 AGAGAACACAATTAGA[A/G]GAGGGTAATTCAAGAC rs6774873 CATCCTTGGGACTAGA[C/T]GGCATTTACAACATGA rs6783622 ACCCTTTTAGGTTTTA[C/T]GGCTTGCTGTGAGGTC rs6791790 CAAGAGTGATATTGCT[A/G]AAAGAACACGAAGTCA rs6801310 CTTCCCCCACTCCTAG[C/T]CACCACAACTTAGCCA rs6814800 TAAGGACACAGATTCA[C/T]GGGTGAGCTTTAGGGG rs6816017 AAGGTCAGCCTAGCAG[G/T]AGTACAATAAGCAAGG rs6818865 CAAACTAATTGAGCGA[A/G]GACTCATGTATCACTA rs6825008 AGTAAGL I I I I I AGAT[C/G]AATTTATTATGGATGA rs6829190 TTGTCATTGCTTTGTA[C/T]GTGTGAATAAACTTTA rs6836327 AGATGAAGTAATAATAlG/ηATCAGGGTAGTCCTAA rs6840609 CCCAGACCTCCTGACC[C/G]GATGCAATTCTCTCCC

rs6849903 GGGAGACAGCAGAACC[GZT]GAGAAAGAAATGGGTG rs6852285 TTAAGTTTCATCATAG [A/G] AGG AGATTTGCAACTT rs6852493 TTTAATATCAAATGTG [A/T] AATAGGAAATGTATTA rs6860898 CTGCTCTGTAAATACG [A/C] AAATACCATTCAACCA rs687328 ATGTTGCTAGATGTGA[CZT]GGAAGATACAAAGAAG rs6880404 TTTTAGGGTTGATTTC[A/G]CCTAACAGATTATCCA rs6883415 CTACACAGAGATTAGA[C/T]GCCAGCCTCAGCTACT rs688933 AGGCTTATAGTATGCA[A/G]CCTTATATCCATCAGC rs6893843 TGGAGGAAGTATTGCC[AZG]GAAGGATTGAGTCAGA rs6902835 AAGAAGAAAACTAAAA[C/G]TCATTACAACATTGGA rs6905476 GTAACAGCAACTACAT[C/G]ATGACGCAGATACTTG rs6906788 TTTGCAATGGTGTTCT[CZT]AAAAATTAGAATGTTA rs6909578 CTCTCACCTTATAAAG [A/G] AGCG ACAG AAAG AATG rs6916232 CTTTGGGACTTTCATAIA/TICCAAAACAGAGAATTT rs6917097 ATTTTATCCTTAATTA[C/T]GCAAGCACCCAGTAAC rs6923212 TATGTAAACTGTTCCA[A/G]AAGGAATATGTTTACT rs6924957 ACAGTTTATGCATCCA[GZT]CGTTAAGTCATAGCCT rs6924957 ACAGTTTATGCATCCA[G/T]CGTTAAGTCATAGCCT rs6925312 ACACATTTACAGTGAA[A/G]GCAAG I I I I I C I I CTG rs693253 TGTCTCTTCCGGTAGA[C/T]AGCAGTAAAGCCTGAT rs6953625 ATTGGG AAGTTTGTTG[C/G] AAATGG AAATGG AAAG rs6955265 ACAGGATCTAGTGCTC[A/G]ATTGCAAGCAGGTGAC rs6955954 GGGAAAGAAGCACACA[GZT]TGAGTGAGAGACAGAG rs6956284 ACTCTATTCCATTGGA[A/G]ACAAACCTAGGTTGTA rs6956675 TTTTAAAATGAGAACC[A/G]CAATCAGAGTTAAATG rs6975680 GAGGAATTCAAAGACC[AZG]GGAATAAACTCATTGA rs6975798 GTCTGATGTTATTGAA[AZG]TAGGATGTTCACTTGA rs6980687 TCCATAAACCACATGA[AZG]GGCAGCAATCTCATGC rs6981660 TTTCTAATAAATACAC[A/G]ATTCTATGTCAAATTC rs6982260 CTCCAAAAAATATTAC[A/G]CCAATGCATGACCTTC rs6996243 GTTCCTCACAAAACTA[C/T]CTTTGCTCTATTGAAG rs6998702 ATCAATACTTACCCTA[A/C]AGCTGCAGTAATTCAG rs7004124 TATAAGGATAGAAAGAtC/GlAGGATGTAAACTCAGA rs7005284 GATGTGGATATGTAGC[AZT]AGCTCTTGTGCGAACC rs700547 ATGGCCTATTGATGTA[CZT]GACAGCCATTTGCTAG rs7006704 ATTTGAGTCAGGAGAC[AZC]AGAGCTGTCAGGTACT rs7007223 TCAGTAGTTACTATAT[AZT]AAAAAGCAAGTGTGAA rs7011618 ATCAATCAGTAGAAAA[AZG]TCATTCTTGGCCTATT rs7013158 GATGAAAGAGTGTGAA[CZT]TAAATTATTGAAGTTG rs7013903 CTGCTACTTCTAGTGA[AZG]GCTCCTCATTGGCATA rs7014818 AAAATTTAG AAACCTG [AZC]ATATACGCAAGTGTTG rs7017087 TGATGACATTATAAAA[AZG]GAAGAGAGACAGGAGC rs7017143 TCAGGTACTTGATACA[GZT]TGGCTACTTTTATTTT rs7019068 GGCAG ACATTTAATTG [CZG]ACAGCTTTGGTCAGAT rs7021834 AATATTTGTAGTAAAG [AZG]CCCATCTGTTAAAGAA rs7024250 TGCTTTGGGTCCGAGA[AZC]GTAGTGTTATTTCCAA rs7027322 AATTCAGTTGTGTGAA[CZT]AGAACACAGTTTGTGT

rs706551 CACCAACATTCTGAAC[A/C]GTACCATTTAGATGTT rs7067701 CCCCAAAGACAACCTA[C/G]ATGAGTGAAGAGCCAA rs7067738 ACCTGCCTGGTGTCTA[C/T]GATCTGAGACTCTTCT rs7076566 GTTGATTTACCAGTAA[A/T]TGCCAGGTACATACAC rs7076691 CACAGAGCCAGTAACA[A/T]ATAACATCTCTCTGAC rs708475 ATATTGCCCAGGCTTA[A/T]GTAAAACAAAATACTG rs7089460 AGGAATAGCGAAGCTA[A/C]CTGAGAATCACTTGTT rs7090837 CCAGCCCATCTCTTCA[C/T]AGTTTTAGGCCCAAGT rs7091247 TGAGTTCCAGTπTAA[C/T]CAGCATTTGGACATAT rs7107881 ATATGGAAGAAACCAG [A/G]AATAGTGAAATTTGGG rs7116628 CTTTGATTGTATGGCA[A/T]CCTCTTATTCTATTGT rs7117687 CAACTTGTGTTTTAAC[A/T]AAATCTCCACAGGATT rs7117839 ATGAAGTCTTGACCAA[A/T]GGTACACACTCAGGCA rs7126236 TTACTCCTATTTAGCA[C/G]CTCCCTAAGAAATGAA rs7130480 ATGAAAGTAACACCTA[C/T]ATCATGGCATTACTGG rs7135085 CTTCACGCCTTGCACA[C/T]TGGAAAACTGTCATGA rs7136397 TAGGGAAGAAAGCCTAIC/TJGGTGGTTATGGAGGGA rs713978 TGTGAGAATAAGCATG[A/C]AGAGTCTTGCTTTTAA rs7148456 CACTGGGAGTCCACAA[C/T]GGCCTAATGCACGTTT rs714875 CAGATCCAAGTGTGTT[G/T]AAAAATAGTGTCCCAG rs7152210 CTGTTCGCACTTCTAC[A/G]GAACAATGTGCAATGT rs7163643 ATAGCTCAAAGAGGAA[A/G]CTTAGAATCAAATAGC rs7165874 CTACATGTGTAGTTTA[A/T]ATCTGATGCATTACAA rs7168308 AATTAATGGAAGCAGT[C/T]ACATGAGCAAGTTTGC rs7169478 GTGAGCATTCAGACTC[A/G]ATAGTGCTGTTCTGTA rs7175099 CCACCAAGGTAACTGC[A/G]ATACATTCATTAAAGG rs7179293 TTCTACTCTG AAATTG [A/C] AGTATATTGTCCTTCT rs7185053 ATACAGTACACATTAC[A/C]ATTTGCGTCTAATGCC rs7190907 GTTAATATCAGGTGAAμ/GlATTTTTAGGACGTGCA rs7191101 GTTAATGAAAAGGAGAIC/GJAAAAACCAAGACACGG rs7191770 TTGTTTGGTTAGGTGGfA/TjATAGGCAATATTCTGA rs7192512 CACCCAAACCTACTGAIC/GJAATAAATTGGGGGAGA rs7195806 AAATGGCCCAGGCTGC[A/C]AAAAAGGGGAGCAGCA rs7199114 AGCCAATTCAAAGAGA[A/T]TCCCTCACATGGCTGT rs720727 CATCTATAAGTGTCGG [C/T] CACAAG C ATCTACTAC rs7215839 TTAACTGTAACTAGTAIG/TIATGCCTTTCAAGTAGA rs7220146 AAATAGTAGTCAAATC[A/G]AATTTCCAAGCATCCA rs7228559 ATAGCCACATTTAAAC[A/G]GAATCATTAACTTTGG rs7236575 CAATACTGAGGAAATA[C/T]GGTTAGTTTTCAAAAG rs7236715 CTCCTACCACTCTAAC[C/T]ATACTGCGGTCTCTGT rs7238329 GTTTATTTTTGTCTCTlC/GlAATACTTTAAGACTTT rs7240443 CCTCAGTGACGCTCTA[A/C]CATAGCTTGTTATAGT rs7241635 CTCCTTTGTTTCTCTC[A/G] CATCCTAC ATCCC ACG rs7253956 CCTAGAGGACCTGGGAIC/TJCAAGCTGCTAGACCAC rs7268711 TCACACACTTCCGTAA[C/T]GTTTGAAATATCAATA rs7272436 GGAAGAGAAACAGACTfC/GjAGTAGCCCAGGCCAGT rs728047 ATGACAGAGCTTCAAA[A/G]ACCAAAGATGAAACGA

rs7281608 GAGGTTTATACCTTGAIC/TIGTAGAGTGTGGAATAA rs729438 TCCCCCAGGAAGTGAC[A/G]ATCATTTGAATCCTGG rs7294776 ATATTGAATGTAGAAC[CZT]GTCTCTAAGCACAATT rs729784 GAGTGTCTAGAGTGAA[GZT]GAGGTAATAGTCCTAT rs7301998 GAGTTCCCAACCATGA[CZT]GGGATGTGGGTAGAAC rs7302315 AGCTCTGCAGACCTGA[CZT]AGATGTGGCAAATACA rs7302914 CCATGCCAACCGGTGC[GZT]CTGCCAACACCACTGC rs730354 TGCATCATGAACCCAA[CZT]GGACTL I I I I I I I I CT rs7304649 TACAGTTAGGTAAAGA[CZT]AGAGTGGTGAGGGTAA rs730561 ACTGCAAATACATTTA[AZC]AGGAAGGAAGAATATT rs7311488 GAAGTATGAAATGAAG[CZG]CACAATTGTTTATTAG rs7312492 GAAGTAATAATTCTCA[CZT]GTAGGTGGAGAGCTGC rs7313816 CATACACAGGACTTCC[AZG]AGTTTTCTCCAGTTCT rs7317235 CTGAAGTCCTTGCTGC[CZT]AGTTCAAACTTGTTCA rs7327778 AAAAGATACAAACATA[CZT]GTAAGCTATAAGAAAT rs7331598 ACCATATGCTAGGTAA[CZT]TGGCTAGGCATGGGAG rs733508 GGGTGCCTAGGCTTTC[AZG]CATCAAGTGGGACTTG rs7338402 AAATCCTACCTCCACT[CZG]ACAACTGGGCTTGCAA rs735392 AAGTGGAACACCCACA[CZT]TAAAGTATTAGAAAGT rs736239 CCAATTTTAATCCAAC[CZG]AGAATCAAATCCTGCA rs7373237 TAAGAATGTATTGGAA[CZT]GTACTGAGTTAAGAAT rs7414246 GAAGCTGACAGACACA[CZG]ATAATTTTCAAGCCAG rs7421353 TCTGTGCTCTCAATAA[CZT]CCTATATTCTTGTGCG rs744564 GAAGGCGGCCTGAACC[GZT]AATGGCCAAAGAGGCC rs745471 AGAGAGGAGTAAGAGA[AZG]TAAGAAGGACATCACA rs7487640 GAGGCTACCATGTTAG[AZG]AAAGGCCAAATGGAAG rs7493192 TGACTTAGGAGTCAAA[AZG]AGCATGGATCCTACTG rs750123 ATAATTTAGTGCTTTC[AZG]ATAACTGATATGGGAA rs7501838 CTGTCAAATCAACTCA[CZT]CTTCAACAAAGGAGTC rs7505697 CCCCTCACAACTCCAC[AZG]AAGAACGTAGTCCAGG rs750576 AGAAAAGAAAGCTCTC[CZT]ACACTCTATTTTCAGA rs751271 TCGTGGAACTCAGTAA[AZC]CCCAGAAAGCTGTGAC rs7516762 GGATGGAGTTCCAGGC[AZG]CTCTTCAGGTAGTAGC rs7517569 GCAGAGCACTGAGGGA[AZG]TAGAGACAGGAGAAAC rs7517978 ATATAAAAGAGCTTGA[AZT]TCAAATGTTACTTTTA rs7528675 GAATAAACAAAAAACA[CZT]TGCATACAGGGTAACA rs7537656 CATCA I I I I I I I I CAA[AZG]CATCCAGCTTTATATT rs7547363 CAAAATGTTGCTTTTA[AZG]GTCGAGATCAGGTAAA rs7552434 TTAATAAACTGGACAA[CZT]GCTCATTCCTGAAGTC rs7559372 CAAAATGAAATAGAAA[AZC]AACAGAGTAGCCCAAA rs7563316 AGAGGCAAGGGCAACA[CZT]TGAAACAGACCAATGC rs7565023 TGAATATTTCTACACA[AZG]TAAATGCATAAGTACA rs7567280 AGCAGACCAAGTGGAA[AZC]TGATTAACCAATCTTA rs7570682 TCAAACTTCATGTCAA[CZT]TTCCAGAGAGTTACTT rs7577717 GTGGAAATATTTGAAA[AZG]CATTATCCAAGTACAT rs7590007 TTTTCTGACACATCAA[AZC]ATTTCTCAAGTTCATC rs7594119 TCAGAACTCTGTCTCA[AZC]GAGGCGTATTTTTGTT

rs7598248 TGTGTGGCCTGAATCG[A/T]ACAGTTTAGATGAGTG rs7613492 AATCCATTGAGCTGCA[A/G]ACACTCCAACTACACT rs7616299 ATGGCGCATATTGAAAlC/ηGAAAAGGATATAGAAA rs7624432 GAGCTGGAAATAAAGA[AZG]CAATCATTTGAATCAA rs7628402 CTTATGAAGTTCAAAA[A/G]TGAGTAAAACTAACAC rs7628779 CCATGCCCGACAATCA[G/T]ACACTTTTACATCACC rs7636153 GTGTTGTAAGTACTGCIC/TIGAATTATTAATTTCCA rs7654444 CTATTTTCAGCACATA[AZG]GAAGTATCCTGTCTTT rs7655585 CTTTGTTGTATTCTCA[CZT]ATTTTCCTGTGCCATT rs7656673 TTGGTTCTCTCTATGC[AZG]CATCCTGGAAGTGGAA rs7660550 CACGGCCCCCCGATGC[AZG]AACATTGCCAGGCCCT rs7662513 CAAATACAAGTCTACA[CZG]AAAACTGAATAAAATT rs766857 TTCCTTCTTCACTTCA[CZT]TATGCTGAGCCTAAGC rs7673867 ACCTCCTTTGGCACAC[AZC]GTGGTGACTGGGCAGA rs7677760 TTCTCACCAGTATAAA[AZG]GCATTCA I I I I I CTCC rs7679792 TCCTATAACCCAGGGA[CZT]TCCACTGTTGGATATA rs7692314 GAGCGAGGAAGGCAGA[CZT]GAGAGGATCTTTCCAG rs7693199 ACATTTTGTGGGTGCA[CZT]AACGAATAAATGAAAA rs7699961 GGCACTCATAAGCCTA[AZC]ATGAAAAATTATGTCT rs7701321 GAATGAATGAGGTAAT[AZC]AACCAATCCACCAGTC rs7708421 TTTTAACATGAAGTAA[AZT]TCCCTAAGGAGCCTTT rs7714857 CTGAAAGATAACAAAA[GZT]GCGTGCTCATGGGAAA rs7733733 CCAATAGGATATACGC[AZG]AAGGTTAATATTAGAA rs7738340 TTTTCTCAACACTCTA[AZG]CAAAGTGGGCGACGTA rs7745577 AGATCCATTTATGGAA[AZC]TGTCCAAGACACTTAG rs7748736 TGGTCTGAAATTGAGA[CZT]GCTTATTGAATGCTTA rs7750426 GATTTCCCTTGTTGAA[AZC] CTTATACACACTTACC rs7752425 GTGCACGTCCTCTTTG [AZT]AACTCTCCTCAGTAGG rs7756362 GGACATTTGTGTGAGA[CZT]GACCAGTCAGGTCCGT rs7765427 CAGGATATTGGACACA[AZT]CTGAAGAGTAAATTCA rs7777679 CAGGCCTGCTGGGAAC[AZG]AGAACAGAGAGAGGAC rs7778110 TAAGCTGTGATGAAGA[CZT]GTCCCTGCTACGCTAT rs7779004 TAAAACAATTCAATAG [AZT]ACAGCAAACATTAAAA rs778354 TTGAGATCCTACAGCC[CZT]GAGGAGATTAAGCTGC rs7795090 TGTTGTAATGTTAGAA[AZG]AGTAGAACAGCTTGTG rs7795796 CTGAATCATAGATCAC[AZG]GGAAGAATATTGCACT rs7798679 TTTCTAGGCAAACACA[CZT]TGAGGACTCTGGCATC rs7822883 CCAGCTTTGCCACTTA[CZT]GGTTTCACATGATAAG rs782593 GACTGGACTTATCCTC[AZG]GAGACCGAGACTCTCT rs7826102 CAACCTCAGTGGAAAT[CZG]ACCATTACTGAGGCCT rs7830390 ACCACACTGAAACTAA[GZT]GTATTCCAGTTCTAAA rs783073 TCCAG AAACAACTCTG [AZCJATCACAAGAAGTTAAG rs783250 GAAAAAAATACTGAAG[AZG]AGAGTAGTTCAGGGTG rs7834089 ATCTCTTGCTCTGGTG [AZG]ATCTGGCTGAATAGTT rs7835152 CAGAAACCAGGGTTCC[CZT]CATTTCCAGGCTTTTG rs783841 CAGAAAGGAGAAGAAC[AZT]GAATAGGAAGAAGATA rs7838821 TACTCTCAAAATGACC[GZT]GGGTGGTGAATCGAAC

rs7843358 TTATTAAACATGATAC[A/C]CAAAGTACAGTGAAAA rs7844027 ACCAAAAACTGTCTTA[C/T]GTCAAACTCCCACACC rs7863451 AGATGTCAGTTTTCCC[A/G]CATGACTGATGTCACT rs788216 CCAGAAGTπTTTGGT[A/T]AACTCATTTGGCAGCA rs789030 CTCAAGTCTCCAAATA[C/T]GCTGCCAGAAATTTTA rs7896663 CTCTCTTCTCCCTATC[A/G]ACCTTCTTCTCAGCCA rs7900746 GTAACATCTTGTAAAA[C/G]TATAGTGTACGATATC rs7901463 CAAAAGTGAGATCATA[A/G]ATGGAGAAACACTTAG rs7901744 TπTATCACTCTAAAA[C/G]ACAGTTAATAAGTTTA rs7911998 TGTCTACAGTTCAGTG[A/G]ACAGGCAGTGATGGGC rs7913419 ACCAATGTTGGGCAGC[A/G]AAACTGTAAAAGTAGT rs7921545 GG ATAAG GTATG ACAT[A/C] AGTAG AACGTGTCATC rs7927704 GACAAATCTTTCACCA[A/G]GCTAAACTAAGTAAAA rs793557 AAAGTCTGTGATCTGA[C/T]GTAAAAGACTTGGCAA rs7940927 ATCTATATTCTCTTCA[C/T]AGTGATTCCTTGAGGG rs7945575 CAATCCAGAAGGTATA[G/T]GTACAATCAAATAATG rs7956826 CATCTATGATTAACTA[A/G]GAAACACTTTCCAAGA rs7960483 TTTTATTCCCTGTCCA[G/T]TAGAAACGATTTACTT rs7966105 TACAAATAGGACATCAIC/TJGAAAACTGCATCAAAT rs796694 GTTCGTCCACAGCTAA[A/C]CTTGCTCTATTATACC rs7972470 AGGGTAACTTGTATAGtA/GlAGAAGTGTCTTTCATT rs7975586 GACAATACATTAGGTA[C/T]ATTTTCACACCTTACT rs7977461 TCACTCTCACATTTCA[A/C]TAAGTCTTGTAGAAGT rs7979816 ATTTCTCTGTGGTTCA[C/T]GGCAAGACTGCATGGT rs7980576 TAGGCAGGGATAGAGA[C/T]GGTTTTCCTACTTAAT rs798442 GAGCAATAATCCAATG [G/T] AAACTCTAATATAACA rs8008963 TCTTGGCATGCTGAAC[C/T]GAAAAAAGGGGCTCAG rs8015136 AGCCTCTAGAAAGAAC[A/G]CAGGCCAGCCAACACC rs8021814 AAGAGGGTGTGCATTG[A/G]AAGGCTACCTATTAGG rs8023274 TTAGAGGCTACTTGGC[C/T]AATGAAGTCCTGACCT rs8033957 GAAAAGCAATCAGTGG[C/T]CATGTAAGCTTTGCCT rs8041258 GGCCACTCCTCTGAAT[A/G]AGCCCAGATAAACACT rs8043148 ATAAATTCTTGGCAAT[C/G] AAAGTCGTCCATTG AA rs8050099 GCCTGAGGTGTCAGAA[A/C]CAGATCAGAGGAAGTC rs8061285 CAATCAAATACCCAAA[G/T]AGCTAGGAGAGAAATG rs8072988 GGAAAAAAGATTTTCC[A/G]GCTCTTGACTTATAGA rs8074960 CCAAAATGGAGATAGA[A/G]GAGTACCTACTGGCTG rs8078319 TGAATGAAGGAGATGG[A/G]ACTCAGGCCTGCTGTG rs8078844 CCATCCCAACCAGAGA[A/C]CCCGTCATTCCTTCCT rs8094588 AGCACTGACTTCAATA[C/T]GTCCATCAATTTTCCA rs8097577 CATCTCTGTACCTATC[A/G]CTCTTTAATGGAAAGC rs8097774 CACCCAGTTAGAATCA[C/T]CCAAAGGCATTTCACT rs8100438 GCTGGTTTGGTGAGAG[A/G]CAAAATTAAAAGAACC rs8112882 AAAATATCTCCAGCAC[C/G]AATCTTAGCTTTTGCA rs8113891 ACACTTTCAAAATAAA[C/T]GAGTGAATGAATAAAT rs8119959 ATCAAATGAGTAAAATlA/GJAAACTACTGAGACAAT rs8120943 ATTAATTTATCCAAAA[A/G]TGCCAGTCTCTCTTCC

rs8122510 CCACTCCATGGCAGTG [A/CJATCATAGGTCCAGAGA rs8176345 CCACTCCCGCCAATAG[C/T]AACTCTGTCACATTTC rs8187945 TTTTTAAGTAGGTAAA[A/G]TGCTCCCCCAATGTTA rs818944 AGAGGGATTAGGCACAIA/GJAATATTGAAGGTGCAG rs820296 CTTTGCAATGTG ACTG [C/T] AATTCCTCCCATCAAG rs824633 AACTCTTTGTAGCAGT[A/G]ACAGCAACTGATCCCA rs826686 GTTATTTACATAGTTA[C/T]AATGCTCTTTCAAACA rs826692 ATTTCAGGAAATTTTG[C/T]AATTGAGGCACAAGGA rs831179 TGGATACTGGCTACCA[A/G]GG I I I I I ATCACTTTC rs839878 CAAAAGTAGACTAGTAtG/TJGCTGAAATGCAATAGT rs839879 TTGAGTTTGATAAGGC[C/T]GCAGAGATAGACATGA rs844116 CTGGAAAGAGATAGGTIA/GlACATCTTTGTATGGGT rs853753 ATACACATAAAATTTA[C/T]AGCCATTGCAAAGCCA rs8587 TTTCCACACAGGCTAC[A/C]AGATATTTTATTTACA rs858942 AACTGGAAGATGCAGC[C/G]CGACCTTTGTTAATGT rs865094 CCCAATGTCTCATGGC[C/T]AGCAAGTATGAAACTC rs870033 G AAGG AGCTTGGTGGG[A/C] AAATAGG AAGG ATTCT rs870254 AATTTCCATTGTAAAA[A/G]CCCCTCATGCCCTTTC rs870695 CATACCATCACCAACAIC/GJCGTAAATATGATGCGC rs875772 AGGAAATGATTCTCAC[A/G]GGGTTGGGGCTGTCCT rs880026 CACTTATCTAGGGAAA[A/G]CACATTGTGAGCCATT rs882612 GCTTGCAAACAGCTTG[C/T]AGCGTATATACCATTT rs885076 GAGTTATAGTTCAATA[A/G]ACACCATGGCTGAGCA rs885161 TTCCTCTGAGTTTCTG[G/T]AAAATACACACATCTG rs885162 TTCAAACATTCAAAAA[A/G]AAGCAATGCAAATAAA rs889268 TAGAACAGGGGAGTTA[C/T]GGTCTGCTCCAAGAGG rs895193 ACGTGATATACGTGACIA/GJAAAACAAATGAGTGAA rs900668 TGCTGTCTTGACTTGA[C/G]TAACAGCTACTAGATA rs902581 CAAGTTTATATATCAAIA/GJGTAACCATCACATCCA rs908916 AGGGCCTGGATATTGC[A/G]GAGAATGAGATGCTGG rs910534 ACCTTAGGGTGAGGAC[A/G]AACCTAAGTCTGCAGA rs914993 AAGGGCAACTGGAAGAfG/TJGAAGAAGAAGGAGAAG rs918107 CCAACTCTGCAAAACA[C/T]TATCATTCATAACTGG rs9295173 AGGCTTGAGATTACAA[C/G]GTGAAAACTGTTTCTT rs9296495 TTCTGTCTAGATTCCA[A/G]TATGAGGCTATTGCTG rs9298281 TTCTG AATATG GTTAG [A/C] C AA I I I I I CCAGCATC rs9299046 C ATGTG AATGTG GTTG [C/G] AAAACAAATGTATTAT rs930223 ATG CTAACTTAAATTA [C/G] G CAGTC AC AAAAATAC rs9306459 AGTTAGCTGACCATCA[A/G]AAATCATCCTGGCAGG rs9307847 ATCCAGAAGGCATTCC[A/G]AACTCTGACCTTAAAT rs9310350 CTCAAATGCAATGTCA[A/G]TCTTGCACAAAACATT rs9316670 TGTACTAAAAATATCCIA/GJAAAGTATTCAGGTATG rs9328513 TTAAGAGCCATGAATA[A/G]GTATCTCATTACCTTT rs9329165 TTACCACTGGGACACT[C/T]AATTACATTCAGCTAC rs9329166 CTCCTGTG I I I L I I IA[C/T]CACTGGGACACTTAAT rs9331931 GCACCCAAAGATAAATIC/GJAATGATGTTACGAAGC rs933654 TAGGACTAAATGAAGA[C/G]GTGAGGGCAGTGTCCA

rs9346035 AAACTAAAGCCATTAA[A/G]GTGCGTATAAAATTGA rs9354810 GGTAAATGCTGCTTCA[A/T]TCTCTATATCTGTATA rs9360790 AAACAATATTTTCAAA[C/T]GTCCTCAATAAAATAG rs9363771 TTATCTACTGATTTAC[A/C]CAATTTACAGAGCCAC rs9373118 GTGCTGGGAAAATGGA[C/T]GGTGCTGGATAGCTAC rs9376083 AAAACTTATTCTGGCC[A/G]AAATAAACTGAAAAGT rs9385740 GTGTAACTGAGCTCCC[C/T]GCTAGCCTGCAGGCTT rs9389245 CTAATGATCTGATTAC[C/T]ACATTCAGGATGCATT rs9400016 GCTCTTTGGCTGTCAG [G/T] ATCTCAAATTCAACAT rs9402666 TTTATTGGAGAGACTA[C/T]GTTTTCACCAATGCAT rs943262 AATTAGGACACTAAGA[C/G]AGAGCTGGAAGAACTT rs9443027 ATCTAGTCCCAGAAAA[G/T]GTTTCCAGGAAGATTT rs945033 TGCTGGTTGCCACTAC[C/T]AGGAGAGGGAGGCTGC rs9458363 TATGCATGAAGTCTCA[G/T]TAACACAAGACATCGC rs9464431 TTGTGTGAACTTCCTA[A/G]CTAGGCATTCAGGGAA rs9466145 GATGTATTTGTCCTCA[A/C]GTAAGAAAATAGTCAA rs947377 GAAGGAGCTGTACCAC[A/G]GACAAGAAGAAGATGG rs9481070 GAGTGAGAGCAGGGAC[A/G]CTTAGTTTGCAGATCC rs948460 TGCCTGAGTTTCCCCA[A/T]GAGTAGCTCATTCTTT rs9487240 AATTAGCAAATTCTTA[C/T]GTGTGGCTTAGAGTTT rs949229 CTCTTACTCTGTGTTA[C/T]GGAGACTGCCTGGGAC rs949944 TCTGCATTTGTAACAA[A/G]CTTTCAGGTGACATTG rs9502593 ATACTTAATTTTTCCA[A/G]TATGGTCTAGGTTAGA rs9505351 GACTGCCTGACTTGTA[G/T]GTGGCAGAAACAACTG rs951574 AGCCCTGAAAATCAGC[A/G]CAACCTCGGACATCCA rs9519135 AATAGTCAAGTGAAGG[A/G]AAGTTTTCAGTGAAGA rs9519136 TTATTTGTGAGTGATCIA/GJACGTGAAGGAAGAAAA rs9536485 ATGTACTTTGGTGCAG[A/G]AAAAGACCCATGGGTG rs9542290 GTGCTGGAAATGTCCA[A/G]GACAGCATGTTATATG rs9548386 ACTCTGTACAAACACA[A/G]TC I I I I I I AATATCAA rs9568927 ATTTTAATGAGAAAAC[C/T]GTATCTATTTGACTGG rs9587525 TTAAGTTTCCAATAGC[A/G]CATAGA I I I I I I I I CT rs9592445 TGTTTTACAAATAGTA[A/C]CCTTTACAAATAGTAA rs963364 GTGTAATTTCACAAGA[A/C]AATGTGGGCCACTTAC rs9634125 CCAAACTTGCAACTCA[C/T]ATCTGAAATTGGAAGG rs9643109 GAATGAACTCAAAATA[C/G]ATTGTGGACTTATATG rs9649972 TCATCCTATTAGAAAA[C/T]GGCAGAGCAGACGCTC rs9666878 TTGATTTTTGGATGCC[A/C]ATCATGTGCTGAATAC rs9666878 TTGATTTTTGGATGCC[A/C]ATCATGTGCTGAATAC rs974542 CCATAGTAGTACTCCAIC/TJCAGCACATGAGAATAA rs9770283 AATCAGAAATACrTAA[C/T]GTTGCACTTTCGGTCA rs9785216 ACTTTACCCTTGTCAA[A/G]TATACCTCCATAGAAA rs980373 GTGATGGCCCAGAAAA[G/T]AGTAGTGAAGCCAATT rs9806846 AGATCAGTGAGGGAGTIA/GJAACTTAGCTGCATTAA rs9807505 CAATCCATTTATGTAC[C/G]AGGCACGGTTAAAACA rs982655 GATTGCAAAGGGTGGAlC/TlGAAGATAGGAGAGAGG rs983249 TTGACCTGGTGAAGGA[A/C]TCCCTGGTGGTGTTTA

rs9843110 AGCACAACTTTGATCA[C/T]ATCATTCATTCTCATT rs9850420 TATGTAATCTTACAAC[A/G]CGAGTAGTTCTCTGAA rs9851591 CCAGGGCTAGCTCTGG[A/G]CATTTCAAGAGATGTA rs9854717 TTCATTAGCAAAGAAA[A/G]TGCTTCACCAGAAATC rs9871763 TAATTTG AG AG ACAAT[A/C]AAACACACAAAAAATG rs987280 TGAAGGCTTTGTCATA[C/T]GCTTTGGGTCTATCTA rs9876535 TAGTATGTAGTAGTTA[G/T]GAGAGTGTATTGTAAT rs988213 TCCTGAACAACTCTAC[A/G]ATGCCTGGAGTGCCTC rs988292 TGTACATACAACTCAT[A/G]AAATCTACATACATTA rs9906088 AGTGTCCCTGTCAACA[A/G]AGGCTGGGTTTAGCCA rs9910530 TGACCGTATTGGCTAAIC/GIAGAAGGTTAAATTTGC rs993422 TGAAAATGGAGTAATAIC/TJAGTAGGACCCAAGAAA rs9939736 AG ATTC AACTCTAAG A [C/T] GTTTTATG CAGTGATG rs9939910 CGGGAGGTCTTTGAAA[C/T]TTAATGTCTCCCTGCA rs9944695 GGTAGGCAGTTTTGCA[A/G]GCAGAAATAGACCAGT rs994556 CATCTCATTCAAGTTA[C/G]GAATCATTAGCCCTGT rs9948698 TGACTTAACTCTTGAC[C/T]CTTGGCTCTCTTTACC rs9951521 GATTTCAGTTCAGGAA[A/G]CGACTTTCTATTGGCC rs995401 ATGTAAGTGAGAACAC[A/G]CAAAGTTTACTCAACA rs9956997 TTGCGCAGTATGTCCC[A/G]AAAAGGCTAGCTAATG rs9958524 ATTGAATGGAATGTTA[A/G]GCCTCCTTTAGCTTTT rs9965071 GTTAGTTAATAACAAA[A/G]CTGTGGTCATTTCTCC rs9965472 TCTACCTCTCGTCTTC [C/T] CTAATCAG CTCCTCCT rs9966194 GCAAGTGAAAGTGAAAIC/ηAGCTGTAATGAAATTA rs9968025 TCCTAGCACCATGTGC[C/T]CTTTATGTCTGTAGCA rs996967 GGAATGCAGATTGTTAtA/qAAATGAATCTGTGTTT rs9971144 TCAGTAGTTGAGAGGA[C/G]AATGCAAACAAATACA rs9973427 TAGATGGTATTGATAC[AZC]GAGGTTAAAGAATCAG rs9977697 GCTTCTAAAAATAAAC[A/C]CTTGCTAGGCTCCCAC rs9981939 TATAACCTTCCAAAAA[A/C]TTCAACATCATCTTCC rs998564 TGGCCACATCAGATCC[C/T]CTCTTACGCCCTGGGC rs999938 CCTCTGAAGAAGTCAT[A/T]ACAAGCTGAGAGCTGA rs5018999 GTCTGTTGGTAAAGAA[AZG]TGAAAATGGATCACAG rs2862907 GTGCCAAAAATCTAGA[CZT]GATGTGCTGCTTTCTT rs41339546 TGAGCTGGCTTCCTAA[C/T]TCGCCTCCAACCTCCA rs41423448 TTGTTATTTAGCCTTA[AZT]GACATTTCATTAGAAT rs41507953 ACTACCCGGCTTATGA[A/G]AGGAGAGATCACACTT rs41446549 TCTACTTCATGACTAA[A/G]TAACTTCTGCAAGTAA rs41334345 GCTTGTCTGTATCTGA[A/C]GGTGACGGTTACCATT rs41391845 AAGAAATCTAAATGAC[CZT]GGCTCTCCCCTCACTT rs41342346 CTGTTGCATTTTAAGC[A/G]CATTCATACACATATG rs2581365 TCCTCTGTGCTCTCAA[A/C]GAGGCCACTCTGCTTG

Table 6

GENE_SYMBOL Gene Name

ANK2 ankyrin 2, neuronal

N0D2 caspase recruitment domain family, member 15

TAF4 taf4 rna polymerase ii, tata box binding protein (tbp)-associated factor, 135kda

SELP selectin p (granule membrane protein 140kda, antigen cd62)

C10orf11 chromosome 10 open reading frame 11

SPAG17 sperm associated antigen 17

CAPN13 calpain 13

GTF3C2 general transcription factor iiic, polypeptide 2, beta 110kda

N0X4 nadph oxidase 4

PARD3B amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 19

FRMD4A ferm domain containing 4a

ADAM23 adam metallopeptidase domain 23

TMTC2 transmembrane and tetratricopeptide repeat containing 2

MYPN myopalladin

HS3ST2 heparan sulfate (glucosamine) 3-o-sulfotransferase 2

KIAA0776 kiaaO776

CENPC1 centromere protein c 1

O KCTD 10 potassium channel tetramerisation domain containing 10

MYCBP2 myc binding protein 2

MRPL27 mitochondrial ribosomal protein I27

ZNF643 zinc finger protein 643

DLC 1 deleted in liver cancer 1

WDR59 wd repeat domain 59

DSCAM down syndrome cell adhesion molecule

GRIN2B glutamate receptor, ionotropic, n-methyl d-aspartate 2b

DPYSL5 dihydropyrimidinase-like 5

EMG1 emg1 nucleolar protein homolog (s. cerevisiae)

MIPOL1 mirror-image Polydactyly 1

CDC20B cdc20-like protein

FHIT fragile histidine triad gene

CCDC123 hypothetical protein flj14640

HBS1 L hbs1-like (s. cerevisiae)

FAT3 fat tumor suppressor homolog 3 (drosophila)

SSR1 signal sequence receptor, alpha (translocon-associated protein alpha)

CCDC144B hypothetical protein flj36492

NSMCE2 chromosome 8 open reading frame 36

LRBA Ips-responsive vesicle trafficking, beach and anchor containing

PNPT1 polyribonucleotide nucleotidyltransferase 1

CEP63 centrosomal protein 63kda

MACR0D2 chromosome 20 open reading frame 133

ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ergic) 1

CENPE centromere protein e, 312kda

C12orf42 chromosome 12 open reading frame 42

PPP1 R14C protein phosphatase 1 , regulatory (inhibitor) subunit 14c

C17orf57 chromosome 17 open reading frame 57

EIF2C2 eukaryotic translation initiation factor 2c, 2

PPFIBP2 ptprf interacting protein, binding protein 2 (liprin beta 2)

MYRIP myosin viia and rab interacting protein

CYP27B1 cytochrome p450, family 27, subfamily b, polypeptide 1

GPR37L1 g protein-coupled receptor 37 like 1

TNFRSF11 B tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

CABP1 calcium binding protein 1 (calbrain)

PTPRT protein tyrosine phosphatase, receptor type, t

MAPK10 mitogen-activated protein kinase 10

RGNEF rho-guanine nucleotide exchange factor

F0XP1 forkhead box p1

SVEP1 sushi, von willebrand factor type a, egf and pentraxin domain containing 1

VO

KIAA0774 kiaaO774

GALNAC4S-6ST kiaaO598 gene product

NPAS3 neuronal pas domain protein 3

HGD homogentisate 1 ,2-dioxygenase (homogentisate oxidase)

KHDRBS2 kh domain containing, rna binding, signal transduction associated 2

EY A4 eyes absent homolog 4 (drosophila)

SEMA3A sema domain, immunoglobulin domain (ig), short basic domain, secreted, (semaphorin) 3a

HPSE2 heparanase 2

KCNH7 potassium voltage-gated channel, subfamily h (eag-related), member 7

RIMBP2 rims binding protein 2

CACNA1C calcium channel, voltage-dependent, I type, alpha 1c subunit

ACCN 1 amiloride-sensitive cation channel 1 , neuronal (degenerin)

PCDH7 bh-protocadherin (brain-heart)

TNS3 tensin 3

LIPA lipase a, lysosomal acid, cholesterol esterase (wolman disease)

RSU1 ras suppressor protein 1

NCK2 nek adaptor protein 2

ACLY atp citrate lyase

SHMT1 serine hydroxymethyltransferase 1 (soluble)

CWF19L2 cwf19-like 2, cell cycle control (s. pombe)

GLIS3 glis family zinc finger 3

CNBD1 cyclic nucleotide binding domain containing 1

LL22NC03-75B3.6 kiaa1644 protein

TNFAIP8L3 tumor necrosis factor, alpha-induced protein 8-like 3

IL1 F8 interleukin 1 family, member 8 (eta)

FAM 14B family with sequence similarity 14, member b

ALDH8A1 aldehyde dehydrogenase 8 family, member a1

PDE7B phosphodiesterase 7b

R0R2 receptor tyrosine kinase-like orphan receptor 2

IP09 importin 9

WASL wiskott-aldrich syndrome-like

WDR 19 wd repeat domain 19

SAMD12 sterile alpha motif domain containing 12

BAG5 bcl2-associated athanogene 5

SGCZ sarcoglycan zeta

GLTP glycolipid transfer protein

MAP2K5 mitogen-activated protein kinase kinase 5

NRXN3 neurexin 3

MVK mevalonate kinase (mevalonic aciduria)

PHF17 phd finger protein 17 κ> DSCAM L 1 down syndrome cell adhesion molecule like 1

LRRC4C leucine rich repeat containing 4c

SERPINB5 serpin peptidase inhibitor, clade b (ovalbumin), member 5

C0G7 component of oligomeric golgi complex 7

ASTN2 astrotactin 2

ADAM 12 adam metallopeptidase domain 12 (meltrin alpha)

ATXN 10 ataxin 10

FSIP1 fibrous sheath interacting protein 1

DAB1 disabled homolog 1 (drosophila)

DNAJC7 dnaj (hsp40) homolog, subfamily c, member 7

TRAM1 translocation associated membrane protein 1

RNF149 ring finger protein 149

IFRD1 interferon-related developmental regulator 1

CLTC clathrin, heavy polypeptide (he)

IGHMBP2 immunoglobulin mu binding protein 2

NFIB nuclear factor i/b

LIMS1 lim and senescent cell antigen-like domains 1

FLJ14213 hypothetical protein f Ij 14213

NRG1 neuregulin 1

RAD54B fibrinogen silencer binding protein

EIF4E2 eukaryotic translation initiation factor 4e member 2

FLJ46365 flj46365 protein

PDE9A phosphodiesterase 9a

PKN0X2 pbx/knotted 1 homeobox 2

DDX24 dead (asp-glu-ala-asp) box polypeptide 24

ADAMTS12 adam metallopeptidase with thrombospondin type 1 motif, 12

WDR93 hypothetical protein from euroimage 384293

MCC mutated in colorectal cancers

PLCXD3 phosphatidylinositol-specific phospholipase c, x domain containing 3

SCHIP1 schwannomin interacting protein 1

LING02 leucine rich repeat neuronal 6c

SMEK2 kiaai 387 protein

PAX9 paired box gene 9

TCF21 transcription factor 21

ERC2 caz-associated structural protein

FAM59A family with sequence similarity 59, member a

PDE3A phosphodiesterase 3a, cgmp-inhibited

NGEF neuronal guanine nucleotide exchange factor

SIAH 1 seven in absentia homolog 1 (drosophila)

GRM8 glutamate receptor, metabotropic 8

VO

FREM1 frasi related extracellular matrix 1

C9orf135 otthump00000021439

C10orf26 chromosome 10 open reading frame 26

C0L15A1 collagen, type xv, alpha 1

LARGE like-glycosyltransferase

IRF2 interferon regulatory factor 2

WDR47 wd repeat domain 47

DPYS dihydropyrimidinase

BCAS1 breast carcinoma amplified sequence 1

SP0CK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

SLC5A4 solute carrier family 5 (low affinity glucose cotransporter), member 4

ALPK2 alpha-kinase 2

CD300LB cd300 antigen like family member b

CENTG1 phosphoinositide 3-kinase enhancer

RASSF8 ras association (ralgds/af-6) domain family 8

RBPMS rna binding protein with multiple splicing

EGLN1 egl nine homolog 1 (c. elegans)

GALNT5 udp-n-acetyl-alpha-d-galactosamineipolypeptide n-acetylgalactosaminyltransferase 5 (galnac-t5)

GRAMD3 gram domain containing 3

SLC35F3 solute carrier family 35, member f3

TIPRL tip41 , tor signalling pathway regulator-like (s. cerevisiae)

MGAM maltase-glucoamylase (alpha-glucosidase)

STK39 serine threonine kinase 39 (ste20/sps1 homolog, yeast)

CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20

AGTR1 angiotensin ii receptor, type 1

FLJ35776 hypothetical protein Ioc649446

COX4NB cox4 neighbor

UBE3B ubiquitin protein ligase e3b

MGC48628 similar to kiaa1680 protein

RECK reversion-inducing-cysteine-rich protein with kazal motifs

WDR70 wd repeat domain 70

SPHKAP sphki (sphingosine kinase type 1) interacting protein

COL14A1 collagen, type xiv, alpha 1 (undulin)

NRG3 neuregulin 3

TOP3A topoisomerase (dna) iii alpha

GABRG1 gamma-aminobutyric acid (gaba) a receptor, gamma 1

KCTD15 potassium channel tetramerisation domain containing 15

RNF152 ring finger protein 152

CCBE1 collagen and calcium binding egf domains 1

SPTLC3 chromosome 20 open reading frame 38

SLC6A17 hypothetical protein Ioc284462

FLJ46361 flj46361 protein

SPAG16 sperm associated antigen 16

RORA rar-related orphan receptor a

FHL5 four and a half Hm domains 5

OVOL1 ovo-like 1(drosophila)

ADAMTS17 adam metallopeptidase with thrombospondin type 1 motif, 17

ANKFN1 ankyrin-repeat and fibronectin type iii domain containing 1

ALK anaplastic lymphoma kinase (ki-1)

CHN2 chimerin (chimaerin) 2

UHRF1 ubiquitin-like, containing phd and ring finger domains, 1

SEMA7A semaphorin 7a, gpi membrane anchor (John milton hagen blood group)

PLA2G4C phospholipase a2, group ivc (cytosolic, calcium-independent)

NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like

KCNMA1 potassium large conductance calcium-activated channel, subfamily m, alpha member 1

SOX5 sry (sex determining region y)-box 5

DKK2 dickkopf homolog 2 (xenopus laevis)

GRIN2A glutamate receptor, ionotropic, n-methyl d-aspartate 2a

PARK2 parkinson disease (autosomal recessive, juvenile) 2, parkin

ABCC4 atp-binding cassette, sub-family c (cftr/mrp), member 4

GZMA granzyme a (granzyme 1 , cytotoxic t-lymphocyte-associated serine esterase 3)

CACHD1 cache domain containing 1

DYNC2H1 dynein, cytoplasmic 2, heavy chain 1

C10orf81 chromosome 10 open reading frame 81

MPPED2 metallophosphoesterase domain containing 2

RHEB ras homolog enriched in brain

HPCAL4 hippocalcin like 4

C1orf141 chromosome 1 open reading frame 141

LOXL2 lysyl oxidase-like 2

APBB2 amyloid beta (a4) precursor protein-binding, family b, member 2 (fe65-like)

SFRS12IP1 p18srp protein

FARP1 ferm, rhogef (arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)

XYLB xylulokinase homolog (h. influenzae)

RAD50 rad50 homolog (s. cerevisiae)

LOC91431 prematurely terminated mrna decay factor-like

GGA2 golgi associated, gamma adaptin ear containing, arf binding protein 2

PCDH 15 protocadherin 15

NAP5 nck-associated protein 5

LAMB3 laminin, beta 3

CPNE8 copine viii

Ul MACF1 microtubule-actin crosslinking factor 1

NR3C2 nuclear receptor subfamily 3, group c, member 2

ABLIM3 actin binding lim protein family, member 3

RAP1 GDS1 rap1 , gtp-gdp dissociation stimulator 1

FBXW4 f-box and wd-40 domain protein 4

PAPPA pregnancy-associated plasma protein a, pappalysin 1

GARNL3 gtpase activating rap/rangap domain-like 3

LOXHD1 lipoxygenase homology domains 1

SLC22A16 solute carrier family 22 (organic cation transporter), member 16

DEK dek oncogene (dna binding)

SCML4 sex comb on midleg-like 4 (drosophila)

DENND2A denn/madd domain containing 2a

SORCS2 sortilin-related vps10 domain containing receptor 2

IREB2 iron-responsive element binding protein 2

LRRIQ1 leucine-rich repeats and iq motif containing 1

FOXN4 forkhead box n4

SP100 sp100 nuclear antigen

DYM dymeclin

PDE11A phosphodiesterase 11a

BARX2 barh-like homeobox 2

PDZRN3 pdz domain containing ring finger 3

MRPL39 mitochondrial ribosomal protein I39

FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)

CHD1 L chromodomain helicase dna binding protein 1-like

LRRCC1 leucine rich repeat and coiled-coil domain containing 1

CHL1 cell adhesion molecule with homology to 11 cam (close homolog of 11)

MDGA2 mam domain containing 1

ACBD5 acyl-coenzyme a binding domain containing 5

MFSD5 major facilitator superfamily domain containing 5

COL6A3 collagen, type vi, alpha 3

MMP2 matrix metallopeptidase 2 (gelatinase a, 72kda gelatinase, 72kda type iv collagenase)

TACC2 transforming, acidic coiled-coil containing protein 2

CADPS ca2+-dependent secretion activator

ABHD13 chromosome 13 open reading frame 6

NRCAM neuronal cell adhesion molecule

ZNF521 zinc finger protein 521

UBFD1 ubiquitin-binding protein homolog

CR0CCL2 kiaa1922 protein

KIAA0241 kiaaO241

GRHL2 grainyhead-like 2 (drosophila)

CYP39A1 cytochrome p450, family 39, subfamily a, polypeptide 1

TMEM135 hypothetical protein flj22104

SGIP1 sh3-domain grb2-like (endophilin) interacting protein 1

LY75 lymphocyte antigen 75

PGM2L1 phosphoglucomutase 2-like 1

GPC6 glypican 6

EARS2 kiaa1970 protein

SLC6A2 solute carrier family 6 (neurotransmitter transporter, noradrenaline member 2

ARSG arylsulfatase g

KIAA1217 kiaa1217

CDH9 cadherin 9, type 2 (t1-cadherin)

MFSD1 major facilitator superfamily domain containing 1

WWOX putative oxidoreductase

TMPRSS4 type ii membrane serine protease

AC01 aconitase 1 , soluble

NEK11 nima (never in mitosis gene a)- related kinase 11

ATRNL1 attractin-like 1

ADARB1 adenosine deaminase, rna-specific, b1 (red1 homolog rat)

PKIG protein kinase (camp-dependent, catalytic) inhibitor gamma

EME1 essential meiotic endonuclease 1 homolog 1 (s. pombe)

D0K6 docking protein 6

C4orf31 hypothetical protein flj23191

DGAT1 diacylglycerol o-acyltransferase homolog 1 (mouse)

ANXA13 annexin a13

0PN5 opsin 5

0DZ2 odz, odd oz/ten-m homolog 2 (drosophila)

KLHDC4 kelch domain containing 4

MY01 D myosin id

CLU clusterin

TXNDC5 thioredoxin domain containing 5

TDG thymine-dna glycosylase

TMEM117 transmembrane protein 117

AZIN1 antizyme inhibitor 1

LAMB4 laminin, beta 4

MY0M1 myomesin 1 (skelemin) 185kda

ZNF385D zinc finger protein 659

SLC35F4 solute carrier family 35, member f4

GALNTL4 udp-n-acetyl-alpha-d-galactosamineipolypeptide n-acetylgalactosaminyltransferase-like 4

SLC17A5 solute carrier family 17 (anion/sugar transporter), member 5

VO CNTN3 contactin 3 (plasmacytoma associated)

KIDINS220 kinase d-interacting substance of 220 kda

DCC deleted in colorectal carcinoma

ALDH1A1 aldehyde dehydrogenase 1 family, member a1

TRPM3 transient receptor potential cation channel, subfamily m, member 3

WDFY4 wdfy family member 4

UNC13C unc-13 homolog c (c. elegans)

PDE4D phosphodiesterase 4d, camp-specific (phosphodiesterase e3 dunce homolog, drosophila)

FKBP5 fk506 binding protein 5

SLC22A15 solute carrier family 22 (organic cation transporter), member 15

ACVR1 B activin a receptor, type ib

NAALADL2 n-acetylated alpha-linked acidic dipeptidase-like 2

APBA1 amyloid beta (a4) precursor protein-binding, family a, member 1 (x11)

HCN 1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1

DLGAP1 discs, large (drosophila) homolog-associated protein 1

ZNF423 zinc finger protein 423

ARL3 adp-ribosylation factor-like 3

CPM carboxypeptidase m

PHACTR1 kiaa1733 protein

KAT5 K (lysine) acetyl transferase 5

KANK1 KN motif and ankyrin repeat domains 1

Table 7

METHOD

ASSUUIA I IUN

RS IO MARSHFIELD TYPE COVARIATES PHENOTYPE CHR P-VALUE OR ALL rs 17334370 109.1 logistic HBP microalbuminuria vs. no albuminuria (at entry) 5 7.10E-23 1.92 rs17334370 109.1 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) . 5 4.50E-19 1.92 rs17334370 109.1 logistic GE, AGE, SEX microalbuminuria vs. no albuminuria (at entry) 5 3.88E-12 1.92 rs1526591 71.7 logistic HBP microalbuminuria vs. no albuminuria (at entry) 3 1.55E-11 2.27 rs17334370 109.1 logistic microalbuminuria vs. no albuminuria (at entry) 5 2.36E-11 1.92 rs17334370 109.1 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 5 3.29E-11 1.92 rs16973718 45.4 logistic HBP microalbuminuria vs. no albuminuria (at entry) 16 4.84E-10 2.42 rs1526591 71.7 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 3 1.51 E-09 2.27 rs1526591 71.7 logistic microalbuminuria vs. no albuminuria (at entry) 3 4.14E-09 2.27 rs1526591 71.7 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 3 6.76E-09 2.27 rs16973718 45.4 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 16 1.53E-08 2.42 rs1526591 71.7 logistic GE, AGE, SEX microalbuminuria vs. no albuminuria (at entry) 3 3.42E-08 2.27 rs6582 38.4 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 15 5.30E-08 1.66 rs4923876 38.4 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 15 6.21 E-08 1.66 rs4924481 38.4 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 15 6.21 E-08 1.66 00 rs2412531 38.4 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 15 6.36E-08 1.66 rs7842637 114.8 logistic HBP microalbuminuria vs. no albuminuria (at entry) 8 1.05E-07 2.31 rs2396328 226.9 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 2 1.36E-07 0.68 rs2396328 226.9 logistic microalbuminuria vs. no albuminuria (at entry) 2 1.41 E-07 0.68 rs4923872 38.3 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 15 2.54E-07 1.62 rs 11070285 38.5 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 15 2.76E-07 1.62 rs11246628 58.7 logistic HBP microalbuminuria vs. no albuminuria (at entry) 11 2.78E-07 2.15 rs11848645 37.9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 14 3.65E-07 1.46 rs6429453 275.7 logistic low glomerular fitration rate vs. control (at entry) 1 3.93E-07 1.98 rs3820821 46.6 logistic HBP microalbuminuria vs. no albuminuria (at entry) 2 4.10E-07 0.43 rs6582 38.4 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 15 4.42E-07 1.66 rs2412531 38.4 logistic low glomerular fitration rate vs. control (at entry) 15 5.15E-07 1.66 rs4923876 38.4 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 15 5.29E-07 1.66 rs4924481 38.4 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 15 5.29E-07 1.66 rs17680905 43.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 4 5.64E-07 0.62 rs4923876 38.4 logistic low glomerular fitration rate vs. control (at entry) 15 5.67E-07 1.66 rs6582 38.4 logistic low glomerular fitration rate vs. control (at entry) 15 5.67E-07 1.66 rs4924481 38.4 logistic low glomerular fitration rate vs. control (at entry) 15 5.67E-07 1.66 rs2412531 38.4 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 15 5.94E-07 1.66 rs17680407 43.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 4 6.44E-07 0.62

rs1545741 93 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 7 08E-07 233 rs2396328 226 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 7 51 E-07 068 rs16825771 226 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 1 20E-06 069 rs16825771 226 9 logistic microalbuminuria vs no albuminuria (at entry) 2 1 20E-06 069 rs4923872 38 3 logistic GE, AGE, SEX low glomerular Titration rate vs control (at entry) 15 1 37E-06 162 rs7842637 114 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 8 1 39E-06 231 rs3820821 46 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 1 42E-06 043 rs7842637 114 8 logistic microalbuminuria vs no albuminuria (at entry) 8 1 51 E-06 231 rs16973718 454 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 16 1 55E-06 242 rs17680905 43 3 logistic microalbuminuria or macroalbuminuπa vs control (follow-up) 4 1 60E-06 062 rs4586627 226 9 logistic microalbuminuria vs no albuminuria (at entry) 2 1 65E-06 070 rs4586627 226 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 1 65E-06 070 rs 1452420 38 5 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 2 1 68E-06 1 38 rs12973797 58 8 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 19 1 71 E-06 0 63 rs17680407 43 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 4 1 85E-06 0 62 rs4923872 38 3 logistic low glomerular fitration rate vs control (at entry) 15 1 89E-06 1 62 rs10498537 89 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 14 1 92E-06 0 68 rs7842637 114 8 logistic HBP ₁ diabetes duration microalbuminuria vs no albuminuria (at entry) 8 1 97E-06 2 31 rs12403846 248 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 1 98E-06 055 rs7842637 114 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 8 2 16E-06 2 31

VO rs 17680905 43 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 2 22E-06 0 64 rs11070285 38 5 logistic low glomerular fitration rate vs control (at entry) 15 2 24E-06 1 62 rs246277 130 3 logistic albuminuria vs no albuminuria (at entry) 5 2 26E-06 1 58 rs4643103 84 9 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 11 2 39E-06 1 55 rs4931059 53 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 2 43E-06 249 rs11070285 38 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 15 2 47E-06 1 62 rs246277 130 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 2 51 E-06 1 58 rs17597688 112 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 11 2 55E-06 1 84 rs17171382 141 4 logistic low glomerular fitration rate vs control (follow-up) 5 2 60E-06 2 15 rs7535769 191 8 logistic microalbuminuria vs no albuminuria (at entry) 1 2 61 E-06 1 44 rs10498537 89 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 14 2 66E-06 068 rs16880395 43 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 2 68E-06 064 rs12973797 58 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 19 2 93E-06 0 63 rs246277 130 3 logistic microalbuminuria vs no albuminuria (at entry) 5 2 99E-06 1 62 rs 184255 131 4 logistic macroalbuminuria vs no albuminuria (at entry) 9 306E-06 5 72 rs6478513 131 5 logistic macroalbuminuria vs no albuminuria (at entry) 9 309E-06 5 71 rs2962615 5 9 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 316E-06 1 40 rs12599351 124 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 16 325E-06 0 75 rs17680407 43 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 331E-06 0 65 rs1351887 105 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 18 332E-06 0 47

rs12590361 132 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 14 3 36E-06 1 63 rs7535769 191 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 3 49E-06 1 44 rs2144825 132 4 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 14 3 63E-06 1 42 rs6429453 275 7 logistic low creatinine clearance vs normal creatinine clearance 1 3 64E-06 1 62 rs1452420 38 5 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 2 3 67E-06 1 38 rs11857247 384 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 15 3 70E-06 1 50 rs17680905 43 3 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 4 3 77E-06 0 64 rs191606 191 8 logistic microalbuminuria vs no albuminuria (at entry) 1 3 78E-06 1 43 rs11857247 38 4 logistic low creatinine clearance vs normal creatinine clearance 15 3 82E-06 1 50 rs246277 130 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 3 83E-06 1 62 rs2396328 226 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 3 87E-06 0 73 rs11848645 37 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 14 3 88E-06 1 46 rs184255 131 4 logistic AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 9 3 93E-06 5 72 rs191606 191 8 logistic albuminuria vs no albuminuria (at entry) 1 3 93E-06 1 40 rs12590361 132 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 14 3 94E-06 1 63 rs6478513 131 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 3 98E-06 5 71 rs2396328 226 9 logistic albuminuria vs no albuminuria (at entry) 2 4 11 E-06 0 73 rs7029315 102 5 logistic macroalbuminuria vs no albuminuria (at entry) 9 4 25E-06 2 20 rs7203172 48 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 4 37E-06 0 54

4- rs28891 130 3 logistic albuminuria vs no albuminuria (at entry) 5 4 41 E-06 1 57 rs11848645 37 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 4 47E-06 1 38 rs191606 191 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 4 50E-06 1 40 rs28891 130 3 logistic microalbuminuria vs no albuminuria (at entry) 5 4 50E-06 1 62 rs11246628 58 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 11 4 73E-06 2 15 rs16973718 45 4 logistic microalbuminuria vs no albuminuria (at entry) 16 4 84E-06 2 42 rs16825771 226 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 4 85E-06 0 69 rs28891 130 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 4 86E-06 1 57 rs7047415 102 5 logistic macroalbuminuria vs no albuminuria (at entry) 9 4 89E-06 2 20 rs16910240 102 5 logistic macroalbuminuria vs no albuminuria (at entry) 9 4 89E-06 2 20 rs11848645 37 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 14 4 99E-06 1 46 rs9634125 17 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 5 03E-06 0 42 rs191606 191 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 5 14E-06 1 43 rs4586627 226 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 5 18E-06 0 70 rs11688740 800 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 5 20E-06 1 57 rs7535769 191 8 logistic albuminuria vs no albuminuria (at entry) 1 5 21 E-06 1 39 rs6701181 262 8 logistic low glomerular fitration rate vs control (follow-up) 1 5 41 E-06 0 62 rs2964003 156 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 5 56E-06 1 51 rs16880395 43 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 5 60E-06 0 66 rs1558533 17 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 5 74E-06 0 43 rs17680407 43 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 4 5 75E-06 0 65

rs7535769 191 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 5 76E-06 1 39 rs10851396 38 4 logistic AGE, SEX low glomerular titration rate vs control (at entry) 15 5 77E-06 1 58 rs11070279 38 4 logistic AGE, SEX low glomerular Titration rate vs control (at entry) 15 5 84E-06 1 57 rs28891 130 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 5 85E-06 1 62 rs7972470 17 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 5 88E-06 0 43 rs682970 29 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 10 5 89E-06 2 53 rs12973797 58 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 19 6 05E-06 0 63 rs2962615 5 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 6 05E-06 1 40 rs10915955 242 2 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 1 6 11 E-06 1 57 rs17680905 43 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 6 14E-06 0 62 rs9908767 44 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 17 6 16E-06 0 67 rs17334370 109 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 6 23E-06 0 26 rs6429453 275 7 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 1 6 40E-06 1 62 rs11857247 384 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 15 6 41 E-06 1 50 rs4924481 38 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 15 6 42E-06 1 42 rs1558532 17 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 6 48E-06 0 43 rs2926862 156 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 6 57E-06 1 51 rs7029315 102 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 6 59E-06 2 20 rs6444003 196 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 3 6 66E-06 2 05 rs16880395 43 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 4 6 75E-06 0 64 rs4321205 38 9 logistic low glomerular titration rate vs control (follow-up) 16 6 76E-06 0 62 rs4280249 38 9 logistic low glomerular titration rate vs control (follow-up) 16 6 76E-06 0 62 rs4369676 38 9 logistic low glomerular titration rate vs control (follow-up) 16 6 76E-06 0 62 rs4923876 38 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 15 6 86E-06 1 42 rs17680407 43 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 6 90E-06 0 62 rs7302914 17 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 6 96E-06 0 44 rs9908767 44 1 logistic albuminuria vs no albuminuria (at entry) 17 7 03E-06 0 67 rs2144825 132 4 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 14 7 04E-06 1 42 rs2013004 48 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 9 7 06E-06 1 43 rs11857247 38 4 logistic AGE, SEX low glomerular titration rate vs control (at entry) 15 7 24E-06 1 57 rs7317112 744 logistic HBP microalbuminuria vs no albuminuria (at entry) 13 7 24E-06 0 74 rs16973718 454 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 16 7 33E-06 2 42 rs6948497 121 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 7 36E-06 1 89 rs10792617 84 9 logistic AGE, SEX low glomerular titration rate vs control (at entry) 11 7 43E-06 1 53 rs10989294 102 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 7 44E-06 0 54 rs6582 38 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 15 7 51 E-06 1 42 rs10989294 102 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 9 7 58E-06 0 54 rs4600972 135 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 4 7 60E-06 1 48 rs16910240 102 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 7 66E-06 2 20 rs7047415 102 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 7 68E-06 2 20

rs11848645 37 9 logistic microalbuminuria vs no albuminuria (at entry) 14 7 71 E-06 1 38 rs4321205 38 9 logistic GE, AGE, SEX low glomerular Titration rate vs control (follow-up) 16 7 84E-06 0 62 rs4369676 38 9 logistic GE, AGE, SEX low glomerular Titration rate vs control (follow-up) 16 7 84E-06 0 62 rs4280249 38 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 16 7 84E-06 062 rs2171304 7 7 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 10 7 85E-06 0 69 rs7203172 48 8 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 16 7 92E-06 0 54 rs17680905 43 3 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 7 94E-06 0 57 rs17597688 112 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 11 7 97E-06 1 84 rs17597688 112 8 logistic albuminuria vs no albuminuria (follow-up) 11 8 00E-06 1 84 rs9634125 17 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 8 03E-06 0 42 rs6585304 134 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 10 8 14E-06 0 38 rs4869544 54 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 5 8 19E-06 1 32 rs17680905 43 3 logistic low glomerular fitration rate vs control (follow-up) 4 8 27E-06 0 57 rs11848645 37 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 8 28E-06 1 38 rs11054878 17 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 8 29E-06 043 rs17334370 109 1 logistic macroalbuminuria vs no albuminuria (at entry) 5 8 38E-06 0 26 rs17399090 91 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 8 45E-06 0 66 rs2412531 38 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 15 8 60E-06 1 42 rs11054588 17 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 8 64E-06 0 43 rs17334370 109 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 8 77E-06 1 47

O rs2088707 144 0 logistic low glomerular fitration rate vs control (follow-up) 12 8 81 E-06 2 28 rs2964003 156 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 8 91 E-06 1 51 rs7302914 17 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 8 97E-06 0 44 rs11688740 80 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 2 9 08E-06 1 57 rs16880395 43 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 4 9 24E-06 0 66 rs2932966 364 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 9 28E-06 1 41 rs2789417 1664 logistic albuminuria vs no albuminuria (at entry) 1 9 30E-06 0 55 rs11060924 163 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 9 39E-06 0 49 rs7302914 17 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 9 40E-06 0 44 rs2789417 1664 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 9 50E-06 0 55 rs11857247 38 4 logistic low glomerular fitration rate vs control (at entry) 15 9 51 E-06 1 57 rs11848645 37 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 14 9 62E-06 1 33 rs2926862 156 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 9 80E-06 1 51 rs1558533 17 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 9 84E-06 0 43 rs17680407 43 3 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 9 89E-06 0 58 rs1545741 93 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 9 90E-06 2 33 rs9634125 17 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 9 91 E-06 0 42 rs10492295 94 1 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 9 92E-06 3 99 rs8115737 35 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 20 9 92E-06 0 30 rs281243 449 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 15 9 99E-06 1 68

rs6585304 134 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 10 9 99E-06 0 38 rs6582 38 4 logistic AGE ₁ SEX low glomerular fitration rate vs control (follow-up) 15 1 00E-05 1 54 rs7972470 17 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 1 01 E-05 0 43 rs937527 134 5 logistic microalbuminuria vs no albuminuria (at entry) 12 1 01 E-05 1 49 rs11070279 38 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 15 1 01 E-05 1 48 rs7535769 191 8 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 1 02E-05 1 48 rs4643103 84 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 11 1 03E-05 1 55 rs281243 44 9 logistic macroalbuminuria vs no albuminuria (at entry) 15 1 03E-05 1 68 rs11735854 43 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 1 03E-05 0 67 rs1453183 38 4 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 15 1 03E-05 1 56 rs7748736 11 5 logistic albuminuria vs no albuminuria (follow-up) 6 1 04E-05 1 35 rs12403846 248 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 1 05E-05 0 55 rs6761875 45 0 logistic low glomerular titration rate vs control (follow-up) 2 1 07E-05 1 70 rs10511350 130 6 logistic AGE ₁ SEX low creatinine clearance vs normal creatinine clearance 3 1 10E-05 1 59 re1558532 17 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 1 10E-05 0 43 rs7748736 11 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 1 11 E-05 1 35 rs17680407 43 3 logistic low glomerular fitration rate vs control (follow-up) 4 1 11 E-05 0 58 rs1452420 38 5 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 1 12E-05 1 33 rs12485415 42 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 1 12E-05 2 15 rs1558533 17 0 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 1 14E-05 0 43

O rs4643103 84 9 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 11 1 15E-05 1 57 rs1558531 17 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 1 15E-05 0 43 rs16824208 130 6 logistic AGE ₁ SEX low creatinine clearance vs normal creatinine clearance 3 1 16E-05 1 60 rs10511350 130 6 logistic GE ₁ AGE ₁ SEX low creatinine clearance vs normal creatinine clearance 3 1 16E-05 1 59 rs7972470 17 0 logistic GE ₁ AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 1 17E-05 0 43 rs7029315 102 5 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 9 1 18E-05 2 20 rs10934313 130 6 logistic AGE ₁ SEX low creatinine clearance vs normal creatinine clearance 3 1 19E-05 1 59 rs10804520 130 6 logistic AGE ₁ SEX low creatinine clearance vs normal creatinine clearance 3 1 19E-05 1 59 rs10804520 130 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 1 19E-05 1 59 rs2964003 156 8 logistic microalbuminuria vs no albuminuria (at entry) 5 1 19E-05 1 51 rs11070279 38 4 logistic low creatinine clearance vs normal creatinine clearance 15 1 19E-05 1 48 rs16824208 130 6 logistic GE ₁ AGE ₁ SEX low creatinine clearance vs normal creatinine clearance 3 1 21 E-05 1 60 rs1558532 17 0 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 1 23E-05 0 43 rs6585304 134 1 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 10 1 23E-05 0 41 rs2350786 142 6 logistic AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 7 1 24E-05 1 71 rs10934313 130 6 logistic GE ₁ AGE, SEX low creatinine clearance vs normal creatinine clearance 3 1 24E-05 1 59 rs2926862 156 8 logistic microalbuminuria vs no albuminuria (at entry) 5 1 24E-05 1 51 rs7535769 191 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 1 24E-05 1 48 rs6493278 44 9 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 15 1 25E-05 1 67 rs937527 134 5 logistic albuminuria vs no albuminuria (at entry) 12 1 25E-05 1 44

rs2171304 77 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 10 1 25E-05 0 69 rs6564988 110 7 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 1 26E-05 2 31 rs191606 191 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 1 27E-05 1 47 rs2932966 36 4 logistic albuminuria vs no albuminuria (follow-up) 4 1 31 E-05 1 41 rs9351816 84 1 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 1 31 E-05 1 66 rs9354486 82 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 1 32E-05 0 74 rs2350786 142 6 logistic macroalbuminuria vs no albuminuria (at entry) 7 1 33E-05 1 71 rs2419533 131 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 4 1 33E-05 1 67 rs7748736 11 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 1 34E-05 1 35 rs11054878 17 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 1 35E-05 0 43 rs937527 134 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 1 35E-05 1 49 rs16910240 102 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 1 35E-05 2 20 rs682970 29 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 10 1 39E-05 2 53 rs4235846 98 9 logistic low glomerular fitration rate vs control (at entry) 6 1 39E-05 1 73 rs246277 130 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 1 40E-05 1 58 rs2013004 48 0 logistic albuminuria vs no albuminuria (follow-up) 9 1 41 E-05 1 43 rs6429453 275 7 logistic low glomerular fitration rate vs control (follow-up) 1 1 42E-05 1 87 rs7047415 102 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 1 43E-05 2 20 rs6493278 44 9 logistic macroalbuminuria vs no albuminuria (at entry) 15 1 44E-05 1 67 rs2481628 191 8 logistic microalbuminuria vs no albuminuria (at entry) 1 1 44E-05 1 39 rs10498537 89 1 logistic low creatinine clearance vs normal creatinine clearance 14 1 45E-05 0 68 rs3917768 187 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 1 45E-05 1 44 rs12446492 39 0 logistic low glomerular fitration rate vs control (follow-up) 16 1 45E-05 0 63 rs11054878 17 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 1 47E-05 0 43 rs2267889 120 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 7 1 48E-05 0 39 rs17686287 7 9 logistic low creatinine clearance vs normal creatinine clearance 5 1 50E-05 2 11 rs6564988 110 7 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 1 51 E-05 2 31 rs10223600 24 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 6 1 52E-05 1 58 rs191606 191 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 1 53E-05 1 47 rs10180663 45 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 2 1 54E-05 1 47 rs16825771 226 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 1 54E-05 0 74 rs17600042 108 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 7 1 54E-05 0 45 rs937527 134 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 12 1 54E-05 1 44 rs9502593 11 5 logistic albuminuria vs no albuminuria (follow-up) 6 1 54E-05 1 34 rs10851396 38 4 logistic low glomerular fitration rate vs control (at entry) 15 1 54E-05 1 58 rs7317112 74 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 13 1 55E-05 0 74 rs10851396 38 4 logistic low creatinine clearance vs normal creatinine clearance 15 1 55E-05 1 47 rs17334370 109 1 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 1 55E-05 0 26 rs289450 108 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 15 1 55E-05 0 51 rs11857247 38 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 15 1 56E-05 1 57

rs11070279 38 4 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 15 1 56E-05 1 57 rs2789417 166 4 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (at entry) 1 1 56E-05 0 55 rs1529289 131 7 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 2 1 56E-05 0 63 rs16825771 226 9 logistic albuminuria vs no albuminuria (at entry) 2 1 57E-05 0 74 rs17171382 141 4 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 5 1 58E-05 2 15 rs2962615 5 9 logistic GE ₁ AGE ₁ SEX low glomerular titration rate vs control (at entry) 5 1 58E-05 1 50 rs2789416 166 4 logistic AGE ₁ SEX albuminuria vs no albuminuria (at entry) 1 1 59E-05 0 56 rs2789416 166 4 logistic albuminuria vs no albuminuria (at entry) 1 1 60E-05 0 56 rs11054588 17 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 1 60E-05 0 43 rs11246628 58 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 1 61 E-05 2 15 rs7195806 124 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 1 61 E-05 0 69 rs289450 108 9 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 15 1 62E-05 0 51 rs610414 239 1 logistic GE ₁ AGE, SEX low glomerular titration rate vs control (at entry) 1 1 63E-05 1 48 rs2350786 142 6 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 7 1 64E-05 1 71 rs4331429 82 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 19 1 65E-05 1 68 rs6429453 275 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 1 65E-05 1 62 rs12127748 204 5 logistic low creatinine clearance vs normal creatinine clearance 1 1 67E-05 2 55 rs10471462 68 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 1 68E-05 0 61 rs930056 136 7 logistic GE ₁ AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 1 69E-05 0 54 rs10851396 38 4 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 15 1 70E-05 1 58

O rs9502593 11 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 1 70E-05 1 34 rs6985315 115 8 logistic AGE ₁ SEX low glomerular titration rate vs control (at entry) 8 1 70E-05 0 63 rs1530104 131 7 logistic low glomerular titration rate vs control (at entry) 2 1 71 E-05 0 63 rs10934312 130 6 logistic AGE ₁ SEX low creatinine clearance vs normal creatinine clearance 3 1 71 E-05 1 60 rs1569175 195 7 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 2 1 72E-05 1 62 rs8115737 35 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 20 1 72E-05 0 30 rs246277 130 3 logistic GE ₁ AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 1 72E-05 1 62 rs12599351 124 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 16 1 75E-05 0 75 rs 1558531 17 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 1 75E-05 043 rs10071774 68 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 1 75E-05 0 61 rs11951359 68 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 1 75E-05 0 61 rs17399090 91 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 9 1 76E-05 0 66 rs17006815 47 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 1 76E-05 1 82 rs9323200 53 0 logistic albuminuria vs no albuminuria (follow-up) 14 1 77E-05 1 35 rs10934312 130 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 1 77E-05 1 60 rs9323200 53 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 14 1 78E-05 1 35 rs10465473 248 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 1 79E-05 0 59 rs1529289 131 7 logistic low glomerular titration rate vs control (at entry) 2 1 79E-05 0 63 rs11246628 58 7 logistic microalbuminuria vs no albuminuria (at entry) 11 1 79E-05 2 15 rs2962792 41 1 logistic HBP microalbuminuria vs no albuminuria (at entry) 5 1 80E-05 0 55

rs12485415 42.4 logistic albuminuria vs. no albuminuria (at entry) 3 1.80E-05 2.15 rs7807871 142.5 logistic AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 7 1.82E-05 1.69 rs8115737 35.2 logistic microalbuminuria vs. no albuminuria (at entry) 20 1.83E-05 0.30 rs6472346 83.6 logistic low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 8 1.84E-05 0.53 rs17600042 108.7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 7 1.85E-05 0.45 rs12485415 42.4 logistic AGE, SEX albuminuria vs. no albuminuria (at entry) 3 1.87E-05 2.15 rs7195806 124.7 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 16 1.88E-05 0.69 rs4923872 38.3 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 15 1.88E-05 1.40 rs6673199 127.5 logistic GE, AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 1 1.88E-05 1.95 rs17134277 108.2 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 5 1.89E-05 2.31 rs4331429 82.7 logistic macroalbuminuria vs. no albuminuria (at entry) 19 1.90E-05 1.68 rs1616442 69.9 logistic low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 18 1.91E-05 0.54 rs10851396 38.4 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 15 1.91E-05 1.47 rs6676401 244.5 logistic HBP microalbuminuria vs. no albuminuria (at entry) 1 1.92E-05 2.22 rs10071774 68.7 logistic albuminuria vs. no albuminuria (at entry) 5 1.92E-05 0.66 rs11951359 68.7 logistic albuminuria vs. no albuminuria (at entry) 5 1.92E-05 0.66 rs4923876 38.4 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 15 1.93E-05 1.53 rs4924481 38.4 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 15 1.93E-05 1.53 rs421853 44.9 logistic AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 15 1.93E-05 1.65 rs10498537 89.1 logistic AGE ₁ SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 14

O 1.93E-05 0.72 rs1411442 65.5 logistic macroalbuminuria vs. no albuminuria (at entry) 9 1.93E-05 2.54 rs2412524 38.3 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 15 1.94E-05 1.56 rs8115737 35.2 logistic GE, AGE, SEX microalbuminuria vs. no albuminuria (at entry) 20 1.94E-05 0.30 rs11070279 38.4 logistic low glomerular fitration rate vs. control (at entry) 15 1.95E-05 1.57 rs791743 191.8 logistic microalbuminuria vs. no albuminuria (at entry) 1 1.96E-05 1.38 rs1452420 38.5 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 2 1.97E-05 1.33 rs2396328 226.9 logistic GE, AGE, SEX albuminuria vs. no albuminuria (at entry) 2 1.97E-05 0.73 rs1411441 65.5 logistic macroalbuminuria vs. no albuminuria (at entry) 9 1.97E-05 2.54 rs10180663 45.4 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 2 1.98E-05 1.47 rs11848645 37.9 logistic AGE, SEX albuminuria vs. no albuminuria (at entry) 14 1.98E-05 1.33 rs7203172 48.8 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 16 1.99E-05 0.57 rs4548801 128.6 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 14 1.99E-05 1.45 rs11070279 38.4 logistic GE, AGE, SEX low creatinine clearance vs. normal creatinine clearance 15 2.00E-05 1.48 rs1351887 105.5 logistic AGE ₁ SEX albuminuria vs. no albuminuria (follow-up) 18 2.00E-05 0.47 rs10865331 81.5 logistic low glomerular fitration rate vs. control (follow-up) 2 2.00E-05 1.59 rs12403846 248.3 logistic macroalbuminuria vs. no albuminuria (at entry) 1 2.00E-05 0.55 rs2481628 191.8 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 1 2.00E-05 1.39 rs7807871 142.5 logistic macroalbuminuria vs. no albuminuria (at entry) 7 2.01E-05 1.69 rs4931059 53.5 logistic microalbuminuria vs. no albuminuria (at entry) 12 2.01E-05 2.49 rs10471462 68.7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 5 2.02E-05 0.61

rs6585304 134 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 10 2 02E-05 0 41 rs17334370 109 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 5 2 02E-05 0 60 rs7628779 48 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 3 2 02E-05 1 62 rs11054588 17 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 2 03E-05 0 43 rs2699367 131 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 2 2 04E-05 0 64 rs4548801 128 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 14 2 05E-05 1 45 rs11848645 37 9 logistic albuminuria vs no albuminuria (at entry) 14 2 05E-05 1 33 rs1154436 105 5 logistic low glomerular fitration rate vs control (at entry) 4 2 08E-05 0 62 rs704829 191 8 logistic microalbuminuria vs no albuminuria (at entry) 1 2 08E-05 1 38 rs10482872 4 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 21 2 08E-05 1 95 rs17078168 8 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 2 09E-05 0 51 rs10071774 68 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 2 10E-05 0 66 rs11951359 68 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 2 10E-05 0 66 rs6926642 166 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 2 10E-05 0 73 rs10897992 72 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 2 10E-05 0 59 rs10501407 72 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 2 10E-05 0 59 rs17056214 47 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 13 2 11 E-05 2 03 rs7082102 102 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 10 2 11 E-05 1 36 rs6926642 166 6 logistic microalbuminuria vs no albuminuria (at entry) 6 2 11 E-05 0 73 rs7748736 11 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 6 2 11 E-05 1 46

O rs6585304 134 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 10 2 13E-05 0 38 rs2699367 131 7 logistic low glomerular fitration rate vs control (at entry) 2 2 13E-05 0 64 rs17078168 8 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 8 2 14E-05 0 51 rs10071774 68 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 2 14E-05 0 61 rs11951359 68 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 2 14E-05 0 61 rs6737578 5 7 logistic low creatinine clearance vs normal creatinine clearance 2 2 14E-05 2 52 rs9351816 84 1 logistic macroalbuminuria vs no albuminuria (at entry) 6 2 14E-05 1 66 rs1351887 105 5 logistic albuminuria vs no albuminuria (follow-up) 18 2 15E-05 0 47 rs791743 191 8 logistic albuminuria vs no albuminuria (at entry) 1 2 16E-05 1 35 rs421853 44 9 logistic macroalbuminuria vs no albuminuria (at entry) 15 2 16E-05 1 65 rs1453183 38 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 15 2 17E-05 1 46 rs11070285 38 5 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 15 2 17E-05 1 41 rs4333309 130 3 logistic albuminuria vs no albuminuria (at entry) 5 2 18E-05 1 52 rs1530104 131 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 2 2 18E-05 0 63 rs9351816 84 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 2 18E-05 1 66 rs1453183 38 4 logistic low creatinine clearance vs normal creatinine clearance 15 2 19E-05 1 46 rs6673199 127 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 2 19E-05 1 95 rs2412524 38 3 logistic low glomerular fitration rate vs control (at entry) 15 2 21 E-05 1 56 rs2412531 38 4 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 15 2 23E-05 1 52 rs2057028 60 4 logistic low glomerular fitration rate vs control (at entry) 20 2 24E-05 2 05

rs2481628 191 8 logistic albuminuria vs no albuminuria (at entry) 1 2 25E-05 1 35 rs9502593 11 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 2 25E-05 1 34 rs10897992 72 9 logistic microalbuminuria vs no albuminuria (at entry) 11 2 25E-05 0 59 rs10501407 72 9 logistic microalbuminuria vs no albuminuria (at entry) 11 2 25E-05 0 59 rs11897612 119 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 2 28E-05 1 41 rs4985702 44 2 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 17 2 28E-05 0 69 rs4924481 38 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 15 2 28E-05 1 42 rs4333309 130 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 2 29E-05 1 52 rs4321205 38 9 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 16 2 30E-05 0 62 rs4280249 38 9 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 16 2 30E-05 0 62 rs4369676 38 9 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 16 2 30E-05 0 62 rs4663113 133 4 logistic low glomerular fitration rate vs control (at entry) 2 2 30E-05 1 54 rs9368402 39 2 logistic low creatinine clearance vs normal creatinine clearance 6 2 30E-05 1 45 rs4931059 53 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 2 31 E-05 2 49 rs17006815 47 4 logistic microalbuminuria vs no albuminuria (at entry) 2 2 33E-05 1 82 rs17078168 8 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 8 2 35E-05 0 51 rs1569175 195 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 2 35E-05 1 95 rs1379666 88 6 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 6 2 35E-05 1 69 rs4279411 166 6 logistic microalbuminuria vs no albuminuria (at entry) 6 2 36E-05 0 73 732234 114 5 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up)

O rs2 18 2 36E-05 0 66 OO rs4923876 38 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 15 2 38E-05 1 42 rs17025554 113 2 logistic albuminuria vs no albuminuria (at entry) 2 2 40E-05 0 67 rs1548447 37 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 16 2 41 E-05 1 87 rs11233277 72 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 2 42E-05 0 62 rs4279411 166 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 2 43E-05 0 73 rs7807871 142 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 2 43E-05 1 69 rs9540649 504 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 2 44E-05 0 67 rs28891 130 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 2 44E-05 1 62 rs4931059 53 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 2 44E-05 2 49 rs1526591 71 7 logistic albuminuria vs no albuminuria (at entry) 3 2 44E-05 1 79 rs1461237 156 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 2 45E-05 1 47 rs1986877 55 3 logistic low glomerular fitration rate vs control (at entry) 7 2 46E-05 0 65 rs12403846 248 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 1 2 46E-05 0 75 rs10106008 32 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 8 2 47E-05 0 56 rs10498537 89 1 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 14 2 48E-05 0 72 rs10188434 119 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 2 48E-05 1 40 rs986866 43 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 2 48E-05 0 69 rs2789416 166 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 1 2 49E-05 0 56 rs6948497 121 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 2 50E-05 1 89 rs1558531 17 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 2 50E-05 0 43

rs10495244 242 2 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 1 2 51 E-05 1 54 rs10471462 68 7 logistic albuminuria vs no albuminuria (at entry) 5 2 52E-05 0 66 rs259997 95 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 20 2 52E-05 1 60 rs17600042 108 7 logistic albuminuria vs no albuminuria (at entry) 7 2 53E-05 0 50 rs791743 191 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 2 53E-05 1 35 rs2831543 25 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 21 2 53E-05 0 74 rs11735854 43 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 4 2 55E-05 0 67 rs704829 191 8 logistic albuminuria vs no albuminuria (at entry) 1 2 56E-05 1 35 rs2412524 38 3 logistic low creatinine clearance vs normal creatinine clearance 15 2 57E-05 1 45 rs6582 38 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 15 2 57E-05 1 42 rs4985702 44 2 logistic albuminuria vs no albuminuria (at entry) 17 2 57E-05 0 69 rs28891 130 3 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (at entry) 5 2 57E-05 1 57 rs11246628 58 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 2 57E-05 2 15 rs10070326 8 0 logistic low creatinine clearance vs normal creatinine clearance 5 2 59E-05 2 69 rs3917768 187 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 2 59E-05 1 44 rs2481628 191 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 2 61 E-05 1 35 rs1764844 239 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 1 2 62E-05 1 51 rs4235846 98 9 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 6 2 62E-05 1 73 rs1526591 71 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 3 2 64E-05 1 79 rs11233277 72 9 logistic microalbuminuria vs no albuminuria (at entry) 11 2 64E-05 0 62

O rs9343494 88 6 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs control (follow-up) 6 2 64E-05 1 68 rs7947110 12 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 11 2 65E-05 1 37 rs260011 95 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 2 65E-05 2 40 rs1453183 38 4 logistic low glomerular fitration rate vs control (at entry) 15 2 66E-05 1 56 rs791743 191 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 2 66E-05 1 38 rs4535211 41 8 logistic low glomerular fitration rate vs control (follow-up) 3 2 66E-05 1 55 rs1455857 142 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 2 67E-05 1 63 rs4981158 6 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 14 2 67E-05 0 64 rs7624432 190 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 3 2 68E-05 2 26 rs831663 28 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 5 2 68E-05 1 88 rs9908767 44 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 17 2 68E-05 0 67 rs2053158 101 5 logistic low creatinine clearance vs normal creatinine clearance 17 2 69E-05 1 55 rs2862907 10 3 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 13 2 70E-05 1 61 rs470455 52 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 2 71 E-05 0 69 rs10471462 68 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 2 75E-05 0 66 rs1379666 88 6 logistic low glomerular fitration rate vs control (follow-up) 6 2 78E-05 1 69 rs17025554 113 2 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 2 79E-05 0 67 rs2926862 156 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 2 79E-05 1 42 rs2088707 144 0 logistic low glomerular fitration rate vs control (at entry) 12 2 80 E-05 2 01 rs2699365 131 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 2 2 81 E-05 0 65

rs704829 191 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 2 82E-05 1 38 rs13006847 133 5 logistic low glomerular Titration rate vs control (at entry) 2 2 83E-05 1 52 rs9343494 88 6 logistic low glomerular titration rate vs control (follow-up) 6 2 84E-05 1 68 rs12407408 148 1 logistic albuminuria vs no albuminuria (follow-up) 1 2 84E-05 0 75 rs4548801 128 6 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 14 2 84E-05 1 45 rs7082102 102 6 logistic albuminuria vs no albuminuria (follow-up) 10 2 85E-05 1 36 rs9502593 11 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 6 2 85E-05 1 45 rs10501407 72 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 2 87E-05 0 59 rs10897992 72 9 logistic GE ₁ AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 2 87E-05 0 59 rs9457730 164 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 2 88E-05 1 40 rs17006815 47 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 2 89E-05 1 82 rs869346 91 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 2 89E-05 1 64 rs2831543 25 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 21 2 90E-05 0 74 rs1453183 38 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 15 2 90E-05 1 56 rs12361671 112 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 11 2 90E-05 1 57 rs41530345 66 0 logistic low glomerular fitration rate vs control (at entry) 9 2 90E-05 1 77 rs7761326 82 2 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 2 91 E-05 1 62 rs7808966 180 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 2 92E-05 0 74 rs1229979 105 5 logistic low glomerular fitration rate vs control (at entry) 4 2 93E-05 0 62 rs16901596 138 2 logistic low glomerular fitration rate vs control (at entry) 8 2 93E-05 5 33 rs1455857 142 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 2 93E-05 1 63 rs704829 191 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 2 95E-05 1 35 rs17600042 108 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 7 2 95E-05 0 50 rs9457730 164 6 logistic albuminuria vs no albuminuria (at entry) 6 2 96E-05 1 40 rs11735854 43 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 2 96E-05 0 67 rs2831543 25 7 logistic albuminuria vs no albuminuria (follow-up) 21 2 97E-05 0 74 rs17705657 60 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 19 2 97E-05 1 67 rs7973993 112 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 2 98E-05 1 98 rs2013004 48 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 9 2 99E-05 1 43 rs16851268 216 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 1 2 99E-05 0 67 rs2412531 38 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 15 3 00E-05 1 42 rs2396328 226 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 3 01 E-05 0 71 rs1360411 32 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 3 02E-05 1 45 rs11886084 38 3 logistic low glomerular titration rate vs control (follow-up) 2 3 03E-05 1 57 rs11233277 72 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 3 04E-05 0 62 rs719213 123 8 logistic low glomerular fitration rate vs control (follow-up) 8 3 05E-05 0 58 rs259997 95 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 20 3 05E-05 1 60 rs1411442 65 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 3 06E-05 2 54 rs6673199 127 5 logistic macroalbuminuria vs no albuminuria (at entry) 1 3 07E-05 1 95 rs7747972 82 2 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 3 07E-05 1 62

rs4334629 418 logistic low glomerular fitration rate vs control (follow-up) 3 3 07E-05 0 64 rs7193007 492 logistic microalbuminuria vs no albuminuria (at entry) 16 3 07E-05 1 44 rs7161611 65 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 14 3 08E-05 0 65 rs12713469 81 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 2 3 09E-05 1 30 rs2396328 226 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 3 10E-05 0 68 rs1411441 65 5 logistic AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 9 3 11 E-05 2 54 rs1430373 87 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 3 11 E-05 1 41 rs9457730 164 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 3 12E-05 1 40 rs7193007 49 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 16 3 12E-05 1 44 rs4673727 195 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 3 13E-05 1 91 rs1379666 88 6 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 6 3 13E-05 1 69 rs6861743 108 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 3 13E-05 2 35 rs6501786 101 4 logistic low creatinine clearance vs normal creatinine clearance 17 3 15E-05 1 54 rs1455857 142 5 logistic macroalbuminuria vs no albuminuria (at entry) 7 3 15E-05 1 63 rs16910240 102 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 9 3 16E-05 1 60 rs17258731 146 1 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 3 17E-05 1 57 rs41494550 191 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 1 3 18E-05 0 30 rs980907 50 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 3 18E-05 0 68 rs1548447 37 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 16 3 19E-05 1 87 rs17115571 127 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 3 20E-05 1 92 rs344708 28 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 3 20E-05 0 69 rs7947110 12 7 logistic albuminuria vs no albuminuria (follow-up) 11 3 21 E-05 1 37 rs4535211 41 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 3 3 22E-05 1 53 rs4597881 77 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 3 22E-05 1 52 rs355460 77 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 3 22E-05 1 52 rs869346 91 7 logistic microalbuminuria vs no albuminuria (at entry) 14 3 25E-05 1 64 rs1327210 50 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 3 25E-05 0 68 rs9368793 46 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 6 3 25E-05 0 68 rs4643103 84 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 11 3 25E-05 1 57 rs13006847 133 5 logistic low glomerular fitration rate vs control (follow-up) 2 3 26E-05 1 54 rs2736172 44 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 3 26E-05 1 33 rs9368793 46 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 6 3 27E-05 0 68 rs12895787 91 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 3 27E-05 1 63 rs2144825 132 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 14 3 28E-05 1 37 rs7047415 102 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 9 3 29E-05 1 60 rs2935624 5 9 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 3 29E-05 0 77 rs9354486 82 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 3 30E-05 0 74 rs2699365 131 7 logistic low glomerular fitration rate vs control (at entry) 2 3 30E-05 0 65 rs1452420 38 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 2 3 32E-05 1 49 rs448666 60 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 3 32E-05 0 54

rs2404535 133 5 logistic low glomerular titration rate vs control (at entry) 2 3 33E-05 1 52 rs2396328 226 9 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 2 3 33E-05 0 71 rs17705657 60 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 19 3 34E-05 1 67 rs1333996 26 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 9 3 34E-05 1 52 rs6809087 41 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 3 3 36E-05 1 53 rs6809087 41 8 logistic low glomerular fitration rate vs control (follow-up) 3 3 38E-05 1 54 rs16880395 43 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 3 38E-05 0 64 rs4333309 130 3 logistic microalbuminuria vs no albuminuria (at entry) 5 3 38E-05 1 55 rs17272796 41 8 logistic low glomerular fitration rate vs control (follow-up) 3 3 40E-05 1 54 rs28490018 114 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 14 3 40E-05 0 62 rs7947110 12 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 11 3 41 E-05 1 37 rs12127748 204 5 logistic low glomerular fitration rate vs control (at entry) 1 3 42E-05 3 73 rs4535211 41 8 logistic low glomerular fitration rate vs control (at entry) 3 3 42E-05 1 53 rs10792617 84 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 11 3 43E-05 1 53 rs17705657 60 3 logistic macroalbuminuria vs no albuminuria (at entry) 19 3 43E-05 1 67 rs3809485 45 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 15 3 47E-05 0 71 rs2935624 5 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 3 47E-05 0 77 rs1548447 37 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 16 3 48E-05 1 80 rs9343494 88 6 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 6 3 48E-05 1 68 rs1908329 71 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 3 49E-05 1 33 rs1461237 156 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 3 49E-05 1 47 rs7748736 11 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 3 50E-05 1 41 rs2502845 191 8 logistic microalbuminuria vs no albuminuria (at entry) 1 3 52E-05 1 37 rs3909788 125 5 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 12 3 53E-05 0 62 rs7808966 180 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 3 53E-05 0 74 rs1523890 4 8 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 3 3 55E-05 1 49 rs7193418 18 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 16 3 56E-05 1 95 rs10223600 24 9 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 6 3 57E-05 1 58 rs2964003 156 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 3 57E-05 1 42 rs7748736 11 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 3 58E-05 1 46 rs12458118 76 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 3 58E-05 0 70 rs2736172 44 9 logistic albuminuria vs no albuminuria (at entry) 6 3 58E-05 1 33 rs3858637 65 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 3 59E-05 1 37 rs3809485 45 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 15 3 60E-05 0 71 rs184255 131 4 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 3 61 E-05 5 72 rs7748736 11 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 3 61 E-05 1 41 rs12895787 91 6 logistic microalbuminuria vs no albuminuria (at entry) 14 3 63E-05 1 63 rs10845092 20 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 3 64E-05 0 23 rs6007450 52 1 logistic albuminuria vs no albuminuria (follow-up) 22 3 64E-05 0 65 rs6478513 131 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 3 64E-05 5 71

rs12458118 76 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 3 65E-05 0 70 rs4789188 101 5 logistic low creatinine clearance vs normal creatinine clearance 17 3 65E-05 1 54 rs344708 28 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 3 66E-05 0 69 rs41494550 191 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 3 66E-05 0 30 rs10803476 31 4 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 1 3 69E-05 0 69 rs12055256 130 3 logistic microalbuminuria vs no albuminuria (at entry) 5 3 69E-05 1 54 rs733299 38 3 logistic low glomerular fitration rate vs control (at entry) 15 3 69E-05 1 55 rs1472095 36 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 3 69E-05 1 37 rs2090018 44 2 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 17 3 70E-05 0 70 rs13273013 101 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 3 72E-05 1 41 rs7193007 49 2 logistic albuminuria vs no albuminuria (follow-up) 16 3 73E-05 1 41 rs12536448 28 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 3 74E-05 0 71 rs682970 29 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 10 3 74E-05 2 53 rs7047415 102 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 9 3 75E-05 1 60 rs7761326 82 2 logistic macroalbuminuria vs no albuminuria (at entry) 6 3 75E-05 1 62 rs4643103 84 9 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 11 3 75E-05 1 38 rs17258731 146 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 3 76E-05 1 57 rs17115571 127 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 3 78E-05 1 92 rs2789417 1664 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 3 79E-05 0 53 rs4535211 41 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 3 3 80E-05 1 53

W rs16910240 102 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 9 3 80E-05 1 60 rs7985116 86 0 logistic low creatinine clearance vs normal creatinine clearance 13 3 80E-05 0 69 rs1548447 37 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 16 3 81 E-05 1 80 rs2508492 116 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 3 81 E-05 3 37 rs16830489 204 4 logistic low creatinine clearance vs normal creatinine clearance 1 3 81 E-05 2 47 rs6809087 41 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 3 3 82E-05 1 53 rs1452420 38 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 2 3 82E-05 1 52 rs12407408 148 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 3 88E-05 0 75 rs10492295 94 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 3 89E-05 3 99 rs6809087 41 8 logistic low glomerular fitration rate vs control (at entry) 3 3 90E-05 1 53 rs13273013 101 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 8 3 91 E-05 1 41 rs12119983 221 9 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 3 91 E-05 1 64 rs924640 56 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 3 93E-05 2 13 rs10000497 43 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 3 93E-05 0 70 rs7193007 49 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 16 3 94E-05 1 41 rs2873929 77 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 3 94E-05 1 51 rs7655850 77 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 3 94E-05 1 51 rs7973993 112 5 logistic low glomerular fitration rate vs control (follow-up) 12 3 97E-05 2 17 rs260005 95 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 3 98E-05 2 28 rs2710016 38 3 logistic low glomerular fitration rate vs control (follow-up) 2 3 98E-05 0 65

rs5752554 27 8 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 22 3 98E-05 0 41 rs634585 504 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 3 99E-05 0 68 rs12407408 148 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 1 3 99E-05 0 75 rs4331429 82 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 19 400E-05 1 68 rs7047415 102 5 logistic albuminuria vs no albuminuria (at entry) 9 4 00E-05 1 60 rs16910240 102 5 logistic albuminuria vs no albuminuria (at entry) 9 4 00E-05 1 60 rs782108 71 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 4 01 E-05 1 30 rs6582 38 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 15 4 01 E-05 1 54 rs4931059 53 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 4 01 E-05 2 49 rs937527 134 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 4 02E-05 1 49 rs6713 88 5 logistic macroalbuminuria vs no albuminuria (at entry) 2 4 03E-05 0 57 rs17031374 19 8 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 4 03E-05 1 83 rs2738078 9 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 4 05E-05 0 66 rs10851396 38 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 15 4 06E-05 1 47 rs11185172 140 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 1 4 09E-05 1 30 rs7220293 74 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 17 4 11 E-05 1 17 rs2090018 44 2 logistic albuminuria vs no albuminuria (at entry) 17 4 11 E-05 0 70 rs2962615 5 9 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 5 4 12E-05 1 50 rs454356 95 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 20 4 13E-05 1 58 rs17670198 80 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 4 15E-05 1 35 rs355483 77 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 4 16E-05 1 51 rs4333309 130 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 4 16E-05 1 55 rs7193418 18 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 16 4 16E-05 1 95 rs7747972 82 2 logistic macroalbuminuria vs no albuminuria (at entry) 6 4 17E-05 1 62 rs2412524 38 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 15 4 18E-05 1 56 rs17680905 43 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 4 20E-05 0 57 rs1258241 69 7 logistic low glomerular fitration rate vs control (follow-up) 10 4 21 E-05 0 66 rs1453183 38 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 15 4 23E-05 1 46 rs7203172 48 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 4 23E-05 0 57 rs17272796 41 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 3 4 23E-05 1 52 rs12055256 130 3 logistic albuminuria vs no albuminuria (at entry) 5 4 23E-05 1 49 rs4456715 131 7 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 4 23E-05 0 70 rs281243 44 9 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 15 4 24E-05 1 68 rs1356952 134 5 logistic microalbuminuria vs no albuminuria (at entry) 12 4 24E-05 1 44 rs7668533 77 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 4 26E-05 1 52 rs17022224 59 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 4 26E-05 2 03 rs6948497 121 3 logistic macroalbuminuria vs no albuminuria (at entry) 7 4 29E-05 1 89 rs17680905 43 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 4 30E-05 0 64 rs10792617 84 9 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 11 4 30E-05 1 53 rs4923872 38 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 15 4 30E-05 1 40

rs4775711 45 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 15 4 31 E-05 0 71 rs10106008 32 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 4 31 E-05 0 56 rs7027322 27 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 4 31 E-05 0 68 rs4789189 101 5 logistic low creatinine clearance vs normal creatinine clearance 17 4 33E-05 1 53 rs10091527 123 8 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 4 33E-05 0 66 rs4775711 45 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 15 4 35E-05 0 71 rs8115737 35 2 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 20 4 36E-05 0 40 rs6007450 52 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 22 4 37E-05 0 65 rs10904339 11 5 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (at entry) 10 4 37E-05 0 69 rs2114913 108 9 logistic AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 12 4 38E-05 2 58 rs1866479 131 6 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 2 4 38E-05 0 68 rs4789193 101 5 logistic low creatinine clearance vs normal creatinine clearance 17 4 41 E-05 1 53 rs17076524 145 7 logistic low glomerular Titration rate vs control (at entry) 6 4 43E-05 1 94 rs2592115 239 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 4 44E-05 1 53 rs1430382 87 2 logistic low creatinine clearance vs normal creatinine clearance 18 4 45E-05 0 70 rs4773709 72 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 4 46E-05 1 67 rs12045707 222 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 4 48E-05 1 62 rs2412524 38 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 15 4 48E-05 1 45 rs6493278 44 9 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 15 4 48E-05 1 67 rs41521644 191 7 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 1 4 49E-05 0 50

Ul rs632248 83 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 4 50E-05 1 44 rs2391782 127 6 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 1 4 51 E-05 1 91 rs6582 38 4 logistic low glomerular Titration rate vs control (follow-up) 15 4 51 E-05 1 54 rs12055256 130 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 4 51 E-05 1 49 rs982926 130 3 logistic microalbuminuria vs no albuminuria (at entry) 5 4 52E-05 1 39 rs2646261 252 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 4 53E-05 1 58 rs4128841 251 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 1 4 53E-05 1 44 rs7842637 114 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 8 4 53E-05 1 96 rs17272796 41 8 logistic low glomerular fitration rate vs control (at entry) 3 4 54E-05 1 52 rs17031374 19 8 logistic macroalbuminuria vs no albuminuria (at entry) 3 4 54E-05 1 83 rs17025554 113 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 2 4 57E-05 0 67 rs2205895 187 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 4 58E-05 1 44 rs12045707 222 0 logistic macroalbuminuria vs no albuminuria (at entry) 1 4 59E-05 1 62 rs16880395 43 3 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 4 59E-05 0 61 rs9502593 11 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 4 59E-05 1 40 rs1402337 134 5 logistic microalbuminuria vs no albuminuria (at entry) 12 4 60E-05 1 44 rs12055256 130 3 logistic AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 5 4 60E-05 1 54 rs17031374 19 8 logistic AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 3 4 61 E-05 1 83 rs1461237 156 9 logistic microalbuminuria vs no albuminuria (at entry) 5 4 62E-05 1 47 rs41521644 191 7 logistic microalbuminuria vs no albuminuria (at entry) 1 4 63E-05 0 38

rs9354486 82.3 logistic microalbuminuria vs. no albuminuria (at entry) 6 4.63E-05 0.74 rs9502593 11.5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 6 4.64E-05 1.40 rs10495829 53.5 logistic albuminuria vs. no albuminuria (at entry) 2 4.64E-05 2.23 rs1545653 88.6 logistic HBP microalbuminuria vs. no albuminuria (at entry) 6 4.66E-05 0.44 rs10071774 68.7 logistic microalbuminuria vs. no albuminuria (at entry) 5 4.67E-05 0.65 rs11951359 68.7 logistic microalbuminuria vs. no albuminuria (at entry) 5 4.67E-05 0.65 rs10180663 45.4 logistic low creatinine clearance vs. normal creatinine clearance 2 4.68E-05 1.47 rs10816424 112.5 logistic low glomerular titration rate vs. control (at entry) 9 4.68E-05 1.89 rs10978606 112.5 logistic low glomerular titration rate vs. control (at entry) 9 4.68E-05 1.89 rs4586627 226.9 logistic AGE, SEX albuminuria vs. no albuminuria (at entry) 2 4.69E-05 0.76 rs41521644 191.7 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 1 4.69E-05 0.38 rs10091527 123.8 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 8 4.72E-05 0.66 rs2812657 62.3 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 10 4.72E-05 1.41 rs2104042 248.4 logistic GE, AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 1 4.73E-05 0.63 rs2104043 248.4 logistic GE, AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 1 4.73E-05 0.63 rs722973 26.7 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 18 4.74E-05 1.43 rs11125629 44.9 logistic low glomerular fitration rate vs. control (follow-up) 2 4.75E-05 1.57 rs4586627 226.9 logistic albuminuria vs. no albuminuria (at entry) 2 4.75E-05 0.76 rs17005685 97.2 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 3 4.75E-05 0.58 rs7082102 102.6 logistic GE, AGE, SEX albuminuria vs. no albuminuria (follow-up) 10 4.76E-05 1.36 rs765 45.0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 15 4.77E-05 0.71 rs645170 34.6 logistic low glomerular fitration rate vs. control (at entry) 19 4.78E-05 1.83 rs4131931 83.6 logistic low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 8 4.78E-05 0.63 rs17134277 108.2 logistic GE, AGE, SEX low creatinine clearance vs. normal creatinine clearance 5 4.79E-05 2.31 rs10223600 24.9 logistic low creatinine clearance vs. normal creatinine clearance 6 4.79E-05 1.58 rs869346 91.7 logistic GE, AGE, SEX microalbuminuria vs. no albuminuria (at entry) 14 4.80E-05 1.64 rs1360411 32.7 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 9 4.81 E-05 1.45 rs629222 239.1 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 1 4.82E-05 1.47 rs1514417 17.9 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 21 4.83E-05 1.60 rs2789417 166.4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 1 4.83E-05 0.53 rs2842754 222.0 logistic low glomerular fitration rate vs. control (at entry) 1 4.83E-05 1.65 rs4663165 245.2 logistic macroalbuminuria vs. no albuminuria (at entry) 2 4.86E-05 1.59 rs16893391 90.1 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 6 4.87E-05 0.43 rs4663165 245.2 logistic AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 2 4.88E-05 1.59 rs9502593 11.5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 6 4.88E-05 1.45 rs16848600 191.7 logistic microalbuminuria vs. no albuminuria (at entry) 1 4.88E-05 0.38 rs982926 130.3 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 5 4.89E-05 1.39 rs2789416 166.4 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 1 4.89E-05 0.53 rs9325744 30.8 logistic microalbuminuria vs. no albuminuria (at entry) 8 4.90E-05 1.51 rs765 45.0 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 15 4.92E-05 0.71

rs 10500411 78 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 16 4 92E-05 1 69 rs11752805 166 6 logistic AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 6 4 93E-05 1 35 rs2926862 156 8 logistic AGE ₁ SEX albuminuria vs no albuminuria (at entry) 5 4 93E-05 1 42 rs1965193 52 7 logistic low glomerular fitration rate vs control (at entry) 12 4 93E-05 1 61 rs8115737 35 2 logistic albuminuria vs no albuminuria (at entry) 20 4 93E-05 040 rs6032948 28 3 logistic low glomerular titration rate vs control (follow-up) 20 4 94E-05 0 62 rs9343494 88 6 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 6 4 94E-05 1 38 rs2502845 191 8 logistic AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 1 4 94E-05 1 37 rs10495829 53 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 4 96E-05 2 23 rs1430373 87 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 4 97E-05 1 41 rs7947110 12 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 4 98E-05 1 62 rs2646261 252 5 logistic microalbuminuria vs no albuminuria (at entry) 2 4 98E-05 1 58 rs6666581 204 5 logistic low creatinine clearance vs normal creatinine clearance 1 4 98E-05 2 43 rs4412353 83 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 4 99E-05 0 63 rs16848600 191 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 5 00E-05 0 38 rs7193007 49 2 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 16 5 02E-05 1 39 rs1523890 4 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 3 5 03E-05 1 49 rs11752805 166 6 logistic microalbuminuria vs no albuminuria (at entry) 6 5 03E-05 1 35 rs454356 95 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 20 5 05E-05 1 58 rs4142863 222 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 5 06E-05 1 61 rs733299 38 3 logistic low creatinine clearance vs normal creatinine clearance 15 5 07E-05 1 43 rs4142863 222 0 logistic macroalbuminuria vs no albuminuria (at entry) 1 5 10E-05 1 61 rs 1764844 239 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 5 10E-05 1 51 rs937527 134 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 5 11 E-05 1 44 rs11595123 11 5 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 10 5 12E-05 0 73 rs4771911 74 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 13 5 14E-05 0 61 rs303765 65 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 5 14E-05 0 72 rs10248275 5 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 5 16E-05 1 97 rs6585304 134 1 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 10 5 16E-05 0 41 rs7193007 49 2 logistic albuminuria vs no albuminuria (at entry) 16 5 17E-05 1 39 rs2066926 28 6 logistic low glomerular fitration rate vs control (at entry) 22 5 20E-05 1 71 rs1472095 36 5 logistic albuminuria vs no albuminuria (follow-up) 4 5 20E-05 1 37 rs7136397 59 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 5 21 E-05 1 45 rs260011 95 5 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 5 21 E-05 2 40 rs17600042 108 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 5 21 E-05 0 45 rs2205895 187 5 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 5 22E-05 1 44 rs41521644 191 7 logistic albuminuria vs no albuminuria (follow-up) 1 5 22E-05 0 50 rs6761875 45 0 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 2 5 22E-05 1 70 rs8115737 35 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 20 5 22E-05 0 40 rs17272796 41 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 3 5 23E-05 1 52

rs4924481 384 logistic low creatinine clearance vs normal creatinine clearance 15 5 25E-05 1 42 rs10749550 102 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 10 5 25E-05 1 33 rs10223600 24 9 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 6 5 26E-05 1 52 rs9354486 82 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 5 26E-05 0 74 rs1379666 88 6 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 6 5 27E-05 1 38 rs4771911 74 4 logistic microalbuminuria vs no albuminuria (at entry) 13 5 28E-05 0 61 rs10000497 43 4 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 4 5 29E-05 0 64 rs4923876 38 4 logistic low creatinine clearance vs normal creatinine clearance 15 5 30E-05 1 42 rs617595 59 8 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 13 5 31 E-05 1 52 rs10248275 5 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 5 31 E-05 1 97 rs312864 105 5 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 17 5 32E-05 1 53 rs9502593 11 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 5 32E-05 1 40 rs2292927 159 2 logistic low glomerular titration rate vs control (follow-up) 8 5 32E-05 1 70 rs937527 134 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 5 33E-05 1 49 rs17115571 127 5 logistic macroalbuminuria vs no albuminuria (at entry) 1 5 35E-05 1 92 rs986866 43 4 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 4 5 35E-05 0 64 rs10105587 101 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 5 36E-05 1 40 rs1452420 38 5 logistic AGE, SEX low glomerular titration rate vs control (at entry) 2 5 38E-05 1 52 rs9300777 86 0 logistic low creatinine clearance vs normal creatinine clearance 13 5 39E-05 1 43 rs1558533 17 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 12 5 39E-05 0 52

OO rs584125 83 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 5 39E-05 1 44 rs7973993 112 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 5 39E-05 1 98 rs4771911 74 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 13 5 40E-05 0 61 rs2732234 114 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 5 41 E-05 0 66 rs17680407 43 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 5 42E-05 0 58 rs4981158 6 5 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 14 5 42E-05 0 64 rs6999595 83 6 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 8 5 42E-05 0 63 rs16848600 191 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 5 43E-05 0 50 rs10071774 68 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 543E-05 0 65 rs11951359 68 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 5 43E-05 0 65 rs11724319 146 0 logistic HBP microalbuminuria vs no albuminuria (at entry) 4 5 43E-05 0 72 rs6444003 196 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 5 43E-05 2 05 rs928579 120 3 logistic low glomerular titration rate vs control (at entry) 10 5 43E-05 0 65 rs7747551 130 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 5 45E-05 0 75 rs4538346 73 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 5 46E-05 0 67 rs1571450 96 6 logistic AGE, SEX low glomerular titration rate vs control (at entry) 9 5 47E-05 1 43 rs9343494 88 6 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 6 5 47E-05 1 38 rs4673727 195 7 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 2 5 48E-05 1 54 rs9283873 39 2 logistic low creatinine clearance vs normal creatinine clearance 6 5 48E-05 1 43 rs6701181 262 8 logistic low glomerular titration rate vs control (at entry) 1 5 48E-05 0 66

rs17029949 137 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 5 48E-05 2 73 rs2391782 127 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 5 49E-05 1 91 rs10471462 68 7 logistic microalbuminuria vs no albuminuria (at entry) 5 5 49E-05 0 65 rs1965193 52 7 logistic low creatinine clearance vs normal creatinine clearance 12 5 50E-05 1 47 rs4580841 82 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 5 50E-05 0 76 rs10989294 102 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 5 51 E-05 0 54 rs3820821 46 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 5 51 E-05 0 43 rs1908329 71 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 5 51 E-05 1 33 rs2000833 87 2 logistic low creatinine clearance vs normal creatinine clearance 18 5 52E-05 0 70 rs12895787 91 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 5 52E-05 1 63 rs7972470 17 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 12 5 52E-05 0 52 rs470455 52 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 5 55E-05 0 69 rs7748736 11 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 5 57E-05 1 41 rs16848171 186 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 5 57E-05 0 54 rs2789416 166 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 5 58E-05 0 53 rs7308867 84 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 5 58E-05 0 71 rs6761875 45 0 logistic low glomerular fitration rate vs control (at entry) 2 5 59E-05 1 58 rs7750426 166 6 logistic microalbuminuria vs no albuminuria (at entry) 6 5 60E-05 0 74 rs1193167 15 5 logistic low creatinine clearance vs normal creatinine clearance 1 5 60E-05 1 42 rs4869544 54 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 5 61 E-05 1 32

VO rs1331484 0 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 5 61 E-05 1 35 rs986866 434 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 4 5 61 E-05 0 69 rs4771911 74 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 13 5 62E-05 0 66 rs12119983 221 9 logistic macroalbuminuria vs no albuminuria (at entry) 1 5 64E-05 1 64 rs7947110 12 7 logistic macroalbuminuria vs no albuminuria (at entry) 11 5 64E-05 1 62 rs2114913 108 9 logistic macroalbuminuria vs no albuminuria (at entry) 12 5 65E-05 2 58 rs4663113 133 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 2 5 66E-05 1 40 rs16825771 226 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 2 5 67E-05 0 74 rs10105587 101 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 8 5 68E-05 1 40 rs12119983 221 9 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 5 68E-05 1 64 rs2404535 133 5 logistic low glomerular fitration rate vs control (follow-up) 2 5 70E-05 1 52 rs6713 88 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 5 70E-05 0 57 rs12966800 87 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 5 71 E-05 0 71 rs2841941 251 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 1 5 75E-05 1 43 rs4771911 74 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 13 5 75E-05 0 61 rs13285280 72 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 9 5 75E-05 0 61 rs17005685 97 2 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 5 76E-05 0 58 rs11130850 81 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 5 76E-05 1 51 rs2926862 156 8 logistic albuminuria vs no albuminuria (at entry) 5 5 77E-05 1 42 rs7750426 166 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 5 77E-05 0 74

rs28490018 114 7 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 5 78E-05 0 62 rs11595123 11 5 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 10 5 78E-05 0 68 rs2391782 127 6 logistic macroalbuminuria vs no albuminuria (at entry) 1 5 79E-05 1 91 rs341395 54 0 logistic GE, AGE, SEX low glomerular Titration rate vs normal glom filtration rate (follow-up) 15 5 79E-05 2 15 rs1379666 88 6 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 6 5 80E-05 1 38 rs 16884604 123 8 logistic low glomerular fitration rate vs control (follow-up) 8 5 83E-05 0 61 rs550523 26 3 logistic GE ₁ AGE, SEX low glomerular fitration rate vs control (at entry) 1 5 84E-05 1 59 rs344708 28 4 logistic low creatinine clearance vs normal creatinine clearance 5 5 85E-05 0 69 rs12973797 58 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 19 5 85E-05 0 67 rs6583607 164 7 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 5 85E-05 0 71 rs11595123 11 5 logistic albuminuria vs no albuminuria (follow-up) 10 5 86E-05 0 73 rs2144825 132 4 logistic AGE ₁ SEX low creatinine clearance vs normal creatinine clearance 14 5 86E-05 1 37 rs4643103 84 9 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 11 5 87E-05 1 38 rs9325744 30 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 8 5 87E-05 1 51 rs632248 83 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 5 87E-05 1 44 rs6810410 77 5 logistic AGE ₁ SEX low glomerular fitration rate vs control (follow-up) 4 5 87E-05 1 50 rs 10863962 221 9 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 5 87E-05 1 62 rs2646261 252 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 5 87E-05 1 58 rs1806753 174 8 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 5 88E-05 0 78 rs7535769 191 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 5 88E-05 1 44

O rs2239961 13 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 22 588E-05 1 47 rs1258246 69 8 logistic low glomerular fitration rate vs control (follow-up) 10 5 88E-05 0 66 rs617595 59 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 5 88E-05 1 52 rs6701181 262 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 1 5 89E-05 0 62 rs12590361 132 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 14 5 90E-05 1 52 rs17334370 109 1 logistic albuminuria vs no albuminuria (at entry) 5 5 90E-05 1 47 rs7027322 27 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 5 90E-05 0 70 rs1558532 17 0 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 12 5 92E-05 0 52 rs7193007 49 2 logistic GE ₁ AGE, SEX microalbuminuria vs no albuminuria (at entry) 16 5 94E-05 1 44 rs10248275 5 3 logistic microalbuminuria vs no albuminuria (at entry) 7 5 95E-05 1 97 rs2412531 38 4 logistic low creatinine clearance vs normal creatinine clearance 15 5 96E-05 1 42 rs8099832 87 2 logistic low creatinine clearance vs normal creatinine clearance 18 5 97E-05 0 70 rs1569175 195 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 2 5 97E-05 1 62 rs1333996 26 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 5 97E-05 1 52 rs1430373 87 2 logistic low creatinine clearance vs normal creatinine clearance 18 5 99E-05 1 41 rs 1356952 134 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 6 01 E-05 1 44 rs2023968 3 1 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs control (follow-up) 7 6 02E-05 0 69 rs6944568 3 1 logistic GE ₁ AGE, SEX low glomerular fitration rate vs control (follow-up) 7 6 02E-05 0 69 rs 1894898 67 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 16 6 03E-05 1 35 rs1333996 26 3 logistic low glomerular fitration rate vs control (follow-up) 9 6 03E-05 1 61

rs4775711 45 O logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 15 6 03E-05 0 71 rs4685409 41 8 logistic AGE, SEX low glomerular titration rate vs control (at entry) 3 6 04E-05 1 49 rs11586374 208 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 6 04E-05 1 45 rs11010400 464 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 10 6 04E-05 2 33 rs11216633 112 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 11 6 06E-05 1 55 rs4712300 33 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 6 07E-05 0 66 rs7842637 114 8 logistic albuminuria vs no albuminuria (at entry) 8 6 07E-05 1 96 rs2646261 252 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 6 08E-05 1 58 rs17680407 43 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 6 09E-05 0 65 rs10122952 112 5 logistic low glomerular titration rate vs control (at entry) 9 6 09E-05 1 88 rs4440442 82 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 6 09E-05 0 75 rs7199114 9 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 6 10E-05 0 67 rs2013004 48 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 9 6 11 E-05 1 37 rs17399090 91 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 6 12E-05 0 69 rs6582 38 4 logistic low creatinine clearance vs normal creatinine clearance 15 6 17E-05 1 42 rs10865331 81 5 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 2 6 18E-05 1 39 rs782113 71 9 logistic MBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 6 18E-05 1 29 rs853956 138 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 10 6 19E-05 1 29 rs1154436 105 5 logistic low glomerular titration rate vs control (follow-up) 4 6 19E-05 0 64 rs2677810 251 3 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 1 6 19E-05 1 42 rs17807662 117 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 9 6 20E-05 045 rs10787476 132 0 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 10 6 22E-05 1 81 rs7301998 59 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 6 22E-05 1 44 rs610414 239 1 logistic AGE, SEX low glomerular titration rate vs control (at entry) 1 6 22E-05 1 48 rs17042290 84 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 6 22E-05 0 72 rs4985702 44 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 17 6 23E-05 0 69 rs4925109 45 0 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 17 6 24E-05 1 39 rs9540649 50 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 13 6 24E-05 0 67 rs8115737 35 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 20 6 26E-05 0 30 rs7281608 17 9 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 21 6 27E-05 1 57 rs17134275 108 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 6 27E-05 2 18 rs7029315 102 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 9 6 27E-05 1 57 rs6427833 214 2 logistic low glomerular titration rate vs control (at entry) 1 6 28E-05 1 67 rs1545741 93 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 6 28E-05 2 33 rs10803476 31 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 6 29E-05 0 69 rs16889712 124 9 logistic albuminuria vs no albuminuria (at entry) 8 6 30E-05 1 50 rs6715897 232 3 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 2 6 30E-05 0 57 rs10496309 106 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 2 6 31 E-05 0 68 rs10749578 102 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 10 6 31 E-05 1 35 rs17171382 141 4 logistic low glomerular titration rate vs control (at entry) 5 6 32E-05 1 80

rs4266861 2087 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 6 32E-05 1 45 rs2789416 1664 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 6 32E-05 0 53 rs3856447 192 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 2 6 32E-05 0 71 rs17600042 108 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 7 6 33E-05 0 50 rs7027322 27 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 6 33E-05 0 68 rs10970744 56 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 6 33E-05 1 39 rs10471462 68 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 6 35E-05 0 65 rs6675190 67 5 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 1 6 35E-05 1 30 rs6429453 275 7 logistic AGE, SEX low glomerular Titration rate vs control (at entry) 1 6 37E-05 1 98 rs17334370 109 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 6 39E-05 1 47 rs10495444 262 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 6 39E-05 1 31 rs4597881 77 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 6 40E-05 1 52 rs355460 77 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 6 40E-05 1 52 rs1331484 0 9 logistic albuminuria vs no albuminuria (at entry) 6 6 41 E-05 1 35 rs535620 65 3 logistic HBP ₁ diabetes duration microalbuminuria vs no albuminuria (at entry) 1 6 43E-05 0 81 rs10091527 123 8 logistic low glomerular fitration rate vs control (follow-up) 8 6 43E-05 0 60 rs4235846 98 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 6 43E-05 1 50 rs2841941 251 3 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 1 6 44E-05 1 48 rs1402337 134 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 6 45E-05 1 44 rs2508492 116 1 logistic macroalbuminuria vs no albuminuria (at entry) 11 6 46E-05 3 37

K) rs2844032 60 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 6 47E-05 0 59 rs341395 54 0 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 15 6 48E-05 2 15 rs303765 65 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 12 6 48E-05 0 72 rs17171382 141 4 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 5 6 48E-05 2 15 rs17078168 8 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 8 6 49E-05 0 57 rs16848600 191 7 logistic albuminuria vs no albuminuria (follow-up) 1 6 49E-05 0 50 rs17078168 8 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 8 6 49E-05 0 57 rs9697134 78 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 6 49E-05 2 06 rs682970 29 6 logistic microalbuminuria vs no albuminuria (at entry) 10 6 50E-05 2 53 rs10495444 262 1 logistic albuminuria vs no albuminuria (follow-up) 1 6 50E-05 1 31 rs7161611 6 5 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 14 6 51 E-05 0 65 rs17411195 105 9 logistic AGE, SEX low glomerular titration rate vs control (at entry) 1 6 51 E-05 0 73 rs7559347 119 5 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 2 6 52E-05 1 38 rs12545592 83 6 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 8 6 52E-05 0 63 rs2292927 159 2 logistic low glomerular titration rate vs control (at entry) 8 6 53E-05 1 65 rs17221260 0 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 10 6 55E-05 0 76 rs7646681 119 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 6 55E-05 1 72 rs10179954 69 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 2 6 56E-05 1 30 rs2419533 131 2 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 4 6 56E-05 1 67 rs17095305 982 logistic macroalbuminuria vs no albuminuria (at entry) 11 6 57E-05 3 95

rs10897992 72 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 6 58E-05 0 64 rs10501407 72 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 6 58E-05 0 64 rs354391 81 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 6 58E-05 0 75 rs7808966 180 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 6 59E-05 0 74 rs9646596 76 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 6 59E-05 0 39 rs4923876 38 4 logistic low glomerular fitration rate vs control (follow-up) 15 6 59E-05 1 53 rs4924481 38 4 logistic low glomerular fitration rate vs control (follow-up) 15 6 59E-05 1 53 rs2412524 38 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 15 6 60E-05 1 45 rs12545592 83 6 logistic low creatinine clearance vs normal creatinine clearance 8 6 61 E-05 0 61 rs17078168 8 6 logistic albuminuria vs no albuminuria (at entry) 8 6 62E-05 0 57 rs4771911 74 4 logistic albuminuria vs no albuminuria (follow-up) 13 6 64E-05 0 66 rs7947110 12 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 6 66E-05 1 62 rs10238177 90 6 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 7 6 67E-05 1 34 rs4771911 74 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 13 6 68E-05 0 66 rs11010400 46 4 logistic microalbuminuria vs no albuminuria (at entry) 10 6 68E-05 2 33 rs12258211 81 8 logistic GE ₁ AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 10 6 69E-05 1 59 rs2396328 226 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 6 70E-05 0 68 rs16884604 123 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 6 71 E-05 0 67 rs10978601 112 5 logistic low glomerular fitration rate vs control (at entry) 9 6 72E-05 1 87 rs10956801 102 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 8 6 73E-05 2 14 rs2964003 156 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 6 75E-05 1 42 rs1351887 105 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 6 76E-05 0 50 rs10904339 11 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 10 6 77E-05 0 67 rs2412531 38 4 logistic low glomerular fitration rate vs control (follow-up) 15 6 78E-05 1 52 rs17005685 97 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 6 78E-05 0 58 rs11070285 38 5 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 15 6 79E-05 1 41 rs7183000 115 0 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 15 6 79E-05 1 45 rs448666 60 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 6 80E-05 0 54 rs9300777 86 0 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 13 6 80E-05 1 43 rs17670198 80 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 6 80E-05 1 35 rs930056 136 7 logistic macroalbuminuria vs no albuminuria (at entry) 5 6 81 E-05 0 54 rs13413437 119 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 6 84E-05 1 38 rs10749550 102 6 logistic albuminuria vs no albuminuria (follow-up) 10 6 84E-05 1 33 rs16825731 186 7 logistic GE ₁ AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 6 85E-05 0 54 rs10897976 84 9 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 11 6 85E-05 1 49 rs9424612 248 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 6 86E-05 0 64 rs28490018 114 7 logistic low glomerular fitration rate vs control (follow-up) 14 6 87E-05 0 55 rs10865331 81 5 logistic low glomerular fitration rate vs control (at entry) 2 6 88E-05 1 52 rs1413618 120 3 logistic low glomerular fitration rate vs control (at entry) 10 6 88E-05 0 65 rs6472341 83 6 logistic low creatinine clearance vs normal creatinine clearance 8 6 89E-05 0 61

rs9969560 83 6 logistic low creatinine clearance vs normal creatinine clearance 8 6 89E-05 0 61 rs10871383 104 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 6 90E-05 1 38 rs2732234 114 5 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 18 6 91 E-05 0 72 rs10500411 78 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 16 6 91 E-05 1 69 rs10233697 66 3 logistic microalbuminuria vs no albuminuria (at entry) 7 6 91 E-05 1 41 rs719213 123 8 logistic low glomerular fitration rate vs control (at entry) 8 6 93E-05 0 58 rs4424038 156 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 6 94E-05 1 38 rs10193792 157 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 6 94E-05 0 66 rs162079 69 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 20 6 94E-05 1 39 rs682970 29 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 10 6 94E-05 2 53 rs158687 97 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 6 95E-05 0 72 rs1322051 49 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 6 96E-05 0 47 rs41521644 191 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 6 99E-05 0 44 rs1558533 17 0 logistic albuminuria vs no albuminuria (follow-up) 12 7 00E-05 0 52 rs1825443 107 4 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 8 7 02E-05 0 69 rs7842637 114 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 8 7 03E-05 1 96 rs5003737 122 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 9 7 03E-05 0 71 rs9969560 83 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 7 03E-05 0 63 rs6472341 83 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 7 03E-05 0 63 rs1334237 41 4 logistic low glomerular fitration rate vs control (at entry) 13 7 03E-05 1 53 rs10492295 94 1 logistic macroalbuminuria vs no albuminuria (at entry) 12 7 03E-05 3 99 rs171500 33 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 20 7 04E-05 1 30 rs7765427 91 2 logistic low glomerular fitration rate vs control (follow-up) 6 7 05E-05 1 69 rs2789417 166 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 7 05E-05 0 53 rs1530104 131 7 logistic low creatinine clearance vs normal creatinine clearance 2 7 06E-05 0 69 rs7029315 102 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 9 7 06E-05 1 57 rs16880395 43 3 logistic low glomerular fitration rate vs control (follow-up) 4 7 07E-05 0 61 rs11735854 43 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 7 07E-05 0 75 rs10498537 89 1 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 14 7 08E-05 0 72 rs12590361 132 2 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 14 7 09E-05 1 52 rs4736185 158 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 8 7 10E-05 0 69 rs782108 71 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 7 12E-05 1 30 rs10816423 112 5 logistic low glomerular fitration rate vs control (at entry) 9 7 13E-05 1 86 rs4131931 83 6 logistic low creatinine clearance vs normal creatinine clearance 8 7 14E-05 0 61 rs4334629 41 8 logistic AGE ₁ SEX low glomerular fitration rate vs control (at entry) 3 7 15E-05 0 66 rs12543318 101 9 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 8 7 15E-05 0 61 rs7243021 68 2 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 7 15E-05 0 72 rs6472346 83 6 logistic low creatinine clearance vs normal creatinine clearance 8 7 17E-05 0 53 rs11829500 59 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 7 18E-05 0 67 rs7972470 17 0 logistic albuminuria vs no albuminuria (follow-up) 12 7 18E-05 0 52

rs11648875 104 7 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 16 7 19E-05 1 71 rs10915955 242 2 logistic low creatinine clearance vs normal creatinine clearance 1 7 19E-05 1 53 rs6488711 31 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 7 20E-05 0 68 rs12962651 87 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 7 22E-05 0 71 rs1143694 102 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 10 7 22E-05 1 33 rs1558533 17 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 7 23E-05 0 52 rs584125 83 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 7 23E-05 1 44 rs10865331 81 5 logistic low glomerular Titration rate vs normal glom filtration rate (follow-up) 2 7 25E-05 1 39 rs4422395 81 4 logistic microalbuminuria vs no albuminuria (at entry) 4 7 26E-05 1 45 rs10922204 204 5 logistic low creatinine clearance vs normal creatinine clearance 1 7 26E-05 2 37 rs12966800 87 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 7 26E-05 0 71 rs4406411 101 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 7 27E-05 1 39 rs610494 69 9 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance- 20 7 27E-05 0 75 rs7557611 164 3 logistic albuminuria vs no albuminuria (at entry) 2 7 29E-05 1 33 rs438163 105 5 logistic low glomerular Titration rate vs normal glom filtration rate (follow-up) 17 7 30E-05 1 52 rs7973993 112 5 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 12 7 32E-05 2 17 rs11724319 146 0 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 4 7 33E-05 0 72 rs246277 130 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 7 34E-05 1 62 rs7746351 166 6 logistic microalbuminuria vs no albuminuria (at entry) 6 7 37E-05 1 35 rs7201164 81 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 16 7 38E-05 1 27 rs16889712 124 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 8 7 38E-05 1 50 rs7972470 17 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 7 40E-05 0 52 rs7668533 77 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 7 40E-05 1 52 rs3112857 198 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 4 7 40E-05 1 49 rs4412353 83 6 logistic low creatinine clearance vs normal creatinine clearance 8 7 41 E-05 0 61 rs11735854 43 3 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 7 41 E-05 0 64 rs928579 120 3 logistic low glomerular fitration rate vs control (follow-up) 10 7 42E-05 0 65 rs9394187 46 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 6 7 42E-05 0 73 rs11233277 72 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 7 43E-05 0 67 rs10875745 63 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 7 44E-05 1 32 rs2077663 87 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 16 7 45E-05 1 49 rs16884604 123 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 8 745E-05 0 67 rs4235846 98 9 logistic low glomerular fitration rate vs control (follow-up) 6 7 45E-05 1 69 rs17725296 42 6 logistic macroalbuminuria vs no albuminuria (at entry) 2 7 45E-05 0 62 rs9843093 119 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 7 47E-05 1 72 rs6508259 50 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 18 7 47E-05 1 37 rs2502845 191 8 logistic albuminuria vs no albuminuria (at entry) 1 7 47E-05 1 32 rs4128841 251 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 1 7 47E-05 1 48 rs11848645 37 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 7 49E-05 1 36 rs162079 69 6 logistic albuminuria vs no albuminuria (follow-up) 20 7 49E-05 1 39

rs1430382 872 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 749E-05 070 rs10177595 450 logistic low glomerular titration rate vs control (follow-up) 2 749E-05 155 rs1872292 145 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 4 750E-05 064 rs930056 136 7 logistic AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 5 751 E-05 054 rs7746351 166 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 752E-05 135 rs2282367 102 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 10 754E-05 132 rs17725296 42 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 754E-05 062 rs1356952 134 5 logistic albuminuria vs no albuminuria (at entry) 12 755E-05 139 rs5003737 122 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 755E-05 071 rs661609 83 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 756E-05 143 rs8099832 87 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 756E-05 070 rs9325744 30 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 8 757E-05 151 rs7019068 117 2 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 757E-05 072 rs2812657 62 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 10 759E-05 141 rs791743 191 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 759E-05 141 rs2000833 87 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 761E-05 070 rs10897992 72 9 logistic albuminuria vs no albuminuria (at entry) 11 762E-05 064 rs10501407 72 9 logistic albuminuria vs no albuminuria (at entry) 11 762E-05 064 rs2046535 198 3 logistic low glomerular fitration rate vs control (follow-up) 4 763E-05 153 rs7029315 102 5 logistic albuminuria vs no albuminuria (at entry) 9 763E-05 157 rs10233697 66 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 764E-05 141 rs12599351 124 5 logistic albuminuria vs no albuminuria (follow-up) 16 764E-05 076 rs17399090 91 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 9 764E-05 069 rs7651436 68 3 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 764E-05 235 rs4406411 101 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 8 765E-05 139 rs2023968 3 1 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 7 765E-05 071 rs1558532 17 0 logistic albuminuria vs no albuminuria (follow-up) 12 765E-05 052 rs4924481 38 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 15 766E-05 153 rs4923876 38 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 15 766E-05 153 rs4334629 41 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 3 766E-05 066 rs1872292 145 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 4 767E-05 064 rs4631962 9 2 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 767E-05 062 rs11054878 17 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 12 769E-05 053 rs7985116 86 0 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 13 769E-05 069 rs9697134 78 3 logistic macroalbuminuria vs no albuminuria (at entry) 9 769E-05 206 rs1402337 134 5 logistic albuminuria vs no albuminuria (at entry) 12 771E-05 139 rs6701181 262 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 1 771E-05 062 rs17807662 117 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 772E-05 045 rs9686988 136 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 773E-05 059 rs11707973 152 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 773E-05 068

rs1461237 156 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 7 76E-05 1 39 rs4334629 41 8 logistic low glomerular titration rate vs control (at entry) 3 7 78E-05 0 66 rs17670198 804 logistic microalbuminuria vs no albuminuria (at entry) 3 7 78E-05 1 35 rs2732234 114 5 logistic albuminuria vs no albuminuria (follow-up) 18 7 79E-05 0 72 rs7027322 27 9 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 9 7 79E-05 0 70 rs1571450 96 6 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 9 7 80E-05 1 43 rs4334629 41 8 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 3 7 80E-05 0 64 rs4685409 41 8 logistic low glomerular titration rate vs control (follow-up) 3 7 80E-05 1 51 rs661609 83 8 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 18 7 81 E-05 1 43 rs10816424 112 5 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 9 7 81 E-05 1 59 rs1558532 17 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 7 81 E-05 0 52 rs13413437 119 5 logistic low creatinine clearance vs normal creatinine clearance 2 7 84E-05 1 41 rs9697134 78 3 logistic GE, AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 9 7 85E-05 2 06 rs9498737 103 2 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 6 7 85E-05 1 33 rs2481628 191 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 7 85E-05 1 41 rs11694629 131 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 7 85E-05 0 45 rs259994 95 6 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 20 7 86E-05 2 22 rs3858637 65 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 7 87E-05 1 37 rs4728666 98 0 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 7 92E-05 1 28 rs10223600 24 9 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 6 7 93E-05 1 52

K)

-J rs8056052 67 3 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 7 93E-05 1 46 rs7651436 68 3 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 3 7 94E-05 2 35 rs10858809 94 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 7 95E-05 1 71 rs7193007 49 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 16 7 96E-05 1 41 rs2677810 251 3 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 1 7 96E-05 1 47 rs6999595 83 6 logistic low creatinine clearance vs normal creatinine clearance 8 7 96E-05 0 61 rs7243021 68 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 7 97E-05 072 rs10465473 248 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 7 97E-05 0 59 rs17334370 109 1 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 5 7 98E-05 0 60 rs7748736 11 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 7 98E-05 1 46 rs12599351 124 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 16 7 98E-05 0 76 rs1333996 26 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 7 99E-05 1 52 rs4341081 151 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 7 99E-05 0 71 rs8044632 67 2 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 7 99E-05 1 33 rs17568979 72 7 logistic low glomerular titration rate vs control (at entry) 2 8 00E-05 2 13 rs10242865 111 8 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 7 8 01 E-05 1 32 rs10749578 102 6 logistic albuminuria vs no albuminuria (follow-up) 10 8 02E-05 1 35 rs4132236 82 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 8 03E-05 0 76 rs6676401 244 5 logistic microalbuminuria vs no albuminuria (at entry) 1 8 04E-05 2 22 rs1530104 131 7 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 2 8 07E-05 0 71

rs12826155 71.9 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 12 8.08E-05 1.24 rs41521644 191.7 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 1 8.08E-05 0.44 rs12911453 70.1 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 15 8.11E-05 1.42 rs11829500 59.4 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 12 8.11E-05 0.67 rs10000497 43.4 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 4 8.11E-05 0.70 rs4321205 38.9 logistic low glomerular fitration rate vs. control (at entry) 16 8.11E-05 0.66 rs4280249 38.9 logistic low glomerular fitration rate vs. control (at entry) 16 8.11E-05 0.66 rs4369676 38.9 logistic low glomerular fitration rate vs. control (at entry) 16 8.11E-05 0.66 rs9920389 102.0 logistic GE, AGE, SEX low glomerular fitration rate vs. control (follow-up) 15 8.12E-05 0.77 rs4883520 168.2 logistic GE, AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 12 8.12E-05 0.58 rs2023968 3.1 logistic AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 7 8.12E-05 0.71 rs9540649 50.4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 13 8.14E-05 0.67 rs6737578 5.7 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 2 8.15E-05 2.52 rs13249327 83.6 logistic low creatinine clearance vs. normal creatinine clearance 8 8.15E-05 0.61 rs6831744 145.0 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 4 8.16E-05 0.64 rs2873929 77.5 logistic GE ₁ AGE, SEX low glomerular fitration rate vs. control (follow-up) 4 8.16E-05 1.51 rs7655850 77.5 logistic GE, AGE, SEX low glomerular fitration rate vs. control (follow-up) 4 8.16E-05 1.51 rs10863962 221.9 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs. no albuminuria (at entry) 1 8.17E-05 1.62 rs11054588 17.0 logistic AGE, SEX albuminuria vs. no albuminuria (follow-up) 12 8.17E-05 0.53 rs782103 71.9 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 12 8.18E-05 1.28

OO rs16851268 216.8 logistic HBP microalbuminuria vs. no albuminuria (at entry) 1 8.19E-05 0.67 rs2013004 48.0 logistic albuminuria vs. no albuminuria (at entry) 9 8.20E-05 1.37 rs4643103 84.9 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 11 8.20E-05 1.36 rs17095305 98.2 logistic AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 11 8.21 E-05 3.95 rs11233277 72.9 logistic GE, AGE, SEX albuminuria vs. no albuminuria (at entry) 11 8.22E-05 0.67 rs2964003 156.8 logistic albuminuria vs. no albuminuria (at entry) 5 8.22E-05 1.42 rs733299 38.3 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 15 8.24E-05 1.55 rs12616972 238.2 logistic GE, AGE, SEX low glomerular fitration rate vs. control (follow-up) 2 8.24E-05 1.44 rs11233277 72.9 logistic albuminuria vs. no albuminuria (at entry) 11 8.26E-05 0.67 rs12045707 222.0 logistic GE, AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 1 8.26E-05 1.62 rs6944568 3.1 logistic AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 7 8.27E-05 0.71 rs4685409 41.8 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 3 8.27E-05 1.49 rs6807126 190.0 logistic HBP microalbuminuria vs. no albuminuria (at entry) 3 8.27E-05 0.68 rs10863962 221.9 logistic macroalbuminuria vs. no albuminuria (at entry) 1 8.29E-05 1.62 rs11204592 288.5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 1 8.30E-05 1.47 rs791743 191.8 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 1 8.30E-05 1.41 rs869346 91.7 logistic albuminuria vs. no albuminuria (at entry) 14 8.31 E-05 1.55 rs2194391 72.6 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 2 8.31 E-05 1.69 rs16889748 124.9 logistic albuminuria vs. no albuminuria (at entry) 8 8.33E-05 1.49 rs1563734 94.7 logistic GE, AGE, SEX albuminuria vs. no albuminuria (at entry) 18 8.34E-05 0.47

rs7244113 94 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 18 8 34E-05 0 47 rs17070627 94 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 18 8 34E-05 0 47 rs 10503076 94 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 18 8 34E-05 0 47 rs6944568 3 1 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 7 8 34E-05 0 71 rs7834887 138 4 logistic AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 8 8 34E-05 2 11 rs7764326 164 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 8 34E-05 1 40 rs2862907 10 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 13 8 35E-05 1 61 rs194781 74 2 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 14 8 35E-05 1 53 rs6780191 41 8 logistic low glomerular fitration rate vs control (follow-up) 3 8 36E-05 1 51 rs7203172 48 8 logistic albuminuria vs no albuminuria (at entry) 16 8 37E-05 0 63 rs13240269 66 4 logistic microalbuminuria vs no albuminuria (at entry) 7 8 37E-05 1 40 rs17801910 78 0 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 8 38E-05 1 97 rs4955814 73 7 logistic microalbuminuria vs no albuminuria (at entry) 3 8 38E-05 1 35 rs11688740 80 0 logistic albuminuria vs no albuminuria (at entry) 2 8 40E-05 1 37 rs289450 108 9 logistic low glomerular fitration rate vs control (follow-up) 15 8 41 E-05 044 rs7834887 138 4 logistic macroalbuminuria vs no albuminuria (at entry) 8 8 41 E-05 2 11 rs765188 52 3 logistic albuminuria vs no albuminuria (follow-up) 3 8 41 E-05 0 76 rs7557611 164 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 8 42E-05 1 33 rs16901597 138 2 logistic low glomerular fitration rate vs control (at entry) 8 8 44E-05 4 26 rs17006815 47 4 logistic albuminuria vs no albuminuria (at entry) 2 8 45E-05 1 69

VO rs10070326 8 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 5 846E-05 368 rs11688740 80 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 8 46E-05 1 37 rs158688 97 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 8 47E-05 0 72 rs11609178 94 1 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 8 47E-05 1 96 rs12956604 109 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 8 48E-05 1 41 rs4334629 41 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 3 8 48E-05 0 64 rs10238177 90 6 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 7 8 48E-05 1 34 rs421853 44 9 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 15 8 48E-05 1 65 rs17006815 47 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 8 49E-05 1 69 rs1860192 11 7 logistic microalbuminuria vs no albuminuria (at entry) 19 8 49E-05 1 42 rs6472345 83 6 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 8 8 52E-05 0 64 rs10978606 112 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 8 52E-05 1 58 rs3813582 104 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 8 53E-05 1 41 rs194781 74 2 logistic microalbuminuria or macroalbuminuria vs control (at entry) 14 8 54E-05 1 53 rs1241940 91 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 8 56E-05 1 59 rs448666 60 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 8 57E-05 0 54 rs16901596 138 2 logistic low creatinine clearance vs normal creatinine clearance 8 8 57E-05 2 54 rs4936167 141 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 8 57E-05 048 rs344708 28 4 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 5 8 58E-05 0 67 rs986866 43 4 logistic low glomerular fitration rate vs control (follow-up) 4 8 59E-05 0 64

rs4128841 251 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 8 59E-05 1 44 rs3820821 46 6 logistic microalbuminuria vs no albuminuria (at entry) 2 8 60E-05 0 43 rs934609 45 1 logistic low glomerular fitration rate vs control (follow-up) 2 8 60E-05 1 54 rs610414 239 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 1 8 61 E-05 1 46 rs17654227 66 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 8 62E-05 1 40 rs2194391 72 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 8 63E-05 1 69 rs882869 264 9 logistic AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 1 8 65E-05 1 56 rs1860192 11 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 19 8 65E-05 1 42 rs4771911 74 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 13 8 67E-05 0 61 rs10511345 130 0 logistic albuminuria vs no albuminuria (at entry) 3 8 68E-05 1 32 rs7621243 42 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 8 69E-05 0 62 rs750576 206 5 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 8 72E-05 0 68 rs10223600 24 9 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 6 8 72E-05 1 52 rs11624722 51 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 8 73E-05 0 68 rs869346 91 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 14 8 73E-05 1 55 rs807525 41 8 logistic albuminuria vs no albuminuria (follow-up) 6 8 75E-05 0 64 rs7199114 9 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 8 75E-05 0 68 rs2220521 172 8 logistic macroalbuminuria vs no albuminuria (at entry) 3 8 75E-05 0 59 rs2936535 8 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 8 8 76E-05 0 68 rs355483 77 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 8 78E-05 1 51

O rs9505118 11 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 8 79E-05 1 32 rs2502845 191 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 8 80E-05 1 32 rs10000497 43 4 logistic low glomerular fitration rate vs control (follow-up) 4 8 80E-05 0 64 rs1986877 55 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 7 8 81 E-05 0 74 rs11810706 191 8 logistic albuminuria vs no albuminuria (at entry) 1 8 81 E-05 1 32 rs1549840 76 6 logistic low creatinine clearance vs normal creatinine clearance 2 8 82E-05 1 42 rs16898990 115 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 8 83E-05 0 66 rs2057028 604 logistic low creatinine clearance vs normal creatinine clearance 20 8 85E-05 1 65 rs4940497 87 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 8 85E-05 0 72 rs6761875 45 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 2 8 86E-05 1 70 rs9354486 82 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 8 87E-05 0 74 rs1416641 89 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 6 8 88E-05 0 55 rs10897992 72 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 8 88E-05 0 64 rs10501407 72 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 8 88E-05 0 64 rs4333309 130 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 8 89E-05 1 52 rs4925109 45 0 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 17 8 91 E-05 1 39 rs4235846 98 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 8 91 E-05 1 50 rs41454946 22 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 8 92E-05 0 60 rs7981243 18 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 13 8 92E-05 0 67 rs4394376 83 6 logistic low creatinine clearance vs normal creatinine clearance 8 8 93E-05 0 61

rs1413618 120 3 logistic low glomerular fitration rate vs control (follow-up) 10 8 94E-05 0 66 rs7578292 145 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 8 96E-05 1 63 rs7977693 96 0 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (at entry) 12 8 96E-05 1 39 rs6780191 41 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 3 8 97E-05 1 50 rs1430377 87 2 logistic low creatinine clearance vs normal creatinine clearance 18 8 97E-05 0 71 rs3917768 187 5 logistic low glomerular fitration rate vs control (at entry) 1 8 97E-05 1 52 rs4341081 151 1 logistic microalbuminuria or microalbuminuria vs control (follow-up) 7 8 97E-05 0 71 rs191606 191 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 8 98E-05 1 43 rs4236836 107 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 8 98E-05 1 31 rs13240269 664 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 8 98E-05 1 40 rs6018685 68 5 logistic microalbuminuria or macroalbuminuπa vs control (follow-up) 20 8 99E-05 1 41 rs1966908 103 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 9 00E-05 0 62 rs16838911 159 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 2 9 00E-05 1 89 rs16965001 81 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 16 9 00E-05 1 29 rs10897976 84 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 11 9 00E-05 1 49 rs16838911 159 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 2 9 02E-05 1 89 rs4538346 73 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 3 9 02E-05 0 67 rs704829 191 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 9 03E-05 1 40 rs11707973 152 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 3 9 03E-05 0 68 rs1894898 67 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 16 9 04E-05 1 35 rs10040971 130 1 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 9 06E-05 1 53 rs9498737 103 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 6 9 07E-05 1 33 rs28891 130 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 9 08E-05 1 62 rs2046535 198 3 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 9 08E-05 1 37 rs7136397 59 4 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 12 9 09E-05 1 50 rs2936534 8 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 8 9 09E-05 0 68 rs9293123 37 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 909E-05 1 47 rs7188142 80 2 logistic low glomerular fitration rate vs control (at entry) 16 9 10E-05 1 54 rs2936534 8 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 9 10E-05 0 68 rs765 45 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 15 9 12E-05 0 77 rs726820 106 1 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 9 13E-05 1 41 rs2566349 93 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 3 9 13E-05 1 35 rs9502593 11 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 9 13E-05 1 45 rs10787476 132 0 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 10 9 13E-05 1 81 rs1999717 18 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 13 9 14E-05 0 67 rs6861743 108 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 9 14E-05 2 35 rs937527 134 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 9 14E-05 1 49 rs6780191 41 8 logistic low glomerular fitration rate vs control (at entry) 3 9 15E-05 1 50 rs1764844 239 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 1 9 15E-05 1 48 rs765188 52 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 3 9 16E-05 0 76

rs2481628 191 8 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 1 9 16E-05 1 41 rs9293123 37 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 9 17E-05 1 47 rs9323200 53 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 14 9 17E-05 1 35 rs2190963 232 logistic albuminuria vs no albuminuria (at entry) 17 9 18E-05 2 14 rs2267889 120 7 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 7 9 18E-05 0 39 rs6658141 288 4 logistic low glomerular fitration rate vs control (follow-up) 1 9 18E-05 1 80 rs6760957 119 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 9 19E-05 1 37 rs9287229 262 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 9 19E-05 1 30 rs10817737 103 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 9 9 20E-05 0 73 rs2412531 38 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 15 9 21 E-05 1 52 rs550523 26 3 logistic low glomerular fitration rate vs control (at entry) 1 9 23E-05 1 59 rs3909788 125 5 logistic low glomerular fitration rate vs control (follow-up) 12 9 25E-05 0 62 rs7808966 180 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 9 25E-05 0 74 rs1344311 45 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 15 9 25E-05 0 72 rs12956604 109 3 logistic low creatinine clearance vs normal creatinine clearance 18 9 27E-05 1 41 .rs1966909 103 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 9 27E-05 0 62 rs9287229 262 1 logistic albuminuria vs no albuminuria (follow-up) 1 9 28E-05 1 30 rs807525 41 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 9 28E-05 0 64 rs7695033 95 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 9 29E-05 2 24 rs17399090 91 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 9 9 31 E-05 0 74 rs10234057 66 5 logistic microalbuminuria vs no albuminuria (at entry) 7 9 32E-05 1 40 rs1013685 19 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 9 33E-05 0 76 rs6831744 145 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 4 9 33E-05 0 64 rs10749550 102 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 10 9 34E-05 1 33 rs7680113 205 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 4 9 35E-05 1 25 rs2833998 30 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 21 9 35E-05 1 34 rs879574 4 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 22 9 36E-05 1 71 rs10792617 84 9 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 11 9 37E-05 1 36 rs16848600 191 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 9 38E-05 0 45 rs4422395 81 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 4 9 39E-05 1 45 rs17343615 38 0 logistic low glomerular fitration rate vs control (at entry) 5 9 39E-05 1 76 rs10489185 187 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 9 41 E-05 1 40 rs4790200 10 9 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 17 9 43E-05 2 17 rs17648942 153 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 8 9 44E-05 0 77 rs11070285 38 5 logistic low creatinine clearance vs normal creatinine clearance 15 9 45E-05 1 41 rs1143694 102 6 logistic albuminuria vs no albuminuria (follow-up) 10 9 46E-05 1 33 rs11125629 44 9 logistic low glomerular fitration rate vs control (at entry) 2 9 47E-05 1 52 rs733299 38 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 15 9 47E-05 1 43 rs10511345 130 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 9 48E-05 1 32 rs1514417 17 9 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 21 9 49E-05 1 64

rs12485415 42 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 3 9 51 E-05 2 05 rs4685409 41 8 logistic low glomerular fitration rate vs control (at entry) 3 9 51 E-05 1 49 rs1356952 134 5 logistic AGE ₁ SEX albuminuria vs no albuminuria (at entry) 12 9 53E-05 1 39 rs1441511 32 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 11 9 53E-05 0 72 rs2194390 72 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 2 9 53E-05 1 68 rs7136397 59 4 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 9 54E-05 1 45 rs13240269 66 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 9 54E-05 1 40 rs1229979 105 5 logistic low glomerular fitration rate vs control (follow-up) 4 9 55E-05 0 65 rs12775879 132 0 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 10 9 58E-05 1 77 rs1241940 91 6 logistic microalbuminuria vs no albuminuria (at entry) 14 9 59E-05 1 59 rs4571397 66 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 9 60E-05 1 38 rs32058 159 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 9 62E-05 1 32 rs11694629 131 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 2 9 62E-05 0 45 rs7193007 49 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 16 9 64E-05 1 39 rs41530345 66 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 9 9 65E-05 1 57 rs4367362 82 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 9 66E-05 0 75 rs2194390 72 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 9 66E-05 1 68 rs9383240 32 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 9 67E-05 1 29 rs9505117 11 5 logistic albuminuria vs no albuminuria (follow-up) 6 9 68E-05 1 32 rs6666581 204 5 logistic low glomerular fitration rate vs control (at entry) 1 9 68E-05 3 37 rs16830489 204 4 logistic low glomerular fitration rate vs control (at entry) 1 9 68E-05 3 37 rs4142863 222 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 9 68E-05 1 61 rs7027322 27 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 9 9 69E-05 0 68 rs1002169 3 0 logistic macroalbuminuria vs no albuminuria (at entry) 7 9 69E-05 0 53 rs12595945 65 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 9 70E-05 0 68 rs765 45 0 logistic albuminuria vs no albuminuria (at entry) 15 9 73E-05 0 77 rs16880395 43 3 logistic albuminuria vs no albuminuria (at entry) 4 9 73E-05 0 73 rs12604327 87 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 9 74E-05 0 72 rs2026692 44 4 logistic macroalbuminuria vs no albuminuria (at entry) 13 9 75E-05 1 57 rs1402337 134 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 12 9 75E-05 1 39 rs1002169 3 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 9 76E-05 0 53 rs7808966 180 5 logistic microalbuminuria vs no albuminuria (at entry) 7 9 76E-05 0 74 rs168965 74 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 14 9 79E-05 1 52 rs2566349 93 4 logistic albuminuria vs no albuminuria (follow-up) 3 9 79E-05 1 35 rs11185172 140 1 logistic AGE ₁ SEX albuminuria vs no albuminuria (at entry) 1 9 80E-05 1 30 rs16889748 124 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 8 9 82E-05 1 49 rs2912020 8 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 8 9 82E-05 0 68 rs11054878 17 1 logistic albuminuria vs no albuminuria (follow-up) 12 9 83E-05 0 53 rs1327210 50 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 13 9 83E-05 0 68 rs4496808 32 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 9 85E-05 1 29

rs2936535 8 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 985E-05 068 rs10511345 130 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 3 987E-05 132 rs7195806 124 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 987E-05 069 rs11054878 17 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 988E-05 053 rs7233192 87 3 logistic low creatinine clearance vs normal creatinine clearance 18 990E-05 071 rs8056052 67 3 logistic GE, AGE, SEX low glomerular Titration rate vs control (at entry) 16 990E-05 146 rs424301 21 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 990E-05 135 rs6578592 10 2 logistic microalbuminuria vs no albuminuria (at entry) 11 990E-05 070 rs2445290 9 7 logistic albuminuria vs no albuminuria (follow-up) 11 991E-05 147 rs11810706 191 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 992E-05 132 rs1356704 42 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 992E-05 063 rs10234057 66 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 994E-05 140 rs9924993 27 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 16 995E-05 072 rs11586374 208 7 logistic albuminuria vs no albuminuria (follow-up) 1 996E-05 145 rs2146162 164 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 996E-05 139 rs2035219 29 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 998E-05 053 rs16838911 159 0 logistic albuminuria vs no albuminuria (follow-up) 2 00001003 189 rs2282367 102 6 logistic albuminuria vs no albuminuria (follow-up) 10 00001004 132 rs168965 74 2 logistic microalbuminuria or macroalbuminuria vs control (at entry) 14 00001004 152 rs6737578 5 7 logistic GE ₁ AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00001005 252 rs1356704 42 7 logistic macroalbuminuria vs no albuminuria (at entry) 2 00001005 063 rs1930994 130 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 00001006 075 rs16825798 186 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00001006 052 rs9924993 27 3 logistic albuminuria vs no albuminuria (follow-up) 16 00001007 072 rs709934 239 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00001008 148 rs6657700 288 4 logistic low glomerular fitration rate vs control (follow-up) 1 00001009 180 rs17251278 106 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00001009 069 rs4339624 83 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 00001011 064 rs10935316 152 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00001012 166 rs980907 50 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 13 00001012 068 rs1529289 131 7 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00001013 071 rs344701 28 4 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 5 00001013 072 rs12595945 65 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 16 00001014 065 rs9391062 111 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001014 076 rs13333226 38 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 00001014 066 rs4656799 188 6 logistic low glomerular fitration rate vs control (follow-up) 1 00001016 156 rs10759765 103 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 9 00001021 074 rs2176696 42 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00001021 063 rs17025554 113 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00001023 068 rs11185172 140 1 logistic albuminuria vs no albuminuria (at entry) 1 00001024 130

rs1529289 131 7 logistic low creatinine clearance vs normal creatinine clearance 2 00001024 070 rs7764326 164 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001025 140 rs2090018 44 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 17 00001025 070 rs12962651 87 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00001026 071 rs3883317 63 9 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 17 00001026 211 rs2324872 50 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 13 00001027 070 rs4736185 158 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00001028 069 rs4266861 208 7 logistic albuminuria vs no albuminuria (follow-up) 1 00001029 145 rs6926642 166 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00001029 073 rs4339624 83 6 logistic low creatinine clearance vs normal creatinine clearance 8 0000103 061 rs1860192 11 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 19 0000103 142 rs7982077 18 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 13 0000103 067 rs10242865 111 8 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00001031 132 rs7985116 86 0 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00001031 069 rs17258731 146 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001032 156 rs9924993 27 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 16 00001032 072 rs4923872 38 3 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 15 00001036 145 rs17399090 91 6 logistic albuminuria vs no albuminuria (follow-up) 9 00001036 074 rs2646261 252 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00001036 158 rs10792617 84 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 11 00001037 153 rs2445290 9 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 11 00001038 147 rs704829 191 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 00001038 140 rs2654981 112 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 15 0000104 077 rs807525 41 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 0000104 064 rs1530104 131 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 00001042 063 rs10894319 137 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00001043 073 rs11204592 288 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 00001044 147 rs16880395 43 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 4 00001047 073 rs11735854 43 3 logistic albuminuria vs no albuminuria (follow-up) 4 00001047 075 rs1002170 3 0 logistic macroalbuminuria vs no albuminuria (at entry) 7 00001047 053 rs1002170 3 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 00001047 053 rs16967971 56 8 logistic microalbuminuria vs no albuminuria (at entry) 19 00001047 199 rs10894319 137 3 logistic microalbuminuria vs no albuminuria (at entry) 11 00001047 073 rs12973797 58 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 19 0000105 067 rs6960707 142 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 00001051 157 rs2372905 109 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00001051 076 rs7220293 74 1 logistic HBP microalbuminuria vs no albuminuria (at entry) 17 00001052 117 rs12656061 130 8 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00001053 159 rs924640 56 1 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00001053 213 rs2932966 36 4 logistic microalbuminuria vs no albuminuria (at entry) 4 00001054 137

rs765 450 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 15 00001054 071 rs11624722 515 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 14 00001055 068 rs765188 523 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00001056 076 rs7651436 68 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 3 00001058 276 rs2185427 102 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00001058 132 rs6095323 71 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 20 00001058 071 rs10978612 112 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00001059 158 rs7203172 48 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 16 00001059 063 rs7229063 109 3 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 0000106 140 rs4597881 77 5 logistic low glomerular fitration rate vs control (follow-up) 4 0000106 152 rs355460 77 5 logistic low glomerular fitration rate vs control (follow-up) 4 0000106 152 rs9351813 84 1 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 00001061 157 rs10234057 66 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00001062 140 rs1860192 11 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 19 00001062 142 rs10904339 11 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 10 00001063 069 rs10816423 112 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00001066 157 rs2833998 30 2 logistic microalbuminuria vs no albuminuria (at entry) 21 00001066 134 rs6578592 10 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00001068 070 rs10248275 5 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 7 00001069 182 rs9505117 11 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 0000107 132 rs16967971 56 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 19 0000107 199 rs2962792 41 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 00001072 055 rs10787476 132 0 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 10 00001073 181 rs1526591 71 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 00001073 179 rs194869 95 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 20 00001073 156 rs6595512 131 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001073 145 rs922554 131 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001073 145 rs7705236 131 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001073 145 rs922555 131 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001073 145 rs922553 131 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001073 145 rs922552 131 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001073 145 rs485056 243 5 logistic albuminuria vs no albuminuria (at entry) 1 00001074 069 rs11054588 17 0 logistic albuminuria vs no albuminuria (follow-up) 12 00001075 053 rs12962651 87 2 logistic low creatinine clearance vs normal creatinine clearance 18 00001075 071 rs17654227 66 4 logistic microalbuminuria vs no albuminuria (at entry) 7 00001075 140 rs10978601 112 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00001076 158 rs1764844 239 1 logistic low glomerular fitration rate vs control (at entry) 1 00001076 151 rs2176696 42 7 logistic macroalbuminuria vs no albuminuria (at entry) 2 00001076 063 rs6665381 97 8 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00001079 162 rs610494 699 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 20 00001081 074

rs8187945 67 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 9 00001081 240 rs11688740 80 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00001082 164 rs41530345 66 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 00001084 157 rs7199582 85 1 logistic low creatinine clearance vs normal creatinine clearance 16 00001085 176 rs3820821 46 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00001085 043 rs3753305 187 5 logistic microalbuminuria vs no albuminuria (at entry) 1 00001085 075 rs10034306 33 2 logistic albuminuria vs no albuminuria (follow-up) 4 00001089 077 rs2962615 5 9 logistic low glomerular titration rate vs control (at entry) 5 0000109 150 rs17761559 125 6 logistic AGE, SEX low glomerular titration rate vs control (at entry) 10 00001092 166 rs1507727 1 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00001092 154 rs2841941 251 3 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 1 00001093 148 rs10875745 63 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00001093 128 rs6472334 83 6 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 8 00001096 064 rs6508259 50 7 logistic albuminuria vs no albuminuria (at entry) 18 00001096 135 rs7764326 164 5 logistic albuminuria vs no albuminuria (at entry) 6 00001097 140 rs257654 103 2 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 19 00001097 152 rs10904339 11 5 logistic albuminuria vs no albuminuria (at entry) 10 00001098 069 rs363029 26 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 20 00001098 061 rs6701181 262 8 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 1 000011 072 rs7570424 232 3 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 2 000011 058 rs6750269 232 3 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 2 000011 058 rs7609541 232 3 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 2 000011 058 rs7556846 232 3 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 2 000011 058 rs4883520 168 2 logistic macroalbuminuria vs no albuminuria (at entry) 12 00001101 058 rs10788901 75 6 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 1 00001102 062 rs9634125 17 0 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 12 00001102 053 rs17043569 19 8 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 3 00001102 180 rs11595123 11 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 10 00001102 068 rs6985315 115 8 logistic GE ₁ AGE ₁ SEX low glomerular titration rate vs control (at entry) 8 00001103 063 rs9639468 38 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 7 00001103 145 rs2699367 131 7 logistic low creatinine clearance vs normal creatinine clearance 2 00001103 070 rs610494 69 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 20 00001103 075 rs254287 136 0 logistic low glomerular titration rate vs control (at entry) 5 00001104 200 rs12616972 238 2 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 2 00001105 144 rs9505118 11 5 logistic albuminuria vs no albuminuria (follow-up) 6 00001105 132 rs6472334 83 6 logistic low creatinine clearance vs normal creatinine clearance 8 00001106 062 rs3909788 125 5 logistic GE ₁ AGE ₁ SEX low glomerular titration rate vs control (follow-up) 12 00001107 062 rs10989294 102 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 9 00001107 059 rs8098626 68 2 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00001107 072 rs7228353 106 7 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 18 00001108 077

rs10106008 32 7 logistic GE, AGE, SEX microalbuminuria or Microalbuminuria vs control (follow-up) 8 0000111 056 rs4279411 166 6 logistic GE ₁ AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 6 00001112 073 rs632248 83 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00001112 144 rs2912020 8 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 00001112 068 rs7136397 594 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00001112 145 rs2699367 131 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 00001113 064 rs2035219 29 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00001114 053 rs2736172 44 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001116 133 rs6595512 131 3 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001116 145 rs922554 131 3 logistic GE ₁ AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001116 145 rs922553 131 3 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001116 145 rs922552 131 3 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001116 145 rs7705236 131 3 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001116 145 rs922555 131 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001116 145 rs12895787 91 6 logistic albuminuria vs no albuminuria (at entry) 14 00001117 154 rs11735854 43 3 logistic low glomerular fitration rate vs control (follow-up) 4 00001118 064 rs4883520 168 2 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 00001121 058 rs2190963 23 2 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 17 00001123 214 rs1143694 102 6 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 10 00001123 133 rs7301998 59 4 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 00001123 144

OO rs9364534 164 4 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (at entry) 6 00001124 138 rs11152369 76 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00001126 043 rs858942 72 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00001126 178 rs6676401 244 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00001128 222 rs12956604 109 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 18 00001129 148 rs2158951 66 4 logistic microalbuminuria vs no albuminuria (at entry) 7 00001129 139 rs12966869 94 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 18 0000113 047 rs4773709 72 3 logistic macroalbuminuria vs no albuminuria (at entry) 13 0000113 167 rs424301 21 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 9 00001131 142 rs10122952 112 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00001132 157 rs11118204 239 1 logistic low glomerular fitration rate vs control (at entry) 1 00001132 159 rs6960707 142 5 logistic macroalbuminuria vs no albuminuria (at entry) 7 00001133 157 rs7668533 77 5 logistic low glomerular fitration rate vs control (follow-up) 4 00001134 152 rs7695033 95 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 00001136 169 rs11030008 7 6 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 11 00001136 132 rs4535211 41 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 3 00001136 155 rs1929751 59 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 13 00001136 064 rs4955814 73 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00001136 135 rs2620772 78 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00001137 074 rs6508259 50 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 18 00001138 135

rs4128841 251 2 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 1 00001139 148 rs2841941 251 3 logistic AGE, SEX low glomerular titration rate vs control (at entry) 1 00001141 143 rs17609252 177 3 logistic low creatinine clearance vs normal creatinine clearance 4 00001141 146 rs6578592 10 2 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00001141 070 rs379060 157 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 5 00001141 079 rs8187945 67 8 logistic AGE, SEX low glomerular titration rate vs control (at entry) 9 00001142 227 rs9646596 76 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00001142 044 rs7123971 98 2 logistic macroalbuminuria vs no albuminuria (at entry) 11 00001142 353 rs4736185 158 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00001142 069 rs1647965 137 3 logistic microalbuminuria vs no albuminuria (at entry) 11 00001143 073 rs7977693 96 0 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00001146 141 rs2445290 9 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 11 00001148 147 rs11131154 294 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00001148 052 rs4773709 72 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00001148 167 rs2158951 664 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00001148 139 rs2324872 504 logistic microalbuminuria or macroalbuminuria vs control (at entry) 13 00001148 070 rs9300777 86 0 logistic GE ₁ AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00001149 143 rs2194325 80 2 logistic low glomerular titration rate vs control (at entry) 16 0000115 153 rs3813582 104 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 0000115 141 rs1344311 45 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 15 00001155 072 rs11054588 17 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00001156 053 rs6810410 77 5 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 4 00001158 150 rs10780235 78 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 00001158 188 rs17686287 7 9 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 5 00001159 191 rs7302914 17 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00001159 055 rs4936167 141 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 11 00001159 048 rs2354324 68 0 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 14 0000116 141 rs1647965 137 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00001161 073 rs1647965 137 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00001163 075 rs11123021 131 6 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 2 00001165 071 rs130834 58 3 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 22 00001165 207 rs17076524 145 7 logistic low glomerular titration rate vs control (follow-up) 6 00001166 193 rs2812657 62 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00001166 141 rs194869 95 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 20 00001166 156 rs2003013 110 8 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 11 00001167 035 rs2176775 124 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 16 00001167 079 rs2932966 364 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 4 00001168 137 rs17649038 153 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 8 00001168 079 rs2419533 131 2 logistic low glomerular titration rate vs control (at entry) 4 00001169 167 rs7705409 131 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001169 144

rs6582 384 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 15 0 000117 1 34 rs10459785 27 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 16 0 0001172 0 73 rs4663165 245 2 logistic GE, AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 2 0 0001172 1 59 rs 10504846 102 0 logistic HBP microalbuminuria vs no albuminuria (at entry) 8 0 0001172 1 51 rs12895787 91 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 14 0 0001175 1 54 rs12966800 87 3 logistic low creatinine clearance vs normal creatinine clearance 18 0 0001175 0 71 rs10894319 137 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 0 0001176 0 75 rs17043569 19 8 logistic AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 3 0 0001177 1 80 rs7705409 131 3 logistic GE, AGE, SEX microalbuminuria or microalbuminuria vs control (follow-up) 5 0 0001178 1 44 rs41454946 22 0 logistic microalbuminuria or microalbuminuria vs control (follow-up) 11 0 0001179 0 60 rs12485415 42 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 3 0 000118 2 09 rs4790200 10 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 17 0 000118 2 17 rs2282367 102 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 10 0 0001183 1 32 rs6831405 205 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 4 0 0001185 1 24 rs4775698 44 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 15 0 0001186 1 32 rs10034306 33 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 0 0001187 0 77 rs10894319 137 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 0 0001188 0 73 rs 1529289 131 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 0 0001189 0 63 rs 1363697 163 1 logistic albuminuria vs no albuminuria (at entry) 5 0 0001189 0 74 rs4846657 239 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 1 0 0001189 0 74 rs10111251 106 2 logistic AGE, SEX microalbuminuria or microalbuminuria vs control (follow-up) 8 0 0001189 0 52 rs13110738 124 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 4 0 000119 1 51 rs17343615 38 0 logistic low glomerular fitration rate vs control (follow-up) 5 0 0001193 1 80 rs4940497 87 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 0 0001193 0 72 rs6508259 50 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 18 0 0001193 1 37 rs7621243 42 1 logistic microalbuminuria or microalbuminuria vs control (at entry) 3 0 0001193 0 62 rs858942 72 7 logistic microalbuminuria or microalbuminuria vs control (follow-up) 2 0 0001193 1 78 rs4728666 98 0 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 0 0001194 1 28 rs1344311 45 0 logistic AGE, SEX microalbuminuria or microalbuminuria vs control (at entry) 15 0 0001194 0 72 rs6472346 83 6 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 0 0001195 0 53 rs17043569 19 8 logistic microalbuminuria vs no albuminuria (at entry) 3 0 0001196 1 80 rs12609410 103 1 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 19 0 0001196 1 51 rs6508259 50 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 18 0 0001196 1 37 rs10233697 66 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 0 0001197 1 41 rs922556 131 3 logistic AGE, SEX microalbuminuria or microalbuminuria vs control (follow-up) 5 0 0001197 1 44 rs4923872 38 3 logistic low creatinine clearance vs normal creatinine clearance 15 0 0001198 1 40 rs17654227 66 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 0 0001199 1 40 rs782113 71 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 0 00012 1 29 rs6583607 164 7 logistic microalbuminuria or microalbuminuria vs control (follow-up) 8 0 00012 0 71 rs2090980 84 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 11 0 0001202 1 54

rs10970744 56.1 logistic GE, AGE, SEX low creatinine clearance vs. normal creatinine clearance 9 0.0001202 1.39 rs1356952 134.5 logistic GE, AGE, SEX microalbuminuria vs. no albuminuria (at entry) 12 0.0001203 1.44 rs6803927 24.7 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 3 0.0001203 0.72 rs4369676 38.9 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 16 0.0001204 0.66 rs4321205 38.9 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 16 0.0001204 0.66 rs4280249 38.9 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 16 0.0001204 0.66 rs17680905 43.3 logistic low glomerular fitration rate vs. control (at entry) 4 0.0001206 0.62 rs1866479 131.6 logistic GE, AGE, SEX low glomerular fitration rate vs. control (follow-up) 2 0.0001207 0.68 rs10935316 152.3 logistic macroalbuminuria vs. no albuminuria (at entry) 3 0.0001207 1.66 rs634585 50.4 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 13 0.0001208 0.68 rs1434764 84.0 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 8 0.0001209 0.76 rs1545074 131.2 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 4 0.0001209 1.59 rs13316352 172.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 3 0.0001209 1.46 rs7406339 48.6 logistic AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 17 0.0001211 1.33 rs6809087 41.8 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 3 0.0001212 1.54 rs8044632 67.2 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 16 0.0001212 1.33 rs13438289 147.5 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 7 0.0001214 1.38 rs17242747 32.1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 11 0.0001215 0.70 rs12911453 70.1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 15 0.0001216 1.42 rs6926642 166.6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 6 0.0001216 0.73 rs485056 243.5 logistic GE, AGE, SEX albuminuria vs. no albuminuria (at entry) 1 0.0001217 0.69 rs1322051 49.1 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 9 0.0001217 0.47 rs1240385 107.4 logistic macroalbuminuria vs. no albuminuria (at entry) 10 0.0001218 2.77 rs6095323 71.6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 20 0.0001219 0.71 rs11183154 59.3 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 12 0.000122 0.65 rs7203172 48.8 logistic albuminuria vs. no albuminuria (follow-up) 16 0.0001221 0.66 rs17696165 151.7 logistic GE, AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 7 0.0001222 1.84 rs11156316 111.4 logistic AGE, SEX albuminuria vs. no albuminuria (at entry) 6 0.0001223 0.76 rs8098626 68.2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 18 0.0001223 0.72 rs4276176 90.2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 3 0.0001223 0.66 rs2324872 50.4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 13 0.0001224 0.70 rs16848600 191.7 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 1 0.0001224 0.45 rs6446391 11.0 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 4 0.0001225 1.70 rs2220521 172.8 logistic AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 3 0.0001225 0.59 rs7406339 48.6 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 17 0.0001226 1.33 rs7748736 11.5 logistic AGE, SEX albuminuria vs. no albuminuria (at entry) 6 0.0001228 1.30 rs4128841 251.2 logistic low glomerular fitration rate vs. control (follow-up) 1 0.000123 1.48 rs882869 264.9 logistic macroalbuminuria vs. no albuminuria (at entry) 1 0.000123 1.56 rs304215 84.4 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 3 0.0001231 0.72 rs10968723 6.8 logistic low creatinine clearance vs. normal creatinine clearance 9 0.0001231 1.41

rs485056 243 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00001232 069 rs1258323 69 7 logistic low glomerular titration rate vs control (follow-up) 10 00001233 068 rs2677810 251 3 logistic AGE, SEX low glomerular titration rate vs control (at entry) 1 00001234 142 rs4130030 101 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 00001236 138 rs6780191 41 8 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 3 00001237 150 rs6595512 131 3 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 5 00001238 133 rs922554 131 3 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 5 00001238 133 rs922552 131 3 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 5 00001238 133 rs7705236 131 3 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 5 00001238 133 rs922553 131 3 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 5 00001238 133 rs9391062 111 4 logistic albuminuria vs no albuminuria (at entry) 6 00001239 076 rs17799065 156 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 7 00001239 048 rs130834 58 3 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 22 0000124 207 rs4141372 31 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 7 0000124 077 rs4333309 130 3 logistic GE ₁ AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 5 0000124 155 rs289450 108 9 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 15 0000124 051 rs1545741 93 8 logistic microalbuminuria vs no albuminuria (at entry) 12 00001241 233 rs922556 131 3 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001242 144 rs1334237 41 4 logistic low glomerular titration rate vs control (follow-up) 13 00001243 152 rs9675700 87 3 logistic low creatinine clearance vs normal creatinine clearance 18 00001244 071 rs6803927 24 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00001246 072 rs1986877 55 3 logistic AGE, SEX low glomerular titration rate vs control (at entry) 7 00001247 065 rs4586627 226 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 2 00001248 076 rs9505118 11 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 0000125 132 rs13110738 124 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 4 0000125 151 rs7982376 73 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 13 00001251 068 rs3790990 252 4 logistic microalbuminuria vs no albuminuria (at entry) 2 00001251 144 rs13249327 83 6 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 8 00001252 065 rs4775698 44 9 logistic albuminuria vs no albuminuria (follow-up) 15 00001252 132 rs10780235 78 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 00001253 188 rs9908767 44 1 logistic microalbuminuria vs no albuminuria (at entry) 17 00001253 069 rs829573 48 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 2 00001255 069 rs4535211 41 8 logistic GE ₁ AGE ₁ SEX low glomerular titration rate vs control (follow-up) 3 00001258 155 rs7705409 131 3 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 5 00001258 133 rs2932966 36 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00001258 141 rs1549840 76 6 logistic low glomerular titration rate vs control (at entry) 2 00001259 150 rs11131154 29 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 0000126 052 rs6665381 97 8 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00001261 162 rs1402337 134 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00001261 144 rs9368402 39 2 logistic low glomerular titration rate vs control (at entry) 6 00001262 148

rs2873929 77 5 logistic low glomerular titration rate vs control (follow-up) 4 00001262 151 rs7655850 77 5 logistic low glomerular titration rate vs control (follow-up) 4 00001262 151 rs6960707 142 5 logistic GE, AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 7 00001263 157 rs2254193 31 1 logistic HBP microalbuminuria vs no albuminuria (at entry) 9 00001264 146 rs10430114 79 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 1 00001265 071 rs10858809 94 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 00001265 171 rs6508259 50 7 logistic microalbuminuria vs no albuminuria (at entry) 18 00001266 137 rs4130030 101 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 8 00001266 138 rs7301998 59 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00001266 144 rs4456715 131 7 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 2 00001267 068 rs11123021 131 6 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 2 00001269 069 rs4235846 98 9 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 6 0000127 169 rs10858809 94 7 logistic macroalbuminuria vs no albuminuria (at entry) 12 0000127 171 rs7281608 17 9 logistic AGE, SEX low glomerular titration rate vs control (at entry) 21 00001272 159 rs2158951 664 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00001273 139 rs2841941 251 3 logistic low glomerular titration rate vs control (follow-up) 1 00001274 148 rs6472345 83 6 logistic low creatinine clearance vs normal creatinine clearance 8 00001274 062 rs6052724 12 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 20 00001274 137 rs2862907 10 3 logistic low glomerular titration rate vs control (follow-up) 13 00001274 161 rs1461237 156 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00001276 139 rs2949644 110 5 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 4 00001281 127 rs1510294 123 7 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 6 00001282 135 rs17029949 13 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 3 00001282 273 rs183117 67 1 logistic HBP microalbuminuria vs no albuminuria (at entry) 8 00001283 080 rs7628779 48 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 00001285 162 rs4303932 158 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00001285 131 rs2023968 3 1 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 7 00001286 071 rs2000833 87 2 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 18 00001286 073 rs9505117 11 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00001286 132 rs1636307 35 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 7 00001287 075 rs1392695 113 9 logistic low glomerular Titration rate vs normal glom filtration rate (follow-up) 3 00001288 140 rs7834887 1384 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 8 00001288 211 rs6809087 41 8 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 3 00001289 154 rs17399090 91 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 00001289 066 rs2932966 36 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 4 0000129 134 rs12543318 101 9 logistic macroalbuminuria vs no albuminuria (at entry) 8 00001292 061 rs3762365 177 5 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00001293 131 rs17641512 40 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 13 00001293 063 rs7334517 40 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 13 00001293 063 rs4667810 168 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00001294 132

rs360087 242 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 1 00001295 146 rs7624432 190 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 00001295 226 rs11810706 191 8 logistic microalbuminuria vs no albuminuria (at entry) 1 00001295 134 rs10034306 33 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00001296 077 rs7501838 63 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 17 00001296 212 rs11144203 70 6 logistic low creatinine clearance vs normal creatinine clearance 9 00001297 151 rs1647965 137 3 logistic albuminuria vs no albuminuria (at entry) 11 00001298 075 rs10989294 102 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 00001298 059 rs4394376 83 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 00001299 065 rs12539092 121 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 00001299 173 rs1472610 32 5 logistic low creatinine clearance vs normal creatinine clearance 5 000013 053 rs9351813 84 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 000013 157 rs10787476 132 0 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00001301 181 rs829584 48 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 2 00001302 069 rs1258241 69 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 10 00001304 066 rs3753305 187 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00001305 075 rs4663113 133 4 logistic low glomerular fitration rate vs control (follow-up) 2 00001306 150 rs2932966 364 logistic albuminuria vs no albuminuria (at entry) 4 00001307 134 rs11707121 59 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00001307 132 rs12258211 81 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 10 00001307 159 rs603151 26 3 logistic low glomerular fitration rate vs control (at entry) 1 00001308 157 rs1363697 163 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00001308 074 rs584125 83 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00001308 144 rs11070285 38 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 15 0000131 146 rs355483 77 5 logistic low glomerular fitration rate vs control (follow-up) 4 00001312 151 rs10935316 152 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00001312 166 rs2503293 111 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001315 076 rs6658141 288 4 logistic low glomerular fitration rate vs control (at entry) 1 00001317 171 rs7301998 59 4 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 12 00001317 149 rs10894319 137 3 logistic albuminuria vs no albuminuria (at entry) 11 00001317 075 rs9354486 82 3 logistic albuminuria vs no albuminuria (at entry) 6 00001317 077 rs2962615 5 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 00001317 127 rs7027322 27 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 9 00001317 070 rs10459785 27 3 logistic albuminuria vs no albuminuria (follow-up) 16 00001318 073 rs1218661 262 1 logistic albuminuria vs no albuminuria (follow-up) 1 0000132 130 rs902891 159 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 12 0000132 135 rs10845092 20 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 0000132 023 rs2420378 187 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 00001324 141 rs7567280 186 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00001324 073 rs1530211 151 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 3 00001325 075

rs11152369 768 logistic albuminuria vs no albuminuria (follow-up) 18 00001325 043 rs7748736 11 5 logistic albuminuria vs no albuminuria (at entry) 6 00001331 130 rs17709552 62 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00001331 061 rs6944568 3 1 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 7 00001333 071 rs1327210 504 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00001333 068 rs1866479 131 6 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00001334 068 rs8089273 94 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 18 00001334 048 rs4279411 166 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00001334 074 rs12543318 101 9 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 8 00001335 061 rs7747551 130 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 00001335 075 rs1647966 137 3 logistic microalbuminuria vs no albuminuria (at entry) 11 00001336 073 rs2267889 120 7 logistic GE ₁ AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 00001336 054 rs12508383 131 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 4 00001337 157 rs7695033 95 2 logistic low glomerular fitration rate vs control (follow-up) 4 00001339 224 rs622917 46 5 logistic albuminuria vs no albuminuria (follow-up) 6 0000134 077 rs4321205 38 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 0000134 073 rs4280249 38 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 0000134 073 rs4369676 38 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 0000134 073 rs4940497 87 4 logistic low creatinine clearance vs normal creatinine clearance 18 00001342 072 rs10897992 72 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 11 00001343 059

4- rs10501407 72 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 11 00001343 059 rs2960744 151 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 7 00001343 073 rs7748736 11 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00001344 132 rs2368053 101 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 12 00001344 066 rs7302914 17 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00001345 055 rs1647966 137 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00001346 073 rs4741833 0 8 logistic HBP ₁ diabetes duration microalbuminuria vs no albuminuria (at entry) 9 00001346 079 rs7237496 87 2 logistic low creatinine clearance vs normal creatinine clearance 18 00001347 071 rs12361671 112 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 11 00001349 157 rs485056 243 5 logistic microalbuminuria vs no albuminuria (at entry) 1 0000135 067 rs16825798 186 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 3 0000135 052 rs1331484 0 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001351 135 rs1542481 96 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 12 00001351 128 rs1382394 87 3 logistic low creatinine clearance vs normal creatinine clearance 18 00001352 072 rs11183154 59 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00001353 065 rs2844032 60 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 11 00001353 059 rs980907 504 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00001354 068 rs1218661 262 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00001355 130 rs9908767 44 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 17 00001355 073 rs11897612 119 6 logistic low creatinine clearance vs normal creatinine clearance 2 00001355 139

rs1239771 125 1 logistic AGE ₁ SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 18 00001355 070 rs13273013 101 8 logistic low glomerular Titration rate vs control (at entry) 8 00001356 149 rs4789188 101 5 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 17 00001356 154 rs10867195 78 3 logistic GE, AGE, SEX macroalbumiπuπa vs no albuminuria (at entry) 9 00001356 206 rs41494550 191 7 logistic GE, AGE, SEX microalbuminuria or macroalbumiπuπa vs control (follow-up) 1 00001356 030 rs3104704 17 6 logistic low glomerular fitration rate vs control (at entry) 16 00001358 167 rs2254193 31 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 9 00001358 146 rs12446492 39 0 logistic low glomerular fitration rate vs control (at entry) 16 00001359 067 rs2677810 251 3 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 1 00001359 147 rs11707121 59 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00001359 132 rs10978612 112 5 logistic low glomerular fitration rate vs control (at entry) 9 00001361 182 rs962316 126 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00001361 135 rs194781 74 2 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 14 00001363 153 rs10787476 132 0 logistic low creatinine clearance vs normal creatinine clearance 10 00001364 181 rs1430377 87 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00001365 071 rs4321205 38 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00001366 073 rs4280249 38 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00001366 073 rs4369676 38 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00001366 073 rs7981243 18 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 13 00001367 067 rs2738079 9 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00001369 068

4- rs2239961 13 5 logistic low creatinine clearance vs normal creatinine clearance 22 0000137 148 rs191606 191 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 1 00001371 140 rs10894319 137 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00001371 075 rs1514417 17 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 21 00001372 154 rs10865331 81 5 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00001374 139 rs4141372 31 9 logistic albuminuria vs no albuminuria (follow-up) 7 00001374 077 rs16825798 1868 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00001374 052 rs10459785 27 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 16 00001377 073 rs1636307 35 2 logistic albuminuria vs no albuminuria (follow-up) 7 00001379 075 rs12604327 87 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00001379 072 rs1489922 172 8 logistic macroalbuminuria vs no albuminuria (at entry) 3 0000138 060 rs7302914 17 1 logistic albuminuria vs no albuminuria (follow-up) 12 00001381 055 rs619037 83 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00001381 140 rs12973797 58 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 19 00001382 067 rs17099254 74 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00001382 068 rs9874464 109 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00001382 077 rs1452420 38 5 logistic low glomerular fitration rate vs control (at entry) 2 00001386 152 rs2699367 131 7 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00001387 072 rs869346 91 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 14 00001388 155 rs7535769 191 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 1 0000139 139

rs9646596 768 logistic albuminuria vs no albuminuria (follow-up) 18 0000139 044 rs10166160 170 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 2 00001391 144 rs17272796 41 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 3 00001392 154 rs2404535 133 5 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 00001392 138 rs11803988 288 4 logistic low glomerular fitration rate vs control (follow-up) 1 00001394 177 rs1825443 107 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00001395 069 rs11707121 59 1 logistic albuminuria vs no albuminuria (follow-up) 3 00001396 132 rs9920163 39 9 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 15 00001397 143 rs6713 88 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00001397 057 rs7819717 98 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 8 00001397 075 rs635409 103 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00001397 049 rs9634125 17 0 logistic albuminuria vs no albuminuria (follow-up) 12 00001401 053 rs2646261 252 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 2 00001402 150 rs2248922 262 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00001402 129 rs226832 69 8 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 20 00001402 077 rs2144825 132 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 14 00001405 141 rs11185172 140 1 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (at entry) 1 00001405 130 rs603151 26 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 1 00001407 157 rs6883415 164 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00001407 182 rs12361671 112 8 logistic albuminuria vs no albuminuria (follow-up) 11 00001409 157 rs10465473 248 3 logistic macroalbuminuria vs no albuminuria (at entry) 1 00001409 059 rs10489185 187 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00001409 140 rs226832 69 8 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 20 0000141 077 rs10495829 53 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 2 0000141 302 rs2146162 164 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001411 139 rs922556 131 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00001411 133 rs12775879 132 0 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 10 00001412 177 rs4424038 156 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 00001413 138 rs1647965 137 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00001414 073 rs2185427 102 6 logistic albuminuria vs no albuminuria (follow-up) 10 00001416 132 rs726820 106 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00001416 141 rs9834708 112 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00001417 069 rs10495829 53 5 logistic albuminuria vs no albuminuria (follow-up) 2 00001419 234 rs4643103 84 9 logistic GE ₁ AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00001421 136 rs778340 239 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00001422 147 rs11688740 80 0 logistic macroalbuminuria vs no albuminuria (at entry) 00001424 164 rs6814897 95 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00001425 197 rs10482872 4 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 21 00001425 195 rs9420501 102 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 10 00001425 135 rs7236715 41 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 00001425 145

rs7870302 157 3 logistic low glomerular fitration rate vs control (follow-up) 9 00001428 163 rs6657700 2884 logistic low glomerular fitration rate vs control (at entry) 1 00001429 171 rs7748736 11 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001429 130 rs10751020 84 3 logistic microalbuminuria vs no albuminuria (at entry) 11 00001429 075 rs1628249 105 2 logistic low glomerular fitration rate vs control (follow-up) 9 0000143 149 rs16901597 138 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 8 00001433 245 rs16880395 43 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00001433 066 rs6518240 55 1 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 21 00001436 145 rs10238177 90 6 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00001436 133 rs6518240 55 1 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 21 00001437 145 rs1558531 17 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00001437 053 rs4936618 117 8 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00001437 069 rs858942 72 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 2 00001437 166 rs3809485 45 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 15 00001439 071 rs2921571 12 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00001441 151 rs3883317 63 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 17 00001442 211 rs7765427 91 2 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 00001443 149 rs9354486 82 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001445 077 rs2248922 262 1 logistic albuminuria vs no albuminuria (follow-up) 1 00001445 129 rs10780235 78 3 logistic macroalbuminuria vs no albuminuria (at entry) 9 00001446 188

4-

OO rs17709552 62 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00001447 061 rs9908767 44 1 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 17 00001447 069 rs782103 71 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 00001447 128 rs622917 46 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00001449 077 rs41494550 191 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00001449 038 rs10814269 0 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 9 00001451 076 rs10188434 119 5 logistic low creatinine clearance vs normal creatinine clearance 2 00001452 139 rs2566349 93 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00001454 135 rs734442 164 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 00001457 079 rs10904339 11 5 logistic microalbuminuria vs no albuminuria (at entry) 10 00001457 067 rs10781448 77 1 logistic low glomerular fitration rate vs control (follow-up) 9 00001459 151 rs11810706 191 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 0000146 139 rs1999717 18 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 13 0000146 067 rs4866542 7 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00001462 063 rs6578592 10 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 11 00001463 070 rs1396512 63 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 00001463 161 rs2962792 41 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00001464 058 rs7761326 82 2 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 00001464 162 rs246277 130 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 5 00001464 162 rs12595945 65 1 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 16 00001465 065

rs10155009 96 8 logistic low glomerular titration rate vs control (follow-up) 3 00001466 061 rs9309308 45 0 logistic low glomerular titration rate vs control (follow-up) 2 00001467 164 rs11652482 54 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 17 00001467 154 rs4985702 44 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 17 00001469 073 rs4663113 133 4 logistic low creatinine clearance vs normal creatinine clearance 2 00001469 140 rs7233192 87 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00001469 071 rs535620 65 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 1 00001473 081 rs17600042 108 7 logistic microalbuminuria vs no albuminuria (at entry) 7 00001474 050 rs7747972 82 2 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 00001477 162 rs12602903 74 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 17 00001478 156 rs13316352 172 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 3 00001478 146 rs3909788 125 5 logistic AGE ₁ SEX low creatinine clearance vs normal creatinine clearance 12 0000148 072 rs168965 74 2 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 14 0000148 152 rs12826155 71 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 00001483 124 rs10496309 106 2 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 2 00001487 068 rs2353545 222 0 logistic macroalbuminuria vs no albuminuria (at entry) 1 00001487 156 rs858942 72 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 00001487 166 rs7982077 18 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 13 00001487 067 rs10982727 123 6 logistic macroalbuminuria vs no albuminuria (at entry) 9 00001488 163 rs922555 131 3 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up)

4- 5 0000149 132 rs3112857 198 8 logistic low creatinine clearance vs normal creatinine clearance 4 00001491 141 rs2960744 151 1 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00001492 073 rs1430382 87 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00001493 070 rs2353545 222 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00001493 156 rs7194394 107 5 logistic macroalbuminuria vs no albuminuria (at entry) 16 00001496 168 rs11156316 111 4 logistic albuminuria vs no albuminuria (at entry) 6 00001497 076 rs12403846 248 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00001498 075 rs28490018 114 7 logistic AGE ₁ SEX low glomerular titration rate vs control (follow-up) 14 00001499 055 rs2962792 41 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00001499 058 rs10495829 53 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00001499 234 rs6810410 77 5 logistic low glomerular titration rate vs control (follow-up) 4 00001501 150 rs9502593 11 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00001502 131 rs3863992 158 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 3 00001502 150 rs682970 29 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 10 00001503 228 rs550523 26 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00001504 144 rs1825443 107 4 logistic albuminuria vs no albuminuria (follow-up) 8 00001506 069 rs2864246 136 7 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 5 00001506 061 rs3917786 187 5 logistic microalbuminuria vs no albuminuria (at entry) 1 00001506 076 rs4677766 220 1 logistic GE ₁ AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00001508 057 rs1334811 49 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 00001508 049

rs6488711 31.3 logistic AGE ₁ SEX albuminuria vs. no albuminuria (at entry) 12 0.0001509 0.68 rs2420378 187.5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 1 0.000151 1.41 rs17509991 76.8 logistic AGE, SEX albuminuria vs. no albuminuria (follow-up) 18 0.0001511 0.44 rs3790990 252.4 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 2 0.0001511 1.44 rs304209 84.4 logistic AGE, SEX low glomerular titration rate vs. control (follow-up) 3 0.0001513 0.71 rs2949650 110.4 logistic GE, AGE, SEX low glomerular fitration rate vs. control (follow-up) 4 0.0001513 1.28 rs12403846 248.3 logistic albuminuria vs. no albuminuria (at entry) 1 0.0001513 0.75 rs4659819 258.8 logistic AGE, SEX albuminuria vs. no albuminuria (follow-up) 1 0.0001513 0.78 rs1461237 156.9 logistic albuminuria vs. no albuminuria (at entry) 5 0.0001514 1.39 rs12713469 81.8 logistic albuminuria vs. no albuminuria (follow-up) 2 0.0001514 1.30 rs4712300 33.5 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 6 0.0001516 0.66 rs41530345 66.0 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 9 0.0001517 1.77 rs10430114 79.7 logistic AGE, SEX albuminuria vs. no albuminuria (at entry) 1 0.0001518 0.71 rs8099832 87.2 logistic GE, AGE, SEX low creatinine clearance vs. normal creatinine clearance 18 0.0001518 0.70 rs10904339 11.5 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 10 0.0001518 0.67 rs1647965 137.3 logistic GE ₁ AGE ₁ SEX albuminuria vs. no albuminuria (at entry) 11 0.0001519 0.75 rs12485415 42.4 logistic GE, AGE, SEX microalbuminuria vs. no albuminuria (at entry) 3 0.000152 2.05 rs4543225 60.7 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 5 0.0001522 0.77 rs3762365 177.5 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 1 0.0001523 1.31 rs10070326 8.0 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 5 0.0001523 3.68

O rs2359630 16.9 logistic GE ₁ AGE ₁ SEX microalbuminuria vs. no albuminuria (at entry) 4 0.0001523 1.32 rs11097065 95.2 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 4 0.0001524 1.95 rs6488711 31.3 logistic albuminuria vs. no albuminuria (at entry) 12 0.0001524 0.68 rs10867190 78.3 logistic macroalbuminuria vs. no albuminuria (at entry) 9 0.0001524 2.02 rs9351813 84.1 logistic macroalbuminuria vs. no albuminuria (at entry) 6 0.0001524 1.57 rs7194394 107.5 logistic AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 16 0.0001524 1.68 rs7123971 98.2 logistic AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 11 0.0001525 3.53 rs4130030 101.8 logistic low glomerular fitration rate vs. control (at entry) 8 0.0001526 1.49 rs10792617 84.9 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 11 0.0001529 1.36 rs882869 264.9 logistic GE, AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 1 0.0001529 1.56 rs10070326 8.0 logistic low glomerular fitration rate vs. control (at entry) 5 0.000153 3.68 rs4403634 222.0 logistic macroalbuminuria vs. no albuminuria (at entry) 1 0.000153 1.56 rs 1765635 125.5 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 1 0.0001531 0.78 rs17670198 80.4 logistic GE, AGE, SEX albuminuria vs. no albuminuria (follow-up) 3 0.0001531 1.30 rs158687 97.0 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 9 0.0001532 0.72 rs9646596 76.8 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 18 0.0001533 0.39 rs963264 151.1 logistic low glomerular fitration rate vs. control (follow-up) 1 0.0001534 1.52 rs1975980 48.8 logistic low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 17 0.0001535 1.38 rs17487422 38.5 logistic AGE, SEX albuminuria vs. no albuminuria (follow-up) 14 0.0001535 1.43 rs7624432 190.9 logistic microalbuminuria vs. no albuminuria (at entry) 3 0.0001535 2.26

rs194782 742 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 14 00001535 151 rs7678921 77 5 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 4 00001536 144 rs9634125 17 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00001536 053 rs2654981 112 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 15 00001537 077 rs7748736 11 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00001537 132 rs12590361 132 2 logistic low creatinine clearance vs normal creatinine clearance 14 00001541 163 rs603151 26 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00001541 143 rs12055256 130 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 00001542 154 rs2104042 248 4 logistic AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 1 00001544 063 rs2104043 248 4 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00001544 063 rs194782 74 2 logistic microalbuminuria or macroalbuminuria vs control (at entry) 14 00001545 151 rs4586627 226 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 00001546 070 rs550523 26 3 logistic low creatinine clearance vs normal creatinine clearance 1 00001547 144 rs10867190 78 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 00001548 202 rs6673397 204 5 logistic low creatinine clearance vs normal creatinine clearance 1 00001549 230 rs11024875 22 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00001549 062 rs7197544 104 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 00001549 164 rs10485282 89 7 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 6 00001551 058 rs225549 146 9 logistic low glomerular titration rate vs control (follow-up) 12 00001551 064 rs11707973 152 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 3 00001551 070 rs17674649 42 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00001552 064 rs2146162 164 5 logistic albuminuria vs no albuminuria (at entry) 6 00001553 139 rs1411442 65 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 00001554 254 rs2706364 135 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 5 00001556 197 rs12795565 15 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00001556 061 rs1416079 113 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00001559 204 rs7203172 48 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 16 0000156 066 rs2914591 130 1 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 5 00001561 151 rs11707973 152 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00001561 070 rs9634205 96 1 logistic albuminuria vs no albuminuria (follow-up) 12 00001562 074 rs2026692 44 4 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00001562 157 rs615847 83 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00001563 140 rs829573 48 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00001566 069 rs12713469 81 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00001567 130 rs6018685 68 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 20 00001568 141 rs6501786 101 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 17 00001569 154 rs2503293 111 4 logistic albuminuria vs no albuminuria (at entry) 6 00001571 076 rs4600972 135 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 4 00001571 148 rs7272436 81 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 20 00001571 034 rs9364534 164 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001573 138

rs7248526 35 1 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 19 00001573 316 rs1647966 137 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00001573 073 rs1411441 65 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 00001574 254 rs10007275 8 6 logistic low creatinine clearance vs normal creatinine clearance 4 00001578 181 rs12446492 39 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 00001578 073 rs10430114 79 7 logistic albuminuria vs no albuminuria (at entry) 1 00001579 071 rs6996243 109 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 8 00001579 139 rs4645337 7 2 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00001579 063 rs4403634 222 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00001581 156 rs7236715 41 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00001581 145 rs7695033 95 2 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 00001586 169 rs17709552 62 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 11 00001586 062 rs1258241 69 7 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 10 00001587 066 rs1240385 107 4 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 10 00001587 277 rs3790990 252 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 00001588 144 rs2962792 41 1 logistic albuminuria vs no albuminuria (at entry) 5 00001589 058 rs12746741 116 1 logistic low creatinine clearance vs normal creatinine clearance 1 00001589 072 rs1569175 195 7 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 0000159 154 rs41521644 191 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 0000159 038 rs7977693 96 0 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 00001592 141

K> rs12192108 130 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 00001592 076 rs17272796 41 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 3 00001593 154 rs1416079 113 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00001593 161 rs2035187 78 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 00001593 050 rs2646261 252 5 logistic albuminuria vs no albuminuria (at entry) 2 00001594 150 rs3790990 252 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00001594 144 rs9325521 126 7 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00001595 143 rs10788562 102 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00001596 130 rs982296 92 8 logistic low creatinine clearance vs normal creatinine clearance 14 00001596 143 rs4236836 107 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00001597 131 rs4667810 168 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00001597 132 rs7193007 49 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 16 00001597 144 rs11927384 152 6 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 3 00001598 063 rs41494550 191 7 logistic albuminuria vs no albuminuria (follow-up) 1 00001598 038 rs10070326 8 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 5 00001599 408 rs162079 69 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 20 000016 139 rs17801910 78 0 logistic microalbuminuria vs no albuminuria (at entry) 12 000016 197 rs485056 243 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 1 00001601 067 rs924640 56 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 4 00001602 203 rs973358 25 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 17 00001602 074

σ ^>

rs10514925 639 logistic microalbuminuria or macroalbuminuria vs control (at entry) 17 00001603 205 rs11135724 46 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 8 00001604 070 rs4657486 177 4 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00001605 129 rs9926403 67 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 16 00001607 133 rs2254221 38 3 logistic low glomerular fitration rate vs control (follow-up) 2 00001607 067 rs17134275 108 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00001608 218 rs982926 130 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 00001608 139 rs7750426 166 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00001608 073 rs10193792 157 8 logistic low creatinine clearance vs normal creatinine clearance 2 00001609 066 rs634585 504 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00001609 068 rs17654227 664 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00001611 140 rs11082650 68 2 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00001611 067 rs13333226 38 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00001611 066 rs2135518 77 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 18 00001612 149 rs10105587 101 8 logistic low glomerular fitration rate vs control (at entry) 8 00001616 148 rs17186040 27 7 logistic macroalbuminuria vs no albuminuria (at entry) 13 00001616 062 rs11185172 140 1 logistic HBP microalbuminuria vs no albuminuria (at entry) 1 00001616 130 rs10759765 103 6 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 9 00001617 074 rs4543225 60 7 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00001618 077 rs17006815 47 4 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (at entry) 2 00001618 169

Ul rs10254929 66 3 logistic microalbuminuria vs no albuminuria (at entry) 7 00001618 138 rs733299 38 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 15 00001619 143 rs7832582 102 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00001622 057 rs2101210 127 7 logistic low creatinine clearance vs normal creatinine clearance 4 00001622 208 rs10514479 104 7 logistic albuminuria vs no albuminuria (follow-up) 16 00001624 192 rs4789189 101 5 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 17 00001624 153 rs1912278 106 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 10 00001625 165 rs7982376 73 8 logistic low glomerular fitration rate vs control (follow-up) 13 00001628 068 rs10872387 130 6 logistic HBP ₁ diabetes duration microalbuminuria vs no albuminuria (at entry) 6 00001628 076 rs13271014 88 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 8 00001629 172 rs10112627 88 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 8 00001629 172 rs10937662 11 0 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 0000163 171 rs17042372 41 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00001631 154 rs2962615 5 9 logistic low creatinine clearance vs normal creatinine clearance 5 00001632 140 rs1765618 125 5 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00001633 078 rs4673727 195 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00001634 154 rs592228 243 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 1 00001634 067 rs6925350 164 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001635 137 rs17411195 105 9 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 1 00001637 074 rs17042372 41 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00001638 154

rs4895849 123 5 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 6 00001638 069 rs2024055 147 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00001639 132 rs6913865 145 8 logistic low creatinine clearance vs normal creatinine clearance 6 0000164 189 rs4663163 245 2 logistic macroalbuminuria vs no albuminuria (at entry) 2 0000164 154 rs4790200 10 9 logistic macroalbuminuria vs no albuminuria (at entry) 17 0000164 217 rs485056 243 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 0000164 067 rs11652482 54 1 logistic macroalbuminuria vs no albuminuria (at entry) 17 00001641 154 rs11130850 81 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 3 00001644 151 rs763591 80 3 logistic low glomerular titration rate vs control (at entry) 16 00001645 152 rs16960210 450 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 15 00001647 139 rs2053158 101 5 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 17 00001648 155 rs7236575 69 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00001648 160 rs2699365 131 7 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00001649 072 rs4901755 62 3 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 14 00001649 133 rs260011 95 5 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 00001649 240 rs6831793 198 5 logistic low glomerular fitration rate vs control (follow-up) 4 00001649 151 rs11810706 191 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00001651 134 rs162079 69 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 20 00001652 151 rs1647966 137 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00001653 076 rs1241940 91 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 00001654 159 rs8080918 106 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 17 00001655 049 rs7557611 164 3 logistic microalbuminuria vs no albuminuria (at entry) 2 00001656 134 rs41454946 22 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00001657 060 rs841613 48 0 logistic low creatinine clearance vs normal creatinine clearance 12 00001658 061 rs183117 67 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 8 00001658 080 rs829584 48 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00001658 069 rs1351887 105 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 18 00001659 045 rs6669798 75 1 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 0000166 071 rs16825771 226 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 0000166 073 rs7251213 33 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 19 0000166 133 rs4925109 45 0 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 17 00001661 139 rs10922204 204 5 logistic low glomerular fitration rate vs control (at entry) 1 00001661 307 rs2607073 105 9 logistic low creatinine clearance vs normal creatinine clearance 8 00001661 148 rs10231343 66 3 logistic microalbuminuria vs no albuminuria (at entry) 7 00001661 138 rs6037908 12 4 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 20 00001662 143 rs17674649 42 7 logistic macroalbuminuria vs no albuminuria (at entry) 2 00001662 064 rs10142154 37 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 00001662 072 rs2135518 77 0 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 18 00001663 149 rs7237496 87 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00001664 071 rs4796354 13 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 17 00001665 132

rs10254929 663 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00001665 138 rs10496309 106 2 logistic albuminuria vs no albuminuria (follow-up) 2 00001668 068 rs996091 80 3 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00001669 073 rs6926642 166 6 logistic microalbuminuria or microalbuminuria vs control (at entry) 6 00001669 073 rs5752554 27 8 logistic low glomerular fitration rate vs control (follow-up) 22 0000167 038 rs6429453 275 7 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00001671 145 rs9834708 112 2 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00001673 069 rs7672620 77 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00001673 145 rs7696553 77 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00001673 145 rs2730306 20 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 00001673 165 rs10748721 1204 logistic low glomerular fitration rate vs control (follow-up) 10 00001677 067 rs2743979 9 9 logistic low glomerular fitration rate vs control (at entry) 1 00001679 067 rs6102795 57 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 0000168 069 rs12604327 87 2 logistic low creatinine clearance vs normal creatinine clearance 18 0000168 072 rs5003737 122 4 logistic low creatinine clearance vs normal creatinine clearance 9 0000168 071 rs2962615 5 9 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00001681 130 rs485056 243 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 1 00001682 067 rs2699365 131 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 00001683 065 rs17709552 62 2 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 11 00001684 062 rs1636307 35 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 7 00001685 075

Ul Ul rs10076 45 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00001685 234 rs7035425 83 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 9 00001685 129 rs1363697 163 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00001686 074 rs17594665 76 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00001686 044 rs2348914 141 1 logistic microalbuminuria vs no albuminuria (at entry) 7 00001687 149 rs11243150 11 4 logistic albuminuria vs no albuminuria (follow-up) 6 00001689 130 rs16848600 191 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00001689 038 rs7748736 11 5 logistic microalbuminuria vs no albuminuria (at entry) 6 00001689 132 rs17134277 108 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00001691 210 rs629222 239 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 00001692 147 rs11109197 102 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00001694 141 rs902891 159 6 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 12 00001694 135 rs2185427 102 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00001695 132 rs4861945 183 2 logistic low creatinine clearance vs normal creatinine clearance 4 00001695 153 rs448666 60 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 00001695 058 rs12586449 22 9 logistic low glomerular fitration rate vs control (follow-up) 14 00001698 153 rs1663501 23 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 21 00001698 126 rs7229063 109 3 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 000017 140 rs1529289 131 7 logistic low glomerular fitration rate vs control (follow-up) 2 000017 067 rs17568979 72 7 logistic low creatinine clearance vs normal creatinine clearance 2 000017 172

rs1610562 297 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00001701 057 rs32058 159 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00001703 132 rs2000833 87 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00001703 070 rs166412 119 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 00001703 064 rs6553089 204 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 4 00001704 079 rs10969027 52 6 logistic low creatinine clearance vs normal creatinine clearance 9 00001705 070 rs10787476 132 0 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00001707 181 rs8080918 106 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 17 00001707 049 rs6595512 131 3 logistic albuminuria vs no albuminuria (follow-up) 5 00001708 133 rs922554 131 3 logistic albuminuria vs no albuminuria (follow-up) 5 00001708 133 rs922553 131 3 logistic albuminuria vs no albuminuria (follow-up) 5 00001708 133 rs922552 131 3 logistic albuminuria vs no albuminuria (follow-up) 5 00001708 133 rs7705236 131 3 logistic albuminuria vs no albuminuria (follow-up) 5 00001708 133 rs7559074 90 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00001708 144 rs7832582 102 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 0000171 057 rs3912537 79 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00001713 146 rs7203172 48 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00001713 054 rs8083437 87 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00001714 073 rs2592115 239 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00001715 153 rs3750595 120 4 logistic low glomerular fitration rate vs control (follow-up) 10 00001716 067

Os rs4964292 112 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 12 00001716 211 rs7832582 102 1 logistic albuminuria vs no albuminuria (follow-up) 8 00001716 057 rs10867195 78 3 logistic macroalbuminuria vs no albuminuria (at entry) 9 00001717 206 rs2267889 120 7 logistic low glomerular fitration rate vs control (follow-up) 7 00001718 039 rs7637853 152 6 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 3 00001719 064 rs7246997 37 7 logistic low creatinine clearance vs normal creatinine clearance 19 00001719 140 rs6883415 164 1 logistic macroalbuminuria vs no albuminuria (at entry) 5 00001719 182 rs4609433 240 0 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 1 0000172 076 rs485056 243 5 logistic GE ₁ AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 1 0000172 067 rs2789417 166 4 logistic microalbuminuria vs no albuminuria (at entry) 1 0000172 058 rs12595945 65 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 00001721 068 rs7501838 63 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 17 00001722 212 rs10817737 103 6 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 9 00001723 073 rs10786405 120 4 logistic low glomerular fitration rate vs control (follow-up) 10 00001723 066 rs10233697 66 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00001723 141 rs9364534 164 4 logistic albuminuria vs no albuminuria (at entry) 6 00001724 138 rs448666 60 8 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00001726 058 rs4663163 245 2 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00001727 154 rs2699365 131 7 logistic low creatinine clearance vs normal creatinine clearance 2 00001728 071 rs10845092 204 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00001728 023

rs1653782 44 4 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 2 00001729 177 rs8064088 85 1 logistic low creatinine clearance vs normal creatinine clearance 16 0000173 173 rs2631046 72 3 logistic AGE, SEX low glomerular titration rate vs control (at entry) 4 00001731 154 rs4901755 62 3 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 14 00001734 133 rs11243149 11 4 logistic albuminuria vs no albuminuria (follow-up) 6 00001734 130 rs16848171 186 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00001736 053 rs11648875 104 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 16 00001736 171 rs221035 35 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00001736 070 rs10234057 66 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00001737 140 rs10153433 72 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00001738 074 rs1653782 44 4 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 2 00001739 177 rs17154065 35 2 logistic AGE, SEX low glomerular titration rate vs control (at entry) 10 0000174 142 rs3909788 125 5 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 12 00001741 073 rs12485415 42 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00001742 209 rs7705409 131 3 logistic albuminuria vs no albuminuria (follow-up) 5 00001744 133 rs12599351 124 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 16 00001746 075 rs1416079 113 1 logistic albuminuria vs no albuminuria (at entry) 1 00001747 161 rs10792617 84 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00001747 135 rs2654981 112 4 logistic albuminuria vs no albuminuria (at entry) 15 00001749 077 rs2115198 53 2 logistic albuminuria vs no albuminuria (follow-up) 5 00001749 075 rs4580841 82 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 00001751 076 rs1653782 44 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00001752 178 rs2035187 78 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 4 00001753 050 rs17594526 76 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00001754 044 rs11146456 172 9 logistic low creatinine clearance vs normal creatinine clearance 10 00001756 160 rs130250 31 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 22 00001756 070 rs6567316 94 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 18 00001758 049 rs34266279 130 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 7 00001758 207 rs221035 35 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00001758 070 rs4659819 258 8 logistic albuminuria vs no albuminuria (follow-up) 1 00001759 078 rs2066926 28 6 logistic low glomerular titration rate vs control (follow-up) 22 00001762 170 rs10077522 129 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 5 00001762 140 rs470455 52 5 logistic albuminuria vs no albuminuria (at entry) 18 00001763 076 rs2604628 72 3 logistic AGE, SEX low glomerular titration rate vs control (at entry) 4 00001765 153 rs1986877 55 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00001766 074 rs11586374 208 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00001766 159 rs16854563 212 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 00001767 152 rs260005 95 5 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 20 00001768 228 rs17036537 71 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00001768 061 rs10248275 5 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 7 0000177 182

rs11810706 191 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 00001773 139 rs4378283 82 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 10 00001775 034 rs17021710 146 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00001776 032 rs11853308 6 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 15 00001777 073 rs11224427 98 2 logistic macroalbuminuria vs no albuminuria (at entry) 11 00001778 356 rs9325744 30 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 8 0000178 151 rs13240269 664 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00001781 140 rs2738078 9 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 8 00001781 066 rs1028050 73 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 11 00001782 194 rs10514479 104 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 16 00001782 192 rs2115198 53 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00001782 075 rs9853784 122 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 00001783 129 rs748165 90 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 10 00001784 132 rs3112857 198 8 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00001784 141 rs16953054 74 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 17 00001784 155 rs12795565 15 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 11 00001784 061 rs12120173 243 1 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00001785 139 rs1477437 28 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 15 00001786 183 rs1530104 131 7 logistic low glomerular fitration rate vs control (follow-up) 2 00001786 067 rs4236836 107 4 logistic albuminuria vs no albuminuria (follow-up) 8 00001786 131

OO rs2401841 100 0 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 00001786 134 rs10493131 75 1 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00001788 071 rs2789417 166 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00001788 058 rs2024055 147 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 0000179 132 rs11688740 80 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 0000179 157 rs2220521 172 8 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00001791 059 rs11168421 63 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00001791 130 rs16901597 138 2 logistic low creatinine clearance vs normal creatinine clearance 8 00001792 245 rs2962792 41 1 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 00001792 055 rs12485415 42 4 logistic microalbuminuria vs no albuminuria (at entry) 3 00001793 205 rs2844032 60 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00001794 059 rs1558531 17 0 logistic albuminuria vs no albuminuria (follow-up) 12 00001795 053 rs11109197 102 8 logistic albuminuria vs no albuminuria (follow-up) 12 00001795 141 rs10889155 88 9 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 00001796 144 rs7967892 58 8 logistic albuminuria vs no albuminuria (at entry) 12 00001796 130 rs3910183 149 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 5 00001797 167 rs7967892 58 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 12 00001797 130 rs17365438 72 9 logistic low creatinine clearance vs normal creatinine clearance 15 00001797 158 rs16901596 138 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 8 00001797 254 rs1510294 123 7 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 6 00001798 135

rs11118204 239 1 logistic AGE, SEX low glomerular titration rate vs control (at entry) 1 00001799 159 rs9309981 112 0 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 3 00001801 072 rs16825731 186 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00001801 053 rs4936167 141 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00001802 048 rs9457730 164 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00001803 138 rs2547353 103 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 19 00001804 032 rs1224674 45 0 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 15 00001807 068 rs3912537 79 3 logistic albuminuria vs no albuminuria (follow-up) 8 00001807 146 rs10231343 66 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00001808 138 rs1653782 44 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00001809 178 rs7202791 67 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 16 0000181 130 rs12599351 124 5 logistic microalbuminuria vs no albuminuria (at entry) 16 00001811 075 rs1441511 32 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00001812 070 rs6997147 96 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00001813 078 rs12485415 42 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 00001813 205 rs16889712 124 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 8 00001813 163 rs12895787 91 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 14 00001814 154 rs11803988 288 4 logistic low glomerular fitration rate vs control (at entry) 1 00001815 169 rs4387746 170 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 2 00001815 143 rs3917786 187 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00001815 076 rs11082650 68 2 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00001816 067 rs17680407 43 3 logistic low glomerular fitration rate vs control (at entry) 4 00001817 063 rs4661539 33 5 logistic macroalbuminuria vs no albuminuria (at entry) 1 00001817 064 rs7646681 119 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00001818 172 rs10751020 84 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00001818 075 rs476179 62 9 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 13 00001819 075 rs552643 62 9 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 13 00001819 075 rs507529 62 9 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 13 00001819 075 rs1860192 11 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 19 00001819 142 rs16825771 226 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 2 00001819 073 rs7972260 143 9 logistic low glomerular fitration rate vs control (at entry) 12 0000182 153 rs4440442 82 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 0000182 075 rs2127546 78 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 0000182 075 rs9502593 11 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001821 129 rs9634205 96 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00001821 074 rs11150225 104 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 16 00001822 147 rs1361196 113 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00001822 202 rs1416078 113 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00001822 202 rs10254929 66 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00001822 138 rs17029949 13 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00001823 273

rs4924481 38 4 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 15 00001824 133 rs2024055 147 8 logistic albuminuria vs no albuminuria (at entry) 5 00001824 132 rs1998617 92 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00001824 149 rs2401841 100 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 14 00001825 132 rs16901597 138 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 8 00001825 245 rs7895452 294 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 10 00001829 064 rs7611991 112 2 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 3 00001832 072 rs16973718 45 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 16 00001832 191 rs4661539 33 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00001834 064 rs1647966 137 3 logistic albuminuria vs no albuminuria (at entry) 11 00001835 076 rs12055256 130 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00001835 149 rs661609 83 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00001836 143 rs1541749 8 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 00001839 069 rs6472346 83 6 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 8 0000184 053 rs1258241 69 7 logistic low glomerular titration rate vs control (at entry) 10 0000184 068 rs10231343 66 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 0000184 138 rs9420501 102 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 10 0000184 135 rs17042372 41 7 logistic microalbuminuria vs no albuminuria (at entry) 3 0000184 154 rs16901596 138 2 logistic GE ₁ AGE ₁ SEX low creatinine clearance vs normal creatinine clearance 8 00001842 254 rs9675700 87 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00001843 071 o rs10070326 8 0 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00001843 269 rs4334629 41 8 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 3 00001844 074 rs8056052 67 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 16 00001844 135 rs17171382 141 4 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 5 00001845 151 rs16931308 81 2 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 8 00001848 205 rs1514417 17 9 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 21 00001849 160 rs13110738 124 4 logistic low creatinine clearance vs normal creatinine clearance 4 0000185 151 rs2826684 14 1 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 21 00001852 140 rs10751020 84 3 logistic albuminuria vs no albuminuria (at entry) 11 00001853 077 rs17509991 76 8 logistic albuminuria vs no albuminuria (follow-up) 18 00001853 044 rs2677810 251 3 logistic low glomerular titration rate vs control (follow-up) 1 00001854 147 rs1836847 37 5 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 15 00001856 047 rs1966909 103 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00001856 062 rs10736593 137 3 logistic AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 11 00001856 074 rs12956604 109 3 logistic low glomerular titration rate vs control (at entry) 18 00001858 148 rs1402337 134 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 00001858 144 rs7492012 27 7 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 13 00001859 137 rs2000833 87 2 logistic AGE ₁ SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 18 00001859 073 rs1254947 149 2 logistic microalbuminuria vs no albuminuria (at entry) 10 00001859 132 rs12258211 81 8 logistic microalbuminuria vs no albuminuria (at entry) 10 00001859 159

rs1541749 8 5 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 8 00001859 069 rs9317560 50 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00001859 072 rs2502845 191 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00001859 138 rs12882375 44 0 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 14 0000186 055 rs17487422 38 5 logistic albuminuria vs no albuminuria (follow-up) 14 0000186 143 rs1114418 137 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 0000186 074 rs9457730 164 6 logistic microalbuminuria vs no albuminuria (at entry) 6 0000186 138 rs11857247 38 4 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 15 00001862 136 rs4279411 166 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 00001862 074 rs158688 97 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 9 00001862 072 rs10495598 29 2 logistic albuminuria vs no albuminuria (follow-up) 2 00001863 139 rs4900914 52 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 14 00001863 135 rs9502593 11 5 logistic microalbuminuria vs no albuminuria (at entry) 6 00001863 131 rs448666 60 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00001865 063 rs10873499 122 6 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 14 00001866 192 rs2829583 19 9 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 21 00001866 179 rs9390961 103 2 logistic low creatinine clearance vs normal creatinine clearance 6 00001868 155 rs592228 243 5 logistic microalbuminuria vs no albuminuria (at entry) 1 00001868 067 rs2730306 20 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00001868 192 rs16854563 212 7 logistic albuminuria vs no albuminuria (at entry) 2 00001869 152 rs1114418 137 3 logistic microalbuminuria vs no albuminuria (at entry) 11 00001869 074 rs10070326 8 0 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 5 0000187 237 rs 11259272 18 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 10 00001871 150 rs12710732 40 0 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 2 00001873 073 rs2858638 61 6 logistic albuminuria vs no albuminuria (at entry) 22 00001874 069 rs2730306 20 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 3 00001874 165 rs1118433 87 4 logistic low creatinine clearance vs normal creatinine clearance 18 00001874 072 rs225549 146 9 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 12 00001875 064 rs9394187 46 7 logistic GE ₁ AGE, SEX low glomerular titration rate vs control (at entry) 6 00001876 073 rs1545741 93 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00001876 233 rs12188581 147 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00001877 132 rs17345528 117 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00001877 134 rs4266861 208 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00001877 159 rs6676401 244 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 1 00001879 222 rs17492851 147 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 0000188 132 rs7695033 95 2 logistic low glomerular titration rate vs control (at entry) 4 00001883 209 rs10736593 137 3 logistic microalbuminuria vs no albuminuria (at entry) 11 00001883 074 rs2024447 67 2 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 00001884 130 rs1022377 42 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00001884 064 rs11129937 67 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00001884 075

rs2831543 25 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 21 00001884 071 rs11640993 67 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 16 00001886 139 rs11243150 11 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00001886 130 rs16956216 33 8 logistic macroalbuminuria vs no albuminuria (at entry) 18 00001886 226 rs2368053 101 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00001888 066 rs1908329 71 9 logistic microalbuminuria vs no albuminuria (at entry) 12 00001889 133 rs2962792 41 1 logistic microalbuminuria vs no albuminuria (at entry) 5 00001889 055 rs731017 151 1 logistic low glomerular fitration rate vs control (follow-up) 1 0000189 151 rs965574 151 1 logistic low glomerular fitration rate vs control (follow-up) 1 0000189 151 rs4133295 175 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00001892 130 rs6552719 192 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00001892 141 rs1396512 63 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 00001892 161 rs17076524 145 7 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 6 00001893 157 rs16893391 90 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 6 00001894 051 rs16968126 91 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00001894 189 rs1477437 28 5 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 15 00001895 183 rs16893391 90 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 6 00001895 051 rs1647786 56 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00001896 066 rs2292927 159 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 00001898 141 rs2539831 117 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00001898 128 rs4761756 97 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 12 000019 078 rs17791802 3 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 000019 056 rs17600042 108 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 000019 050 rs2444242 116 2 logistic low glomerular fitration rate vs control (at entry) 11 00001903 206 rs12485415 42 4 logistic albuminuria vs no albuminuria (follow-up) 3 00001903 209 rs13276054 46 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 8 00001903 070 rs17791802 3 0 logistic macroalbuminuria vs no albuminuria (at entry) 7 00001904 056 rs10070326 8 0 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00001905 269 rs4323877 145 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 11 00001907 183 rs6809087 41 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00001907 133 rs16825771 226 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 00001908 069 rs10495598 29 2 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 2 00001908 155 rs11243149 11 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00001911 130 rs2683690 85 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 00001912 139 rs1161262 95 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 00001913 165 rs2921571 12 8 logistic low glomerular fitration rate vs control (at entry) 5 00001914 172 rs4940957 87 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00001915 073 rs11060924 163 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 00001915 049 rs841613 48 0 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 12 00001916 064 rs9426484 10 0 logistic low glomerular fitration rate vs control (at entry) 1 00001916 068

rs9502593 11 5 logistic albuminuria vs no albuminuria (at entry) 6 00001917 129 rs7913419 34 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 10 00001917 078 rs1726392 133 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00001918 126 rs11609178 94 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 00001918 196 rs1493902 71 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00001918 148 rs1258246 69 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 10 00001919 066 rs4900914 52 0 logistic albuminuria vs no albuminuria (follow-up) 14 00001919 135 rs1258246 69 8 logistic low glomerular fitration rate vs control (at entry) 10 0000192 068 rs9457730 164 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00001921 138 rs9502593 11 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00001922 131 rs11223077 141 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00001923 047 rs1489922 172 8 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00001924 060 rs4535211 41 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00001925 132 rs4923876 38 4 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 15 00001926 132 rs10816424 112 5 logistic low creatinine clearance vs normal creatinine clearance 9 00001927 159 rs2829583 19 9 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 21 00001928 179 rs17022224 59 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00001928 203 rs341081 73 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 11 00001929 184 rs5010979 10 2 logistic microalbuminuria vs no albuminuria (at entry) 11 00001929 071 rs2602707 17 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 19 0000193 190 rs11135724 46 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 0000193 070 rs10765796 93 3 logistic albuminuria vs no albuminuria (at entry) 11 00001931 078 rs17818395 74 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 17 00001932 070 rs1378500 117 1 logistic macroalbuminuria vs no albuminuria (at entry) 5 00001932 181 rs922556 131 3 logistic albuminuria vs no albuminuria (follow-up) 5 00001934 133 rs8099832 87 2 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00001935 074 rs13153675 147 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00001935 132 rs1918026 63 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00001935 138 rs2147102 55 4 logistic low glomerular fitration rate vs control (follow-up) 14 00001936 066 rs1616442 69 9 logistic low creatinine clearance vs normal creatinine clearance 18 00001936 056 rs2419950 37 7 logistic low creatinine clearance vs normal creatinine clearance 19 00001936 072 rs6472346 83 6 logistic low glomerular fitration rate vs control (at entry) 8 00001937 051 rs2025445 116 7 logistic albuminuria vs no albuminuria (at entry) 10 00001938 073 rs4424038 156 7 logistic microalbuminuria vs no albuminuria (at entry) 5 00001938 138 rs4569270 110 9 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 0000194 142 rs1416078 113 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00001941 159 rs10742654 53 6 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 00001941 155 rs2025445 116 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 10 00001943 073 rs8071834 45 4 logistic albuminuria vs no albuminuria (follow-up) 17 00001946 078 rs11842662 45 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00001946 235

rs11720604 90 4 logistic low glomerular titration rate vs control (at entry) 3 0000195 183 rs10748721 120 4 logistic low glomerular Titration rate vs control (at entry) 10 00001952 067 rs12973797 58 8 logistic AGE, SEX low glomerular titration rate vs control (at entry) 19 00001952 064 rs1678030 130 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 14 00001952 061 rs8071834 454 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 17 00001953 078 rs10749578 102 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00001954 135 rs11024875 22 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 11 00001954 062 rs2447196 40 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 15 00001955 145 rs17272796 41 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00001955 132 rs17258731 146 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 00001957 156 rs4805218 49 9 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 19 00001958 074 rs17709552 62 2 logistic low glomerular fitration rate vs control (at entry) 11 00001958 053 rs1161263 95 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00001959 216 rs10867190 78 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 00001959 202 rs10735253 94 1 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 0000196 191 rs2359630 16 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 4 00001961 132 rs2646261 252 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 00001962 150 rs1545074 131 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00001963 143 rs11648875 104 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 00001963 171 rs4643164 95 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 13 00001964 076 rs6497089 96 θ logistic microalbuminuria or macroalbuminuria vs control (follow-up) 15 00001964 035 rs957582 77 5 logistic low glomerular fitration rate vs control (follow-up) 4 00001965 185 rs9908767 44 1 logistic albuminuria vs no albuminuria (follow-up) 17 00001966 073 rs6693866 288 4 logistic low glomerular fitration rate vs control (at entry) 1 00001967 168 rs17076442 145 7 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 6 00001969 197 rs2812657 62 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 10 00001969 141 rs7035425 83 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 9 00001971 129 rs8103254 103 0 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 19 00001973 151 rs10973581 0 9 logistic HBP ₁ diabetes duration microalbuminuria vs no albuminuria (at entry) 9 00001976 077 rs1371225 72 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 4 00001977 264 rs10892549 116 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 11 00001977 068 rs10765796 93 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00001977 078 rs10736593 137 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00001979 074 rs4535211 41 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 0000198 135 rs4406411 101 8 logistic low glomerular fitration rate vs control (at entry) 8 00001981 147 rs1998617 92 7 logistic microalbuminuria or macroalbuminuria vs controf (at entry) 6 00001981 149 rs2046535 198 3 logistic low glomerular fitration rate vs control (at entry) 4 00001983 147 rs645170 34 6 logistic low glomerular fitration rate vs control (follow-up) 19 00001983 182 rs1356952 134 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00001983 139 rs1529579 117 9 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00001985 069

rs1402337 134 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00001986 139 rs10111251 106 2 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00001986 052 rs11931592 55 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00001986 140 rs10786405 1204 logistic low glomerular fitration rate vs control (at entry) 10 00001989 067 rs17594665 76 8 logistic albuminuria vs no albuminuria (follow-up) 18 00001989 044 rs7648466 69 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00001989 076 rs10790444 117 9 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00001991 070 rs1452420 38 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00001992 149 rs2895647 147 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00001992 132 rs6669798 75 1 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00001994 071 rs7926119 53 6 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 00001994 154 rs2623770 95 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00001995 197 rs292069 43 4 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00001997 067 rs748165 90 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00001997 132 rs4909954 16 9 logistic low creatinine clearance vs normal creatinine clearance 11 00001997 159 rs1455593 101 1 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00001997 056 rs16825798 186 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00001997 055 rs6037908 12 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 20 00001998 138 rs2137997 84 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 11 00001999 154 rs10897973 84 9 logistic GE ₁ AGE, SEX low glomerular fitration rate vs control (at entry) 11 00001999 154 en rs12508383 131 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00001999 142 rs1510699 43 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00002001 078 rs9872164 90 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00002001 068 rs10803476 31 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00002001 069 rs2675967 239 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00002003 146 rs4688828 144 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00002004 060 rs7841489 125 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 8 00002006 057 rs6488711 31 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00002008 068 rs7691652 114 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00002009 064 rs17594526 76 8 logistic albuminuria vs no albuminuria (follow-up) 18 00002009 044 rs6546797 90 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00002009 140 rs17801910 78 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00002011 197 rs17492851 147 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002013 132 rs12188581 147 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002013 132 rs4936618 117 8 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00002014 069 rs2934467 121 5 logistic low glomerular fitration rate vs control (follow-up) 16 00002015 147 rs10914220 59 9 logistic albuminuria vs no albuminuria (follow-up) 1 00002015 145 rs1331484 0 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00002016 135 rs3750595 120 4 logistic low glomerular fitration rate vs control (at entry) 10 00002017 067 rs4985702 44 2 logistic albuminuria vs no albuminuria (follow-up) 17 00002018 073

rs7334517 40 0 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 13 00002018 063 rs10071774 68 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 0000202 066 rs11951359 68 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 0000202 066 rs512421 664 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 11 0000202 139 rs17071960 45 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 13 0000202 234 rs16851268 216 8 logistic microalbuminuria vs no albuminuria (at entry) 1 0000202 067 rs17042372 41 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 3 00002021 149 rs2502845 191 8 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 1 00002021 138 rs11168421 63 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00002022 127 rs157352 159 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00002022 129 rs12959290 26 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 18 00002025 139 rs592228 243 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 1 00002025 067 rs10166160 170 2 logistic albuminuria vs no albuminuria (at entry) 2 00002027 144 rs28891 130 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 5 00002027 162 rs10153433 72 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00002028 074 rs17345528 117 4 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (at entry) 3 00002029 131 rs10914220 59 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00002029 145 rs9487891 118 6 logistic albuminuria vs no albuminuria (follow-up) 6 0000203 060 rs10248275 5 3 logistic albuminuria vs no albuminuria (at entry) 7 00002031 182 rs7624432 190 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00002031 226 rs11118204 239 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 1 00002032 159 rs16957020 39 9 logistic AGE ₁ SEX low glomerular fitration rate vs control (follow-up) 15 00002034 141 rs13153675 147 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002034 132 rs12446492 39 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 16 00002035 063 rs2090018 44 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 17 00002036 074 rs344708 28 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 5 00002037 067 rs603151 26 3 logistic low creatinine clearance vs normal creatinine clearance 1 00002037 143 rs10259377 66 3 logistic microalbuminuria vs no albuminuria (at entry) 7 00002037 138 rs7973993 112 5 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00002038 198 rs1966908 103 3 logistic AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 2 00002039 062 rs2960744 151 1 logistic low glomerular fitration rate vs control (at entry) 7 0000204 067 rs9309981 112 0 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00002041 072 rs1558531 17 0 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 12 00002041 053 rs9939736 125 8 logistic GE ₁ AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 00002041 072 rs17492851 147 8 logistic albuminuria vs no albuminuria (at entry) 5 00002045 132 rs12188581 147 8 logistic albuminuria vs no albuminuria (at entry) 5 00002045 132 rs2839580 49 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 21 00002045 078 rs4341081 151 1 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00002045 073 rs17641512 40 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00002045 063 rs7964939 82 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00002045 063

rs10495829 53 5 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 2 00002047 302 rs7188142 80 2 logistic low glomerular Titration rate vs control (follow-up) 16 00002048 153 rs1114418 137 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00002049 076 rs4789193 101 5 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 17 00002049 153 rs1114418 137 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00002049 074 rs12446492 39 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00002049 073 rs10079980 97 3 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 5 00002051 139 rs1239771 125 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00002051 075 rs13438289 147 5 logistic AGE, SEX low glomerular Titration rate vs normal glom filtration rate (follow-up) 7 00002052 138 rs7185053 27 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 16 00002052 071 rs7895452 29 4 logistic macroalbuminuria vs no albuminuria (at entry) 10 00002056 064 rs9872164 90 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00002056 067 rs4895849 123 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 6 00002057 069 rs17233934 69 3 logistic low glomerular titration rate vs control (follow-up) 7 00002058 246 rs2934467 121 5 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 16 00002058 147 rs354391 81 8 logistic albuminuria vs no albuminuria (follow-up) 6 00002058 075 rs2730306 20 0 logistic albuminuria vs no albuminuria (at entry) 3 0000206 165 rs1396247 56 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00002061 134 rs1022377 42 6 logistic macroalbuminuria vs no albuminuria (at entry) 2 00002061 064 rs4341081 151 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 7 00002062 073 rs7621243 42 1 logistic albuminuria vs no albuminuria (at entry) 3 00002063 067 rs8071834 454 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 17 00002063 078 rs10238177 90 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00002063 133 rs922555 131 3 logistic albuminuria vs no albuminuria (follow-up) 5 00002064 132 rs1908329 71 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00002064 133 rs1382394 87 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00002065 072 rs3024676 52 4 logistic low glomerular titration rate vs control (follow-up) 16 00002067 059 rs9843093 119 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00002068 172 rs6673013 208 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00002069 142 rs962316 126 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 0000207 135 rs12527030 175 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 0000207 077 rs831663 28 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 00002072 188 rs3790659 177 5 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00002073 132 rs157676 159 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00002073 129 rs 10978606 112 5 logistic low creatinine clearance vs normal creatinine clearance 9 00002075 158 rs304215 84 4 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 3 00002076 072 rs11131154 29 4 logistic low creatinine clearance vs normal creatinine clearance 3 00002076 052 rs9332066 45 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00002077 228 rs7621243 42 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 3 00002078 067 rs12599351 124 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 16 00002078 076

rs7185053 27 3 logistic albuminuria vs no albuminuria (at entry) 16 00002079 071 rs10845092 204 logistic AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 12 00002079 023 rs17824261 20 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 0000208 028 rs11707973 152 6 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 3 00002081 066 rs5010979 10 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00002081 071 rs12932741 121 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 16 00002082 074 rs7203172 48 8 logistic microalbuminuria vs no albuminuria (at entry) 16 00002083 062 rs617595 59 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 13 00002083 152 rs226799 69 9 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 20 00002084 076 rs7611310 130 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 00002084 128 rs7765427 91 2 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 6 00002085 149 rs7567280 186 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 2 00002087 073 rs1647966 137 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00002088 076 rs16851268 216 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00002088 067 rs807525 41 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 6 00002088 060 rs13240269 66 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00002089 140 rs17042372 41 7 logistic albuminuria vs no albuminuria (at entry) 3 00002091 149 rs1466122 48 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00002091 078 rs2481628 191 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00002091 139 rs2829276 19 7 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 21 00002091 136 rs2631041 72 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 4 00002092 150 rs2964003 156 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 5 00002092 151 rs10874849 125 5 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00002093 078 rs645170 34 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 19 00002093 183 rs7185053 27 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00002095 067 rs2142090 43 7 logistic GE, AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 21 00002099 150 rs7690478 57 3 logistic low glomerular fitration rate vs control (follow-up) 4 000021 156 rs2596586 32 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 8 000021 124 rs4799011 121 4 logistic macroalbuminuria vs no albuminuria (at entry) 18 00002101 180 rs4656799 188 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00002103 141 rs10743140 15 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00002104 056 rs9487891 118 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00002104 060 rs10786968 126 7 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00002106 142 rs1054497 174 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00002107 126 rs6831793 198 5 logistic low glomerular fitration rate vs control (at entry) 4 0000211 148 rs194782 74 2 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 14 0000211 151 rs3809485 45 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 15 00002111 078 rs12301748 17 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00002111 058 rs10788901 75 6 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 1 00002113 062 rs10867195 78 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 00002113 206

rs4490884 0 7 logistic low glomerular titration rate vs control (at entry) 8 00002114 056 rs949229 41 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002114 144 rs2327267 26 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 20 00002115 065 rs9592445 50 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00002115 073 rs2930629 6 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 15 00002116 073 rs12775879 132 0 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00002117 177 rs2344863 80 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 15 00002117 136 rs7985116 86 0 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 13 00002119 073 rs1416078 113 1 logistic albuminuria vs no albuminuria (at entry) 1 00002119 159 rs1764844 239 1 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 1 00002121 148 rs12953319 87 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00002121 073 rs2831543 25 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 21 00002121 071 rs1687970 125 5 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 1 00002122 078 rs4118375 210 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00002122 071 rs1013685 19 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00002122 076 rs4799011 121 4 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 18 00002124 180 rs7838420 79 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00002125 145 rs4609433 240 0 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00002125 076 rs1161263 95 2 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 4 00002126 165 rs2895647 147 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002126 132 rs162079 69 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 20 00002126 151 rs7908698 125 6 logistic low glomerular titration rate vs control (follow-up) 10 00002127 039 rs10233697 66 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00002127 141 rs1908329 71 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00002128 133 rs10495444 262 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00002129 131 rs4422395 81 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 4 00002131 145 rs4905630 120 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 14 00002132 073 rs11648875 104 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00002132 156 rs11152369 76 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002133 040 rs17594665 76 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002133 040 rs1239771 125 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00002134 075 rs9686988 136 7 logistic macroalbuminuria vs no albuminuria (at entry) 5 00002135 059 rs4701434 37 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 00002135 143 rs983860 129 2 logistic AGE, SEX low glomerular titration rate vs control (at entry) 7 00002136 142 rs12127748 204 5 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 1 00002137 221 rs7303573 58 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 12 00002137 131 rs7808966 180 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 7 00002137 079 rs13153675 147 8 logistic albuminuria vs no albuminuria (at entry) 5 00002138 132 rs4243177 104 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00002139 137 rs4573006 59 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 0000214 073

rs7567280 186 0 logistic microalbuminuria or macroalbuminuπa vs control (follow-up) 2 0000214 073 rs7303573 58 5 logistic albuminuria vs no albuminuria (at entry) 12 00002141 131 rs17101871 133 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 14 00002141 145 rs17779263 95 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 17 00002143 178 rs470455 52 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 18 00002144 076 rs1123025 54 0 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 17 00002144 128 rs2471533 94 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00002147 064 rs2699367 131 7 logistic low glomerular fitration rate vs control (follow-up) 2 00002148 067 rs17509991 76 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002148 040 rs6809087 41 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00002149 135 rs2895647 147 8 logistic albuminuria vs no albuminuria (at entry) 5 0000215 132 rs4321205 38 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00002151 073 rs4280249 38 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00002151 073 rs4369676 38 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00002151 073 rs10114374 102 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 9 00002152 131 rs10982727 123 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 00002152 163 rs2158951 664 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00002153 139 rs7281608 17 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 21 00002153 151 rs9424612 248 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00002154 064 rs1477437 28 5 logistic low glomerular fitration rate vs control (at entry) 15 00002155 183

O rs17042372 41 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 00002155 149 rs34266279 130 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00002155 207 rs10493131 75 1 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00002156 071 rs5010979 10 2 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00002156 071 rs1483737 101 9 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 4 00002157 153 rs408510 71 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 0000216 068 rs2383957 94 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 0000216 139 rs12775879 132 0 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 10 00002161 177 rs13015251 78 4 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00002161 170 rs192598 111 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 16 00002162 076 rs12120893 127 4 logistic macroalbuminuria vs no albuminuria (at entry) 1 00002162 155 rs349447 71 8 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00002164 149 rs10758202 57 1 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 9 00002165 068 rs1035704 44 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 15 00002165 131 rs10845092 204 logistic microalbuminuria vs no albuminuria (at entry) 12 00002166 023 rs2826686 14 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 21 00002167 139 rs9317562 50 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00002168 072 rs2334063 4 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 7 0000217 077 rs2804085 45 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 13 0000217 236 rs12485415 42 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00002171 205

rs2937813 12 8 logistic low glomerular titration rate vs control (at entry) 5 00002173 171 rs2962792 41 1 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 00002174 055 rs17258731 146 1 logistic albuminuria vs no albuminuria (at entry) 6 00002176 156 rs2826681 14 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 21 00002176 140 rs2831543 25 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 21 00002178 071 rs908110 84 8 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 11 00002179 151 rs11897612 119 6 logistic low glomerular titration rate vs control (follow-up) 2 0000218 147 rs10188434 119 5 logistic low glomerular titration rate vs control (follow-up) 2 0000218 147 rs550523 26 3 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 1 00002181 140 rs2035219 29 3 logistic low creatinine clearance vs normal creatinine clearance 3 00002181 053 rs12944499 12 7 logistic AGE, SEX low glomerular titration rate vs control (at entry) 17 00002182 150 rs3852539 49 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 12 00002183 134 rs7908698 125 6 logistic low glomerular titration rate vs control (at entry) 10 00002184 037 rs1416079 113 1 logistic macroalbuminuria vs no albuminuria (at entry) 1 00002184 204 rs2383958 94 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00002185 139 rs4571397 66 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 4 00002185 138 rs11853308 6 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 15 00002185 073 rs829573 48 7 logistic low glomerular titration rate vs control (follow-up) 2 00002186 065 rs2730306 20 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00002186 220 rs17487529 46 2 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 9 00002187 138 rs10465473 248 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 1 00002187 078 rs10503257 5 1 logistic AGE, SEX low glomerular titration rate vs control (at entry) 8 00002188 145 rs12775879 132 0 logistic low creatinine clearance vs normal creatinine clearance 10 00002188 177 rs12796585 32 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00002188 071 rs2831491 25 7 logistic AGE, SEX low glomerular titration rate vs control (at entry) 21 0000219 079 rs17807662 117 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 0000219 045 rs6007450 52 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 22 00002191 062 rs6037908 12 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 20 00002193 138 rs17767946 46 7 logistic albuminuria vs no albuminuria (follow-up) 8 00002195 137 rs10759765 103 6 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00002198 074 rs7047148 78 3 logistic macroalbuminuria vs no albuminuria (at entry) 9 00002198 201 rs17233934 69 3 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 7 00002199 246 rs11152369 76 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00002199 043 rs4629927 15 0 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00002202 127 rs10043682 130 0 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 5 00002203 135 rs3809485 45 0 logistic albuminuria vs no albuminuria (at entry) 15 00002204 078 rs10788562 102 6 logistic albuminuria vs no albuminuria (follow-up) 10 00002204 130 rs809639 239 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00002204 145 rs11224427 98 2 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 00002205 356 rs9891294 74 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 17 00002206 154

rs910771 55 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 22 00002206 080 rs4775711 45 0 logistic macroalbuminuπa vs no albuminuria (at entry) 15 00002207 064 rs635409 103 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002207 049 rs12656061 130 8 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00002208 159 rs17673703 38 4 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 15 00002208 070 rs192598 111 1 logistic albuminuria vs no albuminuria (follow-up) 16 00002209 076 rs2710016 38 3 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 2 0000221 065 rs4661539 33 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 0000221 064 rs2826683 14 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 21 0000221 139 rs1292081 56 4 logistic low glomerular fitration rate vs control (at entry) 1 00002211 053 rs7709237 100 9 logistic low glomerular fitration rate vs control (at entry) 5 00002211 149 rs17099262 67 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 14 00002211 140 rs10956801 102 7 logistic microalbuminuria vs no albuminuria (at entry) 8 00002211 214 rs869346 91 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 14 00002213 164 rs16967971 56 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 19 00002214 199 rs1859875 66 3 logistic microalbuminuria vs no albuminuria (at entry) 7 00002215 137 rs9564847 53 0 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 13 00002216 050 rs2324614 37 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 13 00002218 069 rs9646596 76 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002218 039 rs9487891 118 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up)

-J 6 00002219 054

K) rs203948 66 7 logistic low glomerular fitration rate vs control (at entry) 8 00002221 058 rs10743140 15 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00002221 056 rs9364250 185 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 00002223 076 rs11150225 104 6 logistic albuminuria vs no albuminuria (follow-up) 16 00002223 147 rs162079 69 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 20 00002224 151 rs592228 243 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00002225 067 rs9325521 126 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00002226 143 rs7750426 166 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 00002227 073 rs7117210 93 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 11 00002228 073 rs1258323 69 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 10 0000223 068 rs11129937 67 0 logistic microalbuminuria vs no albuminuria (at entry) 3 0000223 075 rs1929751 59 2 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 0000223 062 rs729438 133 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 0000223 142 rs2035187 78 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 0000223 050 rs12492701 1704 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 3 00002231 074 rs7648466 69 6 logistic albuminuria vs no albuminuria (follow-up) 3 00002231 076 rs4701434 37 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00002231 143 rs3863992 158 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00002231 150 rs7072493 137 4 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 10 00002233 077 rs279259 35 0 logistic macroalbuminuria vs no albuminuria (at entry) 19 00002233 212

rs279257 35 0 logistic macroalbuminuria vs no albuminuria (at entry) 19 00002233 212 rs1812582 48 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 9 00002237 134 rs7967892 58 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 12 00002237 137 rs7838420 79 3 logistic albuminuria vs no albuminuria (follow-up) 8 00002238 145 rs2348914 141 1 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00002238 149 rs4976983 164 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00002239 074 rs259997 95 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 20 00002241 160 rs2169170 114 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00002242 069 rs619037 83 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00002243 140 rs1239771 125 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002243 070 rs41391845 71 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 9 00002243 174 rs871419 158 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00002244 130 rs41388648 202 7 logistic microalbuminuria vs no albuminuria (at entry) 2 00002244 073 rs6851194 68 4 logistic low creatinine clearance vs normal creatinine clearance 4 00002246 072 rs1929751 59 2 logistic albuminuria vs no albuminuria (at entry) 13 00002249 064 rs12713469 81 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 2 00002249 126 rs1035704 44 9 logistic albuminuria vs no albuminuria (follow-up) 15 00002249 131 rs10967436 48 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 9 0000225 134 rs12956604 109 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 0000225 141 rs470455 52 5 logistic macroalbuminuria vs no albuminuria (at entry) 18 0000225 062 rs2858638 61 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 22 00002251 069 rs6081676 43 0 logistic microalbuminuria vs no albuminuria (at entry) 20 00002251 271 rs7229063 109 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00002252 140 rs6547953 42 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00002252 065 rs2127547 78 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00002252 075 rs12485415 42 4 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00002253 246 rs7611991 112 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00002254 072 rs6007450 52 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 22 00002255 065 rs1932604 74 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 10 00002256 070 rs10774823 125 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00002256 127 rs731729 134 2 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00002257 151 rs2003013 110 8 logistic low creatinine clearance vs normal creatinine clearance 11 00002261 031 rs12489725 170 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 3 00002265 074 rs10743140 15 8 logistic albuminuria vs no albuminuria (at entry) 11 00002266 056 rs4456715 131 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00002267 069 rs6052724 12 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 20 00002267 137 rs10490803 180 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 3 00002267 064 rs6505710 41 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002267 144 rs10259377 66 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00002268 138 rs2838964 55 6 logistic microalbuminuria vs no albuminuria (at entry) 21 00002269 181

rs986866 434 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 0000227 069 rs11712727 904 logistic low glomerular fitration rate vs control (at entry) 3 00002271 178 rs7765427 91 2 logistic low glomerular fitration rate vs control (at entry) 6 00002273 159 rs2937813 12 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00002274 149 rs1258246 69 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 10 00002275 066 rs4905630 120 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 14 00002275 073 rs10495598 29 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00002278 139 rs10248305 66 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00002278 138 rs2740485 110 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 9 0000228 147 rs2960744 151 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 7 0000228 072 rs2587163 199 0 logistic albuminuria vs no albuminuria (follow-up) 4 00002281 078 rs6032948 28 3 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 00002283 071 rs562966 116 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 11 00002283 145 rs4258086 49 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 9 00002284 069 rs2736172 44 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00002285 129 rs11024875 22 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 11 00002285 062 rs10248305 664 logistic microalbuminuria vs no albuminuria (at entry) 7 00002289 138 rs11752805 166 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 0000229 135 rs595255 79 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 00002291 130 rs1466122 48 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00002291 078 rs6508259 50 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 18 00002291 137 rs16863926 188 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00002291 071 rs9886596 22 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 8 00002293 172 rs10234057 66 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00002293 140 rs17022224 59 2 logistic microalbuminuria vs no albuminuria (at entry) 2 00002293 203 rs9502593 11 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 00002295 129 rs17076524 145 7 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 6 00002297 193 rs13174713 12 9 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00002298 149 rs7493192 114 7 logistic low glomerular fitration rate vs control (follow-up) 14 00002298 064 rs9317560 50 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 13 000023 072 rs6427833 214 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00002303 144 rs17258731 146 1 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00002303 157 rs4664865 161 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 00002303 053 rs1459375 151 4 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 10 00002304 133 rs6925350 164 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 00002304 137 rs3846116 34 1 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00002305 137 rs6960667 134 6 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 7 00002305 171 rs558930 58 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 13 00002305 062 rs1812582 48 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 9 00002305 134 rs7660053 175 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00002307 130

rs16960516 45 0 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 15 00002308 057 rs11193235 103 9 logistic albuminuria vs no albuminuria (at entry) 10 00002309 077 rs1430382 87 2 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 0000231 074 rs4663113 1334 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 2 0000231 140 rs344708 28 4 logistic low glomerular fitration rate vs control (at entry) 5 00002311 067 rs10259377 66 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00002311 138 rs6715897 232 3 logistic low glomerular titration rate vs control (at entry) 2 00002312 057 rs17479 12 9 logistic low glomerular fitration rate vs control (at entry) 00002312 170 rs222931 22 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 21 00002312 082 rs2203661 79 6 logistic macroalbummuπa vs no albuminuria (at entry) 8 00002313 160 rs16889748 124 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 8 00002313 162 rs16994846 53 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 22 00002313 029 rs6595512 131 3 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00002314 133 rs922554 131 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 00002314 133 rs922553 131 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00002314 133 rs7705236 131 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00002314 133 rs922552 131 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00002314 133 rs2419533 131 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00002314 141 rs682970 29 6 logistic albuminuria vs no albuminuria (at entry) 10 00002315 228 rs6518240 55 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 21 00002315 144 rs7557611 164 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00002315 134 rs10998910 89 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 10 00002315 140 rs12161700 89 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 10 00002315 140 rs10823420 89 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 10 00002315 140 rs6711891 90 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00002315 139 rs7705409 131 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00002316 133 rs16917529 56 0 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00002316 135 rs1114418 137 3 logistic albuminuria vs no albuminuria (at entry) 11 00002317 076 rs3852539 49 1 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00002317 136 rs2075383 114 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 12 00002319 053 rs9686988 136 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 0000232 059 rs6996243 109 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 0000232 139 rs10193182 80 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 00002321 075 rs11951243 130 1 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00002322 148 rs8073228 48 6 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 17 00002322 136 rs3112857 198 8 logistic low glomerular fitration rate vs control (at entry) 4 00002322 149 rs7123164 7 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00002322 070 rs11701920 28 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 21 00002322 142 rs2839580 49 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 21 00002322 077 rs7723199 7 5 logistic low glomerular fitration rate vs control (follow-up) 00002323 153

rs2962615 5 9 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00002326 130 rs16939132 94 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00002326 138 rs3846820 80 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 6 00002326 072 rs6693866 288 4 logistic low glomerular fitration rate vs control (follow-up) 1 00002327 174 rs 13006847 133 5 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00002329 136 rs592228 243 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00002329 067 rs1929751 59 2 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 13 0000233 064 rs4235846 98 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 6 00002331 173 rs1459375 151 4 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 10 00002332 133 rs1396512 63 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 14 00002334 161 rs17479 12 9 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00002336 149 rs3852539 49 1 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00002336 136 rs2789417 166 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00002336 058 rs6518240 55 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 21 00002337 144 rs1491757 96 8 logistic low glomerular fitration rate vs control (follow-up) 3 00002338 062 rs2013004 48 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 9 00002338 137 rs6081676 43 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 20 00002338 271 rs7191770 11 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 16 0000234 196 rs 1254947 149 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 10 00002341 132 rs11720582 90 4 logistic low glomerular fitration rate vs control (at entry) 3 00002343 181 rs2193374 102 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00002343 050 rs6761875 45 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 2 00002343 146 rs7111704 140 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00002345 054 rs3852539 49 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00002345 134 rs34170515 147 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002346 131 rs2395672 50 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00002347 134 rs7203172 48 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 16 00002347 062 rs10514925 63 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 17 00002347 205 rs949229 41 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002347 144 rs11223077 141 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 11 00002349 047 rs6476126 7 0 logistic low glomerular fitration rate vs control (at entry) 9 0000235 147 rs6778834 73 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 3 0000235 066 rs17025554 113 2 logistic microalbuminuria vs no albuminuria (at entry) 2 00002352 068 rs4940275 68 2 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00002352 068 rs11848645 37 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 14 00002353 126 rs9325744 30 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 8 00002353 151 rs1965193 52 7 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 12 00002354 139 rs10166160 170 2 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 00002355 144 rs17587689 105 6 logistic low creatinine clearance vs normal creatinine clearance 4 00002355 064 rs17801910 78 0 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00002355 197

rs448666 60 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00002356 066 rs9325744 30 8 logistic albuminuria vs no albuminuria (at entry) 8 00002357 142 rs2683690 85 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 2 00002357 139 rs7236575 69 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00002357 160 rs7188142 80 2 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 16 00002358 153 rs11104736 94 4 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 12 00002359 137 rs10751020 84 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 0000236 077 rs11735854 43 3 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 4 00002362 064 rs7663340 146 8 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 4 00002364 080 rs1477437 28 5 logistic low glomerular titration rate vs control (follow-up) 15 00002366 189 rs4440442 82 3 logistic microalbuminuria vs no albuminuria (at entry) 6 00002366 075 rs4367362 82 3 logistic microalbuminuria vs no albuminuria (at entry) 6 00002366 075 rs9287229 262 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 1 00002367 139 rs748165 90 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 10 00002369 132 rs10111251 106 2 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 8 00002369 052 rs6503352 23 1 logistic albuminuria vs no albuminuria (at entry) 17 0000237 200 rs12125493 177 4 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 1 00002372 129 rs2937813 12 8 logistic low creatinine clearance vs normal creatinine clearance 5 00002372 153 rs7750426 166 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00002373 074 rs9317560 50 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry)

-J 13 00002373 072 -J rs3852539 49 1 logistic albuminuria vs no albuminuria (at entry) 12 00002374 134 rs8004558 86 8 logistic microalbuminuria vs no albuminuria (at entry) 14 00002374 160 rs16919323 105 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 00002374 239 rs6773962 173 6 logistic low glomerular titration rate vs control (at entry) 3 00002376 148 rs2741311 238 1 logistic low glomerular titration rate vs control (follow-up) 2 00002376 045 rs17101839 76 3 logistic AGE, SEX low glomerular titration rate vs control (at entry) 12 00002378 204 rs6595512 131 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 5 00002378 145 rs922554 131 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 5 00002378 145 rs7705236 131 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 5 00002378 145 rs922555 131 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 5 00002378 145 rs922553 131 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 5 00002378 145 rs922552 131 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 5 00002378 145 rs259991 95 3 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 20 0000238 237 rs6671391 214 8 logistic low glomerular titration rate vs control (follow-up) 1 0000238 177 rs10495444 262 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 1 00002383 139 rs11082650 68 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00002385 067 rs10898015 72 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00002389 066 rs1392695 113 9 logistic low glomerular titration rate vs control (follow-up) 3 0000239 154 rs11647317 67 3 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 00002393 129 rs1493902 71 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00002393 148

rs11688740 80 0 logistic GE, AGE, SEX macroalbummuπa vs no albuminuria (at entry) 2 00002394 164 rs12983573 33 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 19 00002394 073 rs2041908 31 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00002395 070 rs4810575 659 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 20 00002395 078 rs1361196 113 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00002397 158 rs4971264 235 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00002398 132 rs246277 130 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 00002399 157 rs629222 239 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 1 000024 143 rs4712300 33 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00002401 068 rs17818395 74 9 logistic albuminuria vs no albuminuria (at entry) 17 00002403 070 rs765 45 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 15 00002403 077 rs2396319 226 9 logistic microalbuminuria vs no albuminuria (at entry) 2 00002405 074 rs6975798 129 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 7 00002405 141 rs4141410 129 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 7 00002405 141 rs10471462 68 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002406 066 rs17186040 27 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00002406 062 rs221035 354 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 1 00002407 070 rs7299538 59 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00002408 072 rs1960847 37 7 logistic low creatinine clearance vs normal creatinine clearance 19 0000241 072 rs10963480 32 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 0000241 072

OO rs1378500 117 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00002411 181 rs1380316 151 4 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 10 00002412 135 rs17696165 151 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 00002412 184 rs12895324 55 4 logistic low glomerular fitration rate vs control (follow-up) 14 00002413 066 rs17233934 69 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 7 00002413 246 rs1647786 56 7 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00002413 066 rs11010400 464 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 10 00002414 233 rs1239771 125 1 logistic albuminuria vs no albuminuria (follow-up) 18 00002415 075 rs2396319 226 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00002416 074 rs9364250 185 8 logistic albuminuria vs no albuminuria (at entry) 6 00002419 076 rs1356952 134 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 00002419 144 rs10179954 69 8 logistic albuminuria vs no albuminuria (follow-up) 2 0000242 130 rs4132236 82 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 0000242 076 rs2960744 151 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 0000242 072 rs10058955 52 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00002423 077 rs716553 63 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00002423 130 rs629875 29 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00002425 070 rs12965571 41 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002426 141 rs1114418 137 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00002427 076 rs16931308 81 2 logistic macroalbuminuria vs no albuminuria (at entry) 8 00002427 205

rs7638955 95 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00002427 158 rs10467913 44 9 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 15 0000243 068 rs17479 12 9 logistic low creatinine clearance vs normal creatinine clearance 5 0000243 153 rs829584 48 7 logistic low glomerular fitration rate vs control (follow-up) 2 00002431 065 rs4659819 258 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00002432 078 rs6730550 131 6 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00002433 075 rs2401841 100 0 logistic albuminuria vs no albuminuria (at entry) 14 00002433 132 rs11701920 28 7 logistic microalbuminuria vs no albuminuria (at entry) 21 00002433 142 rs4796354 13 7 logistic microalbuminuria vs no albuminuria (at entry) 17 00002434 132 rs10817737 103 6 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00002435 074 rs733299 38 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 15 00002435 155 rs17753899 142 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00002435 061 rs8083437 87 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00002436 073 rs11609178 94 1 logistic macroalbuminuria vs no albuminuria (at entry) 12 00002436 196 rs4940275 68 2 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00002436 068 rs7308867 84 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 00002437 071 rs7592852 202 7 logistic microalbuminuria vs no albuminuria (at entry) 2 00002437 076 rs17492893 147 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002439 131 rs7765427 91 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 00002441 152 rs32062 159 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00002443 128 rs3104704 17 6 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00002444 142 rs2740485 110 6 logistic albuminuria vs no albuminuria (at entry) 9 00002444 147 rs629875 29 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00002444 070 rs17025554 113 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 00002445 068 rs11610143 65 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 12 00002447 066 rs5752554 27 8 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 22 00002447 041 rs6883415 164 1 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00002449 182 rs10898015 72 9 logistic microalbuminuria vs no albuminuria (at entry) 11 00002449 066 rs10743138 15 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 0000245 056 rs4810575 65 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 20 00002451 078 rs1455593 101 1 logistic microalbuminuria vs no albuminuria (at entry) 11 00002451 056 rs8094588 72 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00002451 073 rs496584 40 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 15 00002452 148 rs6547953 42 6 logistic macroalbuminuria vs no albuminuria (at entry) 2 00002452 065 rs12418662 115 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 11 00002453 074 rs1161263 95 2 logistic low glomerular fitration rate vs control (follow-up) 4 00002454 216 rs12535840 94 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 00002454 152 rs3100734 72 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 4 00002455 149 rs10163742 116 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 18 00002457 071 rs4702266 12 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00002457 073

rs4947696 73 3 logistic low glomerular fitration rate vs control (at entry) 7 00002459 066 rs2508492 116 1 logistic GE, AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 11 00002459 337 rs4688828 144 2 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 3 0000246 060 rs6427833 214 2 logistic GE ₁ AGE ₁ SEX low creatinine clearance vs normal creatinine clearance 1 00002461 144 rs17242747 32 1 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (follow-up) 11 00002464 074 rs8083437 87 3 logistic low creatinine clearance vs normal creatinine clearance 18 00002464 073 rs1859875 66 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00002465 137 rs1514417 17 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 21 00002472 154 rs7972260 143 9 logistic low glomerular fitration rate vs control (follow-up) 12 00002473 155 rs4118375 210 1 logistic albuminuria vs no albuminuria (follow-up) 3 00002473 071 rs354391 81 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00002473 075 rs1361196 113 1 logistic macroalbuminuria vs no albuminuria (at entry) 1 00002474 202 rs1416078 113 1 logistic macroalbuminuria vs no albuminuria (at entry) 1 00002474 202 rs12702054 66 3 logistic microalbuminuria vs no albuminuria (at entry) 7 00002474 137 rs7194394 107 5 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 16 00002475 168 rs2401841 100 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 00002476 134 rs4631962 9 2 logistic macroalbuminuria vs no albuminuria (at entry) 12 00002477 062 rs10058955 52 0 logistic albuminuria vs no albuminuria (follow-up) 5 00002479 077 rs8073228 48 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 17 0000248 136 rs7549770 151 1 logistic low glomerular fitration rate vs control (follow-up) 1 00002481 151

O rs11193235 103 9 logistic AGE ₁ SEX albuminuria vs no albuminuria (at entry) 10 00002481 077 rs1912108 95 7 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00002482 074 rs12590361 132 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 14 00002482 165 rs5752554 27 8 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 22 00002484 041 rs7841489 125 5 logistic low glomerular fitration rate vs control (follow-up) 8 00002484 047 rs1161262 95 2 logistic AGE ₁ SEX low glomerular fitration rate vs control (follow-up) 4 00002484 211 rs7988514 6 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00002484 076 rs1930994 130 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 00002485 075 rs7119426 66 7 logistic low glomerular fitration rate vs control (follow-up) 11 00002486 155 rs6065466 57 8 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 00002487 136 rs2190963 23 2 logistic microalbuminuria vs no albuminuria (at entry) 17 00002489 213 rs10179954 69 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00002491 130 rs1464611 128 6 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (at entry) 8 00002492 127 rs221035 35 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00002492 076 rs7672528 92 2 logistic low glomerular fitration rate vs control (at entry) 4 00002493 231 rs16880395 43 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00002493 061 rs615847 83 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00002493 140 rs6114956 48 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 20 00002494 057 rs10043682 130 0 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00002495 135 rs353972 82 3 logistic low glomerular fitration rate vs control (follow-up) 5 00002496 022

rs11886084 383 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 2 00002496 157 rs10970744 561 logistic AGE, SEX low glomerular titration rate vs control (at entry) 9 00002498 149 rs2587163 1990 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00002498 078 rs7742617 302 logistic low glomerular fitration rate vs control (at entry) 6 000025 157 rs10736593 137 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 000025 076 rs9812338 90 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 000025 068 rs2851912 41 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00002502 074 rs2851911 41 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00002502 074 rs2849395 41 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00002502 074 rs2401841 100 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 14 00002503 132 rs6861743 108 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00002505 212 rs257654 103 2 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 19 00002505 152 rs1975980 48 8 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 17 00002506 138 rs17021710 146 6 logistic albuminuria vs no albuminuria (follow-up) 4 00002507 032 rs268485 19 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00002508 053 rs16854563 212 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 2 00002508 170 rs7047148 78 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 00002509 201 rs4895849 123 5 logistic GE ₁ AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 00002509 069 rs11216633 112 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 11 0000251 155 rs926082 43 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 21 00002511 149 rs1545653 88 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 00002511 044 rs17095305 98 2 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 00002512 395 rs4741793 7 0 logistic low glomerular fitration rate vs control (follow-up) 9 00002513 150 rs34170515 147 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002513 131 rs11724319 146 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 4 00002513 072 rs2014525 120 1 logistic GE ₁ AGE, SEX low creatinine clearance vs normal creatinine clearance 14 00002514 070 rs17818395 74 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 17 00002516 070 rs12211633 46 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 6 00002518 074 rs617595 59 8 logistic microalbuminuria vs no albuminuria (at entry) 13 00002519 137 rs17492893 147 8 logistic albuminuria vs no albuminuria (at entry) 5 0000252 131 rs2921571 12 8 logistic low creatinine clearance vs normal creatinine clearance 5 0000252 153 rs2031654 51 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 00002524 067 rs2093852 207 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00002525 066 rs6478519 131 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 9 00002526 229 rs12474326 9 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00002526 128 rs2278860 40 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 15 00002527 145 rs4664865 161 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 2 0000253 053 rs2930629 6 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 15 0000253 073 rs2412531 38 4 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 15 00002533 132 rs10489525 148 1 logistic albuminuria vs no albuminuria (follow-up) 1 00002535 076

rs17021632 146 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00002535 C)34 rs2401841 100 0 logistic microalbuminuria vs no albuminuria (at entry) 14 00002535 34 rs7678921 77 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00002536 44 rs168218 70 7 logistic microalbuminuria vs no albuminuria (at entry) 13 00002536 33 rs17078168 8 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 8 00002537 ( 557 rs9487891 118 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 0000254 ( D 54 rs470455 52 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 18 00002541 ( D 62 rs10248305 66 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00002541 38 rs17492893 147 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002542 31 rs7696553 77 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00002543 45 rs7672620 77 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00002543 45 rs17654227 66 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00002543 40 rs4387746 170 2 logistic albuminuria vs no albuminuria (at entry) 2 00002544 43 rs781758 124 4 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 00002545 60 rs11132476 204 8 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 00002546 26 rs34170515 147 8 logistic albuminuria vs no albuminuria (at entry) 5 00002547 31 rs13008483 784 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00002547 69 rs4403634 222 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 00002548 40 rs575559 294 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00002548 ( 370 rs2026692 44 4 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00002548 57 rs11735854 43 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00002549 ( D 73 rs7926119 53 6 logistic macroalbuminuria vs no albuminuria (at entry) 11 0000255 54 rs10485358 81 0 logistic GE ₁ AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 0000255 I 27 rs7921561 116 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 10 0000255 139 rs1571567 103 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 9 00002551 ( 376 rs17204962 157 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00002551 ( D50 rs7119964 15 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00002553 ( D 55 rs11216633 112 8 logistic albuminuria vs no albuminuria (follow-up) 11 00002553 I 55 rs1864964 154 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 5 00002555 ( D 64 rs6925350 164 4 logistic albuminuria vs no albuminuria (at entry) 6 00002558 137 rs2404535 133 5 logistic low creatinine clearance vs normal creatinine clearance 2 00002558 138 rs12211633 46 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 6 0000256 374 rs41391845 71 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 00002561 174 rs619037 83 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00002562 140 rs11150225 104 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 00002562 163 rs6590788 148 7 logistic low creatinine clearance vs normal creatinine clearance 11 00002563 ( 347 rs2277924 151 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 00002563 133 rs1932604 74 5 logistic albuminuria vs no albuminuria (at entry) 10 00002564 ( 370 rs17427286 147 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002565 31 rs10197305 90 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00002565 39

rs 17272796 41 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 0 0002566 1 34 rs2104042 248 4 logistic macroalbuminuπa vs no albuminuria (at entry) 1 0 0002567 0 63 rs2104043 248 4 logistic macroalbuminuπa vs no albuminuria (at entry) 1 0 0002567 0 63 rs17099250 67 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 14 0 0002568 1 39 rs6127813 86 1 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 20 0 0002569 0 71 rs6537549 69 7 logistic low glomerular fitration rate vs control (at entry) 10 0 000257 1 44 rs575559 29 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 0 0002571 0 70 rs1331484 0 9 logistic microalbuminuria vs no albuminuria (at entry) 6 0 0002572 1 35 rs1678030 130 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 14 0 0002573 0 61 rs807525 41 8 logistic microalbuminuria or macrøalbuminuπa vs control (follow-up) 6 0 0002573 0 60 rs2699365 131 7 logistic low glomerular fitration rate vs control (follow-up) 2 0 0002575 0 68 rs9457730 164 6 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 6 0 0002577 1 44 rs9461799 45 7 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 6 0 0002579 1 34 rs1292081 56 4 logistic low glomerular fitration rate vs control (follow-up) 1 0 0002581 0 54 rs682970 29 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 10 0 0002581 2 28 rs2353545 222 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 0 0002583 1 56 rs3743033 38 7 logistic low creatinine clearance vs normal creatinine clearance 15 0 0002585 1 39 rs3108049 78 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 0 0002585 1 64 rs17559639 46 2 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 0 0002586 1 37 rs17021710 146 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 0 0002587 0 32 rs17078168 8 6 logistic microalbuminuria vs no albuminuria (at entry) 8 0 0002587 0 57 rs7645279 46 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 0 0002588 0 79 rs4323877 145 0 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 11 0 0002589 1 49 rs2413429 42 0 logistic low glomerular fitration rate vs control (follow-up) 22 0 000259 0 67 rs7047148 78 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 0 000259 2 01 rs7208976 18 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 17 0 000259 0 68 rs2465791 73 3 logistic low glomerular fitration rate vs control (at entry) 7 0 0002591 0 66 rs7947110 12 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 0 0002592 1 31 rs10742654 53 6 logistic macroalbuminuria vs no albuminuria (at entry) 11 0 0002594 1 55 rs10957769 94 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 0 0002599 1 38 rs7229063 109 3 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 0 00026 1 40 rs687188 129 8 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 0 00026 0 67 rs7136397 59 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 0 00026 1 38 rs2738078 9 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 0 00026 0 66 rs7197544 104 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 0 0002601 1 64 rs 16884604 123 8 logistic low glomerular fitration rate vs control (at entry) 8 0 0002602 0 63 rs17078168 8 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 8 0 0002602 0 57 rs2009333 77 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 0 0002603 1 44 rs2131887 239 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 1 0 0002604 0 74 rs1380316 151 4 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 10 0 0002606 1 35

rs10431158 72 8 logistic low glomerular titration rate vs control (follow-up) 11 00002607 156 rs16964862 88 2 logistic low creatinine clearance vs normal creatinine clearance 13 00002607 146 rs2090980 84 8 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00002607 145 rs7951266 53 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00002607 135 rs7705409 131 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 5 00002607 144 rs6862278 175 0 logistic low creatinine clearance vs normal creatinine clearance 5 00002608 240 rs6508259 50 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 18 0000261 135 rs10743138 15 8 logistic albuminuria vs no albuminuria (at entry) 11 00002611 056 rs2243614 31 1 logistic HBP microalbuminuria vs no albuminuria (at entry) 9 00002611 146 rs748165 90 9 logistic albuminuria vs no albuminuria (at entry) 10 00002612 132 rs2730306 20 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 3 00002612 192 rs922556 131 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 5 00002612 144 rs2344863 80 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 15 00002613 136 rs17446325 146 8 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 12 00002615 052 rs245820 145 8 logistic low glomerular titration rate vs control (follow-up) 5 00002617 063 rs9325744 30 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 8 00002618 142 rs9911421 23 2 logistic albuminuria vs no albuminuria (at entry) 17 0000262 202 rs922556 131 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 5 0000262 133 rs17670198 804 logistic albuminuria vs no albuminuria (follow-up) 3 00002621 130 rs7977693 96 0 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 00002621 141 rs 17767946 46 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00002622 137 rs2936535 8 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 00002622 068 rs538343 98 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00002622 067 rs 10875745 63 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00002624 132 rs284689 57 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 19 00002625 128 rs1529579 117 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00002625 069 rs215759 654 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 1 00002626 145 rs4728666 98 0 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00002626 128 rs16939145 94 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00002629 138 rs6589065 102 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00002629 239 rs17796589 63 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 00002629 156 rs 10790444 117 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00002631 070 rs6095325 71 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 20 00002631 073 rs41494550 191 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00002631 038 rs1361196 113 1 logistic albuminuria vs no albuminuria (at entry) 1 00002632 158 rs401859 71 0 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 5 00002633 134 rs11132476 204 8 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 4 00002634 126 rs11598494 16 7 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 10 00002634 132 rs17824261 20 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 3 00002634 028 rs1932604 74 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 10 00002635 070

rs1026847 56 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00002636 134 rs6564988 110 7 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 16 00002637 231 rs12423492 90 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00002637 060 rs10156011 33 4 logistic low glomerular titration rate vs control (follow-up) 7 00002638 067 rs763591 80 3 logistic low glomerular titration rate vs control (follow-up) 16 00002638 152 rs13276054 46 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00002638 070 rs1434764 84 0 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 8 00002639 076 rs2194325 80 2 logistic low glomerular titration rate vs control (follow-up) 16 00002639 152 rs4440442 82 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00002639 075 rs7136397 594 logistic microalbuminuria or macroalbuminuria vs control (at entry) 12 00002639 138 rs2359630 16 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 4 0000264 132 rs6975798 129 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 0000264 141 rs4141410 129 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 0000264 141 rs17025554 113 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00002641 068 rs6505710 41 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002641 144 rs7119964 15 8 logistic albuminuria vs no albuminuria (at entry) 11 00002642 055 rs17509991 76 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00002644 044 rs7765427 91 2 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 6 00002644 152 rs4677766 220 1 logistic macroalbuminuria vs no albuminuria (at entry) 3 00002645 057 rs7648466 69 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00002646 076 rs538343 984 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 11 00002646 067 rs1455593 101 1 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00002649 056 rs17330985 109 0 logistic AGE, SEX low glomerular titration rate vs control (at entry) 10 0000265 042 rs745165 107 0 logistic low creatinine clearance vs normal creatinine clearance 20 0000265 165 rs11027539 30 1 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 11 00002651 153 rs2412511 38 1 logistic AGE, SEX low glomerular titration rate vs control (at entry) 15 00002651 070 rs9523996 72 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00002651 158 rs7302315 93 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00002651 073 rs4775711 45 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 15 00002653 064 rs1430373 87 2 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 18 00002654 134 rs4658507 273 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 1 00002655 078 rs7646681 119 0 logistic macroalbuminuria vs no albuminuria (at entry) 3 00002655 172 rs6012271 68 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 20 00002655 138 rs2158951 664 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00002656 139 rs7067971 122 9 logistic low glomerular titration rate vs control (follow-up) 10 00002657 067 rs2736172 44 9 logistic albuminuria vs no albuminuria (follow-up) 6 00002658 129 rs4702266 12 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 00002658 073 rs2468255 94 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00002659 065 rs11595123 11 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00002659 073 rs17042290 84 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 00002659 072

rs8094588 72 8 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 18 00002659 073 rs7621243 42 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00002659 062 rs750576 206 5 logistic low glomerular titration rate vs control (at entry) 2 00002661 068 rs8056052 67 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 16 00002661 135 rs12796585 32 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 11 00002662 074 rs7185053 27 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 00002662 067 rs10790175 111 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 11 00002662 148 rs4775711 45 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 15 00002665 078 rs4657486 177 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 1 00002666 131 rs2088707 144 0 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 12 00002667 156 rs6694745 242 0 logistic low creatinine clearance vs normal creatinine clearance 1 00002669 178 rs10500411 78 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 16 0000267 170 rs6745998 31 6 logistic low glomerular fitration rate vs control (follow-up) 2 0000267 162 rs17770541 83 9 logistic low glomerular fitration rate vs control (at entry) 18 00002671 067 rs11243150 11 4 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00002671 130 rs10788562 102 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00002672 130 rs284689 57 3 logistic albuminuria vs no albuminuria (at entry) 19 00002676 128 rs716553 63 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00002676 129 rs17709552 62 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 11 00002677 053 rs1655131 167 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry)

OO 10 00002677 076 rs1011275 75 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 00002677 077 rs17678704 165 1 logistic low glomerular fitration rate vs control (at entry) 4 00002678 049 rs17680905 43 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00002678 075 rs453572 118 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00002678 074 rs7926119 53 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 0000268 154 rs17779263 95 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 17 00002681 178 rs16837766 261 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00002682 066 rs6427833 214 2 logistic low glomerular fitration rate vs control (follow-up) 1 00002684 163 rs4940957 87 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00002685 073 rs1885290 71 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 20 00002685 073 rs13316352 172 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00002685 146 rs17631610 165 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00002686 155 rs17782173 43 3 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00002688 151 rs17824255 20 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 00002688 030 rs3950018 92 6 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 0000269 053 rs4367362 82 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 0000269 075 rs9325744 30 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 8 00002691 142 rs10786968 126 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00002691 142 rs11696281 48 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 20 00002692 057 rs11701920 28 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 21 00002692 142

rs6081676 43 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 20 00002693 256 rs10504846 102 0 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 8 00002693 151 rs16893391 90 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 6 00002695 043 rs17680905 43 3 logistic albuminuria vs no albuminuria (at entry) 4 00002695 074 rs7638955 95 3 logistic microalbuminuria vs no albuminuria (at entry) 3 00002696 158 rs6715897 232 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 00002698 057 rs9317562 50 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 13 000027 072 rs6541155 239 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 000027 075 rs4580841 82 3 logistic microalbuminuria vs no albuminuria (at entry) 6 00002701 076 rs7300192 65 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 12 00002702 076 rs17779263 95 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 17 00002702 178 rs10275303 138 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 7 00002702 153 rs6737578 5 7 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00002704 218 rs8099832 87 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00002704 074 rs10743138 15 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00002706 056 rs4403634 222 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00002708 156 rs10502074 101 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 11 00002709 070 rs17156226 110 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00002709 161 rs4688828 144 2 logistic albuminuria vs no albuminuria (follow-up) 3 0000271 060 rs11707973 152 6 logistic low glomerular fitration rate vs control (follow-up) 3 00002711 066 rs17725296 42 6 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00002711 062 rs2343508 174 8 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00002712 081 rs11197169 134 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 10 00002717 188 rs1861619 202 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 00002718 076 rs1553953 49 7 logistic albuminuria vs no albuminuria (follow-up) 12 00002718 067 rs6825958 66 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00002719 070 rs922555 131 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00002721 132 rs1389798 93 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00002721 073 rs12301748 17 2 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 00002721 058 rs6778834 73 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00002721 066 rs1241940 91 6 logistic albuminuria vs no albuminuria (at entry) 14 00002726 150 rs7119964 15 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00002727 055 rs7228353 106 7 logistic albuminuria vs no albuminuria (follow-up) 18 00002727 077 rs1548447 37 1 logistic low creatinine clearance vs normal creatinine clearance 16 00002727 187 rs574776 29 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00002727 070 rs17696165 151 7 logistic macroalbuminuria vs no albuminuria (at entry) 7 00002727 184 rs12120173 243 1 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00002728 139 rs168218 70 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 13 00002729 133 rs4894760 181 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 00002729 081 rs17080277 66 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 13 00002732 067

rs9317562 504 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00002732 072 rs41521644 191 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00002732 050 rs7082705 102 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00002733 131 rs9354486 82 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 00002736 077 rs11101370 69 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 10 00002736 079 rs558930 58 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00002738 059 rs3852539 49 1 logistic microalbuminuria vs no albuminuria (at entry) 12 00002738 136 rs7299538 59 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00002738 072 rs4940957 87 3 logistic low creatinine clearance vs normal creatinine clearance 18 00002739 073 rs7042894 56 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00002741 135 rs4643103 84 9 logistic low glomerular Titration rate vs control (at entry) 11 00002742 155 rs268599 88 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 8 00002742 144 rs6472931 94 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00002742 138 rs6472930 94 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00002742 138 rs3922038 94 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00002742 138 rs791743 191 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00002742 138 rs6065466 57 8 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 00002745 136 rs2169170 114 5 logistic albuminuria vs no albuminuria (follow-up) 18 00002745 069 rs4385034 175 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00002745 129 rs1430377 87 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00002747 071

00 rs1806753 174 8 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00002748 078 rs725961 78 8 logistic low glomerular fitration rate vs control (follow-up) 9 0000275 066 rs12702054 66 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 0000275 137 rs1028767 13 0 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 13 0000275 082 rs1493902 71 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 0000275 148 rs4412753 27 5 logistic low creatinine clearance vs normal creatinine clearance 11 00002751 069 rs7335946 6 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00002751 141 rs11857247 384 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 15 00002753 136 rs7194394 107 5 logistic low glomerular fitration rate vs control (follow-up) 16 00002754 166 rs2292927 159 2 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 00002756 141 rs2090018 44 2 logistic albuminuria vs no albuminuria (follow-up) 17 00002757 074 rs10742654 53 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 00002757 155 rs8101149 71 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 19 00002758 071 rs10978601 112 5 logistic low creatinine clearance vs normal creatinine clearance 9 00002758 157 rs4981158 6 5 logistic low glomerular fitration rate vs control (follow-up) 14 00002759 064 rs151052 69 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 20 00002759 135 rs6894886 40 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00002759 067 rs3111694 81 4 logistic microalbuminuria vs no albuminuria (at entry) 4 00002759 133 rs13282254 135 9 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 0000276 195 rs2730306 20 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 3 0000276 220

rs3919653 5 1 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 7 00002761 136 rs17670198 80 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00002761 130 rs6479616 96 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 00002761 039 rs3846820 80 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 00002762 072 rs704829 191 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00002763 138 rs6673397 204 5 logistic low glomerular titration rate vs control (at entry) 1 00002764 297 rs9646596 76 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00002764 044 rs11027538 30 1 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 11 00002765 150 rs4663113 133 4 logistic AGE, SEX low glomerular titration rate vs control (at entry) 2 00002765 154 rs10076 45 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00002765 234 rs4367362 82 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 00002765 075 rs748165 90 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00002766 132 rs6737578 5 7 logistic low glomerular titration rate vs control (at entry) 2 00002767 289 rs879574 4 0 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 22 00002767 171 rs4629927 15 0 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00002768 127 rs1382394 87 3 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 18 00002769 074 rs11243149 11 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00002769 130 rs17427286 147 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002771 131 rs11848645 37 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 00002772 136 rs6050170 48 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 20 00002774 057

OO

VO rs6050164 48 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 20 00002774 057 rs6050183 48 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 20 00002774 057 rs7264679 48 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 20 00002774 057 rs6106974 48 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 20 00002774 057 rs10124870 112 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00002774 161 rs10790175 111 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00002774 148 rs17157227 62 3 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 11 00002776 056 rs10495598 29 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00002776 155 rs11815121 142 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00002777 061 rs 10875745 63 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00002777 129 rs1161262 95 2 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 4 00002782 165 rs17076531 145 7 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 6 00002782 191 rs10736593 137 3 logistic albuminuria vs no albuminuria (at entry) 11 00002782 076 rs7653303 130 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 3 00002782 136 rs11023705 21 1 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00002782 076 rs13174713 12 9 logistic low creatinine clearance vs normal creatinine clearance 5 00002784 152 rs574776 29 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00002784 070 rs3790659 177 5 logistic GE ₁ AGE ₁ SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 1 00002788 130 rs10489525 148 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00002788 076 rs2013112 79 0 logistic AGE, SEX low glomerular titration rate vs control (at entry) 8 00002789 130

rs4905630 120 1 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 14 0000279 070 rs7236339 125 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 18 0000279 134 rs6582 384 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 15 00002791 134 rs9519630 89 7 logistic macroalbuminuria vs no albuminuria (at entry) 13 00002791 061 rs4290350 89 7 logistic macroalbuminuria vs no albuminuria (at entry) 13 00002791 061 rs41388648 202 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00002792 073 rs9819830 112 0 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 3 00002793 072 rs4873692 67 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 8 00002794 081 rs12446492 39 0 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 16 00002796 063 rs1061860 215 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00002799 132 rs11023705 21 1 logistic microalbuminuria vs no albuminuria (at entry) 11 000028 076 rs7638955 95 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00002801 158 rs7213631 48 7 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 17 00002802 138 rs603397 75 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 00002802 081 rs10223785 2 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 00002802 050 rs2953310 49 6 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 00002804 150 rs2186975 14 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 21 00002805 138 rs1472610 32 5 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 5 00002806 059 rs10736593 137 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00002806 076 rs10122952 112 5 logistic low creatinine clearance vs normal creatinine clearance 00002807 157

VO O rs11169761 65 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 00002807 122 rs7493192 114 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 14 00002809 070 rs17427286 147 8 logistic albuminuria vs no albuminuria (at entry) 5 0000281 131 rs7243021 68 2 logistic albuminuria vs no albuminuria (at entry) 18 00002811 078 rs7988254 73 8 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 13 00002812 138 rs7559074 90 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00002812 133 rs2250259 43 4 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 4 00002814 068 rs151052 69 6 logistic albuminuria vs no albuminuria (follow-up) 20 00002814 135 rs2053158 101 5 logistic low glomerular titration rate vs control (at entry) 17 00002816 158 rs937525 134 6 logistic microalbuminuria vs no albuminuria (at entry) 12 00002816 138 rs1239771 125 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002816 070 rs8092690 117 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 00002817 042 rs9584245 73 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 13 00002818 142 rs2838964 55 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 21 00002818 181 rs41391845 71 9 logistic low glomerular titration rate vs control (follow-up) 9 00002819 187 rs6814897 95 2 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 4 0000282 158 rs1812582 48 0 logistic albuminuria vs no albuminuria (at entry) 9 0000282 134 rs12423492 90 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00002821 066 rs4243177 104 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 00002821 137 rs3847233 7 0 logistic low glomerular titration rate vs control (follow-up) 9 00002822 150

^CJ)

rs3762503 155 5 logistic low glomerular fitration rate vs control (follow-up) 2 00002822 068 rs550523 26 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00002822 144 rs7119426 66 7 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 11 00002823 139 rs1539542 27 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00002827 069 rs10499504 27 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 7 00002829 068 rs4573006 59 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00002829 073 rs4902490 72 6 logistic low glomerular titration rate vs control (follow-up) 14 0000283 147 rs4777205 70 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 15 0000283 071 rs6081676 43 0 logistic albuminuria vs no albuminuria (at entry) 20 00002831 256 rs1241940 91 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 14 00002831 150 rs1356704 42 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00002831 063 rs1529579 117 9 logistic low glomerular titration rate vs control (at entry) 11 00002833 061 rs10790444 117 9 logistic low glomerular titration rate vs control (at entry) 11 00002833 061 rs3768003 89 2 logistic low glomerular titration rate vs control (follow-up) 1 00002833 192 rs10500932 28 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00002833 152 rs226799 69 9 logistic AGE, SEX low glomerular titration rate vs control (at entry) 20 00002834 076 rs31899 22 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00002835 188 rs10904339 11 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 10 00002835 067 rs982295 92 8 logistic low creatinine clearance vs normal creatinine clearance 14 00002836 141 rs10150355 15 0 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 14 00002836 190 rs1258323 69 7 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 10 00002837 068 rs10733459 56 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00002839 134 rs11724319 146 0 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 4 00002839 072 rs7781264 75 5 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 7 0000284 072 rs10510816 77 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00002841 072 rs7690478 57 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 4 00002842 141 rs17568979 72 7 logistic low glomerular titration rate vs control (follow-up) 2 00002843 218 rs7746351 166 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00002843 134 rs16824208 130 6 logistic low creatinine clearance vs normal creatinine clearance 3 00002845 160 rs10967436 48 0 logistic albuminuria vs no albuminuria (follow-up) 9 00002846 134 rs41482845 186 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 3 00002846 054 rs1529289 131 7 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 2 00002847 067 rs6427833 214 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 00002848 167 rs6673013 208 7 logistic albuminuria vs no albuminuria (follow-up) 1 00002848 142 rs7745522 46 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 00002848 027 rs17801910 78 0 logistic albuminuria vs no albuminuria (at entry) 12 00002849 186 rs6445024 181 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 00002851 081 rs526061 47 3 logistic low creatinine clearance vs normal creatinine clearance 10 00002852 147 rs3753305 187 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00002852 075 rs10070326 8 0 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 5 00002855 408

rs13204439 170 3 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 6 00002855 070 rs8004558 86 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 00002856 160 rs10489628 99 4 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00002857 078 rs9457730 164 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 00002857 144 rs4971264 235 0 logistic microalbuminuria vs no albuminuria (at entry) 1 00002859 132 rs562966 116 2 logistic low glomerular fitration rate vs control (at entry) 11 0000286 171 rs1482047 102 3 logistic albuminuria vs no albuminuria (at entry) 11 0000286 161 rs2254221 38 3 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00002862 067 rs10177595 45 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00002862 155 rs11931592 55 8 logistic albuminuria vs no albuminuria (follow-up) 4 00002862 140 rs6503352 23 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 17 00002863 200 rs10851396 38 4 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 15 00002867 149 rs9926403 67 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 16 00002868 132 rs720727 71 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 20 0000287 073 rs6955265 151 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 7 0000287 074 rs4677766 220 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00002872 057 rs615847 83 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00002872 140 rs13300278 102 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 9 00002873 130 rs11259272 18 0 logistic AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 10 00002874 150 rs1351887 105 5 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (at entry) 18 00002875 053

K> rs9287229 262 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00002878 130 rs1655131 167 6 logistic microalbuminuria vs no albuminuria (at entry) 10 00002879 076 rs10124870 112 4 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00002881 159 rs4514740 44 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 17 00002882 070 rs2290482 143 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 00002883 191 rs17818395 74 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 17 00002884 074 rs6975798 129 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 00002884 141 rs4141410 129 8 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 00002884 141 rs6801579 99 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 3 00002885 128 rs2219547 1354 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00002886 176 rs17156226 110 6 logistic albuminuria vs no albuminuria (follow-up) 5 00002887 161 rs4936625 117 9 logistic low glomerular fitration rate vs control (at entry) 11 00002888 059 rs17692715 85 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 6 00002888 066 rs7559347 119 5 logistic low creatinine clearance vs normal creatinine clearance 2 00002888 137 rs7243021 68 2 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 18 00002891 078 rs16929523 47 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 00002891 191 rs17680905 43 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 4 00002892 074 rs7567280 186 0 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 2 00002892 079 rs2592115 239 7 logistic macroalbuminuria vs no albuminuria (at entry) 2 00002892 153 rs1378500 117 1 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 5 00002892 181

rs7516762 215 4 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 1 00002892 062 rs17190154 76 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 13 00002893 070 rs6960667 134 6 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 7 00002894 171 rs10934312 130 6 logistic low creatinine clearance vs normal creatinine clearance 3 00002895 160 rs1980892 209 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 00002896 128 rs1000927 28 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 21 00002897 149 rs7970563 80 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 00002899 073 rs934609 45 1 logistic low glomerular fitration rate vs control (at entry) 2 000029 146 rs4456715 131 7 logistic low creatinine clearance vs normal creatinine clearance 2 000029 071 rs6955265 151 1 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00002903 074 rs4796354 13 7 logistic AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 17 00002905 132 rs11724319 146 0 logistic microalbuminuria vs no albuminuria (at entry) 4 00002905 072 rs1334811 49 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 9 00002907 049 rs748165 90 9 logistic albuminuria vs no albuminuria (follow-up) 10 00002908 132 rs1489922 172 8 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 0000291 060 rs2024476 66 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00002911 073 rs1514417 17 9 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs control (at entry) 21 00002912 164 rs4132236 82 3 logistic microalbuminuria vs no albuminuria (at entry) 6 00002913 076 rs2623770 95 2 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 00002914 159 rs10177595 45 0 logistic low glomerular fitration rate vs control (at entry) 2 00002914 147 rs12657171 68 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 00002914 056 rs10817737 103 6 logistic GE ₁ AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00002915 074 rs2090980 84 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 11 00002915 154 rs7947110 12 7 logistic albuminuria vs no albuminuria (at entry) 11 00002916 131 rs719213 123 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 8 00002916 069 rs3956319 116 9 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 00002919 144 rs2885865 804 logistic GE ₁ AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00002919 077 rs11104736 94 4 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 12 00002922 137 rs17428570 147 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002924 131 rs166412 119 0 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00002924 064 rs2842754 222 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 00002925 165 rs617595 59 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 13 00002925 137 rs12120173 243 1 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00002927 139 rs16837766 261 3 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00002929 069 rs907290 94 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 8 00002931 115 rs16842040 241 9 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs control (at entry) 1 00002931 141 rs7590007 29 4 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 2 00002932 151 rs1430373 87 2 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00002933 134 rs1865977 84 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 16 00002933 080 rs1054496 174 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00002934 124

rs1002169 3 0 logistic GE, AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 7 00002934 053 rs7492012 27 7 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 13 00002937 137 rs4586627 226 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00002937 070 rs4775711 45 0 logistic albuminuria vs no albuminuria (at entry) 15 00002939 078 rs6589065 102 3 logistic albuminuria vs no albuminuria (at entry) 11 00002939 186 rs4685409 41 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 3 00002941 151 rs401859 71 0 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00002942 134 rs4387746 170 2 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 00002942 143 rs2445859 104 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 19 00002942 152 rs2243614 31 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 9 00002942 146 rs221035 35 4 logistic albuminuria vs no albuminuria (follow-up) 1 00002944 076 rs2981277 79 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 00002947 129 rs2833998 30 2 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 21 00002947 134 rs6095325 71 6 logistic AGE, SEX microalbuminuria or microalbuminuria vs control (at entry) 20 00002947 073 rs11931592 55 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00002947 140 rs 1678030 130 9 logistic albuminuria vs no albuminuria (follow-up) 14 00002948 061 rs 10430114 79 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00002948 073 rs7651436 68 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 3 0000295 276 rs10851198 95 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 13 0000295 077 rs 10963480 32 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 9 00002951 072

VO rs6589065 102 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 11 00002951 239 rs12030639 218 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00002951 075 rs7745522 46 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 6 00002951 027 rs17121123 92 8 logistic low creatinine clearance vs normal creatinine clearance 14 00002952 141 rs10193792 157 8 logistic low glomerular fitration rate vs control (at entry) 2 00002953 064 rs2825233 10 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 21 00002954 062 rs10499504 27 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00002954 068 rs7653303 130 0 logistic albuminuria vs no albuminuria (at entry) 3 00002955 136 rs10124870 112 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00002955 161 rs7248526 35 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 19 00002955 316 rs10857590 69 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 10 00002955 078 rs11752805 166 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00002955 134 rs7647840 181 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 00002958 081 rs268485 19 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00002959 053 rs4580841 82 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00002959 076 rs4321205 38 9 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 16 00002962 066 rs4280249 38 9 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 00002962 066 rs4369676 38 9 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 00002962 066 rs1218661 262 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 1 00002962 138 rs13300278 102 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 9 00002966 128

rs17025554 113 2 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 2 00002967 066 rs10500932 28 8 logistic albuminuria vs no albuminuria (at entry) 11 00002968 152 rs4535211 41 8 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00002969 135 rs753359 199 0 logistic albuminuria vs no albuminuria (follow-up) 4 00002969 078 rs1322051 49 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 00002969 047 rs3112857 198 8 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00002973 141 rs10485282 89 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 6 00002975 053 rs7233192 87 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00002975 071 rs11125629 44 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00002976 157 rs6751830 202 7 logistic microalbuminuria vs no albuminuria (at entry) 2 00002976 074 rs6926642 166 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00002976 073 rs34273034 112 9 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 8 00002977 065 rs1673887 118 6 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00002977 061 rs2248225 19 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 21 00002977 135 rs9592445 50 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 13 00002978 069 rs17655355 88 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 0000298 076 rs1202201 34 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 6 00002981 142 rs17345786 117 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 00002982 130 rs12953319 87 3 logistic low creatinine clearance vs normal creatinine clearance 18 00002984 073 rs1169752 52 7 logistic low creatinine clearance vs normal creatinine clearance 9 00002984 143 rs1371225 72 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 4 00002985 264 rs603151 26 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00002985 143 rs7685386 135 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 4 00002987 081 rs11702528 7 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 21 00002988 069 rs7238248 94 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 18 00002989 049 rs10894319 137 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 11 00002989 073 rs10758202 57 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 9 0000299 068 rs4372536 62 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 12 00002991 138 rs1112094 92 8 logistic low glomerular fitration rate vs control (at entry) 14 00002992 068 rs3743033 38 7 logistic low glomerular fitration rate vs control (at entry) 15 00002992 148 rs631408 79 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 00002992 128 rs10124870 112 4 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00002993 159 rs7592852 202 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00002993 076 rs7111704 140 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00002994 054 rs10399860 262 8 logistic low glomerular fitration rate vs control (follow-up) , 1 00002995 066 rs10070447 156 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00002995 077 rs6825958 66 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 4 00002995 070 rs12446492 39 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00002995 073 rs7992054 89 7 logistic macroalbuminuria vs no albuminuria (at entry) 13 00002997 061 rs3909441 89 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 1 00002997 188

rs11027540 30 1 logistic GE ₁ AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 11 00002998 151 rs344701 28 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 5 00002998 072 rs2732234 114 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00002998 072 rs6052724 12 4 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 20 00002999 155 rs2896769 112 0 logistic albuminuria vs no albuminuria (follow-up) 18 00003 076 rs1986877 55 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 7 00003001 065 rs2896769 112 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00003001 076 rs562966 116 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 11 00003003 171 rs9815517 24 7 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 3 00003004 074 rs10970744 56 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 9 00003006 149 rs10151731 88 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 14 00003006 069 rs12642691 110 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00003006 127 rs10112627 88 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 8 00003008 172 rs13271014 88 7 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 8 00003008 172 rs11735854 43 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00003008 075 rs4569270 110 9 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00003009 142 rs1694594 239 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00003009 068 rs1362441 67 4 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 16 0000301 075 rs10467913 44 9 logistic low creatinine clearance vs normal creatinine clearance 15 00003011 066 rs17251278 106 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 7

VO 00003013 069 rs4685409 41 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00003016 130 rs1663501 23 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 21 00003019 126 rs7315192 59 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 0000302 072 rs10114374 102 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 9 00003024 131 rs6472935 94 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00003024 137 rs9314727 65 7 logistic microalbuminuria vs no albuminuria (at entry) 9 00003024 074 rs1510699 43 4 logistic albuminuria vs no albuminuria (follow-up) 4 00003025 078 rs12702054 66 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00003026 137 rs12595945 65 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 16 00003027 068 rs4936625 117 9 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00003028 066 rs603151 26 3 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 1 00003029 139 rs6050167 48 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 20 00003031 057 rs2712875 194 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 00003033 156 rs3117598 81 4 logistic microalbuminuria vs no albuminuria (at entry) 4 00003033 133 rs610494 69 9 logistic AGE, SEX low glomerular titration rate vs control (at entry) 20 00003034 074 rs6578592 10 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 11 00003034 070 rs642783 129 8 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 4 00003036 068 rs1161262 95 2 logistic low glomerular titration rate vs control (follow-up) 4 00003037 211 rs4514740 44 0 logistic albuminuria vs no albuminuria (at entry) 17 00003037 070 rs17190154 76 4 logistic albuminuria vs no albuminuria (follow-up) 13 00003039 070

rs9819830 112 0 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 3 0000304 072 rs592228 243 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 1 0000304 071 rs16965001 81 0 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 00003041 129 rs4843568 127 3 logistic low creatinine clearance vs normal creatinine clearance 16 00003041 176 rs1396247 56 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00003041 134 rs7237496 87 2 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 18 00003042 074 rs1872292 145 0 logistic low glomerular titration rate vs control (at entry) 4 00003043 064 rs1241929 91 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 00003044 154 rs3845948 61 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00003044 136 rs1242558 91 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 14 00003045 078 rs9391062 111 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 00003045 076 rs10091527 123 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00003047 066 rs7841489 125 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00003049 057 rs9843093 119 0 logistic macroalbuminuria vs no albuminuria (at entry) 3 0000305 172 rs9639468 38 6 logistic albuminuria vs no albuminuria (follow-up) 7 00003052 145 rs10816423 112 5 logistic low creatinine clearance vs normal creatinine clearance 9 00003053 157 rs6809087 41 8 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 3 00003054 135 rs931120 131 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00003055 151 rs7516762 215 4 logistic low glomerular titration rate vs control (follow-up) 1 00003057 053 rs1968378 74 1 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 00003057 129 rs7009315 113 0 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 8 00003058 064 rs1379175 72 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00003058 144 rs6427833 214 2 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 1 00003059 141 rs7868575 6 9 logistic low creatinine clearance vs normal creatinine clearance 9 00003059 138 rs12814669 93 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00003059 073 rs2826681 14 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 21 00003059 140 rs4378283 82 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 10 00003061 034 rs259997 95 6 logistic albuminuria vs no albuminuria (follow-up) 20 00003063 134 rs221035 35 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00003063 076 rs7201164 81 0 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 00003064 127 rs808251 133 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 10 00003064 075 rs17134277 108 2 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 5 00003067 210 rs1580434 32 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00003067 057 rs11842662 45 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00003068 235 rs6780822 215 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00003068 131 rs719213 123 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00003071 069 rs8092690 117 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00003072 042 rs10511350 130 6 logistic low creatinine clearance vs normal creatinine clearance 3 00003074 159 rs2136897 44 9 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 15 00003078 069 rs3909788 125 5 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 12 00003079 072

rs1258323 69 7 logistic low glomerular titration rate vs control (at entry) 10 0000308 069 rs3111694 81 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 4 0000308 133 rs3858038 7 0 logistic low glomerular titration rate vs control (follow-up) 9 00003083 149 rs6019480 71 7 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 20 00003084 067 rs2372558 91 9 logistic low creatinine clearance vs normal creatinine clearance 14 00003086 273 rs10859609 96 9 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 00003086 033 rs10934313 130 6 logistic low creatinine clearance vs normal creatinine clearance 3 00003088 159 rs7299538 59 4 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 00003088 072 rs1965193 52 7 logistic AGE, SEX low glomerular titration rate vs control (at entry) 12 00003089 161 rs10162686 101 9 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 15 00003089 080 rs17680407 43 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00003089 075 rs2176696 42 7 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 2 00003089 063 rs16853226 178 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00003089 055 rs17805954 89 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 0000309 138 rs454356 95 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 20 00003092 158 rs6537549 69 7 logistic low glomerular titration rate vs control (follow-up) 10 00003093 144 rs16953806 71 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 00003093 069 rs17670198 804 logistic HBP microalbuminuria vs no albuminuria (at entry) 3 00003095 135 rs10233321 141 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 7 00003096 137 rs12953319 87 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00003099 073

VO rs4955814 73 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00003101 135 rs1504070 5 8 logistic AGE, SEX low glomerular titration rate vs control (at entry) 3 00003103 136 rs17594665 76 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00003103 044 rs6727239 45 0 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 2 00003104 221 rs10091527 123 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 8 00003104 060 rs973358 25 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 17 00003104 074 rs17801910 78 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 12 00003106 186 rs3735825 79 1 logistic AGE, SEX low glomerular titration rate vs control (at entry) 8 00003107 129 rs687188 129 8 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 4 00003108 067 rs10178115 158 1 logistic AGE, SEX low glomerular titration rate vs control (at entry) 2 00003108 126 rs2387573 48 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 20 00003108 057 rs1961016 43 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00003109 079 rs1002170 3 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 0000311 053 rs9287229 262 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 0000311 139 rs17753899 142 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00003111 063 rs11129937 67 0 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00003112 075 rs10890401 74 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00003112 160 rs9976697 16 3 logistic albuminuria vs no albuminuria (at entry) 21 00003113 051 rs6432155 26 0 logistic low creatinine clearance vs normal creatinine clearance 2 00003114 072 rs4716113 32 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 00003115 073

rs10495444 262 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00003117 139 rs9872164 90 2 logistic microalbuminuria or macroalbuminuria vs control (at entry) 3 00003118 067 rs41482845 186 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00003119 054 rs6427833 214 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 1 0000312 167 rs7228353 106 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 18 0000312 077 rs10248275 5 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 7 00003121 184 rs284688 57 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 19 00003123 128 rs10489185 187 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00003123 140 rs6926642 166 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 00003124 078 rs17801910 78 0 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 00003124 197 rs3909788 125 5 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 12 00003125 073 rs807525 41 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 00003125 060 rs16828691 152 1 logistic low glomerular fitration rate vs control (follow-up) 2 00003126 047 rs10956801 102 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 8 0000313 214 rs507529 62 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 13 00003131 075 rs552643 62 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 13 00003131 075 rs476179 62 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 13 00003131 075 rs7746351 166 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00003132 135 rs13204439 170 3 logistic albuminuria vs no albuminuria (follow-up) 6 00003134 070 rs8103089 99 9 logistic macroalbuminuria vs no albuminuria (at entry) 19 00003134 065 rs17736364 106 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00003134 066 rs2343468 68 6 logistic low glomerular fitration rate vs control (follow-up) 2 00003135 147 rs10898015 72 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00003136 066 rs6007450 52 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 22 00003136 062 rs1241929 91 6 logistic microalbuminuria vs no albuminuria (at entry) 14 00003137 154 rs17251278 106 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00003137 069 rs11185172 140 1 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00003138 130 rs225549 146 9 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 12 00003139 064 rs13282254 135 9 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 0000314 195 rs2781572 125 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 0000314 085 rs881018 29 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 0000314 052 rs9976697 16 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 21 00003141 051 rs3743034 38 7 logistic low glomerular fitration rate vs control (at entry) 15 00003143 147 rs4713674 46 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00003143 127 rs347558 129 6 logistic macroalbuminuria vs no albuminuria (at entry) 5 00003143 179 rs7188142 80 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 16 00003144 154 rs1545240 150 4 logistic low creatinine clearance vs normal creatinine clearance 8 00003145 069 rs9886596 22 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 8 00003145 172 rs12568218 197 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 1 00003147 071 rs16849578 152 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00003148 063

rs1364359 80 3 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00003151 134 rs1400512 79 6 logistic macroalbuminuria vs no albuminuria (at entry) 8 00003151 158 rs592228 243 5 logistic albuminuria vs no albuminuria (at entry) 1 00003152 071 rs17022224 59 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00003152 203 rs12983573 33 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 19 00003153 078 rs3844157 77 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 10 00003153 142 rs11200448 144 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00003154 139 rs7101928 27 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 00003154 150 rs11021710 17 7 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 11 00003155 073 rs11252292 8 8 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 10 00003159 133 rs1537071 34 7 logistic low creatinine clearance vs normal creatinine clearance 9 00003162 138 rs731729 134 2 logistic microalbuminuria vs no albuminuria (at entry) 7 00003163 151 rs1408478 89 2 logistic low glomerular fitration rate vs control (follow-up) 1 00003164 175 rs7982376 73 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 13 00003164 074 rs363032 26 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 20 00003166 067 rs16917529 56 0 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00003166 135 rs10114374 102 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 9 00003166 129 rs7638955 95 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 00003166 158 rs9971316 74 9 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 10 00003167 076 rs9911421 23 2 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 17 00003167 202

O O rs2826681 14 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 21 00003167 140 rs750576 206 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 2 0000317 068 rs10880112 55 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 12 00003171 138 rs9402666 136 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00003174 190 rs17428570 147 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00003175 131 rs3737150 26 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 9 00003175 132 rs1428704 130 0 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00003176 136 rs354369 81 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00003178 076 rs17648942 153 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 8 0000318 077 rs7208976 18 3 logistic microalbuminuria vs no albuminuria (at entry) 17 0000318 068 rs9487891 1186 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00003181 060 rs4377567 174 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00003182 125 rs168218 70 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 13 00003182 133 rs16853191 178 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00003182 055 rs9815517 24 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00003182 074 rs7498488 111 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 00003182 141 rs7748510 92 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00003183 146 rs7988254 73 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 13 00003184 144 rs445511 71 0 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00003185 134 rs4941199 95 7 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 18 00003187 074

rs4795164 58 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 17 00003187 125 rs4951276 217 2 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 00003187 065 rs7236575 69 1 logistic low glomerular titration rate vs control (at entry) 18 00003188 170 rs4720530 8 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00003188 074 rs4279411 166 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00003188 074 rs3108049 78 5 logistic macroalbuminuria vs no albuminuria (at entry) 7 00003189 164 rs1859875 66 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00003189 137 rs6994076 79 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 8 00003191 136 rs6886792 159 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00003191 128 rs10495829 53 5 logistic microalbuminuria vs no albuminuria (at entry) 2 00003191 214 rs644437 116 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 10 00003191 138 rs16848600 191 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00003192 050 rs257741 28 2 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00003193 150 rs468522 23 1 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 21 00003196 145 rs10495622 33 6 logistic microalbuminuria vs no albuminuria (at entry) 2 00003196 159 rs6497089 96 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 15 00003196 033 rs2829585 19 9 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 21 00003197 175 rs2912020 8 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 00003197 068 rs3113484 72 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 4 00003198 137

Ul rs3117598 81 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry)

O 4 00003198 133 rs610414 239 1 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 1 000032 146 rs3762404 244 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00003201 119 rs347559 129 6 logistic macroalbuminuria vs no albuminuria (at entry) 5 00003202 177 rs4940275 68 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00003202 068 rs6019480 71 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 20 00003202 067 rs7988254 73 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 13 00003204 138 rs4905628 120 0 logistic low creatinine clearance vs normal creatinine clearance 14 00003204 072 rs11701920 28 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 21 00003205 142 rs10998910 894 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 10 00003205 140 rs12161700 89 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 10 00003205 140 rs10823420 894 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 10 00003205 140 rs17099248 67 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 14 00003208 141 rs7135433 97 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 12 00003209 079 rs10978612 112 5 logistic low creatinine clearance vs normal creatinine clearance 9 00003209 157 rs12423492 90 3 logistic albuminuria vs no albuminuria (follow-up) 12 00003212 066 rs10000497 434 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 00003212 070 rs7695033 95 2 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 00003213 169 rs6788209 177 6 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00003214 169 rs10792617 84 9 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00003214 135 rs7970563 80 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00003214 073

rs16884604 123 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 8 00003215 061 rs3108066 78 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 00003215 162 rs4663163 245 2 logistic GE, AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 2 00003215 154 rs7916489 69 7 logistic low glomerular titration rate vs control (at entry) 10 00003216 143 rs1037537 106 5 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 18 00003217 134 rs284688 57 3 logistic albuminuria vs no albuminuria (at entry) 19 00003217 128 rs2975272 167 9 logistic albuminuria vs no albuminuria (follow-up) 8 00003218 070 rs9393366 39 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00003218 072 rs10759765 103 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00003219 074 rs2829583 19 9 logistic macroalbuminuria vs no albuminuria (at entry) 21 00003219 179 rs7111704 140 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 0000322 050 rs363035 26 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 20 00003221 068 rs11042851 15 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00003221 063 rs17428570 147 8 logistic albuminuria vs no albuminuria (at entry) 5 00003224 131 rs17071960 45 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00003226 234 rs12346176 0 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 00003226 073 rs1918026 63 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 3 00003226 138 rs2934467 121 5 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 16 00003228 127 rs7203404 58 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 16 00003228 224

Ul rs6136503 41 3 logistic albuminuria vs no albuminuria (at entry)

O 20 00003229 146 rs2503293 111 4 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (at entry) 6 00003231 076 rs149473 131 4 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00003232 165 rs10746342 93 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00003232 069 rs9300777 86 0 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 13 00003234 135 rs11158758 74 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 14 00003235 077 rs988292 19 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 21 00003236 135 rs2936534 8 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 00003237 068 rs1553953 49 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00003238 067 rs2829585 19 9 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 21 00003238 175 rs6750269 232 3 logistic low glomerular titration rate vs control (at entry) 2 0000324 058 rs7609541 232 3 logistic low glomerular titration rate vs control (at entry) 2 0000324 058 rs7570424 232 3 logistic low glomerular titration rate vs control (at entry) 2 0000324 058 rs7556846 232 3 logistic low glomerular titration rate vs control (at entry) 2 0000324 058 rs16863926 188 9 logistic microalbuminuria vs no albuminuria (at entry) 1 0000324 071 rs1161263 95 2 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 4 00003241 165 rs2292927 159 2 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 8 00003241 141 rs4713674 46 5 logistic albuminuria vs no albuminuria (follow-up) 6 00003241 127 rs9332066 45 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00003242 228 rs12602903 74 0 logistic macroalbuminuria vs no albuminuria (at entry) 17 00003244 156 rs12657171 68 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00003244 056

rs1519729 27.1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 11 0.0003244 1.34 rs2791512 118.8 logistic albuminuria vs. no albuminuria (at entry) 1 0.0003245 1.33 rs512421 66.4 logistic GE, AGE, SEX low creatinine clearance vs. normal creatinine clearance 11 0.0003246 1.39 rs7199581 27.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 16 0.0003249 0.68 rs1011275 75.3 logistic AGE, SEX albuminuria vs. no albuminuria (at entry) 2 0.0003251 0.76 rs10430114 79.7 logistic albuminuria vs. no albuminuria (follow-up) 1 0.0003251 0.73 rs16849578 152.6 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 3 0.0003251 0.63 rs3181 111.5 logistic low glomerular fitration rate vs. control (follow-up) 11 0.0003252 1.58 rs9571556 50.4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 13 0.0003252 0.76 rs10233321 141.1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 7 0.0003252 1.37 rs4239307 41.8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 18 0.0003253 1.40 rs1011275 75.3 logistic albuminuria vs. no albuminuria (at entry) 2 0.0003254 0.76 rs12471083 20.4 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 2 0.0003256 1.62 rs2031654 51.0 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 14 0.0003256 0.67 rs2093852 207.5 logistic macroalbuminuria vs. no albuminuria (at entry) 1 0.0003257 0.66 rs10510816 77.4 logistic low creatinine clearance vs. normal creatinine clearance 3 0.0003258 0.72 rs4333195 131.2 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 4 0.0003259 1.52 rs1402337 134.5 logistic MBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 12 0.0003259 1.44 rs10812364 47.2 logistic low creatinine clearance vs. normal creatinine clearance 9 0.0003261 0.71

Ul rs2113545 142.5 logistic GE, AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 7

O 0.0003261 1.52 rs17799065 156.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 7 0.0003262 0.48 rs10880112 55.6 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 12 0.0003264 1.38 rs7191101 104.7 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 16 0.0003264 1.45 rs516810 62.3 logistic GE, AGE, SEX albuminuria vs. no albuminuria (follow-up) 7 0.0003266 1.27 rs408483 29.4 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 3 0.0003266 0.70 rs7895452 29.4 logistic GE, AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 10 0.0003267 0.64 rs41388648 202.7 logistic HBP microalbuminuria vs. no albuminuria (at entry) 2 0.0003268 0.73 rs2445859 104.1 logistic albuminuria vs. no albuminuria (follow-up) 19 0.0003271 1.52 rs6866354 59.5 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 5 0.0003271 0.74 rs615031 79.1 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 8 0.0003272 1.30 rs10892549 116.2 logistic low glomerular fitration rate vs. control (follow-up) 11 0.0003272 0.68 rs408483 29.4 logistic GE, AGE, SEX low creatinine clearance vs. normal creatinine clearance 3 0.0003273 0.70 rs1542481 96.4 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 12 0.0003274 1.28 rs1149853 45.2 logistic low glomerular fitration rate vs. control (at entry) 13 0.0003276 1.46 rs6831793 198.5 logistic low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 4 0.0003277 1.34 rs10495829 53.5 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 2 0.0003277 2.14 rs4132236 82.3 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 6 0.0003278 0.76 rs2838873 54.9 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 21 0.0003279 0.71 rs12882375 44.0 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 14 0.000328 0.55 rs7035425 83.8 logistic albuminuria vs. no albuminuria (at entry) 9 0.000328 1.28

rs4131931 836 logistic low glomerular titration rate vs control (at entry) 8 00003283 060 rs4146178 561 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 9 00003284 130 rs6745998 316 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 2 00003284 162 rs10804520 130 6 logistic low creatinine clearance vs normal creatinine clearance 3 00003284 159 rs2404535 133 5 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 2 00003285 134 rs7197544 104 7 logistic microalbuminuria or microalbuminuria vs control (follow-up) 16 00003286 164 rs10233697 66 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 7 00003289 133 rs4315060 51 4 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 00003289 146 rs8086400 105 1 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 0000329 069 rs226387 19 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 12 0000329 133 rs2139148 148 1 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00003291 073 rs635409 103 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 00003291 049 rs12664845 89 6 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 6 00003292 059 rs2098242 71 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00003292 154 rs11193235 103 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 10 00003292 073 rs1509265 137 2 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 4 00003293 141 rs7414079 201 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 1 00003293 141 rs10490803 180 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00003293 064 rs1469999 111 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00003293 069

Ul rs17709552 62 2 logistic low glomerular fitration rate vs control (follow-up) 11 00003296 055

O rs4489755 115 5 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 11 00003296 075 rs11063686 12 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 00003296 133 rs7413 79 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 00003297 129 rs8094453 81 7 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 18 00003297 136 rs12512146 145 9 logistic albuminuria vs no albuminuria (follow-up) 4 00003297 129 rs7301998 59 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00003297 137 rs10070447 156 8 logistic albuminuria vs no albuminuria (at entry) 5 00003298 077 rs4771911 74 4 logistic albuminuria vs no albuminuria (at entry) 13 00003299 067 rs7123164 7 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 11 000033 062 rs6488711 31 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 000033 068 rs2396328 226 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 000033 071 rs7317235 43 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00003302 074 rs8107641 37 6 logistic low creatinine clearance vs normal creatinine clearance 19 00003304 073 rs11070279 38 4 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 15 00003305 135 rs10873499 122 6 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 14 00003305 192 rs11652482 54 1 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 17 00003305 154 rs16854563 212 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 00003305 170 rs2334063 4 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 7 00003306 077 rs7301998 59 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 12 00003306 137 rs10897118 61 4 logistic low creatinine clearance vs normal creatinine clearance 11 00003308 065

rs2075383 114 7 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 12 00003308 053 rs934609 45 1 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 2 00003309 154 rs10254929 66 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00003311 138 rs2829276 19 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 21 00003312 136 rs2113545 142 5 logistic AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 7 00003315 152 rs1118433 874 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00003316 072 rs12423492 90 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 00003318 060 rs17204962 157 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00003319 050 rs12512146 145 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00003321 129 rs17708673 65 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 7 00003321 154 rs2190963 23 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 17 00003323 213 rs17824255 20 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 3 00003324 030 rs9314727 65 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 9 00003325 074 rs753359 199 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00003326 078 rs2334063 4 4 logistic albuminuria vs no albuminuria (at entry) 7 00003329 077 rs7947110 12 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00003329 131 rs11023705 21 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00003332 079 rs2348914 141 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00003332 158 rs4142863 222 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 00003333 139

Ul rs2133774 28 6 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 16 00003333 133

O rs7123164 7 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00003333 070 rs4664865 161 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 00003333 053 rs4720530 8 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 7 00003334 074 rs7193614 107 5 logistic macroalbuminuria vs no albuminuria (at entry) 16 00003336 164 rs7248526 35 1 logistic macroalbuminuria vs no albuminuria (at entry) 19 00003337 316 rs13013563 195 1 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00003339 137 rs7193614 107 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 16 0000334 164 rs16825024 200 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 00003342 027 rs4900914 52 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 14 00003343 135 rs279259 35 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 19 00003344 212 rs279257 35 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 19 00003344 212 rs10503076 94 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 18 00003345 047 rs1563734 94 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 18 00003345 047 rs7244113 94 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 18 00003345 047 rs17070627 94 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 18 00003345 047 rs2789416 1664 logistic microalbuminuria vs no albuminuria (at entry) 1 00003345 059 rs1242558 91 2 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 00003346 077 rs6948305 121 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00003348 203 rs12973797 58 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 19 00003351 065 rs6926642 166 6 logistic albuminuria vs no albuminuria (at entry) 6 00003352 078

rs8072903 48 6 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 17 00003353 130 rs9343494 88 6 logistic low glomerular fitration rate vs control (at entry) 6 00003353 153 rs6589065 102 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00003353 186 rs2334063 4 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00003356 076 rs4771911 74 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 13 00003357 067 rs698823 66 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00003357 081 rs4881336 1 3 logistic albuminuria vs no albuminuria (at entry) 10 00003359 025 rs2900601 123 7 logistic macroalbuminuna vs no albuminuria (at entry) 9 0000336 193 rs1885290 71 6 logistic AGE, SEX microalbuminuria or macroalbuminuna vs control (at entry) 20 0000336 073 rs12795565 15 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuna vs control (follow-up) 11 0000336 061 rs2621459 101 9 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 4 00003363 151 rs13248311 141 0 logistic low glomerular fitration rate vs control (follow-up) 8 00003363 067 rs17099254 74 6 logistic microalbuminuria or macroalbuminuna vs control (follow-up) 12 00003363 068 rs6477872 103 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 9 00003364 128 rs1588213 56 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00003364 134 rs41482845 186 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuna vs control (follow-up) 3 00003365 054 rs299900 68 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 00003366 074 rs299900 68 7 logistic microalbuminuria vs no albuminuria (at entry) 5 00003367 074 rs3732979 29 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00003368 055

Ul rs17006815 47 4 logistic AGE, SEX microalbuminuria or macroalbuminuna vs control (at entry)

O 2 0000337 188 rs3950018 92 6 logistic macroalbuminuna vs no albuminuria (at entry) 13 00003371 053 rs2273120 75 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 00003371 125 rs3117598 81 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 4 00003372 133 rs1161263 95 2 logistic low glomerular fitration rate vs control (at entry) 4 00003373 203 rs2248225 19 7 logistic microalbuminuria or macroalbuminuna vs control (at entry) 21 00003375 135 rs6771260 90 4 logistic low glomerular fitration rate vs control (at entry) 3 00003376 178 rs2244676 126 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00003378 131 rs7243021 68 2 logistic microalbuminuria vs no albuminuria (at entry) 18 00003378 076 rs1730913 35 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 7 00003379 077 rs1028427 75 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 00003379 082 rs1345905 80 3 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 0000338 134 rs6114956 48 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 20 0000338 057 rs9971316 74 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 10 0000338 076 rs9383240 32 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 0000338 126 rs2318149 73 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 8 00003381 074 rs10275303 1384 logistic AGE, SEX microalbuminuria or macroalbuminuna vs control (at entry) 7 00003382 153 rs1123025 54 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 17 00003383 124 rs11023705 21 1 logistic microalbuminuria or macroalbuminuna vs control (at entry) 11 00003383 074 rs2000833 87 2 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00003384 073 rs821931 126 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 10 00003385 056

rs10743598 193 logistic AGE, SEX low glomerular titration rate vs control (at entry) 12 00003386 131 rs10867246 78 8 logistic low glomerular titration rate vs control (follow-up) 9 00003386 066 rs845729 33 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 20 00003386 077 rs610414 239 1 logistic low glomerular titration rate vs control (at entry) 1 00003387 148 rs12448211 129 0 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 00003387 135 rs10499504 27 6 logistic microalbuminuria vs no albuminuria (at entry) 7 00003387 070 rs10430114 79 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00003388 073 rs17594526 76 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00003388 044 rs2844032 60 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 11 00003391 068 rs7302315 937 logistic microalbuminuria or macroalbuminuria vs control (at entry) 12 00003391 073 rs4905630 120 1 logistic AGE, SEX low glomerular titration rate vs control (at entry) 14 00003392 070 rs4631962 9 2 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 00003392 062 rs7191101 104 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00003393 145 rs11023705 21 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00003394 074 rs664093 116 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 10 00003395 138 rs468522 23 1 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 21 00003397 145 rs2962394 163 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00003403 070 rs6730550 131 6 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 2 00003404 075 rs2791512 118 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00003404 133 rs1814538 40 1 logistic AGE, SEX low glomerular titration rate vs control (at entry) 15 00003408 144

O rs763591 80 3 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 16 00003408 152 rs17154998 120 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00003408 187 rs11233277 72 9 logistic HBP ₁ diabetes duration microalbuminuria vs no albuminuria (at entry) 11 00003409 062 rs12609410 103 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 19 00003411 151 rs1963640 29 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00003412 056 rs2014525 120 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 14 00003412 070 rs10193792 157 8 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 2 00003413 066 rs17236779 33 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 00003414 082 rs12535840 94 3 logistic macroalbuminuria vs no albuminuria (at entry) 7 00003415 152 rs16863926 188 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00003415 071 rs10503076 94 6 logistic albuminuria vs no albuminuria (at entry) 18 00003417 047 rs1563734 94 7 logistic albuminuria vs no albuminuria (at entry) 18 00003417 047 rs7244113 94 6 logistic albuminuria vs no albuminuria (at entry) 18 00003417 047 rs17070627 94 7 logistic albuminuria vs no albuminuria (at entry) 18 00003417 047 rs246277 130 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 0000342 157 rs3804775 117 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 00003421 129 rs996492 123 6 logistic macroalbuminuria vs no albuminuria (at entry) 9 00003421 157 rs988026 86 6 logistic AGE, SEX low glomerular titration rate vs control (at entry) 13 00003422 161 rs11156316 111 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 00003422 076 rs4720530 86 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00003423 074

rs4983073 22 9 logistic low glomerular fitration rate vs control (follow-up) 14 00003424 170 rs644798 104 5 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 18 00003425 064 rs731729 134 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00003425 151 rs12599351 124 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 16 00003425 075 rs1514417 17 9 logistic low glomerular fitration rate vs control (at entry) 21 00003426 164 rs6822958 131 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 4 00003426 149 rs2825233 10 2 logistic albuminuria vs no albuminuria (follow-up) 21 00003426 062 rs10774823 125 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00003428 127 rs35424097 182 9 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00003428 138 rs12685939 65 8 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 9 00003429 164 rs408510 71 8 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 00003431 068 rs2503293 111 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00003431 077 rs16938800 94 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 8 00003431 164 rs10751020 84 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 11 00003431 075 rs942989 43 1 logistic microalbuminuria vs no albuminuria (at entry) 20 00003431 260 rs16994846 53 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 22 00003431 029 rs11177698 81 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00003432 233 rs17056214 47 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 13 00003433 203 rs7982376 73 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00003433 074 rs171500 33 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 20 00003434 130

O OC rs10884350 126 7 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00003435 139 rs17099262 67 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 14 00003435 140 rs11696281 48 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 20 00003436 057 rs2404535 133 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00003437 134 rs10233697 66 3 logistic albuminuria vs no albuminuria (at entry) 7 00003439 133 rs4430153 65 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00003441 162 rs2789416 166 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00003443 059 rs8072903 48 6 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 17 00003446 130 rs259997 95 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 20 00003446 134 rs17509991 76 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00003446 040 rs11121778 25 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00003448 050 rs10956801 102 7 logistic HBP ₁ diabetes duration microalbuminuria vs no albuminuria (at entry) 8 00003448 214 rs6921316 30 2 logistic low glomerular titration rate vs control (at entry) 6 00003449 155 rs2194349 80 3 logistic low glomerular fitration rate vs control (at entry) 16 00003449 150 rs2975272 167 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00003449 070 rs3114081 72 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 4 0000345 137 rs16825024 200 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 0000345 027 rs17622224 165 1 logistic low glomerular titration rate vs control (at entry) 4 00003452 051 rs7559347 119 5 logistic low glomerular titration rate vs control (follow-up) 2 00003452 145 rs7082705 102 7 logistic albuminuria vs no albuminuria (follow-up) 10 00003452 131

rs 12485415 42 4 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00003453 246 rs41420549 79 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 00003454 130 rs4777205 70 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 15 00003459 071 rs6728947 171 8 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 0000346 064 rs4964292 112 5 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 12 00003461 185 rs3753305 187 5 logistic albuminuria vs no albuminuria (at entry) 1 00003462 078 rs7161611 6 5 logistic low glomerular fitration rate vs control (follow-up) 14 00003463 065 rs2503293 111 4 logistic albuminuria vs no albuminuria (follow-up) 6 00003463 077 rs4276176 90 2 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 3 00003463 066 rs17011370 94 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00003466 197 rs2235757 98 0 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 20 00003466 149 rs10231343 66 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00003467 138 rs28891 130 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 00003467 156 rs2846072 78 1 logistic low creatinine clearance vs normal creatinine clearance 11 00003468 185 rs17011370 94 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00003469 197 rs257654 103 2 logistic macroalbuminuria vs no albuminuria (at entry) 19 0000347 152 rs4508971 110 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00003471 128 rs17480167 122 5 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 00003473 071 rs 11024782 21 8 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00003473 074 rs12120893 127 4 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00003474 155 rs550523 26 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 00003475 159 rs35424097 182 9 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 00003476 137 rs2194325 80 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 16 00003476 152 rs11640993 67 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 16 00003477 133 rs7281608 17 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 21 0000348 157 rs9976697 16 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 21 00003481 051 rs1913695 58 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 12 00003482 135 rs11888061 83 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00003482 071 rs9834708 112 2 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00003485 069 rs11023705 21 1 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00003485 076 rs7035425 838 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 9 0000349 128 rs12713469 81 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 0000349 127 rs1416641 89 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 6 00003491 053 rs17487422 38 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 14 00003491 143 rs12512146 145 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00003493 129 rs443543 71 0 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00003494 133 rs7723199 7 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00003494 141 rs1344361 148 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 00003495 434 rs1975980 48 8 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 17 00003496 138 rs3743033 38 7 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 15 00003496 139

rs1400510 79 6 logistic macroalbuminuπa vs no albuminuria (at entry) 8 00003496 157 rs978255 79 6 logistic macroalbuminuπa vs no albuminuria (at entry) 8 00003496 157 rs1857967 227 3 logistic low glomerular Titration rate vs normal glom filtration rate (follow-up) 1 00003497 140 rs7807871 142 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 7 00003498 131 rs11063686 12 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 00003499 133 rs10851396 384 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 15 000035 149 rs809213 144 2 logistic albuminuria vs no albuminuria (at entry) 3 00003501 064 rs7854466 61 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 9 00003501 127 rs12346176 0 9 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 9 00003502 073 rs2967793 141 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00003502 075 rs7272436 81 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 20 00003502 034 rs6774426 25 7 logistic GE ₁ AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00003505 127 rs2144825 132 4 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 14 00003505 141 rs10519362 133 6 logistic low creatinine clearance vs normal creatinine clearance 4 00003505 146 rs10166268 148 1 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00003506 077 rs9675700 87 3 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00003507 075 rs6136503 41 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 20 00003507 146 rs4873692 67 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 8 00003507 081 rs1694594 239 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 00003507 068

Ul rs151052 69 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 20 00003508 148

O rs1986877 55 3 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 7 00003509 077 rs562966 116 2 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 11 00003509 145 rs1533931 129 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 3 00003511 122 rs11070279 38 4 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 15 00003511 148 rs17680905 43 3 logistic albuminuria vs no albuminuria (follow-up) 4 00003512 075 rs16896723 74 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 00003512 155 rs4571397 660 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00003512 138 rs9424612 248 3 logistic macroalbuminuria vs no albuminuria (at entry) 1 00003513 064 rs648638 116 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 10 00003514 138 rs4496808 32 8 logistic albuminuria vs no albuminuria (follow-up) 6 00003515 129 rs6717050 189 8 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00003515 121 rs4422395 81 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 4 00003515 145 rs6472341 83 6 logistic low glomerular fitration rate vs control (at entry) 8 00003517 060 rs6999595 83 6 logistic low glomerular fitration rate vs control (at entry) 8 00003517 060 rs4412353 83 6 logistic low glomerular fitration rate vs control (at entry) 8 00003517 060 rs9969560 83 6 logistic low glomerular fitration rate vs control (at entry) 8 00003517 060 rs2930040 79 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 00003518 129 rs10071774 68 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 00003518 065 rs11951359 68 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 00003518 065 rs7977693 96 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 12 00003519 139

rs4381737 248 2 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00003519 150 rs7973993 112 5 logistic AGE, SEX low glomerular titration rate vs control (at entry) 12 00003521 179 rs962314 126 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00003521 131 rs2244671 126 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00003521 131 rs2255590 126 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00003521 131 rs12000827 65 5 logistic macroalbuminuria vs no albuminuria (at entry) 9 00003522 219 rs10455038 130 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 00003522 134 rs10155009 96 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 3 00003523 061 rs6455209 82 3 logistic albuminuria vs no albuminuria (follow-up) 6 00003523 068 rs3856447 19 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00003523 073 rs8073228 48 6 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 17 00003524 136 rs17708673 65 3 logistic low glomerular titration rate vs control (follow-up) 7 00003525 170 rs7913419 34 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 10 00003525 082 rs6518240 55 1 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 21 00003526 145 rs41391845 71 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 00003526 174 rs11160417 119 8 logistic low creatinine clearance vs normal creatinine clearance 14 00003531 139 rs6959108 20 0 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00003531 075 rs10743140 15 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00003532 052 rs12603115 64 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 17 00003533 128

Ul rs3852016 177 6 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00003535 169 rs6546626 88 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 00003537 076 rs7590007 29 4 logistic albuminuria vs no albuminuria (follow-up) 2 00003538 135 rs7847215 61 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 9 00003538 127 rs17345786 117 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00003538 131 rs2283092 129 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 7 00003538 148 rs10045387 129 6 logistic macroalbuminuria vs no albuminuria (at entry) 5 00003539 177 rs880716 364 logistic low glomerular titration rate vs control (follow-up) 15 0000354 146 rs7874519 56 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 0000354 134 rs2551677 126 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 0000354 132 rs7750426 166 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 0000354 073 rs215759 65 4 logistic low glomerular titration rate vs control (follow-up) 1 00003544 166 rs4315060 51 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00003544 125 rs10116752 102 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 9 00003546 129 rs3111694 81 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 4 00003546 133 rs11743536 159 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 00003546 153 rs7229063 109 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 18 00003547 130 rs3874517 80 3 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 16 00003551 133 rs2840588 166 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00003551 058 rs17221260 0 8 logistic AGE, SEX low glomerular titration rate vs control (at entry) 10 00003552 079 rs12944499 12 7 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 17 00003552 150

rs11848645 37 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 14 00003554 138 rs17747233 103 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 8 00003554 062 rs1054497 174 7 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00003555 126 rs4420537 38 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 16 00003557 166 rs2953310 49 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 00003559 150 rs2321816 165 1 logistic low glomerular fitration rate vs control (at entry) 4 0000356 050 rs7611310 130 0 logistic albuminuria vs no albuminuria (at entry) 3 0000356 128 rs130250 31 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 22 00003561 070 rs2851912 41 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00003563 074 rs2851911 41 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00003563 074 rs2849395 41 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00003563 074 rs2131887 239 9 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00003564 074 rs1986877 55 3 logistic low glomerular titration rate vs control (follow-up) 7 00003565 069 rs4456715 131 7 logistic low glomerular titration rate vs control (at entry) 2 00003567 068 rs4685409 41 8 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 3 00003568 151 rs4610242 43 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 3 00003568 071 rs1673887 118 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00003569 061 rs7308867 84 7 logistic microalbuminuria vs no albuminuria (at entry) 12 00003571 071 rs955051 119 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00003572 148

Ul rs3104704 17 6 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 16 00003574 142 rs13333226 38 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00003574 066 rs2826684 14 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 21 00003576 140 rs1149851 45 2 logistic low glomerular titration rate vs control (at entry) 13 00003577 146 rs4128841 251 2 logistic low glomerular titration rate vs control (at entry) 1 0000358 144 rs16825771 226 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 0000358 069 rs17168478 141 1 logistic microalbuminuria vs no albuminuria (at entry) 7 0000358 152 rs8057668 80 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 16 00003581 124 rs781731 124 4 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 00003581 159 rs7921561 116 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 10 00003581 139 rs4771911 74 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 13 00003582 067 rs2826684 14 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 21 00003583 140 rs445511 71 0 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 5 00003584 134 rs4881336 1 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 10 00003584 025 rs7308867 84 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00003584 071 rs13354373 164 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 00003584 126 rs6697315 984 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00003585 066 rs10872387 130 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 00003585 076 rs1047799 44 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 17 00003586 078 rs4936235 148 0 logistic albuminuria vs no albuminuria (follow-up) 11 00003587 159 rs642783 129 8 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 4 00003589 068

rs259994 956 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 20 00003591 222 rs17767946 46 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00003591 137 rs1861619 202 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 2 00003594 076 rs986866 43 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00003594 078 rs11185172 140 1 logistic microalbuminuria vs no albuminuria (at entry) 1 00003594 130 rs4060121 159 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 8 00003597 147 rs4985702 44 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 17 00003598 073 rs28490018 114 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 14 000036 055 rs7111704 140 8 logistic albuminuria vs no albuminuria (at entry) 11 000036 054 rs1161262 95 2 logistic low glomerular fitration rate vs control (at entry) 4 00003602 201 rs2387573 48 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 20 00003602 057 rs11023705 21 1 logistic albuminuria vs no albuminuria (at entry) 11 00003603 079 rs12002851 99 5 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 9 00003604 178 rs688808 129 8 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 00003605 068 rs6728947 171 8 logistic macroalbuminuπa vs no albuminuria (at entry) 2 00003605 064 rs7185053 27 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 16 00003605 069 rs4497678 110 5 logistic low glomerular fitration rate vs control (follow-up) 16 0000361 146 rs2907334 6 6 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 19 00003611 064 rs11630273 38 4 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 15 00003613 070

Ul rs7505507 68 4 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00003614 076 rs3821374 63 4 logistic low glomerular fitration rate vs control (follow-up) 3 00003616 161 rs304207 84 4 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 3 00003616 075 rs12130167 162 2 logistic albuminuria vs no albuminuria (follow-up) 1 00003616 129 rs1979096 27 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 7 00003616 068 rs16938800 94 1 logistic macroalbuminuria vs no albuminuria (at entry) 8 00003617 164 rs16837766 261 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00003619 066 rs17006815 47 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 2 00003619 188 rs17105368 147 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 10 0000362 177 rs7911998 147 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 10 0000362 177 rs1434727 97 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 12 00003621 080 rs10814269 0 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 9 00003621 076 rs1482047 102 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00003623 161 rs11070285 38 5 logistic low glomerular fitration rate vs control (follow-up) 15 00003624 146 rs522740 94 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00003624 137 rs1962196 41 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00003625 075 rs720727 71 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 20 00003625 073 rs4569824 110 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00003626 127 rs2730306 20 0 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 00003626 162 rs10851396 38 4 logistic low glomerular fitration rate vs control (follow-up) 15 00003627 149 rs4548801 128 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 14 00003627 139

rs31899 225 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00003628 157 rs955051 119 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 11 00003628 148 rs6427833 214 2 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00003629 141 rs10114374 102 8 logistic albuminuria vs no albuminuria (at entry) 9 00003631 131 rs16988954 55 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 20 00003631 181 rs1979096 27 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00003632 068 rs281243 44 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 15 00003633 130 rs7748510 92 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 00003633 146 rs7207189 74 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 17 00003634 125 rs11888061 83 7 logistic low glomerular fitration rate vs control (follow-up) 2 00003635 063 rs10495622 33 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00003637 159 rs9383240 32 8 logistic albuminuria vs no albuminuria (follow-up) 6 00003638 129 rs357897 69 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00003638 152 rs16952615 104 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 16 0000364 244 rs1932604 74 5 logistic microalbuminuria vs no albuminuria (at entry) 10 0000364 068 rs9888275 22 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 0000364 064 rs1389798 93 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 12 00003642 073 rs4269885 97 8 logistic low glomerular fitration rate vs control (follow-up) 11 00003643 146 rs4923872 38 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 15 00003643 145

Ul rs7317235 43 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 13 00003645 074 rs11185172 140 1 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00003647 130 rs726820 106 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 7 00003648 141 rs1400505 79 6 logistic macroalbuminuria vs no albuminuria (at entry) 8 00003648 157 rs1202201 34 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 00003648 142 rs6553089 204 9 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 0000365 080 rs2839580 49 8 logistic albuminuria vs no albuminuria (at entry) 21 0000365 078 rs2620772 78 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 12 00003652 074 rs12775879 132 0 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00003654 177 rs10091527 123 8 logistic low glomerular fitration rate vs control (at entry) 8 00003655 063 rs6050183 48 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 20 00003656 057 rs6050164 48 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 20 00003656 057 rs7264679 48 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 20 00003656 057 rs6050170 48 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 20 00003656 057 rs6106974 48 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 20 00003656 057 rs4285402 151 2 logistic low glomerular fitration rate vs control (at entry) 7 00003658 061 rs4496808 32 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00003658 129 rs6817612 145 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00003658 128 rs9523996 72 5 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00003658 158 rs733508 178 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 3 00003658 072 rs942989 43 1 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 20 00003661 260

rs11119981 221 9 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00003663 149 rs9314727 65 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 9 00003663 074 rs4372536 62 4 logistic low creatinine clearance vs normal creatinine clearance 12 00003664 138 rs4739079 800 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 8 00003664 074 rs10493750 116 2 logistic low creatinine clearance vs normal creatinine clearance 1 00003665 073 rs3950018 92 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00003665 053 rs9285201 45 9 logistic low glomerular fitration rate vs control (follow-up) 13 00003666 149 rs7516762 215 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00003667 062 rs7910212 16 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 10 00003668 143 rs9383240 32 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00003669 129 rs1571567 103 6 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 9 0000367 076 rs550523 26 3 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00003671 140 rs4260776 113 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00003671 077 rs1379666 88 6 logistic low glomerular fitration rate vs control (at entry) 6 00003672 153 rs10499504 27 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00003672 070 rs2642849 78 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00003673 076 rs2334063 4 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00003676 076 rs16889712 124 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 00003676 163 rs1999717 18 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00003676 070

Ul rs8047864 18 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 16 0000368 196 rs4985702 44 2 logistic microalbuminuria vs no albuminuria (at entry) 17 0000368 071 rs1532554 8 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 8 0000368 071 rs2009111 22 7 logistic low glomerular fitration rate vs control (at entry) 22 00003681 064 rs9498737 103 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 6 00003682 130 rs1894898 67 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 16 00003683 135 rs7651436 68 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00003683 211 rs4131931 836 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 00003684 063 rs1416641 89 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 6 00003685 055 rs10922207 204 5 logistic low creatinine clearance vs normal creatinine clearance 1 00003685 223 rs41338847 147 8 logistic albuminuria vs no albuminuria (at entry) 5 00003685 131 rs1356952 134 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 00003686 144 rs1490319 56 0 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00003687 133 rs12965571 41 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 00003687 141 rs1218661 262 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00003689 130 rs8098626 68 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 0000369 074 rs41338847 147 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 0000369 131 rs8056052 67 3 logistic low glomerular fitration rate vs control (at entry) 16 00003691 146 rs6997147 96 9 logistic albuminuria vs no albuminuria (follow-up) 8 00003691 078 rs16919323 105 4 logistic microalbuminuria or macroalbuminuria vs control (at entry) 9 00003691 239 rs1933002 239 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00003691 076

rs7916489 69 7 logistic low glomerular titration rate vs control (follow-up) 10 00003692 143 rs10166268 148 1 logistic microalbuminuria vs no albuminuria (at entry) 2 00003692 077 rs11781914 37 6 logistic microalbuminuria or microalbuminuria vs control (follow-up) 8 00003692 138 rs10743598 19 3 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 12 00003694 131 rs6081676 43 0 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 20 00003694 271 rs1935733 88 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 00003694 050 rs4811684 85 6 logistic macroalbuminuria vs no albuminuria (at entry) 20 00003695 066 rs592228 243 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00003696 071 rs9309308 45 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 2 00003698 149 rs4712300 33 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 00003699 066 rs3740293 93 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 10 000037 073 rs33962847 48 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 17 00003701 137 rs6861743 108 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 5 00003702 212 rs17021754 146 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00003702 035 rs1980239 38 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 4 00003702 123 rs10514479 104 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 16 00003703 192 rs7611310 130 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 3 00003704 128 rs6977739 98 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 7 00003705 159 rs6497089 96 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 15 00003705 035 rs41338847 147 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00003705 131 rs6997147 96 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00003706 078 rs16887282 124 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 8 00003706 361 rs1940893 93 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 6 00003707 143 rs2062099 95 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00003708 187 rs11781914 37 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00003709 138 rs970022 145 9 logistic albuminuria vs no albuminuria (follow-up) 4 00003711 128 rs7590007 29 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00003711 135 rs16953054 74 0 logistic macroalbuminuria vs no albuminuria (at entry) 17 00003711 155 rs171500 33 0 logistic albuminuria vs no albuminuria (follow-up) 20 00003712 130 rs7973993 112 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 12 00003714 217 rs347558 129 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00003714 179 rs11848645 37 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 14 00003715 136 rs4334629 41 8 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00003716 074 rs4403634 222 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 1 00003716 140 rs6773962 173 6 logistic macroalbuminuria vs no albuminuria (at entry) 3 00003716 152 rs1026847 56 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00003718 134 rs7130460 22 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00003718 065 rs931120 131 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00003719 137 rs4600972 135 6 logistic microalbuminuria vs no albuminuria (at entry) 4 00003721 148 rs10489628 99 4 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 1 00003722 078

rs7653303 130 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 00003722 136 rs7406339 48 6 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 17 00003723 133 rs1555157 48 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 20 00003723 059 rs10765796 93 3 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 11 00003723 075 rs745165 107 0 logistic low glomerular fitration rate vs control (at entry) 20 00003725 182 rs7577717 193 0 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 00003725 197 rs9391062 111 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00003726 076 rs4440442 82 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00003728 075 rs304209 84 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 3 00003729 071 rs4789188 101 5 logistic low glomerular titration rate vs control (at entry) 17 0000373 156 rs2263643 126 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 0000373 130 rs2840588 166 4 logistic albuminuria vs no albuminuria (at entry) 1 00003731 058 rs1571567 103 6 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00003735 075 rs16846031 242 0 logistic low creatinine clearance vs normal creatinine clearance 1 00003736 178 rs6124066 99 8 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 20 00003736 057 rs17024965 102 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 4 00003736 072 rs7193007 49 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 16 00003737 144 rs4535211 41 8 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 3 00003738 135 rs7590007 29 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00003738 151

Ul rs7146217 74 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 14 0000374 127 rs5010979 10 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 11 0000374 071 rs281243 44 9 logistic albuminuria vs no albuminuria (follow-up) 15 00003741 130 rs2203661 79 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 8 00003741 160 rs2838964 55 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 21 00003742 181 rs515603 31 2 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 1 00003743 073 rs4321205 38 9 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 16 00003744 074 rs4280249 38 9 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00003744 074 rs4369676 38 9 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 16 00003744 074 rs17146098 129 6 logistic macroalbuminuria vs no albuminuria (at entry) 5 00003744 177 rs17641512 40 1 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 13 00003746 066 rs157352 159 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00003747 129 rs10509870 127 5 logistic low glomerular titration rate vs control (at entry) 10 0000375 050 rs651009 102 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 9 0000375 055 rs7334517 40 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 13 00003751 066 rs12590483 52 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 14 00003755 133 rs2833995 30 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 21 00003755 130 rs7708902 59 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 5 00003756 073 rs733508 178 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00003757 072 rs10510816 77 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00003759 072 rs7651436 68 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00003759 211

rs7237496 87 2 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 18 0000376 074 rs1571317 29 6 logistic AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 13 0000376 151 rs26217 26 2 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 0000376 171 rs2157329 54 9 logistic low creatinine clearance vs normal creatinine clearance 22 00003761 137 rs9821016 25 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00003761 066 rs17154458 35 6 logistic low creatinine clearance vs normal creatinine clearance 10 00003763 161 rs10894321 137 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00003763 076 rs6041325 32 6 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 00003764 134 rs2841941 251 3 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00003766 127 rs7229063 109 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 18 00003766 146 rs10781448 77 1 logistic low glomerular fitration rate vs control (at entry) 9 00003767 144 rs6751830 202 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00003767 074 rs1548445 37 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 16 00003769 157 rs7847215 61 2 logistic albuminuria vs no albuminuria (follow-up) 9 00003769 127 rs6750269 232 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 00003771 058 rs7609541 232 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 00003771 058 rs7570424 232 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 00003771 058 rs7556846 232 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 00003771 058 rs2248922 262 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00003774 129

Ul rs2468244 94 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00003775 065

OO rs809213 144 2 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 3 00003776 064 rs12192108 130 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 00003776 076 rs17737516 71 4 logistic AGE ₁ SEX low glomerular fitration rate vs control (at entry) 15 00003777 068 rs7136397 59 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 12 00003777 150 rs2804085 45 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00003777 236 rs245820 145 8 logistic low glomerular fitration rate vs control (at entry) 5 00003778 064 rs8000282 76 3 logistic microalbuminuria vs no albuminuria (at entry) 13 00003778 155 rs2839580 49 8 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 21 0000378 078 rs2988011 61 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 9 0000378 127 rs11853308 6 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 15 0000378 073 rs6948305 121 3 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 7 00003784 223 rs7237496 87 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00003784 071 rs951534 125 3 logistic GE ₁ AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00003786 086 rs702605 60 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00003786 081 rs10982428 123 0 logistic HBP microalbuminuria vs no albuminuria (at entry) 9 00003787 152 rs17171382 141 4 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00003788 151 rs6955265 151 1 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 00003788 073 rs3917768 187 5 logistic low glomerular fitration rate vs control (follow-up) 1 00003789 147 rs12257494 73 8 logistic albuminuria vs no albuminuria (follow-up) 10 00003789 076 rs2825233 10 2 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 21 00003789 062

rs42814 60 9 logistic microalbuminuria vs no albuminuria (at entry) 2 0 0003789 0 77 rs11121778 25 1 logistic macroalbuminuria vs no albuminuria (at entry) 1 0 0003792 0 50 rs11037175 53 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 0 0003792 0 73 rs4296321 41 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00003792 1 40 rs7035425 83 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 9 0 0003793 1 28 rs4076277 170 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 7 0 0003794 4 72 rs10280940 170 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 7 0 0003794 4 72 rs1061860 215 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 0 0003794 1 29 rs1031287 49 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 18 0 0003795 0 70 rs11132476 204 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 4 0 0003795 1 29 rs1912278 106 3 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 10 0 0003796 1 65 rs 1932604 74 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 10 0 0003797 0 68 rs 1546640 79 6 logistic macroalbuminuria vs no albuminuria (at entry) 8 0 0003798 1 57 rs465576 46 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 21 0 0003802 7 79 rs10248305 664 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 0 0003802 1 38 rs17680407 43 3 logistic albuminuria vs no albuminuria (at entry) 4 0 0003803 0 75 rs244885 118 1 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 16 0 0003804 1 71 rs9857723 117 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 0 0003804 1 27 rs2862907 10 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 13 0 0003804 1 43 _y , rs17071349 90 4 logistic low glomerular fitration rate vs control (at entry) 3 0 0003805 1 78

S rs1472095 36 5 logistic microalbuminuria vs no albuminuria (at entry) 4 0 0003805 1 34 rs298182 81 0 logistic low glomerular fitration rate vs control (at entry) 8 0 0003808 0 48 rs11940741 207 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 4 0 0003808 1 57 rs1729975 114 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 0 000381 1 50 rs10259269 66 3 logistic microalbuminuria vs no albuminuria (at entry) 7 0 0003811 1 36 rs7238071 125 1 logistic albuminuria vs no albuminuria (at entry) 18 0 0003812 1 31 rs10248275 5 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 0 0003812 2 01 rs2394999 44 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 0 0003813 1 54 rs7308867 84 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 0 0003815 0 71 rs2404535 133 5 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 2 0 0003816 1 38 rs4923872 38 3 logistic low glomerular fitration rate vs control (follow-up) 15 0 0003817 1 45 rs3846116 34 1 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 0 0003818 1 37 rs17411195 105 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 1 0 0003818 0 73 rs7653379 177 4 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 0 0003818 0 63 rs7243021 68 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 18 0 0003818 0 76 rs4279411 166 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 6 0 0003819 0 79 rs3790990 252 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 0 000382 1 44 rs225487 146 8 logistic low glomerular fitration rate vs control (follow-up) 12 0 0003821 0 68 rs2934467 121 5 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 16 0 0003821 1 26 rs7123971 98 2 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 0 0003824 3 53

rs4528272 132 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 10 00003825 151 rs 10803476 31 4 logistic albuminuria vs no albuminuria (follow-up) 1 00003826 078 rs881018 29 5 logistic macroalbuminuria vs no albuminuria (at entry) 6 00003827 052 rs4657486 177 4 logistic AGE, SEX low glomerular Titration rate vs normal glom filtration rate (follow-up) 1 00003829 129 rs11119552 229 7 logistic microalbuminuria vs no albuminuria (at entry) 1 0000383 134 rs 1865977 84 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 16 00003831 078 rs10471462 68 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 00003834 065 rs6582 38 4 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 15 00003836 134 rs11081564 125 0 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 18 00003836 133 rs2241152 55 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 7 00003837 174 rs1637931 244 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00003838 069 rs17120305 51 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 00003838 070 rs733508 178 9 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00003838 072 rs7988254 73 8 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 13 0000384 138 rs6760957 119 6 logistic low creatinine clearance vs normal creatinine clearance 2 00003841 136 rs2242722 34 2 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 21 00003842 195 rs7199581 27 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 00003842 068 rs12511845 132 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00003842 067 rs4141372 31 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 00003842 073

Ul rs1472095 36 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00003843 137

K>

O rs7685386 135 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 4 00003843 081 rs7197544 104 7 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 16 00003844 142 rs4580841 82 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00003844 076 rs9995738 128 8 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00003845 130 rs10498537 89 1 logistic AGE ₁ SEX low glomerular fitration rate vs control (at entry) 14 00003846 069 rs709934 239 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00003846 148 rs17272796 41 8 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00003847 134 rs35774871 77 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 17 00003847 149 rs6499142 67 4 logistic AGE ₁ SEX low glomerular fitration rate vs control (at entry) 16 00003849 072 rs4873713 67 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 8 00003849 082 rs226408 19 3 logistic AGE ₁ SEX low glomerular fitration rate vs control (at entry) 12 00003851 132 rs17053174 124 8 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs control (follow-up) 6 00003851 173 rs7977693 96 0 logistic albuminuria vs no albuminuria (at entry) 12 00003851 139 rs698823 66 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 00003851 081 rs11204592 288 5 logistic low glomerular fitration rate vs control (at entry) 1 00003852 153 rs1603530 75 1 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00003853 071 rs11857247 38 4 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 15 00003853 136 rs7807871 142 5 logistic albuminuria vs no albuminuria (at entry) 7 00003853 131 rs157676 159 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00003855 129 rs1379666 88 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 6 00003856 153

rs7982077 18 0 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 13 00003856 070 rs11177698 81 1 logistic albuminuria vs no albuminuria (follow-up) 12 00003858 233 rs12814669 93 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 12 00003858 073 rs1428704 130 0 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 5 00003859 136 rs970022 145 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00003859 128 rs715975 806 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 9 00003859 076 rs10773982 2 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 12 0000386 124 rs8073228 48 6 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 17 00003863 133 rs6809087 41 8 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00003864 135 rs10495244 242 2 logistic low creatinine clearance vs normal creatinine clearance 1 00003864 147 rs11027539 30 1 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 11 00003865 153 rs9561658 73 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 13 00003867 136 rs6891838 157 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00003867 080 rs1035897 131 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00003867 131 rs651009 102 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 9 00003867 055 rs10743140 15 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 11 00003867 052 rs2354324 68 0 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 14 00003869 141 rs4712300 33 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 0000387 068 rs12545592 83 6 logistic low glomerular fitration rate vs control (at entry) 8 00003871 060 rs10967935 49 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 9 00003871 067 rs360089 242 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 1 00003871 144 rs8121916 32 6 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 00003872 134 rs1430373 87 2 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00003872 134 rs10254929 66 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00003872 138 rs443543 71 0 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00003873 133 rs12030639 218 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 1 00003874 079 rs702604 60 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00003874 081 rs243839 73 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 00003874 152 rs1872829 53 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00003875 131 rs1655131 167 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 10 00003875 076 rs1218661 262 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 00003875 135 rs2171304 7 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 10 00003876 069 rs2532660 137 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00003877 130 rs347559 1296 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00003877 177 rs10499504 27 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00003877 068 rs1362441 67 4 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 00003878 073 rs2406198 116 1 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 18 00003878 071 rs11647459 67 3 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 00003879 137 rs1344484 67 3 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 00003879 137 rs1344485 67 3 logistic AGE, SEX low glomerular titration rate vs control (at entry) 16 00003879 137

rs10000497 434 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 0000388 078 rs11648875 104 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00003882 156 rs7967892 58 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00003884 137 rs12405120 116 2 logistic low creatinine clearance vs normal creatinine clearance 1 00003885 073 rs17097633 61 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 12 00003885 169 rs4027132 27 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00003885 074 rs7847215 61 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 9 00003886 127 rs12602903 74 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 17 00003888 156 rs4964292 112 5 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 12 00003889 211 rs1459375 151 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00003889 132 rs6790634 181 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 00003889 081 rs17763040 25 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 13 00003889 065 rs4569270 110 9 logistic GE, AGE, SEX low glomerular Titration rate vs normal glom filtration rate (follow-up) 16 00003891 142 rs9639468 38 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 7 00003891 145 rs2471533 94 4 logistic albuminuria vs no albuminuria (follow-up) 12 00003892 064 rs7133648 10 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 00003893 072 rs4420537 38 6 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 16 00003894 166 rs9696488 0 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 9 00003894 078 rs7199114 9 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00003894 067 rs2842754 222 0 logistic GE ₁ AGE ₁ SEX low glomerular Titration rate vs control (at entry) 1 00003896 165

K> K) rs10107785 796 logistic macroalbuminuria vs no albuminuria (at entry) 8 00003896 157 rs10738743 46 3 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 9 00003897 074 rs2900601 123 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 00003897 193 rs902126 138 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00003897 073 rs2934467 121 5 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 16 00003898 127 rs6102795 57 8 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 20 00003898 069 rs7047479 61 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 9 00003898 127 rs1428704 130 0 logistic low glomerular Titration rate vs normal glom filtration rate (follow-up) 5 000039 136 rs4584771 96 9 logistic albuminuria vs no albuminuria (follow-up) 15 00003902 077 rs7238071 125 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 18 00003903 131 rs4643103 84 9 logistic low glomerular titration rate vs control (follow-up) 11 00003904 157 rs4936618 117 8 logistic low glomerular titration rate vs control (at entry) 11 00003905 060 rs12346176 0 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 9 00003905 077 rs7764326 164 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00003906 139 rs7199114 9 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 00003907 067 rs10859609 96 9 logistic macroalbuminuria vs no albuminuria (at entry) 12 00003908 033 rs937525 134 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00003909 138 rs9675700 87 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 0000391 071 rs4658507 273 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 0000391 064 rs7070694 75 3 logistic low glomerular titration rate vs control (at entry) 10 00003911 052

rs11648875 104.7 logistic AGE, SEX albuminuria vs. no albuminuria (follow-up) 16 0.0003911 1.43 rs10501293 53.8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 11 0.0003911 1.33 rs2227127 45.7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 6 0.0003912 1.33 rs902891 159.6 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 12 0.0003913 1.39 rs12257494 73.8 logistic AGE, SEX albuminuria vs. no albuminuria (follow-up) 10 0.0003913 0.76 rs6050167 48.8 logistic GE, AGE, SEX low glomerular fitration rate vs. control (follow-up) 20 0.0003914 0.57 rs17099250 67.6 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 14 0.0003914 1.39 rs6127813 86.1 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 20 0.0003916 0.71 rs7765427 91.2 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 6 0.0003917 1.69 rs10858753 94.5 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 12 0.0003919 1.58 rs2269252 96.7 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 1 0.0003919 1.44 rs6673069 75.1 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 1 0.000392 0.72 rs1510294 123.7 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 6 0.000392 1.23 rs11042851 15.9 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 11 0.0003923 0.63 rs2013004 48.0 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 9 0.0003924 1.36 rs4367362 82.3 logistic GE, AGE, SEX microalbuminuria vs. no albuminuria (at entry) 6 0.0003924 0.75 rs781730 124.4 logistic GE, AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 6 0.0003925 1.58 rs1254947 149.2 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 10 0.0003926 1.32 rs16953806 71.4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 16 0.0003926 0.69 rs4947696 73.3 logistic low creatinine clearance vs. normal creatinine clearance 7 0.0003927 0.70 rs1077776 117.2 logistic HBP microalbuminuria vs. no albuminuria (at entry) 1 0.0003928 1.59 rs2730306 20.0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 3 0.000393 2.20 rs41435651 93.3 logistic low creatinine clearance vs. normal creatinine clearance 14 0.000393 2.33 rs16887282 124.3 logistic AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 8 0.0003931 3.61 rs11027538 30.1 logistic AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 11 0.0003933 1.50 rs11036538 52.9 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 11 0.0003934 1.84 rs6501786 101.4 logistic low glomerular fitration rate vs. control (at entry) 17 0.0003936 1.57 rs10963792 33.2 logistic low creatinine clearance vs. normal creatinine clearance 9 0.0003938 1.43 rs9343494 88.6 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 6 0.0003939 1.53 rs1694594 239.5 logistic AGE, SEX albuminuria vs. no albuminuria (at entry) 1 0.0003939 0.73 rs9359674 92.6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 6 0.0003939 1.96 rs17258731 146.1 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 6 0.0003942 1.57 rs7111704 140.8 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 11 0.0003943 0.50 rs4657486 177.4 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs. control (follow-up) 1 0.0003944 1.29 rs1035898 131.3 logistic AGE, SEX albuminuria vs. no albuminuria (follow-up) 5 0.0003944 1.31 rs970022 145.9 logistic AGE, SEX albuminuria vs. no albuminuria (follow-up) 4 0.0003944 1.28 rs7778081 141.2 logistic microalbuminuria vs. no albuminuria (at entry) 7 0.0003944 1.46 rs6582 38.4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 15 0.0003944 1.34 rs11764407 111.8 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 7 0.0003945 1.28 rs7300192 65.4 logistic GE, AGE, SEX low creatinine clearance vs. normal creatinine clearance 12 0.0003945 0.76

rs2394999 44 9 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 6 00003945 154 rs4470330 82 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 2 00003946 041 rs4277507 82 3 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 2 00003946 041 rs16956216 33 8 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 18 00003949 226 rs6878137 97 3 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 5 0000395 136 rs6877822 97 3 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 5 0000395 136 rs17105368 147 6 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 10 0000395 177 rs7911998 147 6 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 10 0000395 177 rs10859609 96 9 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 00003952 033 rs11752805 166 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 00003952 134 rs11688740 80 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 00003953 152 rs7185053 27 3 logistic microalbuminuria vs no albuminuria (at entry) 16 00003954 069 rs1555157 48 8 logistic GE ₁ AGE, SEX low glomerular fitration rate vs control (follow-up) 20 00003955 059 rs4757711 21 8 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00003955 074 rs432793 147 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00003957 069 rs7841489 125 5 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00003958 057 rs2348914 141 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 7 00003959 158 rs16837766 261 3 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 0000396 069 rs1359437 11 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 00003961 073

Ul rs769267 47 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 19 00003961 138 K> rs12681129 79 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 00003962 129 rs11070279 384 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 15 00003963 148 rs2717637 67 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 8 00003963 081 rs11070279 38 4 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 15 00003964 135 rs7217945 9 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 17 00003964 072 rs10231343 66 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00003967 138 rs2018548 1184 logistic macroalbuminuria vs no albuminuria (at entry) 6 0000397 193 rs2142090 43 7 logistic macroalbuminuria vs no albuminuria (at entry) 21 0000397 150 rs11838024 70 1 logistic microalbuminuria vs no albuminuria (at entry) 12 0000397 132 rs1894898 67 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 16 00003972 135 rs6455209 82 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00003972 068 rs10490114 78 6 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 2 00003974 060 rs574695 60 1 logistic albuminuria vs no albuminuria (at entry) 11 00003975 079 rs6977739 98 1 logistic albuminuria vs no albuminuria (follow-up) 7 00003976 159 rs4586627 226 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 00003976 074 rs6488711 31 3 logistic microalbuminuria vs no albuminuria (at entry) 12 00003979 068 rs10142154 37 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 14 00003979 072 rs12362410 110 9 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00003979 074 rs6831744 145 0 logistic low glomerular fitration rate vs control (at entry) 4 0000398 064 rs10895090 98 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 11 0000398 126

rs4334629 41 8 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00003982 074 rs4775698 44 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 15 00003982 132 rs431966 9 8 logistic low glomerular fitration rate vs control (at entry) 1 00003983 066 rs2013004 48 0 logistic microalbuminuria vs no albuminuria (at entry) 9 00003983 136 rs7124872 111 5 logistic low glomerular fitration rate vs control (follow-up) 11 00003985 155 rs4789188 101 5 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 17 00003985 154 rs2296580 124 7 logistic macroalbuminuria vs no albuminuria (at entry) 10 00003985 061 rs11253562 0 4 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 10 00003987 078 rs1332457 129 2 logistic low glomerular fitration rate vs control (follow-up) 9 00003987 061 rs158688 970 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 9 00003987 074 rs17673703 38 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 15 00003969 070 rs1898445 82 6 logistic AGE ₁ SEX low glomerular fitration rate vs control (at entry) 2 0000399 067 rs375973 137 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 10 0000399 079 rs1932604 74 5 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 10 0000399 068 rs7342195 53 6 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 00003991 152 rs7208976 18 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 17 00003991 068 rs2090018 44 2 logistic microalbuminuria vs no albuminuria (at entry) 17 00003991 071 rs10128526 81 9 logistic low glomerular fitration rate vs control (at entry) 10 00003993 146 rs6477872 103 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 9 00003993 128 rs1536790 25 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00003993 132

K> Ul rs9315454 296 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00003993 150 rs17509991 76 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 00003994 040 rs17080594 50 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00003995 144 rs7910212 16 0 logistic albuminuria vs no albuminuria (at entry) 10 00003996 143 rs6033406 32 5 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 00003998 134 rs2192859 67 3 logistic AGE ₁ SEX low glomerular fitration rate vs control (at entry) 16 00003998 137 rs9519630 89 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00004 061 rs4290350 89 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00004 061 rs2348914 141 1 logistic albuminuria vs no albuminuria (at entry) 7 00004002 142 rs17076442 145 7 logistic low creatinine clearance vs normal creatinine clearance 6 00004002 196 rs12895787 91 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 14 00004003 163 rs737605 113 5 logistic GE ₁ AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 4 00004004 130 rs17271123 56 3 logistic microalbuminuria vs no albuminuria (at entry) 15 00004007 076 rs7315192 59 4 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 00004009 072 rs7693333 110 1 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs control (follow-up) 4 0000401 126 rs17137304 26 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 7 0000401 154 rs4901755 62 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 14 00004011 132 rs6955265 151 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 7 00004011 073 rs17801910 78 0 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (at entry) 12 00004012 186 rs8000282 76 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 13 00004013 155

rs3111694 814 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 4 00004013 133 rs13272473 467 logistic microalbuminuria or macroalbuminuπa vs control (follow-up) 8 00004013 071 rs2144825 132 4 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 14 00004014 142 rs9933518 111 1 logistic albuminuria vs no albuminuria (follow-up) 16 00004014 129 rs4260776 113 6 logistic albuminuria vs no albuminuria (follow-up) 6 00004015 077 rs3801929 120 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 7 0000402 057 rs10853208 40 6 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 18 00004022 123 rs2826686 14 1 logistic microalbuminuria or macroalbuminuπa vs control (follow-up) 21 00004022 139 rs2169089 10 6 logistic low glomerular fitration rate vs control (at entry) 1 00004023 065 rs4279792 246 1 logistic HBP microalbuminuria vs no albuminuria (at entry) 1 00004028 059 rs10875745 63 7 logistic microalbuminuria vs no albuminuria (at entry) 12 0000403 132 rs6547260 101 8 logistic microalbuminuria or macroalbuminuπa vs control (follow-up) 2 00004031 168 rs379060 157 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 00004032 079 rs1765635 125 5 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00004033 080 rs10109797 101 8 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 8 00004033 075 rs6864026 7 5 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 5 00004035 140 rs1494137 124 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 6 00004036 167 rs17680407 43 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 4 00004037 075 rs17796589 63 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuna vs control (follow-up) 14 00004037 156 rs8094453 81 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 18 0000404 136 rs1637931 244 0 logistic albuminuria vs no albuminuria (at entry) 1 00004043 069 rs8004558 86 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 00004043 160 rs9423342 147 5 logistic AGE, SEX microalbuminuria or macroalbuminuna vs control (at entry) 10 00004044 171 rs6553089 204 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00004046 074 rs4814709 404 logistic HBP microalbuminuria vs no albuminuria (at entry) 20 00004047 062 rs298184 81 0 logistic low glomerular fitration rate vs control (at entry) 8 00004048 048 rs7935913 111 5 logistic low glomerular fitration rate vs control (follow-up) 11 00004049 155 rs4146178 56 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00004049 129 rs1694594 239 5 logistic albuminuria vs no albuminuria (at entry) 1 0000405 073 rs1460540 66 9 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 10 00004051 175 rs6041325 32 6 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 00004051 134 rs1452420 38 5 logistic low creatinine clearance vs normal creatinine clearance 2 00004053 138 rs2093852 207 5 logistic GE, AGE, SEX macroalbuminuna vs no albuminuria (at entry) 1 00004054 066 rs7746351 166 6 logistic microalbuminuria or macroalbuminuna vs control (at entry) 6 00004054 134 rs879703 97 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 12 00004055 132 rs3912537 79 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 8 00004056 146 rs4279411 166 6 logistic albuminuria vs no albuminuria (at entry) 6 00004057 079 rs10521324 73 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 16 00004058 121 rs4783894 73 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 16 00004058 121 rs17779263 95 9 logistic microalbuminuria vs no albuminuria (at entry) 17 00004059 178

rs4861686 200 6 logistic microalbuminuria vs no albuminuria (at entry) 4 0000406 132 rs826590 119 6 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 2 00004061 074 rs8121916 32 6 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 20 00004061 134 rs17799275 71 4 logistic AGE, SEX low glomerular titration rate vs control (at entry) 15 00004061 069 rs1028427 75 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 00004061 082 rs1469999 111 2 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 00004061 069 rs1500226 94 1 logistic AGE, SEX low glomerular titration rate vs control (at entry) 5 00004065 132 rs4757710 21 8 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00004067 074 rs17680407 43 3 logistic albuminuria vs no albuminuria (follow-up) 4 00004068 075 rs1697559 81 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 19 0000407 029 rs9875616 69 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00004071 077 rs2352603 82 2 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 00004071 153 rs2283092 129 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 00004071 148 rs1566990 159 3 logistic microalbuminuria vs no albuminuria (at entry) 2 00004072 147 rs1730913 35 2 logistic albuminuria vs no albuminuria (follow-up) 7 00004074 077 rs821931 126 7 logistic microalbuminuria vs no albuminuria (at entry) 10 00004074 056 rs924640 56 1 logistic AGE, SEX low glomerular titration rate vs control (at entry) 4 00004075 203 rs7709237 100 9 logistic low creatinine clearance vs normal creatinine clearance 5 00004076 138 rs6761875 45 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00004077 146

Ul rs1765618 125 5 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00004078 080 K> rs603151 26 3 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 1 0000408 139 rs7672528 92 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 4 0000408 169 rs13095931 173 6 logistic macroalbuminuria vs no albuminuria (at entry) 3 00004081 152 rs2284512 28 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 21 00004081 169 rs4586627 226 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 2 00004081 074 rs4461205 148 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00004083 054 rs17067875 67 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00004083 077 rs9343494 88 6 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 6 00004084 138 rs982926 130 3 logistic albuminuria vs no albuminuria (at entry) 5 00004084 130 rs3737150 26 3 logistic albuminuria vs no albuminuria (follow-up) 9 00004084 132 rs28890483 51 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 15 00004084 154 rs6978780 111 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00004084 136 rs12130167 162 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00004087 129 rs9317560 50 4 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 13 00004088 073 rs11121778 25 1 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00004088 050 rs2114913 108 9 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 00004088 258 rs6136503 41 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 20 0000409 146 rs7253956 56 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 19 0000409 075 rs4514740 44 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 17 00004091 070 rs10894321 137 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00004093 078

rs603397 75 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 00004093 081 rs9314727 65 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 9 00004093 074 rs9877228 117 2 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (at entry) 3 00004094 127 rs3108066 78 5 logistic macroalbuminuπa vs no albuminuria (at entry) 7 00004094 162 rs1351887 105 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 18 00004094 045 rs7977693 96 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00004094 141 rs1470413 269 7 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 2 00004095 074 rs2832648 27 5 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 21 00004096 063 rs2348914 141 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 7 00004097 142 rs12590483 52 0 logistic albuminuria vs no albuminuria (follow-up) 14 00004097 133 rs10245556 72 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00004097 143 rs955051 119 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 11 00004099 148 rs3804775 117 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 000041 131 rs7735132 94 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 5 000041 073 rs4866555 7 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 000041 140 rs41465546 74 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 17 00004101 209 rs 11023705 21 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00004102 079 rs11688740 80 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 2 00004102 137 rs1571317 29 6 logistic macroalbuminuria vs no albuminuria (at entry) 13 00004104 151

Ul rs3856447 19 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00004105 071 rs286216 34 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 19 00004105 127 rs7042894 56 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00004105 135 rs1532554 8 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 00004105 071 rs4901755 62 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 14 00004106 132 rs1872829 53 2 logistic microalbuminuria vs no albuminuria (at entry) 12 00004106 131 rs10196764 202 7 logistic microalbuminuria vs no albuminuria (at entry) 2 00004107 075 rs1334237 41 4 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 13 00004108 134 rs1776046 239 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00004108 069 rs4528272 132 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 10 00004108 151 rs12211633 46 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 0000411 075 rs2654981 112 4 logistic macroalbuminuria vs no albuminuria (at entry) 15 00004111 066 rs1360411 32 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 00004111 134 rs8121916 32 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 20 00004112 145 rs9830266 67 0 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00004113 077 rs222931 22 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 21 00004113 082 rs2826686 14 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 21 00004113 139 rs41521644 191 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00004113 048 rs2251760 86 0 logistic microalbuminuria vs no albuminuria (at entry) 9 00004116 134 rs12346176 0 9 logistic albuminuria vs no albuminuria (at entry) 9 00004117 077 rs2926862 156 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00004118 143

rs2217250 97 3 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 5 00004119 136 rs4716619 180 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00004119 080 rs2911659 126 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00004119 131 rs1947417 82 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 0000412 069 rs979058 17 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00004121 080 rs10889155 88 9 logistic low glomerular titration rate vs control (at entry) 1 00004122 144 rs17021632 146 6 logistic albuminuria vs no albuminuria (follow-up) 4 00004122 034 rs41388648 202 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00004122 073 rs12602903 74 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 17 00004123 128 rs830134 72 2 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 19 00004126 127 rs2481628 191 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 1 00004126 135 rs6980348 128 0 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00004126 121 rs11707973 152 6 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 3 00004129 066 rs406333 29 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 0000413 070 rs10124870 112 4 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00004134 159 rs11848645 37 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 14 00004135 126 rs1397706 163 7 logistic low glomerular fitration rate vs control (follow-up) 2 00004136 219 rs4384747 170 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 2 00004136 140 rs3781349 125 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00004137 128

Ul rs1549840 76 6 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance K> 2 00004137 142 rs2303788 87 7 logistic low glomerular fitration rate vs control (at entry) 16 00004138 149 rs10128270 81 9 logistic low glomerular fitration rate vs control (at entry) 10 00004138 146 rs1896319 124 0 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 12 00004138 143 rs6657063 125 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00004138 084 rs3753305 187 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00004139 078 rs16830489 204 4 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 0000414 214 rs10735253 94 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 00004143 191 rs17594665 76 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00004143 040 rs11152369 76 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00004143 040 rs928579 120 3 logistic low creatinine clearance vs normal creatinine clearance 10 00004144 072 rs10515043 74 0 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 17 00004144 125 rs9908767 44 1 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 17 00004145 069 rs17692715 85 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 6 00004146 066 rs7185053 27 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 16 00004148 071 rs1171556 160 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00004149 064 rs1472095 36 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 4 0000415 134 rs7183000 115 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 15 00004151 145 rs17021632 146 6 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00004151 034 rs13015251 78 4 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00004151 170 rs12002851 99 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 9 00004152 178

rs10843144 195 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00004152 073 rs1218661 262 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00004153 138 rs6857087 133 6 logistic low creatinine clearance vs normal creatinine clearance 4 00004156 139 rs2194391 726 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 2 00004156 168 rs9364250 185 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 00004157 076 rs2034783 106 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00004158 134 rs2447208 40 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 15 00004158 141 rs12966869 94 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 18 00004158 047 rs7133648 10 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00004158 072 rs6552719 192 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 4 00004159 141 rs6590229 128 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 11 00004161 078 rs9461799 45 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 00004161 134 rs4673727 195 7 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00004163 147 rs7985116 86 0 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 13 00004164 073 rs6429453 275 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 1 00004164 198 rs9830266 67 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00004164 077 rs1812582 48 0 logistic albuminuria vs no albuminuria (follow-up) 9 00004167 134 rs4936235 148 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 11 00004167 159 rs10259377 66 3 logistic MBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00004167 138

Ul rs10891169 94 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 11 00004168 069

W

O rs6095323 71 6 logistic low glomerular fitration rate vs control (at entry) 20 00004169 067 rs13285280 72 6 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 9 00004169 061 rs1428419 131 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00004169 130 rs10063876 131 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00004169 130 rs1366355 131 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 5 00004169 130 rs8103089 99 9 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 19 00004169 065 rs10758202 57 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 9 0000417 068 rs4936235 148 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 11 0000417 159 rs11056174 31 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00004171 071 rs11838024 70 1 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00004172 132 rs11152369 76 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 00004172 040 rs17594665 76 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 00004172 040 rs11586374 208 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 1 00004172 159 rs10733459 56 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00004175 134 rs257778 28 2 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00004175 149 rs1548447 37 1 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00004177 169 rs2471512 94 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00004177 063 rs6033406 32 5 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 20 00004178 144 rs6041325 32 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 20 00004178 144 rs1393757 172 3 logistic low glomerular fitration rate vs control (follow-up) 3 00004179 063

rs6756764 134 2 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00004179 128 rs16825798 186 8 logistic low glomerular fitration rate vs control (follow-up) 3 0000418 045 rs16854019 178 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 0000418 145 rs11166629 150 4 logistic low creatinine clearance vs normal creatinine clearance 8 00004181 069 rs16863056 205 9 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00004182 206 rs2292927 159 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 00004183 165 rs11510517 121 1 logistic HBP microalbuminuria vs no albuminuria (at entry) 6 00004184 127 rs942989 43 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 20 00004185 246 rs2113545 142 5 logistic macroalbuminuria vs no albuminuria (at entry) 7 00004186 152 rs1453654 122 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 11 00004187 065 rs341395 54 0 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 15 0000419 215 rs1966909 103 3 logistic macroalbuminuria vs no albuminuria (at entry) 2 0000419 062 rs17600042 108 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 0000419 050 rs2962615 5 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 5 00004192 127 rs9317562 50 4 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 13 00004193 073 rs7691652 114 9 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00004194 064 rs4911536 49 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 20 00004194 137 rs4985702 44 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 17 00004195 071 rs17067875 67 0 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00004195 077

Ul rs7967892 58 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00004197 130 rs17154065 35 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 10 00004198 142 rs2195839 142 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00004198 082 rs3762404 244 2 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00004199 119 rs7119426 66 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00004199 143 rs10973014 0 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 9 00004201 078 rs2926862 156 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 5 00004202 151 rs7191101 104 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00004202 145 rs4276176 90 2 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00004202 066 rs7498488 111 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 16 00004203 129 rs1344361 148 1 logistic macroalbuminuria vs no albuminuria (at entry) 12 00004203 434 rs702605 60 7 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00004205 081 rs1507727 1 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 18 00004208 154 rs2254221 38 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 00004208 075 rs7975956 63 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00004208 128 rs151052 69 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 20 00004208 148 rs4496808 32 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 00004209 125 rs966659 150 4 logistic low creatinine clearance vs normal creatinine clearance 8 00004209 069 rs2710016 38 3 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 0000421 077 rs1240385 107 4 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 10 0000421 277 rs4412353 83 6 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 00004212 063

rs1382394 87.3 logistic AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 18 0.0004212 0.74 rs6882270 49.0 logistic albuminuria vs. no albuminuria (follow-up) 5 0.0004212 0.73 rs7567280 186.0 logistic albuminuria vs. no albuminuria (follow-up) 2 0.0004212 0.79 rs1647965 137.3 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 11 0.0004212 0.73 rs11223077 141.0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 11 0.0004212 0.47 rs6808202 178.5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 3 0.0004213 0.56 rs7185053 27.3 logistic albuminuria vs. no albuminuria (follow-up) 16 0.0004214 0.73 rs931120 131.3 logistic GE, AGE, SEX albuminuria vs. no albuminuria (follow-up) 5 0.0004214 1.37 rs226389 19.3 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 12 0.0004215 1.31 rs7962233 119.1 logistic low glomerular fitration rate vs. control (follow-up) 12 0.0004215 0.57 rs8044632 67.2 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 16 0.0004216 1.33 rs791743 191.8 logistic GE, AGE, SEX albuminuria vs. no albuminuria (at entry) 1 0.0004216 1.35 rs9349997 30.2 logistic low glomerular fitration rate vs. control (at entry) 6 0.0004217 1.54 rs7901744 81.9 logistic low glomerular fitration rate vs. control (at entry) 10 0.0004217 1.46 rs11949897 89.9 logistic GE, AGE, SEX albuminuria vs. no albuminuria (at entry) 5 0.0004217 0.73 rs9976483 30.2 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 21 0.0004219 1.30 rs2090980 84.8 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 11 0.000422 1.41 rs7136397 59.4 logistic low glomerular fitration rate vs. control (follow-up) 12 0.000422 1.50 rs17796864 147.7 logistic albuminuria vs. no albuminuria (at entry) 5 0.000422 1.30

Ul rs6720074 182.6 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 2 0.000422 0.72 rs7190186 80.3 logistic low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 16 0.0004221 1.33 rs17119427 91.9 logistic low creatinine clearance vs. normal creatinine clearance 14 0.0004221 2.59 rs10500411 78.2 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 16 0.0004222 1.70 rs2741311 238.1 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 2 0.0004222 0.45 rs3917786 187.5 logistic GE, AGE, SEX microalbuminuria vs. no albuminuria (at entry) 1 0.0004223 0.76 rs1882257 181.4 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 3 0.0004223 0.81 rs17076531 145.7 logistic low creatinine clearance vs. normal creatinine clearance 6 0.0004226 1.93 rs10460712 33.5 logistic low creatinine clearance vs. normal creatinine clearance 21 0.0004226 1.57 rs344701 28.4 logistic GE, AGE, SEX low creatinine clearance vs. normal creatinine clearance 5 0.0004227 0.75 rs9363771 80.3 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 6 0.0004227 0.73 rs34273034 112.9 logistic GE, AGE, SEX low glomerular fitration rate vs. control (follow-up) 8 0.0004228 0.65 rs6882270 49.0 logistic AGE, SEX albuminuria vs. no albuminuria (follow-up) 5 0.0004228 0.73 rs4936625 117.9 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 11 0.0004228 0.66 rs1351887 105.5 logistic microalbuminuria vs. no albuminuria (at entry) 18 0.000423 0.45 rs702604 60.7 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 5 0.0004231 0.81 rs2284512 28.6 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 21 0.0004231 1.69 rs2828098 17.5 logistic GE, AGE, SEX microalbuminuria vs. no albuminuria (at entry) 21 0.0004232 1.28 rs11707973 152.6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 3 0.0004232 0.68 rs7229063 109.3 logistic low creatinine clearance vs. normal creatinine clearance 18 0.0004234 1.40 rs406333 29.4 logistic GE, AGE, SEX low creatinine clearance vs. normal creatinine clearance 3 0.0004234 0.70

rs2851870 83 9 logistic low glomerular titration rate vs control (at entry) 18 00004237 068 rs7242256 26 6 logistic low glomerular titration rate vs control (follow-up) 18 00004237 068 rs4933346 105 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 10 00004237 078 rs6999595 83 6 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 8 00004238 063 rs17680996 19 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00004238 072 rs2194391 72 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00004239 168 rs17046481 45 0 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 2 0000424 166 rs292071 43 4 logistic low glomerular titration rate vs control (follow-up) 4 0000424 065 rs9315454 29 6 logistic macroalbuminuria vs no albuminuria (at entry) 13 0000424 150 rs17796864 147 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00004241 130 rs7992054 89 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00004242 061 rs3117598 81 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 4 00004242 133 rs7123164 7 3 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 11 00004243 071 rs2087273 25 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00004243 066 rs8086400 105 1 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 18 00004244 069 rs12407055 217 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00004244 071 rs1171556 160 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 1 00004245 064 rs340297 172 3 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 3 00004246 081 rs7592852 202 7 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00004246 078

Ul rs2730306 20 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00004246 192 rs1118433 87 4 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00004247 075 rs4514740 44 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 17 00004247 072 rs11781066 49 7 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 8 00004248 142 rs11219092 120 6 logistic low creatinine clearance vs normal creatinine clearance 11 00004248 265 rs407929 74 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 14 00004248 145 rs11640993 67 3 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 16 00004249 139 rs8089273 94 7 logistic albuminuria vs no albuminuria (at entry) 18 00004249 048 rs3743034 38 7 logistic low creatinine clearance vs normal creatinine clearance 15 00004249 137 rs369651 29 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00004249 078 rs2654981 112 4 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 15 00004249 066 rs2789416 166 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00004251 059 rs12511845 132 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 4 00004251 067 rs11060924 163 7 logistic microalbuminuria vs no albuminuria (at entry) 12 00004252 049 rs11193235 103 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 10 00004253 073 rs10485214 154 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 6 00004253 054 rs4608500 81 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00004255 132 rs16994846 53 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 22 00004256 034 rs11021710 17 7 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 11 00004257 073 rs3776338 145 9 logistic low glomerular titration rate vs control (follow-up) 5 00004258 067 rs6546797 90 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00004259 130

rs11232346 84.3 logistic AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 11 0.000426 0.64 rs17011370 94.5 logistic macroalbuminuria vs. no albuminuria (at entry) 2 0.0004261 1.97 rs931120 131.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 5 0.0004261 1.51 rs3919653 5.1 logistic low creatinine clearance vs. normal creatinine clearance 7 0.0004262 1.37 rs13250299 164.2 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 8 0.0004262 0.74 rs6596989 5.6 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 6 0.0004264 0.78 rs6012271 68.6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 20 0.0004264 1.38 rs4713674 46.5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 6 0.0004264 1.36 rs2023625 102.5 logistic GE, AGE, SEX albuminuria vs. no albuminuria (follow-up) 8 0.0004266 0.54 rs2841941 251.3 logistic AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 1 0.0004267 1.27 rs10495829 53.5 logistic GE, AGE, SEX albuminuria vs. no albuminuria (at entry) 2 0.0004268 2.23 rs620095 107.3 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 11 0.0004269 1.46 rs2833995 30.2 logistic microalbuminuria vs. no albuminuria (at entry) 21 0.0004269 1.30 rs 17796589 63.6 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 14 0.0004269 1.56 rs688808 129.8 logistic AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 4 0.000427 0.68 rs13300278 102.8 logistic AGE, SEX albuminuria vs. no albuminuria (at entry) 9 0.000427 1.30 rs10259269 66.3 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 7 0.000427 1.36 rs7251213 33.6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 19 0.000427 1.33 rs10485214 154.1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 6 0.0004271 0.54 o, rs829573 48.7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 2 0.0004272 0.69 j-J rs17157227 62.3 logistic low glomerular fitration rate vs. control (follow-up) 11 0.0004274 0.56 rs7073811 103.9 logistic albuminuria vs. no albuminuria (at entry) 10 0.0004275 0.77 rs7987244 59.3 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 13 0.0004277 1.43 rs6492734 73.8 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 13 0.0004278 0.73 rs2723483 20.7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 7 0.0004278 1.50 rs4924481 38.4 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 15 0.000428 1.33 rs4658507 273.5 logistic macroalbuminuria vs. no albuminuria (at entry) 1 0.0004281 0.64 rs6916438 155.5 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 6 0.0004282 1.83 rs10894319 137.3 logistic HBP microalbuminuria vs. no albuminuria (at entry) 11 0.0004282 0.73 rs1177257 42.4 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 14 0.0004283 0.71 rs9523993 72.5 logistic GE, AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 13 0.0004283 1.54 rs6506901 57.6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 18 0.0004285 0.75 rs6439200 144.1 logistic albuminuria vs. no albuminuria (at entry) 3 0.0004286 0.64 rs8089273 94.7 logistic AGE, SEX albuminuria vs. no albuminuria (at entry) 18 0.0004286 0.48 rs1416079 113.1 logistic GE, AGE, SEX albuminuria vs. no albuminuria (at entry) 1 0.0004287 1.61 rs9892167 74.1 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 17 0.0004287 1.21 rs2024476 66.6 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 16 0.0004288 0.73 rs2620772 78.0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 12 0.0004288 0.74 rs7592852 202.7 logistic albuminuria vs. no albuminuria (follow-up) 2 0.0004291 0.78 rs17036537 71.3 logistic GE, AGE, SEX microalbuminuria vs. no albuminuria (at entry) 2 0.0004291 0.57

rs2826683 14 1 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 21 00004291 139 rs13015251 78 4 logistic macroalbuminuria vs no albuminuria (at entry) 2 00004292 170 rs6773962 173 6 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00004293 152 rs6866354 59 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00004293 074 rs2841941 251 3 logistic low glomerular Titration rate vs control (at entry) 1 00004294 143 rs6033406 32 5 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 00004295 134 rs2839580 49 8 logistic microalbuminuria vs no albuminuria (at entry) 21 00004295 077 rs11037175 53 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 11 00004295 073 rs9399834 111 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00004295 136 rs 12966869 94 6 logistic albuminuria vs no albuminuria (at entry) 18 00004296 047 rs9572780 53 0 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 13 00004297 054 rs4321205 38 9 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00004299 074 rs4280249 38 9 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00004299 074 rs4369676 38 9 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00004299 074 rs4955205 58 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00004299 152 rs2900601 123 7 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 9 000043 193 rs6808207 67 0 logistic GE ₁ AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 000043 077 rs574695 60 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00004301 079 rs 13095931 173 6 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 3 00004301 152 rs7987244 59 3 logistic microalbuminuria vs no albuminuria (at entry) 13 00004302 135

Ul rs4691961 164 7 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 4 00004303 074 rs7100934 69 8 logistic low glomerular fitration rate vs control (at entry) 10 00004304 142 rs12983573 33 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 19 00004304 073 rs11119552 229 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00004305 131 rs2826683 14 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 21 00004307 139 rs7208976 18 3 logistic AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 17 00004308 068 rs1866479 131 6 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 0000431 068 rs6814897 95 2 logistic AGE ₁ SEX low glomerular fitration rate vs control (at entry) 4 0000431 193 rs2190963 23 2 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (at entry) 17 0000431 214 rs7203172 48 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 16 0000431 063 rs 17267585 72 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00004311 155 rs1569175 195 7 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00004313 154 rs1171556 160 8 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00004313 064 rs3737150 26 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 9 00004315 132 rs4266861 208 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 1 00004317 159 rs622917 46 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 6 00004319 073 rs7087529 148 2 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs control (at entry) 10 0000432 127 rs1366354 131 3 logistic AGE ₁ SEX albuminuria vs no albuminuria (follow-up) 5 0000432 130 rs8012459 93 7 logistic macroalbuminuria vs no albuminuria (at entry) 14 0000432 226 rs2837366 43 7 logistic macroalbuminuria vs no albuminuria (at entry) 21 0000432 055

rs448666 60 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 5 00004325 058 rs6052724 12 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 20 00004325 137 rs13228917 141 2 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 7 00004329 060 rs149473 131 4 logistic macroalbuminuria vs no albuminuria (at entry) 5 0000433 165 rs1453183 38 4 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 15 00004332 147 rs2532660 137 6 logistic albuminuria vs no albuminuria (follow-up) 10 00004332 130 rs6720074 182 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 00004333 072 rs42511 104 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00004334 083 rs8000282 76 3 logistic albuminuria vs no albuminuria (at entry) 13 00004335 150 rs11586374 208 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00004335 137 rs17042290 84 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00004335 072 rs8092690 117 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00004337 042 rs7988550 91 7 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 13 00004338 073 rs2698119 35 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 10 00004338 131 rs2710016 38 3 logistic low glomerular fitration rate vs control (at entry) 2 0000434 069 rs10493578 103 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 0000434 076 rs1776046 239 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00004341 073 rs17042290 84 6 logistic microalbuminuria vs no albuminuria (at entry) 12 00004341 072 rs2731640 94 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00004342 063

Ul rs10000497 43 4 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 00004343 079 rs10800811 204 7 logistic microalbuminuria vs no albuminuria (at entry) 1 00004343 074 rs11940866 127 7 logistic macroalbuminuria vs no albuminuria (at entry) 4 00004346 184 rs2248225 19 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 21 00004346 135 rs3844157 77 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 10 00004347 142 rs17036537 71 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00004348 061 rs1477437 28 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 15 0000435 189 rs9933518 111 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 16 00004351 129 rs6476126 7 0 logistic low glomerular fitration rate vs control (follow-up) 9 00004353 147 rs7111826 46 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 11 00004353 075 rs13390257 215 4 logistic low creatinine clearance vs normal creatinine clearance 2 00004353 136 rs10513360 166 5 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 3 00004355 066 rs8047864 184 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 16 00004356 196 rs2359630 16 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 4 00004356 132 rs11081564 125 0 logistic albuminuria vs no albuminuria (follow-up) 18 00004358 133 rs4712300 33 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00004358 073 rs226387 19 3 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 12 00004359 133 rs17146098 129 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00004359 177 rs11245078 154 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 10 0000436 078 rs4691961 164 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00004361 075 rs11246628 58 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 11 00004362 180

rs2018548 1184 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 6 00004362 193 rs7966105 93 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00004363 074 rs3108049 78 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 00004366 164 rs16854563 212 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 2 00004367 152 rs12303755 94 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00004367 063 rs1224674 45 0 logistic low creatinine clearance vs normal creatinine clearance 15 00004367 068 rs7335946 6 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 13 00004367 141 rs2131887 239 9 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00004369 076 rs10045387 129 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00004369 177 rs11119552 229 7 logistic albuminuria vs no albuminuria (at entry) 1 0000437 131 rs2244672 126 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 0000437 130 rs6479616 96 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 0000437 039 rs7315192 59 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 0000437 072 rs4657486 177 4 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 00004371 131 rs942989 43 1 logistic albuminuria vs no albuminuria (at entry) 20 00004371 246 rs7281608 17 9 logistic microalbuminuria or macroalbuminuria vs control (at entry) 21 00004371 151 rs7592852 202 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00004373 076 rs16853191 178 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 3 00004373 055 rs10851396 38 4 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 15 00004374 134 rs10897992 72 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 11 00004374 059 rs10501407 72 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 11 00004374 059 rs6671984 148 1 logistic albuminuria vs no albuminuria (follow-up) 1 00004375 128 rs1980239 38 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 4 00004375 123 rs869346 91 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 14 00004376 164 rs6597689 151 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00004377 131 rs10982727 123 6 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 9 00004377 163 rs2041909 31 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00004378 072 rs2445859 104 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 19 00004378 172 rs7859675 56 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00004379 132 rs4146178 56 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 9 0000438 130 rs10193792 157 8 logistic low glomerular fitration rate vs control (follow-up) 2 0000438 064 rs3732979 29 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00004382 055 rs8012459 93 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 14 00004383 226 rs1549332 18 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 17 00004383 070 rs32062 159 2 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00004384 128 rs2352603 82 2 logistic macroalbuminuria vs no albuminuria (at entry) 6 00004384 153 rs9872164 90 2 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 3 00004384 068 rs1430382 87 2 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00004385 074 rs7737281 38 2 logistic low glomerular fitration rate vs control (follow-up) 5 00004389 166 rs9642783 112 8 logistic albuminuria vs no albuminuria (follow-up) 8 00004389 284

rs17645681 203 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00004389 068 rs10922207 204 5 logistic low glomerular titration rate vs control (at entry) 1 00004391 288 rs10070447 156 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00004391 077 rs17641512 40 1 logistic microalbuminuria vs no albuminuria (at entry) 13 00004391 066 rs7334517 40 0 logistic microalbuminuria vs no albuminuria (at entry) 13 00004391 066 rs12962651 87 2 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 18 00004392 075 rs17036537 71 3 logistic albuminuria vs no albuminuria (follow-up) 2 00004392 061 rs1539542 27 6 logistic low creatinine clearance vs normal creatinine clearance 13 00004395 069 rs6808207 67 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00004395 077 rs9875616 69 5 logistic albuminuria vs no albuminuria (follow-up) 3 00004396 077 rs11060375 159 6 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 12 00004396 129 rs9940288 5 0 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 16 00004396 184 rs6780822 215 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00004398 128 rs7672620 77 5 logistic low glomerular titration rate vs control (follow-up) 4 00004399 145 rs7696553 77 5 logistic low glomerular titration rate vs control (follow-up) 4 00004399 145 rs2471533 94 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00004399 064 rs3911701 153 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 8 00004399 081 rs13006847 133 5 logistic low creatinine clearance vs normal creatinine clearance 2 000044 136 rs4873713 67 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 8 000044 082 rs16853226 178 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 3 00004401 055 rs6597689 151 3 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 10 00004402 131 rs1452420 38 5 logistic low glomerular titration rate vs control (follow-up) 2 00004402 149 rs461447 72 1 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00004403 066 rs12446492 39 0 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 16 00004405 075 rs2930629 6 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 15 00004405 073 rs1333996 26 3 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 9 00004407 161 rs11940866 127 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 4 00004408 184 rs2699365 131 7 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 2 00004409 068 rs454266 137 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 10 00004409 079 rs8000744 31 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00004409 077 rs7217945 9 2 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 17 0000441 073 rs17156226 110 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 5 0000441 161 rs853956 138 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 10 0000441 129 rs2962394 163 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 5 00004411 070 rs4128841 251 2 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 1 00004414 126 rs317326 55 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 17 00004415 074 rs12120893 127 4 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 1 00004416 155 rs17737516 71 4 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 15 00004417 068 rs1566990 159 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00004417 147 rs17271123 56 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 15 00004418 076

rs17796864 147 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 5 00004423 130 rs6665839 754 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00004424 068 rs12962651 87 2 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00004425 075 rs4420537 38 6 logistic GE ₁ AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00004426 165 rs460976 46 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 21 00004426 226 rs1035898 131 3 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 5 00004427 141 rs1776046 239 5 logistic albuminuria vs no albuminuria (at entry) 1 00004428 073 rs4920708 95 0 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 5 00004428 073 rs6446391 11 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00004431 170 rs11939157 103 8 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00004431 133 rs10858753 94 5 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 12 00004431 160 rs733508 178 9 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00004431 074 rs16953806 71 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 00004431 069 rs4266861 208 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00004432 137 rs4923876 38 4 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 15 00004433 132 rs4796354 13 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 17 00004433 127 rs1382394 87 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 18 00004433 072 rs4233760 39 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 00004433 076 rs448666 60 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 5 00004433 058

Ul rs12549798 84 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 00004434 077 rs9991272 81 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 4 00004434 132 rs7980781 59 4 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 12 00004434 073 rs6472346 83 6 logistic low glomerular fitration rate vs control (follow-up) 8 00004435 054 rs16994846 53 3 logistic albuminuria vs no albuminuria (follow-up) 22 00004435 034 rs1764844 239 1 logistic low glomerular fitration rate vs control (follow-up) 1 00004436 148 rs1912278 106 3 logistic macroalbuminuria vs no albuminuria (at entry) 10 00004437 165 rs357897 69 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 18 00004437 152 rs1218661 262 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00004437 135 rs6736617 72 3 logistic low creatinine clearance vs normal creatinine clearance 2 00004438 141 rs3856447 19 2 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 2 00004439 073 rs7690478 57 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00004441 141 rs16901596 138 2 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 00004442 533 rs17031611 83 7 logistic low glomerular fitration rate vs control (follow-up) 2 00004442 064 rs1963640 29 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00004442 056 rs1047929 4 0 logistic low glomerular fitration rate vs control (at entry) 22 00004446 065 rs2133774 28 6 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 16 00004447 133 rs829584 48 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00004447 069 rs9827713 41 7 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00004449 140 rs4130030 101 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 8 00004449 149 rs6814800 57 2 logistic low glomerular fitration rate vs control (follow-up) 4 0000445 146

rs12211633 46 7 logistic albuminuria vs no albuminuria (follow-up) 6 00004451 075 rs9348953 22 1 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00004451 072 rs401859 71 0 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 5 00004453 134 rs1011275 75 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 2 00004453 076 rs6081676 43 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 20 00004455 256 rs17345528 117 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00004455 134 rs4924304 36 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 15 00004457 173 rs1396678 59 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 13 00004458 133 rs2874710 99 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 3 0000446 128 rs4276176 90 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00004462 067 rs9857723 117 2 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00004463 129 rs622917 46 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 00004464 073 rs6736153 90 1 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00004465 155 rs17186040 27 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 13 00004467 062 rs10193792 157 8 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00004469 066 rs1973150 119 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 14 0000447 131 rs2269436 69 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 00004471 175 rs10459785 27 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 16 00004471 072 rs4490884 0 7 logistic low creatinine clearance vs normal creatinine clearance 8 00004473 061

Ul rs7185053 27 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 16 00004474 073

O rs16953054 74 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 17 00004477 155 rs11193235 103 9 logistic microalbuminuria vs no albuminuria (at entry) 10 00004477 076 rs151052 69 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 20 00004477 148 rs448666 60 8 logistic microalbuminuria vs no albuminuria (at entry) 5 00004478 058 rs4940259 75 2 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 00004478 071 rs982926 130 3 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00004479 130 rs6701181 262 8 logistic low creatinine clearance vs normal creatinine clearance 1 00004481 073 rs1857967 227 3 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00004482 140 rs1530104 131 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00004484 067 rs1380316 151 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00004484 133 rs1477437 28 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 15 00004484 163 rs13271014 88 7 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 8 00004485 159 rs10112627 88 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 8 00004485 159 rs2886927 81 4 logistic microalbuminuria vs no albuminuria (at entry) 4 00004485 131 rs448666 60 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00004485 058 rs1470711 79 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00004486 080 rs1968378 74 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 00004487 129 rs10774823 125 2 logistic albuminuria vs no albuminuria (follow-up) 12 00004488 127 rs1366354 131 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 00004488 141 rs6711891 90 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00004489 130

rs468522 23 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 21 00004489 144 rs4656799 188 6 logistic microalbuminuria or macroalbuminuπa vs control (follow-up) 1 00004489 141 rs644437 116 9 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 10 0000449 138 rs4558955 40 0 logistic GE, AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 5 00004493 068 rs9635573 95 7 logistic low creatinine clearance vs normal creatinine clearance 16 00004494 161 rs1776046 239 5 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 1 00004494 069 rs7073811 103 9 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 10 00004494 073 rs1947414 82 4 logistic albuminuria vs no albuminuria (follow-up) 6 00004498 068 rs7544659 191 7 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00004498 137 rs1515948 45 8 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00004499 144 rs226832 69 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 20 00004499 077 rs1549332 18 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 17 00004499 070 rs617595 59 8 logistic albuminuria vs no albuminuria (at entry) 13 00004502 133 rs9463274 704 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00004503 145 rs2353545 222 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 00004506 139 rs17709552 62 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 11 00004506 055 rs1673887 118 6 logistic macroalbuminuria vs no albuminuria (at entry) 3 00004506 061 rs16825798 186 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 0000451 055 rs16829733 143 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00004512 057 rs4905628 120 0 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 14 00004513 075 rs2396319 226 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00004513 074 rs2839580 49 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 21 00004514 077 rs10884350 126 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 10 00004515 139 rs17025554 113 2 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00004515 068 rs1430377 87 2 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00004516 075 rs10505349 125 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 8 00004516 071 rs468969 23 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 21 00004517 144 rs9592084 48 7 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 13 00004518 128 rs4793378 95 2 logistic low creatinine clearance vs normal creatinine clearance 17 00004519 061 rs17446325 146 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 12 0000452 052 rs28718824 57 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 0000452 060 rs9821016 25 6 logistic macroalbuminuria vs no albuminuria (at entry) 3 00004521 066 rs17643564 73 8 logistic albuminuria vs no albuminuria (follow-up) 10 00004523 076 rs3867493 159 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 00004523 050 rs456016 46 8 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 21 00004524 728 rs2709422 227 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00004524 150 rs10223785 2 2 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 6 00004524 050 rs9287229 262 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 00004525 134 rs7723199 7 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 5 00004525 141 rs6866929 185 8 logistic low creatinine clearance vs normal creatinine clearance 5 00004527 071

rs344701 28 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00004527 075 rs17042290 84 6 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00004528 072 rs9351816 84 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 0000453 126 rs1459375 151 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 10 0000453 132 rs17761559 125 6 logistic low glomerular titration rate vs control (at entry) 10 00004532 166 rs12471083 20 4 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00004533 162 rs731729 134 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00004533 151 rs16889712 124 9 logistic microalbuminuria vs no albuminuria (at entry) 8 00004533 147 rs9908305 90 7 logistic low glomerular titration rate vs control (follow-up) 17 00004534 067 rs4608500 81 6 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00004535 132 rs7248486 52 8 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 19 00004535 150 rs17339036 127 5 logistic HBP microalbuminuria vs no albuminuria (at entry) 10 00004536 139 rs4771651 103 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 13 00004537 133 rs10812364 47 2 logistic low glomerular titration rate vs control (at entry) 9 00004538 069 rs11138007 79 1 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 9 00004539 060 rs12511845 132 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00004539 067 rs2090018 44 2 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 17 0000454 071 rs7047479 61 3 logistic albuminuria vs no albuminuria (follow-up) 9 00004543 127 rs12751725 354 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 1 00004544 072 rs629222 239 1 logistic low glomerular titration rate vs control (at entry) 1 00004545 147

K> rs4535211 41 8 logistic low creatinine clearance vs normal creatinine clearance 3 00004545 135 rs748165 90 9 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 10 00004546 151 rs11070285 38 5 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 15 00004547 146 rs10781686 18 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 00004547 073 rs2502845 191 8 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00004548 137 rs4497678 110 5 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 16 0000455 146 rs245578 137 4 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 00004551 081 rs3917786 187 5 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 00004551 075 rs1711001 205 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00004553 125 rs17168478 141 1 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00004554 152 rs4726563 152 3 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00004556 129 rs42814 60 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00004558 077 rs7119426 66 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 11 00004559 139 rs2709422 227 7 logistic macroalbuminuria vs no albuminuria (at entry) 2 0000456 150 rs4146404 18 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 13 0000456 073 rs1331484 0 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00004561 135 rs41503549 65 2 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 16 00004561 062 rs12312326 125 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00004563 124 rs10858753 94 5 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 12 00004566 158 rs6439200 144 1 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 3 00004566 064

rs1603530 75.1 logistic AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 1 0.0004567 0.71 rs6711054 123.6 logistic GE, AGE, SEX low creatinine clearance vs. normal creatinine clearance 2 0.000457 0.61 rs11168421 63.7 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 12 0.000457 1.30 rs1867876 21.8 logistic low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 11 0.0004571 1.35 rs729438 133.6 logistic GE, AGE, SEX low glomerular fitration rate vs. control (follow-up) 14 0.0004571 1.35 rs17502345 148.0 logistic GE, AGE, SEX albuminuria vs. no albuminuria (at entry) 5 0.0004571 1.29 rs28891 130.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 5 0.0004572 1.56 rs6864026 7.5 logistic microalbuminuria or macroalbuminuria vs. control (follow-up) 5 0.0004572 1.40 rs7680113 205.0 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 4 0.0004573 1.25 rs17737569 71.4 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 15 0.0004573 0.70 rs1428419 131.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 5 0.0004576 1.40 rs10063876 131.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 5 0.0004576 1.40 rs1035897 131.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 5 0.0004576 1.40 rs1366355 131.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 5 0.0004576 1.40 rs9891294 74.0 logistic macroalbuminuria vs. no albuminuria (at entry) 17 0.0004577 1.54 rs1523890 4.8 logistic low glomerular fitration rate vs. control (follow-up) 3 0.000458 1.49 rs4244347 124.4 logistic albuminuria vs. no albuminuria (follow-up) 10 0.0004581 1.29 rs2736172 44.9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 6 0.0004581 1.34 rs6831793 198.5 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 4 0.0004582 1.48

Ul rs4572098 93.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry)

4- 11 0.0004583 0.65 rs11886398 61.4 logistic GE, AGE, SEX low glomerular fitration rate vs. control (follow-up) 2 0.0004585 1.42 rs1472095 36.5 logistic AGE, SEX albuminuria vs. no albuminuria (at entry) 4 0.0004585 1.31 rs12492701 170.4 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 3 0.0004586 0.74 rs4716619 180.5 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 7 0.0004588 0.80 rs11119552 229.7 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 1 0.0004589 1.34 rs10016434 53.7 logistic HBP microalbuminuria vs. no albuminuria (at entry) 4 0.0004589 2.01 rs7811306 97.3 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 7 0.0004591 0.73 rs7094917 7.7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 10 0.0004591 1.34 rs12655096 59.4 logistic GE ₁ AGE ₁ SEX low creatinine clearance vs. normal creatinine clearance 5 0.0004592 0.70 rs184977 137.4 logistic HBP ₁ diabetes duration microalbuminuria vs. no albuminuria (at entry) 5 0.0004592 0.81 rs7485517 35.9 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 12 0.0004593 1.38 rs1551391 102.1 logistic GE, AGE, SEX low creatinine clearance vs. normal creatinine clearance 1 0.0004593 0.83 rs1765635 125.5 logistic AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 1 0.0004594 0.78 rs10792617 84.9 logistic low glomerular fitration rate vs. control (at entry) 11 0.0004594 1.53 rs1333996 26.3 logistic low glomerular fitration rate vs. control (at entry) 9 0.0004597 1.48 rs13413437 119.5 logistic low glomerular fitration rate vs. control (follow-up) 2 0.0004598 1.45 rs9922883 88.3 logistic GE, AGE, SEX low creatinine clearance vs. normal creatinine clearance 16 0.0004601 2.67 rs34319350 87.6 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 4 0.0004602 1.84 rs281302 44.9 logistic low glomerular fitration rate vs. control (follow-up) 15 0.0004603 1.45 rs4905631 120.1 logistic low creatinine clearance vs. normal creatinine clearance 14 0.0004603 0.73

rs2090980 84 8 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 11 00004604 145 rs1114418 137 3 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 11 00004604 074 rs4861686 200 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 4 00004605 132 rs16825798 186 8 logistic microalbuminuria or macroalbuminuπa vs control (at entry) 3 00004607 055 rs11848645 37 9 logistic albuminuria vs no albuminuria (follow-up) 14 00004609 126 rs8099832 87 2 logistic GE, AGE, SEX low glomerular Titration rate vs normal glom filtration rate (follow-up) 18 0000461 074 rs4128658 63 5 logistic albuminuria vs no albuminuria (follow-up) 17 0000461 074 rs408510 71 8 logistic GE ₁ AGE ₁ SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 8 00004611 068 rs17594526 76 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 18 00004611 041 rs7207189 74 1 logistic HBP microalbuminuria vs no albuminuria (at entry) 17 00004612 125 rs10495444 262 1 logistic microalbuminuria or macroalbuminuria vs control (at entry) 1 00004613 134 rs9515093 102 5 logistic AGE, SEX low glomerular titration rate vs control (at entry) 13 00004615 068 rs1003980 33 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 00004617 144 rs12052673 33 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 2 00004617 144 rs1400512 79 6 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 8 00004617 158 rs6095314 71 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 20 00004617 074 rs2169170 114 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 18 00004618 069 rs536730 27 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 22 00004619 182 rs4814709 404 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 20 00004619 062

Ul rs11735854 43 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 4 00004619 073

4- rs10800462 187 5 logistic low glomerular fitration rate vs control (at entry) 1 0000462 143 rs16902186 59 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 5 0000462 073 rs6429453 275 7 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00004621 145 rs7307697 59 0 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 12 00004622 127 rs704829 191 8 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 1 00004622 135 rs17345528 117 4 logistic albuminuria vs no albuminuria (at entry) 3 00004624 131 rs6477872 103 3 logistic albuminuria vs no albuminuria (at entry) 9 00004624 128 rs8054976 121 6 logistic low creatinine clearance vs normal creatinine clearance 16 00004624 059 rs821931 126 7 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 10 00004625 056 rs6102795 57 8 logistic low glomerular fitration rate vs control (follow-up) 20 00004626 065 rs538343 98 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00004626 067 rs13006847 133 5 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00004628 133 rs7764326 164 5 logistic microalbuminuria vs no albuminuria (at entry) 6 00004629 139 rs452616 71 0 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00004631 133 rs996091 80 3 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00004631 073 rs4726116 163 9 logistic low glomerular fitration rate vs control (at entry) 7 00004631 067 rs4976983 164 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 8 00004635 074 rs9458689 170 9 logistic low glomerular fitration rate vs control (at entry) 6 00004636 210 rs6909531 170 9 logistic low glomerular fitration rate vs control (at entry) 6 00004636 210 rs6560309 67 9 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00004637 124

rs8105738 103 3 logistic GE, AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 19 00004637 147 rs2053158 101 5 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 17 00004638 141 rs1062492 3 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 00004638 054 rs16863056 205 9 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00004639 206 rs926082 43 7 logistic macroalbuminuria vs no albuminuria (at entry) 21 0000464 149 rs1961016 43 4 logistic albuminuria vs no albuminuria (follow-up) 4 00004641 079 rs11848645 37 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 14 00004641 138 rs12489725 170 4 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 3 00004642 074 rs1477437 28 5 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 15 00004643 189 rs11036538 52 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 11 00004644 184 rs3008621 241 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 1 00004644 134 rs2110379 117 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00004644 126 rs6673069 75 1 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 1 00004645 072 rs7837959 128 6 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (at entry) 8 00004645 080 rs2895598 37 0 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 10 00004645 071 rs1404868 93 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00004646 073 rs4548801 128 6 logistic low creatinine clearance vs normal creatinine clearance 14 00004648 139 rs2699367 131 7 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 2 00004649 067 rs7988514 6 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00004649 076

'Jl rs1010900 145 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 3 0000465 134

Ul rs2225361 125 8 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 9 00004651 123 rs13180 74 2 logistic albuminuria vs no albuminuria (follow-up) 15 00004651 128 rs7765427 91 2 logistic microalbuminuria vs no albuminuria (at entry) 6 00004651 135 rs7493192 114 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 00004651 070 rs7233192 87 3 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 18 00004652 075 rs2057028 60 4 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 20 00004652 154 rs664093 116 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 10 00004652 138 rs9457730 164 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 6 00004655 138 rs4720530 8 6 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 7 00004656 074 rs9920163 39 9 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 15 00004658 143 rs2242722 34 2 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 21 00004658 195 rs11674444 240 6 logistic HBP microalbuminuria vs no albuminuria (at entry) 2 00004658 079 rs7203756 104 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00004658 135 rs17767491 104 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 16 00004658 135 rs16854019 178 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 3 00004658 145 rs558930 58 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00004659 059 rs6701181 262 8 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 1 0000466 072 rs7342195 53 6 logistic macroalbuminuria vs no albuminuria (at entry) 11 0000466 152 rs1878868 72 3 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 12 00004662 062 rs4866555 7 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 5 00004662 140

rs2445859 104.1 logistic AGE, SEX low glomerular titration rate vs. control (follow-up) 19 0.0004663 1.88 rs9788209 90.3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 12 0.0004664 0.62 rs7047479 61.3 logistic AGE, SEX albuminuria vs. no albuminuria (follow-up) 9 0.0004665 1.27 rs18582 117.8 logistic AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 1 0.0004665 0.65 rs6124066 99.8 logistic macroalbuminuria vs. no albuminuria (at entry) 20 0.0004666 0.57 rs11232346 84.3 logistic macroalbuminuria vs. no albuminuria (at entry) 11 0.0004666 0.64 rs2858638 61.6 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 22 0.0004666 0.67 rs1507216 93.7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (at entry) 12 0.0004666 0.74 rs7988254 73.8 logistic GE, AGE, SEX low glomerular fitration rate vs. control (follow-up) 13 0.0004668 1.44 rs10196764 202.7 logistic HBP, diabetes duration microalbuminuria vs. no albuminuria (at entry) 2 0.0004669 0.75 rs217537 117.3 logistic GE, AGE, SEX albuminuria vs. no albuminuria (at entry) 6 0.000467 0.80 rs7228465 26.6 logistic GE, AGE, SEX microalbuminuria vs. no albuminuria (at entry) 18 0.000467 1.28 rs4522813 145.8 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 3 0.0004672 1.34 rs4738836 79.2 logistic GE, AGE, SEX albuminuria vs. no albuminuria (at entry) 8 0.0004675 0.81 rs1241929 91.6 logistic GE ₁ AGE ₁ SEX microalbuminuria vs. no albuminuria (at entry) 14 0.0004675 1.54 rs7317112 74.4 logistic GE ₁ AGE, SEX microalbuminuria vs. no albuminuria (at entry) 13 0.0004675 0.74 rs11156316 111.4 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 6 0.0004676 0.76 rs6597708 151.8 logistic GE, AGE, SEX albuminuria vs. no albuminuria (at entry) 10 0.0004677 1.25 rs7342195 53.6 logistic AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 11 0.000468 1.52

Ul rs6537549 69.7 logistic AGE, SEX low glomerular fitration rate vs. control (at entry)

4- 10 0.0004681 1.44 rs16887282 124.3 logistic macroalbuminuria vs. no albuminuria (at entry) 8 0.0004681 3.61 rs7987244 59.3 logistic AGE, SEX microalbuminuria vs. no albuminuria (at entry) 13 0.0004682 1.35 rs7752425 71.0 logistic AGE, SEX low glomerular fitration rate vs. control (follow-up) 6 0.0004683 1.42 rs2654981 112.4 logistic AGE, SEX macroalbuminuria vs. no albuminuria (at entry) 15 0.0004683 0.66 rs17799275 71.4 logistic GE, AGE, SEX low glomerular fitration rate vs. control (at entry) 15 0.0004684 0.69 rs424301 21.0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 9 0.0004684 1.35 rs597530 122.6 logistic low glomerular fitration rate vs. control (at entry) 11 0.0004685 0.61 rs1472095 36.5 logistic albuminuria vs. no albuminuria (at entry) 4 0.0004685 1.31 rs12956604 109.3 logistic low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 18 0.0004686 1.34 rs369651 29.4 logistic AGE, SEX low creatinine clearance vs. normal creatinine clearance 3 0.0004686 0.78 rs6570848 147.0 logistic AGE, SEX low glomerular fitration rate vs. control (at entry) 6 0.0004687 1.30 rs706679 73.1 logistic low glomerular fitration rate vs. control (at entry) 5 0.0004689 1.69 rs251300 73.1 logistic low glomerular fitration rate vs. control (at entry) 5 0.0004689 1.69 rs998321 57.2 logistic HBP ₁ diabetes duration microalbuminuria vs. no albuminuria (at entry) 2 0.0004689 0.64 rs1470413 269.7 logistic GE, AGE, SEX low glomerular fitration rate vs. normal glom. filtration rate (follow-up) 2 0.000469 0.74 rs8044632 67.2 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs. control (follow-up) 16 0.000469 1.33 rs12407055 217.2 logistic microalbuminuria or macroalbuminuria vs. control (at entry) 1 0.000469 0.71 rs130250 31.1 logistic GE ₁ AGE, SEX microalbuminuria or macroalbuminuria vs. control (follow-up) 22 0.0004691 0.70 rs4789193 101.5 logistic low glomerular fitration rate vs. control (at entry) 17 0.0004692 1.55 rs11783436 37.0 logistic AGE, SEX albuminuria vs. no albuminuria (follow-up) 8 0.0004692 1.29

rs2142090 43 7 logistic AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 21 00004693 150 rs7735132 94 9 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 5 00004693 073 rs4341081 151 1 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 00004693 071 rs7819717 98 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 8 00004695 075 rs1550539 72 8 logistic low glomerular fitration rate vs control (follow-up) 11 00004696 154 rs7307697 59 0 logistic albuminuria vs no albuminuria (at entry) 12 00004696 127 rs10152371 38 7 logistic low glomerular fitration rate vs control (at entry) 15 00004698 146 rs7764326 164 5 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00004699 139 rs4814709 404 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 20 00004701 062 rs4635202 21 3 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 13 00004703 133 rs9821016 25 6 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 3 00004703 066 rs2241152 55 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 00004703 171 rs2677810 251 3 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00004704 126 rs3789052 218 3 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00004705 131 rs6052724 12 4 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 20 00004707 156 rs7632287 28 9 logistic albuminuria vs no albuminuria (at entry) 3 00004708 076 rs28890483 51 5 logistic albuminuria vs no albuminuria (follow-up) 15 00004708 154 rs10275303 138 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00004708 153 rs11888061 83 7 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 2 0000471 063

Ul rs1065786 66 8 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00004712 082

4- rs2359630 16 9 logistic microalbuminuria vs no albuminuria (at entry) 4 00004712 132 rs9402666 136 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00004712 190 rs10511350 130 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 3 00004713 144 rs17674649 42 7 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 2 00004713 064 rs1000927 28 3 logistic low creatinine clearance vs normal creatinine clearance 21 00004714 149 rs9976483 30 2 logistic microalbuminuria vs no albuminuria (at entry) 21 00004714 130 rs11123021 131 6 logistic low creatinine clearance vs normal creatinine clearance 2 00004715 072 rs9391062 111 4 logistic microalbuminuria vs no albuminuria (at entry) 6 00004715 076 rs3909788 125 5 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 12 00004716 065 rs6481864 62 1 logistic microalbuminuria vs no albuminuria (at entry) 10 00004717 175 rs7498488 111 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 16 0000472 141 rs10817737 103 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 9 00004721 074 rs10513527 172 2 logistic macroalbuminuria vs no albuminuria (at entry) 3 00004721 168 rs11169761 65 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 12 00004721 122 rs7818331 150 4 logistic low creatinine clearance vs normal creatinine clearance 8 00004722 070 rs130250 31 1 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 22 00004722 070 rs1612517 80 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 6 00004726 124 rs42814 60 9 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 2 00004726 077 rs2031654 51 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 00004727 067 rs7920751 142 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00004728 062

rs1553953 49 7 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 0000473 063 rs34247980 176 3 logistic AGE, SEX macroalbuminuπa vs no albuminuria (at entry) 6 00004731 198 rs 17025554 113 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 2 00004731 066 rs10198583 126 7 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 2 00004732 174 rs17643564 73 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 10 00004735 076 rs7977693 96 0 logistic microalbuminuria vs no albuminuria (at entry) 12 00004735 141 rs708209 52 0 logistic microalbuminuria vs no albuminuria (at entry) 12 00004737 077 rs16889748 124 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 00004737 162 rs7146217 74 3 logistic albuminuria vs no albuminuria (follow-up) 14 00004738 127 rs150409 21 1 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 9 0000474 078 rs1541749 8 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 00004741 069 rs9521996 106 0 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00004743 130 rs7175582 39 9 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 15 00004744 135 rs1396678 59 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 13 00004744 133 rs3808122 129 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 7 00004744 147 rs225549 146 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 00004745 072 rs7752425 71 0 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 6 00004747 142 rs6715897 232 3 logistic low creatinine clearance vs normal creatinine clearance 2 00004748 061 rs226383 19 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 12 00004748 122 rs4741833 0 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 9 00004748 079 rs719213 123 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 8 00004749 058 rs9875616 69 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00004751 077 rs220673 70 4 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 6 00004751 144 rs4394376 83 6 logistic low glomerular fitration rate vs control (at entry) 8 00004752 061 rs6472334 83 6 logistic low glomerular fitration rate vs control (at entry) 8 00004752 061 rs12609410 103 1 logistic macroalbuminuria vs no albuminuria (at entry) 19 00004752 151 rs11726931 1400 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 00004753 074 rs1729975 114 5 logistic low creatinine clearance vs normal creatinine clearance 3 00004753 153 rs2239578 17 5 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 14 00004753 126 rs9853784 122 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 3 00004753 129 rs1464611 128 6 logistic albuminuria vs no albuminuria (at entry) 8 00004754 127 rs2647442 239 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00004754 131 rs10746342 93 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 00004754 069 rs10259377 66 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00004755 138 rs6701181 262 8 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00004756 072 rs6128872 98 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 20 00004757 089 rs11045415 16 5 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 12 00004757 060 rs16860935 201 2 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00004758 133 rs7295430 94 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 12 00004758 061 rs9924993 27 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 16 00004758 072

rs1765618 125 5 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 0000476 078 rs9877228 117 2 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 3 00004761 129 rs7544659 191 7 logistic low creatinine clearance vs normal creatinine clearance 1 00004763 137 rs2354324 68 0 logistic low creatinine clearance vs normal creatinine clearance 14 00004765 140 rs7335946 6 7 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (at entry) 13 00004766 141 rs360973 67 1 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 8 0000477 082 rs2617191 52 0 logistic microalbuminuria vs no albuminuria (at entry) 12 0000477 074 rs2350786 142 6 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 7 00004771 130 rs17272796 41 8 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 3 00004772 134 rs7632287 28 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 3 00004772 076 rs13240269 66 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 7 00004772 132 rs1979096 27 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00004772 068 rs497898 110 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 11 00004772 144 rs17528058 90 8 logistic albuminuria vs no albuminuria (follow-up) 10 00004773 130 rs1548447 37 1 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00004774 169 rs7073811 103 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 10 00004774 077 rs1897169 116 5 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 2 00004775 133 rs8086400 105 1 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 18 00004779 069 rs4720530 8 6 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 7 00004779 074

Ul rs318860 66 7 logistic low glomerular fitration rate vs control (follow-up) 8 00004782 063 rs841613 48 0 logistic low glomerular fitration rate vs control (at entry) 12 00004783 059 rs10746342 93 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00004784 071 rs221182 46 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 7 00004785 125 rs2185938 28 6 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 9 00004786 140 rs7101928 27 7 logistic macroalbuminuria vs no albuminuria (at entry) 11 00004786 150 rs17099248 67 6 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 14 00004786 141 rs10197623 198 5 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 2 00004788 137 rs4118375 210 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00004788 071 rs1169750 52 7 logistic low creatinine clearance vs normal creatinine clearance 9 00004789 142 rs10116752 102 8 logistic HBP microalbuminuria vs no albuminuria (at entry) 9 0000479 128 rs4572098 93 3 logistic microalbuminuria or macroalbuminuria vs control (at entry) 11 0000479 065 rs12490544 30 3 logistic low glomerular fitration rate vs control (at entry) 3 00004792 183 rs2698119 354 logistic albuminuria vs no albuminuria (at entry) 10 00004792 131 rs2251760 86 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 9 00004793 134 rs10865331 81 5 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00004794 159 rs2367291 81 4 logistic microalbuminuria vs no albuminuria (at entry) 4 00004794 131 rs9305856 8 7 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 21 00004795 166 rs10953106 106 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 7 00004795 079 rs2553954 123 2 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 3 00004796 142 rs340260 172 3 logistic AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 3 00004796 081

rs407929 74 2 logistic microalbuminuria or macroalbuminuria vs control (at entry) 14 00004796 145 rs6052724 12 4 logistic albuminuria vs no albuminuria (at entry) 20 00004797 134 rs4789492 105 5 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 17 00004798 144 rs12960965 81 7 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 18 00004799 147 rs299900 68 7 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 5 00004799 077 rs648638 116 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 10 00004801 138 rs226408 19 3 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 12 00004803 132 rs13250299 164 2 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 8 00004803 074 rs1548445 37 1 logistic GE, AGE, SEX low glomerular titration rate vs control (at entry) 16 00004804 157 rs4584771 96 9 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 15 00004804 077 rs17157227 62 3 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 11 00004805 065 rs1047799 44 3 logistic albuminuria vs no albuminuria (follow-up) 17 00004805 078 rs166412 119 0 logistic low glomerular titration rate vs control (at entry) 1 00004807 058 rs11010400 46 4 logistic albuminuria vs no albuminuria (at entry) 10 00004807 204 rs12603115 64 0 logistic albuminuria vs no albuminuria (at entry) 17 00004807 128 rs6659552 3 4 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 1 00004807 131 rs260005 95 5 logistic GE, AGE, SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 20 00004808 228 rs2046535 198 3 logistic low creatinine clearance vs normal creatinine clearance 4 00004808 135 rs2740485 110 6 logistic microalbuminuria or macroalbuminuria vs control (at entry) 9 00004809 160

Ul rs17631610 165 6 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 4 0000481 155 Ul

O rs10077522 129 9 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 5 0000481 140 rs10493578 103 6 logistic microalbuminuria vs no albuminuria (at entry) 1 00004813 076 rs11025959 27 5 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 11 00004814 074 rs7857417 30 3 logistic GE ₁ AGE, SEX microalbuminuria vs no albuminuria (at entry) 9 00004814 076 rs17673703 38 4 logistic low glomerular titration rate vs control (at entry) 15 00004815 070 rs4076277 170 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 7 00004815 472 rs10280940 170 8 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 7 00004815 472 rs6501786 101 4 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 17 00004817 141 rs7197544 104 7 logistic albuminuria vs no albuminuria (follow-up) 16 00004818 142 rs4756093 41 0 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 11 00004819 149 rs17067875 67 0 logistic microalbuminuria vs no albuminuria (at entry) 3 00004819 077 rs2895598 37 0 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 10 00004819 071 rs4239307 41 8 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 18 00004822 140 rs10892549 116 2 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 11 00004823 068 rs7672441 120 6 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 4 00004825 136 rs10259269 66 3 logistic HBP microalbuminuria vs no albuminuria (at entry) 7 00004825 136 rs6052724 12 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 20 00004826 134 rs16889712 124 9 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 8 00004826 147 rs16880395 43 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00004827 076 rs11886398 61 4 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 2 00004828 142

rs17528058 90 8 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 10 0000483 130 rs11648875 104 7 logistic microalbuminuria or macroalbuminuria vs control (at entry) 16 0000483 156 rs7120706 111 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 00004831 128 rs9908767 44 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 17 00004832 073 rs9830266 67 0 logistic microalbuminuria vs no albuminuria (at entry) 3 00004833 077 rs10743138 15 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00004837 053 rs1359437 11 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 00004837 073 rs11027540 30 1 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 11 00004838 151 rs7985116 86 0 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 13 00004838 073 rs10892549 116 2 logistic low glomerular fitration rate vs control (at entry) 11 00004839 069 rs2334063 4 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 0000484 076 rs1364359 80 3 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00004843 134 rs708209 52 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00004843 077 rs2617191 52 0 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 12 00004844 074 rs10455038 130 3 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00004844 134 rs1966908 103 3 logistic macroalbuminuria vs no albuminuria (at entry) 2 00004845 062 rs221188 46 2 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 7 00004846 129 rs10248275 5 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 7 00004847 184 rs4132236 82 3 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00004849 076 rs7492012 27 7 logistic GE, AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 13 0000485 137 rs7464175 77 9 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 8 0000485 058 rs11060924 163 7 logistic AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 12 00004851 049 rs996091 80 3 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00004852 073 rs8061723 109 8 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs control (follow-up) 16 00004853 175 rs1898445 82 6 logistic GE ₁ AGE, SEX low glomerular fitration rate vs control (at entry) 2 00004854 067 rs6839406 146 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00004854 040 rs4424038 156 7 logistic HBP microalbuminuria vs no albuminuria (at entry) 5 00004854 138 rs3821374 634 logistic low glomerular fitration rate vs control (at entry) 3 00004855 155 rs4778099 94 7 logistic GE ₁ AGE, SEX low creatinine clearance vs normal creatinine clearance 15 00004856 083 rs1588213 56 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00004856 134 rs1551391 102 1 logistic AGE ₁ SEX low creatinine clearance vs normal creatinine clearance 1 00004857 083 rs2474339 172 0 logistic GE ₁ AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 10 00004858 133 rs2465791 73 3 logistic low creatinine clearance vs normal creatinine clearance 7 00004859 071 rs7962233 119 1 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs control (follow-up) 12 00004862 057 rs11677065 87 0 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 2 00004863 126 rs28490018 114 7 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 14 00004863 062 rs586124 34 8 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00004864 129 rs4235846 98 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 6 00004866 169 rs6743009 45 0 logistic GE ₁ AGE ₁ SEX low glomerular fitration rate vs control (at entry) 2 00004868 239 rs4441646 70 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 3 00004868 131

rs781758 124 4 logistic macroalbuminuria vs no albuminuria (at entry) 6 00004868 160 rs10489525 148 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 1 00004874 076 rs10992063 99 4 logistic low glomerular titration rate vs control (at entry) 9 00004877 069 rs7203172 48 8 logistic low glomerular fitration rate vs control (follow-up) 16 00004877 056 rs1422954 163 1 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00004877 071 rs2419533 131 2 logistic GE ₁ AGE, SEX low creatinine clearance vs normal creatinine clearance 4 00004878 141 rs10804520 130 6 logistic AGE, SEX low glomerular titration rate vs control (at entry) 3 0000488 144 rs910771 55 2 logistic HBP microalbuminuria vs no albuminuria (at entry) 22 00004881 080 rs10843144 19 5 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 12 00004881 073 rs1491757 96 8 logistic AGE, SEX low glomerular Titration rate vs control (follow-up) 3 00004882 062 rs10248305 664 logistic GE ₁ AGE, SEX microalbuminuria vs no albuminuria (at entry) 7 00004884 138 rs4955205 58 7 logistic macroalbuminuria vs no albuminuria (at entry) 3 00004885 152 rs11744184 40 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 5 00004885 068 rs18582 117 8 logistic GE ₁ AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 1 00004885 065 rs3845948 61 9 logistic microalbuminuria vs no albuminuria (at entry) 3 00004885 136 rs1077514 52 4 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 1 00004886 067 rs12138732 33 9 logistic HBP microalbuminuria vs no albuminuria (at entry) 1 00004887 061 rs11957907 148 0 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (at entry) 5 00004888 129 rs11070279 38 4 logistic low glomerular titration rate vs control (follow-up) 15 00004889 148

Ul rs7111704 140 8 logistic GE ₁ AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00004889 050 Ul K> rs185793 44 9 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 15 0000489 134 rs6553089 204 9 logistic AGE, SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 4 0000489 080 rs488615 116 1 logistic AGE ₁ SEX macroalbuminuria vs no albuminuria (at entry) 11 0000489 282 rs1514417 17 9 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (at entry) 21 0000489 154 rs1971990 8 1 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00004891 076 rs4146404 18 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 13 00004892 073 rs2116682 167 5 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 3 00004892 076 rs9901549 35 7 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 17 00004893 072 rs13180 74 2 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 15 00004894 128 rs2194390 72 6 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (follow-up) 2 00004895 167 rs1544398 61 4 logistic low creatinine clearance vs normal creatinine clearance 11 00004897 065 rs2991304 7 6 logistic AGE, SEX low glomerular titration rate vs control (follow-up) 9 00004899 142 rs1507727 1 5 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 18 00004899 135 rs1326837 116 7 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 10 00004899 075 rs11884584 36 2 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 2 00004901 144 rs11123021 131 6 logistic GE ₁ AGE, SEX low glomerular titration rate vs control (follow-up) 2 00004903 071 rs2317703 117 3 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (at entry) 3 00004904 126 rs2317750 117 2 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (at entry) 3 00004904 126 rs3846087 117 3 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (at entry) 3 00004904 126 rs1520653 117 2 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (at entry) 3 00004904 126

rs5009801 117 2 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 00004904 126 rs244885 118 1 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 16 00004905 171 rs7621243 42 1 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 3 00004906 067 rs2087273 25 7 logistic macroalbuminuria vs no albuminuria (at entry) 3 00004906 066 rs8082727 106 5 logistic low glomerular titration rate vs control (follow-up) 18 00004907 150 rs12134140 129 8 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 1 00004907 069 rs3008720 29 4 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 9 00004907 152 rs11118204 239 1 logistic low creatinine clearance vs normal creatinine clearance 1 00004907 141 rs1464611 128 6 logistic AGE ₁ SEX albuminuria vs no albuminuria (at entry) 8 00004909 127 rs1445675 155 3 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 5 00004911 132 rs7988254 73 8 logistic AGE, SEX low glomerular titration rate vs control (at entry) 13 00004912 146 rs7301998 594 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 12 00004912 149 rs4128841 251 2 logistic AGE ₁ SEX low glomerular titration rate vs normal glom filtration rate (follow-up) 1 00004913 126 rs13121032 145 9 logistic albuminuria vs no albuminuria (follow-up) 4 00004913 128 rs4362550 218 4 logistic AGE, SEX low glomerular titration rate vs control (at entry) 2 00004916 086 rs1766145 43 0 logistic low glomerular fitration rate vs control (follow-up) 14 00004916 067 rs10773317 147 8 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00004917 066 rs2468255 94 4 logistic albuminuria vs no albuminuria (follow-up) 12 00004918 065 rs7498488 111 7 logistic albuminuria vs no albuminuria (follow-up) 16 00004918 129

Ul rs11193235 103 9 logistic AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 10 Ul 00004918 076 rs3108066 78 5 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 7 00004922 162 rs7778081 141 2 logistic AGE ₁ SEX microalbuminuria vs no albuminuria (at entry) 7 00004925 146 rs1062492 3 1 logistic macroalbuminuria vs no albuminuria (at entry) 7 00004927 054 rs16825024 200 8 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00004927 027 rs10894321 137 3 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 11 00004928 076 rs41509548 94 1 logistic AGE, SEX low glomerular titration rate vs control (at entry) 5 00004928 129 rs4789188 101 5 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 17 0000493 141 rs7567280 186 0 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 2 0000493 079 rs1998617 92 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 6 0000493 149 rs2026739 56 4 logistic low glomerular titration rate vs normal glom filtration rate (follow-up) 9 00004932 136 rs1947414 82 4 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 6 00004932 068 rs4951276 217 2 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (at entry) 1 00004935 065 rs1241929 91 6 logistic albuminuria vs no albuminuria (at entry) 14 00004938 148 rs7111826 46 3 logistic albuminuria vs no albuminuria (follow-up) 11 00004938 075 rs17721390 87 5 logistic macroalbuminuria vs no albuminuria (at entry) 8 00004938 026 rs10800811 204 7 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00004938 074 rs7236339 125 1 logistic albuminuria vs no albuminuria (at entry) 18 00004939 134 rs17638742 52 3 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00004939 078 rs10471462 68 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 5 00004939 061 rs11036538 52 9 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 11 0000494 179

rs4658507 273 5 logistic AGE, SEX albuminuria vs no albuminuria (at entry) 1 00004941 078 rs4737886 83 9 logistic GE, AGE, SEX low glomerular titration rate vs control (follow-up) 8 00004942 132 rs12536448 28 9 logistic AGE, SEX microalbuminuria or macroalbuminuπa vs control (follow-up) 7 00004942 071 rs9574869 276 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 13 00004944 070 rs12590408 92 8 logistic low glomerular fitration rate vs control (at entry) 14 00004947 069 rs7236642 49 7 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 18 00004947 148 rs16870406 101 7 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 6 00004948 268 rs7874519 56 1 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00004948 134 rs445511 71 0 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00004949 134 rs7973993 112 5 logistic low glomerular fitration rate vs control (at entry) 12 0000495 179 rs17345528 117 4 logistic microalbuminuria vs no albuminuria (at entry) 3 0000495 134 rs2286385 2 9 logistic GE, AGE, SEX low glomerular fitration rate vs control (at entry) 12 00004953 122 rs17674454 38 5 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 15 00004954 071 rs10518697 38 5 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 15 00004954 071 rs130250 31 1 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 22 00004954 070 rs2503293 111 4 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 6 00004955 076 rs2829585 19 9 logistic macroalbuminuria vs no albuminuria (at entry) 21 00004956 175 rs9393366 39 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 6 00004957 072 rs2513077 62 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 11 00004958 058

Ul rs9669216 96 1 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 12 00004959 061 Ul rs1483737 101 9 logistic macroalbuminuria vs no albuminuria (at entry) 4 0000496 153 rs854537 107 2 logistic HBP, diabetes duration microalbuminuria vs no albuminuria (at entry) 7 00004961 082 rs6809087 41 8 logistic microalbuminuria or macroalbuminuria vs control (at entry) 3 00004961 133 rs16826157 186 9 logistic GE, AGE, SEX albuminuria vs no albuminuria (follow-up) 3 00004962 049 rs11563199 243 9 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 2 00004963 159 rs12035171 103 6 logistic AGE, SEX microalbuminuria vs no albuminuria (at entry) 1 00004963 076 rs11174249 73 9 logistic low glomerular fitration rate vs control (at entry) 12 00004964 052 rs1490319 56 0 logistic GE, AGE, SEX low creatinine clearance vs normal creatinine clearance 9 00004967 133 rs7114320 53 7 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 11 00004968 134 rs10482872 4 4 logistic GE, AGE, SEX microalbuminuria vs no albuminuria (at entry) 21 00004969 195 rs4726116 163 9 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00004969 074 rs4303932 158 5 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00004969 131 rs6015452 95 6 logistic low glomerular fitration rate vs normal glom filtration rate (follow-up) 20 00004973 215 rs10193182 80 0 logistic microalbuminuria or macroalbuminuria vs control (at entry) 2 00004973 075 rs11210617 72 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 1 00004974 071 rs1254947 149 2 logistic albuminuria vs no albuminuria (at entry) 10 00004974 127 rs1379181 72 1 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00004974 144 rs6944568 3 1 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 7 00004975 069 rs2023968 3 1 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 7 00004975 069 rs35774871 77 8 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 17 00004976 149

rs4128658 63 5 logistic AGE, SEX albuminuria vs no albuminuria (follow-up) 17 00004976 074 rs4775711 45 0 logistic GE, AGE, SEX macroalbuminuria vs no albuminuria (at entry) 15 00004976 064 rs10048138 107 6 logistic GE ₁ AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (follow-up) 16 00004976 162 rs2003013 110 8 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 11 00004977 035 rs7753473 39 6 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 6 00004977 080 rs 17036537 71 3 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 2 00004977 061 rs6600358 71 3 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 1 00004979 077 rs 158687 97 0 logistic GE ₁ AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 9 00004979 072 rs2173577 94 1 logistic AGE, SEX macroalbuminuria vs no albuminuria (at entry) 8 0000498 161 rs4420537 38 6 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 16 00004981 165 rs1861620 202 0 logistic AGE, SEX low glomerular fitration rate vs control (at entry) 2 00004981 078 rs12536448 28 9 logistic microalbuminuria or macroalbuminuria vs control (follow-up) 7 00004981 071 rs9498737 103 2 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 6 00004982 130 rs11025959 27 5 logistic low creatinine clearance vs normal creatinine clearance 11 00004982 072 rs12617566 169 2 logistic microalbuminuria vs no albuminuria (at entry) 2 00004982 143 rs12672060 90 6 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 7 00004984 078 rs17134275 108 2 logistic AGE ₁ SEX low glomerular fitration rate vs normal glom filtration rate (follow-up) 5 00004985 196 rs7638518 172 2 logistic macroalbuminuria vs no albuminuria (at entry) 3 00004985 168 rs292071 43 4 logistic AGE, SEX low glomerular fitration rate vs control (follow-up) 4 00004988 065 rs1364406 142 5 logistic AGE ₁ SEX microalbuminuria or macroalbuminuria vs control (at entry) 7 00004989 076

Ul rs4422395 81 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 4 0000499 145 rs4864949 66 0 logistic GE, AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 4 00004991 074 rs17128987 554 logistic AGE, SEX microalbuminuria or macroalbuminuria vs control (at entry) 12 00004992 219 rs7071067 81 9 logistic low glomerular fitration rate vs control (at entry) 10 00004993 145 rs10822584 81 9 logistic low glomerular fitration rate vs control (at entry) 10 00004993 145 rs9875156 117 2 logistic GE ₁ AGE ₁ SEX albuminuria vs no albuminuria (at entry) 3 00004993 126 rs2367289 81 4 logistic GE ₁ AGE, SEX albuminuria vs no albuminuria (follow-up) 4 00004994 131 rs13240269 66 4 logistic albuminuria vs no albuminuria (at entry) 7 00004996 132 rs10845092 20 4 logistic GE, AGE, SEX albuminuria vs no albuminuria (at entry) 12 00004996 038 rs2885865 80 4 logistic HBP microalbuminuria vs no albuminuria (at entry) 3 00004996 077 rs17566918 504 logistic GE, AGE, SEX low glomerular fitration rate vs control (follow-up) 13 00004997 157 rs1289409 92 8 logistic low glomerular titration rate vs control (at entry) 14 00004998 069 rs931120 131 3 logistic albuminuria vs no albuminuria (follow-up) 5 00004998 137 rs7585499 250 5 logistic AGE, SEX low creatinine clearance vs normal creatinine clearance 2 00004998 078

Table 8 dbSNP RS ID Flank rsl0460712 AGAACATCTGCTCAAT[G/T]ACCGTGAGGAAGGAAG rsll630273 CAACCCATGGTCTAGG[C/T]ACTTTGGAGTAGCACC rsl2346176 CTAAGAAATTTATTCC[C/T]CAATTAGGCAGCATTT rsl7272796 CTTACATTCTCTAATA[C/T]GAGTTGAGGTGCCTAG rslll01370 GGATTCATGGCACTTA[CZT]GTAAGACACATACCCA rsl2301748 GGATTCTGGCTAMTC[AZG]ACCTAACAGAATTCTT rsl550539 GGCAAACTCACCAAGA[C/T]GGGAGACAGATTAGTC rsl490319 GGCACAATATCCATCAIA/GITGAATTTGCCCGCTTG rsl2138732 GGCACACTGCGCCAAA[C/T]GGGCACTG AGCGGGCA rsl814538 GGCACTGTTGAAGGAA[CZT]TGCTCTATTTTCAACA rsl0934313 GGCCTCAACAAACTAG[C/T]CATGCTGTAAAGAAAG rsl636307 GGCCTTTATTATCTGA[G/T]CCTTTCCTGTGTATGA rsl2192108 GGCTGGAGGTTTTCAC[A/G]CCTGGTAGTCTCATGT rsl0254929 GGGAATAGCTGCATGA[C/T]CATAAGCAAGTTTCAG rsl344311 GGGAATATCAGTGTTC[A/G]ATCAGTAAGGATGGCC rsl0430114 GGGATCAGGAAGGTGGIG/TlACTCTG I I I I IATGAG rsl2257494 GGGCCACGGACTCCAC[CZT]GGAACTGATGGGCTGG rsll857247 GGGCCCACTGCAAGAA[CZT]AAGTACTCAATGAGCA rsl6960210 GGGCCCCCTAAATGCC[AZG]GAGCTACGGAGATACA rsl2120173 GGGCTCACAGCTACGC[AZC]CAGGGATATGACGTTC rsl7796864 GGGGTTAAACAGGCAG[CZT]CATCTTTTAATGCGAT rsllO81564 GGGGTTTCCTCATCAA[AZG]TCCAAGGCCATTTCCC rsl507216 GGGTAAAGATAGGTCA[CZG]ATGAAGTAATCTCCGC rsl7622224 GGGTGGTGTTTGCATA[AZG]GAAGGCGAATGAACAA rsl7568979 GGTAAATTAAGAAATA[CZG]CATAGCTGCAGATGTT rsl548445 GGTACTGAAGTGGCTA[CZT]GAAAACAACAACAGCT rsl028050 GGTCCTGGGGCTCTAA[AZC]GGTAGTAGGGGCTCTA rslO865331 GGTGCCGTATCTACCA[AZG]GTGGTCAAGCTGATGC rslOO7O326 GGTGGGTGTTTCCATA[CZG]CATACTGGCATCATTG rsl0733459 GGTTAGATTCTCACAA[AZG]GCTTCATTTAAGGTGT rsl3390257 GGTTCAGGTGGCTTCT[CZT]AAATCTCTGTGTTCAA rsl7095305 GGTTCTCAGATGAAGA[AZG]GTCATAAGCTACCTGG rsl526591 GGTTTGTGTGTACTTA[GZT]CTAATTTTTAAAGAAG rslO7582O2 GTAAACAAGAAGCTAC[AZG]ATGCAAGTATAGAGGT rsl2710732 GTAAAGGATGGTAGTA[AZG]CTCTCAAAGACGTTTT rsl6919323 GTAAATGAAGTTTAAC[AZG]GGAACATGATCACACC rsl7600042 GTAAATGTTTCGAGTA[CZT]GTTATTGGGCTCCATT rsl836847 GTAACAGATTTATGGA[CZT]GGATGTGATCCTGGAC rsl061860 GTAATTGTCCTCAAAT[CZT]AGAGAACACTGGGTGG rsl7824255 GTACCTGCCTCCAAAA[CZT]AGAAAGTTCATTTTCA rsll23025 GTACTGGGATGAAAAC[AZG]GATGGCCCCTACTCTT rsll233277 GTAGAGATGCTTAAAA[CZT]TGATGAATCAAGAGAT rsl912108 GTAGATGATCTATTAG[AZC]AACAAAGTGTCTGCCA rsl6968126 GTAGCAAGACCACTTA[CZT]GGATGGCTAAAATGTG

rslll85172 GTAGCCGTTAAGCTCC[A/G]CAAATCACATTTAATC rslOO43682 GTAGCTAATGTAAGTT[C/G]AAATATGTCCTACAAA rsl0106008 GTAGGAGTTTGCAAGAIA/GJAGTAGTTCTGAAGATC rsl364359 GTATAATTTTATGATA[C/G]ACCACAATAAAACAGA rsl6953806 ACTTTGCTTTAGGGCA[C/T]ATGGTTAAGGAGTGGC rsl0521324 CCTTTTCACATAAAAA[A/G]TCCGAGGGTCAAACAC rsl455857 GTCAGGATGCATTTCAIA/GJAATCATGAGAAAGAAG rsl002170 GTCAGGGACTTAGCAC[C/T]GTGATCATGATTGTCA rsl7411195 GTCAGTTTGATTGGCT[G/T]AACTAATAGTCTTCAC rsl7076531 GTCATCATATTGGCAA[A/G]AGACTGTCTAACTAGA rsllO42851 GTCCCGATCACTCTAA[C/T]GTTTGTGTGTCTACGC rsl7805954 GTCCTCACCTGTATTC[A/C]AATGTATCCAAGTTAA rsl7157227 GTCGATGGGACACTAC[A/G]AAAGGCATGAAAGCGG rsl3250299 GTCTAGAACTACAGAC[A/G]CGGTAATCATGTGCCT rsl0803476 GTCTATGCTCTGAACA[C/T]TGGACCATACAGCCTG rsl7101871 GTCTGAACAACAGTCAIC/TIATAGCTATCTCTGCAG rsl504070 GTCTGACAGGAGATAA[C/T]TGGACACTTTTGGGGG rsll652482 GTGACAACCAAAAATAIC/GJGTCCAAAGATTGCCAT rsl30250 GTGATGGTTGGAGAAA[C/T]GGGCACCTGGCTTTAA rslll66629 GTGCAGGATTTGCGTC[C/T]GAATTTCTTACCCTTG rsl2983573 GTGCAGTGCTGCTGTC[A/G]ATGTTGATGTTAATTT rsl6901596 GTGCTGG AGTAATAGG [C/T]CAAATGTATCATGGCC rsl254947 GTGCTTGCTGTCTCCA[C/T]TAGTAATATGTCTATA rsl2052673 GTGGCATAAAGGTTCA[G/T]ATTATTTTAGTCTACA rsl062492 GTGGCTGCTGAACAGC[C/T]GCAAACCATCTTCACC rsll69752 GTGGGGTAGATAGTTA[A/T]ATATGTTTGCCACCTT rsl865977 GTGGTAAGATCTGACA[G/T]TCAAGAAAGCAACCAA rsl7115571 GTGTAATTGTAAAATAtC/TjGGCACTAGAGAAATTG rsl83117 GTTATAGAAGAAGAAA[C/T]GAGACTCAGCATGGTA rsl864964 GTTATGAACAGAGTATIA/GJAGTCCATGAGGGCAAG rsl0063876 GTTCCACCCTATCATC[A/G]ACCATCAGACAGAGGA rsl331484 GTTG AAG ATGTCATGC[A/G]ATGTCAACCTGG AGTT rsl0245556 GTTGTGGGTTGTGTTAIA/CJGAGCAAAAATGAACAG rsl929751 GTTTCAGAAGCTTCCA[A/G]TCACTGACCAATTATT rsl7705657 GTTTCTGCTCTTTCTA[A/C]CGCGTGATAGCGGCGC rslO28767 GTTTTATGATATTCAC[A/G]GTATGGAGAGAGAGGG rsl885290 GTTTTCATCAGTATAA[C/T]GGGAACGATCATGGTA rsl0956801 GTTTTGTGGTTAAAGGIA/GIACATGTTAGAGGAAAT rsl7099250 TAAAACAAGTG CTTTG [A/G]AAACAAATATTCCC AA rsl6952615 AAATATGCATCAGGAA[A/C]TCTAGCGTCTCAGTAA rslll31154 TAAAGAGGCACACTTA[C/G]AAGACATATATGTAAC rsl92598 CGTGAGAATCCTTCCA[A/C]CCTTATTCTGTTGGCC rslO35897 TAAATTGATAGAATCA[C/T]TGAGTAGACATTTCAC rsl7071960 TAACAGGACACTCTCC[A/G]GATTTGGACCCAGAAC rslO845O92 TAACATATGTTGCCTClA/GICTAGCATTAACTACAG rsl571317 TAACATCAATTTCAAA[C/T]AAGGCTGTTCGCAATC rsl6837766 TAACCAAAGATTTTGA[A/G]GCCCATAGCTTTTCTT

rsl500226 TAACTTAGCCTCAGAT[C/T]AGCTATGAGATCTTCA rsl7487422 TAACTTGTGATCATCC[CZT]AATCAAGAACAAAAGT rsl7105368 TAAGAGGTTATGACCC[A/C]AAAATGAACACAAACC rsl3316352 TAAGCACAATATTGAA[C/G]TATAAAAGACATCTTG rsl2685939 TAAGCTGAGGAAACCC[A/G]AGATTCAGCCTTGGCT rsll677065 TAAGTCAGATAAATTA[C/T]GTGCCTGAGGTCAGAG rsl7067875 TAATATGTGCCAACAC[C/T]GGTCCATGCTTTCAAG rsl7005685 TAATTTAACCAGAGTC[AZG]AATTGTCTCGATGAGA rsl537071 TAATTTTGCTTAGAAA[C/T]GCCATGTTTTACTTTG rsl2543318 TACAAATGGCTTTCAT[GZT]AGGAGATGTGTCCTTT rsll735854 TACACATAAGCATTGA[AZG]TATGACAATTGTCAAC rsl6860935 TACACTGGTGTGTATA[A/T]GAACCAAGGTATAATG rsl0787476 TACATACCCGCTGACA[G/T]GAAAGAAAGCAGACCA rsl519729 TACATCAGGTAATCTA[C/T]ACTGAGCTAATGTAGC rsl966908 TACCATTTCAAATTCA[C/G]TATTCAAGCCATATAT rsll949897 TACCTTCTTTTTGGAA[C/T]GCCATAAAAATTACCT rsl6887282 TAGAGGATTACAAAGG[AZC]AGGAATGCTTTAAAAC rsl637931 TAGAGTGAGGATTAAC[A/G]GAGAGCCAGGTGCCTG rsl2407408 TAGATAGGCTGGGTGC[A/G]ATTTCTCATGCCTCTA rslO112627 TAGCAGATGGCACAAA[AZG]TTGCATGCTTAATAAA rsl7528058 TAGCATCCTCCTAAGC[A/G]AAGTCCAGTGCGGCCC rsllO8265O TAGGAAGTTTACAAAC[AZG]AATGAGAAAAATGAGT rsllll9552 TAGGAGACAAAATAGA[C/T]GATGATCAAGGAATCC rsl2030639 TAGGCACTGGGGGATA[C/T]CGTGATGAAGATGAAC rsll510517 TAGGCAGGGTTCCTAG[G/T]ATGAAGACCGGGGATC rsl416079 TAGGTAGATTCTGGTAIA/GIATAGCTGGGAACTATT rsl2590483 TAGGTCCTCTTGAAGA[C/G]AACAGTGATGGTACAT rsl7609252 TAGTGAAAGACAATAA[C/T]AGCAAAACATTGGCAA rsll023705 TAGTGATAGTCCTATC[C/G]AAGAGTTCAAATGGTC rslll74249 TAGTTTGGTAGCTCCA[C/T]GAAGTCTAAGTCTGTT rsl3248311 TATAAAACAGTACATAIA/CJCTCTTCCAGAAAAAGT rsl2814669 TATCATCAGCTACACC[A/G]AACACTCAAGTGTAGC rsl2362410 TATCTAGCCCACAAAA[C/T]ATGGTACCAGTTGAGA rsl6938800 TATCTCAGGATTTTGA[A/G]AGGGCCAAACTAAAGG rsl7479 TATCTGCCTCCCTTCA[A/G]GTTGTAGTCTCTGGAG rsl7796589 TATCTGTTTTACACCA[A/G]TGAAAAGTAGATGCCA rsl980239 TATGCCATTCAGACAT[C/T]AAGGACAAGGGTTTTC rsllO54878 TATGTATAACCTTGAA[C/G]TGTGAAGGCCAGGATC rsl7021632 TATTACTTCATTGAAT[G/T]ACTCTTTGCCATTTTT rslO2236OO TATTCACCAAACTGAT[A/C]AAAAAATCTGCCTGTG rsl2361671 TATTCATTCTGAAAAA[AZT]AGATTGTCCAAACTTA rsl0895090 TATTCTCAGTGTTTTA[A/G]GAGGCACTAAGCCCAT rsl411442 TATTTGTGGGTTCATA[CZG]ATGATnTTCAGATGT rsl0248275 TAI I I I I CGTTTTCAG[A/G]ACATTCAGTTGGTATG rsl2713469 TCAACATTGTTATGTC[C/T]CAGGGAACGAGGAGGC rsl571450 TCAATTTTGAATAAGAtA/TlCAGTGGTGATGTGTGG rslO514925 ACGTAGGACGCCGGCA[CZG]AGAAGGAGCCGGGTGG

rslO8532O8 TCACTGCAAAGGACAT[A/G]AGGCAGCAGGAACTTT rs2023625 TCAGCACTGTGGCAAG[A/G]CTTCTGTGTTCCCAAG rsl6870406 TCAGTGAAGAAACTCA[C/T]GATGGTAGGATTGAGA rsl7566918 TCAGTTCTATGATTAA[C/T]GAGGCATCACCTCTAC rsl379181 TCAGTTGCATAATAAA[C/T]TGCCAAATATTTGAAA rsl7654227 TCATAGAGATGTTTAC[A/G]ATTTGGAAAACTATCC rslO47799 TCATCATGTGACAGAA[C/G]GTTTGTGAGAACTGCT rsl6896723 TCATG AGGGCTTATAG [A/G] AAATATTTGTAATGAG rsl7042372 TCATTCATTTCCTCTA[C/T]GTGATTTGGAGCCCTT rsl2211633 TCATTCCCATCAAGCT[C/T] AGAGGCG AATGCAG AC rslO193792 TCATTGAAAGCAGCTA[C/T]GGGAATATAGGGATCA rsll884584 TCATTGATTGTATTTG[A/C]AGACCTATCrTAATAT rsll61262 TCATTTATTAAAACAC[A/G]GCATGATTAGACCACT rsl7120305 TCATTTCTGTATCTGG[A/G]AGAAAATAGATGCATT rsl2423492 TCCAAAGGGCCTGTAA[C/T]GGATAGTCAATAAATA rsll744184 TCCACTCATTTTCAAC[A/G]CGACTATTGAGAGGAC rsll224427 TCCAGCTTCCATTTCCIA/ClAACACTAAGCTCACTT rsl0904339 TCCATAGACTTGCATCIA/GJAGAGAAGAAGGAGAGG rsl0874849 TCCATGG AGTACTATG [A/C] AGGCATGAAAAG AATG rsl973150 TCCCACTATATTCAAC[C/T]GAGGTGGGCTCTGTCT rsl0978606 TCCCGATAAATCGTGT[A/C]AATTATTTGCTCAGCC rsl0743598 TCCTCAAATGCACAAA[C/T]AATGCAAGGACACAGG rsl7770541 TCCTCCTTCTGTTTAA[C/T]ACATmTCCATCTCA rsll060375 TCCTCTACATTTTCCA[C/T]CTTCTGTTCTGGCAGT rsl7645681 TCCTGCTTCAGTGACA[C/G]CATCAATAATTAAGAA rsl0790444 TCCTTCATTTATTCAC[A/T]CATATTGACTGAGCCT rslO179954 TCCTTGAAAGTCAAGT[C/T]ACTCTCTGATTCTTTA rsl0743140 TCGTAGCCCTCATAAA[A/G]TCATAGTGCAATGCAT rsl7101839 TCTAACCCACTAATCA[C/T]GGTTCTGAATGAGACT rsl0982727 TCTATGTATTAGATAC[G/T]GAATAAATCCATATTT rslll93235 TCTATTAAAAAGGTAG[C/T]CTAAGCTGAGCTGGGG rsl7076524 TCTATTGCTAAGATCA[C/T]GAGTGACACTTTCTTG rsl653782 TCTCCCTTGATGACCA[A/G]CTCTGGTCCTACTGCC rsl0863962 TCTCCTTCCTCCAAAC[A/G]GCTCTAATACTTTCAT rsll829500 TCTCTCTTCTCAGCAG[A/T]ATCAAAGGTAGGCATA rsl548447 TCTGCAGATAAACCAA[A/G]CGTCTCTGACTTTATA rsl0231343 TCTTATGCATATGACA[C/G]ACTGAAGGGGAAAAGC rsll647459 TCTTGATAAATACAAA[A/G]TCATTTCTGCTGTCAC rslllO4736 TCTTGATTCTACCTCA[A/G]TCTACATCTA I I I C I I rsl7271123 TCTTGGAGGAAGGGAC[AZC]CGTATTGAGTTCTGAA rsl3249327 TCTTTCTCTTCTTTGA[A/G]ACAGTCATCATTAATA rsl0746342 TCTTTGACACAGGCTT[A/T]AAAAAAATAAAGAAAG rsl84255 TCTTTGCAATTTTGAA[C/T]CATCTAATTCTACCTA rsl566990 TCTTTGGATCAACCAA[A/T]GTTTAACCCTAACATG rsl0914220 TGAAAAGTCTCAGCAC[A/G]GCGTCAAGCACAGGGT rsl3180 TGAAAGCTGTTTTGGCtC/TIGAAAGTTATGAAAAAA rsl68218 TGAAATATGATGGACAfC/TjGGTGGTAGAAATGTGA

rsl2492701 TGAAATCCTTGAGATA[A/G]GTAAGCTGGTCATGCC rsl0937662 TGAAATGCAGTGAAAT[A/C]ATCCTTGCAGAGAATC rsl7099254 TGAATCAACAACTGAC[C/T]GTATAAAACTATGCTT rsl229979 TG ACTCTAG AATCAAG [A/GJACTTCTATATATGCTG rsl2134140 TGACTGTTGCTCAG AA[C/T]CTAGCTTAAATATCAG rsl0873499 TGAGAATAAGAATCACIC/TJATCCTCAAGACAAGAA rsl 1702528 TG ATG AACTACATTAAfC/T] AAATCACCATCACTGT rsl2702054 TGATGGGTCTCAATAA[A/T]GAACCAATTCCTCTGT rsl0822584 TGATTATTTTCAATGC[A/C]AAGTTTTCTGAGGATT rsl515948 TGATTTGAGCGAGAGAIC/TIAAATAGTGTAGTGTTT rsl0234057 TGCAAAGGAGAAATGAIA/GJGGACACAATAAGAAAA rslO851396 TGCAAATAGATCAGAGIC/GJATATATGGCGAGGGTT rsl7725296 TGCAAGGCACATTCTC[C/G]CAACTAGCTATGTAGG rsll853308 TGCACACATCCGTACA[A/G]GTGTCTCAGGAGCAGT rsl0858809 TGCATTTGTTAAAGGC[C/T]GATGTGCTTCTTAACA rsl0788901 TGCCACCCACπCAAC[A/G]ATGCTCTCTAATCTAG rsl7134277 TGCCTGAGACATGTAC[A/G]ATAAAGCCTGTGATTT rs2034783 TGCTCCTATGAGATCA[A/G]CTTTTTCTAAACAAGT rsl6825798 TGCTGAACAAAATAATIA/CJACCGTCTCAAAAATAA rsl2657171 TGCTGAGTGAACACAA[A/G]CAGTAACCTATGTTCT rslO743138 TGCTGTCTCTAAATTA[A/C]AGCTCTGTTTCCTGGG rslO751O2O TGGAAGCCATGATGCC[A/G]ATTAGCTAACACCAGA rsl878868 TGGCAATAATGGTTAA[C/T]GAATTGAGCAACATCA rsl7078168 TGGCTCATACTCACCA[A/G]GCTGTGTCCAGAGTCT rsl400510 TGGCTCCATTTATCAC[A/G]AACTAGACAGCAATCC rs2041908 TGGCTCCTGCAGCCAA[A/G]TACACTGATGATTTAA rsl2751725 TGGGAGACAGAAATCAIA/GITCCTGAAAGTTGATGA rsl7791802 TGGGAGCCATGCTGCC[A/G]ATTTACCAGACAAAAA rsl0735253 TGGGCTCGGCTATCAGIA/GIACATAGTCGCAACTTT rsll036538 TGGTGGTTGGTTGAAAfA/CJTCTGGAGATTAAGAAA rsl558531 TGGTGTTTTCTCATCA[A/C] AG ATCTGTTCAAATTA rsl3110738 TGGTTTAAAATCAGAAtA/GJGGCTACAATAAAAAAG rsl360411 TGGTTTTCAGCACTAC[A/T]CTTCCTAAGTAATGTT rsll781066 TGTATAATGCAATTAC[A/G]GAATACCTCACTGTGT rsl453183 TGTATG ATATATTG AC [A/G] CAAATCG ATTG ATCAA rsl2944499 TGTATGTCAAATGGAAfC/TjGGAGAATATGGAGAGT rsl7767491 TGTCCTGGATTTTACA[A/G]TCTTTCTGAACCTTGT

TS1510699 TGTCTCCATAGGAACA[C/T]TGTATACCAGGTCTAG rsl7345528 TGTCTCCTTGCCGTTA[A/C]AAGAAAGTAGTGCTGT rsl0880112 TGTCTTAGTTACTGATIA/GJACAGATTAGTGGAGGA rsl647966 TGTCTTGTATCTCTTG [C/T] AGG ATGTATTAGTCAG rsll49851 TGTGGTTAGAGAGTGAIC/TIGGGCTGAAGAGGTTAG rsl470711 TGTGTCTATGCTGTAC[A/G]CTTGACAGTCTCAAAC rsl0749578 TGTGTTAGCAGGCGTA[A/G]AAACAACATTTACCTC rsll54436 TGTTAAATAAATAAACIC/TJAGGCAGAGAAAGACAA rsl363697 TGTTATAAACTGCAAAIA/GJCTAAAAGATAGCAGAG rsl7502345 TGTTTGAAAAAGGTGAIA/GIATTCAATGGCACAATG

rsl422954 TGTTTTCTAATCCATA[A/T]GAGAATTCAGAATTTG rsl7807662 TTAAAGGGACCACAAA[C/T]GCTGGGTCAGTGGACA rslll97169 TTAACATCGAAACATG [G/T]AAGTCTCAGTTACACA rsl530104 TTACACAGGGCCACGT[A/G]AATCACATAAGGAAAT rsl536790 TTACAGCAGATGCAGA[C/G]GTTGAGTAATTTGCTT rsl998617 TTACCAAGTGTATCAA[C/T]GAAAGTGCATTATCAA rsl7137304 TTACCCATGCTCAAAA[C/T]TTAGTATCTTGTTTCA rsl7186040 TTACTTTAAATGTACA[C/G]AACAATCTGGCTAAGT rsl7339036 TTAGAAAATCAGGGAA[A/T]ATCAACATTTGGTCTG rsl558533 TTAGAAACCAGCCACA[A/G]CATTTGGGCACTCCAC rsl3204439 TTAG ATGTAAAGACTG [A/C] AAATTCTAAATAAACA rsl6842040 TTAGCACCACTCTGAA[C/T]TCTGACTTTTCTAGAG rsl7070627 TTATCTCTCCAAACTG [C/T] ATTTC ATTTTAG CAGT rsl345905 TTATTTCCTTCCTGGA[G/T]GCACTGCTTAACGTTT rsl2965571 TTCAAAAAAAGTGTAC[C/T]ATTTCCATCTGATCAG rsl0045387 TTCAAATAATTGAAAA[C/T]GTCAGGAAATTCATAG rsl0275303 TTCAATATGGGTCAGA[C/T]CTCAGCTAAAAGACTG rsl351887 GAGACTTGCAGTGTGA[A/T]AGTAGTAATTTACTCT rsl7597688 TTCATACAGCGGAGTC[A/G]ACATAACATTCATTTG rsl908329 TTCCTCTCCCATTTAC[C/T]AGCGATAGGAGTGGAG rsl7643564 TTCCTG AG AGGTTATG [A/G] AACTGG AAAACATATA rsl0970744 TTCCTGCCTGTAACTT[A/G]AAGGATATCTTCCCCA rsl963640 TTCCTTTTAAACAAAC[C/G]GTAGCATAGTATATGT rsl242558 TTCGAAAACTTTGCAA[A/C]CTCTAAAACGTGAGGA rsl327210 TTCTAGTGCTTCAGAA[G/T]GAATAAAAGGTCATAG rsl7638742 TTCTCTGTCCTTACCA[A/G]GATGATGGTTCTGTTG rsl71500 TTCTGAAGCCATAGTA[C/T]GATGACAAAAAGAATG rsl402337 TTCTGATTATCTGGGA[G/T]AGTGAAGAACTCCAGA rs2035219 TTCTTCACAGTGATAA[C/G]AAGGCAGGATTTGGGA rsl7708673 TTCTTTCCTGCTGGGA[C/T]TATTTCTGATCACAGG rsl861620 TTCTTTCTGTTTTCAGIG/T] AAAAAG ATAG AG ATTA rsl2953319 TTG AAAGCTGTACTGA[C/T] ATTAAAG AATGCATTA rsl7236779 TTGAATTTTCCATGAC[A/G]ACTTCTCACCTGCACT rsl859875 TTGCCTGGGTCTTTCC[A/G]CTGTCAATTCTATTTT rsll69750 TTGGGACCAATAAGTC[A/G]ATCTCCTACTGAAGGT rsl464611 TTGTAATGGTTGTTTC[C/T]CATTCCGGTTGTTTAT rsl334237 TTGTGAAATAACTGTC[C/T]CAGACTCTTCAAAAAT rslO142154 TTGTGCAGTTGACTCA[C/T]TGAAAGGCAAAGGAAG rslO163742 TTGTGTAAGCTATGCA[A/G]CTTCTGGTTCTGTTTA rsl2962651 TTGTTTGTAAACTATC[A/G]GACACTTTTCGTCATA rsl7080277 TTTACACAAG ATGCTG [G/T] AATGCTTATATTTGTG rsl6889712 TTTAGAAACCATGAGA[A/G]GTGAGCATCAGTGGAG rsl0070447 TTTATACACAGATCCA[C/T]GAGGAAGCTGCCTCTT rsl452420 TTTCAAGTCAGGAAAA[G/T]TTCAAAAAGACATGGA rs203948 TTTCAGACATGGTTGT[A/C]AAGAGTCAGCTCCTTG rsl7824261 TTTCAGATAATTGAAAtA/GlACATTTGGGAGTTAAA rsll707121 TTTCAGTACAGAACTC[C/T]ATGGCTGATTAATTTG

rsl866479 TTTCAGTCTTCCTATC[C/T]ATAAAACATGGCTAAC rsll951243 TTTCATCTATCAGTTA[C/G]GAGGCATACATCTTAA rslO781448 TTTCCAGCAAAATTCA[A/G]TAACTAATAGGTGCTT rsl962196 TTTGAGCACTTTTGCA[C/T]TGAGAAAAACAACAAT rs2026739 TTTGG I I I I L I I I GTAIG/TJGCAGGGTACGAGGGAG rsl7427286 TTTGTCAAGAAATCCA[A/G]TAATACATCAGCGACG rsl356704 TTTTACAGATAGAAGAIC/TIGTATACTAAGAAAGAT rsl867876 TTTTAGATACTACAGA[C/T]GAAACACCTAGCATAG rsl6848600 TTTTAGGAGGGAGCAG [A/T] AATAACTATGTATGTC rslll32476 TTTTATCAAACGGCCA[A/G]TAGTAACCATTGCATC rsl0897976 TTTTCGATTTCATCTA[A/C]CACTTCGCTCTAATAA rsll694629 TTTTCTGTACCTCTGA[G/T]AGACAATCACTCAAAA rsl49473 TTTTGAGTCTGCGCTA[C/T]GTGTCACGAACTTGGT rsl430373 TTTTGGAAATCAAGAAfA/GlAAGTATAGGCCATATT rslO13685 TTTTGTGTTTTTCAGGtC/TJAAATAGATTTGTTTTA rsl322051 TTTTTCCAGTACTCCC[C/T]ACTTGACAGCCTCTCA rsl7655355 TTTTTCTTCAAGTTGA[C/G]AGTTTCAGAAAATTGA rsl0495598 CATTGTTCCTTGAGTA[A/C]AAACGAATTAAATTTG rsl0495622 TCTACTATAGCCAAAA[A/G]AAGTTTACTCTGTCAA rslO22377 CTTGGTGCTGGGCAGT[A/G]ACGGTGGAAGTAGCCA rsl0495829 CCAAAACTCTTACCAC[A/G]GCATGCAAATGTCTTC rslO65786 TTCTGGCTACAAAACA[G/T]CTTTTCGTATACAAAC rs 10490114 TTG ATATAAACAGTCTfC/T] ACAATTCAGCTG ATTA rslO193182 CAGCCCCAGGTTCTCC[A/G]GCTAATGGGATTCCAG rsll888061 TTATCTCAGTTTTGTA[A/G]GCCTCAAATCTTTTAA rsl6829733 TAGTATGTGCTTCATAIC/GIAGAGGTTGTAAGAATA rsl6838911 GTCTTGTTGGCTAATA[C/T]CAGGCAAGTTTTTCTG rsl397706 TAGCTTCAGCCATGTG[A/G] ATG AAATAAAGG AATT rsl6854563 GCTGTAGCAGGCATTG[A/G]ACTCACTGGCCTAGTG rsl6825771 TGTAGGCAGTGAAAAA[C/T]GCTCCCTAGTTTTATT rsl470413 GCCCACAATTTAGGTA[C/T]GTCTCTGGTAGAAGGA rsl2130167 CCAAGCATTCCTCTAA[C/G]CTATGACAGGCTTTAT rsl663501 GACTAGAGGTCGTTAC[C/T]AAGCCCTTCAGAAGTA rsl000927 GGGGTTCTCTGGGAAA[C/T]CGACTTGGGAAAGGAG rsl7029949 AGCCAGCTGCAGTTGA[C/T]GGGCTCCTTCTCTTCC rslO51O816 CTGAAGAGAGAGTTGA[A/C]GAATTAGGTCCAATAT rsl7071349 CTAAGGTTGAGA ^" nTA[A/G]CACATCACAGATGCAA rslO511345 GGTTGCAATAAAAGAA[C/G]TGATGGCAAATGGACC rslO8O452O CTCTTCTGTGGGAAGC[A/G]AAAACACTGTGCACCT rsl6824208 CATAGACTGATTCCTA[A/C]GTGGAAGGTCAAATCC rsl7753899 GGCATCTTAGCCCTCA[C/T]GCCGTCTGGTGGGTGG rslO513527 TGGTCACAGTAGAAAT[G/T]AAAGTCTCCTCAAGAT rsl393757 AGACATTCATGGATTA[C/T]AGAGAATGACTGTGGA rsl489922 TAGAACCAGAGCAGAAIC/TIGTAGCCTCAGGAAGAA rsl0490803 AGGTTCTACCACATTA[A/G]GCAGTCAAGATAATTT rsl882257 G AAAGTGAG AAGCATG [A/G]GAAAAGCTAGG AAAG A rsl6826157 TCTAACCATATTCTGA[C/T]GTTGTAGAGACAATAG

rslOOO7275 TGTTGCTCTTTAAATG[A/G]AAGCAAACTTGTGTGC rs2035187 CTTAGGGAAGTTCTTA[G/T]CCAGTAAGTTAGAAAG rsl7024965 CTCTGCTTAGAAAAGA[C/T]GCTCAAATGCTCTTTA rsl980892 TCACCAGAAACAAGAC[A/G]CTGAATTGACTGGCAC rsl545074 TTGATAGGTGGATGAAIA/GJTAGACAAGATACATAG rsl509265 CCTGGTTGTGCTGTTA[C/T]GTAGCCTTTCCTTGGT rsl472610 TCTAATTTCCATCATG [C/TJATTCATTTGCATTTTT rsl968378 AAACATTACTAACAAAfA/T] CCATAGTG CAATAAGT rsl461237 AAGTGTATTTACCATC[A/G]AGTTATAAAGCTTTTC rsl57352 TCACGTATGCTGGAGT[A/G]AATAGGAAACTAGAGC rsl202201 CTTCTTGACAACTCTC[A/G]ATGTGCTACTGAGAAA rsl416641 AAGGAAGCTTCACATAIA/GICATTTGAGTTGTTCTT rsl0495244 GGAGGTAAGCTGTATA[C/T]GGACCTTGATCTTCCA rsl379175 CACTGCAATTCCTGTA[A/G]ACACTGCCACCGAATG rsl0495444 GATTGCTTACCTTAAA[A/T]TCTAACCTCAGCTTTG rsl7168478 CCAATGGG ATTG AGTG [A/G JCAAATG CTG G AG AG AA rsll781914 ACCTGAGTGAGATGCC[A/G]AAAAGGTGCTGGAGAC rsl3272473 CATTCCCAGAGCCCCA[C/T]GTAGAGCGTCAGCATC rs2013112 ACAATTTTTAGAGACC[C/T]ACATGACAGTCACAAT rsl400505 CCCAAGATGGGGTGAA[A/C]TTAGCATATCCATGGG rsl2549798 CACACTGAAAAGAAAA[A/C]CCCGTTAGAGACTGGA rsl7721390 GGAATACAGTATCATA[C/G]AGACATGG I I I I I IAT rsl0504846 TGATCACATAGAGTGA[A/G]GTTTGGGAATCTGTAT rsl825443 GGGAAAAGTGTGACGA[C/T]GGTCCAACAAAGAGTT rsl0091527 TCGCATAGTAAATCTG [C/T] AGTTTCCTG AG ACTCA rsl0505349 GTACTCTAGATTCTCT[C/G]AAAAATCCCATGGTTC rsl292081 CTATAAAGTGGCTGCA[C/T]GGATGAGGGACATTAT rslO26847 AAACCAGAATGCTTTC[A/G]CCTAAACTAACACAAC rsl58688 ATCTAAAGAGTTTCCAIA/GIAGAAAGTATTAATTCA rsl58687 AGATCAAACATGAAGAIC/TJGAGGATTAGTTAAGAC rsl6910240 GTCACTCCCTGTCCAA[A/G]TCAAACCTGGATTCTG rsl332457 TGATTAGGAAATGTCAIA/TJGGATACGTCTGTAAAA rsl0786968 GATGTAATATTAGAAC[A/G]CACTGTTTTGCCAGCC rslll8433 TTTTGTTGGTGTATAA[A/G]AGTGCTATGGATTTGA rsl239771 ACCACAATGAAGACCC[A/G]AAGGCGAGAAATGTGA rsl380316 TCTTGACAAATCTGGTIG/TIAGTTCTCAAGGAGTAT rsl459375 AAAGAATTCCTATACC[A/C]ATAAGAGAAAGATACA rsl555157 CAGGTCTGCAGAGGTA[A/C]CTGCTCTTTTGGGGGT rsllO2171O TGCATAGGTCATCAAAIC/GJAGCTGGAAGCCAAGCA rsl0493131 GCTAGAAATTCTGATG[C/T]AATGCCAGGAGACTCT rsl7709552 GTATGGTGAGAAACCA[A/G]CTACGGATTGCTGCAA rsll232346 TGATGGACGAATTAGC[A/T]GCAAGTAAGGTAACTG rsl334811 GCCTCATAGTGATTAA[C/T]GGGTTTGTATAGAAGC rsl514417 GGATGAAGTGAGATAAfC/ηGGCAGGATAGATATAG rsl0460712 AGAACATCTGCTCAAT[G/T]ACCGTGAGGAAGGAAG rs2003013 GATTTGCAATCTGTTA[A/G]CGAGAGCCTACTAAGT rsl3285280 AAAACATTTTAGGCTA[C/T]GACTTAGAGTAAGAAA

rsl2895787 AAAACTACTTTGAGAC[A/G]AATTTCTTAGGCCATC rslll4418 AAAATATATGAAAGCA[AZG]TACTAGAAAAAGTGAG rsl2485415 AAAATATCTGCAGCCA[G/T]TCAAAATACTCTCGTG rsl396247 AAAATTCTTCGAAAAA[A/G]TTATTGCTACTTGACA rsl2407055 AAACAAAAAAACATAC[A/T]CAATATACTG CATCTG rsl3228917 AAACAAGGATCGGAGA[A/C]AGTTACCAAGATCTTG rsl7680996 AAACAGATTGGTCTTA[C/T]GCTATTTCGGAAGTTG rsl2448211 AAACAGCTGCATCCAA[C/T]GTGCTGCACCAGGGCT rsl7043569 AAACAGCTGTCCAAAT[GZT]AGAACCAGCAAAGTAA rsll070285 AAACTCTCCTGCCAAA[C/T]GAAATAGCTATTAGGC rsl0989294 AAACTGTGGCTCCTTT[A/G]AAAGAATAGTTTCTGA rsl7156226 AAACTTGAGATATTCC[AZG]ATTGAGCAAATGAGGA rsll063686 AGCTCACAACACCTAA[A/C]CCAGGCAGTCATGGGT rsl0790175 AAAG AAG AGGTCAACG [A/G] AAGTATG ATAAACTGC rsl0156011 AAAGCCTCCTTTCCTA[A/G]GTCCAACATATCAAAC rs2026692 AAAGGAACTATTCTTC[AZG]CTACACGAGCACTAAA rsl7190154 AAAGG AAGGTG ATATG [A/G] ACAAATG ACTCAGCTC rsl483737 AAAGGGATTGTGAAAAIC/TITGTTAATGAGAAAGCA rsl6848171 AAAGTATAACTGGCTA[C/T]CTGAGAACATTCAATT rsl7099262 AAAGTGTAGGGAGTGAIA/GICAAATCTTTAAAACAG rsl3006847 AAATCAGCTGAACAGG[CZT]CAAACTATTTTCCTAA rsl7649038 AAATGAACACAAATTA[GZT]ATCCATGCTGAATCGG rsl897169 AACACAAAGGCACCTC[CZT]AGGAAATGGGAAGCTA rsl 1696281 AACATTCTGGAACTGC[AZC]AGCCTAGGGCACCGCT rsl 1764407 AACCAAGGATTGCAAA[GZT]TATATACAAGCCAGAA rsl356952 AACCCAGTCTCTTAAC[CZG]ACGACTCATTCTTCAC rsl975980 AACCGTAACTGTACAT[CZG]AGACAGAACTGCCCAA rsl6956216 AACCTCACCTCGTAAA[CZT]AGGTGTTGACTTTTAA rslO188434 AACGTTTAAGATTCAC[CZT]GTCTAAAACACTCATT rsl258241 AACTACCTCTACTAAC[CZT]ACCATCTAAGCATGGA rsl0000497 AACTCCCTCTTCCTTC[CZT]AAAGTTTTGCACCATC rslO96348O AACTGACGGGTGTACA[AZG]TCTCAAAATCCAGTGA rsl0967935 AACTGATCAACATGAC[AZG]GATAAACACAACTCTG rsl7594526 AACTGTCTCAGCCAAA[AZG]AGAAGGCACTAACATG rsl2511845 AACTTAACAGAACTAG[AZT]AAAGAGATCGAAGAAC rslO9222O7 AAGAAAAATTCAGTCA[CZT]ACAAAACAAAGAAAAT rslO467913 AAGACAGGTGATTCAA[CZT]TAATCCTAATACTTGC rsl6851268 AAGAGTGACCCTGGAG[CZT]ACAAAGTAGCAGCAAC rslO162686 AAGATAATGGATTCTA[AZG]CGGAAGAAAGGTCACG rsl2586449 AAGATGTTTTAGTATA[AZC]ATCTTGCATAGCCTGG rsl6853226 AAGCAATTCCAAATGC[AZG]AAGAGAATATCCATTC rsl610562 AAGGCATTAGTGCCTC[CZT]ACTCAACTTGTTGGCT rsl0973581 AAGGTTTGACTAACCT[CZG]ACAAAACGAAGTGAAA rsl7022224 AAGTACTGAATGTAAA[CZG]TTCTCTATCAGCTATC rslO781686 AAGTCAAGAGAGAATC[AZG]AAGTCACAGAAGTAAT rsl7011370 AAGTCACATGACTGGA[AZG]CAGAAAAGAGCCTGTG rsl6917529 AAGTCCGTCAACTACC[AZG]CCTTCCATGTGAACCA

rsll752805 MGTCTCTGGGTCACA[C/T]TAGCCTTTACCATCTT rs2013004 AATAAATGGTCTCTCA[C/T]GATATTACATCTCCCC rsl730913 AATAATGCATGCAAAG [A/G]CAG AGG ATCATAAAAT rsl7487529 AATACAGTATGATATT[C/G]AAGATGCTGGCTCCTG rsl7097633 TGTCAGTTAGAAGGAAIA/GlACTGGAGGGATACTAT rsl2775879 AATATGTAACACCTAA[A/C]ATGGAGGACTCGACAG rslll77698 AATCAAATGCAGAAGA[A/G]CTTTTTTCTAAGGGAT rsll701920 AATCACAATAATTCAC[C/T]GACCAGCTATAAAATA rsl003980 AATCAGACCAATACAAIC/TJGTACAGGGGACAAAAT rsl2966800 AATGAAAAATTGCAGA[C/G]AGTTTATCTAGCTCAA rsl7021754 AATGAACTTAGGACGAIC/GIAAGGAAAGACTAAGAA rsl766145 AATGCTTGGAGTTACC[A/T]GAAAATTGATTTATTC rsl7031611 AATGTCCCTATCTCAA[C/T]ACCTCTTTGTTCTGCT rsl2826155 CATCCTGACCTGAAGT[A/G]AACTTTGGGTACACAG rsl7042290 AATTAGAAAACACTGA[C/T]GTAAATGGTATCTTTC rsl549332 AATTGGCGTAAGGACC[A/G]AAAGAGACATTATGTA rsl7119427 AATTGTATTTTAAACA[A/C]GGAACCTGCATCAGCA rsl2458118 AATTTTGAGGTGATAC[A/T]AGCATTTAGTCCAAAG rsl551391 ACAAAGAATGTTAGCA[C/T]CCAAGCTCAAGAACGG rslll29937 ACAACAGTGAACTAAA[A/G]CAGGTAGAAGTGAGTC rsl0034306 ACAATGCAGCTTTATA[C/T]GTTTCTAAGCATTGCC rsllO37175 ACACACCCACTTTCAC[G/T]GCACTATTCTATCTCA rsl558532 ACACAGTTGCTGAGTC[G/T]GAAGAGGGGGAAAGCT rslO978612 ACACCATAATTAAAAA[A/G]TTGGTCATTTGTTCCA rsll586374 ACACTTGGGAGCAAAA[G/T]GATTAAGGGCGGCTCT rsl7334370 ACAGCTTCCATπTAC[C/T]CATCATCCCCATTTTG rslO8596O9 ACAGGCAGTGTGGTGA[A/G]AAGTGCGAGGAGCCCA rslO817737 ACAGTAGGTAGAAAAT[A/C]AAGGCCTGACTGACTT rsl6863056 ACATAAATCATCAAGAfA/CjAGTATGTAGAAGTATA rsl0963792 ACATAAGGAACTTAAA[C/T]TGAGCAAGCAAAAAAC rsl469999 ACATGCACCTGTCTGA[A/G]ATGGAGAGCTGAGCTG rsl7204962 ACATTGATATGATAAAIA/GJTGCAGTTTAAAGAATT rslO77514 ACCAATCAGTTTAATC[A/G]GAGAAGAATAACTTTG rsl529289 ACCAATGTTAACAAGA[A/C]CCTTCATTCTCTCTAT rsl3271014 ACCAGCTCTCTCCGAA[C/T]TGCCAGATCTACCTCT rsl7128987 ACCCCTCAACCCCTGC[A/C]AAACTCAAGAATTATA rsl7025554 ACCCTGCAGGAGATTC[A/G]CTACAGCAGAAGGCAT rsll252292 ACCGTGAAGCTATAAA[A/G]TTTAAGGCATTTTTGG rsllO24782 ACCTACAATGAGAGAAIA/GJAGTACATCAAAAGGAA rsl765635 ACCTCTGCCTCCTTTA[C/T]CTGTCTCCCTCTGAGC rsl940893 ACCTTCAACAACTTCC[A/G]ATGGTTTACTAAATTA rsl0738743 ACCTTGCCAGCGAGAA[C/T]TTAAAATGGTTCAATC rsl7399090 ACCTTTCTACAAGCAT[A/G]AGAAGCAATTAAAACT rsl545741 ACACGTAATTTACTTC[C/T]AACTGTTATCCAAGGA rsl2127748 ACGTGG ATGTG AGGTA[C/T]GTTACCAAATAACTTC rsl6889748 ACTAAAATATGATGAC[A/G]AATCTTCTTCAGCCAT rsl0915955 ACTAAGACTGATTCAA[A/G]AATTTAAGGACATTTA

rsl2303755 TACGTAAAAGAAATGAIA/TJCTAGAGCAGCAGTCCT rsl445675 ACTCACCTCTTTAAGA[A/G]ACTAGAGGGAGAAAAA rslO812364 ACTCAGTGTCTGGTGA[A/G]GTTTACTTGCTGGTTC rsl2188581 ACTCCAAGTGTGATTA[C/T]GGAAGAGTGACATGTA rs2023968 ACTCTAGAATCCAAAC[A/G]ATAACTCACTTGACTC rslO153433 ACTGAATTTATGCTGA[C/T]GTGACTATAATCTTCA rsl434727 ATAATACTAACATTGA[A/G]AAATGGCTTCCAAGCA rslO455O38 ACTGGTTTATTGTTAA[C/T]AGGGCTCTCCGGGTCG rsl0867190 ACTGTCTTTTCAAGCA[A/G]GTTCAAACAAGCCTGA rsl0079980 ACTTAGAAGGTAGTGA[C/T]CCAATCTCTCAGTGAT rsllO56174 ACTTCAAAGATTTAGG[A/G]AGATTAGCACTTCAAT rsl6902186 ACTTCTCCCAAAGGTT[A/G] AAATTCTCTG CTCTAT rsl2595945 ACTTTAAAAACGAGAA[C/T]TGGAACTGTCTCCCAC rsl3300278 ACTTTAACAGTAGTGC[C/T]CGTTTTGGTTCATGAA rsl563734 ACTTTCTGCTTTTGGA[C/T]GTATAAGCACAGCGTG rs2009333 ACTTTGCAAATGAGAC[C/T]GCTGACTTCCAGAGAG rsll957907 AGAAAATTGGATGAAAIC/GITATTTTGTGTATAGAG rsl7492851 AGAAATAGAACTTGCA[G/T]AGTAAGCGAAAACAGT rsl2603115 AGAAATGGAGTTTGAGtA/GlAAAAGGATTAGGATTC rsl2911453 AGAATCCCATCTTAAA[A/G]ACCCCAGGGCCAGGTG rsll886084 AGAATGGCTAAAGAGA[C/T]AACCCAGATGCTAGGG rsl860192 AGACCGGCACCATTTC[A/G]CGGGGTGTTAAGAAAA rsll848645 AGAGAAAATTAAAACA[G/T]TGTTGGCCAAGAATGC rsl588213 AGAGTAATTATCCAAA[A/T]ATCCCAATGGAGCCTA rsl896319 ACTTGCATATTTATAA[C/T] AGGTACGTAGCAGTAT rsl241940 AGATACACCTAGAAAC[A/C]CATATACTAGCTGTCC rsl7134275 AGATATATTAAGTGCC[A/G]ATTAAGTCCAGTTGGA rsll010400 AGATGGTTATATGACC[C/T]CAATTGCAAAGATGAT rsl2405120 AGATTCTGCACTTTGA[C/T]GGAAGGAGTTAGAAAA rsl726392 TCATTGCTTAGCTTAG[A/G] ATTTG ACTG AAGAG AC rsl549840 AGCACATCCTATTCTC[C/T]AGTCCCGCGGGCGGCT rsll720604 AGCAGTGTGTTTAGAT[C/T]AGGCTTGGTCACGTAT rsl258246 AGCATGGGCCTGAATC[A/C]AAAATGACTGGCATTC rsl344361 CAAAGGATCTTTAGAC[C/T]GCACCTGAAGGGAGAG rsll216633 AGCG AATACCAAATTC[C/G]AAATACCGGG AACCTG rslO897118 AGCGCATGTAAGGCTA[C/T]AGTTGTCAGCCAGGAT rsl3015251 AGCGTAAATACATGAA[C/T]GCTTCTGCTTACAAGT rsl933002 AGCTATTGATCAGGAA[A/G]GTGAGATCAGCTATCC rsl711001 AGCTCTTTGAAATACA[A/G]ATCCAACAAGGCCCTC rsl947414 AGCTTAGGAATGGTAA[A/C]GCTTCATTGAATTAAA rsl961016 AGCTTCCACATAGCAA[A/G]ATAAATTACCAAGGCA rs2031654 AGGAAATGTAGTTTCA[C/G]GAAAGGAATTTGACAC rs2024476 AGG AATTTG AGGTAAG [A/C]CAATCAGGTAAAGTTC rsllll9981 AGGACCCGCGTGTATG[C/T]ATAGTGGGGGGCAGAT rslO238177 AGGATAAAACCATCAC[A/C]GGAAGAATAAGTTCAA rslO814269 AGGATAGCACAGTATG[A/G]AAAGGCCATGCTTATC rsl647965 AGGCATTTTAAGGAAA[C/T]CGATCTTGGTGTGTTC

rsl68965 AGGCCTCACAATTAAA[A/G]CTGACTACAAAAAGAA rsl94781 AGGCGCAATGATTTTA[CA]GGTAGAGGTGCTTTTG rsl0071774 AGGGCCTTATGTGTTA[C/T]GTTAAGCACCAGGAAC rslll68421 AGGGCTCTGCTGCTCT[G/T]AGACCCAAGTTAAATC rsl7154065 AGGTCTTCGGGGTTTC[C/T]ATCTGAGGGTGTATGA rsl2656061 AGGTGATGGTAACCCA[A/C]TGAGTTTGATATTATT rsl6825731 AGGTGTTTGTTACGCA[A/G]TGATGACTAAGATACA rsl7343615 AGTAGGGATGGCTCCA[C/T]TACACATTGGAGGTTG rslll25629 AGTCCCTGGGTGAACA[A/G]TGATGTCTTGGTTTTA rsl30834 AGTGACAAGGTCTGCA[C/T]CTTAAAAGTTCTCATT rslO114374 AGTGAGAGAACATGTA[G/T]AAGGCAGGCCTGGCAC rsl3273013 AGTGATAGAAATAACA[C/T]TGTATCTGGGTTCATT rsl2568218 AGTGATATTGTCAGGA[C/G]TAGAGATCAGAACTGG rsll253562 AGTTAATTCACTCTCC[C/T]AGCAACCACACAACAG rsl2002851 AGTTATCGTGAAACCC[A/G]GCATTCATAAAAGCAG rsl50409 AGTTCTGGCAAACTAA[C/T]AGAATCCTTAAACACA rslO898O15 AGTTGAGGTTATGAAC[A/C]AATTCACCTATGAGCT rsl7686287 ATAAAAGGATAACAGA[C/T]GAGGCAACAAATTGCC rsll027539 ATAAAAGTATGCATAAIA/GJCAACAAGCATAAGTAT rsl0105587 ATAAACAAGCTGTTCC[A/G]ACTTTTGAACAAATCC rsl3354373 ATAAAGGATAGATAAAIA/GJAAGTGAAGCAAACTAA rsll595123 ATAAATTTAAGAGAGCIA/GICGGCAGGTTTTGGAAT rsl361196 ATAACCTAGATAGATG[A/G]AAAACCATTATTTCTG rsl7053174 ATACACAAGTGCTACG[A/T]ATGTACAAAGACATCT rslO894321 ATACTAACTATATGTAIC/TIGCAGAAATGCTCAAAT rsl6863926 ATACTTGTAAGACTCA[A/G]ATAAGATCATATGTGT rsl0489628 CTAAGCACTTGGCTTG [C/T] AATTGATTG ATAATTC rsll027538 ATATAGATTTGATATG[C/T]AAACCCTGATTTGTTA rsll223077 ATCAACTGTTATAACC[A/G]GACTGTGACTACGGCA rsll927384 ATCAGATGGTATTTGT[C/T]AACTTACTGCTCTGAA rsl0077522 ATCAGGTCATCTGGAC[A/G]AATCTTGAAACACATT rslO867195 ATCATCCACCAAGCAG[A/G]CATCTTTCCTGAGAAG rsl3013563 ATCCCTGATCATTCAA[A/G]GCATTGCTTCTTCACA rslO471462 ATCCCTGCAAGACCAT[C/T]AATGTAATGAACAGAA rsl453654 ATCCTTGATATACCCA[C/T]GTCAATCTTACAAAAG rsl571567 ATCTATCTGGTAGAGG[C/T]CACGGATTTAGTTAAA rsl3008483 ATCTCTCTGTCTCAGC[A/G]CTACATACGAAGCTCC rsl6953054 ATCTGAAGAGTGGTAA[C/T]TCCAATTATTTGCAGT rsll027540 ATCTGCATAATTGTAA[A/C]AATACGAACTGTCAAG rsl6828691 ATCTTGTATTCTTGTA[C/T]GATCACAAGCCAGGAG rsl7242747 ATGACAGTAAGGATAA[C/G]ATAAACTGCAGATGCT rsl0967436 ATGAGAACGCAGGGGA[A/G]ATGTCAGGTACTTATC rsl507727 ATGAGCTAAGCTTTAA[G/T]ACAGAGTTGGGTTCAT rslO11275 ATGATCAATCCTTTAA[A/C]AACCAAGTATGTATTA rsll609178 ATGATCTGCTCTGAAA[C/T]AGCCTCACAAACTCTC rsl2895324 ATGCACAGCACGGTTG[C/T]AGA I I I I I AACATTAG rsl0749550 ATGCAGGAAGGGCACAIA/GJGATAAGGCATAGGCAG

rsl806753 ATGCATATAAAGTGCC[A/C]AACAGAGATCCTGCCA rsl647786 ATGCTAGCTCATCAAA[C/G]AGAATTAACTACAGTA rsl84977 ATGGCTACAGG ATTTG [CZT] ATTTCG AAAATTCAGT rsl57676 ATGGGCTAGTTTGAGG[A/G]AI I I I I CAGTGGTGTT rslll30850 ATGGGGCTATTGATGC[A/G]GATTGAATTTGCAGAG rsl2616972 ATGGTAGACAGTGAAA[C/T]TCATATCTATAAAAAT rsl523890 ATGTCTCATTTTGCTC[C/T]CTTTGCATATTGCCCT rsl898445 ATGTGAAAACTTTTCC[CZT]GATAATGAATCTCTGC rsll815121 ATGTTAGAGGTTGTTA[CZT]ACACTTTGGATCCCAG rsl697559 ATGTTCAATATCATCC[A/G]ATAAGTGGTTTGGAAA rsl3153675 ATTAACAGGGAGAAAA[CZG]TTGCATTAAGAATAGG rsl7492893 ATTAATCCCTTCCAAA[A/G]TTTG CAAAACC ACTAA rslll56316 ATTAGTGGGTATGTGG[AZT]AGAATTGAGTTATCTG rsl7737516 ATTATACCATAGGTGG[A/G]ATCAATTTCATACAAC rsl455593 ATTATCCAAATATCAG [C/T]CCAGTACTTGGCATAT rsl932604 ATTATTTGCCCAGACA[A/C]TGATTATACAGATGAA rsl2642691 ATTCTTCCAAAGTTAC[C/T]ATTCTTGCCAGTTTAC rslO178115 ATTGACTTGTTAATGC[A/C]AACTGAAGAGTTGAGG rsl533931 ATTGATAGTGAGCCAC[A/G]CATTCAGTCAATCAAC rsl466122 ATTTGαGTTTATCCC[A/G]AGAGTGGCTAAGATGT rslll52369 ATTTTGTACGGTTTTC[A/C]CTTACATCCTTTCTAT rsl0742654 A I I I I I I I AAGAAATA[CZT]GGTACAGATCAGTTGA rsl812582 C AAAC ATCTGTAAC AA [A/G]TG CTAC AATC AAAC AT rsl400512 CAAATATGGATTGCTT[AZT]AAAATTATTGAATTCT rsll49853 CAAATCCTCCATGAAC[AZC]ATAAACACACCTCTTT rsl729975 CAAATTTCTTAACCTA[A/C] CAACTCTG CATCAAGA rsll630273 CAACCCATGGTCTAGG[C/T]ACTTTGGAGTAGCACC rsl7678704 CAAGAACATAGACAGA[C/G]GATCATGCTTTCATTT rsl529579 CAAGACATCGGTATCA[GZT]GGGCAACTAGTCCAAG rsl7267585 CAAGAGTCTCGTTACA[A/T]TAACCTCCTTGCTTCA rsl2258211 CAAGTCTGTTTGAGAG[A/G]AGTTTGTTCCATAGCT rsl2418662 CAATCTGGCTATTGAA[A/G]TGTAAACACAGAAGTA rsl364406 CAATGTTAAGCACAGA[CZG]AGTTGAGTAGCTTCTT rsl7446325 CAATTGTACTTTTGGAIA/GITCATAGGTTAGAAGGA rsl94782 CACACATGTATAGACA[CZG]ACATACAACCTTCCCA rsll674444 CACATCCATCTCTGTA[AZG]GGCTAATGTTTCATGT rsll070279 CACATGCTTCCATCCT[AZG]AGATTAAAACTGCAAA rslO843144 CACATGGCTGTAGTAG [CZT]AGTTACTCAGGAGGCT rslO47929 CACATGTGTCACCTCA[CZT]GTGATTCTCACCACAG rsl0107785 CACCATGGATTAGCAA[AZC]CTATTATTTCCAGGAC rsl530211 CACTCATTCTCATCTA[CZT]ATCTGGCAAAGTGCAG rsll838024 CACTCCTGAAGCAAGC[CZG]AGACTACAAACCCACC rsl7006815 CACTCTGGAAAGTAGC[AZC]AATTTGTTTGGAAAAC rsl912278 CACTGGAGAAAATCAA[AZC]GACTGTTCTCTAAGTG rsl6830489 CACTTATGTCAGAGCT[GZT]AAGTCAGTGAACCAAA rsll624722 CACTTGAACAATTGGA[CZT]GTAATAGAAATCTACA rsl2590361 CAGAAGCACCTAAAAC[CZT]GTAGCCCACCTTACAG

rsl0889155 CAGAAGTGTGATATTC[A/G]ATGGAGAGGCAATCCT rslll60417 CAGAGAATCCCTCAAA[C/T]GGCCCATGTTTCTGCC rsl379666 CAGAGGGGAAAGCACA[AZG]TAGACAAGGTCAGCCT rslO8OO811 CAGAGGTGAGTAGTTAlC/GlAAAAGAAATCATATGG rsl6939132 CAGAGTTTAGGAGACA[C/T]GCAGGGTCTGTAGGTA rsl539542 CAGCTCCTCTAAGTTG [A/T] ATTTATCAAGG AGACA rsl0233321 CAGCTTCTAAATACTG[A/C]AGAGTGCCAG AGGACT rsl0759765 CAGGACAGATCTAGAA[C/T]AAAAACCAGCGTTCTT rsl764844 CAGGACAGTATTTGGA[C/T]GTTAGGCTTATCAGAC rsl0978601 CAGGACTTAGGTTCAG[CZT]ATGAGGAAAATATCTC rsl6994846 CAGGAGGTCACATCCC[CZT]GAGTTTCCCTGAGTTT rsl0792617 CAGGATAATGCTGTAA[AZG]ATGAGTGTTCAGATAA rslll2094 CAGGCAACAAAAGATC[AZG]AGCATACTACAGGCAA rsll61263 CAGTAGTTAGAATAGA[AZG]ATAAGTTGTGGCTTCA rsl7587689 CAGTATTTTCTGCATC[CZT]CATGAACGGAAGTGAG rsl7767946 CAGTGAGTCGGTGGAA[AZG]AATGAGGATAATGACC rsl7021710 CAGTGCCTCGAACAAA[CZT]GTCAACAGAGCACTCT rsl404868 CAGTTCTGG AATAG AG [AZC]ATATTGATTTATGACA rsll610143 CATAATCATCTAAAAA[CZG]GTTCTTAGAGGAAAAT rsl2960965 CATAATGGACATTTGC[AZG]CCCTTTAAGGAAGTAA rsl545240 CATGACTCACTCAAAA[AZC]CATTTTCAGTCATGGC rsl7763040 CATGATGTCCTAACAA[AZG]CAAATTATCACTTTAA rsl687970 CATGCAGAATGGTGCC[CZT]ACAGTAGGTCAACAAA rsl0953106 CATGGTGTGTGCTTAG[AZG]AAGAGGAAGTGAAGAT rsl7799065 CATGGTTACTAGAATA[AZT]CTGGAAACCTAGAAAA rslOO76 CATGTATTTCTAGTGA[CZT]CAATTCAAATTAGTAC rsl0109797 CATTATGAGAGTTCCC[AZG]AAGGAGAAGAGAGAGA rsll939157 CATTCCTTTTGTCTTC[AZG]AATCATACATCTGTGT rsl2959290 CATTCTTGCACACGAA[AZG]GGTAACAGCATGACCT rsllO24875 CCAAATATCTACAGTA[CZT]GATCTTACCAAATTTT rsl0259269 CCAACTAACTGTGCCC[AZT]ATTTTGACCACAGGGC rsl411441 CCACAGTGAGGCTAAA[CZT]ACCCTGGATCTCTTGG rsl0992063 CCACATCCTGGTTGGA[AZG]TACCCGCAGTAGGGCT rslO816424 CCAGAGTCAGCGCCCA[AZT]TATATTAAATAGAGAG rsl2655096 CCAGGAGCTGAATCAC[CZT]GGCGCTTTCATCTTGG rsl7670198 CCAGTTGGTCCAATGA[AZG]AAAGAGGATTAGATTT rsl520653 CCATCAGTGGATAATG[AZG]AAATACGGTGTCTGTA rslO18O663 CCCAAAGCTACTTTTC[CZT]CTTGTATCCTCGGACT rsl0151731 CCCAACAATGCCGCTA[GZT]GGAATATAGTCCATAT rsl6957020 CCCAAGGTGACCCAGG[AZG]AAAAACAGCTTCCGAG rslll21778 CCCCAACCTGTGTGGA[CZT]GTTTACATAGATCAAT rsl62079 CCCCACCCACTCTCAT[CZT]ACTCTCTAGCCCTCGA rsl2035171 AATCTGCTTTGTGGCT[CZT]AAA I I I I I GCTTCAAG rsll060924 CCCCCTGGATGTGCAA[GZT]TTATCTGTACAGCAAA rsl2527030 CCCCGTGTTATTATTC[CZT]AATTGTACAGGACAGG rsl655131 CCCGTGGAGGACAAGA[CZG]AGGATGCTGGTGGACC rsll712727 CCCTCAGGGCCCTAAC[GZT]AATCTGGCTCCTAGCT

rsl0973014 CCCTGCAAAGTTTCTC[A/C]ACCAACAGTGCAGATA rsl010900 CCCTGCTTGGATACTG [C/T] AG AAAGTTGCAGCTCT rsll097065 CCTCAGTTATATCTTA[C/T]AGAAGTCCTGCCAAGA rsll940741 CCTCCCACTTCCAGCA[C/T]TGAATAAACATGAAGG

TS17154458 CCTCTAATGGAAGAAT[C/T]AGAGCGGGTCCCACAG rsl0857590 CCTCTCAGGAAATAGT[A/G]ACACTTAGGCCCAGAC rsl2617566 CCTCTGGGGTTGGATA[A/G]CTTCTCTTGGCTCAAT rslO78O235 CCTGATCCTCTGTAAA[C/G]CCTTAATGAATGTAAT rsl7737569 CCTGCTTTGGGCACTA[C/T]ATTCCTTTCATGAGCA rsl2535840 CCTGGCAGTTATTGAA[C/G]ATACCGCTCTGTTATG rsl960847 CCTTGCCAGATTTCTC[C/T]ACTCGGTCTATTACCA rsl396512 TCATCTCTCTATCCCC[C/T]GAAACAAACATTTGAG rsl382394 CGAGTTGTGTATCTAA[C/T]TGCTCTCTAGAAGGGC rsl0765796 CGπCATAAATTTCAC[C/T]AAGTCATCAACACAAA rsl7251278 CTAAAGACAGAAGGGC[A/G]ATCTCAAGATACCGAT rsl2346176 CTAAGAAATTTATTCC[C/T]CAATTAGGCAGCATTT rsl2312326 CTAAGTGTGGTTCATG[C/G]ACAGGTAATATCAGCG rsl2489725 CTAATCTACAAAGTAA[C/T]GGTCTTCAGGCTTTGA rsl441511 CTAATCTACATTCCCA[C/G]TGACAATGAAAAAAGG rsll688740 CTAGGCTTGAATGAGA[A/G]AATAACGATACCTTTC rsl0968723 CTAGGTATTCTAATGG [C/G]CAAATCTCTCTTTTCA rsl3413437 CTAGTAAAACTAAAGC[A/G]CTGTAACTAAATTCAT rsl7779263 CTATTCCACTCTAACA[A/G]CAAGCAGGCAGTAATA rsl3438289 CTATTCTATTTAACAC[A/G]GTAACACTGACCCTTC rsll783436 CTCATTTCCTGAAGAC[C/T]CTTCCACCAAAATCTA rsl0048138 CTCCAGGCAGGAGGAC[C/T]ATTGGCCATTTATTGA rslOO58955 CTCCATAAAATTTTTC[A/C]AAAACTAGTGAGCAAA rsllO45415 CTCCCACTTTGGAGAC[A/G]GTAAGCAAGTTAATAC rsl0498537 AAπGATTCCTTAAGA[C/T]TAAAACACACCATATT rslO35898 CTCCTCTCCTCAAATA[G/T]AAGTACTGTGGGTATT rsll803988 CTCCTCTCCTCAGAGA[C/T]TAAAGCGTTTCTCAGG rslO431158 CTCCTGGGACTTTGAA[C/T]GTAAGCATCTTGGCTG rslO31287 CTCGTTCCTTCTGGAClG/ηCTCTATTTCCATCACA rsllO3OOO8 CTCTCAAGCTCTAACA[A/G]TCCTTGTGCTTGGGGA rsl6931308 CTCTCTCATTTTCTCA[A/G]GGAACTCTTCTGCATC rsll93167 CTCTGCCTCG AATCAA[C/T] AG ACTTAATATTTAAT rsl6854019 CTGAATTCAAATCACA[A/G]TCTTCTGTCAACTGAA rsl7696165 CTG ACTCCTTG CTTG G [A/C] ACAGTG AGCTGGCTCG rsl0823420 CTGAGAATAAGAGGAAIC/GJAGAAGATATGAGGGTG rsll720582 CTGAGGGCCATGTTAC[A/G]ATGGAGGAACTGAGGC rsl0897992 CTGATATCTGCTCCAC[A/G]GACGTGTAAAATCACA rsl986877 CTGCATTCAAACACAA[C/T]CCACAGGTCATCTCTA rsl6846031 CTGGAAATAATGATAC[A/C]AACGGCGATCCATTAC rsl510294 CTGGAACTGCCAGGAC[A/G]ATGGTAGCAATTTCAG rsl6849578 CTGGACAGCATTCCAA[A/G]AAGACCATGTGTTCTC rsl2746741 CTGGGGGACACAGTTA[C/T]AGTTACTGAGTGCCTA rsll640993 CTGGTGGTACATACAG[A/G]AACTGGTTTTGGAAGG

rsll951359 CTGTAAACTTCTATAC[G/T]ACTTTGTACCACCCAT rsl2795565 CTGTTCTTAGGCACCA[C/T]AGTCAGTCCATAAACA rsl7272796 CTTACATTCTCTAATA[C/T]GAGTTGAGGTGCCTAG rsl428419 CTTAGAACCTATGCTT[C/G]AAATπCCTGGCTATG rsl857967 CTTATGGTTCCATATA[C/T]CTTGCTGTATTTTCAT rsl0040971 CTTCATCTATCTCTAA[C/T]GTTGTGACAACACTTG rsl2602903 CTTCCGCTGCATCCTC[C/T]ATAAAAACTTAACATG rsl0150355 CTTCTGATTGGAAGAAIC/TIAGTGAATGAGATTGAG rsl0875745 CTTGGGTTCCTGTGAA[A/T]GAATACACATCTCCAC rsllll8204 CTTGGTATTGTTTGTC[A/C]CTTGATTATGGCCTTC rsl0223785 CTTGGTGTTAAATTGC[A/G]CAGAAAATTAGGCTAC rsl678030 GCGTTATAAACACTGC[A/T]CAGTAACTGATACTCA rslll38007 CTTGTGGAATTTGTTA[C/T]AAGGCTTGGTCTCTTG rsl359437 CTTTATGACATCTCAC[A/T]CTGGTCCAGACCAAGA rs2009111 CTTTCACTTCACACTG[A/G]ACCCTACAAATGACGT rsl0800462 CTTTGAACAATGAAGAfA/GlGGAGGAAAAGGTGTCA rslO894319 CTTTTGGAATTGGAAC[C/T]CATATCAGTTATCTTA rsl333996 GAAAACAGACTCATTC[A/G]CCAACAAATAATGGAT rsl413618 GAAAATGTTATCAGGAIA/GJAGCAGGATTAAATAAG rsl2125493 GAAAGAAGCTAATCTGIA/GJAAAGGTCACATAATGT rslO54497 GAAATCAAGTGGCAAAIA/TJATCAGATCTGAGGGAC rsl3095931 GAAATCTGCATTACAA[A/C]ACCCACTACCCTTGTT rsl430377 GAACCCCTCTGTTTTG[C/T]ATTGGCAGGTAATGTG rsl7146098 GAACCCTGAAGAGAAA[A/C]CTAGTGTCTAATTCAA rsl569175 GAAGAGGTATCAATAAIA/GJTAACTTCGATGATGAT rsl2474326 GAAGCCATTATTCACG[C/T]AATTGATGAACTTGGA rsl971990 GAAGTTCAAGTTTCCA[C/G]TGAGTTATGACTGGGC rsl477437 ATTAAACTTGCTAGAA[C/T]TCCTCAGTACTAATAT rsl0867246 GAATGTCTTCATGATqC/ηAAAGGTAAGGAAAGAT rsll897612 GACACCTGACATAGTA[A/G]GCGATAAGTTCTAATA rsl2932741 GACATTCTGTAATCCA[C/T]CCATTTCACTCGTGTT rsl7761559 GACCATTGAGTTAGAC[A/C]CCTGCTTCATGTGGAA rsl0774823 GACCTATGCTCTACAA[C/T]ATTAGAAACAAGCACA rsl2512146 GACCTGAAGGAAAAGA[G/T]TATGATGTAGGCACCT rsl7673703 ATTTCCTGAGTGTCGA[A/G]CCCCATTCCTGCTCAT rsl51052 GACTCTTGAGGGAGAC[C/T]ATCCTGGATTAATCGG rsl6939145 GAGAAAACCAAGGCTC[A/G]AAGTGATAAACTCATT rsl85793 AACTTCTCATCCCGAA[A/T]CTTTTATCAGCTTCCT rsl0890401 GAGCCGGAGATCATCAtC/TJAGAGACAGAGAGAGAT rsl6960516 CATCAGTTTTTCATCA[A/G]GCAAAAGAAATTGAAC rsl6893391 GAGGAAACAAAAGTCC[A/G]AGGTTCACTAAGTAGT rsl6973718 GAGGCTCTGCATCCAG[G/T]AATCCAGGCTTCTAGT rsl94869 GAGGCTGGGGATACCAIC/TJATAGACAGCAGGAAGG rsl7428570 GAGTAATCGCCCAAAA[C/T]AGTGTTTGCCAAAATG rsl2609410 GAGTATCTAGTCAACA[A/T]ATAAGGACCACAAAGT rsl2490544 GAGTATTCTTGTACCC[C/G]CTTCCAGAAAGGACTA rsl6853191 GAGTGACTTGAGTTGAlA/GlTAATAAAATGCTGGTT

rsl918026 GAGTGTTACGTGCTCC[A/G]AACTCCCCATGCTAGA rsl3276054 GAGTTGTCAAAGAGGA[C/G]TCACAGCAGAGGAAAA rsl2055256 GATCATGCCATTCTTA[C/T]GCTTAAAACCCTTCAG rslll44203 GATCCTAGAAAAGTTA[A/G]GTTGTCTTCTTCAAGA rsl289409 GATCTGGATAAACTAA[A/G]TAATCTACAGGCCTTA rsl616442 GATCTGTTCCCTTCAA[C/G]TGGCAGTTTATATGTT rsl0998910 GATGAAAGAGGCACCA[C/T]TGGAATTTACAGCCCA rsl7641512 GATGGAGAAAAGGTCAμ/GjGGAACCGGCAAAGAGG rsl0016434 GATGTATATTATCTCA[A/G]AGACTTACTAGTTTAG rsl7365438 GATGTCCATCACCGAC[A/G]GAGTAAGAGACTAATA rsl0122952 GATGTGGGAGAAGGAAIA/GJGTTGTCCTGGGAATTA rsl2545592 G ATTAG ATGATGCCCG [C/T]CCACATTAAGGAAGG A rsl7559639 GATTCACATAGGAATG[A/C]ATTAACGATGTTAGAA rsl2664845 GATTGAATGTAATTCC[A/G]AGTTAAATTCCAATGA rs2000833 GATTTACAATTACCAA[C/G]CATAAAGTAATATAAA rslO7864O5 GATTTAGTGCCCATGA[C/T]GATGATGAATTATTAG rsl7480167 G ATTTGG AATGTCAAG [G/T] CCTGTTG ATG AATAAC rsl546640 GCAAACTATAGGATACIC/TJGGGTGAAGTGGTTGAT rslO39986O GCAACAGCAGAGTGTA[A/G]GGCAAGATTCCAAGCC rsl472095 GCAATTCGTAAATAAAIA/GJCAAGTGAAAATGGAGA rsl7221260 GCACACCTTTTAGCGG[G/T]AAACCAGACAGAAAAT rsll707973 GCACCTCCTCTGTCCA[A/G]GATATGATGCCAAGTA rsl541749 GCAGCTTTGTGCACTC[A/G]CTGTCTTTGCAAAGTG rsll842662 GCATCAGCTCCTGTTA[A/G]ACCAGATAACCTGGAG rsl7799275 TATTAGAACTCCAAGC[A/G]ATAACTGAATATCAAT rsl7080594 GCATGGCCTTGGGGTA[A/T]TACACTATGCCTAAAG rsl2403846 GCATGTTTCTAAAAAC[A/G]CTTCAGGAATCCAGAG rsll563199 GCATTTGCTGCACTTA[C/T]GTTCTAGTTCATTAAA rsl553953 GCCAACATTCCTCAGA[A/G]GACCACTTGGAAAATC rsll726931 GCCAATTCACAGCTAC[A/G]GCTCCCAATTCTAGCT rsl392695 GCCCAGCTTTCCTCTA[C/T]CTCAGAAATTCTACAT rsl7674454 GCCTCATTTATAAAAC[A/G]CTGGTACGGCCAAACT rsl0736593 GCCTCTTTCAAAACTA[C/G]CTTTCTATGAAGTGAA rsl6884604 GCCTGATTTGGATGGA[A/G]CATTGAAATAAACATC rsll259272 GCCTGTTAAGTGTACA[C/T]AGTTGAAATGCTTTAT rsl7258731 GCTATCGATATTTCCA[A/G]GGGGATTTCATTTATT rsl694594 GCTCTCCAATCCTCTA[A/G]CTTAGTCTGCCTGTTG rsl7782173 GCTCTGGCTTCATTAA[A/C]CATAGTCAGTTTGCGA rs2025445 GCTCTTATTTGCTCTA[C/T]AATGCATACAGGTATA rsl2120893 GCTGCCCTGACACTGC[C/T]GACATTTTCAGATTCC rsl344484 GCTGTCTTTCCCTGCA[C/T]TATTAAGCTTTAACAT rsl2882375 GCTGTTCTTGTGGCCG [C/T] AATATAGG ATATTGGT rsl66412 GCTTTAAACCATGACC[A/C]AAATTTAAGGTCTAGA rsll71556 GGAAATATGTGTGGGC[A/G]AAACTAATGCCTACCC rslll23021 GGAACAAAGCTGGAAAIC/GJGGGCACAAGAATCCTA rsll204592 GGAAGAGAAAGTGGTAtA/GjACCAAGTATGAATGTC rsl544398 GGACAGCTGCATGGCC[A/G]GAGAGGAGCAGTGAGG

rsl0242865 GGACCTTGGCTCCTAA[A/C]TGCTCCAGTCCAGAAG rslll69761 GGACTCCATGGTCCTA[C/T]TAAATATGCCCTAATA rsl6964862 GGAGAGCAACATCCAAIA/ClGGCTGGAAGGCATAAC rslll58758 GGAGCCATTGGGACTA[A/G]ACAATTCCAGAAAAAT rsl0922204 GGAGGATATTAAAGAC[G/T]GAACTACCACAATTTC rsl494137 GGAGGGAACTTGATTCIC/TlGAAGAGAGGATAGGGG rsl035704 GAAAGCTTTATCTACC[G/T]GGAACATTAGCATTTC rsl258323 GGATGTTCTGTTTAGAμ/GlGAAGTTAAGAGCTGAG rsll246628 GGATTTATCCTACAAA[C/G]GCATATAAATGGGAAA rsll200448 GGCCAAAGGGGACATA[A/G]GTCTGAGCCCTGTACC rsl0969027 GGTAAAGAGGACATTA[C/T]CAGCTTATGACGTGCA rslO166268 GTAGACAACCACTCTA[A/T]CAGTCTGTCTGAGGGC rsl7801910 GTAGATTGAGGGAAAC[A/G]CGAATATTTTAGACCA rsl6825024 GTGAAGTATAATTTCC[A/C]ACTTAAGAATTGAGAC rsl2590408 TAAAATCAAATCTCTC[A/G]CTTTCCACAATTGACA rslll50225 TAAGATACTCCACTAG[AZG]AAATCCACCCCAAGAC rsl2672060 TACTGTCCCTCTTTCA[C/T]CAGTATTTAGAAATGG rsl7046481 TAGTAATTATCAATTA[C/T]CATAGCCTTCTTCATT rsl2536448 TATACACCGTGGAACA[C/T]GAGTCATAAAAAACAA rsl966909 TATAGCTCTTTGGTAA[CZT]AACAGAAAGGTCATTT rsl0515043 CTAATCCACATTACAC[C/T]GACTAATTCTGTATCT rsl7818395 AGAAGCTGAGCTCTAC[C/G]GCGGGATAAGATCAGC rsll724319 TCCCCTTTGCCCAAGG[A/G]ATAAAATCCAAATCCC rsl7509991 TGAAACCATGGCTTTA[A/G]ACCTGGGCTATATCCC rsl3282254 TGAGGAACTGACCAGC[A/G]AGGGAGAAAAATACCC rsl6929523 TGATGGGTTCAGGCAAIC/GlTGGAGGAGGAATTTTA rsl378500 TGCAAAAATGATAAAA[CZT]AGAGTTGGGATCAGTC rsl7648942 TGGTATATTAAAAACA[C/T]CACGAAATGTGACCCA rsl2681129 TGTCCAGGGGTGCAAC[A/T]GCTAGGATGTATGGTA rsl7594665 GCTGATCCCTGATAGC[A/G]CAGCTTCACAGAGCAC rsl0503076 CTCTTCTATCTCCTAA[C/G]TATTGACAGAGAACTT rsl930994 TTCAAAGTGGAAATGA[A/T]CTTAACCTTTTATTCA . rslO871383 TTGAATGAGACAACAC[A/G]CTAAATGATATGTAGT rsl2000827 TTTCATTCTGAGATGC[A/G]AAATCATTGAGCAGAA rsl2161700 TTTCTTGAAGCACTCC[C/T]AGATTCTCATAAGCAG rsl0496309 CTGGAATCGTCAAGTC[A/C]ATCCAAAGCAGAAGCT rsl0482872 TAAATTATAAAGCAAA[C/G]TTATAGCCAATTCTCA rsl7031374 TATGTAAGGTGGGCTA[AZG]AGAAATGTTTAAAAAG rsl673887 GTTCACTGATTACTAA[AZG]TCTCAGTACCAAATTC rslO519362 GCTGTTGGTATGTGAA[CZG]AGAGTAAAACTAAAAT rsl0485358 GACTGGGAGAACTTAA[A/G]CCTTGATGAGTGAGAG rsl0485282 GTTATCAATGTCGAAA[C/T]TTGATTAAAACTTAGC rslO485214 TCTTTGGTGGTATTGAlA/ηGAGAAGGAAACTCTAT rsl979096 TCTGCAATGATGTATC[AZT]GACCATTCATGTTCTC rsl218661 AGACTCAAAGATAGAG[A/C]CCAAAAAAGTGACACT rsl0509870 AATAACTCTCAAAAAA[C/T]ATGGTTTCTCTCTTTC rsl0500932 AATAGTTTAACAAGTG[A/G]CAAGAGCTAACAAATG

rslO5O1293 TG ACAAAGTTTACAAG[G/T] AGGG AATCTTGG AGG A rsl603530 CAATTAAAACCGATAA[C/T]AGCAAGGGTTGATGAG rsl0501407 CCCAAAGCAAAGCAAA[CZT]GTAGGACATGAGAGTC rsl0891169 ACAGTGGCAGGTATTC[A/C]CAGAATCAGACAGAAA rsl7056214 AAAATAAAAGGAATCA[AZG]ATTTATCCAGTAGGAT rsl0957769 AAACTATATCCTACAT[A/G]AATGACCCACTATATT rsl6880395 AACTCTGGTGTTGACC[C/T]AGCGGGTAGCATGAGA rsl460540 AAGATCCCACTπTGA[A/C]GTCATTAATTTCCTAT rsl872829 ACGATCAGGTTACAAA[C/T]GCAATACATTAGGGAC rsl408478 CATTATGCACCCGTTT[A/T]TACTTGGTGTCCCACA rsl0858753 ACAAGTTG AATCTGGG [G/T]CAGTGAACACAATGTC rsl7330985 ACACAATGAAATAAAAIA/GITGTGCTCTCACAAGAG

γS11940866 ACAGTTCAGTTGAAGG[G/T]AAGGTCATTTCTTGCC rsl7076442 ACCAAATTACACTGGAlA/GlCAAACAACTGAAGGTC rsl0492295 TCAAAGGAATTTTGCA[CZG]GTATTTACATCTCTCT rsl482047 AGAAACCATACAGAGA[CZT]TCCAGATGTTTGAATT rsll210617 AGAAATGATAAAGACA[AZG]CATTACACCTGACACC rsl7345786 AGACCTTGATGCCCAA[AZC]ACTGGTTATGAGAGCA rsl366354 AGAGGTGGCTGATGGG[AZC]ACCATA I I I I I GTTAG rsl7680905 AGATACAAACCAGATT[CZG]AAAGGATCTTTAATAT rslO28427 AG ATCATCCTTACTAG [AZGJCATAATGGGATTTATA rsl7674649 AGCCGCTGTGTGGCAC[GZT]CTGACAATGCCCTTTA rsl6901597 AGCTCTAATATTTATA[AZG]TACCCACCACGGTTGT rsl7736364 AGGCCATTTTACAGCA[AZC]ACTATGGTCCTTAATC rsl532554 ATCCACAGATGCAGGA[AZG]AGAAGTTGGATAGAAC rsl396678 ATGAAGAAAAATTGGT[GZT]AATAGGCACCAGATAC rsl2539092 ATGTTTCAAATCGTCC[AZG]AGATAATTTTGGCATT rsllO25959 ATTTTAATCCAAGAGA[CZT]GTAACCTTCACCACTG rsl389798 CAAATCAGGGCAAAAA[GZT]TCAACAGCTTCTGCCC rsl2604327 CATGTTAAGGTATTAA[AZC]TGTCCACAATGGAATT rslO77776 CCATTGTAAGGACTCA[AZC]AATCTATACAGGAGGA rsl0493578 AGATTCCATTCAAATA[AZG]CAGGGTCCATTCAAAC rsl0465473 CGGGCAAAGGAAAAAC[AZG]CCCTAGTCATTCCATA rsl776046 CTGTGGAAAAATCTGA[AZG]TACAGCCTGATATTTG rsll648875 CTTAGAACATTTGTAA[CZT]CTGTCTTTCAAATGGT rsl6965001 CTTATCTTCACCTTAT[AZG]AAAGGACCAGTTTAAG rsl0233697 CTTCTTTCAGGATGGA[AZG]AAGGCACTAGAAGAAG rsl7121123 CTTTTGTGCCAACTTA[CZT]CATCTTTGCTTTCCAT rsll245078 GAAATAAGGAGAGACA[AZG]ATAGATTGAACTGCAG rsl3174713 GAAATATTTTATAAAG[AZG]CCACAATAGAGTACCA rsl0259377 GAAGTCATATCAGGAA[AZG]TGGTAGCTTGATACCC rsl7680407 GAAGTGTTAGTGATGA[CZT]GGACAGAAATAGACAA rslO518697 AGTCCCATGGAGAAGA[AZG]TATCAAATGATGAGAC rsllO54588 GAGAGTTCTGCCAGAA[AZG]CTAAGTTCATTCAAAG rsl224674 GATGATCAGAAGTCTA[CZT]GTGTCCTTCAAAAATG rsl7154998 GATCAGTTTTATAAAA[AZG]GATAAGTGGCTTTTCA rsl580434 GATTAGGCTGCCACAA[GZT]GGTCAATTCTTGGTGA

rsl241929 GCAATAGCTCAAAAAA[A/ητTTTTAACACTATGAC rsl8582 AGGTGACTACAAAGCA[A/G]AAGCATGGAATGTCAT rsl6898990 GGAGGTGCTGCACTCA[A/G]TCAGGTGGCTCGGGTG rsl2956604 GGTTAGCAAGTCTTCA[C/T]TAGCATTTTATTTAGA rsl3333226 GTAGCACAGCTGTAGGIA/G] ATATTG ACTCCTCTTC rsll743536 GTAGCTCAGATAGATG [G/T]AG ACCTG AATAAATTT rsl493902 GTAG AGTTG ACTTTTG [A/G]CCTTGTTCCTTGCTAC rsl0500411 CATACTAATTCTCACA[AZG]TGCAAGGAATTTATAC rsl0177595 GTCTAACCAAATCTTC[C/T]ATTTGAGCAATGATCC rs2024447 GTCTTTGCAGG AATAG [A/C] ATAAGAAACAAG AATA rsl861619 GTGAATTGGCCTCGTC[CZT]AGTCCCTTGAAGGTCT rslO128526 GTTGAAAAGAAGTTGA[CZT]GATGTTAGGGATTTTT rsl0884350 GTTGCTCTAAACTGAG[AZG]ATTCCTGGGATATCCT rslO514479 GGCAACATGCTAGAAA[CZT]GATATGATAGGCAAAA rslO748721 TAAAG AAAAACATGGA[A/G]GACTTAGCATTCAG AG rsl2599351 ACTGTGGTGTAGTGAA[A/G]ACAGCCGATAACCACT rs2024055 TACACTG AAATTTTAG [G/T]CCATGTTCACTTATTA rsl765618 TGTTTTTTTAAAAAAA[C/T]GATGTCTGGTGTGAAT rslO2483O5 TATCCTTTCTAGCCCA[A/T]CATGCTTAGATTAAAT rsl7747233 TATTGGAGGAAATAGC[CZT]GCATGATGCCCAGCTC rsl913695 TATTTGTGAATTGCCA[C/T]GCCAAAAGAAAATAAC rslOO2169 TCCCTCCACAG CCACA [C/T] GTTG CTTTTAG CTTG C rsl2045707 TCTATAGGAGAGTTTC[C/T]CTGCAATTAAGCAAAA rsl366355 TCTCTA I I I I I GACCC[A/G] ACTTTCTG CATTTCTA rslll35724 TCTGTTAACGTACCAT[A/G]ATCTGTGCTTCGCTCG rsl2966869 TCTTCCACTTGGTCAT[G/T]AAACAGCCACAGTTCT rsl0124870 TCTTTAAAATCAATCA[A/G]GAAAACTCATTTTATG rsl628249 TGATGAGACCAAGTCA[C/T]GTGCATATGGTGGATT rsll886398 TGATGCTGAATAGTCA[A/G]CAATGCCAACTTTCTG rsll43694 TGATGTTCGGCTATGC[C/T]ACCGACGAGACAGAGG rsll647317 TGCGAGTCGGTGTAGA[AZT]CATGCACCTCAGGGCT rsl0111251 TGGAAAGTGTGATGAA[AZC]TCTATAAAGCAGGGTA rsl0897973 TGGCCTATCATCAACA[C/T]CTTCTGATCATCTAAT rsl0982428 TGTGTACAATGTTTAA[CZT]AAGAGAGAAAGTTTTA rslO773317 TTCCC I I I I I ATAGAA[C/T]GTTCTGATTAGTCACT rsl2508383 TTGCCTATGAGTCTGT[AZG]AAACCAAAGAAAGTAA rsl0128270 TTGGACATTTGCACAA[GZT]AATTAACTTTACCAAT rs2018548 TTTGATCACTGAAATA[C/T]TAAAGTGATACTAAAG rslO934312 TTTTATCCTTTATTTGlA/TlATCCCATTGTTTAGAA

γS10489525 ACTATCTTCTTCCCAA[AZG]TTCACAATATGAGCCA rsl0197305 GTACCATTCACCTCAT[CZG]AGCAAAAAGCTGTGGA rslO489185 TGCTGTTCAAACCAGA[AZC]ACCTTGAAGTCCATAA rsl491757 CAAGTGATGAGAATAC[GZT]ACTAAAACAGTGTTTC rsl0511350 TAGAAAAAAATGTCAA[CZG]GAGTAGGAGGTTGAAG rsl0513360 GAGAGGTGGTACACAT[CZT]AAGATCTATGCTACAT rsl7171382 TTACCCTTTCCCTGAG[AZT]AACATTGTACATATCC rsl612517 GTACCATGACTATAGA[CZT]TCCTCAACCATCTCTT

rsl0499504 ATATGAGAGATTTAATIA/GJAAGTGTTAAGGTATGC rsl0503257 GTTTTACCAATAATCA[A/C]CATAAACCTAAAACTA rsll598494 AGATCCGCATGGGGGC[A/G]CCGCCTCTTGAGCCTG rsl362441 TATAACTTACTGAGTG[A/C]AACAAGTGCCTCTATC rslO5O2O74 TTTCTGATGGCATCTA[C/G]CCTATTACGTTCTATA rslllO9197 AAAGGAGGGAGTAGGG[G/T]AATAGTTAATTGTGTA rsl326837 AAAGTCAI I I I I I GAC[C/T]AAGAAGTTGGAACAAG rsl947417 AACCTTGCGAAATGTC[C/T]AATTTATCAAAATAAT rsl0773982 AACTGCTGTTTGATTC[A/G]AAATGATTCTTTGTGT rslO198583 AAGAAAGTGGTGCAAAIC/TJTTACAGTATGTGTATG rsl965193 AAAAAGAAAAAGAAAAIC/TJTGAGCTTATAGTACAG rsl240385 AAGGCGCTAGAGAGTA[C/T]GACTTGTGGCTGTTAG rsl2446492 AAGTTCTTATTACGCA[A/T]CAGTCACTGTGCTAAG rsl7036537 AATATTTATTTGAGTAIC/TICAGATAAGCTTTGGTA rsl0155009 AATCCTCATCCCCAGC[A/G]AATAATTATTGAGTCC rslO37537 AATGCAAAATAAAAGC[C/T]AACATATCCCAATATC rsl0459785 ACAATGCCCCACATTC[A/T]AGAGTATTCTATCTCC rslO935316 ACACACCAAGCTCATC[C/G]ACCCCAGTATCCCACT rsl3240269 ACACTGGAGTTATTCC[C/T]GCTACAAAGGTTAACC rsl7631610 ACATATGAGCTCATTA[C/T]ATAACTTTGTCATATA rsll219092 ACCGCTGCAAGACCTC[A/G]CATCAGTAATTAAAGT rsll243150 ACCTGTCGACTTTGCC[A/G]CTGTCATGTCCATATA rsl430382 AGACTCAATTTGAGTA[C/T]GCCTTTAAAGTAAGTT rslO152371 AGCACTTATTGGATTA[C/T]CTCGTTTACTCCTCCT rsl872292 AGCTAAGGACTTAGGC[G/T]CTCCCCAATACTATGT rslO54496 AGGACCACGGATTTCA[A/G]CTCCACCCTCATTGCG rsl542481 AGGAGTCAATGTCAAGlA/GlATTTCACAGGGGATAG rsl894898 ATAAGAGACTCTTAAA[A/G]ACTCATTTTGAAAGCC rsl0872387 ATATTATAACACTGAC[A/C]GTCAAAAACATGGTTA rsl0788562 ATATTGATAAATGCTA[C/T]AGCACGCTTGAACCGC rsl344485 ATATTGGTGAATCACA[C/T]TGACACAGTCCCTAAC rsl428704 ATCACACTACTCAGAA[C/T]GGTGATGCACAATTTA rsll810706 ATCATTTTCTCTCTTC[A/G]CAGTCGCTTGGTTTGG rslO816423 ATCTGGCCTGAAGGAA[A/T]TCACTGTAGTGAGGAA rsl935733 ATTCTGTTAAATACTG [C/T] CAG ATTTA I I I I I I IA rsl371225 CAAATCAAGAAGACAA[A/G]TAGAATGATGATGGCC rsl434764 CAACAAAAAAGTGGAAIG/TJTAGCTTAAAGAAGTAT rsl91606 CACACAACAATTTAGA[C/T]GGATCTCAAGGGGATT rsl2973797 CACATGTGGGTCGTCAIA/GJCTGCCATCAGGAGTAG rsll243149 CACTGTCATGTCCATA[C/T] ACGTATACACACAGG A rslll83154 CATGTCCAAATGACTA[C/T]CTACAGTTCAAACTGC rsl0280940 CATTAGAAAGGCCCCC[C/T]GAAGAATCCCTGTGTC rsl2119983 CATTCCTGAATGTTTG [A/CJAAATAGAAGAGGCTTC rsll77257 AAAATCAAACAGGAGA[A/G]CAACGTTACACAGAAT rsl6988954 CCTTGCTGCTCAGGAA[C/T]AATCATTGGAACTCCA rsl7099248 ATAGTCATCG CTCTTC [A/C] CAAC ATTTCCGTGTG C rsl416078 CTAAGGCTTAGTTGGAIA/GITAAGAATAAGAAGGAA

rsl3121032 CTATTGATAATCCCCA[A/C]GCCTCATTTTAGACAC rs2014525 CTATTTTCTGGG ATTG [A/G]CAATAGTAAAAATG AC rsl2796585 CTCACAACTTTGGTAA[C/T]TGTTAATCAGTGGTAA rsl999717 CTCCCAGGCAACAGTG[C/T]AAATGGAATTGGAACA rsl6967971 CTTAATCATCCGGGAA[G/T]AAATAAATGTACCAAC rsl0166160 CTTCACGTGTCTCTAC[A/G]CTACTCTACGACATTT rslll46456 C I I I L I I I CCTGTGCA[A/G] ATTCTTG CG G GTCCCT rsl545653 GAAAGAGATTCGAAGA[A/T]CCTGCTGGCTTGAAGA rsl7692715 GACCTTTTCTGATCAA[A/G]CCCTGTGTATGGCTGA rsl0493750 CAAGGTCCTGAAAAGAIC/TJGGGAAATGATTAGAGA rsl0116752 GCAGTGAACTGGGGGA[C/T]GAGCCTGTCAACATTG rsl7233934 GCATCCTATGAGGATA[A/G]AAGACACAGAAGATAA rsl2471083 GCCTGTGACATTAGGA[C/T]GATTATTTTACCTTTC rsl0197623 GCTTGCAGTTTAAAM[A/T]TTTTGCTTTAGTGTAC rslO196764 GCTTGCTTCAGACATA[A/G]CCCTGAGAAATGGCCC rsl0892549 GGAGCTCTGTGCCATG[C/T]CAAAGGAGGAGACGAG rs32062 GTACTTCTCTCATAAA[C/G]CTATTGTGAGGATTAG rs4260776 TAACATCTTGGAATGA[C/G]AGGCCAACAATAGACA rs4580841 TAGGAGACTACCTAAA[A/G]TGATCTTCAGATTCCA rs2851911 AAATCCTTTCAAATGC[A/G]AAAGTTTTTCCAAACC rs6803927 AATGTAGGTCCATAAA[A/C]TGTTTGCATTGATCCA rs7019068 GGCAG ACATTTAATTG[C/G]ACAGCTTTGGTCAGAT rs6673397 GGCCTGTCAAATGCAA[A/G]TGCGTATGTGAATGTG rs2133774 GGCTGGGGCCAACAAA[C/G]GGCAAGCAGAAGTCAA rs363029 GGCTGTACATTTGCTC[G/T]ACTCACTTCAGATATC rs2090980 GGCTTAAGGTGTCATC[A/G]AGTGCCAAAAAGGAGA rs6508259 GGGATACAGCTCACAA[A/G]TCTATTCTTTAAACAA rs2413429 GGGATGAATGAGTTCAIA/GJAGTCTTGCAAAAGGGA rs7201164 GGGATGCGCATAATGA[C/T]ATAGTGATGAATTCAA rs538343 GGGATGTGGTACTGAGIA/GJCCAAGGAAGAACAGGA rs6012271 GGGATGTTCATCGCAG[A/G]AAGGAAATTACTGAGT rs2176775 GGGGAATCAAAGATaWC]AATCAGAGGGTGCTTT rs6944568 GGGTAGGGTAAAGACA[A/C]CTTCAGACTTGCTCCC rs2730306 GGGTCAGCGACACAGA[C/T]GGACTTCCGTGGCTAC rs4920708 GGTAAAAATCATATAT[A/G]AAATGGCCACAGTTAA rs2127546 GGTATACTGGTATGTA[C/T]GGCGTG AAG AAAAG AG rs2292927 GGTCATCGACCAGTACIA/GJGCATCCCACAGGTAAG rs341081 GGTCCAATTAGCATGA[C/T]GTCACCAATATAGTGG rs4673727 GGTCCAGCTTTATTTC[A/G]CACTAGGCTGTGAGGT rs497898 GGTCTGCCCAGGGAAAIA/GJAAAGACACTGAAGACC rs515603 GGTGCATTAACAGCTCIA/GICTGCAGATTTGCAACT rs4333309 GGTG I I I I I GTGAGAA[A/G]CCTTGTAGCTGTTACT rs3909441 GTAATGTGTCTGTTTA[C/G]ACCTTCTGCCCATTTT rs32062 GTACTTCTCTCATAAA[C/G]CTATTGTGAGGATTAG rs4412753 GTAG ATAG AAAAAGGG [G/T] AG ATATTGGTCAAAAT rs4905630 GTAGTGCATCTTGCTA[A/G]GGGTTTTATGATATTG rs644437 GTATGCAATGCCACAG [A/C] AATTTTAC AGTTC AG G

rs4947696 GTATTGTTTAACTTCC[A/G]AATCCTGAAGAATGGA rs6694745 GTCACTGTATGTTACA[C/T]TGCATTTTGTAGAATT rs2602707 GTCAGGGGTTCTCAAA[C/T]GGATTTCAGGACCCTT rs4538346 GTCATAAAAATTGTGA[C/T]GAACCACATGAGGAGC rs3846116 GTCCTACACTTAGGAA[C/G]AGGTACTACCAAATTC rs7188142 AAGAGCTGCCTCCTCA[C/T]AACAGGTCAAGTGCTA rs7146217 GTCTGGTTTTCTATGA[C/T]GGTAACTCAGCTGTAA rs2041909 GTCTTTTCACTAATCA[C/T]AAATAAAGCACGAAGA rs4381737 GTGAACTTGGAATTGC[A/G]ATAGCACTAATACAAC rs4688828 GTGACAAGTGCAGTGA[C/T]GAAAAATAAAGCTAGG rs2607073 GTGACTGGATAGGAGAIA/CIAGCCACAAAACGACAA rs6446391 GTGACTTAACGTAGTA[C/T]GAGAACTGTTGAGCTT rs7161611 GTGATCAAGGTTAACA[A/C]CACCAGTTATAAGTTA rs7130460 GTGATGAAACTCCACT[A/G]AGCAACAGAATAGGCC rs2419950 GTGATTCAAACGCTAA[G/T]GATACAGGAGCTAAAA rs2935624 GTGCAGAGCACCATGAIA/GJGATCAAACCTGCATTC rs708209 GTGCTTTAAG AACTCG [C/T]AGCTCTGGCCGGGCCA rs2723483 GTGGCTTAAACACCAA[A/C]CATCAGATTAATTCAT rs375973 GTGGTGGTACCTGGAA[G/T]TGGTGGTACTGACAGC rs2303788 CCCCAAATGTTTGCAT[A/C]ATAAACCCATTGCCTA rs7191101 GTTAATGAAAAGGAGA[C/G]AAAAACCAAGACACGG rs2263643 GTTACTTCCTACATAC[A/G]ATGGGGGCATAGGCAT rs7237496 GTTAGAGCACATTAAA[A/G]CAACTTTGGCTACTGT rs4608500 GTTCTC I I I I I GTCAC[C/T]CTATCTCAAGGGCTGG rs3867493 GTTCTTTGAAG CTTTC [C/T] ATTG GTTACAATTCCA rs7307697 GTTGAAAATGATGAAAtA/GlAAGGGAAGATTCTTAT rs6455209 GTTGAATTCCACTGAC[A/T]GGAAAGCATTAAGTAA rs6727239 GTTGCTC I I I I I AAAA[A/G]TCTCAACCAATACAGA rs2098242 GTTGGAGTAAAGTGAAIC/TJGAAATAATCAGAATGT rs259994 GTTGTCCAAGTGACCA[C/T]GGGTAGCCTCGATGCT rs6136503 GTTGTGTTTTTCCTTC[C/T]CCTTCCCTATAAGTCA rs4243177 GTTTAGAGGCGCCAGA[A/G]AAAGGGTGAACAGGGA rs4940259 GTTTCATGCCTCTTCAIA/TlTCTGATTTCCTTATAC rs28891 GTTTGTACTTCGGATA[C/T]AAATATGTGCATAAAA rs2077663 GTTTTATGTCAG ATTG [ A/C] ATGGTCAATTTTAG AA rs445511 GTTTTGGTAGAGCAAC[G/T]GATCCCTTCCATCCCC rs4384747 TAAAACACAAGGGAAA[C/G]GATAGATGACAATACC rs4367362 TAAAGGTAATATCTCC[A/G]GCATCGCCTTGATACC rs6693866 TAAAGTTTAGAAACAC[A/G]AAAACATTGACATAAT rs6861743 TAAATACAAAGGATTC[A/G]AAATTTACAGTTTACA rs2740485 TAAATGGTGCCTCTAAIA/CJATAAAGGGAAATAAAA rs6671391 TAAATGTAGTTCAAAT[C/T]ATACGTCTATCAAATT rs4260776 TAACATCTTGGAATGA[C/G]AGGCCAACAATAGACA rs353972 TAACTTACACTCATGA[A/C]ATCAGCTCAGGATTCA rs33962847 TAACTTGTCTTCACCA[A/T] CCTTC ACTAACCCC AA rs2147102 TAAGCAAAGCCAGGAT[A/C]ATCATTCTTATTCCAT rs2116682 TAAGCACTGCAATACC[A/G]CTACAGTCGATCTGAT

rs4339624 TAAGGAGCTTGTTGAA[A/G]ATCACrGAACTGGTGA rs4535211 TAAGGATGTCGTGTAAlA/GjCATATCATTAATGTAG rs4940275 TAATG ATGGGACTCAG [A/GJCATAAGG AAAAAGCAA rs2367291 TAATTATGAAAGTTTC[A/C]ATAGTGATTCCAGGCA rs7208976 TACrCTTATGAATCCT[A/G]AAGTTATCTTGAAAGG rs2447196 TACTGCrGGGTTTTAA[A/G]TCTTGCCTCTGCCCTT rs4861686 TAGACTCTCCATACCA[A/G]AAAAGGCCACAAGAAA rs2352603 TAGCAATTGGCTGAAC[A/G]ACTTATTTTAAGCTAG rs4387746 TAGCATAAATTGCCAC[A/G]CTACCAGCTAATTGAC rs4580841 TAGGAGACTACCTAAA[A/G]TGATCTTCAGATTCCA rs7136397 TAGGGAAGAAAGCCTA[CyT]GGTGGTTATGGAGGGA rs4643164 TAGGGACATCTGAGAA[A/C]CTACATTCACTGAGGT rs2217250 TAGTACCTCATTATAA[C/G]AGCCTGAACTAAGACA rs2623770 TAGTCAAGTCAATCAG [G/T]CCTACCATCTCCTATC rs6481864 TAGTCAG AAG AAGGGG [A/G] ATTTCCTG ACTATTCA rs4955205 TAGTC AG G CTCCCTTC [A/G] CTTTCC AG AAAC AAG C rs488615 TAGTCTCCTTTCCCCA[C/G]TCTTGCCACCCATTTT rs4702266 TAGTGAGGCTCACAGC[A/G]AGTTAGGTAGATGGGA rs4873692 TATAAGGCTACATCAA[A/C]GTATAGGACAAATTTG rs2934467 TATAGAATAACGCTGAfA/GlGAGCTGAAATGAATCT rs6444003 TATAGTTAAAGGTTAA[C/T]GGCAAATACTCATCTC rs6697315 TATATTTG AGTTCTAC[A/G] ATTCCCTGTTCACTCA rs268485 TATCACCAAGTTATTA[C/G]CAGTGCTTCAAAAAAT rs7199582 TATCCATCATTTTCCC[A/T]CAAGACTGACAGCTGA rs4756093 TATCCTCTAGAACTGC[A/G]AGGAAACAGATTTCTG rs6673013 TATCCTπTAACCTGC[A/G]CTTTAATAAATGTTAA rs6503352 TATCTATGCAGGCAAAIC/TITCTAGGCCCCAAGGCT rs35424097 TATGTCTTGCTCTTGA[C/T]CTAATGCTGAGGGAAA rs7246997 TATTACCCCAGGCGAA[C/T]AATGCCACTTCACTAA rs4795164 AGGTTGCCTTTGCATG[C/G]AGAACAGGGTACAAGA rs6978780 TATTGGACAATGCCAC[C/T]GAAGTAGTGAAAGAGA rs2596586 TATTGGTAGAAAAGTA[A/T]CTCAGCC I I I I I ATCT rs6673199 GCCACACCCTTAGCCA[A/G]TCTTGGGCTGGATTTC rs4971264 TATTTCCAAGTGCACA[G/T]ACATTGATGGGTTTGC rs355483 TATTTCTCTACTGTGC[C/T]GATACTGTGTCCACAC rs6788209 TATTTTACTCAGGATA[A/G]GAGAGTCAACATTGCA rs2225361 TATTTTCTATGTCAGA[A/C]ACTTCACATTTAAAAA rs2642849 TCAAAAATCAGTTGAC[C/G]CTATGTGTGGCTGTAT rs2840588 TCAACAATTTGCAGAC[G/T]CTTACAGTTCTCTCCA rs4128658 AGTGCCAGAATTAGAC[C/T]CTCTCCTCCAGACTAG rs2741311 TCAAGAAATTGACTAC[A/G]GCCAGGATCTCCCCAT rs6807126 TCAATAGTTCAAAACTIC/GJAATGCTACTAAAGGAT rs7317112 TCACATTGCACACTAAIC/TIGTAATCCGTCGGCAGC rs2654981 TCACATTTCAATGGTA[C/G]GAAAAGTGGCTTCGTA rs2710016 TCACCTAAGCCTCACA[C/T]TGAGAGAAGTTCTTCC rs2886927 TCACTCACTAGCCCAA[A/T]GTTTCTCTGTTGCTGC rs260005 TCAGCTTGACTAATTC[A/G]AAAATATTTACCATGT

rs6737578 TCAGTCACCCTATGGA[A/G]GTATCGTGTCTTGCCA rs2975272 TCATTTGGTGCCGACG[C/G]CCTAGAATCACACAGG rs7123164 TCATTTTCTGAAGGGA[A/G]GTTTCAGCTTTTATCA rs485056 TCCAAAAGTACTTTCG [G/T] ATTCCTGGCCTGTACA rs2804085 TCCAATπTGAGTGTA[A/T]GCAAATCTGTGTmT rs2277924 TCCCAAGCTTGCTCCC[A/T]CTCCTGTGCAGGCCAT rs3789052 TCCCCAATGGTTATCA[A/G]GTAGAGCACTCTCTAG rs729438 TCCCCCAGGAAGTGAC[A/G]ATCATTTGAATCCTGG rs6985315 TCCCTGGGCACAACCA[A/G]GTTAGACAAGCCAGAA rs2736172 TCCCTGTCTTTGGACA[C/T]GTAAGAATTGGAGGAA rs2631046 TCCTCATG AATGTGTA[C/T]G AAACTTGTG AATATC rs2699367 TCCTCTACCAAGCAAA[A/G]TGACTAATTAAGCTGG rs6445024 TCCTCTCACTTTTATA[C/T]AGCCATTGGTTGGGTT rs6701181 TCCTGTCTCAAAGAGG [C/T] AATATAGTGTGAATTG rs6019480 TCCTTCTAATAATATC[A/G]ACATACAGAAAGCTTT rs7220293 TCTACCAGGACCCAAC[A/C]ATAACGCTACTGGGGT rs2372558 TCTATTCAGTTAATGC[A/T]ACATTCAAAGGGATCA rs2269436 TCTCTCTTGTTGTTTA[C/T]AGTGTTTGTTGCTGTA rs2949644 TCTGG AAAAAAGG ATG [C/T] AACTCCAGTTCTGCCA rs4584771 TCTTAATCCTCTTGGC[A/G]AATAGATGAGGAGTCT rs4894760 TCTTCATAATGTCAAG [G/T]CCTAACCAAG AACGCT rs2139148 TCTTCCAGCTACTCTA[A/C]CTTCTTCCCAGCAGTT rs4118375 TCTTCCTCAACAGCCA[C/G]TGAATCAGTTCCATCC rs552643 TCTTTATGAAATTCAA[A/G]GTAGTCCAGTTTTCTT rs2468244 TGAAGGAGGGCTTTCCIA/GIAAGGAGTAAAGAATTA rs2169170 TGACCAAAATTTACCA[C/T]GATTTTCCTGATTCTG rs6711054 TGACTAAGGTAGTGGA[C/T]GAACAAATGTAAACAT rs7203172 TGAGAACTACCCAACT[A/G]AGCCAAAGTAACCCAC rs6033406 TGAGAGGGCTGATCTA[A/G]TAAGTTGAGCTCTTCT rs360087 TGAGCCCCTGCTAAGC[C/T]GATGAGGTAGGCAGTG rs4757710 TGAGGAGTATGATGGA[A/C]GATGCTCTAGAAATTC rs634585 TGAGTGAGTTACCATA[C/G]AACCTGAGCTGCCCAT rs2789416 TGAGTTAAGCACCTAA[A/C]AGGAGTTTGCTTCCAT rs4496808 TGAGTTACGCAAAAGGfG/TjATGTGAAACATAAATG rs2677810 TGATAGGGAGACCGACIA/GJGAGACAGGTGAAAGCA rs702605 TGATGAAGGAGAATTC[A/G]GAATAGGGAAATTTGT rs7236339 TGATGCCTGCACAGCA[C/T]GGCGGTTGGAATTCAT rs522740 TGATGGGCCTGAGATC[A/G]ACTTCAGTGATGGGGA rs443543 TGATTGACCATTCCCA[A/T]AATCCTACAGCCTTTA rs7072493 TGCACAGCCCACAATA[C/T]GAACTGTTTATAGATT rs7119964 TGCACTGCCAGTTGCA[C/T]AAAAGTATAGCACATA rs4925109 TGCCCTGGTTAGAGGA[A/G]GCTTGTGAGATGGAGG rs2474339 TGCGCCAGGGTTTGTA[C/T]GTCAAGTGTCAAACAT rs4811684 TGGAAAAAACAAGAGG[C/T]CACTTTTGAGCCAGGA rs4983073 TGGAAATAGCAGATAA[G/T]GCACCTTAATGCACCT rs7100934 TGGAGGGACCTCACAA[C/T]ATTTTGCTGAACGAAA rs292071 TGGCAATAATCAAAAAIA/GJTAGTAGGTGTTGGCAT

rs3112857 TGGGCTATGCCTAGAA[C/G]CTGTAGTTGATGATAA rs2353545 TGGGGAGAAGAAAGGC[AZG]CTTACAAGAAAACAGA rs2113545 TGGGTAAAGGGCTCTC[C/T]ATGCAGTAAATGGTAC rs4664865 TGGTCCCAGGGTATTA[GZT]GAGGCTCTCTGAAGTT rs221188 TGGTGTCTCTCTTAAA[C/G]GCAAGGCTTGTGTGTT rs2368053 TGTAGATCTTTTTCTG[A/G]AGCCTTAGTAAGTTTA rs4985702 TGTAGGTGTGAAGGGC[AZG]GAAGGATGGAGATGGT rs3737150 TGTCACGATTGCCTAC[A/G]GTACAGTATAAACTTC rs4514740 TGTCCATACTTGTGGA[A/C]G I I I I I I CTATTGAAG rs317326 TGTCTCATGTGAATCA[A/C]GACAGATACCAGTTAA rs6831405 TGTCTTTTCATGGCTC[A/G]CTAGTGCA I I I C I I I A rs7194394 TGTGCGCAGAAGCAGCIA/CJGATTAACGGAAGAACA rs4737886 TGTGCTTTCCAAAAGA[A/G]ATTTGTATGCACAGGC rs259991 TGTGGAACTGGACCCG[A/G]AGAGAACAGGAAGGAG rs7042894 TGTGGAGGCAAATACT[A/G]AAATTATCTGCTAGGA rs2911659 TGTGGCCGGCCTCTAC[GZT]GAAACCAGATGAATCT rs4720530 TGTGTAGCTG AGGTAG [A/G] AAG AGTGCCTG ATCCC rs215759 TGTGTATGTGTGTGTA[AZT]CCTGGTGAATAGATGT rs3768003 TGTGTCTAGATGAATA[C/T]GCACAAATTAAATGCC rs6948305 TGTGTGCTAAATTAGG [C/G] AAAAGTTAGTAAATAT rs6560309 TGTGTTTGGATTCACT[AZG]AGGAAAAGAGTAAAAG rs3956319 TGTTCAAGCCACTAAA[A/G]TTGTGGTAGCTTGTTG rs4635202 TGTTCTACATCCACCT[CZG]AAGTGTGCAGGCCTTT rs631408 TGTTTGTTGAATGGAC[AZG]CAAAATCTTATTTATA rs2960744 TGTTTTCATTATGCTA[A/T]GTACAAGATTGTGCTA rs6050167 TGTTTTGTAACAGACAIA/GIGGAAACTAGAGTATGG rs3917786 TGTTTTTGATCCACAA[CZT]GAGTTGAATCCGTAGA rs2481628 TTAAATAAGCCTTACA[CZT]AAAAAACTATCAACAA rs4940497 TTAAG AAAGCAAGTTG [AZC]AATGTATGACAAAAAT rs4239307 TTACATATCAGTTGCT[AZG]AGAATATCTTCTTCCA rs454356 TTACGGGATAACAACA[CZT]GCTCTCTCAACCCCGG rs2239578 TTACTAGATπTCAAC[AZG]CTCTAGCTTCAGCTTT rs2387573 TTAGAACACTGGCCCA[CZT]GTGGAGGACGTTTATC rs6472930 TTAGAGACTCAAGAGA[AZC]CTCGACAGTAATCAGA rs629222 TTAGCTCAGGTGTTAC[GZT]GACTTCTTTGAGGAGT rs6037908 TTATAATGGGGAAGAA[AZG]ATATATGTGGCATCAG rs452616 TTCACACTACTAGTCG [AZG]AATGTAAAGTGATGCA rs6751830 TTC ACATATTTTCCC A [AZC]ACTTCATCTATTCCTA rs4369676 TTCAGAGTGATTGTAA[AZG]AGGCCTGCATGATGCA rs2185938 TTCATACACTGTTCCC[CZT]CACCTGGACAATTCTT rs7082705 TTCATATACCACAAAA[CZT]CAGTCACTTGCAATGA rs6564988 TTCATGGTCAGCCAAA[AZG]ATTCAAGGGAACCCAG rs2532660 TTCATTCACTCAGCCA[AZG]GAGATATTTCTGGAGC rs507529 TTCATTTAATGGAATC[AZG]GATGTCACAAAAATAC rs2962394 TTCCTCCTAGGAGTGA[CZG]AGTGAAATAATCTGAA rs716553 TTCCTGTCTGTGATCA[AZG]TGAAAGGCATCTTCTA rs7238071 TTCCTGTTGAGGGCAA[CZT]GGAAGAATTTGGCAAA

rs3753305 TTCGTTCCTCTGGTAG[C/G] AATTGTTG AGTCAAAA rs2896769 CTGTGAACAACCAACA[C/T]GGAAAGCATTAAGAAA rs2587163 TTCTCTACTGCCATGA[C/G]GGATCTAACAGCACTC rs574776 TTCTCTCCTTTCCAAA[A/C]TGAGTCATGGAATAAC rs6018685 TTCTCTTGCAAGCAAC[A/G]GAAAAAGAGAAGAAAA rs2874710 TTCTGCAGGAAGAGAG[A/G]AGAGGGGTTTGGCCCT rs2406198 AG ATGCTG AAGGAGAG [A/G]CCCAGAGTTCACAGTC rs3117598 TTCTTAGCTTTGACGA[A/C]TATACCATGATATTGT rs6921316 TTCTTCACTTAACATC fC/T] ACATG ACTTTCCATCT rs286216 TTGAAAGTTTGCTAGA[C/G]AAAGAAAG I I I I I I CA rs6780822 TTGACAGTTTTCCAAG [A/C] AGAATTAAGGTTTCCA rs4790200 TTGACATATGCACAGA[G/T]GATCTCTTTTGATTCT rs651009 TTGACTTAATGTGAAAIA/GJAATACATACAGGAGAA rs2930040 TTGAGAATTATTCACA[A/T]CCCAGCTGATCCTTGG rs7071067 TTGAGCCAGCTGTTAC[C/T]AGAAGTTGTCCATTGA rs3113484 TTGATAGTAATTTGTA[A/T]CACAGTGCTGTGGCTG rs4775698 TTGCACAATGTAAACC[A/C]CAGGACTTATGGAGAA rs42814 TTGCGGGTTCAGTGAA[C/G]AGGTAGATTCTTGGAC rs2539831 TTGCTATACCCTCAAC[C/T]AAGCTCTGCATTTAAA rs4883520 TTG CTGAGTAAG CAAA [C/T] ATAGCA I I I I I CTTCA rs4941199 TTGGACCTTGAATTGC[C/T]CTTAAATCACACATGC rs7191770 TTGTTTGGTTAGGTGGtA/TjATAGGCAATATTCTGA rs2367289 TTTAAAATCTTGCCCC[A/T]ACATTAGATTACTTAG rs7035425 TTTACTGTGCACTGAA[A/C]AGGTCTCTATATTTTG rs6980348 TTTAGGCAAATAG AGG [G/T] AAAGCAG AG AACTTTC rs2158951 TTTATG G GTATTACCA [C/T] G ATTTATTTTCCATTA rs260011 TTTATGTGL I I I I I GG [A/G]CATTTGG AGAAAAAAA rs226389 TTTCAGAACGATAGAC[A/G]CTGAGCCATCTAAAGC rs4279411 TTTG AAAACTG ATCAC[A/G] AGTAAG AGATTTTAGT rs2318149 TTTGCAGCTACATACA[C/T]AGGGTCAGAGAATGTT rs2912020 TTTGCTAAAAGTCTTC[A/G]AAAGATTTGCCAAGTT rs2617191 TTTGTTCTAAATGTCA[A/G]CTTGGCTTGGTGGTTG rs4691961 TTTTCTTGGAAGTATC[A/G]ATAAATGTGTATGTAA rs2194325 TTTTG AAAACATTAAG [C/T]CCCAATAAGCCTTTTG rs4333195 TπTGATTACTGACTC[A/C]ACTGCTTTTCTTATTG rs4951276 TTTTGATTTTCTTCTG [A/T]CAAAGACCACAGCAGT rs6590229 TTTTGTCAACCTGTTC[C/T]AAGAAAATAATCCTAA rs217537 TTTTTAAATAATGACA[C/G]AGATGCCCAAAAGAAA rs2278860 TTTTTGTG ATAATCAG [C/T] CC AAACTATG ACAACT rs2391782 TTTπGTTTAGAAACC[A/G]GAATGTTGGAGATTAA rs2194390 AGCAATAATAAAGATGIA/GJAGAGTATCAGCTAAGA rs2194391 AGCAGCTTAAGATCCA[A/G]TCAAAAAGACAAAATA rs6713 CCCTGGGTCAGCGCCA[A/G]AAGAAAACCTGGAGGG rs4586627 CTTTCTTGAAACTGAC[A/G]GCAACTCCAACAGCTC rs3790990 CTGCTGAGTCATCAAA[A/C]GAAAACACTCACTCAA rs2789417 TCACGGTAGACACATA[G/T]ATTGTACTGCTGCATG rs2837366 AGATGCTTCTGTTTCC[A/G]GAGCCGAAAGTATAAG

rs2839580 TTGCATCTTTGGGTTA[A/C]GGCTCTGCTGCCCTTG rs2157329 TGTTCCTTTAACCCCC[C/T]GATTGCACCCTGAATC rs2205895 ATCTCTAACTGGTGAT[A/G]AAGCATCATGAAATTC rs6808207 CCATGCGTTCTrAATA[C/T]GCTTTCAAAGATTTCT rs4955814 AAGGCAGTGAACTAGT[A/G]ACAAATAGGATGACTT rs2885865 TTATTCTG CCTTTATC [C/T] AG I I I I I C I I C I I GGT rs704829 CAGGGCACAAGCTGGA[C/G]GCAGCAAATGGGCAAA rs2317750 GGCACTATGACTAAAA[A/C]AATGCACATCCCCTAA rs2317703 TGTTATTGATGTGTAGIA/GJAATTCTTTGTATAATA rs355460 TATATGTGAAATACCC[A/G]AACTTGGAATGCATTT rs6814897 CAAATAATGCTTGGAA[A/G]TGTGCTTTAGTTTTCT rs2101210 TGCACAGATTGTTTCA[C/T]GCTTTGAGTCACATAA rs688808 TATGTGCTGAGTCATA[C/T]GTAGAGTGCTAATTAT rs4600972 TGAAGAGGAGAAAAAC[A/G]CTACATAACGTGCTAA rs6839406 TGCTGAATATCTCTGT[A/G]AAGCCTTGCTATATAT rs6427833 CTCACAGCTGTAATAA[C/T]TGAGCTTCAGATTTGC rs4861945 TGTTATTAGCTGTAGA[A/G]CCAACCACTGTATGAT rs347559 TTGCTCAATCCCTGTC[C/T]CAGATTTTCATGAGCA rs2706364 CAAATATTACTGTTTG [C/TJATCCAACAAG AG AAAA rs34170515 TCCAAATCAAGATTCC[C/T]CAGACATAGCTTCATA rs610414 ATTAATGGACTTCAGT[A/T]ACCAGACCCTGGTTCC rs4132236 TCTGCCATTGGCACTG[A/G]CAAAACCTCCCAAACA rs3762404 TCAACTAAAAATCTCT[A/G]ACTTCCGTCTTCCCTA rs2146162 TAACTTCCTCTTTCAA[C/T]TTACCATGTAATTCCT rs34247980 ACAAGCCAGGCCAGCT[A/G]ACTATAGCACAGAATG rs4128841 GGATCCCATGTGGAAT[A/G]AACCATGTTACCAGGA rs2241152 AACATTTAAGGGCAGGtA/GlAAAGCTAATAGTAATT rs2248922 CCAGCTCTGAAAAGTT[C/T]AAAATTTTGCTACACC rs42511 TTACCTGGTAATCTCA[A/G]TGAAGAGAGAACTAAC rs2110379 AAAGACTTACAAACAA[A/G]TGCTTATAGAGCCTTT rs2350786 CATGGAGGCAAACTAC[A/G]GTAGCTGATTACCATT rs2738079 TTCTGTTCCACAAGCT[A/C]AGAGGAAGCAGAATTT rs3912537 ACTGCAGGTC I I I I I A[C/G]CTACTACAAGAGTTTG rs2203661 GAGACTTTGGAGTGTGIG/ηACTGTTCGGTTAATAT rs4394376 ATCCTCCATCCTTGAC[C/T]ATTTCAGATACAGTCA rs6472334 TCTAACCAAATCACCA[A/G]TCAAAGGTGAGGGCAA rs4131931 TCCCACCCACCTACAT[A/C]AGACATTGAGGATGCC rs2173577 TATAACTGTTATATGC[A/C]CTGGAAACATTTAAAA rs6996243 GTTCCTCACAAAACTA[C/T]CTTTGCTCTATTGAAG rs719213 GCAACAGCAATATCCT[C/G]TTTCAGAACTAGCGCT rs2991304 AAACTTGACTTGTAAA[C/T]CTAAGGAAGGATCAAG rs725961 TGATAATAACCATAAC[A/G]TCTACGAACAGGTGAA rs2251760 TCACTTGGACACTCAA[C/T]CTGAAGCAGAGAATCC rs4279792 GCCAAACTCACAAAGA[C/G]CTTGAAAGTCTCTCTC rs7094917 TTGGCCCCCCAGTTCA[C/T]AGACAGTGACTGCTCA rs2812657 CTCATCTCTCTCTTTC[C/T]ACAATCCCTAGACTGT rs4378283 ATTCATTATTGCCAAA[A/G]ATTTCTAGAGGACATG

rs2282367 GCTATCGTGCTAGGAC[A/G]AGAATCCACCCCTCAG rs6492734 AGAGTGTGCTCAAGTG[A/T] AATCG ACAACCAGTAA rs4771651 TGGCGGGCAACTGGGA[C/T]GAGCAAGTTTCTTTGC rs4420537 GTTTTACTGAAGAAGA[C/T]GACGGATTGAATTGAC rs6499142 MTTCTAACTGCCTCC[G/T]GAAGGTCTCACTCCAA rs7193614 TAGTTTTGTTCAGGAC[C/G]ACAGACTGAGAACTAC rs4497678 AAACAAAAATAAGCGG[C/G]CCCCATCTTAAATCTT rs4789193 αCCCTAGGACTCTCG[A/T]CAAATAACCAGGAAAT rs438163 AAACACCCAGAGGGAT[C/T]ATAGAGCCAGGCAGTA rs279259 TATAATCGAAGCCACAIC/GJGAGTCTCGGCAAAACA rs2255590 ACATTTATTGGTCTAGlC/TlAGCCAAGAGGAGCAGT rs6578592 CAAGGATGGTTCTTAA[G/T]GAAGGGAAAGTGTTCC rs2327267 TATAGCTGAGAAAACCfA/GlAGGTACAATGAGGTTA rs6041325 ACAGGCCTTTTGAATC[A/C]ACTACTCATATCAATG rs2242722 GGATTTCAGAGGGTCA[C/T]GATGGTGCCAGGCTAT rs3732979 TCTTTAGTATTTTCCA[C/G]TAGCCAGGGAGGCTGA rs2932966 GAATCTCACTCATAAA[A/C]ATCACCTCTGAAAATC rs4864949 ^" nTAAGTGTTGATTGT[A/G]AAACAAGACAGATTGG rs706679 TTACTTCCCAAATCCA[A/G]TCTTTCCAGCTGGGTC rs6665839 CCTCCTCAAACCTACA[C/T]CACAAGTTACAGGCAA rs6570848 CGACATTTTTAAAAGC[A/T]CATTAGAGTTGACATA rs2137997 TAATACATGATTTGGA[C/T]TCAATACAAAGGATAA rs4726116 AAGCACCAGGTTACAC[A/G]AATTGCCTGAATTTTC rs3922038 TGGCCCCTTTGTACCA[C/T]ATTATGCTGCTGCACT rs4572098 CTGTCGTGTTTAGGAA[C/T]GTCCACCTATTACTGT rs3008720 GCACCTTCTCCATGAG [C/T]CATTAAAGAGGCTTCT rs6477872 ACTTTGCATCTGTAAC[C/T]AACTGTGATCCTCATT rs2825233 ACACTGGTTCTGAAGC[A/G]AATGAGCTCTAGGTAT rs2826681 AAAAATTGTTATGACA[G/T]CATTTGACTTCTAGTT rs2186975 GCATGGTGTCTGCAAC[A/C]GGAAGGATTTCATTGC rs2826683 AAAAAAATGAAGTGAC[A/G]ACTGCTTTCAAAAGAT rs2826686 GAAGGTGGAAGAAAAAIC/TJGTCCTTACTAGTATGC rs7281608 GAGGTTTATACCTTGAtC/ηGTAGAGTGTGGAATAA rs2829276 AAACTTG I I I I L I I I C[A/G]CTTTCTCCGGCTTTAT rs2829583 CATAATTAACAGAAAC[C/T]AGTATGGATCTTGTAT rs2829585 TATTCTATAAAGGTTA[C/T]GCAGGTAGAAACAAGA rs222931 ATCTTCCAATTCATTA[A/C]ATCTCTCTACAGATCT rs468969 AGTATGTACACCATTA[A/G]GTACTTTGCTGTCTTC rs468522 ATTGACCACACCCTCA[C/T]CCCAAGTCAAATCACT rs2831491 AATGACCACAATAACA[C/T]TAACTTGAAGTGGATG rs2831543 AAGCATGAATAAAAGCIA/GJATGTCTAACAAATGTC rs2284512 GCAGTCTCAGCCTTCA[C/T]GTCTTTAAAACTAACA rs2833995 TATTAGTCAGGGTAAA[C/T]TACACAAGCTGCAGTA rs460976 ATGCAGCCAGGAAGGA[A/G]GCTATACCTTGCGAAG rs456016 ACATATCTCCAGGTGA[C/T]CAAGACGGGAAAGACA rs2838873 ACGACACATGTTTAAA[C/T]GGCATTCTGTGAGCCC rs4277507 AAAAAAAACCGAAAAAIC/GITGATCATTATCATATG

rs4571397 AAAAAAATTCAG CACC [G/T] G G AAATC AACATTTTG rs2396328 AAAAACAGTCTTAAGA[A/G]GCGTAGTAAACAACAG rs2057028 AAAAAGAATTCACCCA[AZC]GCTTACATAGCTAGTA rs2841941 AAAAAGCAGTCTCTCA[A/G]ACAAATTGTATTAGGA rs7073811 AAAACAGAGGACACCT[A/T]AAAATGATAAGGCCAT rs2926862 AAAAGTTTATTAAATA[A/C]GTACACAGAGGCCATA rs6831793 AAAATCCTGGATAATC[A/T]CTGATGACTCTGAACA rs2962615 AAAATTATCTCTAAAA[GZT]GCAAGTTAGATGGTGC rs354369 AAAATTG AAG CG ATAA [A/T] AG GTTAG CCTG G ATTT rs7207189 AAACACATTCAGGAAA[A/G]TCACAGTATACAAAAT rs6127813 AAACATAGCTTGATTC[A/G]ACAAATACCTACCGAG rs245820 AAACCTCATGCCATCC[C/T]ATTTAGACTAATTTTA rs622917 AAACGGCATTACACTC[C/T]AGACCTGGAGGCTTGA rs6771260 AAACTCTTGAATAGTA[GZT]GTTTTGACTGCTACAG rs4269885 AAACTTCACATCATTA[A/G]AAACATTCGGCTGAGT rs2227127 AAAGACATGAAAGGAA[A/G]TGTAGTTTGGTTTGAT rs5009801 AAAGCAATGAAACTGA[AZG]TAAGTCAATTCTAGAA rs6106974 AAAGTTGAGTTCTCTG[C/T]AAGGTTAGATGACTGG rs731017 AAATAAATTG AATTGG [C/T]CAGTCTAGCTTGCAAA rs3852539 AAATAGTCCTTAGGCT[CZT]AAAAGTGGTATATGTT rs2851911 AAATCCTTTCAAATGC[A/G]AAAGTTTTTCCAAACC rs7195806 AAATGGCCCAGGCTGC[AZC]AAAAAGGGGAGCAGCA rs6717050 AAATGTAAGTTTGGAAμ/GlGAAAGATAATTGACTT rs7248526 AAATTCAAATTTACTA[CZT]GAAATGTCGATAGAGT rs2283092 AACAAAACATTCATCA[CZT]TCAGTATCCCCTTGTT rs225549 AACAGTAATAGAACAA[AZG]TAAGAAGGTGGTTACA rs2267889 AACATACAGACTGAAA[AZC]TATATCTGCATATTGT rs3909788 AACATCCAACAACAAA[GZT]ATCCAATTAAATAAAG rs2712875 AACATCTCATAAATAC[AZG]CAGAAATACAGAAAGT rs6600358 AACATTGCAGGAAAGA[AZC]ATTTGTTTAACCTTGT rs303765 AACCAAGAAGCACTCA[AZG]TACATGCTCCATACAT rs2621459 AACCACCATCATCTCA[CZG]TATCTCTTGTCTTGTA rs7228465 AACCTTGTCCTGTGAA[CZT]GGAAATGAAAGTTCTA rs3181 AACCTTTGTATGAGCC[CZT]ATTAGCTGCCTCAGCT rs6497089 AACTATTACTACATAC[AZG]GCAACCACTGGGAAGG rs6472345 AACTTTTACAGACAAC[AZG]CAAGAACACGCTAAAA rs615847 AAGAATGATTGTCTCC[CZT]CAGAATCCACACGAGC rs4141410 AAG AATTATATCATTG [AZG]ATTATTACTGAGCAGA rs341395 AAGACAGCAGCCAAAT[GZT]ATGTTATTCTGAAGTG rs2296580 AAGAGGAGAACTTCAA[GZT]TCAATTCTCAGGGTGC rs6666581 AAGCACCATATTTGTC[CZT]AGAAAAACCACCTCTC rs4789189 AAGCCAGAGACCTTAA[CZG]TAGTATTTTCAGTCTC rs6478519 AAGCCCTTACTTCAGA[CZT]AGTTATTGTGCAGATG rs6546626 AAGCTCTGAAATGAGA[CZT]GGTTTGGCTAGTTGGG rs6851194 AAGCTGCTGTCCAAAG[AZG]CGGAATGTATTCTCTC rs28890483 AAGCTTATAGATGAAC[CZT]AGTGATATGTGCATAA rs4631962 AAGCTTATTCCTACAA[CZT]TCAAACAGAGCCCCCA

rs7183000 AAGGACGTTTATCCAC[A/G]CTGTAGTGCTGCTTCT rs4761756 AAGG ACTTCATACGTG [A/C] AATGCTCCCCCTTTTC rs360973 AAGGCAGAATTTCAGA[C/T]GGATGAACTAGTGAAG rs2383957 AAGGG ATGTCATCATG [A/T] AACATAAATAAAGTTG rs2698119 AAGGGGAGATAGACAA[A/C]ATAAACCTGCAAGTCA rs3801929 AAGTAGATATGCACTC[C/T]ACTGGAAAAACATCAC rs3844157 AAGTATGGTCTGCAGA[C/T]GAACAATATGAGCCTG rs574695 AAGTTAGCCTAAAACAIC/GIAAATTCAGGCCATGAT rs4412353 AAGTTTTCATTAAACA[A/G]TCTTTCCAGTGGAGAA rs3762503 AATAAGGTAAAATTCAIA/GIATAAGCTTGCAGTTAA rs2709422 AATAATTCAACTGGGA[C/T]GGCAGATTAGAAATTT rs687188 AATAATTGTAATGATC[A/G]ATCAATCCAGAACTTT rs6050170 AATACCAATAACAGCC[C/T]ACTTCATTAGATTCTC rs221182 AATACGAAACATTATC[A/G]AGGCTCCC I I I I I I IA rs2604628 AATATAATGTAAGTAAfC/TjTGATGGTGGCTTTGGT rs6052724 AATATCCAAGACAATT[A/T]AAAAAAGTCCTCCAAG rs6878137 AATATGTGAACTAATAIA/GJGCATAAGCAGAATGGG rs2193374 AATCCTG CCAAAAAAA [A/C] C AATTGTG AGCATGTC rs2220521 AATCTCAGATCATTTA[A/C]CTACATCAAACATCTC rs731729 AATGGATGTTTTCTTA[C/T]AGGAAGCGGATGAACA rs7047479 AATGGCATTACACAGC[A/G]CACTATTACGGCAGGT rs6750269 AATGTAGAGCCTGAGA[A/G]CCTAAGGAAGTATCTG rs6803927 AATGTAGGTCCATAAA[A/C]TGTTTGCATTGATCCA rs2445859 AATTATAGCAGACATC[A/G]CTTTCAATTTGCTCCA rs4936235 AATTCACATAGAAAAA[C/T]GAGCAAGTAAGAATTG rs7027322 AATTCAGTTGTGTGAA[C/T]AGAACACAGTTTGTGT rs7123971 AATTCTTTTGGCAATA[C/T]ATCTAGAAATGGAGTT rs512421 AATTGAGAGGTGGATA[C/T]CTGAGGACAAGGAAAC rs344708 AATTTTCTCACCTTAG [A/G] AGTTAATTTTGTTTCA rs2873929 ACAAAAAACTAAAATA[C/G]AGTCCATTTGGTCCAG rs7067971 ACAACTTGGTTGTCAG [A/G] AG ATTGTGG ATAGCAC rs6432155 ACAAGGCAAATGTTCA[C/T]GGACTGATGGAAGGTT rs4663113 ACAAGTCAGAACCAGC[C/T]GAAGGGAAAGATGCAT rs4235846 ACAAGTGTAACAGAAAtA/TJGGAATGACAGAAAAAA rs6761875 ACAATACCAGAGAGGA[C/T]AGCACTACACAGAGAA rs597530 ACAATAGCTGAGAGAA[A/G]TATACCTACAATTATT rs6909531 ACAATCATTCAGACCA[C/T]TGGGCCTTGGCTAAGA rs2273120 ACACAATTGCCTTTAG[A/G]AAAGAATGATCAGTGC rs3858038 ACACATCCTCTACAGA[A/C]GCTAAAACCAAAGATA rs4290350 ACACTGATTCTGCAGA[G/T]AGTTGGCAATTTCTTC rs6913865 ACACTGTCTTGTGGTA[A/T]GTGCCTTAAGATTGAA rs635409 ACAGATTGGTAGGCAT[A/G]ATAACTTGCATTTCTA rs6050164 ACAGCATTCCTGGGCC[C/T]AGTCAAGACAGGATTC rs6955265 ACAGGATCTAGTGCTC[A/G]ATTGCAAGCAGGTGAC rs6825958 ACATTTAGATTGmC[A/G]AAMGTTTACTATTTT rs299900 ACATTTAGGTATAAAC[G/T]CAAAGTCATTTCAACC rs3863992 ACCAAGCCATTTATAA[A/G]GAAATCACCTCCATGA

rs257778 ACCACTCTGTGAGCTA[C/T]6TCCTATGGAACAAGA rs4258086 ACCTCTCACCTCAGCA[A/G]ATTCTTCAGTAATAAT rs6736617 ACCTGAGATTTTCAAA[A/G]GATGGATAGAAATTCA rs4543225 ACCTTCCTGATCCCCA[A/G]TAGACATCAAAATCAT rs673O55O ACCTTGTTTTAAATG G [C/T] CAAATG GTATCCTACT rs2090018 ACCTπTGGCTATCGC[A/G]AATTATGCTGCTACGA rs7302315 AGCTCTGCAGACCTGA[C/T]AGATGTGGCAAATACA rs4643103 ACGTCCAGCCTAAACA[A/C]GTAAGTTACAAATAAA rs2471533 TGATGAGGAAGATGAAIA/CIAAATCAGGAGCTTGTT rs421853 ACTCAAAG AAG AGTG A[C/T]GAAAATTAAGTTCTGG rs586124 ACTCCATTTATCCAAC[C/T]CCAGCAGTATCACTGA rs4663165 ACTCCTGCCTTCTTAT[C/G]AAAGCTGCAGGCCTTG rs4323877 ACTCGACAAATGCTTA[C/G]GAAGCTTTGACTGTGT rs3024676 ACTGAACCCTGACCAA[A/C]CTTTGCTTTTGCAGAC rs3911701 ACTGACCCATATTTAA[A/G]GAGTCAATCTTGCTAA rs595255 ACTGAGACAGAATGCA[A/G]GTATTAGCAAGGGGAC rs2553954 ACTTAAGAGCTCTAAA[C/G]TGAAAAACCTGGATTG rs709934 ACTTAGTGTGGTCGCC[A/G]AAGATAAATCCACCCC rs6590788 ACTTCTGCACCAGGAC[A/G]CTGGAGTCTGCCGTCC rs4656799 ACTTG AATTTTATCAG [C/T] AAGG ATCCGG ACAGGT rs3111694 AGAAAGAGGATGTTAAIC/TIGGAAAAACTGGCAAAA rs7193007 AGAATCTTTCTTGCTC[A/G]ATGTCTTCTCACTGTC rs644798 AGAATGGCTAGATCCA[A/C]ATAGTCTATCTGGGCC rs3919653 AGACAAAAGTGATAAA[C/G]TTGATTCATGCTTGGA rs3100734 AGACACACTTCTCCTA[G/T]CTTTGAGGATAAAGAC rs4569824 AGACATATTGGGCTGA[A/T]ATATTATAACTCTAGG rs2348914 AGACTATGAATTCCTA[C/T]ATCTGCCACCTGCAAG rs4716619 AGACTCTTTTTCCACG [A/G]AACATCTTACAGGCTA rs2988011 AGAGAATCACTTGTAC[A/G]AACTTTTCTCATTCTC rs431966 AGAGAGGAATTGAAAA[C/G]GCTGTCAGCTTTTATA rs298184 AGAGGGCTAGTATGCA[A/G]TGACTTCTTATTGAAA rs4789188 AGATAATGGTTGTAAA[A/C]TGCTTGGCAGAAGTCT rs6472931 AG ATACTTACAAATTA[C/G] ATTAGTG CCTACTG CA rs2343508 AGATACTTGGGGCTCC[A/G]ATTCTAAGAGAACCTG rs6997147 AGATATAGATGGTAAC[A/G]ATGTTTGCACAACATG rs2062099 AGATTTGAGCCTACGA[C/G]GTATTTTGTπTCACC rs6095314 AGCAAATGTAAAGTGTtC/ηAAGGAGATAATGTGAA rs379060 AGCAAGAAAGTCCTCG[C/T]CAGATGCCGGCACCAT rs6728947 AGCACCTCTATCAGTA[C/G]AACAGCGTTTCTCCAC rs2936535 AGCACTTTGCTCTTCC[G/T]CACCAATGCAGTACAG rs7203404 AGCAGAAAACAGCCCA[C/G]GTGTCATTAATAGTAG rs2412511 AGCAGAGAAAGGTATAtC/TJGTATGTCAAAGGAAAT rs6501786 AGCATTATCTATGGCA[A/T]CCTAAGATTTTTATTT rs7199114 AGCCAATTCAAAGAGA[A/T]TCCCTCACATGGCTGT rs4610242 AGCCTTCAAG ATTCGG [A/G]ACACAATAAGG ATGCC rs2846072 AGCTACTGACTCATTC[A/G]CCTTCCCCCAGCCAAG rs279257 AGCTGCAGGTTTTACA[C/T]GACTGTGGTGGATCCA

rs6657063 AGGAAAGATGGAACCAtC/GjTAGAATGCAAGAAGAA rs4406411 AGGAAATATTTGAGGAtA/GlGTTTGAATATAGCCCT rs6582 AGGAACAAATGAGAGA[A/G]AGAAGCCCAGCCTCTC rs3852016 AGGAAGTTCAGGTGCC[A/C]ACTGAGAAATCCAGAT rs6774426 AGGACTTGCATGAATA[C/T]GAAATAAATTTGTACT rs2620772 AGGAGGGCCGAAGGAC[A/G]CAAATTTTATTCAGTT rs7190186 AGGATCTGCTTCACCC[A/G]AAACTAAAGGTACATT rs4331429 AGGCAAAAGAGATAGCIA/GJAGAGCGGTGGGGGGTT rs32058 AGGCCATTCTTAGCAA[A/G]AGATGAATATCATGTG rs558930 AGGCTGCAGAGAGATA[C/T]GAAGAGTTTTACATTG rs2592115 AGGCTGGCGCCTCTTC[C/T]ACCACAAGGGAGGCTG rs4341081 AGGCTGGGG ACTAGTG [C/G]ATCATCGCTTAGG ATT rs2566349 AGGCTGTGGTCACTAA[A/T]CTGTAATGCATCTTTA rs6658141 AGGGATCTTGGACGTAIC/GJATAGGTATAAGCAAAG rs6589065 AGGGCTGATTATGTTC[C/T]ACCAAGTCACTATGGA rs461447 AGGGTGATTGGCATAAIA/GIGATAAATTTTTGATAA rs340260 AGGTAAGGG AGTTCAG [A/G]ACAAGGCCATTCATG A rs6736153 AGGTAGGGAGGAAGGA[A/G]CAGTAGCAGAATCTCC rs344701 AGGTGGAAGAGAAAACtC/TjGTATCATGATTGTGAG rs4712300 AGTAAATGAACTAATCfC/TJATAAGTGTGGTTATGG rs3776338 AGTATTAGACTATAGC[A/G]GACTCAAATTCTTAGC rs6669798 AGTCTATACAAGCTCA[C/T]TAATCCATACCTCAAC rs243839 AGTCTGAGTTTAATCA[C/T]CCTGCAATACTGTCCT rs4385034 AGTGAGTCACTCAGGA[C/T]CTTGATATTG I I I I I I rs245578 AGTTGTGCCAATAAGA[A/G]AAGACTACCTGGGACT rs6479616 ATAAAATGACACTAAC[C/T]GAAGTTTTACACAAAG rs6659552 ATAAACATAGCTCCTA[C/G]CCTCGAAGAGCCTCCG rs2383958 ATAAATAAAGTTGGAGIC/TJATAAGGCAGTGTAGTC rs3743034 ATAAGGTACTGGAAAC[C/T]GAGGAATTGCTTTACT rs304209 ATAATAACAAGAGATC[AZG]ACACTAGAAAAGACAG rs31899 ATACAAGCCATCGATA[A/C]ATTGCTCTAACAAGCC rs7185053 ATACAGTACACATTAC[A/C]ATTTGCGTCTAATGCC rs715975 ATACATATTTTAGCAG [G/T] AGATG AGTATCCCTTA rs3108049 ATAGAAAACTTTGACA[A/G]GTGATAGGTATCGTCT rs7243021 ATATTTCAGCTCCACA[A/G]TG AAATCATTTTATCC rs281302 ATCAAAAGAGAGTGGqA/GjAATTAGTTGGGGAGAA rs6675190 ATCAGAGTTCAAAGTC[A/G]AAAGCTTCCCAAGAAC rs3781349 ATCTCAGTGTTGTTAC[C/G]AGGATTAGAGGAGCTA rs2420378 ATCTG ATGTATCCTAG [ A/T] ACTCTGCAAAACACCA rs7197544 ATCTTAACGAATCTTG[A/C]AACAGCTCTAGATAAG rs251300 ATGAAGCTCTAGATTA[C/G]ATATCACAAAACACAA rs2844032 ATGAGACTGATGAGCT[A/G]ACAAAAGTAGGCTTCA rs4558955 ATGAGTAAGTCTACAG [A/G] AATAATGTCATAATG A rs6886792 ATGATTTGATAGAAAA[C/G]ACAAAACCATAGGAGA rs2396319 ATGCAAGTATTCAAAC[C/T]CAGCCAATTGTATACA rs6891838 ATGCCATCTTATCTGA[A/C]AGCACTTCCCTGACCC rs4905628 ATGGAATGGGACCAAAfA/TJTATAACAGAAAGCAGT

rs318860 ATGTAAGTGTGAAATA[C/T]GL I I L I I I GGAAGGAA rs2324872 ATGCAAATGGATCCAA[C/T]ACTTGGTTAGCCAATA rs7135433 ATGTCAGCTGCCATCA[C/T]TCCTTATGGAAAACCC rs7119426 ATGTCCCTGAAATCCC[A/G]CTACTTCAGACCTGAA rs2900601 ATGTCCTAAGAACTTA[A/G]TAAGCCTTTGTTCAAG rs7251213 ATGTCTCTGAATCTTC[A/G]ACAACACTCGTTAATT rs6095325 ATGTGAAACTGAAGCAIG/TJAGGAAAATACTTACAT rs2914591 ATGTTAAATGGACAAA[A/G]GAGTACAAGCTTCCCA rs619037 ATGTTGCAGTAGGAAT[A/G]ACCTTGAATCTTATGT rs2127547 ATGTTGGCAAAACAAA[C/T]ATCTCTGAGATGCAGT rs4909954 ATGTTTAI I I I I CAAC[C/T]GATGTCATG I I I I I CA rs3856447 ATTACTCTAACTCAAA[A/G]TACTTGCACAGCACCT rs2743979 ATTAGTATACAGTGGC[A/G]ATTAACAGAAGCAGAA rs620095 ATTATATCCTGTACAT[G/T]ACTTCAAAACTGTGAT rs2895598 ATTCCTCTCTTATGTC[G/T]AGATTCCACTTTCATT rs4741833 ATTCCTGGTACTGGTA[A/G]GCTAAACCATGTTTTG rs7303573 ATTCTCTTGCTCTGGG[A/C]ACACTAGTGGGCATTT rs6715897 ATTCTGTTTTTAGTTC[A/G]AGGGCCATTGTTTATT rs702604 ATTGTAGGAACAAATAfC/ηCTATGTGAGTTGAAGA rs3008621 ATTGTGTTCAATAAAA[C/T]CCTTTCATAATTTTAC rs6808202 ATTGTTTCTTGACATA[C/T]GATTACTTTAATTTGT rs4778099 ATTTAAATGAAGCCGTIA/GIAAGTGTGTTTAGGGTG rs4931059 ATTTTCATCCAGAGGC[G/T]CCTGAAACAGCCACCG rs6862278 ATTTTGAGTCATGAAA[A/G]TTACCTTCCTACAGAG rs4548801 AI I I I I ICAATTCAAC[C/T]AGATTTTCTGGGGAGG rs648638 CAAAAGCACGGGTAAC[C/G]AATGCAAAAATTGATA rs7295430 CAAAATATTATCTTTC[A/G]CCATGCCCAGAGGAAG rs4773709 CAAAG AACGCTTAATG [G/T] AAGGAAG AAGTATTAG rs453572 CAAAGACCTACCAAAA[C/G]ATGGATGATTCTGAAA rs536730 CAAAGTAATGTGAGTA[C/G]GATCCCTGCAAAGTTC rs4936618 CAAATGGCCTGCAATG [G/T] AGTGTTCGGTAAGGGT rs6583607 CAAATTAAAACCAAAA[C/T]GAAGTATCGCCTCACA rs4027132 CAAATTCAAAGTTCAA[A/G]TCGTATTTCTGGCTAA rs6429453 CAACTGTAGTGGATAA[C/T]GTCAAGTTG I I I I I CT rs6925350 CAAGATACATATCTGA[A/G]CTATCACCATAAAGCT rs289450 CAAGCATATCTGAATC[A/G]AGAAAAGCAGACATGA rs4334629 CAAGGACGAAAGATAC[A/G]CAACCAAGGGAATCAC rs3845948 CAAGTATGGCACAGGC[A/G]ATAAAACTGTCTGCAG rs7236575 CAATACTGAGGAAATA[C/T]GGTTAGTTTTCAAAAG rs244885 CACAAGACCTTTCACA[C/T]GTTATTTCATTTCATC rs2828098 CACACACAGAGTACCC[C/T]GGCAAAATCTGGTGGA rs4846657 CACACATTTTTGAAGT[C/T]AAGTCTTTGTTCTTTC rs254287 CACAGTG CATTATCAA [A/C] C I I I I I I I AGACGGGG rs4771911 CGCAGAGATCACAAAA[C/T]GTGTCCCGCAGAAGGG rs4843568 CACCAGCCAGGTGAGA[A/G]AGAAGATCGGTGACAA rs2286385 CACTACAAAAAGTACA[C/T]TCCACAATGAGTAAGA rs6809087 CACTGCCTTAGAACAT[A/G]AGTGCTTCCATACAGA

rs6065466 CACTG G GAAGTTG CTC [C/T]CCTTAAGTCTCAGTTT rs6882270 CACTTTAATCTTGTGA[G/T]ACTAAGACTAAGCTGT rs7114320 CACTTTGCATAAGAGA[C/G]ATTCCTCTGGTATGTT rs7199581 CAGAGTGGATCCGAAC[A/G]CTTTACAGAAATTGGA rs6478513 CAGAGTGTTAAAGTAA[C/G]TGGCCTAAGGTGTACA rs470455 CAGATGGTCACTTCAT[C/T]AGCATAAACACTAAGC rs2858638 CAGGAACAGTTATCAA[C/T]TCATCCCTGTCTCCTC rs4372536 CAGGAAGATGTGAAGC[G/T]CTTTACACTGCAGGAT rs4911536 CAGGGGTATCAGCGAC[C/T]GGGATGCGAAGGTAGG rs3108066 CAGTAGACTGAGTGAA[AZG]AAGAGCTGCTCTTAGT rs4933346 CAGTTCTCTAGCTGTA[C/T]GGTTCTGAATCATTTG rs4728666 CAGTTTATGTCCTTCA[A/G]TCTAACTTTTCTGCTA rs2513077 CATAAGATGTCAATCA[AZG]TACATACAAGACATAC rs4573006 CATATTCCAGGGCTAC[A/G]CTGTTTTACAAAATCA rs4677766 CATCACCATGCATTCC[A/G]CACGAACCTGTGTTAA rs4441646 CATCATTAATGTGAAC[G/T]CGAGCAAATAAAAGAA rs720727 CATCTATAAGTGTCG G [C/T] CACAAG CATCTACTAC rs2412524 CATCTTGTGGAGCACA[G/T]AATCACTTTTTCCTTG rs360089 CATGCAAACCTGCCTA[G/T]GAGAGCGTCCATTGAC rs2195839 CATGGAGGAGAAAACAtC/T]GGAATAGATCACACAG rs6960667 CATGGTGAATGTCAGA[CZT]AAGTGTGAAATAAACT rs4667810 CATGTTAAAGTACCCA[A/G]AATCCATCCAACTGAA rs6547953 CATTAATTCAAAACAA[C/T]ACTTGACATCCTAGTC rs6977739 CATTTATAAATCCACC[A/C]AGCAAACATATGAGGC rs4741793 CCAAAGTTCTAATGAA[A/T]TCCAAAGCATCATAGT rs615031 CCAAATATTGCCGTCA[A/T]AATTAGCTAAAAGAAT rs257654 CCACATCTCCTAAATC[AZG]CGATCCTGGGCCAGTA rs6894886 CCACTC AAG AATG CTG [A/G] ACAATCGTTAACACTA rs226408 CCACTGGCTTGTTTCA[CZG]GGATAAAACTCTGTTT rs2864246 CCAGATGGAAACTGAC[C/T]GAGAATAGTTTGGCAG rs6994076 CCAGGCTTTCATAGAC[A/T]CAATCATATAACAGCT rs2445290 CCAGGTCATTCACTGC[C/T]AAGATGGAAATAAAGT rs3743033 CCAGTACCTTATTCAA[C/G]CCAAATGAAGGTTTAT rs2354324 CCAGTTATTCCCCTGA[C/T]GGTAAGCCCTATATAC rs6960707 CCATG I I I I I GCCACA[A/G]TATTGTAACCTGAGAT rs7193418 CCATTCGGGCACTTGG[A/C]AGAGTTTACAGTGCAG rs2136897 CCATTTAGCTTCTAGC[A/G] ATAGTTTTCTAGAGTC rs4403634 CCC AAAC AACTCCTG G [A/C] AATTCTTCTTGCTTTC rs6124066 CCCACAAACTGAGAGA[A/G]ATGTGTAGAAACAGGC rs603151 CCCACAGGGGGTGGAA[C/G]GACAAGCAAGTAACCA rs225487 CCCAGGGCAGTTGTGG[A/G]ATAATTAGTAATAGCA rs304215 CCCATCCTTTAAACAGIA/GlAACAGTTTGTGAAGAT rs349447 CCCATGGTGTTAGCCA[C/G]GGCTCAAGAATGAAGC rs6857087 CCCCACACACCTAGCC[A/G]CTATGCAATGACTCAG rs35774871 CCCTAAAACTATCACA[C/T]AGCTGGTTCCTTCTGA rs4866555 CCCTAAACTGCTAAAA[A/G]AATTGCTGATTCTGTG rs4901755 CCCTGGAATCTGGAACIG/TIAAGATCAAGCCTTTTG

rs7248486 CCCTTGACTGTCATAC[A/C]CTGTGGTCATATGAAC rs6866354 CCGGAAGCACTATTTA[G/T]ATACACTATGCCACCA rs4739079 CCGTTTTCTGCATCTC[A/T]ATTGTATCCACGAAAT rs7253956 CCTAGAGGACCTGGGA[C/T]CAAGCTGCTAGACCAC rs2244672 CCTATTAAGGAGACTC[A/G]GAAATAGCTCTCATTC rs4900914 TTTCTCTTTGATTTCA[C/T]GTGTATATCATTTCCT rs6439200 CCTCATCAGTGGTGAG[C/T]CCATCAACCTTGGATT rs4430153 CCTCATCTGCCTCTCA[G/T]GAAAGTGGA1TTTTGA rs2471512 CCTCTTGGAAAAACTG[A/G]AAGTAGATCCTTGATG rs562966 CCTGCGTTTCTTGGGC[C/T]CTGCCAAACTGTACTG rs4661539 CCTGG AGCCTGGCATG[A/C]AGTTAACATACAAG AA rs496584 CCTGGGGACCCTTCAA[C/T]CAAACCATTTTCAATT rs6959108 CCTGGTGACAAACTCAIA/GICACTTATGATAGTATT rs6864026 CCTGTGAAGTTGCTGA[C/T]GCGACTCAATTTAATG rs454266 CCTGTGTCAATATATA[A/G]CTmTCTTTATGCAT rs5752554 CCTGTTTTCAGATGGG[A/G]AGACCAGGACTTGGAG rs2967793 CCTTTATCTTCCCTTTIC/GIAAAATCTAAGCCTATC rs257741 CCTTTGTAGATGTTGA[C/T]GAAAACAATCTGTTAC rs6050183 CCTTTTCCTGGTAACA[A/G]TCCTCACAACAAATCT rs7213631 CGATTTAGTGAGTATC[A/C]ATCTGGTATCCATTTC rs369651 CGCTTTGAGAGGGAAA[C/T]GCAGATAGGCGATCAT rs6745998 CGGCAATAGCTTGCAA[C/G]TGATAATAAAGGAAGG rs246277 CGGTCACAGTTAACTT[A/T]AAGAGCATACTGAATA rs661609 CGTCACATTGTCCAAA[A/T]TGGCTCATCACCTCCG rs2087273 CGTCATATGGCTTCAA[A/G]TGAGTAGTGACTAGTG rs2075383 CGTTCCTAGAAGAGAC[A/G]GAGAGCGCTGACTGAA rs2239961 CGTTGCAG AGGTCTAG [A/G]AAGGCTGGTTTG AAG A rs6488711 CTAAATATTAAGCAAGIC/TJAGTAGAAGCAAGGAAT rs2334063 CTAATGGAGATATACA[A/G]TAAGACGAATGTTGTT rs7236642 CTAATGTAAACATGTC[A/T]CTTGCTCTCTCAATAT rs6883415 CTACACAGAGATTAGAIC/TJGCCAGCCTCAGCTACT rs4142863 CTAGAAGTATTTTGCA[C/T]CATCCAACCTTCATTC rs448666 CTAGGAACTATCCATT[A/G]AAATTTTCCTGTTAAG rs2104042 CTAG GTATTCATC ATC [A/G] G AATGG AGTTGGATTG rs408483 CTATAGTTTCCTTATA[C/T]CCAATGGCTTGTCGCT rs7133648 CTATC ATCATCCTG CA [C/T]CACAGTTGTATTTCTG rs6822958 CTATGAACCAGGAAGA[A/T]GATGAAAATGTGCTAG rs6032948 CTCAAAACACTGATTC[C/T]GAAACTCTAATAAAAG rs3762365 CTCAAGCTGAAATCAC[G/T]ATCCCATCCTTCAGAG rs304207 CTCACATCACACACTA[A/G]AAGAGTCATTTCCAAA rs7300192 CTCAGCAAACATAACT[C/T]ACATTCCATTCATGGA rs6128872 CTCAGTCTGCAAAAAC[C/G]CTGATGCGCAGGTGAC rs6756764 CTCCAGCCATTGCCAA[A/G]CTGCAGTCCTATTATT rs7236715 CTCCTACCACTCTAAC[C/T]ATACTGCGGTCTCTGT rs7124872 CTCCTTTAACGTTTTA[C/T]ACTTCCAGGTGTCAAC rs7233192 CTCTAAGGTTTAGTCA[C/G]TCTTGGGGGCACACCT rs2190963 CTCTACATGACTCTTG[A/C]AACTTGATTTACTCCT

rs4490884 CTCTGG ACTCTGGCAG[A/G] ATGGTAG AGAAG ATGC rs2849395 CTCTGGTCTCCCACAA[AZT]CCTGAGCTGCCTCCAG rs347558 CTCTGTCCTGGAATAA[C/T]CCTGCAATTAGGAAGT rs6665381 CTCTTTTCTTCACAAA[C/T]TCCTCAGTCTCATGTA rs284688 CTGAACCTCCTGAAAC[A/G]GAGAGCTGAAACAGAG rs7317235 CTGAAGTCCTTGCTGC[C/T]AGTTCAAACTTGTTCA rs4657486 CTGATCCGCTTTCCCA[A/G]ACCAGTTATTTGTTGT rs4645337 CTGCAACAACAGAATA[CZG]TAATGCACTGTCATGA rs6597689 CTGCATGATAATAGTA[C/T]GGTGTCAAGGTTAAAT rs2842754 CTGCCTTAGTAGGTAA[C/T]TGAAACATTGTAGCAG rs4783894 CTGCCTTGACATTCTA[C/T]GACTTTAAAATCAAAG rs2404535 CTGCTCTCACTGATTC[A/G]ATATCTTAGGTCTGTT rs7117210 CTGGAAGGACGAGATGtA/GlAGATACATTTGGGTAT rs3104704 CTGTACATTAATACCC[C/T]AAGAGGCAATGTAAGG rs2176696 CTGTAGCTCTTGAGGC[A/G]ATGAAACAGCGCTGAG rs2088707 CTGTTTACTTGCTCCA[A/G]TCTGGCCACACTGGCC rs4076277 CTGTTTCTTTGCCCAA[C/T]AATACACATCATCATG rs4866542 CTTAAGCATGGCTGAA[C/T]GTCCAGAGAACATTTC rs3809485 CTTAGCTCTTTGCTTA[C/T]GGTGTTGCCAAATTCC rs6790634 CTTATGAGAAGCAACA[A/G]CTAGGAAAGGTGAGGG rs363035 CTTATGTACAAATCAAIA/GICAGTTCAATTTGCTTG rs3740293 CTTCTCACTGAACATT[AZC]AAATGAGGCCCAGGGA rs26217 CTTGTTGACATTAGTA[CZT]GTGAGGACAAGTCCTG rs6472346 CTTTAGACACAAAATG[CZT]CAGGCAAAAAATAAAA rs2647442 CTTTCCTCTGTCTTCC[CZT]CATTTCTGCTACTGGG rs4377567 CTTTG AG AGCATG AAG [CZG]AGGGTCTTCTAACCTA rs2465791 CTTTGCAAATTAAATA[CZT]CTGCTGAAGTTGCTCT rs281243 CTTTGCCATCCGCAGA[CZT]AGCTTAAAGTTAACCA rs4456715 CTTTTCTGATGAAGGG[CZG]CACTTCCAAGAGGAGG rs34319350 CTmTGTACTATTGA[AZC]TATGATTG ACTCCCAT rs6114956 GAAAAACAAATCTTGC[AZC]ACGTAGACGGTGGCTC rs4873713 GAAAACAATATAGACA[AZG]TCAAAGGGTCAAAAAA rs7029315 GAAAATATTTGAGGAT[AZG]AATGTCTAAATGCAAG rs4923872 GAAACATAAGCTCTTA[CZT]AGGTCTAAAGCCTGCC rs2547353 GAAATGTCGCTATGGT[CZG]AACTCTGAGATGTGAT rs259997 GAAATTCCATCAAGAA[AZG]CTGGCTCTGAGCTCTC rs292069 GAAGAATATCTAGCAG[CZT]ATAGTAAAAGTGAAAG rs7047415 GAAGCAACTTAGTTTC[CZT]CAATGAAAGCTGTAAC rs3114081 GAAGTGTGTCTCTCTA[AZC]A I I I I I I GTCACCTAC rs2254193 GAAGTTTACATAGAAA[GZT]GAACCTTCACACAGCT rs4315060 GAATAAAAGTATATCA[CZT]GGGAGTTACCTCTGTC rs2254221 GAATCTCCAATCTACC[CZT]CACAAGTGCTTACACC rs2907334 GAATGCCTATCGATGA[CZT]GTGAGTGTTGAATAGG rs2468255 GACAATCAGAAGGATC[AZG]AATGTTG I I I I I AAAG rs2243614 GACCATCACACAGACA[CZT]TGACTTAATATTCTCC rs4895849 GACCTGAGAGTAATGA[CZT]GTAGTGTATCTGCTGG rs2244676 GACTAGGCAATTTACA[CZT]GAGAAAGAGGTTCAAT

rs34273034 GACTCATTAAGAAGGA[C/T]TAGACTAGTTGGGAAG rs4923876 CAGAATTTAATACTTA[C/T]GCTGGCTACAGTAGGG rs4924481 AAGTAAACAAACGTCC[C/T]GCCAGCTGTGGCCGAG rs2412531 GACTGACTCAACCCCC[C/G]AGACCAACAGGCTGAC rs6546797 GACTTGCATCTAAAGT[A/G]AAGCTTTGCTCCTGAG rs4902490 GACTTTCATCAGGACA[C/T]AGAGTGGCAGTCATGT rs226799 GAGAACTGCAGCTGTA[A/C]GAGAGGATTGCCCATG rs2447208 AAAACCAATGGAGTTA[C/T]GCTATACTTATTTCTA rs4936625 GAGAG AATCCTGTCAG[C/T]ACAAGCCTGGCGTCGT rs6999595 GAGAGAGAGCTAAAAC[A/G]CATCCTTCATCCACCT rs629875 GAGATATAATTCATAC[C/T]CACCTGAAGTGTACAT rs2646261 GAGCAGTCTTTAAACA[C/T]GGGCAGTGCACGCACA rs4775711 CCTCCTGTTGTAGCTA[C/T]GGACTACCTTAAGGAG rs6552719 GAGGACTAAACAAGGT[A/G]ACACTTACACAGGTAC rs2394999 GAGGCCTCTGCTGTGA[C/T]TCAACTATGTGGGCCT rs340297 GAGGCCTTCAACCCTA[A/G]TAACTGCTTTATCATC rs357897 GAGGGAAAATTCAAGAtC/TlGTCTGGATTTTAGAGG rs664093 GAGGGACACAGTGGAA[A/G]AGACCTGTTCAGTATC rs4964292 GAGGGTAGATGGGAGA[CyT]GAACCAATGAAATAGT rs4422395 GAGGTGAGCATAGAGTtC/TJAAGGGGGTTGGGATAC rs7301998 GAGTTCCCAACCATGA[C/T]GGGATGTGGGTAGAAC rs4810575 GAGTTCTACTGTGGAA[C/T]ATTCATCTTCATGAGG rs7111826 GATAAGACATGAAACAIA/GJATTCCTAATTAAGTTA rs7308867 GATATAAAAATGCCCA[A/G]TCCTAACACACTACTG rs6595512 GATCACATCAGAGTTGIA/TJAAATATATGCCTCAGT rs4793378 GATCTACTTGGCTCCA[A/C]ATTCCACACTGTCTTC rs4146404 GATTACAGCTACATTC[A/C]ATAAACACTTTTAAAA rs4461205 GATTACCCTCACACTC[C/T]CCTTGTTAAAAGCTCC rs4663163 GATTCAATCTGCTCTC[C/T]ACTGACGTGTTCTGTT rs6801579 GCAAATACCTCTATGG[A/T]CACTAAGTGGCTGCGC rs6673069 GCAAATAGCATCCAGG[A/G]AACTGGCAAG ATCAGG rs2135518 GCAATATCATGTATAA[C/T]ATCATGGCTTGTCTCA rs2104043 GCAATCAATTCTGCAG[C/T]AGTTATCAGCACGTTG rs220673 GCMTCTATTGGCTAT[A/C]AGACCTTAAAACTTAT rs354391 GCAATTCAAACCTTTC[A/C]AATGTGAGATAATGCA rs2269252 GCAGAAAGGCTTCTCC[A/G]ACCAGGCAGATGTATG rs3750595 GCAGAGATAGCAGAAAIG/TJCAAGAAAAAGGTTGGA rs34266279 GCAGCATGCGGTCCAA[A/C]GTAATAAACAGATGTC rs3804775 GCAGCATGTAAAAGAC[C/T]ACTGGACTGGCAGTTG rs6081676 GCAGGGATTTCATGTA[C/T]GTGATGAGAGACTCCT rs4236836 GCATAAAAAAATCAAA[C/G]AGACGGCAGGCCTTGG rs7242256 GCATCAAACAGGCAAAIC/TJGGAAGAACCATGAAGG rs312864 GCATCCTTCCGTGCGG[C/T]CAAGTTGGAGAACAGA rs3917768 GCCAAAATTTGGGCGC[A/C]GATTCCACCACTTGGT rs432793 GCCACTTAGACCCACA[C/G]AGAGATGTTACCGGCC rs7101928 GCCAGACATTGTAAAG[A/G]CCAGCTGATCATTGGT rs2502845 GCCAGGAAGAGTTAGCIA/GJAGTAGAATACTATAAT

rs682970 GCCATCTCATCTCATG[A/G]AGACGCAAAATGGTGT rs4713674 GCCCCATCAGCAGAAA[C/T]TAGCCCTGGAGTCTCC rs2343468 GCCC I I I I I GGAACAA[A/C]CTTCTTGAGGATAGAG rs4738836 GCCGTGGCAACTCAAC[A/G]ACAAAGTGCTGGCTCG rs226383 GCCTACAGACAGGACA[A/C]CTTCAAAAAGGAAAGA rs7111704 GCCTATCTATCTAACA[A/C]CTCTGACAACAGAAGA rs2937813 GCCTCAAGTCCTGGGA[A/T]GCACTTACTATTATTA rs2171304 GCGTTAGAATTAGAGA[C/G]GAGCCTGTGACGCTTG rs2115198 GCTAAACATCCTATAA[C/T]GTGTAGGACAACCCCC rs4060121 GCTACCTCTAGGGTCA[C/G] AGAAGTGG ATG AGAG A rs5003737 GCTCAGACTCTGAACA[A/G]CGATGAATTCTAAAAG rs7264679 GCTCCAGGGACCCTAA[C/T]GATCAGACTCTTTCAC rs3821374 GCTCCCATCCTAAACA[C/T]GCACAACCTGAAAGAG rs4881336 GCTGCAAGTGGCTTAA[C/T]GATATGTTCCTGGAAG rs2953310 GCTTCAAGCACTTGAG[A/G]CACTTGG AAATCCTAC rs6493278 GCTTTCAAGACAAACA[C/T]GAGAGAGAGAGCCCAA rs2930629 GGAAAAAACTCTTGTA[A/G]GATATGTTTGGTGGTT rs2219547 GGAAAAATTTGGTAAAtA/GITCTGCAAATAGGAAGA rs4757711 GGAAAAGGTGGTTTTC[AZG]AGAATTTCTAGAGCAT rs7272436 GGAAGAGAAACAGACT[C/G]AGTAGCCCAGGCCAGT rs3883317 GGAAGAGTCCAAATGT[C/T]AAATATGGTTCCAGGA rs7299538 GGAATCCTTCAGATAC[C/T]AAACCGAGGAAAGAAC rs4597881 GGAATGAAATAATGGA[C/T]GGTATTTGCAGCAACC rs4508971 GGAGCTCGGACTATAA[C/T]GGAGCAATGGGGAACA rs408510 GGAGGGGCTTGAGTAA[A/G]GCATGACCCAAAGGTC rs2444242 GGAGTCCAGTCGTTAG[C/T]AGGAGTTCTGGAGGAG rs575559 GTAGAAACAATGTAAA[A/C]AATCTCTCTGTGAAGA rs4659819 GTATCCTTCAAATTCA[A/G]ACTACTAACAATCTGC rs7175582 GTCATTGGTTTCTGTG[A/G]ACCTCAGTTTCTATTC rs3874517 AACTTCAACTAAATTG[C/T]ACTGGACTATCTGGAT rs2503293 TAACCAAAGAGAGCTA[A/C]AAAATTAATGAAATTC rs6814800 TAAGGACACAGATTCA[C/T]GGGTGAGCTTTAGGGG rs3735825 TCATCTCATGGCTGCA[C/G]GAAGTCAGTGTCTAAC rs2936534 TCCATAGAATTACTAA[A/G]CAGCTCCTCATAGTTT rs4685409 TGACCTTTCCACAGCA[C/G]TAATGTTGCTGACTCT rs4736185 TGGGGCACAGATACAC[C/T]GAGTAACTTGTCCAAG rs2321816 TGTACGCATTTAATAA[C/T]GTACTATTTGCTTCTA rs632248 GGCTAAGGTAACAACC[A/G]GAAGGTACTCATTCCA rs6676401 TTCTCTGCCTATGTCC[C/T]AATTTAAAACCTACAC rs6506901 TTGAGACTGCAATTAC[C/T]AGAAAACACTGCTATA rs7202791 TTTCAGATTAGAAGAA[C/T]GTTTCAAACCATTTCT rs2372905 TTTGCATATCCCTAAT[C/G]ATGAGTGGTATTGAGC rs6780191 TTTTCCACACCTGGAA[A/G]CTCTACATTGGTATTT rs6711891 AGAACTGAAATGACAA[G/T]GCTCACCTATCCCCAC rs363032 CCATGGAATTAACTGA[C/T]GTCCCTTCAGTGTTCT rs610494 CAAAGGCTTCTGTTCA[A/T]AGGGAAGCTTTGCTGG rs2419533 TCCATCTCTTAAGCCA[C/T]GAGAGGAGACAGATTT

rs4701434 GTTAATATTAAACTGA[C/T]CCGTCTL I I I I I GCCT rs3910183 CXrTCCTTATCrCTAA[G/T]TTAAACATCTCTATTT rs3846820 CAAAATTCTAAAATAT[A/T]AGAGTGCAGTTGTCAT rs4130030 TmCTATGGTTTGAA[C/G]TCTTGGTAATTACCTC rs424301 AG AGTGTGCGCTCAAG[C/T] AGGAAAG AAGTAGCAT rs7244113 AGCAGGTCAGTATCTG[A/T]CAAAATTCTCAAGGAA rs6720074 AGAAGATAACTGCATA[A/T]AGAGAGAGAACTCTGG rs4440442 CTAGATACCTCTCAAA[C/T]CTTTGTGCTTGTCCAA rs7009315 GGATTCAGCAGACCTA[G/T]GTTCTAGTTCAGGCTT rs2248225 TCGGTATGTGAGCAAA[C/T]GTTAAATGACATAGTG rs2833998 AAGACACCTTATAACC[A/G]AGGACTTAAAGTGAGA rs6518240 TGGTTGTTTAACACAA[C/T]GTGGTGACCTTCGGCA rs7120706 AATGGGTTACAAGCAA[C/T]AATGGATCACCTCCAA rs4716113 AAAATAGGGATAATAAIC/TIAGCACTCTCAGAGTTG rs4726563 AAACCCATGGTAGGGC[G/T]CGGCTTAAAAAGAGTC rs6866929 AACAAATAAAGGTCTC[C/T]ACGTACAGATTTGGAG rs6547260 AACAGAAAATTAAGATIA/CJAGATTGGCTAACAAGA rs584125 AATGTTACAGGG AGAG [A/G] AATG AAGTGG AGTTGC rs2185427 AATTTGCCTGTCTTCAIG/TIATAATACTGATACTTT rs6743009 ACAGCTGCCTACTGGA[A/T]ACATATACTTGCATTT rs3858637 AGAACAGACAACTCAC[G/T]ATCTTTGAGTCTATTT rs2964003 AGAGACTTCATCATCA[C/T]GCTCTGCTGTCTGCAC rs2244671 AGTACATTTGCCAGGC[A/G]GATAGTTACATAATAT rs6553089 ATAGCATCAGTCTTAA[A/G]GCTCTAATATAAACAA rs4976983 ATCATGCTAGGGTCAC[A/G]CAATGTCATCTTCTGC rs2699365 ATCCACGGATATAGAA[A/C]CCATGAATGTGGAGGG rs4814709 ATCCCCCACCAGAGTC[A/G]CACATTTGTTCATTAT rs4869544 ATCGTTCCAGTCTTAG [C/T] ATATGTG CTG CCAAAG rs4141372 ATGTAACTCTTATAGA[A/C]CTCTCCCTCAAATCTC rs4303932 ATπAGTTTCACCACA[C/T]TGAGGCACAACTTAGA rs4528272 CAAAGATATTCAGGAA[A/C]CAACAAGGTAAAATTT rs645170 CACTGGCCTGGGGTAGIG/TIAGCTAAAGCCATATGC rs4296321 CAGTGCCATAGGAAGA[A/T]GTGCTCAAGAAGCGTG rs2981277 CCAATGAACAGAAACC[A/G]GGGGCAACGTATGTTT rs7302914 CCATGCCAACCGGTGC[G/T]CTGCCAACACCACTGC rs7070694 CCCCAGGACTGCTCTA[C/T]GGGCTGCTCTGAGTAT rs6948497 CTCAGTTG AAATTCAG [C/T] AATCCCTGTGTCGCCT rs4362550 CTGAGAATATTTGCCA[C/T]GATGTTGCAGAGTTTA rs4244347 CTGGCAGAGCCTAATAIA/CJAGTGTAAAACAGTAAA rs2731640 GAAAGTAAAGGTAGAAlA/TJCCCCTGATAAACTGAT rs2851870 GAAAGTGCCAGGGGAA[C/G]TGCAACTTGGCAATGG rs2508492 GAGAGAGAAAGTGGAAIA/GJGAAACAAAATGAACAG rs535620 GATCCTGGAGCTCAGA[C/T]GTAAGGTGTGCTAGAG rs2324614 GCAATAAAGAGAATTAIA/GJGCAGGCTGGCTTCTGG rs4796354 GCAGGAAGGTTCAGGC[A/G]GACTCATAGTGTGGGG rs3813582 GCCGTAAGTCAAGTCA[A/G]GTACCCAGGTGGTTAA rs2851912 GCCTCCAGTCACACAA[A/G]CCTGCTAATCCGTGAC

rs28718824 GCTACTGCGCTCAATA[A/G]CACTTATTATTTATCC rs2631041 GCTTCACTATGTGACA[C/T]TATTAAAATTTTCATA rs298182 GCTTCCTGAACAAGCA[A/G]GGACACTGTCAAACAC rs7087529 GGAATTAAG ACCCCAG [C/T] AACTAGTG AAATTGTG rs7238248 GGAGAAGAGCAGTTGT[A/G]AATGGGAGGTTGGCAA rs2344863 GGAGCCCATGGAAGGA[C/T]GCCAAAGGGCGCAGCA rs6916438 GGAGCCCTAGAAGGTA[A/G]CAACAATCCTCTTAAA rs2290482 GGCACACACCTACCTA[C/T]AGACATACAGTTTCAG rs6015452 GGCATGTGGTAGAAGAfC/TlGGAGAATTCAATATTG rs4981158 GGCCCAAAAGAATCCA[C/T]ATTTAGAGCTAAAAAG rs407929 GGCCTTTGAGAATTGC[A/G]GAAGGAGCCCACTGGG rs6773962 GGTATATATTCAAAAG [A/G] AAACAATTGTTCTACC rs3820821 GTCAAGTCTGAACCTC[A/G]CATTTTCTCCCATCTG rs2732234 GTCCTGTGGCTGGAAC[A/C]CTGAAGATGTGAGCTT rs7315192 GTCTATGAGAACAAAA[A/G]GAAAGGAACAACTTTT rs4569270 GTCTTCCCATTGCAAA[A/T]GCCTTAATCACAGGCA rs526061 GTGCTCCTATAAGCAC[C/T]GGAATCTGGATAAAAA rs2921571 GTGTGAGTGGGTTGCA[C/T]GTTCAAGATCACAGGC rs7229063 GTTATTGAAACCTACC[A/G]CCACAGATATTCCCAT rs2194349 TAAAAAAATGTAATGCIA/GJAGGTCAGATAACCCCG rs2781572 TGGATTGCACAAAGAA[G/T]ATGTATTTAAGGCTCT rs698823 TACGAAATTGTAATGAIC/TITAAGTGCATATTTTTG rs4905631 TACTATTTACAACACC[C/T]GGCTTAGTAGGGATCA rs722973 TCACCATTATTGGAAA[C/T]GTAGGTAGTGCCCAAA rs3790659 TCACTTTCCTGATGGA[C/T]TCATGGGACTTTTCTG rs6007450 TCAGCTCAGGCTGTTA[C/T]GACAAAAATACCACAG rs28490018 TCATCTGTG AATG AAG [A/G] ATGTCAATATTCAGG A rs4936167 TCATTACAGCAGCTAA[C/T]GTAGGCTAAGCCCACA rs4276176 TCCTTACATGAGAAAC[C/T]GAGAGATAGTATATAT rs2053158 TGGGGTATAGTGTACT[A/T] AACACTG AAGCCTAAT rs3808122 TCTTACAGGCAAAGCA[A/G]CTTGTATAATGGGGAA rs4629927 TGAGTATTACATGTTA[C/G]ATTCTTGGATGCTTTC rs2235757 TGCTGGACCCCTGCTA[C/T]GCCTCAGCACGGATGT rs6817612 TGGAAATCCACATCCC[A/G]GAGACATCTAATTCTT rs7082102 TGG ATCAATAACACAT[A/C] ATAG ATTCAAATACTT rs2359630 TGGATGACTGAATGGC[A/G]GACAGCAACTTCTACC rs592228 TGTATAAACAGGTGAAIC/TJGAAATGTGACATATAC rs6472935 TGTCCAAGTTG ATAAG [C/T] AG ATATAGCTTTCACA rs4789492 TGTGATGAGCTCGGTA[A/G]GCCCGGCGCCTCGCCG rs2717637 TGTGTAGCTGAAGCAA[C/T]ATGAAGCAAAAAGAAC rs2895647 TTACCGTCTAGAAGAC[C/T]GACAAACAACCCCTGC rs3846087 TTACTTGGATTGCAGA[C/T]GGC I I I I I CTCTGGGC rs6567316 TTAGAATGCAAGTTAGμ/GlACCAACATGATTAAAA rs4522813 TTCCAATACTAGGCAA[A/G]CCACAAAGCAGGATCT rs4285402 TTGTAGCTAGGATCCC[A/G]GATGTCTGCAGTGCAA rs6671984 I I I I I l ATAGTGGCTAfc/ηATTAGAGTTAGTTTTC rs6760957 TTTAAAACATGTCAAGfC/TjAGTAGAAAGTAGGGTG

rs2832648 TGAAGATATGAGCTTAIC/TIAGTCTAATGGGAAAAA rs2250259 GTAGTTGTCACTGTGA[AZG]CTAGGCAAGCCTTTCT rs2093852 AACCTCTAAACAGCAT[A/G]AAAGGGATCAGCTCAC rs642783 GTTTAGTATTGCCATA[A/T]CCTCTCAGTGAGAGAA rs4133295 TTAACCAAGTGAGGCA[C/T]GTTGTTCTGATCTCAG rs2046535 GAGGAGGAAGACCTGA[CZT]ACAATGAATGAACAGT rs6596989 CCACCTTGTATGAGAG[A/G]AGCTACTTAGGTGTTT rs2395672 GTGCAACAGATTTTCA[A/G]AAGTTTTCATTTTGCA rs726820 GATGGGCACAAAGACA[C/T]GGAGAATTCCAGGTGG rs6975798 GTCTGATGTTATTGAA[AZG]TAGGATGTTCACTTGA rs2738078 GCTCTGATGTGGCCAC[C/T]GTGATTAACGCAATCA rs268599 AACTCACCAAAATTGG[G/T] AAATAG AAAGCATTTT rs2169089 AAAGTAGCAATTGAAAIC/TIGATGAGAAGCTAAAGG rs4805218 TGGATCTCACTCTATC[AZG]CTGTTATATGTTACGT rs2551677 CAGGATTTAACTCGCC[CZT]ATGATATAGAACACAA rs6476126 GGCAGAATTCTTTCCC[CZG]CTTTGCCAGAGGAAAA rs2826684 CTGTTCCTCAGATATA[AZG]ATGCTAGAGGAGATGG rs2142090 TAAGGCCATCTTCCCC[CZT]GACCTCTGTGTAAAGG rs465576 CTTCTGGCAGGCAAGA[AZC]GTTATGCTACTTATAA rs2838964 TCCCTCTTCAATAAAC[CZT]CTTATCTGCAAAGCCT rs6541155 AAAACAA I I I I I AAGA[CZT]ATTGGCTATTAGTCAA rs603397 AACAGAGTAAAAAGAC[AZT]ATCTAAAGAATGGGAA rs4233760 AACATGTCAGATATGC[CZT]GCAGATGGCTGAGATA rs6877822 AACCTGATTCTAAATA[CZT]GTACAGAGGGTAATGG rs2192859 ACATTTGTAATTTGAA[AZG]TCTTGGGGAATAGTGA rs2675967 ACCATCCTACAGATGA[CZG]GAGAAGGCACAGAGAG rs6831744 ACCCTAAGGCAAGTAA[CZT]GTGACAAACTGGCTTA rs4470330 ACTTAGGCAGTTATCA[AZG]GGTTTCTGGGATTTTT rs7228353 AGAAAACCAGTGAACA[CZG]GCATATGAATTGTTGT rs4266861 AGAGAATTGTTTATGA[CZT]CAGGAATTTGAGGCCA rs6095323 AGAGCAGCTGGACAAC[CZT]CAAATCAACGCTGGAC rs6657700 AGAGTAAAATGACTGT[AZC]AAATTCAAGGAAATAT rs7203756 AG ATCTAGCATTCTTG [AZT]AGACCAATATGCCATT rs3847233 AGCCTATTCTTAGAGT[AZG]AAATTCTTTTCCGTGC rs4280249 AGCTGTTCTGTACTTA[AZC]GTCACACCCAGAATTG rs4146178 AGCTTAGTGGGAGAAT[GZT]ACATCCATTTCTGTCT rs2962792 AGGGAATTTAGGAAAC[AZT]ATAGGAAATCAACACT rs4658507 AGGGAATTTCATGCAG[CZT]CTCCCTTGTGGATGAT rs476179 AGTAATTAATGTTGCA[AZC]AACAACCATTGCCCCA rs6597708 AGTGTCCTGTATCAAT[GZT]AAGAACCTGTTGGGGA rs2791512 ATATGAGACTGGAAGA[CZT]AAGAGAGACTTCCCAC rs6472341 ATCACCAGTTTTAAGG[AZG]ATGAGCAGTAGATGTG rs7047148 ATGAGTCTTTCCCACA[AZG]TGCCTAAAAAGATTCT rs4321205 ATGGACAGTCTTACAA[CZT]TCTGGGTGTGACTTAA rs2066926 ATTGCAGATTACATAA[CZT]TGGGATTAAGTGAGGT rs6505710 ATTTTATTCCTGCTAC[AZG]ATCTTTATTATTTATG rs2683690 CAAAATCATGGCTCCA[CZT]CTCTGTGATATTTTGA

rs4609433 CACATAAGACTTTCAC[A/G]AAGGCAGCTTGGATGT rs6778834 CACTGATTTGGTTGGC[C/T]CTTGAAGGAGTCAGTT rs516810 CAGCTAATCTGAAGTG[C/T]ACTGAGATTCACCCAG rs3950018 CAATTGATAGAGAAAA[A/T]CACAGAGCTCTCCACA rs4489755 CAGGAGGGAACATGGAIA/CICTCATTGCATCCATGC rs221035 CATCCTTCAGGGGTCA[A/G]ATGTTAATTGCCAGGG rs284689 CATCGGTTTGCAGAAC[C/T]GTGTCATGGAAACCAC rs226387 CATGTGTG ATCTTTGG [A/G]CAGGACTATACCTGCT rs5010979 CCTTTGATATCAAGGA[A/G]TCAAGGACGTGATGTT rs6585304 CTAAGCTAACTGAAAA[A/G]ATTGGCATATCACAGG rs6537549 CTATATCTGTATGGAA[C/T]TGTCACAATTATGGAG rs4940957 CTCCCCACAATTTTCA[A/C]AGAATACAATGCATTG rs401859 CTGAGTGGTAATTTCC[A/G]ATTGGATCTCAGACAT rs4424038 CTGCAACTAGCATCAG [C/T] ATGG AAATGG ACCAGC rs2401841 ATAAAATCAAAGGATT[C/G]TTGTCTTCATTATTAT rs6926642 CTTTACGGTAGCGAAA[A/G]TAGCTGACGCACATAT rs617595 GAAACTGAGGCACAGT[A/G]AACTAATTTTCCCAAG rs6102795 GAAATTACACAGTTGT[A/G]AAGTGGCAAACACAAG rs550523 GAAGGCCTTGAAGTCG[A/G]AGCCTGTTTGGTGAGT rs4924304 CAGTTTGGATTCAAGC[A/G]CAGCTπTCTTGGTTC rs2949650 GATGACATTATTGTCC[C/T]ATATGCTAAAACTATT rs2144825 GCAACCCTACTATCTG [A/C]AGGTATTTTTCACTTC rs4799011 GCACACGTTCACGGAG[A/G]CCTCTCTTGGCAAGCT rs7217945 GCAGTGGCTACATTCC[A/G]GAAAACAGCCGCAGAA rs4777205 GCCAAGACAGATGGCT[G/T]AAAAGGTCACGCTGCT rs6810410 GCCTAACAACAGAGTA[C/T]ACATGAGCCAAAATCT rs226832 GCCTGGATGTTAAAAA[C/G]TGCATCCTCCCTGAGG rs2131887 GCGTAAATTCCAGTCC[A/G]AAAGGTGGCAGGCTCA rs2114913 GGAAAGCAACGAAAGC[A/G]ACGGCAGTTGGACTTC rs9696488 TGTGCAACTTGATGATIA/GJAGAAGGTGGTTTTGAG rs922553 GAGCAGTCTGAGCCAA[A/G]GGTTGAGTAGAGAGCA rs7987244 AAGAAAGTGTACATTC[C/T]AATTCCCTGGACTAAA rs7611310 AATTCTCCTCAAGTGA[C/T]CATTTACGCTTTAGAA rs854537 GGCAGCAGTTATTCCA[C/T]GTTGACCACTCTTATA rs7585499 GGGAATGATTTCTCTA[C/T]GCAAAACTTATTCCAT rs7854466 GGGACAAAGGAAGAGAIA/GJATGCTGTCAAAATCAT rs8044632 GGGACCCAGAGGTCACIA/GJGAATACCAATATGAAT rs9458689 GGGATGATGACATCACIA/GJCAAATGGTCATGAATA rs733508 GGGTGCCTAGGCTTTC[A/G]CATCAAGTGGGACTTG rs910771 GGTGGTCCAGGTTCAA[C/G]TTCCTCATTGCAATAC rs922555 GGTTTGAGGAATGGACIC/TJACTTAGCAGGGCTAAA rs7414079 GTAGAAAAAACGGACC[A/G]AAGTGCCTGCCTAAGG rs845729 GTAGGTAAATTACACC[C/T]AGATAAATTGCAAATA rs7748510 GTCACATGGTCACCAA[G/T]AATTCAGAGGCGGTTG rs7980781 GTCACTGGAAGGTGTA[C/T]ATAGGCTTTTGCCATA rs9875616 GTCATAACCTCCTAAA[C/T]TGATTCACAGCCCACT rs7498488 GTCCTGCGGCATCTAC[A/C]GAACTGGATGTAAGCA

rs7752425 GTGCACGTCCTCTTTG [A/T] AACTCTCCTCAGTAGG rs7838420 GTGTAGAGAAATAGGAlA/ηGAAAGAGGATTTCAAC rs7557611 GTGTATATCTTTCCAC[A/C]AACATATCTACAGTTT rs9592084 GTGTTGGGATGAAGTAIC/TJAAGCAAAAAGCAGGAG rs7868575 GTTGAGAGCTTGAAAGIA/GJACAAAAAGGTAGAGGA rs9364534 GTTTCCTTAAGGCTTA[C/T]ACAAATTGTTTCATGT rs966659 TAAACAACTCTGATAA[C/T]GTAGCTTACTGTCATT rs9686988 TAAAGTATCCTGTGGA[C/T]CAAGGCTAAGGCTAAG rs9933518 TAACTCTTGATGCACT[A/G]AAGGCAAACTACCGGA rs826590 TAATCATTTGAAGGAA[G/T]AATTCACAAGGAGAGC rs7966105 TACAAATAGGACATCA[C/T]GAAAACTGCATCAAAT rs962316 TAGGCCCAATGTGAGA[C/T]AAACTATGTCAGGACC rs881018 TATAAAGGCTTGCCTA[A/G]GTAGGCCAGGACTGAA rs7834887 TATCTGAGAGCCAACC[A/G]CGTGTCAGTCACTGAG rs7742617 TATGGAGGAAATCAAT[C/T]ACAAGTTATCCATAAA rs8057668 TATTTCTCTCTTTCCA[A/G]TACCACCACATTTCCT rs9926403 TCAATGCCATGGAATAtA/GJAATGAGTTGTTGGAAA rs9635573 TCAGAGAACAGAATGA[C/G]CAGTTCAGGAGTTCAG rs9875156 TCAGATCCTTGCCAAG[G/T]AGAAACATTTGATAGC rs748165 TCAGTATAAGGTTTGA[C/T]GTTGACATTTTAACAA rs9891294 TCCAATTAG CCTTAAC [A/C] CTTTC AGTCCTTTTCT rs9815517 TCCATCACAATAAACC[C/T]CTCTTGGCTCCCTTAT rs9697134 TCCCTGATCCATTGAA[C/T]CTAAAAGTCTGAGACT rs9908305 AG AAAAATCTAGCAAG [A/G] ATCAAAG GTTAAGTAC rs9351813 TCTCCAGTTCCTATTA[C/T]AmCTGCCTAATTTT rs9351816 TCTGAACCACAAAGCA[A/C]AAAAATATTCTGAGTG rs7988254 TCTTCCTCTTCTCTAC[A/G]CTTTGAGCTCCTTGAG rs9971316 TG AAATACTGTTATAA[C/T] ACCTG CAAG CTTACAA rs7645279 TGACACAGGCAGGTAA[C/G]ATAAAATTTACCTTTT rs7556846 TGAGAGAACTCCAAGA[A/G]GGATGTCGAAACTGGG rs7847215 TGAGATTTTGCAGTCπC/G] ACTGGTGG AAATAG AC rs7691652 TGCAAACACGAGGAGG[A/C]ACAAAGAGAACGGATT rs8103089 TGCACACAGAGATGAA[C/T]GGGCGAGGCTTCTCAC rs7464175 TGCAGCCTCTGCAACC[G/T]ACTTCCGTGTGCTTTC rs7663340 TGCCTAAGGCAGATACμ/GjAAGAAGAGCAAAAAGA rs9498737 TGCCTACTTTCACGTA[A/T]AGACAATAGTATTAAA rs809639 TGCTGAATAACTGATA[C/G]GTTTTGAGAAAATTTT rs745165 TG CTG CAGTTATGTAG [A/C] AAG CAG GTTGTCATG G rs9423342 TGGACAGGAGCCAGAA[C/T]ATCCAGGCCAACCCAG rs7967892 TGGAGGAAAACCTCAC[C/T]GACTTGGCAACATTTG rs7672620 TGGAGTCTAAGAGTGAIC/ηGTTTGAGCTGAAAATA rs930056 TGGCATCAAAGGTGGG[A/G]ACCTGTCTTTATTATC rs7696553 TGGCCTATGTTGGATA[G/T]ATAAGAGCCAAGTGTT rs7748736 TGGTCTGAAATTGAGA[C/T]GCTTATTGAATGCTTA rs7737281 TGGTGACAAGCATTCA[C/T]GGACCCAATGCAAGTA rs7988514 TGGTTCTGAGGTGAGA[C/T]TAACTAACCTATAAAG rs765188 TGGTTGATAATACCTA[C/T]GTCATAAATTTGTTGG

rs7911998 TGTCTACAGTTCAGTG[A/G]ACAGGCAGTGATGGGC rs979058 TGTGATAACAAACATC[A/G]CAGGTAATTTTGA ^" πT rs7859675 TGTGGGTAGTGATATAtC/ηGGAATTAGTGGGAAAA rs7647840 TGπGGGAGGCTGTAC[A/G]AGCTAAGTGGGAGTGG rs7964939 TGTTTAAAGπAATCA[A/G]GAACCTTACTCTTTCC rs9592445 TGTTTTACAAATAGTA[A/C]CCTTTACAAATAGTAA rs957582 TTAACAAATGCTGTCA[A/C]CTATGAAGGCCAATTT rs9363771 TTATCTACTGATTTAC[A/C]CAATTTACAGAGCCAC rs7638955 TTA I I I I I CAG G GTCC [C/T] C AAAC AACTG CTCTAT rs7807871 TTCCACAAATTGTTAA[A/T]CAAACTTTCTGTAGAA rs7747551 TTCCATAGGAGACTTA[A/T]GCTTTTGGATCTAAAG rs931120 TTCCCAAGCTACACAA[C/G]AAGGCTGAAGAGAAGA rs9317562 TTCCCTG AATAATCAC [G/T] CTTG CC ATTACTTGTC rs7837959 TTG ACTG AATACTTAG [C/T]CACTGCATAAAAAATG rs7505507 TTGCTAAAGATCACAC[A/C]GTAAGTAAATGAAACA rs9540649 TTGCTTACAGGGAAAC[A/G]CTATCTGAGACAAGCT rs8098626 TTGCTTCAGCACTCTA[C/G]CAAAGGCCAACCTCCC rs7962233 TTGGACTTGACGTTTC[C/T]CAGTCTGGTGTGGCTT rs902126 TTGG AGTTGGTAG ACA[A/T]CTTGTG AAAGG AATCA rs9349997 TTGGGACAAGTCGAAT[A/G]AGCTCTCTAAACTTTG rs7972260 TTGTCATAATAACTAC[A/C]ATTTATAGAGTGCCTA rs7832582 TTGTCTTCTCGCTCTA[G/T]AACCCCAGCTTAATGA rs8103254 TTGTGGGAGTACTTTC[C/T]AATGGTATCCGCTGAT rs7334517 TTGTGTAGAGTAACTC[C/T]ATGCGTAAACAGTTTC rs7985116 TTGTTGACTTCCTAGC[C/T]ATGGTCTTTAAAGCTT rs983860 TTTACACGTAAGTCAC[A/C]AATAACACCCAGTGTG rs7646681 TTTATTACTTCCCACA[A/G]TATAATGGTTCCCTGA rs9402666 TTTATTGGAGAGACTA[C/T]GTTTTCACCAATGCAT rs9348953 TTTCCAGCTGTGAGAC[A/G]AAGGAGCAAATATGAG rs8054976 TTTCGACGGGTTCTGT[A/G]ACAAATGTCCACAGAC rs7559074 TTTGGAGCCTACAGCA[C/T]TAGGATGAGGATTAAA rs7590007 TTTTCTGACACATCAA[A/C]ATTTCTCAAGTTCAtC rs7874519 TTTTGACAACCTGCTA[C/T]AAATAATGAGGCTTTT rs9359674 TTTTGTCCTTATTTCA[A/T]TCAGTGCGGTAGTGAG rs8187945 TnTTAAGTAGGTAAA[A/G]TGCTCCCCCAATGTTA rs7668533 TTTTTGTATTTGGAAA[A/G]CTTTGGGTATTGAAAG rs996492 I I I I I I I I ATCAGTTA[C/T]ACAGCTCTTAGCACGA rs8105738 TTTACAAAGCATCTCA[C/G]CTGTCTCCTTGATCAC rs829584 TCTGCAGTTACTCTCA[C/T]TAAGAAGTATGTTAAC rs7549770 AAAAAGTGAGAGTGGCIA/GJAAAAGTATACTTGATA rs8121916 GCCAAAAGATTGATAC[A/C]GCCTGAAAGGAGAGTG rs9976697 AGAGGATTTTCGATGAfA/TlGTGAATGGCAGGAATA rs988292 TGTACATACAACTCAT[A/G]AAATCTACATACATTA rs7632287 TGCACTGAAATGTCCA[C/T]GTTCAAAGTCTAAGGA rs7611991 GACTTGTATCATTTAC[A/G]CTATTTGTCCCAGAAC rs7693333 CAATGTTACTCATGAA[A/C]AGTAGATGATTTGGAA rs970022 CTCTTCATCTTCCTAA[A/G]TCAGTAGGCAGTTCAT

rs7705236 GAATCACTGAAGTCTC[A/C]AGGTTGATAGTAAGAT rs7705409 CCAAAAGCAAAGTGTAIC/TJGTGGAGAAGGTGAGGG rs922552 GCTCAGACTGCTCTGG[A/C]AAACCTGCTGTCTTTG rs922553 GAGCAGTCTGAGCCAA[A/G]GGTTGAGTAGAGAGCA rs922554 TTGGAGGATGCCATAA[A/G]TGACCTCAGAGATTCT rs734442 GGAGAGAGGTAACACA[C/T]CAATAGACAGGTTTCC rs9283873 GAGACTATAACTGCAA[C/ηGGTAAAAAGGCAGGAT rs7747972 ATCTATATTGAATCCA[A/G]CATCTTAAGTTGCCTG rs9343494 ATATGGTAGGACCTTA[C/T]GTGACTGAAGCTATCT rs7778081 AAATGTACTCTTAAAT[C/T]AGGCATACGTTGAAGA rs7413 TAAATCTATCAG ATGG [A/G] AAATCCTGTTACAAAG rs7870302 CTCACCTAAAACCTGC[A/G]GCAATTTCCCTGAGAC rs821931 GACTTGCTGCATTACA[C/G]TGCCCTTTCCAGATCT rs7926119 CAACAGACCGTGTTGA[A/G]TATTGCTTTCCATTGA rs7493192 TG ACTTAGG AGTCAAA[A/G] AGCATGG ATCCTACTG rs9325521 TAGAGATAATAGTACCfA/GlAATAATACGATTGTTG rs830134 GGGTTAAACCCCAGCA[A/G]AAAGTGAGCTTAGTTC rs7621243 TGCATTGCAAAACTCT[A/G] AAGAACAG CATTCTTA rs7655850 AAATACTCAACTCCGA[A/C]TAGCTCTAGTGTTTCA rs753359 ATTGTATGGCCCATTA[G/T]CAAACAGAACGCATTC rs7745522 TATGAAAGAATGTTCA[C/T]CACAACTTTACTCAGA rs9976483 ATATCAAAAGACAATC[C/T]GATGGAAACAACCCAA rs7951266 AAAAACGTCTGTTACA[C/T]AGTTATGCTCTTTTCG rs7559347 AAAAATTAACTTTTGAIA/GICAAATGCAAGTGTTAA rs808251 AAAATGATCTATGACAIC/TIGGGAATATTTGGAGTT rs7709237 AAAATGTCTG CCTATG [A/G] AACAACTCACATCACA rs9309981 AAAATGTGGATTCAAAtA/GlGTCTTAGATATTAAGT rs9561658 AAACTAGGAAGCCAAA[A/G]GTTTAGAAAATAACAA rs907290 AAATAATTTCATCTTC[A/G]CAGTTTAAGAAGGTGG rs7982376 AAATACTAT AC ACTG G [A/C] ACATAAAGAACATATG rs7818331 AAATGGCTGCATTAGAIC/TJGGCAAACAAGAGGTAA rs9995738 AACATTGAGCTTGAAC[C/T]GCACTTTAGATCAAAT rs879703 AACTCTTTTTGTGTGA[A/T]AATGAGAGAAGAGGTG rs9391062 AACTGCTGTGATCCAA[C/T]AAGTCTAAGTAATATA rs858942 AACTGGAAGATGCAGC[C/G]CGACCTTTGTTAATGT rs7987244 AAGAAAGTGTACATTC[C/T]AATTCCCTGGACTAAA rs781731 AAGAGTTGAAAGAATAIA/GJGACAATGAACACCTAT rs7988550 AAGATGTGGCAGCTCC[A/G]ATATCGCCAATCTGGC rs9646596 AAGCCAGAAGTATTCT[C/T]ACCTAGTCCAGTACTA rs982295 AAGCTATAGGTATGTCIA/GJAAAGAGCTAGAAAGGC rs9872164 AAGCTGCATAGATAGA[C/T]AGTGAGCCTTCAGCTA rs7808966 AAGGGCCAGAAGTTGA[A/C]CTTAGGAGACAAAGAT rs9642783 AAGTCAAGGTTCTAAA[C/T]GTCTAAAAGTCACTGA rs986866 AATAAAACAAGAACTA[C/T]GTGGTTTGCTATATTT rs9572780 AATATAGCATAAGTTA[A/G]AGCTAGAGACCTTAAA rs7680113 AATCCATCATCAGGAClA/CjGTACAAATTAAAACAA rs9332066 AATCTCAACTGGGAAA[A/C]TGCTTTAAAGAAATCA

rs9399834 AATGTAATGTGGAATAIA/qAGAATTGGTCCTGAAC rs7611310 AATTCTCCTCAAGTGA[C/T]CATTTACGCTTTAGAA rs9505118 AATTGAAGATTTTGCA[C/T]GGTGTCTTCAGCAGTA rs8082727 AATTGGAAGCATGATA[A/T]GGAACACCGGTTAAAA rs7920751 ACAAAAACAGTATGATIC/GIAGAGGCTCACAGGGAC rs7653379 ACAATATCACAGCATA[C/G]ATATAAACTTTCTGCG rs9924993 ACACCGGTCCCGATCC[A/G]CTTCTACTATCACACG rs807525 ACCAAGCTGGTTAGCA[A/G]CAAAAACAAATAGCTT rs7913419 ACCAATGTTGGGCAGC[A/G]AAACTGTAAAAGTAGT rs9293123 ACCACAAGCAACGGAC[A/T]AGTAGGGGAAGAGTCG rs9457730 ACCATAGTTCCAAAAC[C/G]CTGTTCAAGTAGAAGC rs9901549 ACCCTTCAGTCAAGGA[CZG]GTAGACATCAAGAGCC rs9843093 ACCTCTATTTAGTCAC[A/G]AATTTCTGCAATATCA rs955051 ACGTGCCATAGATCCA[A/C]CCCTCGCTGGTGCTGG rs934609 ACTCTGTACAATCTTA[C/G]GATAAAAGCTTGAAGA rs9920163 ACTGAAGCTACCAGGC[A/C]GACTTAAAAGTAACCC rs9461799 ACTGAGTCCCAATGGG[C/T]AACTGATTGCCTCTTT rs9830266 AGAAAAAACGTAACCA[C/T]AAGAAATGTGAAAGTA rs7982077 AGAAATTTGGTGTGAqC/ηGAAGAAATGGTGGACA rs7535769 AGAAGAGTACACCATGIC/ηCAGTAGTCATCAAAAA rs996091 AGAGGCTTTTTATCTA[A/G]CAGCAGTCAACAAAGA rs7973993 AGATAACCGAAGCTAA[C/T]TGACCACATCCTACTT rs9939736 AGATTCAACTCTAAGA[C/T]GTTTTATGCAGTGATG rs8094588 AGCACTGACTTCAATA[C/T]GTCCATCAATTTTCCA rs7672528 AGCACTTTACATCTGClC/GlAACTCATTATTCAGTT rs7567280 AGCAGACCAAGTGGAA[A/C]TGATTAACCAATCTTA rs7992054 AGCTGTTCTGGAGCAA[A/C]AATACTGTAAAATTAG rs9819830 AGCTTCCAACTACGAA[C/T]GATATTTTAGAAGAGA rs7935913 AGGCACTTAGCATACA[A/G]CAATTAAGATGGAAGT rs8056052 AGGCCACTGAAGCTAC[C/G]GGATTTAGGCTTGGGA rs7342195 AGGGTTTGCGTAAGACtA/GjAAAGAGAAAGAGAGAG rs7753473 AGGTCTGAAATAGGGC[A/G]GCAATATTTCCACTGC rs853956 AGTCAGGAACTTGCAC[C/T]GCTGCCGAGGCAATGC rs7690478 AGTCTACAAACAACAC[A/G]GAGTAATAACATTATA rs782103 AGTGATTTGCTTTTGAIC/T] AATCCTGTG AGGCAGG rs9487891 AGTGCTGAAACCAGGAIC/TJGGATATGGAAAAACTA rs7609541 AGTGTTCTGGTCTGGA[C/T]GAAATGAGAGAACTCC rs7977693 AGTTCTGGGTAATACA[C/T]CTTGAACTGGTGGAAA rs7685386 AGTTGGGGAATAGTAAIC/TJGCAAGTTGAATAAAAC rs922556 ATACCACTCTTTGGAClA/GlACACATTAGCCTAATT rs7908698 ATACCTAGAATTAACA[C/T]ATGACCCAATAATTTC rs962314 ATATACCTGTTATTCAIC/GJCAAAGAAACCTACAGC rs937527 ATATGTTG AAAACTGG [A/G]AAATGGCTTTCTCTTC rs7637853 ATCCAGATTCGAGAAA[C/G]AGTGTCTAGCTATGTC rs9285201 TCCATTGCAAGAACCCIA/GJATAAGTCACTCAACAC rs9463274 ATGAATATGAGCATCAlG/ηGAAGTAGAAATAGAAG rs908110 ATGAGGTATGTTTCAAtA/GJTCATGAAAGGCTTTGA

rs7695033 ATGCAAAATGCACATA[G/T]TAGTAATTAGTCAAAC rs8086400 ATGTATTTTAGGGAAA[C/T]CTGGTACTGGCTGTTA rs9315454 ATTATTAAATGCCTCA[A/C]GACTTAACGGTCAGCC rs9812338 AπCCTAATCCTGGAA[C/T]GAATAGCCCTGCGTCA rs9515093 ATTCGGAAATCCTAAA[A/G]GCAAATCTTAATAGAA rs963264 ATTCTGAGATCTTTCC[A/G]CTATTTCAGGCTCTAG rs7648466 CAAAAAAGGCCTTGCA[C/T]GTGTGATTAAGTCAAG rs8064088 CAAGGG AATCATGAAG [C/G]CTCTGGGCCAGTCTAT rs9892167 CACACACACATAATAG [A/T] ATACTGTTAAGCCATT rs9505117 CACACACATGGGTGAA[C/T]ACCATCTAATAATGAA rs9523993 TATTATTTTAGACAAC[A/G]AGTGCTGCAGAGGGAA rs8115737 CACAGCCTTTTGTACA[C/T]AGCTTTTATGTGGCAA , rs9834708 CACATTTACATTTTAT[C/T]AGGTGAAATTATCTCA rs8000282 CATTTTATTCATCGTA[A/G] C AATTGTC AC AGTACA rs9564847 CACCTAGGCGAATATA[A/T]ACAAGACTCAAAAGCA rs809213 CACGAGACGACTTCAG[A/G]AAGTAAGTAGGGAAAG rs9393366 CACGTGTTATTTGCAA[A/G]GAGAATCTGAATGATA rs7672441 CACTGCTACATCCTCA[C/G]AGTTAAGGAAAATATT rs9827713 CAGAATAGTGAGAAATIA/GJAATCATTGTCTTTGTT rs9300777 AAAACCAAATCTGAAA[C/T]TGAAGCCCAGAGACAA rs9571556 CAGAGCCACACCCCAA[C/T]TTCTAGATTATTTTCT rs7578292 CAGATACAGAATGCAC[A/G]GTATTTGCCGCAGAAT rs9991272 CAGATCTGCAGCAGAA[C/T]TTATTACAGTTAGATT rs7335946 CAGCACTTTGTAATGA[A/G]AATCATGTTGGGCCTG rs765 CAGGAACTGCCTTTTA[C/T]GTCTGCAAATAAACTC rs7765427 CAGGATATTGGACACA[A/T]CTGAAGAGTAAATTCA rs902891 CAGGATGTGCCTTAGG[C/T]ATAATGTCAAATGGGC rs7819717 CAGGTAAGTACACAGA[C/T]GAGAGAAACCATAAAG rs9574869 CAGTTTTCTTCTGGCA[C/T]AGTGTAGAGGTAGACA rs9323200 CATTAAATATTAATCG [A/T] ATG AATG AGTGTGTTG rs7761326 CATTTCCAAGAAGCAA[C/T]GCAAAGTAAGTTTTCC rs791743 CCAACCTATCCCCACA[A/G]GTGAGTAATTAGTGCT rs9639468 CCACGACTCTAAATGA[C/T]CTGCTTTTACTCTTCA rs7628779 CCATGCCCGACAATCA[G/T]ACACTTTTACATCACC rs831663 CCCAACTTGGAGATAA[A/C]CATTGTTAAATATGAA rs9669216 CCCACTGAGCCACTAAfC/GlAAGCCTGGATATGAGA rs7651436 CCCCATTTGCAACTTA[A/C]AGCTTCATCACCTAGG rs9424612 CCCGTGGAATTTCTTA[A/G]CAAGCATAGAGTTAGA rs9857723 CCCTACTCACGTCACC[A/T]ATAAAGACATACATTG rs928579 CCCTGCCCTAATCACC[A/G]AGCAGACAGGCAACAT rs924640 CCCTGGTAATCTCTTA[C/T]GTTGGTGCAAAATTAG rs9521996 CCGGGTAGTCTTGGCA[A/G]TGAGAAGACACTCCAT rs7947110 CCTATAGGAAACACCA[A/G]TAGTGACCTACACAGC rs9908767 CCTGCCACAGGAGCCAIC/TJAGCAGTACCTACCCTA rs7723199 CG AG ACTCTG AGGTTG [A/G]AAAAGGTCATTAAG AC rs980907 CTACCAACACTGTG AG [A/G] AAATTTGG ATATGGAA rs9354486 CTCATACCAGATCTTA[G/T]GTAAAAGGATTTGAGT

rs782113 CTCCCCCATTAACTCA[A/G]CATTCTCTATCTTCTC rs9394187 CTCTGTAATTCTTACA[A/G]TAACCAGCAAAGTCGG rs949229 CTCTTACTCTGTGTTA[C/T]GGAGACTGCCTGGGAC rs9368402 CTCTπGTAGGCTGAA[A/G]GGAAG ^" πTGAAGAAAA rs879574 CTGGCACGTTGTACAT[A/T]ATCAATTGGGATCACA rs782108 CTGGCACTG AAGCACT[A/G] ACTATCTTGAATTCTG rs871419 CTGGGAGAGGGACACA[A/G]TGTAAATCTAGGCATT rs9519630 CTGTGGTCCAGCTCTA[C/G]ACGCCAAAAGGAGAGA rs7678921 CrTAACTTTTCCATCA[C/T]GTTTCTCATCTATTTA rs9922883 CTTACAGACCTGATGC[A/G]CAGCCTTCCTTTCCCA rs778340 CTTGATGGTTTCCCAC[C/T]GCGCTAAGGGCTTGCC rs781758 CTTTGAATGAATGGAC[A/G]AGGTTTCATAACACAT rs8094453 CTTTGTGAGAATGAGA[A/C]ATAAGCACCTCTCCTA rs8080918 CTTTTCCCTCTCAAGA[A/G]CCAGAAACAAAGAGCC rs882869 GAAAACAAAAAGATTA[C/T]GCAAGAGGTCAAGAAG rs8073228 GAAACAGTCATGACAC[C/G]GATTTCCAGGAAGAGA rs9874464 GAAAGCTGATAAAAGAIC/GJATGCTAATGGCAATGA rs841613 GAAATGCAGCATCTCA[A/G]ATAGTTCAGCAGGGAA rs7981243 GAACTGCTTGGGGCTT[A/G]AACCACAGCAATTCAA rs9877228 GAAGAGGCTTCTGTTC[C/G]AAGATTGGAGATGCTA rs7857417 GAAGCTTTACAAACTA[C/T]GGTGGTGATGTCCAGT rs8092690 GAAGGCCTGTGACTGC[A/G]AGGGGCACGAACACAC rs7406339 GAATGGTACCTCTTTA[A/G]CCATCAGTTGGGCACA rs880716 AGTGC I I I I I I GAGTC[A/T]CTCAATCCTTCATAAA rs769267 GACGTCACTAGATCCC[A/G]CAGTTCGAAGATGTTA rs7660053 GAGCCAGGCAATTTAA[C/T]TCTTAGGACTTTTATC rs9317560 G ATAAATG ACTCGTG A[C/T] ATTAATCTGAAGTAAA rs9886596 GATATAGCAATAGCCAIA/GJTAAGCATCTAAAATGA rs9911421 GATTGGTGTTTGACTG[A/C]ATAGCTGGGAATTCTA rs7750426 GATTTCCCTTGTTGAA[A/C]CTTATACACACTTACC rs8107641 GCAAGTCCAAAGTAGAIC/TJGTAAGCAAGAGGCCAG rs937525 GCACAGAG AGGGTGAG [A/C]AACTTATCCAAGGTCA rs7570424 GCACAGAGTAGAGGCA[C/T]GGTAACGATGTGTTGT rs9368793 GCACTCTGCCCTCTGA[C/T]GTTGTGTTTTCCCAGG rs7916489 GCACTTGTGCTTGATA[A/G]AGGCAGAGTAAGTTGA rs7638518 GCAGGATGAAAGCGGG[G/T]AATCATTTTTCAAAAT rs7970563 GCATCCAGGAAAAGCA[C/T]TGCTGGGAAGGTGATA rs965574 GCCTGCAGCTAGGCTA[C/G]AGAGAGTTCTGGAAGA rs7492012 GCGCCCGGCCTTCTCC[C/G]AGGTTTTAAGTGAGGC rs8072903 GCTCGTTAAG ACAAAG [A/C] ATTTTATAGCAGTTGC rs9314727 GGAACACTTTTCAGAA[C/T]TGCTTGATTCCATGGC rs8099832 GGAATTTTTGTAGCCC[A/G]AAGAAACAAGAGCCTA rs9634205 GGACAACTCATAGGTA[C/T]CTGCTTAGATTCTGAG rs9788209 GGAGTCTATGCATAAA[A/C]CTGGCTGTAGATATGC rs9383240 GTATTCAAATCACCCA[A/G]AGTATATTTTATGGCA rs763591 ACTTAAGGGTGCATTT[A/G]TCTGCTGAGTGAAACT rs9888275 GTGACTGCATTGTGAA[A/T]GTTTCTCTACTATAGA

rs7577717 GTGGAAATATTTGAAA[A/G]CATTATCCAAGTACAT rs9420501 TAAAGGCATATCAAAA[C/T]TTCCCAATTAAAACAG rs7895452 TCCAAGAAGCCTATGA[A/T]CTACTGGGGGAGACAG rs978255 TGAATTTTACCTCCCA[A/T]AATCCTCATACATCAT rs9696488 TGTGCAACTTGATGAT[A/G]AGAAGGTGGTTTTGAG rs8047864 TTATCCCCCCACGGAA[C/T]GGATCAAGGCTCATGG rs829573 TTCAGATATATGAAGC[A/T]AGACAAAAACCTCAAG rs9309308 AGGCTGAACATTGAπ[C/T]AAAGTTACCCTGAGGT rs998321 GAAGATCTGCTAAGCAIA/GJGTAAGGGAAATAAATA rs9305856 AATTTGTTCTGTAGTCIC/TJAGAGTGTAATTAAAAG rs7975956 CTGTAATCATATGGGAfA/GJATCTTGAATTAAAGAG rs7910212 AGACAAGGCAAGGCCC[A/G]ATCTTGCAAGTACTGC rs9364250 AGGACCTCTAGGTTAG[C/T]AGAGCATAAAGTTGGA rs8012459 AGGAGAGGGTTAGAAA[A/G]TATGGAATGAAAATAG rs7972470 AGGGTAACTTGTATAGtA/GlAGAAGTGTCTTTCATT rs7841489 ATTAGTTCTAAAGCAG[A/G] AGG AAG ACTTAG AGAA rs737605 ATTCTAACTGATGTTA[A/G]GTGTGATTCAAGCCCA rs7811306 CACACACATACACAAA[A/G]CAGGCAGCTTGCCAAA rs9634125 CCAAACTTGCAACTCA[C/T]ATCTGAAATTGGAAGG rs7842637 CTTATCCTAAGTCTCA[C/T]GCTCCATACAAAAATT rs7764326 GATTTAAAAGATGACA[A/G]CACATTTCTTACTCTT rs9675700 GATTTCCCAAGTGACA[A/G]ATACCCTTGATATGTC rs781730 GCTCCTACCATCAAAT[A/G]ATTCATCATAGCCTAT rs9920389 AAGAGGCAAAAATGAA[C/T]GCAACTAAGTCACTTA rs7516762 GGATGGAGTTCCAGGCIA/GJCTCTTCAGGTAGTAGC rs9584245 GGATTGAAAATTTGAA[C/T]GTTTGCTCAATCCACA rs9426484 GGGGCCCTGTTGGTTC[A/G]CTGATCATGAGAACCT rs7921561 GTCCAAATAGAAACAAIC/TJGGCAGTCAGAGGCTCC rs8083437 GTGGATGAGCATATTC[A/G]AAGTGGCTTGTAGCCA rs951534 CAACAACAGTAGGTTA[A/G]TACTCAGAATGTTTGG rs9390961 TACCTGAAAGATTTCA[C/G]CCATTAAGCCTGACAC rs7501838 CTGTCAAATCAACTCA[C/T]CTTCAACAAAGGAGTC rs982296 TGGTGTTTGAAGTGAA[A/G]CTTTTAGCACAGTTGA rs8004558 TGTGATGAAATTTGAA[C/T]CCAAGAAGCTTGCCTC rs8089273 ACTTACTTGCTAGAAA[A/G]TATGGGACAGGGTCAG rs7485517 TTGGGATTACAGGTAC[A/G]AATCACTGCACACAGC rs9853784 TTGTTATTGGTCTATCIG/TJAGTCTTTATATGTCTT rs8000744 TTGTTGTTGAGTAATG [C/T] AATCTTATCTTCATGG rs7544659 mCCTCTCTCTGTCA[C/T]TCTTGATCITCCTTCT rs7901744 TTTTATCACTCTAAAA[C/G]ACAGTTAATAAGTTTA rs8101149 GAπCTGCACATTATC[A/G]ATATTAACAGCTCCAG rs750576 AGAAAAGAAAGCTCTC[C/T]ACACTCTATTTTCAGA rs7653303 GCAGTAAAGTGCAAAA[C/G]TCAGTGCTGTTGGCTC rs9287229 CCCTTATCTTTGCTCC[A/G]GACTAACCTGTGGCTG rs9325744 ACATACATTTCTCATC[A/G]CGCTCAAGGGACTCTT rs926082 TAGCAACAATCATGCA[C/T]AGTGTGCCTCTACTTC rs982926 AAATCTTAAATCCACA[A/G]GATGAATTACAGACTA

rs9523996 AAATTTTCATACCAAA[C/T] CCCCTC ATCCTCTCTT rs7708902 ACTGCTCTACCCTTGC[G/T]ACCTTAAACTGTACCT rs733299 AGAATTGTGGGGTCCA[G/T]CAAGCCCTAGTGGGAC rs9821016 AGGAAATTGGATTAATlA/GlAAACCTGGCACGTATT rs9502593 ATACTTAATTTTTCCA[A/G]TATGGTCTAGGTTAGA rs9969560 ATCCTGGGTATTGTCC[A/G]CTACCAAAACAGCTTG rs7592852 CACCAAAACACATGAA[A/T]TAACCAAAGCATTTTA rs988026 CAGAAATAAGCAGTTA[A/T]ACAGAGGAAAACTCAG rs9940288 CCCCCGCTGGGCAGCA[C/T]ATCTGTGTTTTGGCAA rs7735132 CCTGTATCAAGCCAAA[C/T]GTGTTCTTTCATTCTG rs973358 CGCATGTGGGCTCAGA[A/G]ACCGCTGGAGCAGAGT rs8071834 CTATTGATATTGATCA[C/T]CTGGCCAATGCACTGT rs8061723 CTGACTTGCAAAAACA[C/T]AATTAGGTTGAATGGA rs7624432 GAGCTGGAAATAAAGA[AZG]CAATCATTTGAATCAA rs942989 GATCAGATTTACTTAA[A/G]GCTCCATCATCACACA rs7746351 GCATGCAATTGTAGAG[A/T]CTAGGACACTTGGTGA rs7781264 GCCTAGTAGTCAAGCA[C/T]AGTTCTACCCTCCAGC rs869346 GCTTTGGTGGGAAATA[C/T]GATCAGGACTGAGACC rs41503549 AGTTCAGACTGTACTC[C/T]CCCACTATCAATTCAG rs2862907 GTGCCAAAAATCTAGA[C/T]GATGTGCTGCTTTCTT rsll931592 AGAGTCCAAAGCTCCA[G/T]GTTAGAGGCTGGAAGT rs41420549 AGGAAGATGTGTTATT[A/T]AACCAGGTAGTCCCTC rs41465546 ATCCTAGAGAGACAAA[A/G]CAGAGTGAGCCAGTGG rs41454946 ATCCTGCAAGGATTCA[A/G]GATAGTTTTACCAATA rs41388648 ATGAAAAACGTTTGAAIC/GJTTAATCATAGTTGAAG rs41521644 ATGGTTCAGACTAACA[C/T]TGGTGGTGATATTAAC rs41509548 CAGGTTGAGTTCCCAT[C/T]AGGATTTTGACATGAA rs406333 GATGTATGTACATTTC[C/T]AATTTCACCTTTTCAC rs41338847 GCACAACTGATTTTCA[G/T]CCTCAGAAAGAGAAGT rs41391845 AAGAAATCTAAATGAC[C/T]GGCTCTCCCCTCACTT rs41435651 ACCCATGTπTGTTAA[A/G]GTCATTTTGGGCCATG rs41530345 GAAGCTATTAGTTTTA[C/T]GCCACTTCATAGAGAG rs41494550 TTTAAGGTCTG AACTG [A/G] AG AAGAG AAGAG AGG A rs41482845 ACAATATGGTGATAAA[C/G]ATGCATGCATACAGAA

Table 9

GENE_SYMBOL Gene Name

A2M alpha-2-macroglobulin

ABCA1 atp-binding cassette, sub-family a (abc1 ), member 1

ABCB4 atp-binding cassette, sub-family b (mdr/tap), member 4

ABCC4 atp-binding cassette, sub-family c (cftr/mrp), member 4

ABI2 abl interactor 2

ACAA2 acetyl-coenzyme a acyltransferase 2 (mitochondrial 3-oxoacyl-coenzyme a thiolase)

ACBD3 acyl-coenzyme a binding domain containing 3

ACCN1 amiloride-sensitive cation channel 1 , neuronal (degenerin)

AC01 aconitase 1 , soluble

ACTR1A arp1 actin-related protein 1 homolog a, centractin alpha (yeast)

ACVR1 B activin a receptor, type ib

ADAMTS12 adam metallopeptidase with thrombospondin type 1 motif, 12

ADAMTS 14 adam metallopeptidase with thrombospondin type 1 motif, 14

ADAMTS 17 adam metallopeptidase with thrombospondin type 1 motif, 17

ADAMTS9 adam metallopeptidase with thrombospondin type 1 motif, 9

ADAMTSL1 adamts-like 1 o ADCY3 adenylate cyclase 3

ADIP0R2 adiponectin receptor 2

AJAP1 adherens junction associated protein 1

ALDH1A1 aldehyde dehydrogenase 1 family, member a1

ALDH8A1 aldehyde dehydrogenase 8 family, member a1

ALKBH5 alkb, alkylation repair homolog 5 (e. coli)

AMPD1 adenosine monophosphate deaminase 1 (isoform m)

AMPD3 adenosine monophosphate deaminase (isoform e)

ANKRD44 ankyrin repeat domain 44

AOAH acyloxyacyl hydrolase (neutrophil)

APBA1 amyloid beta (a4) precursor protein-binding, family a, member 1 (x11)

APBB2 amyloid beta (a4) precursor protein-binding, family b, member 2 (fe65-like)

ARHGAP22 rho gtpase activating protein 22

ARHGAP24 rho gtpase activating protein 24

ARHGAP25 rho gtpase activating protein 25

ARHGAP26 rho gtpase activating protein 26

ARHGAP29 rho gtpase activating protein 29

ARHGEF19 rho guanine nucleotide exchange factor (gef) 19

ARL15 adp-ribosylation factor-like 15

ART1 adp-ribosyltransferase 1

ASRGL1 asparaginase like 1

ASTN2 astrotactin 2

ASXL2 additional sex combs like 2 (drosophila)

ATP2B4 atpase, ca++ transporting, plasma membrane 4

ATRNL1 attractin-like 1

AVEN apoptosis, caspase activation inhibitor

B3GNT9 UDP-GlcNAc:betaGal beta-1 ,3-N-acetylglucosaminyltransferase 9

BAALC brain and acute leukemia, cytoplasmic

BCAS1 breast carcinoma amplified sequence 1

BET1 bet1 homolog (s. cerevisiae)

BIN2 bridging integrator 2

BLVRA biliverdin reductase a

BNC2 basonuclin 2

C10orf129 chromosome 10 open reading frame 129

C10orf28 chromosome 10 open reading frame 28

C10orf53 chromosome 10 open reading frame 53

C10orf58 chromosome 10 open reading frame 58

C10orf81 chromosome 10 open reading frame 81 o C12orf35 hypothetical protein flj20696

C15orf57 chromosome 15 open reading frame 57

C16orf62 esophageal cancer associated protein

C16orf70 lin-10 homolog (c. elegans)

C17orf57 chromosome 17 open reading frame 57

C1orf129 chromosome 1 open reading frame 129

C2orf34 chromosome 2 open reading frame 34

C2orf82 chromosome 2 open reading frame 82

C3orf44 chromosome 3 open reading frame 44

C3orf59 chromosome 3 open reading frame 59

C4BPB complement component 4 binding protein, beta

C7orf44 hypothetical protein flj10803

CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1

CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta 3 subunit

CADPS ca2+-dependent secretion activator

CACHD1 cache domain containing 1

CAMTA1 calmodulin binding transcription activator 1

CAP2 cap, adenylate cyclase-associated protein, 2 (yeast)

CAPN2 calpain 2, (m/ii) large subunit

CASC5 cancer susceptibility candidate 5

CATSPER2 cation channel, sperm associated 2

CBFB core-binding factor, beta subunit

CCBE1 collagen and calcium binding egf domains 1

CCDC123 hypothetical protein flj14640

CCDC131 kiaaO546 protein

CCDC144B hypothetical protein flj36492

CCDC147 chromosome 10 open reading frame 80

CDH13 cadherin 13, h-cadhehn (heart)

CDH5 cadherin 5, type 2, ve-cadherin (vascular epithelium)

CDH6 cadherin 6, type 2, k-cadhehn (fetal kidney)

CDH8 cadherin 8, type 2

CECR7 cat eye syndrome chromosome region, candidate 7

CENPC1 centromere protein c 1

CENPO hypothetical protein rngd 1266

CEP290 centrosomal protein 290 kda

CLCA1 chloride channel, calcium activated, family member 1

CLSTN2 calsyntenin 2

CMIP c-maf-inducing protein o CNBD1 cyclic nucleotide binding domain containing 1

CNKSR3 cnksr family member 3

CNTN1 contactin 1

CNTN5 neural adhesion molecule

CNTNAP5 contactin associated protein-like 5

COL22A1 collagen, type xxii, alpha 1

COL27A1 hypothetical protein flj11895

COL6A3 collagen, type vi, alpha 3

COX10 cox10 homolog, cytochrome c oxidase assembly protein, heme a: farnesyltransferase (yeast)

CRAMP1 L crm, cramped-like (drosophila)

CSDE1 cold shock domain containing e1 , rna-binding

CSMD3 cub and sushi multiple domains 3

CSRP3 cysteine and glycine-rich protein 3 (cardiac lim protein)

CST7 cystatin f (leukocystatin)

CTAGE5 ctage family, member 5

CTNNA2 catenin (cadherin-associated protein), alpha 2

CTNNA3 catenin (cadherin-associated protein), alpha 3

CTNND2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)

CUGBP2 cug triplet repeat, rna binding protein 2

CUX2 cut-like 2 (drosophila)

CXCL1 chemokine (c-x-c motif) ligand 1 (melanoma growth stimulating activity, alpha)

CYFIP2 cytoplasmic fmr1 interacting protein 2

CYP27C1 flj16008 protein

CYYR 1 cysteine/tyrosine-hch 1

DACH1 dachshund homolog 1 (drosophila)

DAPK1 death-associated protein kinase 1

DBC1 deleted in bladder cancer 1

DCBLD1 discoidin, cub and led domain containing 1

DCC deleted in colorectal carcinoma

DCLK1 doublecortin and cam kinase-like 1

DDAH1 dimethylarginine dimethylaminohydrolase 1

DDEF2 development and differentiation enhancing factor 2

DDEFL1 development and differentiation enhancing factor-like 1

DENND5B DENN/MADD domain containing 5B

DEPDC2 dep domain containing 2

DIP2C dip2 disco-interacting protein 2 homolog c (drosophila)

DNER delta-notch-like egf repeat-containing transmembrane

DOCK2 dedicator of cytokinesis 2

O DOCK8 dedicator of cytokinesis 8

DOK6 docking protein 6

DPP6 dipeptidyl-peptidase 6

DPYSL5 dihydropyrimidinase-like 5

DTD 1 histidyl-tma synthetase 2

DTNB dystrobrevin, beta

DUSP15 dual specificity phosphatase 15

DYDC1 dpy30 domain containing 1

DYDC2 hypothetical protein mgc16186

DYM dymeclin

EDIL3 egf-like repeats and discoidin i-like domains 3

EFHC1 hypothetical protein flj10466

EGFR epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

EGLN1 egl nine homolog 1 (c. elegans)

EHBP1 eh domain binding protein 1

EIF2C2 eukaryotic translation initiation factor 2c, 2

ELA VL3 elav (embryonic lethal, abnormal vision, drosophila)-like 3 (hu antigen c)

ELMO1 engulfment and cell motility 1

EMP2 epithelial membrane protein 2

EN0X1 proliferation-inducing protein 38

EPHA6 eph receptor a6

ERBB2IP erbb2 interacting protein

ERC2 caz-associated structural protein

EVC2 ellis van creveld syndrome 2 (limbin)

EY A2 eyes absent homolog 2 (drosophila)

F5 coagulation factor v (proaccelerin, labile factor)

FAM113B family with sequence similarity 113, member b

FAM19A1 family with sequence similarity 19 (chemokine (c-c motif)-like), member a1

FAM19A2 family with sequence similarity 19 (chemokine (c-c motif)-like), member a2

FANCC fanconi anemia, complementation group c

FBXL7 f-box and leucine-rich repeat protein 7

FBXO39 f-box protein 39

FBXW4 f-box and wd-40 domain protein 4

FCAMR fc receptor, iga, igm, high affinity

FGGY FGGY carbohydrate kinase domain containing

FIGLA factor in the germline alpha

FU27365 flj27365 protein

FLJ42875 hypothetical protein dkfzp761 gO122

FLJ42986 flj42986 protein

FLJ45455 flj45455 protein

FWIN2 formin 2

FOXJ3 forkhead box j3

FREM1 frasi related extracellular matrix 1

FRMD3 ferm domain containing 3

FRMD4A ferm domain containing 4a

FRS2 fibroblast growth factor receptor substrate 2

FSTL4 follistatin-like 4

FTSJD2 FtsJ methyltransferase domain containing 2

FUT9 fucosyltransferase 9 (alpha (1 ,3) fucosyltransferase)

FYCO1 fyve and coiled-coil domain containing 1

FYN fyn oncogene related to src, fgr, yes

GABRB2 gamma-aminobutyric acid (gaba) a receptor, beta 2

GALNT10 udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 10 (galπac-t10)

GALNT13 udp-n-acetyl-alpha-d-galactosamineipolypeptide n-acetylgalactosaminyltransferase 13 (galnac-t13)

GALNT5 udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 5 (galnac-t5)

GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

GATAD2A gata zinc finger domain containing 2a

GGTA1 glycoprotein, alpha-galactosyltransferase 1

GLDC glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein p)

GMDS gdp-mannose 4,6-dehydratase

GNA14 guanine nucleotide binding protein (g protein), alpha 14

GNG7 guanine nucleotide binding protein (g protein), gamma 7

GPC5 glypican 5

GPC6 glypican 6

GPD1 L glycerol-3-phosphate dehydrogenase 1-like

GPM6A glycoprotein m6a

GPR103 g protein-coupled receptor 103

GPR116 g protein-coupled receptor 116

GPR176 g protein-coupled receptor 176

GPR37L1 g protein-coupled receptor 37 like 1

GRB2 growth factor receptor-bound protein 2

GRIA1 glutamate receptor, ionotropic, ampa 1

GRIK3 glutamate receptor, ionotropic, kainate 3

GRIN2A glutamate receptor, ionotropic, n-methyl d-aspartate 2a

GRM4 glutamate receptor, metabotropic 4

GRM8 glutamate receptor, metabotropic 8

GSTZ1 glutathione transferase zeta 1 (maleylacetoacetate isomerase)

GUCY1 A2 guanylate cyclase 1 , soluble, alpha 2

HBG2 hemoglobin, gamma a

HCN 1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1

HELLS helicase, lymphoid-specific

HEPACAM2 HEPACAM family member 2

HHAT hedgehog acyltransferase

HISPPD2A histidine acid phosphatase domain containing 2a

HIVEP3 human immunodeficiency virus type i enhancer binding protein 3

HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1

HMCN1 hemicentin 1

HMGA2 high mobility group at-hook 2

HOOK1 hook homolog 1 (drosophila)

HS3ST4 heparan sulfate (glucosamine) 3-o-sulfotransferase 4

HYDIN hydrocephalus inducing

CHRM2 cholinergic receptor, muscarinic 2

CHRM3 cholinergic receptor, muscarinic 3

CHST11 carbohydrate (chondroitin 4) sulfotransferase 11

CHST12 carbohydrate (chondroitin 4) sulfotransferase 12

CHST8 carbohydrate (n-acetylgalactosamine 4-0) sulfotransferase 8

IHPK3 inositol hexaphosphate kinase 3

IL15RA interleukin 15 receptor, alpha

IL17RA interleukin 17 receptor

IL23R interleukin 23 receptor

IL4R interleukin 4 receptor

INPP4B inositol polyphosphate-4-phosphatase, type ii, 105kda

INPP5A inositol polyphosphate-5-phosphatase, 40kda

IQCA1 IQ motif containing with AAA domain 1

IREB2 iron-responsive element binding protein 2

ITGA9 iπtegrin, alpha 9

JPH2 junctophilin 2

KCNH8 potassium voltage-gated channel, subfamily h (eag-related), member 8

KCNQ5 potassium voltage-gated channel, kqt-like subfamily, member 5

KCTD9 potassium channel tetramerisation domain containing 9

KHDRBS2 kh domain containing, rna binding, signal transduction associated 2

KIAA0319 kiaaO319

KIAA0774 kiaaO774

KIAA0892 kiaaO892

KIAA0999 kiaaO999 protein

KIAA1430 kiaa1430

KITLG kit ligand

KLHL29 hypothetical protein flj14106

KLHL3 kelch-like 3 (drosophila)

LACTB2 lactamase, beta 2

LAD1 ladinin 1

LAMB4 laminin, beta 4

LARGE like-glycosyltransferase

LARS leucyl-trna synthetase

LDLRAD3 low density lipoprotein receptor class a domain containing 3

LEPR leptin receptor

LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase

LIMS1 Nm and senescent cell antigen-like domains 1

LIN7A lin-7 homolog a (c. elegans)

LOC100131081 hypothetical protein LOC100131081

LOC284422 similar to hspc323

LOC730351 hypothetical protein LOC730351

LOX lysyl oxidase

L0XL2 lysyl oxidase-like 2

LRP1 B low density lipoprotein-related protein 1 b (deleted in tumors)

LRRC27 leucine rich repeat containing 27

LRRC4C leucine rich repeat containing 4c

LRRIQ1 leucine-rich repeats and iq motif containing 1

LSAMP limbic system-associated membrane protein

LTF lactotransferrin

LY75 lymphocyte antigen 75

LYCAT lysocardiolipin acyltransferase

MACROD2 chromosome 20 open reading frame 133

MAD1 L1 mad1 mitotic arrest deficient-like 1 (yeast)

MAGH membrane associated guanylate kinase, ww and pdz domain containing 1

MAGI2 membrane associated guanylate kinase, ww and pdz domain containing 2

MAMDC2 mam domain containing 2

MARK1 map/microtubule affinity-regulating kinase 1

MAT1 A methionine adenosyltransferase i, alpha

MBD5 methyl-cpg binding domain protein 5

MBNL2 muscleblind-like 2 (drosophila)

MBOAT1 o-acyltransferase (membrane bound) domain containing 1

4- MDGA2 mam domain containing 1

MDM4 mdm4, transformed 3t3 cell double minute 4, p53 binding protein (mouse)

MFSD1 major facilitator superfamily domain containing 1

MGAM maltase-glucoamylase (alpha-glucosidase)

MGC16169 hypothetical protein mgc16169

MGC16703 alpha tubulin-like

MIA3 kiaaO268 protein

MLF1 myeloid leukemia factor 1

MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, drosophila); translocated to, 3

MMP16 matrix metallopeptidase 16 (membrane-inserted)

MMP2 matrix metallopeptidase 2 (gelatinase a, 72kda gelatinase, 72kda type iv collagenase)

MOBKL1 A mob1 , mps one binder kinase activator-like 1a (yeast)

MOBKL2B mob1 , mps one binder kinase activator-like 2b (yeast)

MPHOSPH6 m-phase phosphoprotein 6

MPRIP myosin phosphatase Rho interacting protein

MTMR14 chromosome 3 open reading frame 29

MUC17 mucin 17

MYH6 myosin, heavy polypeptide 6, cardiac muscle, alpha (cardiomyopathy, hypertrophic 1)

MYH7 myosin, heavy polypeptide 7, cardiac muscle, beta

MY018B myosin xviiib

MYT1 myelin transcription factor 1

MYT1 L myelin transcription factor 1 -like

NAALADL2 n-acetylated alpha-linked acidic dipeptidase-like 2

NAGK n-acetylglucosamine kinase

NAP5 nck-associated protein 5

NCK2 nek adaptor protein 2

NC0A1 nuclear receptor coactivator 1

NEBL nebulette

NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like

NELL1 nel-like 1 (chicken)

NKAIN2 t-cell lymphoma breakpoint associated target 1

NMT1 n-myristoyltransferase 1

NPAS3 neuronal pas domain protein 3

NRCAM neuronal cell adhesion molecule

NRG3 neuregulin 3

NRXN3 neurexin 3

NT5DC3 5'-nucleotidase domain containing 3

NUDT1 nudix (nucleoside diphosphate linked moiety x)-type motif 1

Ul NVL nuclear vcp-like

OAF oaf homolog (drosophila)

OPCWIL opioid binding protein/cell adhesion molecule-like

0PN5 opsin 5

OR2L2 olfactory receptor, family 2, subfamily I, member 2

0R51 L1 olfactory receptor, family 51 , subfamily I, member 1

OSBPL10 hypothetical protein flj20363

0SBPL1A oxysterol-binding protein-related protein 1

0SBPL8 oxysterol binding protein-like 8

PACRG park2 co-regulated

PACS1 phosphofurin acidic cluster sorting protein 1

PAFAH1 B2 platelet-activating factor acetylhydrolase, isoform ib, beta subunit 30kda

PAPPA pregnancy-associated plasma protein a, pappalysin 1

PARK2 parkinson disease (autosomal recessive, juvenile) 2, parkin

PASK pas domain containing serine/threonine kinase

PCDH15 protocadherin 15

PCNP pest-containing nuclear protein

PDE4D phosphodiesterase 4d, camp-specific (phosphodiesterase e3 dunce homolog, drosophila)

PDE9A phosphodiesterase 9a

PDILT protein disulfide isomerase-like protein of the testis

PFKM phosphofructokinase, muscle

PGM1 phosphoglucomutase 1

PHF3 kiaaO244 protein

PION pigeon homolog (Drosophila)

PKD1 L2 polycystic kidney disease 1 -like 2

PLAC8L1 plac8-like 1

PLCG2 phospholipase c, gamma 2 (phosphatidylinositol-specific)

PLCL2 phospholipase c-like 2

PLCZ1 phospholipase c, zeta 1

PLD1 phospholipase d1 , phosphatidylcholine-specific

PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7

PLEKHH1 pleckstrin homology domain containing, family h (with myth4 domain) member 1

P0U6F1 pou domain, class 6, transcription factor 1

PPARGC1 A peroxisome proliferative activated receptor, gamma, coactivator 1 , alpha

PPIC peptidylprolyl isomerase c (cyclophilin c)

PPP1 R13B protein phosphatase 1 , regulatory (inhibitor) subunit 13b

PPP1 R9A protein phosphatase 1 , regulatory (inhibitor) subunit 9a

PPP2R2A protein phosphatase 2 (formerly 2a), regulatory subunit b (pr 52), alpha isoform

PPP2R5C protein phosphatase 2, regulatory subunit b (b56), gamma isoform

PREX1 phosphatidylinositol 3,4,5-thsphosphate-dependent rac exchanger 1

PRKACB protein kinase, camp-dependent, catalytic, beta

PRKCE protein kinase c, epsilon

PRKCQ protein kinase c, theta

PRPF40A huntingtin-interacting protein a

PSD3 pleckstrin and sec7 domain containing 3

PTBP2 polypyrimidine tract binding protein 2

PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enhched)

PTPRG protein tyrosine phosphatase, receptor type, g

PTPRM protein tyrosine phosphatase, receptor type, m

PTPRT protein tyrosine phosphatase, receptor type, t

PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator c; nectin)

PZP pregnancy-zone protein

RAB11 FIP5 rab11 family interacting protein 5 (class i)

RAB2A rab2, member ras oncogene family

RAD18 rad18 homolog (s. cerevisiae)

RAD50 rad50 homolog (s. cerevisiae)

RAH retinoic acid induced 1

RB1 retinoblastoma 1 (including osteosarcoma)

RCBTB2 regulator of chromosome condensation (red ) and btb (poz) domain containing protein 2

RFWD2 ring finger and wd repeat domain 2

RFX3 regulatory factor x, 3 (influences hla class ii expression)

RHOG ras homolog gene family, member g (rho g)

RIMBP2 rims binding protein 2

R0R2 receptor tyrosine kinase-like orphan receptor 2

RORA rar-related orphan receptor a

RP1-21 O18.1 kazrin

RP1-21O18.1 hypothetical protein flj43806

RPUSD2 ma pseudouridylate synthase domain containing 2

RUNX1 runt-related transcription factor 1 (acute myeloid leukemia 1 ; aml1 oncogene)

RUNX1T1 runt-related transcription factor 1 ; translocated to, 1 (cyclin d-related)

RYR2 ryanodine receptor 2 (cardiac)

SASH1 sam and sh3 domain containing 1

SCAPER zinc finger protein 291

SCGB2A2 secretoglobin, family 2a, member 2

SCN2A sodium channel, voltage-gated, type ii, alpha 2

SDK1 sidekick homolog 1 (chicken)

SELP selectin p (granule membrane protein 140kda, antigen cd62)

SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), (semaphohn) 5a

SEMA6D kiaa1479 protein

SENP7 sumoi/sentrin specific peptidase 7

SFXN5 sideroflexin 5

SGCD sarcoglycan, delta (35kda dystrophin-associated glycoprotein)

SGCZ sarcoglycan zeta

SH3PXD2A sh3 and px domains 2a

SH3RF2 sh3 domain containing ring finger 2

SHPK sedoheptulokinase

SCHIP1 schwannomin interacting protein 1

SKAP1 src family associated phosphoprotein 1

SLAMF9 slam family member 9

SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3

SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31

SLC35F4 solute carrier family 35, member f4

SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8

SLC7A14 solute carrier family 7 (cationic amino acid transporter, y+ system), member 14

SLC7A8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8

SMAD9 smad, mothers against dpp homolog 9 (drosophila)

SNAP25 synaptosomal-associated protein, 25kda

SNX24 sorting nexing 24

SNX25 sorting nexin 25

SNX31 sorting nexin 31

S0RBS2 sorbin and sh3 domain containing 2

S0RCS1 sortilin-related vps10 domain containing receptor 1

S0RCS2 sortilin-related vps10 domain containing receptor 2

SPARC secreted protein, acidic, cysteine-rich (osteonectin)

SPEF2 kpl2 protein

SPNS2 hypothetical protein lod 24976

SP0CK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

SPTLC3 chromosome 20 open reading frame 38

SRFBP1 serum response factor binding protein 1

SSR1 signal sequence receptor, alpha (translocon-associated protein alpha)

STK17A serine/threonine kinase 17a (apoptosis-inducing)

STK39 serine threonine kinase 39 (ste20/sps1 homolog, yeast)

STOX2 storkhead box 2

STRC stereocilin

STRN striatin, calmodulin binding protein

STX8 syntaxin 8

SULF1 sulfatase 1

SULF2 sulfatase 2

SVEP1 sushi, von willebrand factor type a, egf and pentraxin domain containing 1

SYK spleen tyrosine kinase

SYNPO2L synaptopodin 2-like

SYT9 synaptotagmin ix

TACC2 transforming, acidic coiled-coil containing protein 2

TAOK3 tao kinase 3

TCF4 transcription factor 4

TCF7L2 transcription factor 7-like 2 (t-cell specific, hmg-box)

TCP1 t-complex 1

TEK tek tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)

THRB thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)

THSD4 thrombospondin, type i, domain containing 4

TIAM 1 t-cell lymphoma invasion and metastasis 1

TMCC1 transmembrane and coiled-coil domain family 1

TMEM132D transmembrane protein 132d

TMEM16F transmembrane protein 16f

TMEM63A transmembrane protein 63a

TM0D1 tropomodulin 1

TMPRSS13 transmembrane protease, serine 13

TMPRSS2 transmembrane protease, serine 2

TNFRSF1 B tumor necrosis factor receptor superfamily, member 1 b

TOX thymus high mobility group box protein tox

TP53BP1 tumor protein p53 binding protein, 1

TP63 tumor protein p73-like

TRAK1 trafficking protein, kinesin binding 1

TRAM1 translocation associated membrane protein 1

TRAM2 translocation associated membrane protein 2

TRDN triadin

TRPC4 transient receptor potential cation channel, subfamily c, member 4

TRPM8 transient receptor potential cation channel, subfamily m, member 8

TRPV1 transient receptor potential cation channel, subfamily v, member 1

TSNARE1 t-snare domain containing 1

TTBK2 kiaaO847 protein

TTC39B tetratricopeptide repeat domain 39B

UBASH3B cbl-interacting protein sts-1

UCK2 uridine-cytidine kinase 2

UHRF1 ubiquitin-like, containing phd and ring finger domains, 1

UNC5C unc-5 homolog c (c. elegans)

USH2A usher syndrome 2a (autosomal recessive, mild)

VAV3 vav 3 oncogene

VGLL4 vestigial like 4 (drosophila)

VPS13B cohen syndrome 1

VPS54 vacuolar protein sorting 54 (yeast)

VPS8 kiaa0804

WDR19 wd repeat domain 19

WDR70 wd repeat domain 70

WIPI2 wd repeat domain, phosphoinositide interacting 2

WTAP wilms tumor 1 associated protein

WWOX putative oxidoreductase

ZBTB16 zinc finger and btb domain containing 16

ZBTB20 zinc finger and btb domain containing 20

ZC3H4 chromosome 19 open reading frame 7

ZCCHC7 zinc finger, cchc domain containing 7

ZFAT zinc finger and AT hook domain containing

ZFYVE19 zinc finger, fyve domain containing 19

ZNF236 zinc finger protein 236

ZNF256 zinc finger protein 256

ZNF407 zinc finger protein 407

ZNF606 zinc finger protein 606

ZNF700 zinc finger protein 700

ZNF831 zinc finger protein 831

ZSCAN29 zinc finαer Drotein 690

K)

O

Table 10

METHOD

ASSOCIATION

RS ID MARSHFIELD TYPE COVARIATES PHENOTYPE CHR P-VALUE rs1193167 15.48 linear regression Creatinine Clearance at entry 1 7.47E-05 rs1193167 15.48 linear regression GE Creatinine Clearance at entry 1 8.00E-05 rs11121667 23.49 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 1 1.91 E-04 rs11121667 23.49 linear regression AGE, SEX Creatinine Clearance at entry 1 3.22E-04 rs11121778 25.07 linear regression GE Albumin/Creatinine ratio at entry 1 1.93E-04 rs11121778 25.07 linear regression Albumin/Creatinine ratio at entry 1 2.14E-04 rs11121778 25.07 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 2.80E-04 rs11121778 25.07 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 1 2.81 E-04 rs6586496 36.52 linear regression AGE, SEX Creatinine Clearance at entry 1 2.98E-04 rs6586496 36.52 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 3.50E-04 rs905909 56.52 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 1.50E-04 rs905909 56.52 linear regression AGE, SEX Creatinine Clearance at entry 1 1.93E-04 as rs9508 56.53 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 1 2.13E-04

^ rs9508 56.53 linear regression AGE, SEX Creatinine Clearance at entry 1 2.89E-04 rs576550 56.53 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 1 4.85E-04 rs7532379 56.53 linear regression AGE, SEX Creatinine Clearance at entry 1 3.42E-04 rs7532379 56.53 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 1 3.97E-04 rs11247766 56.53 linear regression AGE, SEX Creatinine Clearance at entry 1 2.72E-04 rs11247766 56.53 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 1 3.06E-04 rs4652974 62.39 linear regression GE Creatinine Clearance at entry 1 1.09E-04 rs4652974 62.39 linear regression Creatinine Clearance at entry 1 1.13E-04 rs4652974 62.39 linear regression AGE ₁ SEX Creatinine Clearance at entry 1 3.80E-04 rs10914782 62.41 linear regression Creatinine Clearance at entry 1 4.56E-04 rs10914782 62.41 linear regression GE Creatinine Clearance at entry 1 4.68E-04 rs1886637 62.41 linear regression Creatinine Clearance at entry 1 2.78E-04 rs1886637 62.41 linear regression GE Creatinine Clearance at entry 1 2.88E-04 rs3845476 62.42 linear regression AGE ₁ SEX Creatinine Clearance at entry 1 9.71 E-06 rs3845476 62.42 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 1.91 E-05 rs3845476 62.42 linear regression GE Creatinine Clearance at entry 1 8.85E-05 rs3845476 62.42 linear regression Creatinine Clearance at entry 1 9.38E-05 rs3842834 62.42 linear regression AGE ₁ SEX Creatinine Clearance at entry 1 1.13E-05

rs3842834 62.42 linear regression AGE, SEX, GE Creatinine Clearance at entry 2.14E-05 rs3842834 62.42 linear regression GE Creatinine Clearance at entry 1.09E-04 rs3842834 62.42 linear regression Creatinine Clearance at entry 1.16E-04 rs12062730 62.43 linear regression AGE, SEX Creatinine Clearance at entry 2.47E-05 rs12062730 62.43 linear regression AGE, SEX, GE Creatinine Clearance at entry 4.56E-05 rs12062730 62.43 linear regression GE Creatinine Clearance at entry 3.79E-04 rs12062730 62.43 linear regression Creatinine Clearance at entry 3.94E-04 rs12067054 62.43 linear regression AGE, SEX Creatinine Clearance at entry 3.25E-05 rs12067054 62.43 linear regression AGE, SEX, GE Creatinine Clearance at entry 5.99E-05 rs12067054 62.43 linear regression GE Creatinine Clearance at entry 4.35E-04 rs12067054 62.43 linear regression Creatinine Clearance at entry 4.52E-04 rs10753290 62.43 linear regression AGE, SEX Creatinine Clearance at entry 4.15E-06 rs10753290 62.43 linear regression AGE, SEX, GE Creatinine Clearance at entry 8.30E-06 rs10753290 62.43 linear regression GE Creatinine Clearance at entry 1.80E-05 rs10753290 62.43 linear regression Creatinine Clearance at entry 2.06E-05 rs3845477 62.43 linear regression AGE, SEX Creatinine Clearance at entry 3.25E-05 rs3845477 62.43 linear regression AGE, SEX, GE Creatinine Clearance at entry 5.99E-05 rs3845477 62.43 linear regression GE Creatinine Clearance at entry 4.35E-04 κ> rs3845477 62.43 linear regression Creatinine Clearance at entry 4.52E-04 rs1570092 62.43 linear regression AGE, SEX Creatinine Clearance at entry 2.11 E-06 rs1570092 62.43 linear regression AGE, SEX, GE Creatinine Clearance at entry 4.17E-06 rs1570092 62.43 linear regression GE Creatinine Clearance at entry 1.25E-05 rs1570092 62.43 linear regression Creatinine Clearance at entry 1.42E-05 rs911213 62.43 linear regression AGE, SEX Creatinine Clearance at entry 2.24E-06 rs911213 62.43 linear regression AGE, SEX, GE Creatinine Clearance at entry 4.40E-06 rs911213 62.43 linear regression GE Creatinine Clearance at entry 1.30E-05 rs911213 62.43 linear regression Creatinine Clearance at entry 1.48E-05 rs911214 62.43 linear regression AGE, SEX Creatinine Clearance at entry 2.19E-06 rs911214 62.43 linear regression AGE, SEX, GE Creatinine Clearance at entry 4.34E-06 rs911214 62.43 linear regression GE Creatinine Clearance at entry 1.13E-05 rs911214 62.43 linear regression Creatinine Clearance at entry 1.29E-05 rs10753291 62.43 linear regression AGE, SEX Creatinine Clearance at entry 2.11 E-06 rs10753291 62.43 linear regression AGE, SEX, GE Creatinine Clearance at entry 4.17E-06 rs10753291 62.43 linear regression GE Creatinine Clearance at entry 1.25E-05 rs10753291 62.43 linear regression Creatinine Clearance at entry 1.42E-05 rs10914789 62.43 linear regression GE Creatinine Clearance at entry 1.84E-04

rs10914789 62.43 linear regression Creatinine Clearance at entry 1 1.88E-04 rs10914789 62.43 linear regression AGE ₁ SEX Creatinine Clearance at entry 1 2.12E-04 rs10914789 62.43 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 2.77E-04 rs6425846 62.44 linear regression AGE, SEX Creatinine Clearance at entry 1 2.28E-06 rs6425846 62.44 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 4.48E-06 rs6425846 62.44 linear regression GE Creatinine Clearance at entry 1 1.40E-05 rs6425846 62.44 linear regression Creatinine Clearance at entry 1 1.58E-05 rs6425847 62.44 linear regression AGE ₁ SEX Creatinine Clearance at entry 1 2.18E-06 rs6425847 62.44 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 1 4.37E-06 rs6425847 62.44 linear regression GE Creatinine Clearance at entry 1 9.50E-06 rs6425847 62.44 linear regression Creatinine Clearance at entry 1 1.08E-05 rs746667 62.45 linear regression AGE, SEX Creatinine Clearance at entry 1 2.56E-06 rs746667 62.45 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 1 4.34E-06 rs746667 62.45 linear regression GE Creatinine Clearance at entry 1 1.05E-05 rs746667 62.45 linear regression Creatinine Clearance at entry 1 1.16E-05 rs1321627 62.46 linear regression AGE, SEX Creatinine Clearance at entry 1 5.75E-06 rs1321627 62.46 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 7.25E-06 rs1321627 62.46 linear regression GE Creatinine Clearance at entry 1 5.34E-05 rs1321627 62.46 linear regression Creatinine Clearance at entry 1 5.74E-05 rs7530700 62.91 linear regression AGE, SEX Creatinine Clearance at entry 1 3.74E-04 rs12138639 62.91 linear regression AGE, SEX Creatinine Clearance at entry 1 3.38E-04 rs12138639 62.91 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 4.72E-04 rs7531813 65.23 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 1 1.21 E-04 rs7531813 65.23 linear regression Albumin/Creatinine ratio at entry 1 1.88E-04 rs7531813 65.23 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 1 2.28E-04 rs7531813 65.23 linear regression GE Albumin/Creatinine ratio at entry 1 3.37E-04 rs11206897 70.52 linear regression GE Albumin/Creatinine ratio at entry 1 1.26E-04 rs11206897 70.52 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 1 1.38E-04 rs11206897 70.52 linear regression Albumin/Creatinine ratio at entry 1 1.55E-04 rs11206897 70.52 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 1.79E-04 rs349447 71.77 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 1 1.86E-04 rs349447 71.77 linear regression GE Albumin/Creatinine ratio at entry 1 2.38E-04 rs16831558 72.97 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 1 2.26E-04 rs16831558 72.97 linear regression GE Albumin/Creatinine ratio at entry 1 2.93E-04 rs16831558 72.97 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 3.40E-04 rs16831558 72.97 linear regression Albumin/Creatinine ratio at entry 1 3.86E-04

rs232892 87.11 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 4.95E-04 rs7515512 94.67 linear regression GE Creatinine Clearance at entry 1 1.02E-04 rs7515512 94.67 linear regression Creatinine Clearance at entry 1 1.24E-04 rs7515512 94.67 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 3.33E-04 rs7515512 94.67 linear regression AGE, SEX Creatinine Clearance at entry 1 3.85E-04 rs2095403 95.47 linear regression AGE, SEX Creatinine Clearance at entry 1 4.80E-04 rs10789252 99.55 linear regression Creatinine Clearance at entry 1 3.16E-04 rs10789252 99.55 linear regression GE Creatinine Clearance at entry 1 3.27E-04 rs2419044 99.55 linear regression Creatinine Clearance at entry 1 1.96E-04 rs2419044 99.55 linear regression GE Creatinine Clearance at entry 1 2.04E-04 rs12030775 99.55 linear regression Creatinine Clearance at entry 1 4.78E-04 rs12030775 99.55 linear regression GE Creatinine Clearance at entry 1 4.81 E-04 rs1926282 99.55 linear regression GE Creatinine Clearance at entry 1 2.27E-04 rs1926282 99.55 linear regression Creatinine Clearance at entry 1 2.32E-04 rs12042011 107.55 linear regression GE Creatinine Clearance at entry 1 2.48E-04 rs12042011 107.55 linear regression Creatinine Clearance at entry 1 2.59E-04 rs1361196 113.14 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 3.42E-04 o, rs1361196 113.14 linear regression Albumin/Creatinine ratio at entry 1 4.81 E-04

*. rs1416079 113.14 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 1 3.16E-04 rs1416079 113.14 linear regression Albumin/Creatinine ratio at entry 1 4.55E-04 rs1416078 113.14 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 3.60E-04 rs6673199 127.46 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 1 6.26E-08 rs6673199 127.46 linear regression GE Albumin/Creatinine ratio at entry 1 6.70E-08 rs6673199 127.46 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 1.05E-07 rs6673199 127.46 linear regression Albumin/Creatinine ratio at entry 1 1.16E-07 rs17115571 127.48 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 1 1.45E-07 rs17115571 127.48 linear regression GE Albumin/Creatinine ratio at entry 1 1.53E-07 rs17115571 127.48 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 2.34E-07 rs17115571 127.48 linear regression Albumin/Creatinine ratio at entry 1 2.54E-07 rs2391782 127.59 linear regression GE Albumin/Creatinine ratio at entry 1 1.63E-07 rs2391782 127.59 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 1 1.92E-07 rs2391782 127.59 linear regression Albumin/Creatinine ratio at entry 1 2.71 E-07 rs2391782 127.59 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 2.94E-07 rs924277 148.78 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 4.32E-04 rs4313394 166.34 linear regression Creatinine Clearance at entry 1 3.39E-04 rs4313394 166.34 linear regression GE Creatinine Clearance at entry 1 3.56E-04

rs7535475 170.19 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 1 4.10E-04 rs7512140 170.19 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 1 2.01 E-04 rs7512140 170.19 linear regression GE Albumin/Creatinine ratio at entry 1 2.86E-04 rs6682062 179.53 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 4.34E-04 rs7550698 179.53 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 4.93E-04 rs7518155 179.54 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 4.-55E-04 rs3917851 187.48 linear regression GE Creatinine Clearance at entry 1 9.36E-05 rs3917851 187.48 linear regression Creatinine Clearance at entry 1 9.82E-05 rs3917851 187.48 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 3.63E-04 rs17522707 187.48 linear regression GE Creatinine Clearance at entry 1 3.04E-04 rs17522707 187.48 linear regression Creatinine Clearance at entry 1 3.07E-04 rs3917789 187.49 linear regression GE Creatinine Clearance at entry 1 2.56E-04 rs3917789 187.49 linear regression Creatinine Clearance at entry 1 2.63E-04 rs3917789 187.49 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 4.23E-04 rs3917789 187.49 linear regression AGE, SEX Creatinine Clearance at entry 1 4.25E-04 rs3917788 187.49 linear regression GE Creatinine Clearance at entry 1 1.33E-04 rs3917788 187.49 linear regression Creatinine Clearance at entry 1 1.35E-04 rs17591814 201.44 linear regression AGE, SEX Creatinine Clearance at entry 1 2.33E-04 en rs17591814 201.44 linear regression GE Creatinine Clearance at entry 1 2.73E-04 rs17591814 201.44 linear regression Creatinine Clearance at entry 1 2.82E-04 rs17591814 201.44 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 2.97E-04 rs10465598 207.75 linear regression AGE, SEX Creatinine Clearance at entry 1 3.09E-04 rs12024767 207.76 linear regression AGE, SEX Creatinine Clearance at entry 1 1.46E-04 rs12024767 207.76 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 2.82E-04 rs7527158 207.79 linear regression AGE, SEX Creatinine Clearance at entry 1 1 J5E-04 rs7527158 207.79 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 3.39E-04 rs1854037 207.84 linear regression AGE, SEX Creatinine Clearance at entry 1 1.20E-05 rs1854037 207.84 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 1.73E-05 rs1854037 207.84 linear regression Creatinine Clearance at entry 1 3.57E-04 rs1854037 207.84 linear regression GE Creatinine Clearance at entry 1 3.96E-04 rs12043681 212.25 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 1.21 E-04 rs12043681 212.25 linear regression AGE, SEX Creatinine Clearance at entry 1 1.53E-04 rs1407684 212.25 linear regression AGE, SEX, GE Creatinine Clearance at entry 1 1.22E-04 rs1407684 212.25 linear regression AGE, SEX Creatinine Clearance at entry 1 1.58E-04 rs12119983 221.90 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 4.65E-04 rs677066 222.57 linear regression GE Creatinine Clearance at entry 1 1.86E-04

rs677066 222.57 linear regression Creatinine Clearance at entry 1 2.26E-04 rs6540484 225.48 linear regression AGE, SEX Creatinine Clearance at entry 1 3.57E-04 rs17013025 225.52 linear regression AGE, SEX Creatinine Clearance at entry 1 2.35E-04 rs1419090 230.44 linear regression Creatinine Clearance at entry 1 3.60E-04 rs1419090 230.44 linear regression GE Creatinine Clearance at entry 1 3.65E-04 rs7534285 230.44 linear regression Creatinine Clearance at entry 1 7.48E-05 rs7534285 230.44 linear regression GE Creatinine Clearance at entry 1 7.89E-05 rs4951625 231.40 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 4.01 E-04 rs4951625 231.40 linear regression Albumin/Creatinine ratio at entry 1 4.94E-04 rs1891410 242.56 linear regression GE Albumin/Creatinine ratio at entry 1 3.73E-04 rs1891410 242.56 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 1 4.08E-04 rs1637931 244.01 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 3.89E-04 rs11568046 244.09 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 1 1.10E-04 rs11568046 244.09 linear regression Albumin/Creatinine ratio at entry 1 1.40E-04 rs11568046 244.09 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 1 3.75E-04 rs11568046 244.09 linear regression GE Albumin/Creatinine ratio at entry 1 4.40E-04 rs11122414 244.94 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 1 1.24E-04 rs11122414 244.94 linear regression GE Albumin/Creatinine ratio at entry 1 1.31 E-04 rs11122414 244.94 linear regression Albumin/Creatinine ratio at entry 1 2.68E-04 rs11122414 244.94 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 2.73E-04 rs12403846 248.33 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 1 1.01 E-05 rs12403846 248.33 linear regression GE Albumin/Creatinine ratio at entry 1 2.12E-05 rs12403846 248.33 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 4.70E-05 rs12403846 248.33 linear regression Albumin/Creatinine ratio at entry 1 6.98E-05 rs10465473 248.33 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 1 9.06E-05 rs10465473 248.33 linear regression GE Albumin/Creatinine ratio at entry 1 1.78E-04 rs10465473 248.33 linear regression AGE, SEX Albumin/Creatinine ratio at entry 1 2.77E-04 rs10465473 248.33 linear regression Albumin/Creatinine ratio at entry 1 4.11 E-04 rs1897164 22.36 linear regression AGE, SEX, GE Creatinine Clearance at entry 2 4.80E-04 rs6531246 35.87 linear regression GE Creatinine Clearance at entry 2 2.14E-04 rs6531246 35.87 linear regression Creatinine Clearance at entry 2 2.21 E-04 rs6547953 42.59 linear regression Albumin/Creatinine ratio at entry 2 1.33E-05 rs6547953 42.59 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 1.42E-05 rs6547953 42.59 linear regression GE Albumin/Creatinine ratio at entry 2 3.35E-05 rs6547953 42.59 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 4.05E-05 rs1022377 42.61 linear regression Albumin/Creatinine ratio at entry 2 1.09E-05

rs1022377 42.61 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 2 1.14E-05 rs1022377 42.61 linear regression GE Albumin/Creatinine ratio at entry 2 2.69E-05 rs1022377 42.61 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 2 3.18E-05 rs17725296 42.61 linear regression Albumin/Creatinine ratio at entry 2 2.76E-05 rs17725296 42.61 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 2 3.37E-05 rs17725296 42.61 linear regression GE Albumin/Creatinine ratio at entry 2 7.44E-05 rs17725296 42.61 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 1.06E-04 rs17674649 42.68 linear regression Albumin/Creatinine ratio at entry 2 1.49E-05 rs17674649 42.68 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 2 1.61 E-05 rs17674649 42.68 linear regression GE Albumin/Creatinine ratio at entry 2 3.47E-05 rs17674649 42.68 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 2 4.13E-05 rs2176696 42.68 linear regression Albumin/Creatinine ratio at entry 2 1.13E-05 rs2176696 42.68 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 1.20E-05 rs2176696 42.68 linear regression GE Albumin/Creatinine ratio at entry 2 2.53E-05 rs2176696 42.68 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 2 2.91 E-05 rs1356704 42.69 linear regression Albumin/Creatinine ratio at entry 2 1.47E-05 rs1356704 42.69 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 1.62E-05 rs1356704 42.69 linear regression GE Albumin/Creatinine ratio at entry 2 3.04E-05 rs1356704 42.69 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 2 3.60E-05 rs17791703 44.97 linear regression Creatinine Clearance at entry 2 3.77E-04 rs17791703 44.97 linear regression GE Creatinine Clearance at entry 2 3.83E-04 rs6761875 45.02 linear regression Creatinine Clearance at entry 2 2.07E-04 rs6761875 45.02 linear regression GE Creatinine Clearance at entry 2 2.11 E-04 rs13423976 59.66 linear regression AGE, SEX Creatinine Clearance at entry 2 1.77E-04 rs13423976 59.66 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 2 2.19E-04 rs17568979 72.70 linear regression GE Creatinine Clearance at entry 2 2.67E-04 rs17568979 72.70 linear regression Creatinine Clearance at entry 2 2.71 E-04 rs10490107 78.35 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 2.83E-04 rs10490107 78.35 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 3.07E-04 rs10490107 78.35 linear regression GE Albumin/Creatinine ratio at entry 2 3.07E-04 rs10490107 78.35 linear regression Albumin/Creatinine ratio at entry 2 3.21 E-04 rs13008483 78.45 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 1.97E-04 rs13008483 78.45 linear regression GE Albumin/Creatinine ratio at entry 2 2.19E-04 rs13008483 78.45 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 2.74E-04 rs13008483 78.45 linear regression Albumin/Creatinine ratio at entry 2 2.99E-04 rs13015251 78.45 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 1.65E-04

rs13015251 78.45 linear regression GE Albumin/Creatinine ratio at entry 2 1.83E-04 rs13015251 78.45 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 2.25E-04 rs13015251 78.45 linear regression Albumin/Creatinine ratio at entry 2 2.45E-04 rs11688740 80.03 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 3.77E-05 rs11688740 80.03 linear regression Albumin/Creatinine ratio at entry 2 5.21 E-05 rs11688740 80.03 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 1.20E-04 rs11688740 80.03 linear regression GE Albumin/Creatinine ratio at entry 2 1.52E-04 rs869798 82.72 linear regression GE Creatinine Clearance at entry 2 4.51 E-04 rs869798 82.72 linear regression Creatinine Clearance at entry 2 4.68E-04 rs6713 88.55 linear regression Albumin/Creatinine ratio at entry 2 4.16E-04 rs17011370 94.48 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 3.65E-04 rs17011370 94.48 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 3.91 E-04 rs17011370 94.48 linear regression Albumin/Creatinine ratio at entry 2 4.30E-04 rs17011370 94.48 linear regression GE Albumin/Creatinine ratio at entry 2 4.71 E-04 rs1318563 102.31 linear regression AGE, SEX, GE Creatinine Clearance at entry 2 2.74E-04 rs 1946782 103.03 linear regression GE Creatinine Clearance at entry 2 9.52E-05 rs1946782 103.03 linear regression Creatinine Clearance at entry 2 1.07E-04 rs12463790 103.26 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 2.69E-04 rs1966908 103.35 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 4.56E-04 rs1966909 103.35 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 4.60E-04 rs10188434 119.52 linear regression Creatinine Clearance at entry 2 5.60E-05 rs10188434 119.52 linear regression GE Creatinine Clearance at entry 2 6.14E-05 rs7559347 119.52 linear regression Creatinine Clearance at entry 2 2.13E-04 rs7559347 119.52 linear regression GE Creatinine Clearance at entry 2 2.29E-04 rs13413437 119.53 linear regression Creatinine Clearance at entry 2 1.51 E-04 rs13413437 119.53 linear regression GE Creatinine Clearance at entry 2 1.65E-04 rs6760957 119.56 linear regression Creatinine Clearance at entry 2 2.14E-04 rs6760957 119.56 linear regression GE Creatinine Clearance at entry 2 2.30E-04 rs11897612 119.56 linear regression Creatinine Clearance at entry 2 4.25E-05 rs11897612 119.56 linear regression GE Creatinine Clearance at entry 2 4.66E-05 rs6431005 134.01 linear regression GE Albumin/Creatinine ratio at entry 2 2.05E-04 rs6431005 134.01 linear regression Albumin/Creatinine ratio at entry 2 3.21 E-04 rs6431005 134.01 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 4.11 E-04 rs17660836 147.05 linear regression AGE, SEX Creatinine Clearance at entry 2 4.55E-04 rs2704785 149.97 linear regression Albumin/Creatinine ratio at entry 2 8.04E-05 rs2704785 149.97 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 9.01 E-05

rs2704785 149.97 linear regression GE Albumin/Creatinine ratio at entry 2 1.28E-04 rs2704785 149.97 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 2 1.43E-04 rs1370521 149.97 linear regression Albumin/Creatinine ratio at entry 2 5.28E-05 rs1370521 149.97 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 5.84E-05 rs1370521 149.97 linear regression GE Albumin/Creatinine ratio at entry 2 8.54E-05 rs1370521 149.97 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 9.38E-05 rs10166160 170.17 linear regression GE Albumin/Creatinine ratio at entry 2 2.93E-04 rs10166160 170.17 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 2.97E-04 rs10166160 170.17 linear regression Albumin/Creatinine ratio at entry 2 3.85E-04 rs10166160 170.17 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 4.25E-04 rs4387746 170.17 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 4.69E-04 rs4387746 170.17 linear regression GE Albumin/Creatinine ratio at entry 2 4.80E-04 rs4384747 170.17 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 2 4.35E-04 rs4384747 170.17 linear regression GE Albumin/Creatinine ratio at entry 2 4.50E-04 rs4667546 171.36 linear regression AGE, SEX, GE Creatinine Clearance at entry 2 6.70E-05 rs4667546 171.36 linear regression AGE, SEX Creatinine Clearance at entry 2 9.59E-05 rs6728947 171.76 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 2 2.19E-04 rs6728947 171.76 linear regression Albumin/Creatinine ratio at entry 2 2.25E-04 rs6728947 171.76 linear regression GE Albumin/Creatinine ratio at entry 2 4.67E-04 rs6728947 171.76 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 2 4.76E-04 rs6433441 177.31 linear regression AGE, SEX Creatinine Clearance at entry 2 3.73E-04 rs1024125 177.31 linear regression AGE ₁ SEX Creatinine Clearance at entry 2 3.15E-04 rs1550293 195.91 linear regression Creatinine Clearance at entry 2 2.17E-04 rs1550293 195.91 linear regression GE Creatinine Clearance at entry 2 2.19E-04 rs17714747 199.24 linear regression GE Creatinine Clearance at entry 2 1.70E-04 rs17714747 199.24 linear regression Creatinine Clearance at entry 2 1.81 E-04 rs16838081 202.47 linear regression Albumin/Creatinine ratio at entry 2 3.18E-04 rs16838081 202.47 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 3.72E-04 rs16838081 202.47 linear regression GE Albumin/Creatinine ratio at entry 2 4.39E-04 rs1430220 220.90 linear regression AGE, SEX, GE Creatinine Clearance at entry 2 4.40E-04 rs10933355 235.05 linear regression Albumin/Creatinine ratio at entry 2 4.93E-04 rs809639 239.72 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 1.04E-04 rs809639 239.72 linear regression GE Albumin/Creatinine ratio at entry 2 1.67E-04 rs809639 239.72 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 4.03E-04 rs709934 239.73 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 2 5.10E-05 rs709934 239.73 linear regression GE Albumin/Creatinine ratio at entry 2 7.97E-05

rs709934 239.73 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 2.18E-04 rs709934 239.73 linear regression Albumin/Creatinine ratio at entry 2 2.84E-04 rs778340 239.74 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 6.82E-05 rs778340 239.74 linear regression GE Albumin/Creatinine ratio at entry 2 1.07E-04 rs778340 239.74 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 2.88E-04 rs778340 239.74 linear regression Albumin/Creatinine ratio at entry 2 3.73E-04 rs2675967 239.75 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 2 7.97E-05 rs2675967 239.75 linear regression GE Albumin/Creatinine ratio at entry 2 1.22E-04 rs2675967 239.75 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 3.17E-04 rs2675967 239.75 linear regression Albumin/Creatinine ratio at entry 2 4.07E-04 rs2592115 239.75 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 3.46E-05 rs2592115 239.75 linear regression GE Albumin/Creatinine ratio at entry 2 5.95E-05 rs2592115 239.75 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 1.41 E-04 rs2592115 239.75 linear regression Albumin/Creatinine ratio at entry 2 1.94E-04 rs6431234 244.21 linear regression Creatinine Clearance at entry 2 1.23E-04 rs6431234 244.21 linear regression GE Creatinine Clearance at entry 2 1.31 E-04 rs4663163 245.17 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 1.29E-05 rs4663163 245.17 linear regression Albumin/Creatinine ratio at entry 2 1.56E-05 o rs4663163 245.17 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 2 3.54E-05 rs4663163 245.17 linear regression GE Albumin/Creatinine ratio at entry 2 4.04E-05 rs4663165 245.17 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 3.12E-06 rs4663165 245.17 linear regression Albumin/Creatinine ratio at entry 2 3.96E-06 rs4663165 245.17 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 9.93E-06 rs4663165 245.17 linear regression GE Albumin/Creatinine ratio at entry 2 1.17E-05 rs4381737 248.23 linear regression GE Albumin/Creatinine ratio at entry 2 1.01 E-04 rs4381737 248.23 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 2 1.38E-04 rs4381737 248.23 linear regression Albumin/Creatinine ratio at entry 2 2.01 E-04 rs4381737 248.23 linear regression AGE, SEX Albumin/Creatinine ratio at entry 2 2.59E-04 rs304060 16.93 linear regression AGE, SEX Creatinine Clearance at entry 3 1.96E-04 rs304060 16.93 linear regression AGE, SEX, GE Creatinine Clearance at entry 3 4.01 E-04 rs17043569 19.83 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 4.30E-06 rs17043569 19.83 linear regression GE Albumin/Creatinine ratio at entry 3 4.71 E-06 rs17043569 19.83 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 5.56E-06 rs17043569 19.83 linear regression Albumin/Creatinine ratio at entry 3 6.41 E-06 rs17031374 19.83 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 3.01 E-06 rs17031374 19.83 linear regression GE Albumin/Creatinine ratio at entry 3 3.18E-06

rs17031374 19.83 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 4.34E-06 rs17031374 19.83 linear regression Albumin/Creatinine ratio at entry 3 4.76E-06 rs17233898 19.83 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 4.28E-05 rs17233898 19.83 linear regression GE Albumin/Creatinine ratio at entry 3 4.55E-05 rs17233898 19.83 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 7.27E-05 rs17233898 19.83 linear regression Albumin/Creatinine ratio at entry 3 7.83E-05 rs17043640 19.89 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 5.44E-05 rs17043640 19.89 linear regression GE Albumin/Creatinine ratio at entry 3 6.70E-05 rs17043640 19.89 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 1.40E-04 rs17043640 19.89 linear regression Albumin/Creatinine ratio at entry 3 1.58E-04 rs1836586 19.96 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 3.17E-04 rs1836586 19.96 linear regression GE Albumin/Creatinine ratio at entry 3 4.06E-04 rs9821016 25.61 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 3.72E-04 rs9821016 25.61 linear regression GE Albumin/Creatinine ratio at entry 3 3.79E-04 rs9821016 25.61 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 4.51 E-04 rs9821016 25.61 linear regression Albumin/Creatinine ratio at entry 3 4.51 E-04 rs617621 43.52 linear regression Albumin/Creatinine ratio at entry 3 2.20E-04 a, rs617621 43.52 linear regression GE Albumin/Creatinine ratio at entry 3 2.21 E-04

£ rs617621 43.52 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 3.33E-04 rs617621 43.52 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 3 3.46E-04 rs9866755 51.18 linear regression AGE, SEX Creatinine Clearance at entry 3 4.54E-04 rs10865809 51.26 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 2.72E-04 rs10865809 51.26 linear regression Albumin/Creatinine ratio at entry 3 3.14E-04 rs10865809 51.26 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 4.36E-04 rs10865809 51.26 linear regression GE Albumin/Creatinine ratio at entry 3 4.93E-04 rs9826565 51.26 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 3.85E-05 rs9826565 51.26 linear regression Albumin/Creatinine ratio at entry 3 5.14E-05 rs9826565 51.26 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 7.00E-05 rs9826565 51.26 linear regression GE Albumin/Creatinine ratio at entry 3 9.11 E-05 rs898828 52.57 linear regression Creatinine Clearance at entry 3 1.66E-04 rs898828 52.57 linear regression GE Creatinine Clearance at entry 3 1.87E-04 rs922284 52.58 linear regression Creatinine Clearance at entry 3 4.13E-04 rs922284 52.58 linear regression GE Creatinine Clearance at entry 3 4.63E-04 rs6549869 52.58 linear regression Creatinine Clearance at entry 3 6.48E-05 rs6549869 52.58 linear regression GE Creatinine Clearance at entry 3 7.22E-05 rs12715148 52.94 linear regression GE Creatinine Clearance at entry 3 4.92E-04

rs1870703 56 21 linear regression GE Creatinine Clearance at entry 3 4 81 E-04 rs1870703 56 21 linear regression Creatinine Clearance at entry 3 4 89E-04 rs6790424 56 21 linear regression GE Creatinine Clearance at entry 3 4 01 E-04 rs6790424 56 21 linear regression Creatinine Clearance at entry 3 4 14E-04 rs6790706 56 21 linear regression GE Creatinine Clearance at entry 3 3 06E-04 rs6790706 56 21 linear regression Creatinine Clearance at entry 3 3 13E-04 rs6790622 58 22 linear regression GE Albumin/Creatinine ratio at entry 3 3 15E-04 rs6790622 58 22 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 3 53E-04 rs4683098 69 18 linear regression GE Albumin/Creatinine ratio at entry 3 3 21 E-04 rs4683098 69 18 linear regression Albumin/Creatinine ratio at entry 3 3 60E-04 rs4683098 69 18 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 4 44E-04 rs4683098 69 18 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 4 77E-04 rs1526591 71 74 linear regression AGE, SEX, GE Creatinine Clearance at entry 3 1 97E-04 rs1526591 71 74 linear regression AGE ₁ SEX Creatinine Clearance at entry 3 4 17E-04 rs34490488 88 48 linear regression Creatinine Clearance at entry 3 3 20E-04 rs34490488 88 48 linear regression GE Creatinine Clearance at entry 3 3 31 E-04 rs7640488 97 20 linear regression Albumin/Creatinine ratio at entry 3 2 85E-04 rs7640488 97 20 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 2 99E-04 rs7640488 97 20 linear regression GE Albumin/Creatinine ratio at entry 3 3 92E-04 rs7640488 97 20 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 4 24E-04 rs9310154 97 21 linear regression Albumin/Creatinine ratio at entry 3 4 43E-04 rs9310154 97 21 linear regression GE Albumin/Creatinine ratio at entry 3 4 91 E-04 rs9310154 97 21 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 4 92E-04 rs5011048 108 31 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 2 26E-04 rs5011048 108 31 linear regression Albumin/Creatinine ratio at entry 3 2 51 E-04 rs5011048 108 31 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 2 89E-04 rs5011048 108 31 linear regression GE Albumin/Creatinine ratio at entry 3 3 08E-04 rs6788511 108 37 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 2 88E-04 rs6788511 108 37 linear regression Albumin/Creatinine ratio at entry 3 4 02E-04 rs1457659 108 40 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 4 27E-04 rs11712997 113 12 linear regression GE Albumin/Creatinine ratio at entry 3 3 98E-04 rs995082 113 69 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 5 42E-05 rs995082 113 69 linear regression Albumin/Creatinine ratio at entry 3 6 76E-05 rs995082 113 69 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 1 63E-04 rs995082 113 69 linear regression GE Albumin/Creatinine ratio at entry 3 1 84E-04 rs10511147 113 70 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 1 69E-04

rs10511147 113.70 linear regression Albumin/Creatinine ratio at entry 3 1.90E-04 rs16835075 113.91 linear regression GE Creatinine Clearance at entry 3 3.59E-04 rs16835075 113.91 linear regression Creatinine Clearance at entry 3 4.10E-04 rs6440541 115.26 linear regression AGE, SEX Creatinine Clearance at entry 3 1.28E-04 rs6440541 115.26 linear regression AGE, SEX, GE Creatinine Clearance at entry 3 4.74E-04 rs900060 115.27 linear regression AGE ₁ SEX Creatinine Clearance at entry 3 7.44E-05 rs900060 115.27 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 3 2.81 E-04 rs16844734 117.80 linear regression Albumin/Creatinine ratio at entry 3 1.62E-04 rs16844734 117.80 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 1.87E-04 rs16844734 117.80 linear regression GE Albumin/Creatinine ratio at entry 3 2.74E-04 rs16844734 117.80 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 3.45E-04 rs3856765 117.80 linear regression Albumin/Creatinine ratio at entry 3 1.59E-04 rs3856765 117.80 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 1.85E-04 rs3856765 117.80 linear regression GE Albumin/Creatinine ratio at entry 3 2.73E-04 rs3856765 117.80 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 3 3.51 E-04 rs2670132 117.97 linear regression GE Creatinine Clearance at entry 3 3.72E-04 rs2670132 117.97 linear regression Creatinine Clearance at entry 3 3.84E-04 rs2670132 117.97 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 3 4.14E-04 rs3849511 118.17 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 3 4.90E-04 rs9843093 118.98 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 2.82E-04 rs9843093 118.98 linear regression GE Albumin/Creatinine ratio at entry 3 3.95E-04 rs7646681 118.98 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 2.57E-04 rs7646681 118.98 linear regression GE Albumin/Creatinine ratio at entry 3 3.59E-04 rs4682326 126.91 linear regression AGE, SEX, GE Creatinine Clearance at entry 3 3.98E-04 rs4682326 126.91 linear regression AGE, SEX Creatinine Clearance at entry 3 4.71 E-04 rs760383 143.21 linear regression AGE ₁ SEX Creatinine Clearance at entry 3 3.17E-04 rs6802276 150.21 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 3 1.12E-04 rs6802276 150.21 linear regression GE Creatinine Clearance at entry 3 2.92E-04 rs6802276 150.21 linear regression Creatinine Clearance at entry 3 3.75E-04 rs6802276 150.21 linear regression AGE, SEX Creatinine Clearance at entry 3 4.53E-04 rs1447595 150.21 linear regression AGE, SEX, GE Creatinine Clearance at entry 3 3.30E-05 rs1447595 150.21 linear regression AGE, SEX Creatinine Clearance at entry 3 8.86E-05 rs1401547 150.22 linear regression AGE, SEX, GE Creatinine Clearance at entry 3 2.63E-05 rs1401547 150.22 linear regression AGE, SEX Creatinine Clearance at entry 3 1.05E-04 rs1401547 150.22 linear regression GE Creatinine Clearance at entry 3 2.44E-04 rs1401547 150.22 linear regression Creatinine Clearance at entry 3 3.28E-04

rs9866627 150.24 linear regression AGE, SEX, GE Creatinine Clearance at entry 3 2.40E-05 rs9866627 150.24 linear regression GE Creatinine Clearance at entry 3 7.69E-05 rs9866627 150.24 linear regression AGE, SEX Creatinine Clearance at entry 3 9.09E-05 rs9866627 150.24 linear regression Creatinine Clearance at entry 3 1.03E-04 rs9871437 150.24 linear regression AGE, SEX, GE Creatinine Clearance at entry 3 3.30E-05 rs9871437 150.24 linear regression GE Creatinine Clearance at entry 3 9.24E-05 rs9871437 150.24 linear regression Creatinine Clearance at entry 3 1.23E-04 rs9871437 150.24 linear regression AGE, SEX Creatinine Clearance at entry 3 1.26E-04 rs10935316 152.27 linear regression Albumin/Creatinine ratio at entry 3 4.81 E-04 rs1400685 153.38 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 3 3.13E-04 rs1400685 153.38 linear regression AGE ₁ SEX Creatinine Clearance at entry 3 4.31 E-04 rs6791890 153.38 linear regression AGE, SEX, GE Creatinine Clearance at entry 3 4.56E-04 rs11927163 171.05 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 4.31 E-04 rs9829295 173.07 linear regression AGE, SEX Creatinine Clearance at entry 3 3.51 E-04 rs6773962 173.60 linear regression GE Albumin/Creatinine ratio at entry 3 2.44E-04 rs6773962 173.60 linear regression Albumin/Creatinine ratio at entry 3 3.81 E-04 rs6773962 173.60 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 4.00E-04 rs13095931 173.60 linear regression GE Albumin/Creatinine ratio at entry 3 2.55E-04

4- rs13095931 173.60 linear regression Albumin/Creatinine ratio at entry 3 4.10E-04 rs13095931 173.60 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 4.23E-04 rs9856007 190.72 linear regression AGE, SEX Creatinine Clearance at entry 3 3.28E-05 rs9856007 190.72 linear regression AGE, SEX, GE Creatinine Clearance at entry 3 4.09E-05 rs9856007 190.72 linear regression Creatinine Clearance at entry 3 1.03E-04 rs9856007 190.72 linear regression GE Creatinine Clearance at entry 3 1.10E-04 rs16831291 190.86 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 3 2.21 E-04 rs16831291 190.86 linear regression AGE, SEX Creatinine Clearance at entry 3 2.52E-04 rs3849423 190.88 linear regression AGE, SEX, GE Creatinine Clearance at entry 3 1.09E-04 rs3849423 190.88 linear regression AGE ₁ SEX Creatinine Clearance at entry 3 1.13E-04 rs16831394 190.90 linear regression AGE, SEX, GE Creatinine Clearance at entry 3 2.31 E-05 rs16831394 190.90 linear regression AGE, SEX Creatinine Clearance at entry 3 2.33E-05 rs4677766 220.08 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 3 2.66E-05 rs4677766 220.08 linear regression GE Albumin/Creatinine ratio at entry 3 3.08E-05 rs4677766 220.08 linear regression Albumin/Creatinine ratio at entry 3 7.23E-05 rs4677766 220.08 linear regression AGE, SEX Albumin/Creatinine ratio at entry 3 7.41 E-05 rs17751499 16.22 linear regression GE Creatinine Clearance at entry 4 8.49E-05 rs17751499 16.22 linear regression Creatinine Clearance at entry 4 1.02E-04

rs2013321 25.86 linear regression AGE, SEX Creatinine Clearance at entry 4 4.46E-04 rs16892579 28.98 linear regression GE Albumin/Creatinine ratio at entry 4 4.29E-04 rs16892587 28.99 linear regression GE Albumin/Creatinine ratio at entry 4 1.15E-05 rs16892587 28.99 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 4 1.33E-05 rs16892587 28.99 linear regression Albumin/Creatinine ratio at entry 4 5.30E-05 rs16892587 28.99 linear regression AGE, SEX Albumin/Creatinine ratio at entry 4 6.36E-05 rs16892595 28.99 linear regression GE Albumin/Creatinine ratio at entry 4 8.29E-06 rs16892595 28.99 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 4 9.68E-06 rs16892595 28.99 linear regression Albumin/Creatinine ratio at entry 4 4.27E-05 rs16892595 28.99 linear regression AGE, SEX Albumin/Creatinine ratio at entry 4 5.40E-05 rs17496667 29.46 linear regression GE Albumin/Creatinine ratio at entry 4 4.30E-04 rs11725538 30.55 linear regression AGE, SEX Creatinine Clearance at entry 4 4.98E-05 rs11725538 30.55 linear regression GE Creatinine Clearance at entry 4 5.42E-05 rs11725538 30.55 linear regression Creatinine Clearance at entry 4 6.53E-05 rs11725538 30.55 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 7.71 E-05 rs16894847 30.57 linear regression AGE, SEX Creatinine Clearance at entry 4 6.44E-05 rs16894847 30.57 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 1.01 E-04 rs16894847 30.57 linear regression GE Creatinine Clearance at entry 4 1.86E-04 en rs16894847 30.57 linear regression Creatinine Clearance at entry 4 2.19E-04 rs6823069 30.58 linear regression GE Creatinine Clearance at entry 4 8.91 E-05 rs6823069 30.58 linear regression Creatinine Clearance at entry 4 1.04E-04 rs6823069 30.58 linear regression AGE, SEX Creatinine Clearance at entry 4 1.40E-04 rs6823069 30.58 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 4 1.81 E-04 rs4698574 30.59 linear regression GE Creatinine Clearance at entry 4 9.37E-05 rs4698574 30.59 linear regression Creatinine Clearance at entry 4 1.04E-04 rs4698574 30.59 linear regression AGE, SEX Creatinine Clearance at entry 4 1.72E-04 rs4698574 30.59 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 2.00E-04 rs6449287 30.63 linear regression AGE, SEX Creatinine Clearance at entry 4 2.65E-04 rs6449287 30.63 linear regression GE Creatinine Clearance at entry 4 3.14E-04 rs6449287 30.63 linear regression Creatinine Clearance at entry 4 3.65E-04 rs6449287 30.63 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 4 4.11 E-04 rs13149932 32.35 linear regression AGE, SEX Albumin/Creatinine ratio at entry 4 1.34E-04 rs13149932 32.35 linear regression Albumin/Creatinine ratio at entry 4 1.91 E-04 rs6840808 39.36 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 4 2.12E-04 rs6840808 39.36 linear regression AGE, SEX Creatinine Clearance at entry 4 3.56E-04 rs1510699 43.37 linear regression AGE, SEX Albumin/Creatinine ratio at entry 4 3.00E-04

rs1961016 43.39 linear regression AGE, SEX Albumin/Creatinine ratio at entry 4 4.80E-04 rs1493135 43.54 linear regression GE Albumin/Creatinine ratio at entry 4 1.69E-04 rs1493135 43.54 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 4 1.75E-04 rs1493135 43.54 linear regression Albumin/Creatinine ratio at entry 4 3.50E-04 rs1493135 43.54 linear regression AGE, SEX Albumin/Creatinine ratio at entry 4 3.68E-04 rs41415444 43.55 linear regression GE Albumin/Creatinine ratio at entry 4 4.78E-04 rs41415444 43.55 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 4 4.86E-04 rs11727037 51.74 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 2.99E-04 rs11727037 51.74 linear regression AGE, SEX Creatinine Clearance at entry 4 3.46E-04 rs11729556 55.72 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 4 3.21 E-04 rs11729556 55.72 linear regression GE Albumin/Creatinine ratio at entry 4 3.46E-04 rs4695256 60.38 linear regression AGE ₁ SEX Creatinine Clearance at entry 4 9.15E-05 rs4695256 60.38 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 4 1.00E-04 rs13148787 102.07 linear regression AGE, SEX Creatinine Clearance at entry 4 4.35E-04 rs1506804 106.80 linear regression AGE, SEX Creatinine Clearance at entry 4 7.84E-05 rs1506804 106.80 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 4 8.33E-05 rs2659508 106.82 linear regression AGE, SEX Creatinine Clearance at entry 4 1.67E-05 rs2659508 106.82 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 1.68E-05 rs2659511 106.82 linear regression AGE, SEX Creatinine Clearance at entry 4 5.55E-05 rs2659511 106.82 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 4 5.57E-05 rs2659534 106.83 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 4 4.10E-05 rs2659534 106.83 linear regression AGE ₁ SEX Creatinine Clearance at entry 4 4.14E-05 rs6533014 107.30 linear regression AGE, SEX Albumin/Creatinine ratio at entry 4 1.66E-04 rs6533014 107.30 linear regression Albumin/Creatinine ratio at entry 4 2.22E-04 rs6533014 107.30 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 4 3.62E-04 rs6533014 107.30 linear regression GE Albumin/Creatinine ratio at entry 4 4.72E-04 rs17036102 109.41 linear regression GE Creatinine Clearance at entry 4 3.20E-04 rs17036102 109.41 linear regression Creatinine Clearance at entry 4 3.78E-04 rs17036142 109.45 linear regression GE Creatinine Clearance at entry 4 3.00E-04 rs17036142 109.45 linear regression Creatinine Clearance at entry 4 3.36E-04 rs17036142 109.45 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 3.52E-04 rs17036142 109.45 linear regression AGE ₁ SEX Creatinine Clearance at entry 4 3.71 E-04 rs17036156 109.50 linear regression GE Creatinine Clearance at entry 4 3.88E-04 rs17036156 109.50 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 3.90E-04 rs17036156 109.50 linear regression AGE, SEX Creatinine Clearance at entry 4 4.23E-04 rs17036156 109.50 linear regression Creatinine Clearance at entry 4 4.26E-04

rs11732298 109.56 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 4.55E-04 rs11732298 109.56 linear regression AGE, SEX Creatinine Clearance at entry 4 4.94E-04 rs17036230 109.58 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 4.55E-04 rs17036230 109.58 linear regression AGE, SEX Creatinine Clearance at entry 4 4.94E-04 rs343170 124.04 linear regression AGE, SEX Creatinine Clearance at entry 4 3.40E-04 rs343170 124.04 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 4.73E-04 rs13110738 124.41 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 4.20E-04 rs13110738 124.41 linear regression AGE, SEX Creatinine Clearance at entry 4 4.42E-04 rs13110738 124.41 linear regression GE Creatinine Clearance at entry 4 4.54E-04 rs13110738 124.41 linear regression Creatinine Clearance at entry 4 4.80E-04 rs13111562 155.87 linear regression Creatinine Clearance at entry 4 3.52E-04 rs13111562 155.87 linear regression GE Creatinine Clearance at entry 4 3.74E-04 rs17032901 155.92 linear regression Creatinine Clearance at entry 4 2.44E-04 rs17032901 155.92 linear regression GE Creatinine Clearance at entry 4 2.54E-04 rs10517818 165.21 linear regression AGE, SEX Creatinine Clearance at entry 4 3.80E-04 rs10517818 165.21 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 4.33E-04 rs17056139 171.36 linear regression Creatinine Clearance at entry 4 2.74E-04 rs17056139 171.36 linear regression GE Creatinine Clearance at entry 4 2.94E-04 rs17056322 171.97 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 4 3.14E-04 rs17056322 171.97 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 4 3.18E-04 rs17056322 171.97 linear regression Albumin/Creatinine ratio at entry 4 4.63E-04 rs1368003 171.98 linear regression AGE, SEX Albumin/Creatinine ratio at entry 4 1.68E-04 rs1368003 171.98 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 4 1.75E-04 rs1368003 171.98 linear regression Albumin/Creatinine ratio at entry 4 2.58E-04 rs1368003 171.98 linear regression GE Albumin/Creatinine ratio at entry 4 3.15E-04 rs17056330 171.98 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 4 3.26E-04 rs17056330 171.98 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 4 3.31 E-04 rs17056330 171.98 linear regression Albumin/Creatinine ratio at entry 4 4.82E-04 rs11934228 174.80 linear regression GE Albumin/Creatinine ratio at entry 4 4.17E-04 rs4404521 176.39 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 1.08E-04 rs4404521 176.39 linear regression AGE, SEX Creatinine Clearance at entry 4 1.27E-04 rs4404521 176.39 linear regression GE Creatinine Clearance at entry 4 2.39E-04 rs4404521 176.39 linear regression Creatinine Clearance at entry 4 2.47E-04 rs4476578 176.39 linear regression AGE, SEX, GE Creatinine Clearance at entry 4 1.32E-04 rs4476578 176.39 linear regression AGE, SEX Creatinine Clearance at entry 4 1.64E-04 rs4476578 176.39 linear regression GE Creatinine Clearance at entry 4 2.36E-04

rs4476578 176.39 linear regression Creatinine Clearance at entry 4 2.52E-04 rs1882331 194.18 linear regression Creatinine Clearance at entry 4 1.74E-05 rs1882331 194.18 linear regression GE Creatinine Clearance at entry 4 1.74E-05 rs2310000 194.21 linear regression Creatinine Clearance at entry 4 5.81 E-05 rs2310000 194.21 linear regression GE Creatinine Clearance at entry 4 5.88E-05 rs6887047 9.91 linear regression GE Creatinine Clearance at entry 5 1.67E-04 rs6887047 9.91 linear regression Creatinine Clearance at entry 5 1.69E-04 rs1002548 18.25 linear regression AGE, SEX Creatinine Clearance at entry 5 4.39E-04 rs1157651 18.29 linear regression AGE ₁ SEX Creatinine Clearance at entry 5 3.18E-04 rs1157651 18.29 linear regression AGE, SEX, GE Creatinine Clearance at entry 5 3.76E-04 rs26217 26.18 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 5 3.19E-04 rs257778 28.19 linear regression GE Albumin/Creatinine ratio at entry 5 2.68E-04 rs257778 28.19 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 2.76E-04 rs257737 28.23 linear regression GE Albumin/Creatinine ratio at entry 5 3.10E-04 rs257737 28.23 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 3.46E-04 rs257741 28.24 linear regression GE Albumin/Creatinine ratio at entry 5 2.16E-04 rs257741 28.24 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 5 2.47E-04 rs12188594 28.28 linear regression GE Albumin/Creatinine ratio at entry 5 3.19E-04 rs12188594 28.28 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 3.53E-04 rs12655096 59.38 linear regression AGE, SEX, GE Creatinine Clearance at entry 5 2.40E-05 rs12655096 59.38 linear regression AGE, SEX Creatinine Clearance at entry 5 2.47E-05 rs2021394 68.12 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 5 4.76E-04 rs1437121 103.87 linear regression Albumin/Creatinine ratio at entry 5 1.00E-04 rs1437121 103.87 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 1.08E-04 rs1437121 103.87 linear regression GE Albumin/Creatinine ratio at entry 5 4.90E-04 rs7715499 103.88 linear regression Albumin/Creatinine ratio at entry 5 1.93E-04 rs7715499 103.88 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 2.07E-04 rs17334370 109.06 linear regression Albumin/Creatinine ratio at entry 5 6.71 E-06 rs17334370 109.06 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 5 8.12E-06 rs17334370 109.06 linear regression GE Albumin/Creatinine ratio at entry 5 2.10E-05 rs17334370 109.06 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 3.35E-05 rs1378500 117.11 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 4.85E-05 rs1378500 117.11 linear regression Albumin/Creatinine ratio at entry 5 5.00E-05 rs1378500 117.11 linear regression GE Albumin/Creatinine ratio at entry 5 7.13E-05 rs1378500 117.11 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 7.73E-05 rs2954365 121.29 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 2.06E-04

rs2954365 121.29 linear regression Albumin/Creatinine ratio at entry 5 2.86E-04 rs11959439 129.61 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 2.77E-04 rs11959439 129.61 linear regression Albumin/Creatinine ratio at entry 5 3.31 E-04 rs11959439 129.61 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 4.75E-04 rs1816847 129.62 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 4.97E-05 rs1816847 129.62 linear regression Albumin/Creatinine ratio at entry 5 5.01 E-05 rs1816847 129.62 linear regression GE Albumin/Creatinine ratio at entry 5 8.33E-05 rs1816847 129.62 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 1.00E-04 rs718734 129.62 linear regression Albumin/Creatinine ratio at entry 5 6.21 E-05 rs718734 129.62 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 6.21 E-05 rs718734 129.62 linear regression GE Albumin/Creatinine ratio at entry 5 1.02E-04 rs718734 129.62 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 1.24E-04 rs10045387 129.62 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 2.78E-05 rs10045387 129.62 linear regression Albumin/Creatinine ratio at entry 5 2.79E-05 rs10045387 129.62 linear regression GE Albumin/Creatinine ratio at entry 5 3.83E-05 rs10045387 129.62 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 5 4.47E-05 rs347559 129.62 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 2.22E-05 rs347559 129.62 linear regression Albumin/Creatinine ratio at entry 5 2.24E-05

VO rs347559 129.62 linear regression GE Albumin/Creatinine ratio at entry 5 3.15E-05 rs347559 129.62 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 3.67E-05 rs347558 129.62 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 2.08E-05 rs347558 129.62 linear regression Albumin/Creatinine ratio at entry 5 2.11 E-05 rs347558 129.62 linear regression GE Albumin/Creatinine ratio at entry 5 2.86E-05 rs347558 129.62 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 3.29E-05 rs17146098 129.62 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 3.42E-05 rs17146098 129.62 linear regression Albumin/Creatinine ratio at entry 5 3.45E-05 rs17146098 129.62 linear regression GE Albumin/Creatinine ratio at entry 5 4.86E-05 rs17146098 129.62 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 5.67E-05 rs6595209 129.63 linear regression Albumin/Creatinine ratio at entry 5 5.76E-05 rs6595209 129.63 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 6.07E-05 rs6595209 129.63 linear regression GE Albumin/Creatinine ratio at entry 5 8.95E-05 rs6595209 129.63 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 1.13E-04 rs982605 129.63 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 8.09E-05 rs982605 129.63 linear regression Albumin/Creatinine ratio at entry 5 8.19E-05 rs982605 129.63 linear regression' GE Albumin/Creatinine ratio at entry 5 1.30E-04 rs982605 129.63 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 1.55E-04

rs17146179 129.63 linear regression Albumin/Creatinine ratio at entry 5 5.20E-05 rs17146179 129.63 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 5.28E-05 rs17146179 129.63 linear regression GE Albumin/Creatinine ratio at entry 5 8.29E-05 rs17146179 129.63 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 1.02E-04 rs982358 129.63 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 5 7.21 E-05 rs982358 129.63 linear regression Albumin/Creatinine ratio at entry 5 7.51 E-05 rs982358 129.63 linear regression GE Albumin/Creatinine ratio at entry 5 1.19E-04 rs982358 129.63 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 1.38E-04 rs6872465 130.36 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 2.78E-04 rs6872465 130.36 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 4.26E-04 rs6872465 130.36 linear regression Albumin/Creatinine ratio at entry 5 4.76E-04 rs6595849 133.52 linear regression Creatinine Clearance at entry 5 5.71 E-05 rs6595849 133.52 linear regression GE Creatinine Clearance at entry 5 6.09E-05 rs4705945 135.50 linear regression Albumin/Creatinine ratio at entry 5 3.40E-04 rs4705945 135.50 linear regression GE Albumin/Creatinine ratio at entry 5 4.23E-04 rs4705945 135.50 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 4.99E-04 rs930056 136.72 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 5 8.13E-06

^ rs930056 136.72 linear regression GE Albumin/Creatinine ratio at entry 5 8.57E-06 o rs930056 136.72 linear regression Albumin/Creatinine ratio at entry 5 4.87E-05 rs930056 136.72 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 5.45E-05 rs9686988 136.73 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 3.94E-05 rs9686988 136.73 linear regression GE Albumin/Creatinine ratio at entry 5 4.36E-05 rs9686988 136.73 linear regression Albumin/Creatinine ratio at entry 5 1.64E-04 rs9686988 136.73 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 1.77E-04 rs2864246 136.74 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 5 1.53E-04 rs2864246 136.74 linear regression GE Albumin/Creatinine ratio at entry 5 1.86E-04 rs2239544 137.72 linear regression AGE, SEX, GE Creatinine Clearance at entry 5 1.86E-04 rs2239544 137.72 linear regression AGE, SEX Creatinine Clearance at entry 5 3.33E-04 rs328043 137.88 linear regression AGE, SEX, GE Creatinine Clearance at entry 5 8.04E-05 rs328043 137.88 linear regression AGE, SEX Creatinine Clearance at entry 5 1.51 E-04 rs740662 144.36 linear regression GE Albumin/Creatinine ratio at entry 5 4.25E-04 rs7717186 148.21 linear regression Albumin/Creatinine ratio at entry 5 4.75E-04 rs1504935 158.82 linear regression AGE, SEX Creatinine Clearance at entry 5 2.23E-04 rs1504935 158.82 linear regression AGE, SEX, GE Creatinine Clearance at entry 5 2.58E-04 rs10515781 162.02 linear regression AGE, SEX Creatinine Clearance at entry 5 2.54E-04 rs10515781 162.02 linear regression AGE ₁ SEX, GE Creatinine Clearance at entry 5 2.87E-04

rs6887080 162.03 linear regression AGE, SEX Creatinine Clearance at entry 5 2.28E-04 rs6887080 162.03 linear regression AGE, SEX, GE Creatinine Clearance at entry 5 2.52E-04 rs4921209 162.03 linear regression AGE, SEX Creatinine Clearance at entry 5 2.68E-04 rs4921209 162.03 linear regression AGE, SEX, GE Creatinine Clearance at entry 5 2.84E-04 rs4334868 162.17 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 3.64E-04 rs4334868 162.17 linear regression Albumin/Creatinine ratio at entry 5 4.73E-04 rs6883415 164.11 linear regression Albumin/Creatinine ratio at entry 5 4.40E-04 rs6883415 164.11 linear regression AGE, SEX Albumin/Creatinine ratio at entry 5 4.81 E-04 rs3797716 173.75 linear regression AGE, SEX, GE Creatinine Clearance at entry 5 1.86E-04 rs3797716 173.75 linear regression AGE, SEX Creatinine Clearance at entry 5 2.36E-04 rs9885206 173.76 linear regression AGE, SEX, GE Creatinine Clearance at entry 5 1.80E-04 rs9885206 173.76 linear regression AGE, SEX Creatinine Clearance at entry 5 2.02E-04 rs905800 173.77 linear regression AGE, SEX, GE Creatinine Clearance at entry 5 2.93E-04 rs905800 173.77 linear regression AGE, SEX Creatinine Clearance at entry 5 2.96E-04 rs2731699 179.34 linear regression GE Creatinine Clearance at entry 5 1.87E-04 rs2731699 179.34 linear regression Creatinine Clearance at entry 5 1.96E-04 rs11134856 184.90 linear regression AGE ₁ SEX Creatinine Clearance at entry 5 2.91 E-04 rs11134856 184.90 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 5 3.14E-04 rs6596974 5.23 linear regression Creatinine Clearance at entry 6 3.54E-04 rs6596974 5.23 linear regression GE Creatinine Clearance at entry 6 3.55E-04 rs6596976 5.23 linear regression Creatinine Clearance at entry 6 3.54E-04 rs6596976 5.23 linear regression GE Creatinine Clearance at entry 6 3.55E-04 rs7747217 5.45 linear regression Creatinine Clearance at entry 6 4.87E-04 rs11963940 14.25 linear regression GE Creatinine Clearance at entry 6 4.19E-04 rs11963940 14.25 linear regression Creatinine Clearance at entry 6 4.31 E-04 rs4959483 14.26 linear regression GE Creatinine Clearance at entry 6 2.77E-04 rs4959483 14.26 linear regression Creatinine Clearance at entry 6 2.83E-04 rs6936890 19.96 linear regression GE Albumin/Creatinine ratio at entry 6 4.70E-05 rs6936890 19.96 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 6 5.49E-05 rs6936890 19.96 linear regression Albumin/Creatinine ratio at entry 6 9.23E-05 rs6936890 19.96 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 6 1.10E-04 rs474519 19.99 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 6 4.32E-05 rs474519 19.99 linear regression GE Albumin/Creatinine ratio at entry 6 4.46E-05 rs474519 19.99 linear regression Albumin/Creatinine ratio at entry 6 8.60E-05 rs474519 19.99 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 8.83E-05 rs3857545 20.06 linear regression Albumin/Creatinine ratio at entry 6 1.11 E-05

rs3857545 20.06 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 6 1.16E-05 rs3857545 20.06 linear regression GE Albumin/Creatinine ratio at entry 6 1.29E-05 rs3857545 20.06 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 6 1.30E-05 rs9393680 20.06 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 4.73E-05 rs9393680 20.06 linear regression Albumin/Creatinine ratio at entry 6 6.22E-05 rs9393680 20.06 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 6 8.43E-05 rs9393680 20.06 linear regression GE Albumin/Creatinine ratio at entry 6 1.11 E-04 rs6932716 29.59 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 1.68E-04 rs6932716 29.59 linear regression Albumin/Creatinine ratio at entry 6 2.55E-04 rs6932716 29.59 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 6 4.71 E-04 rs6931813 29.59 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 1.82E-04 rs6931813 29.59 linear regression Albumin/Creatinine ratio at entry 6 2.69E-04 rs6931813 29.59 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 6 4.99E-04 rs16877335 29.59 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 1.36E-04 rs16877335 29.59 linear regression Albumin/Creatinine ratio at entry 6 2.00E-04 rs16877335 29.59 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 6 3.67E-04 rs7739957 29.61 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 1.25E-04 rs7739957 29.61 linear regression Albumin/Creatinine ratio at entry 6 1.85E-04

4- rs7739957 29.61 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 6 3.71 E-04 rs9283873 39.22 linear regression Creatinine Clearance at entry 6 2.04E-04 rs9283873 39.22 linear regression GE Creatinine Clearance at entry 6 2.06E-04 rs9368402 39.23 linear regression GE Creatinine Clearance at entry 6 1.85E-04 rs9368402 39.23 linear regression Creatinine Clearance at entry 6 2.01 E-04 rs9275134 45.67 linear regression GE Albumin/Creatinine ratio at entry 6 3.68E-04 rs9275134 45.67 linear regression Albumin/Creatinine ratio at entry 6 4.29E-04 rs9275134 45.67 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 6 4.65E-04 rs2856688 45.67 linear regression GE Albumin/Creatinine ratio at entry 6 1.67E-04 rs2856688 45.67 linear regression Albumin/Creatinine ratio at entry 6 1.90E-04 rs2856688 45.67 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 6 1.97E-04 rs2856688 45.67 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 6 2.16E-04 rs4713784 46.98 linear regression Creatinine Clearance at entry 6 2.13E-05 rs4713784 46.98 linear regression GE Creatinine Clearance at entry 6 2.28E-05 rs4713784 46.98 linear regression AGE, SEX, GE Creatinine Clearance at entry 6 5.24E-05 rs4713784 46.98 linear regression AGE, SEX Creatinine Clearance at entry 6 7.99E-05 rs2766551 48.51 linear regression AGE, SEX Creatinine Clearance at entry 6 1.69E-04 rs2766551 48.51 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 6 3.90E-04

rs534685 77.02 linear regression AGE ₁ SEX Creatinine Clearance at entry 6 1.47E-04 rs534685 77.02 linear regression AGE, SEX, GE Creatinine Clearance at entry 6 1.48E-04 rs541689 77.02 linear regression AGE, SEX, GE Creatinine Clearance at entry 6 8.79E-05 rs541689 77.02 linear regression AGE, SEX Creatinine Clearance at entry 6 8.84E-05 rs608873 77.02 linear regression AGE, SEX Creatinine Clearance at entry 6 2.75E-04 rs608873 77.02 linear regression AGE, SEX, GE Creatinine Clearance at entry 6 2.80E-04 rs16885649 77.03 linear regression AGE, SEX Creatinine Clearance at entry 6 2.92E-04 rs16885649 77.03 linear regression AGE, SEX, GE Creatinine Clearance at entry 6 3.05E-04 rs16885654 77.03 linear regression AGE, SEX Creatinine Clearance at entry 6 1.49E-04 rs16885654 77.03 linear regression AGE, SEX, GE Creatinine Clearance at entry 6 1.55E-04 rs7740110 77.04 linear regression AGE, SEX Creatinine Clearance at entry 6 1.76E-04 rs7740110 77.04 linear regression AGE, SEX, GE Creatinine Clearance at entry 6 1.87E-04 rs11754490 81.49 linear regression AGE, SEX Creatinine Clearance at entry 6 4.54E-04 rs16896055 81.49 linear regression AGE, SEX Creatinine Clearance at entry 6 4.52E-04 rs7747972 82.21 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 4.08E-04 rs7761326 82.21 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 6 4.14E-04 rs696990 83.67 linear regression AGE, SEX Creatinine Clearance at entry 6 2.58E-04 rs696990 83.67 linear regression AGE, SEX, GE Creatinine Clearance at entry 6 4.02E-04 rs667857 83.67 linear regression AGE ₁ SEX Creatinine Clearance at entry 6 2.18E-04 rs667857 83.67 linear regression AGE, SEX, GE Creatinine Clearance at entry 6 3.40E-04 rs7752409 83.73 linear regression AGE, SEX, GE Creatinine Clearance at entry 6 2.06E-04 rs7752409 83.73 linear regression AGE, SEX Creatinine Clearance at entry 6 3.76E-04 rs7769582 83.75 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 6 2.31 E-04 rs7769582 83.75 linear regression AGE, SEX Creatinine Clearance at entry 6 4.23E-04 rs16869370 83.77 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 6 2.18E-04 rs16869370 83.77 linear regression AGE, SEX Creatinine Clearance at entry 6 3.59E-04 rs9455160 83.77 linear regression AGE, SEX, GE Creatinine Clearance at entry 6 2.03E-04 rs9455160 83.77 linear regression AGE, SEX Creatinine Clearance at entry 6 3.68E-04 rs10945231 83.78 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 6 4.86E-04 rs9351813 84.13 linear regression GE Albumin/Creatinine ratio at entry 6 1.39E-05 rs9351813 84.13 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 6 1.51 E-05 rs9351813 84.13 linear regression Albumin/Creatinine ratio at entry 6 2.10E-05 rs9351813 84.13 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 2.37E-05 rs852928 84.14 linear regression GE Albumin/Creatinine ratio at entry 6 3.82E-04 rs852928 84.14 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 6 3.95E-04 rs9351816 84.14 linear regression GE Albumin/Creatinine ratio at entry 6 9.43E-07

rs9351816 84.14 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 6 1.25E-06 rs9351816 84.14 linear regression Albumin/Creatinine ratio at entry 6 2.06E-06 rs9351816 84.14 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 2.84E-06 rs236855 89.11 linear regression AGE, SEX, GE Creatinine Clearance at entry 6 4.52E-04 rs6911435 90.38 linear regression AGE, SEX Creatinine Clearance at entry 6 4.02E-04 rs559663 100.28 linear regression Creatinine Clearance at entry 6 4.18E-05 rs559663 100.28 linear regression GE Creatinine Clearance at entry 6 4.50E-05 rs539526 100.32 linear regression Creatinine Clearance at entry 6 2.21 E-05 rs539526 100.32 linear regression GE Creatinine Clearance at entry 6 2.27E-05 rs1206157 103.63 linear regression Creatinine Clearance at entry 6 2.03E-04 rs1206157 103.63 linear regression GE Creatinine Clearance at entry 6 2.19E-04 rs6906007 137.74 linear regression GE Albumin/Creatinine ratio at entry 6 2.08E-04 rs6906007 137.74 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 6 2.34E-04 rs10872466 137.74 linear regression GE Albumin/Creatinine ratio at entry 6 3.74E-04 rs10872466 137.74 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 6 4.24E-04 rs1891487 137.74 linear regression GE Albumin/Creatinine ratio at entry 6 4.52E-04 rs4870149 153.87 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 4.09E-04 rs4870150 153.87 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 4.37E-04 rs2465836 165.54 linear regression Creatinine Clearance at entry 6 8.82E-05 rs2465836 165.54 linear regression GE Creatinine Clearance at entry 6 9.48E-05 rs1620969 165.55 linear regression Creatinine Clearance at entry 6 5.25E-05 rs1620969 165.55 linear regression GE Creatinine Clearance at entry 6 5.76E-05 rs4710013 178.75 linear regression Albumin/Creatinine ratio at entry 6 2.04E-04 rs4710013 178.75 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 2.54E-04 rs3099280 178.84 linear regression GE Albumin/Creatinine ratio at entry 6 1.79E-04 rs3099280 178.84 linear regression Albumin/Creatinine ratio at entry 6 2.60E-04 rs3099280 178.84 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 6 2.65E-04 rs3099280 178.84 linear regression AGE, SEX Albumin/Creatinine ratio at entry 6 3.59E-04 rs1002170 3.04 linear regression Albumin/Creatinine ratio at entry 7 2.65E-04 rs1002170 3.04 linear regression AGE, SEX Albumin/Creatinine ratio at entry 7 2.78E-04 rs1002169 3.04 linear regression Albumin/Creatinine ratio at entry 7 2.33E-04 rs1002169 3.04 linear regression AGE, SEX Albumin/Creatinine ratio at entry 7 2.45E-04 rs37965 13.77 linear regression AGE, SEX, GE Creatinine Clearance at entry 7 1.47E-04 rs37965 13.77 linear regression AGE, SEX Creatinine Clearance at entry 7 1.60E-04 rs10234484 15.66 linear regression GE Creatinine Clearance at entry 7 1.16E-04 rs10234484 15.66 linear regression Creatinine Clearance at entry 7 1.28E-04

rs887939 15.67 linear regression GE Creatinine Clearance at entry 7 2.14E-04 rs887939 15.67 linear regression Creatinine Clearance at entry 7 2.34E-04 rs245659 15.68 linear regression GE Creatinine Clearance at entry 7 4.28E-04 rs245659 15.68 linear regression Creatinine Clearance at entry 7 4.68E-04 rs17167930 21.61 linear regression Creatinine Clearance at entry 7 3.68E-04 rs17167930 21.61 linear regression GE Creatinine Clearance at entry 7 3.91 E-04 rs39413 38.95 linear regression Creatinine Clearance at entry 7 4.94E-04 rs39413 38.95 linear regression GE Creatinine Clearance at entry 7 4.96E-04 rs6966228 72.08 linear regression AGE ₁ SEX Creatinine Clearance at entry 7 4.21 E-04 rs6966228 72.08 linear regression GE Creatinine Clearance at entry 7 4.40E-04 rs6966228 72.08 linear regression Creatinine Clearance at entry 7 4.65E-04 rs6966228 72.08 linear regression AGE, SEX, GE Creatinine Clearance at entry 7 4.92E-04 rs4947833 74.44 linear regression Creatinine Clearance at entry 7 2.56E-04 rs4947833 74.44 linear regression GE Creatinine Clearance at entry 7 2.73E-04 rs1534735 74.44 linear regression GE Creatinine Clearance at entry 7 4.69E-04 rs1534735 74.44 linear regression Creatinine Clearance at entry 7 4.74E-04 rs3108049 78.48 linear regression Albumin/Creatinine ratio at entry 7 4.24E-04 rs3108049 78.48 linear regression AGE, SEX Albumin/Creatinine ratio at entry 7 4.25E-04

4- rs7811306 97.27 linear regression AGE, SEX, GE Creatinine Clearance at entry 7 3.62E-04 rs2726002 97.33 linear regression AGE, SEX, GE Creatinine Clearance at entry 7 2.87E-04 rs2726002 97.33 linear regression AGE, SEX Creatinine Clearance at entry 7 3.73E-04 rs4560725 97.33 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 7 2.64E-04 rs4560725 97.33 linear regression AGE, SEX Creatinine Clearance at entry 7 3.46E-04 rs10808062 97.34 linear regression AGE, SEX, GE Creatinine Clearance at entry 7 2.87E-04 rs10808062 97.34 linear regression AGE, SEX Creatinine Clearance at entry 7 3.73E-04 rs6949471 97.34 linear regression AGE, SEX, GE Creatinine Clearance at entry 7 3.20E-04 rs6949471 97.34 linear regression AGE ₁ SEX Creatinine Clearance at entry 7 4.31 E-04 rs12704196 97.34 linear regression AGE, SEX, GE Creatinine Clearance at entry 7 2.57E-04 rs12704196 97.34 linear regression AGE, SEX Creatinine Clearance at entry 7 3.30E-04 rs12704200 97.35 linear regression AGE, SEX, GE Creatinine Clearance at entry 7 1.64E-04 rs12704200 97.35 linear regression AGE, SEX Creatinine Clearance at entry 7 2.28E-04 rs10238931 97.38 linear regression AGE, SEX, GE Creatinine Clearance at entry 7 4.08E-04 rs2214847 110.16 linear regression GE Creatinine Clearance at entry 7 4.54E-04 rs2214847 110.16 linear regression Creatinine Clearance at entry 7 4.84E-04 rs41633 110.21 linear regression GE Creatinine Clearance at entry 7 2.07E-04 rs41633 110.21 linear regression Creatinine Clearance at entry 7 2.23E-04

rs2283015 110.24 linear regression GE Creatinine Clearance at entry 7 2.04E-04 rs2283015 110.24 linear regression Creatinine Clearance at entry 7 2.21 E-04 rs4729505 110.24 linear regression GE Creatinine Clearance at entry 7 2.11 E-04 rs4729505 110.24 linear regression Creatinine Clearance at entry 7 2.29E-04 rs2237601 110.24 linear regression GE Creatinine Clearance at entry 7 3.38E-04 rs2237601 110.24 linear regression Creatinine Clearance at entry 7 3.61 E-04 rs1007007 110.25 linear regression GE Creatinine Clearance at entry 7 1.21 E-04 rs1007007 110.25 linear regression Creatinine Clearance at entry 7 1.31 E-04 rs7787976 113.60 linear regression AGE, SEX Creatinine Clearance at entry 7 2.33E-04 rs7787976 113.60 linear regression AGE, SEX, GE Creatinine Clearance at entry 7 4.98E-04 rs2106303 117.14 linear regression Creatinine Clearance at entry 7 4.61 E-04 rs2106303 117.14 linear regression GE Creatinine Clearance at entry 7 4.73E-04 rs10248657 122.45 linear regression GE Creatinine Clearance at entry 7 4.89E-04 rs7795646 125.03 linear regression AGE, SEX Albumin/Creatinine ratio at entry 7 8.88E-05 rs7795646 125.03 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 7 1.07E-04 rs7795646 125.03 linear regression Albumin/Creatinine ratio at entry 7 1.20E-04 rs7795646 125.03 linear regression GE Albumin/Creatinine ratio at entry 7 1.44E-04 rs12670939 127.72 linear regression AGE, SEX Albumin/Creatinine ratio at entry 7 1.87E-04

4- rs12670939 127.72 linear regression Albumin/Creatinine ratio at entry 7 1.94E-04 rs12670939 127.72 linear regression GE Albumin/Creatinine ratio at entry 7 2.19E-04 rs12670939 127.72 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 7 2.21 E-04 rs7789785 133.65 linear regression AGE, SEX Creatinine Clearance at entry 7 1.42E-04 rs7789785 133.65 linear regression AGE, SEX, GE Creatinine Clearance at entry 7 1.95E-04 rs1455857 142.51 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 7 4.29E-04 rs1455857 142.51 linear regression Albumin/Creatinine ratio at entry 7 4.82E-04 rs7807871 142.54 linear regression AGE, SEX Albumin/Creatinine ratio at entry 7 1.62E-04 rs7807871 142.54 linear regression Albumin/Creatinine ratio at entry 7 1.89E-04 rs7807871 142.54 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 7 3.02E-04 rs7807871 142.54 linear regression GE Albumin/Creatinine ratio at entry 7 3.24E-04 rs2350786 142.55 linear regression AGE, SEX Albumin/Creatinine ratio at entry 7 8.58E-05 rs2350786 142.55 linear regression Albumin/Creatinine ratio at entry 7 9.43E-05 rs2350786 142.55 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 7 1.56E-04 rs2350786 142.55 linear regression GE Albumin/Creatinine ratio at entry 7 1.58E-04 rs13438289 147.47 linear regression AGE, SEX, GE Creatinine Clearance at entry 7 6.45E-05 rs13438289 147.47 linear regression AGE, SEX Creatinine Clearance at entry 7 9.48E-05 rs888576 0.08 linear regression GE Creatinine Clearance at entry 8 4.53E-04

rs7844524 15.10 linear regression AGE ₁ SEX Creatinine Clearance at entry 8 1.49E-04 rs7844524 15.10 linear regression AGE, SEX, GE Creatinine Clearance at entry 8 3.54E-04 rs1689871 35.05 linear regression AGE, SEX, GE Creatinine Clearance at entry 8 1.74E-04 rs1689871 35.05 linear regression AGE, SEX Creatinine Clearance at entry 8 2.00E-04 rs1689871 35.05 linear regression Creatinine Clearance at entry 8 3.43E-04 rs1689871 35.05 linear regression GE Creatinine Clearance at entry 8 3.55E-04 rs2717739 37.18 linear regression GE Albumin/Creatinine ratio at entry 8 3.11 E-04 rs2717739 37.18 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 8 3.87E-04 rs6557912 51.69 linear regression AGE, SEX, GE Creatinine Clearance at entry 8 4.22E-06 rs6557912 51.69 linear regression AGE ₁ SEX Creatinine Clearance at entry 8 1.53E-05 rs6557912 51.69 linear regression Creatinine Clearance at entry 8 1.01 E-04 rs6557912 51.69 linear regression GE Creatinine Clearance at entry 8 1.02E-04 rs2385127 66.17 linear regression AGE, SEX, GE Creatinine Clearance at entry 8 2.24E-04 rs2385127 66.17 linear regression AGE, SEX Creatinine Clearance at entry 8 2.69E-04 rs6990871 66.19 linear regression AGE, SEX, GE Creatinine Clearance at entry 8 4.83E-04 rs17722044 66.21 linear regression AGE, SEX, GE Creatinine Clearance at entry 8 3.22E-04 rs1519826 66.25 linear regression GE Creatinine Clearance at entry 8 7.38E-05 o, rs1519826 66.25 linear regression Creatinine Clearance at entry 8 7.96E-05

^ rs1519826 66.25 linear regression AGE, SEX, GE Creatinine Clearance at entry 8 3.38E-04 rs13279658 66.34 linear regression GE Creatinine Clearance at entry 8 9.24E-05 rs13279658 66.34 linear regression Creatinine Clearance at entry 8 9.52E-05 rs10808772 66.34 linear regression GE Creatinine Clearance at entry 8 9.67E-05 rs10808772 66.34 linear regression Creatinine Clearance at entry 8 1.02E-04 rs1845255 79.39 linear regression GE Albumin/Creatinine ratio at entry 8 4.05E-04 rs1845255 79.39 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 8 4.23E-04 rs16931308 81.21 linear regression AGE, SEX Albumin/Creatinine ratio at entry 8 2.56E-04 rs16931308 81.21 linear regression Albumin/Creatinine ratio at entry 8 2.68E-04 rs12543318 101.89 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 8 1.66E-04 rs12543318 101.89 linear regression GE Albumin/Creatinine ratio at entry 8 2.03E-04 rs12543318 101.89 linear regression AGE, SEX Albumin/Creatinine ratio at entry 8 2.07E-04 rs12543318 101.89 linear regression Albumin/Creatinine ratio at entry 8 2.40E-04 rs7012070 107.65 linear regression GE Creatinine Clearance at entry 8 6.30E-05 rs7012070 107.65 linear regression Creatinine Clearance at entry 8 6.52E-05 rs2704261 108.07 linear regression Creatinine Clearance at entry 8 2.08E-04 rs2704261 108.07 linear regression GE Creatinine Clearance at entry 8 2.22E-04 rs2704259 108.07 linear regression Creatinine Clearance at entry 8 3.76E-04

rs2704259 108.07 linear regression GE Creatinine Clearance at entry 8 4.02E-04 rs2059943 118.87 linear regression AGE ₁ SEX Creatinine Clearance at entry 8 4.71 E-04 rs2059943 118.87 linear regression AGE, SEX, GE Creatinine Clearance at entry 8 4.73E-04 rs2345070 118.87 linear regression AGE, SEX, GE Creatinine Clearance at entry 8 3.58E-04 rs2345070 118.87 linear regression AGE, SEX Creatinine Clearance at entry 8 3.65E-04 rs736627 118.90 linear regression AGE, SEX, GE Creatinine Clearance at entry 8 1.52E-04 rs736627 118.90 linear regression AGE, SEX Creatinine Clearance at entry 8 1.88E-04 rs1429675 118.90 linear regression AGE, SEX, GE Creatinine Clearance at entry 8 9.03E-05 rs1429675 118.90 linear regression AGE, SEX Creatinine Clearance at entry 8 1.23E-04 rs16887282 124.33 linear regression GE Albumin/Creatinine ratio at entry 8 1.44E-04 rs16887282 124.33 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 8 1.64E-04 rs16887282 124.33 linear regression Albumin/Creatinine ratio at entry 8 1.66E-04 rs16887282 124.33 linear regression AGE, SEX Albumin/Creatinine ratio at entry 8 1.87E-04 rs 1464611 128.58 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 8 4.21 E-04 rs1464611 128.58 linear regression GE Albumin/Creatinine ratio at entry 8 4.94E-04 rs17370786 130.22 linear regression Creatinine Clearance at entry 8 1.04E-04 rs17370786 130.22 linear regression GE Creatinine Clearance at entry 8 1.13E-04 rs2436139 145.60 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 8 3.11 E-04 rs2436139 145.60 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 8 4.13E-04 rs2436140 145.60 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 8 2.54E-04 rs2436140 145.60 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 8 2.57E-04 rs2436140 145.60 linear regression Albumin/Creatinine ratio at entry 8 4.48E-04 rs6651259 145.62 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 8 4.23E-04 rs6651259 145.62 linear regression AGE, SEX Albumin/Creatinine ratio at entry 8 4.76E-04 rs3779972 145.63 linear regression AGE, SEX Albumin/Creatinine ratio at entry 8 2.33E-04 rs3779972 145.63 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 8 3.21 E-04 rs3779972 145.63 linear regression Albumin/Creatinine ratio at entry 8 3.81 E-04 rs7033145 8.18 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 9 3.80E-04 rs11791772 8.73 linear regression AGE, SEX Creatinine Clearance at entry 9 1.29E-04 rs11791772 8.73 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 9 1.60E-04 rs605257 21.40 linear regression Creatinine Clearance at entry 9 4.35E-04 rs605257 21.40 linear regression GE Creatinine Clearance at entry 9 4.37E-04 rs1008981 21.81 linear regression AGE, SEX Creatinine Clearance at entry 9 2.24E-04 rs1008981 21.81 linear regression AGE, SEX, GE Creatinine Clearance at entry 9 2.73E-04 rs10959227 22.32 linear regression AGE, SEX, GE Creatinine Clearance at entry 9 7.72E-05 rs10959227 22.32 linear regression AGE, SEX Creatinine Clearance at entry 9 9.68E-05

rs10738180 22.32 linear regression AGE, SEX, GE Creatinine Clearance at entry 9 2.28E-04 rs10738180 22.32 linear regression AGE, SEX Creatinine Clearance at entry 9 2.49E-04 rs579392 32.64 linear regression AGE, SEX Albumin/Creatinine ratio at entry 9 1.36E-04 rs579392 32.64 linear regression Albumin/Creatinine ratio at entry 9 1.59E-04 rs10812342 46.56 linear regression GE Creatinine Clearance at entry 9 4.38E-04 rs1169752 52.72 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 9 4.12E-04 rs1169750 52.72 linear regression AGE, SEX Albumin/Creatinine ratio at entry 9 3.76E-04 rs11145647 77.80 linear regression GE Creatinine Clearance at entry 9 3.48E-04 rs11145647 77.80 linear regression Creatinine Clearance at entry 9 3.50E-04 rs7047415 102.50 linear regression GE Albumin/Creatinine ratio at entry 9 4.22E-07 rs7047415 102.50 linear regression Albumin/Creatinine ratio at entry 9 4.90E-07 rs7047415 102.50 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 9 7.39E-07 rs7047415 102.50 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 9 7.41 E-07 rs7029315 102.50 linear regression GE Albumin/Creatinine ratio at entry 9 3.15E-07 rs7029315 102.50 linear regression Albumin/Creatinine ratio at entry 9 3.63E-07 rs7029315 102.50 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 9 5.22E-07 rs7029315 102.50 linear regression AGE, SEX Albumin/Creatinine ratio at entry 9 5.24E-07 rs16910240 102.50 linear regression GE Albumin/Creatinine ratio at entry 9 4.10E-07

VO rs16910240 102.50 linear regression Albumin/Creatinine ratio at entry 9 4.93E-07 rs16910240 102.50 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 9 7.06E-07 rs16910240 102.50 linear regression AGE, SEX Albumin/Creatinine ratio at entry 9 7.44E-07 rs11793735 103.54 linear regression GE Creatinine Clearance at entry 9 1.26E-04 rs11793735 103.54 linear regression Creatinine Clearance at entry 9 1.38E-04 rs11793735 103.54 linear regression AGE, SEX Creatinine Clearance at entry 9 3.22E-04 rs11793735 103.54 linear regression AGE, SEX, GE Creatinine Clearance at entry 9 4.01 E-04 rs1628249 105.24 linear regression AGE, SEX Creatinine Clearance at entry 9 3.40E-04 rs1628249 105.24 linear regression AGE, SEX, GE Creatinine Clearance at entry 9 4.72E-04 rs2740485 110.56 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 9 6.11 E-05 rs2740485 110.56 linear regression Albumin/Creatinine ratio at entry 9 6.17E-05 rs2740485 110.56 linear regression GE . Albumin/Creatinine ratio at entry 9 1.38E-04 rs2740485 110.56 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 9 1.58E-04 rs3739455 117.58 linear regression Albumin/Creatinine ratio at entry 9 1.27E-04 rs3739455 117.58 linear regression AGE, SEX Albumin/Creatinine ratio at entry 9 1.60E-04 rs3739455 117.58 linear regression GE Albumin/Creatinine ratio at entry 9 2.96E-04 rs3739455 117.58 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 9 4.26E-04 rs10980324 117.72 linear regression GE Albumin/Creatinine ratio at entry 9 3.76E-04

rs10982727 123.56 linear regression Albumin/Creatinine ratio at entry 9 2.03E-04 rs10982727 123.56 linear regression AGE, SEX Albumin/Creatinine ratio at entry 9 2.77E-04 rs10982727 123.56 linear regression GE Albumin/Creatinine ratio at entry 9 4.73E-04 rs996492 123.57 linear regression Albumin/Creatinine ratio at entry 9 3.37E-04 rs996492 123.57 linear regression AGE, SEX Albumin/Creatinine ratio at entry 9 4.89E-04 rs184255 131.45 linear regression Albumin/Creatinine ratio at entry 9 6.84E-07 rs184255 131.45 linear regression AGE, SEX Albumin/Creatinine ratio at entry 9 8.74E-07 rs184255 131.45 linear regression GE Albumin/Creatinine ratio at entry 9 2.48E-06 rs184255 131.45 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 9 3.83E-06 rs6478513 131.50 linear regression Albumin/Creatinine ratio at entry 9 6.93E-07 rs6478513 131.50 linear regression AGE, SEX Albumin/Creatinine ratio at entry 9 8.86E-07 rs6478513 131.50 linear regression GE Albumin/Creatinine ratio at entry 9 2.51 E-06 rs6478513 131.50 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 9 3.88E-06 rs17272567 137.85 linear regression GE Creatinine Clearance at entry 9 4.69E-04 rs17272567 137.85 linear regression Creatinine Clearance at entry 9 4.86E-04 rs10987266 138.03 linear regression AGE, SEX Creatinine Clearance at entry 9 1.18E-04 rs10987266 138.03 linear regression AGE, SEX, GE Creatinine Clearance at entry 9 1.53E-04 rs17539168 144.40 linear regression GE Albumin/Creatinine ratio at entry 9 3.41 E-04 eon rs17539168 144.40 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 9 4.33E-04 rs12375830 144.41 linear regression GE Albumin/Creatinine ratio at entry 9 4.51 E-04 rs11253517 2.34 linear regression AGE, SEX Creatinine Clearance at entry 10 1.17E-04 rs11253517 2.34 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 1.93E-04 rs1539174 2.34 linear regression AGE, SEX Creatinine Clearance at entry 10 2.20E-04 rs1539174 2.34 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 3.30E-04 rs4444002 3.45 linear regression AGE, SEX Albumin/Creatinine ratio at entry 10 2.17E-04 rs4444002 3.45 linear regression Albumin/Creatinine ratio at entry 10 2.23E-04 rs4444002 3.45 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 10 2.67E-04 rs4444002 3.45 linear regression GE Albumin/Creatinine ratio at entry 10 2.85E-04 rs4749929 28.00 linear regression Albumin/Creatinine ratio at entry 10 4.20E-05 rs4749929 28.00 linear regression GE Albumin/Creatinine ratio at entry 10 4.55E-05 rs4749929 28.00 linear regression AGE, SEX Albumin/Creatinine ratio at entry 10 6.03E-05 rs4749929 28.00 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 10 7.13E-05 rs7087063 29.75 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 10 1.65E-04 rs7087063 29.75 linear regression AGE, SEX Creatinine Clearance at entry 10 2.12E-04 rs2378991 29.76 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 3.31 E-04 rs2378991 29.76 linear regression AGE, SEX Creatinine Clearance at entry 10 3.77E-04

rs1124487 47.23 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 2.57E-04 rs1124487 47.23 linear regression AGE, SEX Creatinine Clearance at entry 10 4.62E-04 rs16922762 48.47 linear regression GE Albumin/Creatinine ratio at entry 10 1.84E-04 rs16922762 48.47 linear regression Albumin/Creatinine ratio at entry 10 1.88E-04 rs16922762 48.47 linear regression AGE, SEX Albumin/Creatinine ratio at entry 10 1.92E-04 rs16922762 48.47 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 10 1.98E-04 rs11013381 48.73 linear regression Creatinine Clearance at entry 10 2.15E-04 rs11013381 48.73 linear regression GE Creatinine Clearance at entry 10 2.32E-04 rs10509120 78.50 linear regression Albumin/Creatinine ratio at entry 10 3.54E-04 rs10509120 78.50 linear regression AGE, SEX Albumin/Creatinine ratio at entry 10 3.76E-04 rs4746746 80.61 linear regression AGE, SEX Creatinine Clearance at entry 10 4.16E-04 rs4147153 80.62 linear regression AGE, SEX Creatinine Clearance at entry 10 4.38E-04 rs1571918 80.62 linear regression AGE, SEX Creatinine Clearance at entry 10 4.38E-04 rs827282 91.46 linear regression Creatinine Clearance at entry 10 3.22E-04 rs827282 91.46 linear regression GE Creatinine Clearance at entry 10 3.36E-04 rs12220179 98.39 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 3.97E-04 rs4979805 99.56 linear regression AGE, SEX Albumin/Creatinine ratio at entry 10 4.36E-04 a, rs4979805 99.56 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 10 4.68E-04

2 rs4979805 99.56 linear regression Albumin/Creatinine ratio at entry 10 4.88E-04 rs12411806 102.56 linear regression AGE, SEX Albumin/Creatinine ratio at entry 10 3.93E-04 rs12411806 102.56 linear regression Albumin/Creatinine ratio at entry 10 4.50E-04 rs1416847 104.17 linear regression AGE, SEX Creatinine Clearance at entry 10 2.50E-04 rs1416847 104.17 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 2.57E-04 rs17100442 104.19 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 1.73E-04 rs17100442 104.19 linear regression AGE, SEX Creatinine Clearance at entry 10 1.84E-04 rs1912278 106.28 linear regression GE Albumin/Creatinine ratio at entry 10 3.66E-04 rs1912278 106.28 linear regression Albumin/Creatinine ratio at entry 10 3.71 E-04 rs1912278 106.28 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 10 3.84E-04 rs1912278 106.28 linear regression AGE, SEX Albumin/Creatinine ratio at entry 10 4.03E-04 rs1240385 107.37 linear regression Albumin/Creatinine ratio at entry 10 6.30E-05 rs1240385 107.37 linear regression AGE, SEX Albumin/Creatinine ratio at entry 10 6.35E-05 rs1240385 107.37 linear regression GE Albumin/Creatinine ratio at entry 10 7.25E-05 rs1240385 107.37 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 10 7.60E-05 rs11191734 125.23 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 10 3.89E-04 rs11191734 125.23 linear regression GE Albumin/Creatinine ratio at entry 10 4.16E-04 rs4917579 129.38 linear regression Creatinine Clearance at entry 10 4.88E-04

rs12218901 129.38 linear regression Creatinine Clearance at entry 10 2.73E-04 rs12218901 129.38 linear regression GE Creatinine Clearance at entry 10 3.06E-04 rs11195266 129.39 linear regression Creatinine Clearance at entry 10 3.17E-04 rs11195266 129.39 linear regression GE Creatinine Clearance at entry 10 3.52E-04 rs10509929 129.43 linear regression GE Creatinine Clearance at entry 10 3.22E-05 rs10509929 129.43 linear regression Creatinine Clearance at entry 10 3.39E-05 rs10509929 129.43 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 3.19E-04 rs11195288 129.43 linear regression GE Creatinine Clearance at entry 10 9.02E-05 rs11195288 129.43 linear regression Creatinine Clearance at entry 10 9.39E-05 rs4444012 132.16 linear regression AGE, SEX Creatinine Clearance at entry 10 3.78E-04 rs4444012 132.16 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 4.00E-04 rs2039709 132.19 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 4.77E-04 rs6585252 132.90 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 1.78E-04 rs6585252 132.90 linear regression Creatinine Clearance at entry 10 2.11E-04 rs6585252 132.90 linear regression AGE, SEX Creatinine Clearance at entry 10 2.12E-04 rs6585252 132.90 linear regression GE Creatinine Clearance at entry 10 2.27E-04 rs11196566 132.90 linear regression Creatinine Clearance at entry 10 8.64E-05 rs11196566 132.90 linear regression GE Creatinine Clearance at entry 10 8.97E-05 eκn> rs11196566 132.90 linear regression AGE, SEX Creatinine Clearance at entry 10 1.06E-04 rs11196566 132.90 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 1.09E-04 rs17152806 151.35 linear regression AGE, SEX Creatinine Clearance at entry 10 4.75E-04 rs549879 161.47 linear regression AGE, SEX, GE Creatinine Clearance at entry 10 2.36E-04 rs549879 161.47 linear regression AGE, SEX Creatinine Clearance at entry 10 3.58E-04 rs527384 162.66 linear regression Creatinine Clearance at entry 10 2.94E-04 rs527384 162.66 linear regression GE Creatinine Clearance at entry 10 3.22E-04 rs6416094 17.97 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 3.51 E-04 rs7123301 21.27 linear regression AGE, SEX Creatinine Clearance at entry 11 4.98E-04 rs764848 47.75 linear regression AGE, SEX Creatinine Clearance at entry 11 5.05E-05 rs764848 47.75 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 5.77E-05 rs4315060 51.44 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 11 1.52E-04 rs4315060 51.44 linear regression GE Albumin/Creatinine ratio at entry 11 1.97E-04 rs4315060 51.44 linear regression AGE, SEX Albumin/Creatinine ratio at entry 11 3.64E-04 rs4315060 51.44 linear regression Albumin/Creatinine ratio at entry 11 4.20E-04 rs10742654 53.65 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 11 3.91 E-04 rs7926119 53.65 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 11 4.45E-04 rs12361863 84.32 linear regression AGE, SEX Albumin/Creatinine ratio at entry 11 2.76E-04

rs12361863 84.32 linear regression Albumin/Creatinine ratio at entry 11 3.69E-04 rs11232346 84.33 linear regression AGE, SEX Albumin/Creatinine ratio at entry 11 1.07E-04 rs11232346 84.33 linear regression Albumin/Creatinine ratio at entry 11 1.26E-04 rs11232346 84.33 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 11 2.08E-04 rs11232346 84.33 linear regression GE Albumin/Creatinine ratio at entry 11 2.29E-04 rs1216192 98.01 linear regression Albumin/Creatinine ratio at entry 11 2.77E-04 rs1216192 98.01 linear regression AGE, SEX Albumin/Creatinine ratio at entry 11 2.94E-04 rs1216192 98.01 linear regression GE Albumin/Creatinine ratio at entry 11 3.73E-04 rs1216192 98.01 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 11 4.17E-04 rs1545860 99.71 linear regression Creatinine Clearance at entry 11 2.30E-04 rs1545860 99.71 linear regression GE Creatinine Clearance at entry 11 2.57E-04 rs473689 99.72 linear regression Creatinine Clearance at entry 11 3.55E-04 rs473689 99.72 linear regression GE Creatinine Clearance at entry 11 3.99E-04 rs4583006 103.25 linear regression GE Creatinine Clearance at entry 11 3.28E-04 rs4583006 103.25 linear regression Creatinine Clearance at entry 11 3.37E-04 rs17626940 106.29 linear regression AGE, SEX Creatinine Clearance at entry 11 2.92E-05 rs17626940 106.29 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 3.43E-05 rs6589403 106.31 linear regression AGE, SEX Creatinine Clearance at entry 11 4.38E-05

Ul rs6589403 106.31 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 4.88E-05 rs10891623 106.31 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 3.10E-04 rs10891623 106.31 linear regression AGE, SEX Creatinine Clearance at entry 11 4.12E-04 rs636577 107.29 linear regression AGE, SEX Creatinine Clearance at entry 11 1.33E-04 rs636577 107.29 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 2.12E-04 rs620095 107.34 linear regression AGE, SEX Creatinine Clearance at entry 11 1.13E-04 rs620095 107.34 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 1.33E-04 rs420234 107.47 linear regression AGE, SEX Creatinine Clearance at entry 11 7.65E-05 rs420234 107.47 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 1.64E-04 rs590843 116.05 linear regression Creatinine Clearance at entry 11 2.65E-04 rs590843 116.05 linear regression GE Creatinine Clearance at entry 11 2.89E-04 rs470392 116.06 linear regression Creatinine Clearance at entry 11 2.97E-04 rs470392 116.06 linear regression GE Creatinine Clearance at entry 11 3.20E-04 rs494965 116.14 linear regression AGE, SEX Creatinine Clearance at entry 11 4.53E-04 rs2508492 116.15 linear regression AGE, SEX Albumin/Creatinine ratio at entry 11 1.18E-04 rs2508492 116.15 linear regression Albumin/Creatinine ratio at entry 11 1.26E-04 rs2508492 116.15 linear regression GE Albumin/Creatinine ratio at entry 11 4.15E-04 rs2508492 116.15 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 11 4.40E-04

rs493642 120.58 linear regression AGE, SEX Creatinine Clearance at entry 11 1.27E-04 rs493642 120.58 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 3.86E-04 rs479000 120.58 linear regression AGE, SEX Creatinine Clearance at entry 11 3.71 E-05 rs479000 120.58 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 1.15E-04 rs479000 120.58 linear regression GE Creatinine Clearance at entry 11 4.07E-04 rs479000 120.58 linear regression Creatinine Clearance at entry 11 4.29E-04 rs6421609 136.90 linear regression AGE, SEX Creatinine Clearance at entry 11 4.84E-04 rs10894277 136.90 linear regression AGE, SEX Creatinine Clearance at entry 11 3.62E-04 rs10894277 136.90 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 4.63E-04 rs3794139 136.91 linear regression AGE, SEX Creatinine Clearance at entry 11 4.75E-05 rs3794139 136.91 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 6.67E-05 rs3794139 136.91 linear regression Creatinine Clearance at entry 11 1.57E-04 rs3794139 136.91 linear regression GE Creatinine Clearance at entry 11 1.61E-04 rs3829270 136.91 linear regression AGE, SEX Creatinine Clearance at entry 11 5.78E-05 rs3829270 136.91 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 8.09E-05 rs3829270 136.91 linear regression Creatinine Clearance at entry 11 1.78E-04 rs3829270 136.91 linear regression GE Creatinine Clearance at entry 11 1.83E-04

^ rs10894280 136.92 linear regression AGE, SEX Creatinine Clearance at entry 11 4.92E-05

£ rs10894280 136.92 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 6.95E-05 rs10894280 136.92 linear regression Creatinine Clearance at entry 11 1.52E-04 rs10894280 136.92 linear regression GE Creatinine Clearance at entry 11 1.56E-04 rs10894281 136.92 linear regression AGE, SEX Creatinine Clearance at entry 11 4.94E-05 rs10894281 136.92 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 6.97E-05 rs10894281 136.92 linear regression Creatinine Clearance at entry 11 1.68E-04 rs10894281 136.92 linear regression GE Creatinine Clearance at entry 11 1.73E-04 rs3198419 136.92 linear regression AGE, SEX Creatinine Clearance at entry 11 5.13E-05 rs3198419 136.92 linear regression AGE, SEX, GE Creatinine Clearance at entry 11 7.21 E-05 rs3198419 136.92 linear regression Creatinine Clearance at entry 11 1.66E-04 rs3198419 136.92 linear regression GE Creatinine Clearance at entry 11 1.71E-04 rs7976757 36.00 linear regression AGE, SEX Creatinine Clearance at entry 12 4.72E-04 rs751082 36.06 linear regression GE Creatinine Clearance at entry 12 3.37E-04 rs751082 36.06 linear regression Creatinine Clearance at entry 12 4.00E-04 rs10841479 37.96 linear regression GE Albumin/Creatinine ratio at entry 12 2.97E-04 rs10841479 37.96 linear regression Albumin/Creatinine ratio at entry 12 3.06E-04 rs10841479 37.96 linear regression AGE, SEX Albumin/Creatinine ratio at entry 12 4.06E-04 rs10841479 37.96 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 12 4.26E-04

rs4762802 39.06 linear regression GE Creatinine Clearance at entry 12 4.27E-04 rs4762802 39.06 linear regression Creatinine Clearance at entry 12 4.33E-04 rs10842321 43.62 linear regression GE Albumin/Creatinine ratio at entry 12 2.66E-06 rs10842321 43.62 linear regression Albumin/Creatinine ratio at entry 12 3.31 E-06 rs10842321 43.62 linear regression AGE ₁ SEX, GE Albumin/Creatinine ratio at entry 12 4.96E-06 rs10842321 43.62 linear regression AGE, SEX Albumin/Creatinine ratio at entry 12 5.85E-06 rs11048977 48.39 linear regression GE Albumin/Creatinine ratio at entry 12 4.53E-04 rs11048977 48.39 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 12 4.90E-04 rs4931081 49.55 linear regression Albumin/Creatinine ratio at entry 12 3.52E-04 rs4931081 49.55 linear regression AGE, SEX Albumin/Creatinine ratio at entry 12 4.44E-04 rs4931086 49.66 linear regression Albumin/Creatinine ratio at entry 12 3.51 E-04 rs4931086 49.66 linear regression AGE, SEX Albumin/Creatinine ratio at entry 12 4.09E-04 rs1965193 52.71 linear regression AGE, SEX Creatinine Clearance at entry 12 1.75E-04 rs1965193 52.71 linear regression Creatinine Clearance at entry 12 1.80E-04 rs1965193 52.71 linear regression GE Creatinine Clearance at entry 12 1.91 E-04 rs1965193 52.71 linear regression AGE, SEX, GE Creatinine Clearance at entry 12 3.62E-04 rs17128987 55.36 linear regression AGE, SEX Albumin/Creatinine ratio at entry 12 4.04E-04 rs4329752 62.31 linear regression Creatinine Clearance at entry

Ul 12 5.57E-05 rs4329752 62.31 linear regression GE Creatinine Clearance at entry 12 5.70E-05 rs1468196 62.31 linear regression Creatinine Clearance at entry 12 9.77E-05 rs1468196 62.31 linear regression GE Creatinine Clearance at entry 12 1.05E-04 rs1468196 62.31 linear regression AGE, SEX Creatinine Clearance at entry 12 2.66E-04 rs1468196 62.31 linear regression AGE, SEX, GE Creatinine Clearance at entry 12 3.14E-04 rs17224336 62.32 linear regression Creatinine Clearance at entry 12 8.99E-05 rs17224336 62.32 linear regression GE Creatinine Clearance at entry 12 9.64E-05 rs17224336 62.32 linear regression AGE, SEX Creatinine Clearance at entry 12 2.45E-04 rs17224336 62.32 linear regression AGE, SEX, GE Creatinine Clearance at entry 12 2.87E-04 rs3741670 69.73 linear regression AGE, SEX Creatinine Clearance at entry 12 1.89E-04 rs3741670 69.73 linear regression AGE, SEX, GE Creatinine Clearance at entry 12 4.80E-04 rs11834651 72.18 linear regression GE Albumin/Creatinine ratio at entry 12 1.43E-04 rs11834651 72.18 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 12 1.68E-04 rs11609178 94.08 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 12 2.80E-04 rs11609178 94.08 linear regression GE Albumin/Creatinine ratio at entry 12 3.46E-04 rs11609178 94.08 linear regression AGE, SEX Albumin/Creatinine ratio at entry 12 4.97E-04 rs10492295 94.10 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 12 1.45E-04 rs10492295 94.10 linear regression GE Albumin/Creatinine ratio at entry 12 2.58E-04

rs10492295 94.10 linear regression AGE, SEX Albumin/Creatinine ratio at entry 12 2.89E-04 rs10492295 94.10 linear regression Albumin/Creatinine ratio at entry 12 4.41 E-04 rs17025028 100.73 linear regression AGE, SEX, GE Creatinine Clearance at entry 12 4.70E-04 rs6538697 100.74 linear regression AGE, SEX, GE Creatinine Clearance at entry 12 3.54E-04 rs7296106 100.74 linear regression AGE, SEX, GE Creatinine Clearance at entry 12 3.61 E-04 rs2114913 108.91 linear regression AGE, SEX Albumin/Creatinine ratio at entry 12 8.97E-06 rs2114913 108.91 linear regression Albumin/Creatinine ratio at entry 12 1.42E-05 rs2114913 108.91 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 12 4.57E-05 rs2114913 108.91 linear regression GE Albumin/Creatinine ratio at entry 12 6.06E-05 rs1726392 133.38 linear regression GE Albumin/Creatinine ratio at entry 12 2.92E-04 rs1726392 133.38 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 12 4.05E-04 rs2942076 138.71 linear regression AGE, SEX, GE Creatinine Clearance at entry 12 2.01 E-04 rs2942076 138.71 linear regression AGE, SEX Creatinine Clearance at entry 12 2.58E-04 rs225518 146.83 linear regression Albumin/Creatinine ratio at entry 12 3.71 E-04 rs345677 150.28 linear regression AGE, SEX Creatinine Clearance at entry 12 3.65E-04 rs345677 150.28 linear regression AGE, SEX, GE Creatinine Clearance at entry 12 4.86E-04 rs7953620 152.84 linear regression Creatinine Clearance at entry 12 1.99E-04 rs7953620 152.84 linear regression GE Creatinine Clearance at entry 12 2.08E-04

Ul

Os rs10773546 153.27 linear regression AGE, SEX Creatinine Clearance at entry 12 1.95E-04 rs10773546 153.27 linear regression AGE, SEX, GE Creatinine Clearance at entry 12 2.53E-04 rs7138576 153.27 linear regression AGE, SEX Creatinine Clearance at entry 12 1.56E-04 rs7138576 153.27 linear regression AGE, SEX, GE Creatinine Clearance at entry 12 2.04E-04 rs11060812 163.40 linear regression Albumin/Creatinine ratio at entry 12 4.77E-04 rs4883520 168.24 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 12 4.24E-04 rs4883520 168.24 linear regression GE. Albumin/Creatinine ratio at entry 12 4.44E-04 rs4883520 168.24 linear regression Albumin/Creatinine ratio at entry 12 4.68E-04 rs4883520 168.24 linear regression AGE, SEX Albumin/Creatinine ratio at entry 12 4.71 E-04 rs2313862 6.11 linear regression Albumin/Creatinine ratio at entry 13 3.12E-04 rs2313862 6.11 linear regression AGE, SEX Albumin/Creatinine ratio at entry 13 4.92E-04 rs530991 13.24 linear regression AGE, SEX, GE Creatinine Clearance at entry 13 4.18E-05 rs530991 13.24 linear regression AGE, SEX Creatinine Clearance at entry 13 7.18E-05 rs545865 13.25 linear regression AGE, SEX, GE Creatinine Clearance at entry 13 1.58E-04 rs545865 13.25 linear regression AGE, SEX Creatinine Clearance at entry 13 2.59E-04 rs1571317 29.57 linear regression Albumin/Creatinine ratio at entry 13 1.09E-04 rs1571317 29.57 linear regression AGE, SEX Albumin/Creatinine ratio at entry 13 1.23E-04 rs1571317 29.57 linear regression GE Albumin/Creatinine ratio at entry 13 2.14E-04

rs1571317 29.57 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 13 2.56E-04 rs9315454 29.59 linear regression Albumin/Creatinine ratio at entry 13 1.68E-04 rs9315454 29.59 linear regression AGE, SEX Albumin/Creatinine ratio at entry 13 1.95E-04 rs9315454 29.59 linear regression GE Albumin/Creatinine ratio at entry 13 2.16E-04 rs9315454 29.59 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 13 2.54E-04 rs6563629 33.25 linear regression GE Creatinine Clearance at entry 13 1.53E-04 rs6563629 33.25 linear regression Creatinine Clearance at entry 13 1.66E-04 rs6563629 33.25 linear regression AGE, SEX, GE Creatinine Clearance at entry 13 2.23E-04 rs6563629 33.25 linear regression AGE, SEX Creatinine Clearance at entry 13 2.43E-04 rs2122208 33.25 linear regression GE Creatinine Clearance at entry 13 7.86E-05 rs2122208 33.25 linear regression Creatinine Clearance at entry 13 8.47E-05 rs2122208 33.25 linear regression AGE, SEX, GE Creatinine Clearance at entry 13 1.24E-04 rs2122208 33.25 linear regression AGE, SEX Creatinine Clearance at entry 13 1.38E-04 rs2197879 33.26 linear regression GE Creatinine Clearance at entry 13 3.31E-05 rs2197879 33.26 linear regression Creatinine Clearance at entry 13 3.56E-05 rs2197879 33.26 linear regression AGE, SEX, GE Creatinine Clearance at entry 13 1.24E-04 rs2197879 33.26 linear regression AGE, SEX Creatinine Clearance at entry 13 1.37E-04 rs2496425 33.29 linear regression GE Creatinine Clearance at entry 13 1.34E-04

Ul rs2496425 33.29 linear regression AGE, SEX, GE Creatinine Clearance at entry 13 1.36E-04 rs2496425 33.29 linear regression Creatinine Clearance at entry 13 1.45E-04 rs2496425 33.29 linear regression AGE, SEX Creatinine Clearance at entry 13 1.56E-04 rs2026692 44.37 linear regression Albumin/Creatinine ratio at entry 13 2.20E-04 rs2026692 44.37 linear regression AGE, SEX Albumin/Creatinine ratio at entry 13 2.65E-04 rs2026692 44.37 linear regression GE Albumin/Creatinine ratio at entry 13 4.02E-04 rs3895563 48.02 linear regression GE Albumin/Creatinine ratio at entry 13 1.42E-04 rs3895563 48.02 linear regression Albumin/Creatinine ratio at entry 13 1.79E-04 rs3895563 48.02 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 13 1.86E-04 rs3895563 48.02 linear regression AGE, SEX Albumin/Creatinine ratio at entry 13 2.13E-04 rs483023 49.51 linear regression AGE, SEX, GE Creatinine Clearance at entry 13 6.44E-05 rs483023 49.51 linear regression AGE, SEX Creatinine Clearance at entry 13 1.33E-04 rs693439 49.51 linear regression AGE, SEX, GE Creatinine Clearance at entry 13 1.10E-04 rs693439 49.51 linear regression AGE, SEX Creatinine Clearance at entry 13 2.06E-04 rs11838823 49.51 linear regression AGE, SEX, GE Creatinine Clearance at entry 13 6.61 E-05 rs11838823 49.51 linear regression AGE, SEX Creatinine Clearance at entry 13 1.33E-04 rs617215 49.52 linear regression AGE, SEX, GE Creatinine Clearance at entry 13 9.96E-05 rs617215 49.52 linear regression AGE, SEX Creatinine Clearance at entry 13 1.94E-04

rs17080594 50.39 linear regression GE Albumin/Creatinine ratio at entry 13 4.53E-04 rs7139910 50.42 linear regression GE Albumin/Creatinine ratio at entry 13 2.81 E-04 rs7139910 50.42 linear regression Albumin/Creatinine ratio at entry 13 3.25E-04 rs7139910 50.42 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 13 3.33E-04 rs7139910 50.42 linear regression AGE, SEX Albumin/Creatinine ratio at entry 13 3.67E-04 rs9599174 51.06 linear regression GE Creatinine Clearance at entry 13 3.90E-04 rs9599174 51.06 linear regression Creatinine Clearance at entry 13 4.19E-04 rs1937076 52.68 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 13 3.90E-04 rs1937076 52.68 linear regression GE Albumin/Creatinine ratio at entry 13 4.63E-04 rs9542982 53.50 linear regression GE Creatinine Clearance at entry 13 2.32E-05 rs9542982 53.50 linear regression Creatinine Clearance at entry 13 2.42E-05 rs7332804 65.33 linear regression GE Albumin/Creatinine ratio at entry 13 4.67E-04 rs7332804 65.33 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 13 4.79E-04 rs7332804 65.33 linear regression Albumin/Creatinine ratio at entry 13 4.81 E-04 rs7332804 65.33 linear regression AGE, SEX Albumin/Creatinine ratio at entry 13 4.93E-04 rs4773558 68.70 linear regression GE Albumin/Creatinine ratio at entry 13 4.64E-04 rs9518171 82.70 linear regression AGE, SEX, GE Creatinine Clearance at entry 13 4.63E-04 rs7331453 84.61 linear regression GE Creatinine Clearance at entry 13 1.84E-04 rs7331453 84.61 linear regression Creatinine Clearance at entry 13 1.99E-04 rs8011308 11.47 linear regression AGE, SEX Creatinine Clearance at entry 14 3.94E-04 rs17113090 26.81 linear regression AGE, SEX Creatinine Clearance at entry 14 4.57E-04 rs17113090 26.81 linear regression AGE, SEX, GE Creatinine Clearance at entry 14 4.82E-04 rs8005269 38.56 linear regression AGE, SEX Albumin/Creatinine ratio at entry 14 3.17E-04 rs8005269 38.56 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 14 4.88E-04 rs17508334 41.69 linear regression Albumin/Creatinine ratio at entry 14 2.66E-04 rs17508334 41.69 linear regression AGE, SEX Albumin/Creatinine ratio at entry 14 2.86E-04 rs17508334 41.69 linear regression GE Albumin/Creatinine ratio at entry 14 3.35E-04 rs17508334 41.69 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 14 3.58E-04 rs2073623 53.60 linear regression Albumin/Creatinine ratio at entry 14 4.44E-04 rs2073623 53.60 linear regression AGE, SEX Albumin/Creatinine ratio at entry 14 4.63E-04 rs10129357 68.46 linear regression AGE, SEX, GE Creatinine Clearance at entry 14 3.06E-04 rs10129357 68.46 linear regression AGE, SEX Creatinine Clearance at entry 14 3.58E-04 rs17751454 68.94 linear regression Creatinine Clearance at entry 14 7.33E-05 rs17751454 68.94 linear regression GE Creatinine Clearance at entry 14 8.37E-05 rs7161192 68.95 linear regression Creatinine Clearance at entry 14 1.99E-04 rs7161192 68.95 linear regression GE Creatinine Clearance at entry 14 2.11 E-04

rs723432 71.77 linear regression AGE, SEX Creatinine Clearance at entry 14 4.60E-04 rs17248895 72.40 linear regression AGE, SEX Creatinine Clearance at entry 14 4.86E-04 rs8021730 72.40 linear regression AGE, SEX Creatinine Clearance at entry 14 2.32E-04 rs8021730 72.40 linear regression AGE, SEX, GE Creatinine Clearance at entry 14 3.65E-04 rs17178883 78.32 linear regression Creatinine Clearance at entry 14 1.07E-04 rs17178883 78.32 linear regression GE Creatinine Clearance at entry 14 1.12E-04 rs2109273 78.33 linear regression Creatinine Clearance at entry 14 1.53E-04 rs2109273 78.33 linear regression GE Creatinine Clearance at entry 14 1.58E-04 rs8003168 78.33 linear regression Creatinine Clearance at entry 14 3.63E-05 rs8003168 78.33 linear regression GE Creatinine Clearance at entry 14 3.67E-05 rs11629078 78.33 linear regression Creatinine Clearance at entry 14 5.20E-05 rs11629078 78.33 linear regression GE Creatinine Clearance at entry 14 5.36E-05 rs2191644 93.62 linear regression AGE, SEX Creatinine Clearance at entry 14 2.52E-04 rs2191644 93.62 linear regression AGE, SEX, GE Creatinine Clearance at entry 14 3.95E-04 rs4904333 93.62 linear regression AGE, SEX Creatinine Clearance at entry 14 2.54E-04 rs4904333 93.62 linear regression AGE, SEX, GE Creatinine Clearance at entry 14 4.01 E-04 rs8012459 93.75 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 14 2.15E-04 rs8012459 93.75 linear regression GE Albumin/Creatinine ratio at entry 14 2.65E-04

Ul rs8012459 93.75 linear regression AGE, SEX Albumin/Creatinine ratio at entry 14 2.78E-04 rs8012459 93.75 linear regression Albumin/Creatinine ratio at entry 14 3.26E-04 rs4778549 4.52 linear regression Albumin/Creatinine ratio at entry 15 3.97E-04 rs4778549 4.52 linear regression AGE, SEX Albumin/Creatinine ratio at entry 15 4.11 E-04 rs4778549 4.52 linear regression GE Albumin/Creatinine ratio at entry 15 4.20E-04 rs4778549 4.52 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 15 4.52E-04 rs12904911 4.52 linear regression Albumin/Creatinine ratio at entry 15 3.01 E-04 rs12904911 4.52 linear regression GE Albumin/Creatinine ratio at entry 15 3.34E-04 rs12904911 4.52 linear regression AGE, SEX Albumin/Creatinine ratio at entry 15 3.76E-04 rs12904911 4.52 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 15 4.63E-04 rs974849 33.47 linear regression AGE, SEX Albumin/Creatinine ratio at entry 15 8.93E-05 rs974849 33.47 linear regression Albumin/Creatinine ratio at entry 15 1.01 E-04 rs974849 33.47 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 15 1.29E-04 rs974849 33.47 linear regression GE Albumin/Creatinine ratio at entry 15 1.43E-04 rs12595466 33.52 linear regression AGE, SEX Albumin/Creatinine ratio at entry 15 4.25E-04 rs12595466 33.52 linear regression Albumin/Creatinine ratio at entry 15 4.72E-04 rs12595466 33.52 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 15 4.96E-04 rs8024417 33.54 linear regression AGE, SEX Albumin/Creatinine ratio at entry 15 4.32E-04

rs8024417 33.54 linear regression Albumin/Creatinine ratio at entry 15 4.75E-04 rs35390951 37.57 linear regression Creatinine Clearance at entry 15 1.72E-05 rs35390951 37.57 linear regression GE Creatinine Clearance at entry 15 1.90E-05 rs35390951 37.57 linear regression AGE ₁ SEX Creatinine Clearance at entry 15 3.92E-04 rs35390951 37.57 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 15 3.94E-04 rs6493278 44.92 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 15 1.12E-06 rs6493278 44.92 linear regression Albumin/Creatinine ratio at entry 15 1.36E-06 rs6493278 44.92 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 15 3.10E-06 rs6493278 44.92 linear regression GE Albumin/Creatinine ratio at entry 15 3.54E-06 rs281243 44.92 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 15 7.66E-07 rs281243 44.92 linear regression Albumin/Creatinine ratio at entry 15 8.40E-07 rs281243 44.92 linear regression GE Albumin/Creatinine ratio at entry 15 2.48E-06 rs281243 44.92 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 15 2.53E-06 rs421853 44.93 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 15 1.61 E-06 rs421853 44.93 linear regression Albumin/Creatinine ratio at entry 15 1.85E-06 rs421853 44.93 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 15 5.34E-06 rs421853 44.93 linear regression GE Albumin/Creatinine ratio at entry 15 5.50E-06 rs1035704 44.94 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 15 2.27E-05

O rs1035704 44.94 linear regression Albumin/Creatinine ratio at entry 15 2.47E-05 rs1035704 44.94 linear regression GE Albumin/Creatinine ratio at entry 15 6.69E-05 rs1035704 44.94 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 15 6.84E-05 rs4775698 44.94 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 15 9.63E-05 rs4775698 44.94 linear regression Albumin/Creatinine ratio at entry 15 1.04E-04 rs4775698 44.94 linear regression GE Albumin/Creatinine ratio at entry 15 2.47E-04 rs4775698 44.94 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 15 2.56E-04 rs4774501 44.95 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 15 8.14E-05 rs4774501 44.95 linear regression Albumin/Creatinine ratio at entry 15 1.10E-04 rs4774501 44.95 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 15 2.08E-04 rs4774501 44.95 linear regression GE Albumin/Creatinine ratio at entry 15 2.59E-04 rs4775711 44.97 linear regression Albumin/Creatinine ratio at entry 15 2.13E-04 rs4775711 44.97 linear regression AGE ₁ SEX Albumin/Creatinine ratio at entry 15 2.26E-04 rs4775711 44.97 linear regression GE Albumin/Creatinine ratio at entry 15 3.24E-04 rs4775711 44.97 linear regression AGE ₁ SEX ₁ GE Albumin/Creatinine ratio at entry 15 3.87E-04 rs936308 45.42 linear regression AGE ₁ SEX Creatinine Clearance at entry 15 2.50E-04 rs936308 45.42 linear regression AGE ₁ SEX ₁ GE Creatinine Clearance at entry 15 3.71 E-04 rs624613 47.32 linear regression Creatinine Clearance at entry 15 2.68E-04

rs624613 47.32 linear regression GE Creatinine Clearance at entry 15 2.83E-04 rs10851710 57.08 linear regression Albumin/Creatinine ratio at entry 15 7.58E-05 rs10851710 57.08 linear regression AGE, SEX Albumin/Creatinine ratio at entry 15 8.04E-05 rs10851710 57.08 linear regression GE Albumin/Creatinine ratio at entry 15 9.92E-05 rs10851710 57.08 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 15 1.07E-04 rs399119 57.50 linear regression Albumin/Creatinine ratio at entry 15 8.52E-05 rs399119 57.50 linear regression AGE, SEX Albumin/Creatinine ratio at entry 15 1.02E-04 rs399119 57.50 linear regression GE Albumin/Creatinine ratio at entry 15 1.15E-04 rs399119 57.50 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 15 1.48E-04 rs2742323 71.43 linear regression AGE, SEX Creatinine Clearance at entry 15 1.74E-04 rs2742323 71.43 linear regression AGE, SEX, GE Creatinine Clearance at entry 15 2.28E-04 rs2730091 78.64 linear regression GE Albumin/Creatinine ratio at entry 15 1.75E-04 rs2730091 78.64 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 15 2.23E-04 rs2730091 78.64 linear regression Albumin/Creatinine ratio at entry 15 2.48E-04 rs2730091 78.64 linear regression AGE, SEX Albumin/Creatinine ratio at entry 15 3.13E-04 rs8025438 78.85 linear regression AGE, SEX Creatinine Clearance at entry 15 1.51E-04 rs8025438 78.85 linear regression AGE, SEX, GE Creatinine Clearance at entry 15 3.75E-04 o, rs4843007 78.85 linear regression AGE, SEX Creatinine Clearance at entry 15 4.88E-05

2 rs4843007 78.85 linear regression AGE, SEX, GE Creatinine Clearance at entry 15 1.56E-04 rs11635711 79.65 linear regression Albumin/Creatinine ratio at entry 15 3.31 E-04 rs11635711 79.65 linear regression AGE, SEX Albumin/Creatinine ratio at entry 15 3.33E-04 rs11633893 79.72 linear regression AGE, SEX Albumin/Creatinine ratio at entry 15 4.64E-04 rs11633893 79.72 linear regression Albumin/Creatinine ratio at entry 15 4.68E-04 rs11634707 79.73 linear regression AGE, SEX Albumin/Creatinine ratio at entry 15 4.56E-04 rs11634707 79.73 linear regression Albumin/Creatinine ratio at entry 15 4.74E-04 rs12906580 79.74 linear regression AGE, SEX Albumin/Creatinine ratio at entry 15 3.99E-04 rs12906580 79.74 linear regression Albumin/Creatinine ratio at entry 15 4.27E-04 rs7171048 81.28 linear regression GE Creatinine Clearance at entry 15 4.73E-04 rs7171048 81.28 linear regression Creatinine Clearance at entry 15 4.85E-04 rs10520631 81.28 linear regression Creatinine Clearance at entry 15 1.53E-04 rs10520631 81.28 linear regression GE Creatinine Clearance at entry 15 1.54E-04 rs11853578 95.76 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 15 4.60E-04 rs2881629 14.85 linear regression AGE, SEX Creatinine Clearance at entry 16 4.82E-04 rs2881629 14.85 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 4.97E-04 rs746312 23.18 linear regression Albumin/Creatinine ratio at entry 16 7.87E-05 rs746312 23.18 linear regression AGE, SEX Albumin/Creatinine ratio at entry 16 8.71 E-05

rs746312 23.18 linear regression GE Albumin/Creatinine ratio at entry 16 9.05E-05 rs746312 23.18 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 16 9.80E-05 rs6498678 31.85 linear regression AGE, SEX Albumin/Creatinine ratio at entry 16 2.13E-04 rs6498678 31.85 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 16 2.51 E-04 rs6498678 31.85 linear regression Albumin/Creatinine ratio at entry 16 2.69E-04 rs6498678 31.85 linear regression GE Albumin/Creatinine ratio at entry 16 3.43E-04 rs9929487 31.85 linear regression AGE, SEX Albumin/Creatinine ratio at entry 16 2.59E-04 rs9929487 31.85 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 16 3.09E-04 rs9929487 31.85 linear regression Albumin/Creatinine ratio at entry 16 3.27E-04 rs9929487 31.85 linear regression GE Albumin/Creatinine ratio at entry 16 4.19E-04 rs8057923 38.47 linear regression AGE, SEX Creatinine Clearance at entry 16 3.27E-04 rs8057923 38.47 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 4.18E-04 rs4508424 38.50 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 4.24E-04 rs4508424 38.50 linear regression AGE, SEX Creatinine Clearance at entry 16 4.74E-04 rs9933116 38.50 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 4.24E-04 rs9933116 38.50 linear regression AGE, SEX Creatinine Clearance at entry 16 4.74E-04 rs9925900 38.50 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 4.24E-04 rs9925900 38.50 linear regression AGE, SEX Creatinine Clearance at entry 16 4.74E-04

K> rs9935549 38.50 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 1.97E-04 rs9935549 38.50 linear regression AGE, SEX Creatinine Clearance at entry 16 2.09E-04 rs4438316 38.55 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 9.13E-05 rs4438316 38.55 linear regression AGE, SEX Creatinine Clearance at entry 16 1.19E-04 rs4459549 38.57 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 1.11 E-04 rs4459549 38.57 linear regression AGE, SEX Creatinine Clearance at entry 16 1.31 E-04 rs9930166 38.57 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 1.11 E-04 rs9930166 38.57 linear regression AGE, SEX Creatinine Clearance at entry 16 1.31 E-04 rs4420537 38.58 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 3.61 E-05 rs4420537 38.58 linear regression AGE, SEX Creatinine Clearance at entry 16 4.12E-05 rs12597579 38.58 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 1.93E-04 rs12597579 38.58 linear regression AGE, SEX Creatinine Clearance at entry 16 2.34E-04 rs4467088 38.60 linear regression AGE, SEX Creatinine Clearance at entry 16 3.50E-05 rs4467088 38.60 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 3.70E-05 rs16969790 38.61 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 9.74E-05 rs16969790 38.61 linear regression AGE, SEX Creatinine Clearance at entry 16 1.16E-04 rs1423713 42.36 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 3.24E-04 rs1423713 42.36 linear regression AGE, SEX Creatinine Clearance at entry 16 3.57E-04

rs250578 43.32 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 3.29E-04 rs7185200 77.15 linear regression GE Albumin/Creatinine ratio at entry 16 3.38E-04 rs7185200 77.15 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 16 3.86E-04 rs7185200 77.15 linear regression Albumin/Creatinine ratio at entry 16 4.38E-04 rs7185200 77.15 linear regression AGE, SEX Albumin/Creatinine ratio at entry 16 4.90E-04 rs4784909 77.43 linear regression AGE, SEX Albumin/Creatinine ratio at entry 16 2.01 E-04 rs4784909 77.43 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 16 2.39E-04 rs4784909 77.43 linear regression Albumin/Creatinine ratio at entry 16 2.41 E-04 rs4784909 77.43 linear regression GE Albumin/Creatinine ratio at entry 16 3.03E-04 rs825852 89.23 linear regression GE Creatinine Clearance at entry 16 1.23E-04 rs825852 89.23 linear regression Creatinine Clearance at entry 16 125E-04 rs825837 89.23 linear regression GE Creatinine Clearance at entry 16 1.53E-04 rs825837 89.23 linear regression Creatinine Clearance at entry 16 1.57E-04 rs825836 89.23 linear regression GE Creatinine Clearance at entry 16 1.83E-04 rs825836 89.23 linear regression Creatinine Clearance at entry 16 1.89E-04 rs825684 89.28 linear regression Albumin/Creatinine ratio at entry 16 4.93E-04 rs3111346 89.28 linear regression Albumin/Creatinine ratio at entry 16 3.16E-04 rs3111346 89.28 linear regression AGE, SEX Albumin/Creatinine ratio at entry 16 3.67E-04 rs41363750 91.51 linear regression Creatinine Clearance at entry 16 2.57E-04 rs41363750 91.51 linear regression GE Creatinine Clearance at entry 16 2.69E-04 rs1862819 110.70 linear regression GE Creatinine Clearance at entry 16 2.50E-05 rs1862819 110.70 linear regression Creatinine Clearance at entry 16 3.70E-05 rs1862819 110.70 linear regression AGE, SEX Creatinine Clearance at entry 16 1.03E-04 rs1862819 110.70 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 4.53E-04 rs6565006 110.73 linear regression GE Creatinine Clearance at entry 16 3.40E-04 rs6565006 110.73 linear regression Creatinine Clearance at entry 16 4.21 E-04 rs7205794 110.73 linear regression GE Creatinine Clearance at entry 16 4.27E-04 rs12596316 110.93 linear regression AGE, SEX Creatinine Clearance at entry 16 3.05E-04 rs12596316 110.93 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 4.11 E-04 rs8049648 112.94 linear regression GE Creatinine Clearance at entry 16 3.03E-04 rs8049648 112.94 linear regression Creatinine Clearance at entry 16 3.50E-04 rs11150545 113.00 linear regression GE Creatinine Clearance at entry 16 1.63E-04 rs11150545 113.00 linear regression Creatinine Clearance at entry 16 1.96E-04 rs8055016 115.07 linear regression AGE, SEX Creatinine Clearance at entry 16 9.23E-05 rs8055016 115.07 linear regression AGE, SEX, GE Creatinine Clearance at entry 16 1.94E-04 rs10781971 115.45 linear regression GE Creatinine Clearance at entry 16 1.46E-04

rs10781971 115.45 linear regression Creatinine Clearance at entry 16 1.74E-04 rs9940706 115.47 linear regression GE Creatinine Clearance at entry 16 1.95E-04 rs9940706 115.47 linear regression Creatinine Clearance at entry 16 2.29E-04 rs11641114 115.88 linear regression GE Creatinine Clearance at entry 16 9.50E-05 rs11641114 115.88 linear regression Creatinine Clearance at entry 16 1.20E-04 rs4843664 128.13 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 16 4.73E-04 rs4843664 128.13 linear regression GE Albumin/Creatinine ratio at entry 16 4.79E-04 rs4843664 128.13 linear regression AGE, SEX Albumin/Creatinine ratio at entry 16 4.93E-04 rs4790200 10.86 linear regression AGE, SEX Albumin/Creatinine ratio at entry 17 6.77E-05 rs4790200 10.86 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 17 8.20E-05 rs4790200 10.86 linear regression Albumin/Creatinine ratio at entry 17 8.74E-05 rs4790200 10.86 linear regression GE Albumin/Creatinine ratio at entry 17 1.16E-04 rs8072096 13.03 linear regression AGE, SEX Creatinine Clearance at entry 17 1.69E-04 rs8072096 13.03 linear regression AGE, SEX, GE Creatinine Clearance at entry 17 4.41 E-04 rs7215874 16.85 linear regression AGE, SEX, GE Creatinine Clearance at entry 17 3.52E-04 rs7215874 16.85 linear regression AGE, SEX Creatinine Clearance at entry 17 4.06E-04 rs1233861 29.53 linear regression GE Albumin/Creatinine ratio at entry 17 1.42E-04 a, rs1233861 29.53 linear regression Albumin/Creatinine ratio at entry 17 1.62E-04

2 rs1233861 29.53 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 17 2.34E-04 rs1233861 29.53 linear regression AGE, SEX Albumin/Creatinine ratio at entry 17 2.41 E-04 rs4792404 33.95 linear regression AGE, SEX Creatinine Clearance at entry 17 4.47E-04 rs11078205 33.97 linear regression AGE, SEX Creatinine Clearance at entry 17 1.36E-04 rs11078205 33.97 linear regression AGE, SEX, GE Creatinine Clearance at entry 17 2.26E-04 rs11078205 33.97 linear regression Creatinine Clearance at entry 17 2.58E-04 rs11078205 33.97 linear regression GE Creatinine Clearance at entry 17 2.76E-04 rs11078208 33.99 linear regression AGE, SEX Creatinine Clearance at entry 17 4.61 E-04 rs11652482 54.06 linear regression AGE, SEX Albumin/Creatinine ratio at entry 17 3.47E-05 rs11652482 54.06 linear regression Albumin/Creatinine ratio at entry 17 4.03E-05 rs11652482 54.06 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 17 8.41 E-05 rs11652482 54.06 linear regression GE Albumin/Creatinine ratio at entry 17 9.62E-05 rs1508959 74.10 linear regression AGE, SEX, GE Creatinine Clearance at entry 17 2.75E-04 rs1508959 74.10 linear regression AGE, SEX Creatinine Clearance at entry 17 3.02E-04 rs1508959 74.10 linear regression GE Creatinine Clearance at entry 17 3.43E-04 rs1508959 74.10 linear regression Creatinine Clearance at entry 17 3.52E-04 rs885633 84.06 linear regression Creatinine Clearance at entry 17 1.99E-04 rs885633 84.06 linear regression GE Creatinine Clearance at entry 17 2.01 E-04

rs1836649 1.40 linear regression Albumin/Creatinine ratio at entry 18 2.55E-04 rs1836649 1.40 linear regression AGE, SEX Albumin/Creatinine ratio at entry 18 2.57E-04 rs1836649 1.40 linear regression GE Albumin/Creatinine ratio at entry 18 2.98E-04 rs1836649 1.40 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 18 3.05E-04 rs1836648 1.40 linear regression AGE, SEX Albumin/Creatinine ratio at entry 18 2.56E-04 rs1836648 1.40 linear regression Albumin/Creatinine ratio at entry 18 2.56E-04 rs1836648 1.40 linear regression GE Albumin/Creatinine ratio at entry 18 3.09E-04 rs1836648 1.40 linear regression AGE, SEX ₁ GE Albumin/Creatinine ratio at entry 18 3.12E-04 rs1995715 1.44 linear regression AGE, SEX Albumin/Creatinine ratio at entry 18 2.13E-04 rs1995715 1.44 linear regression Albumin/Creatinine ratio at entry 18 2.22E-04 rs1995715 1.44 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 18 2.69E-04 rs1995715 1.44 linear regression GE Albumin/Creatinine ratio at entry 18 2.78E-04 rs 1226047 1.47 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 18 3.10E-04 rs1226047 1.47 linear regression GE Albumin/Creatinine ratio at entry 18 3.41E-04 rs501658 9.96 linear regression Creatinine Clearance at entry 18 7.42E-05 rs501658 9.96 linear regression GE Creatinine Clearance at entry 18 7.83E-05 rs12456026 10.00 linear regression GE Creatinine Clearance at entry 18 9.49E-05 rs12456026 10.00 linear regression Creatinine Clearance at entry 18 1.01 E-04 rs12963270 10.01 linear regression GE Creatinine Clearance at entry 18 2.14E-04 rs12963270 10.01 linear regression Creatinine Clearance at entry 18 2.18E-04 rs16956216 33.81 linear regression Albumin/Creatinine ratio at entry 18 1.18E-04 rs16956216 33.81 linear regression GE Albumin/Creatinine ratio at entry 18 1.55E-04 rs16956216 33.81 linear regression AGE, SEX Albumin/Creatinine ratio at entry 18 2.00E-04 rs16956216 33.81 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 18 2.78E-04 rs9953729 39.11 linear regression GE Albumin/Creatinine ratio at entry 18 4.41 E-04 rs9953729 39.11 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 18 4.82E-04 rs9953729 39.11 linear regression Albumin/Creatinine ratio at entry 18 4.92E-04 rs1616442 69.91 linear regression Creatinine Clearance at entry 18 4.76E-04 rs1616442 69.91 linear regression GE Creatinine Clearance at entry 18 4.86E-04 rs10503076 94.64 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 18 2.46E-04 rs10503076 94.64 linear regression GE Albumin/Creatinine ratio at entry 18 3.53E-04 rs7238248 94.64 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 18 3.82E-04 rs7244113 94.64 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 18 2.46E-04 rs7244113 94.64 linear regression GE Albumin/Creatinine ratio at entry 18 3.53E-04 rs6567316 94.64 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 18 2.63E-04 rs6567316 94.64 linear regression GE Albumin/Creatinine ratio at entry 18 3.87E-04

rs12966869 94.65 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 18 2.88E-04 rs12966869 94.65 linear regression GE Albumin/Creatinine ratio at entry 18 4.21 E-04 rs17070627 94.66 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 18 2.46E-04 rs17070627 94.66 linear regression GE Albumin/Creatinine ratio at entry 18 3.53E-04 rs1563734 94.66 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 18 2.46E-04 rs1563734 94.66 linear regression GE Albumin/Creatinine ratio at entry 18 3.53E-04 rs4799011 121.41 linear regression AGE, SEX Albumin/Creatinine ratio at entry 18 4.81 E-04 rs430544 124.34 linear regression AGE, SEX, GE Creatinine Clearance at entry 18 3.83E-04 rs8104451 40.26 linear regression Creatinine Clearance at entry 19 1.74E-04 rs8104451 40.26 linear regression GE Creatinine Clearance at entry 19 1.78E-04 rs7255326 40.27 linear regression Creatinine Clearance at entry 19 1.06E-04 rs7255326 40.27 linear regression GE Creatinine Clearance at entry 19 1.08E-04 rs7248013 40.27 linear regression Creatinine Clearance at entry 19 2.17E-04 rs7248013 40.27 linear regression GE Creatinine Clearance at entry 19 2.19E-04 rs17705657 60.30 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 19 2.64E-05 rs17705657 60.30 linear regression AGE, SEX Albumin/Creatinine ratio at entry 19 2.90E-05 rs17705657 60.30 linear regression GE Albumin/Creatinine ratio at entry 19 2.95E-05 rs17705657 60.30 linear regression Albumin/Creatinine ratio at entry 19 3.28E-05 rs4331429 82.69 linear regression Albumin/Creatinine ratio at entry 19 1.20E-05 rs4331429 82.69 linear regression AGE, SEX Albumin/Creatinine ratio at entry 19 1.29E-05 rs4331429 82.69 linear regression GE Albumin/Creatinine ratio at entry 19 2.28E-05 rs4331429 82.69 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 19 2.67E-05 rs8103089 99.89 linear regression AGE, SEX Albumin/Creatinine ratio at entry 19 1.60E-04 rs8103089 99.89 linear regression Albumin/Creatinine ratio at entry 19 1.96E-04 rs8103089 99.89 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 19 2.39E-04 rs8103089 99.89 linear regression GE Albumin/Creatinine ratio at entry 19 2.94E-04 rs8103254 103.03 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 19 4.47E-05 rs8103254 103.03 linear regression GE Albumin/Creatinine ratio at entry 19 5.45E-05 rs8103254 103.03 linear regression AGE, SEX Albumin/Creatinine ratio at entry 19 1.43E-04 rs8103254 103.03 linear regression Albumin/Creatinine ratio at entry 19 1.51 E-04 rs12609410 103.12 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 19 2.21 E-05 rs12609410 103.12 linear regression GE Albumin/Creatinine ratio at entry 19 3.10E-05 rs12609410 103.12 linear regression AGE, SEX Albumin/Creatinine ratio at entry 19 5.35E-05 rs12609410 103.12 linear regression Albumin/Creatinine ratio at entry 19 6.46E-05 rs257654 103.18 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 19 3.97E-05 rs257654 103.18 linear regression GE Albumin/Creatinine ratio at entry 19 5.35E-05

rs257654 103.18 linear regression AGE, SEX Albumin/Creatinine ratio at entry 19 8.64E-05 rs257654 103.18 linear regression Albumin/Creatinine ratio at entry 19 1.02E-04 rs8105738 103.30 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 19 1.77E-04 rs8105738 103.30 linear regression AGE, SEX Albumin/Creatinine ratio at entry 19 2.44E-04 rs8105738 103.30 linear regression GE Albumin/Creatinine ratio at entry 19 2.86E-04 rs810.5738 103.30 linear regression Albumin/Creatinine ratio at entry 19 3.45E-04 rs11668979 103.32 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 19 3.71 E-04 rs4816078 23.92 linear regression AGE, SEX Albumin/Creatinine ratio at entry 20 3.89E-04 rs4816078 23.92 linear regression Albumin/Creatinine ratio at entry 20 4.00E-04 rs926998 32.47 linear regression Creatinine Clearance at entry 20 4.26E-04 rs926998 32.47 linear regression GE Creatinine Clearance at entry 20 4.44E-04 rs11697280 32.47 linear regression Creatinine Clearance at entry 20 1.86E-04 rs11697280 32.47 linear regression GE Creatinine Clearance at entry 20 1.89E-04 rs11699491 32.47 linear regression Creatinine Clearance at entry 20 2.05E-04 rs11699491 32.47 linear regression GE Creatinine Clearance at entry 20 2.08E-04 rs6109342 32.47 linear regression Creatinine Clearance at entry 20 2.24E-04 rs6109342 32.47 linear regression GE Creatinine Clearance at entry 20 2.27E-04 rs6109343 32.47 linear regression Creatinine Clearance at entry 20 1.44E-04 rs6109343 32.47 linear regression GE Creatinine Clearance at entry 20 1.47E-04 rs11697678 32.48 linear regression Creatinine Clearance at entry 20 1.65E-04 rs11697678 32.48 linear regression GE Creatinine Clearance at entry 20 1.70E-04 rs4814087 32.49 linear regression Creatinine Clearance at entry 20 5.01 E-05 rs4814087 32.49 linear regression GE Creatinine Clearance at entry 20 5.41 E-05 rs6041265 32.49 linear regression Creatinine Clearance at entry 20 8.58E-05 rs6041265 32.49 linear regression GE Creatinine Clearance at entry 20 8.85E-05 rs997135 32.51 linear regression Creatinine Clearance at entry 20 2.00E-04 rs997135 32.51 linear regression GE Creatinine Clearance at entry 20 2.06E-04 rs16995428 34.93 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 2.08E-04 rs16995428 34.93 linear regression AGE, SEX Creatinine Clearance at entry 20 2.93E-04 rs2021935 39.47 linear regression AGE, SEX Creatinine Clearance at entry 20 1.94E-04 rs2021935 39.47 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 3.69E-04 rs16988954 55.56 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 2.33E-04 rs6103220 59.16 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 20 3.96E-04 rs11087002 64.35 linear regression Creatinine Clearance at entry 20 9.84E-05 rs11087002 64.35 linear regression GE Creatinine Clearance at entry 20 1.01 E-04 rs8115146 85.06 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 2.44E-04

rs8115146 85 06 linear regression AGE, SEX Creatinine Clearance at entry 20 3 10E-04 rs2092908 85 06 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 2 22E-04 rs2092908 85 06 linear regression AGE, SEX Creatinine Clearance at entry 20 2 93E-04 rs2224177 85 07 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 8 11 E-05 rs2224177 85 07 linear regression AGE, SEX Creatinine Clearance at entry 20 1 34E-04 rs2224177 85 07 linear regression GE Creatinine Clearance at entry 20 1 45E-04 rs2224177 85 07 linear regression Creatinine Clearance at entry 20 1 45E-04 rs2207899 85 07 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 1 06E-04 rs2207899 85 07 linear regression AGE, SEX Creatinine Clearance at entry 20 1 74E-04 rs2207899 85 07 linear regression Creatinine Clearance at entry 20 1 91 E-04 rs2207899 85 07 linear regression GE Creatinine Clearance at entry 20 1 92E-04 rs6098741 85 07 linear regression AGE, SEX ₁ GE Creatinine Clearance at entry 20 8 72E-05 rs6098741 85 07 linear regression AGE, SEX Creatinine Clearance at entry 20 1 45E-04 rs6098741 85 07 linear regression GE Creatinine Clearance at entry 20 1 55E-04 rs6098741 85 07 linear regression Creatinine Clearance at entry 20 1 56E-04 rs6069380 85 07 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 7 86E-05 rs6069380 85 07 linear regression AGE, SEX Creatinine Clearance at entry 20 1 32E-04 rs6069380 85 07 linear regression GE Creatinine Clearance at entry 20 1 42E-04 rs6069380 85 07 linear regression Creatinine Clearance at entry 20 1 44E-04 rs4811614 85 07 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 8 50E-05 rs4811614 85 07 linear regression AGE, SEX Creatinine Clearance at entry 20 1 37E-04 rs4811614 85 07 linear regression GE Creatinine Clearance at entry 20 1 40E-04 rs4811614 85 07 linear regression Creatinine Clearance at entry 20 1 41 E-04 rs6014453 85 08 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 8 45E-05 rs6014453 85 08 linear regression AGE, SEX Creatinine Clearance at entry 20 1 40E-04 rs6014453 85 08 linear regression GE Creatinine Clearance at entry 20 1 51 E-04 rs6014453 85 08 linear regression Creatinine Clearance at entry 20 1 52E-04 rs6014455 85 08 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 8 62E-05 rs6014455 85 08 linear regression AGE, SEX Creatinine Clearance at entry 20 1 42E-04 rs6014455 85 08 linear regression GE Creatinine Clearance at entry 20 1 51 E-04 rs6014455 85 08 linear regression Creatinine Clearance at entry 20 1 53E-04 rs6024333 85 08 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 1 46E-04 rs6024333 85 08 linear regression GE Creatinine Clearance at entry 20 1 61 E-04 rs6024333 85 08 linear regression Creatinine Clearance at entry 20 1 64E-04 rs6024333 85 08 linear regression AGE, SEX Creatinine Clearance at entry 20 2 43E-04 rs6024334 85 08 linear regression AGE, SEX, GE Creatinine Clearance at entry 20 1 02E-04

rs6024334 85.08 linear regression GE Creatinine Clearance at entry 20 1.51E-04 rs6024334 85.08 linear regression Creatinine Clearance at entry 20 1.56E-04 rs6024334 85.08 linear regression AGE, SEX Creatinine Clearance at entry 20 1.62E-04 rs876397 85.64 linear regression Albumin/Creatinine ratio at entry 20 4.78E-04 rs11086554 85.98 linear regression AGE, SEX Creatinine Clearance at entry 20 4.67E-04 rs2829583 19.92 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 2.20E-04 rs2829583 19.92 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 21 2.56E-04 rs2829583 19.92 linear regression Albumin/Creatinine ratio at entry 21 3.24E-04 rs2829583 19.92 linear regression GE Albumin/Creatinine ratio at entry 21 4.26E-04 rs2829585 19.92 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 3.73E-04 rs2829585 19.92 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 21 4.23E-04 rs1153257 26.15 linear regression Albumin/Creatinine ratio at entry 21 1.28E-04 rs1153257 26.15 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 1.52E-04 rs8129139 26.21 linear regression Albumin/Creatinine ratio at entry 21 4.60E-04 rs8129139 26.21 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 4.86E-04 rs9305380 26.22 linear regression Albumin/Creatinine ratio at entry 21 1.58E-04 rs9305380 26.22 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 1.77E-04 rs9980601 26.22 linear regression Albumin/Creatinine ratio at entry 21 3.61 E-04 rs9980601 26.22 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 3.85E-04 rs2831966 26.22 linear regression Albumin/Creatinine ratio at entry 21 4.98E-04 rs2091966 26.23 linear regression Albumin/Creatinine ratio at entry 21 4.72E-04 rs2091966 26.23 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 4.99E-04 rs8127707 26.23 linear regression Albumin/Creatinine ratio at entry 21 4.78E-04 rs2831984 26.24 linear regression Albumin/Creatinine ratio at entry 21 3.79E-04 rs2831984 26.24 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 4.00E-04 rs2831986 26.24 linear regression Albumin/Creatinine ratio at entry 21 4.65E-04 rs2831986 26.24 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 4.96E-04 rs7277331 26.25 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 3.29E-04 rs7277331 26.25 linear regression Albumin/Creatinine ratio at entry 21 3.33E-04 rs2832000 26.25 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 3.15E-04 rs2832000 26.25 linear regression Albumin/Creatinine ratio at entry 21 3.29E-04 rs741933 26.26 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 1.86E-04 rs741933 26.26 linear regression Albumin/Creatinine ratio at entry 21 1.88E-04 rs2832060 26.27 linear regression Albumin/Creatinine ratio at entry 21 7.14E-05 rs2832060 26.27 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 7.36E-05 rs2832060 26.27 linear regression GE Albumin/Creatinine ratio at entry 21 2.82E-04

rs2832060 26.27 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 21 3 45E-04 rs2832067 26.28 linear regression Albumin/Creatinine ratio at entry 21 3.50E-05 rs2832067 26.28 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 3 67E-05 rs2832067 26.28 linear regression GE Albumin/Creatinine ratio at entry 21 2 22E-04 rs2832067 26.28 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 21 2 81 E-04 rs7283314 26.28 linear regression Albumin/Creatinine ratio at entry 21 1 76E-05 rs7283314 26.28 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 1 87E-05 rs7283314 26.28 linear regression GE Albumin/Creatinine ratio at entry 21 1 21 E-04 rs7283314 26.28 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 21 1 , 57E-04 rs714036 26.28 linear regression Albumin/Creatinine ratio at entry 21 2 04E-05 rs714036 26.28 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 2.23E-05 rs714036 26.28 linear regression GE Albumin/Creatinine ratio at entry 21 1.27E-04 rs714036 26.28 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 21 1 , 65E-04 rs2832074 26.28 linear regression Albumin/Creatinine ratio at entry 21 10E-05 rs2832074 26.28 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 42E-05 rs2832074 26.28 linear regression GE Albumin/Creatinine ratio at entry 21 89E-04 rs2832074 26.28 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 21 51 E-04 rs2832075 26.28 linear regression Albumin/Creatinine ratio at entry 21 25E-05 o rs2832075 26.28 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 241 E-05 rs2832075 26.28 linear regression GE Albumin/Creatinine ratio at entry 21 143E-04 rs2832075 26.28 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 21 183E-04 rs2832078 26.28 linear regression Albumin/Creatinine ratio at entry 21 797E-05 rs2832078 26.28 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 841 E-05 rs2832078 26.28 linear regression GE Albumin/Creatinine ratio at entry 21 317E-04 rs2832078 26.28 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 21 393E-04 rs2832081 26.29 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 146E-05 rs2832081 26.29 linear regression Albumin/Creatinine ratio at entry 21 156E-05 rs2832081 26.29 linear regression GE Albumin/Creatinine ratio at entry 21 110E-04 rs2832081 26.29 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 21 128E-04 rs2832082 26.29 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 211 E-04 rs2832082 26.29 linear regression Albumin/Creatinine ratio at entry 21 220E-04 rs2832089 26.30 linear regression Albumin/Creatinine ratio at entry 21 749E-05 rs2832089 26.30 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 832E-05 rs2832089 26.30 linear regression GE Albumin/Creatinine ratio at entry 21 364E-04 rs2832089 26.30 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 21 481 E-04 rs1003671 26.33 linear regression Albumin/Creatinine ratio at entry 21 170E-04

rs1003671 26.33 linear regression AGE, SEX Albumin/Creatinine ratio at entry 21 2.06E-04 rs7283316 28.10 linear regression AGE, SEX, GE Creatinine Clearance at entry 21 3.28E-04 rs7283316 28.10 linear regression AGE, SEX Creatinine Clearance at entry 21 3.42E-04 rs2834269 31.09 linear regression Creatinine Clearance at entry 21 2.53E-04 rs2834269 31.09 linear regression AGE, SEX, GE Creatinine Clearance at entry 21 2.63E-04 rs2834269 31.09 linear regression GE Creatinine Clearance at entry 21 2.71 E-04 rs2834269 31.09 linear regression AGE, SEX Creatinine Clearance at entry 21 4.37E-04 rs7283567 44.58 linear regression Creatinine Clearance at entry 21 3.14E-04 rs7283567 44.58 linear regression GE Creatinine Clearance at entry 21 3.48E-04 rs9653818 49.94 linear regression AGE, SEX Creatinine Clearance at entry 21 8.83E-05 rs9653818 49.94 linear regression AGE, SEX, GE Creatinine Clearance at entry 21 2.54E-04 rs2839176 56.99 linear regression Creatinine Clearance at entry 21 1.72E-04 rs2839176 56.99 linear regression GE Creatinine Clearance at entry 21 1.84E-04 rs5997009 22.61 linear regression GE Creatinine Clearance at entry 22 1.96E-04 rs5997009 22.61 linear regression Creatinine Clearance at entry 22 2.07E-04 rs5997009 22.61 linear regression AGE, SEX Creatinine Clearance at entry 22 3.11 E-04 rs1894677 22.62 linear regression AGE, SEX Creatinine Clearance at entry 22 1.96E-04 o, rs1894677 22.62 linear regression GE Creatinine Clearance at entry 22 2.45E-04

^ rs1894677 22.62 linear regression Creatinine Clearance at entry 22 2.62E-04 rs1894677 22.62 linear regression AGE, SEX, GE Creatinine Clearance at entry 22 4.58E-04 rs17806543 38.30 linear regression Albumin/Creatinine ratio at entry 22 1.24E-04 rs17806543 38.30 linear regression AGE, SEX Albumin/Creatinine ratio at entry 22 1.43E-04 rs17806543 38.30 linear regression GE Albumin/Creatinine ratio at entry 22 2.12E-04 rs17806543 38.30 linear regression AGE, SEX, GE Albumin/Creatinine ratio at entry 22 2.55E-04 rs9622773 44.51 linear regression GE Creatinine Clearance at entry 22 1.77E-04 rs9622773 44.51 linear regression Creatinine Clearance at entry 22 1.93E-04 rs135439 48.93 linear regression AGE, SEX, GE Creatinine Clearance at entry 22 3.07E-04 rs135439 48.93 linear regression AGE, SEX Creatinine Clearance at entry 22 4.76E-04

Table 11 dbSNP RS ID Flank rs37965 ACAACATAGTAAGAGG [A/TJCATTGTTAACATTAAG rs9933116 GGCAGTGTAAGAGAGA[CZT]GGAAGATAGATAAAAG

γS17722044 GGCATCACAAGTCAGA[A/C]GGAATCTTGTGCAAAG rsl6831558 GGCCCTCTTαGTGCC[A/G]ATTTCACACACATTAA rsl6885649 GGCCTAGCTGCTTCTG[A/T]CAGAACCAACATTTTG rsl7100442 GGGAAGCTTGGATCAA[C/T]GAACTGGGCAGCCTTA rs3797716 GGGAGαGAATTCTCC[A/G]GCGACAGTTGTTGGGG rsl0933355 GGGTGTCTTGCAGTGA[A/G]AAAGAGAGACTGGACT rsl0987266 GGGTTATTTTCCCACC[CZT]GAAGTCACAGAGCATT rsl7568979 GGTAAATTAAGAAATA[C/G]CATAGCTGCAGATGTT rsl526591 GGTTTGTGTGTACTTA[G/T]CTAATTTTTAAAGAAG rslll91734 GGTTTTCCTTTCAGCC[C/T]GATACAGAGACCTGGG rsl0248657 GTAACCATGGACCCCA[A/G]TGCAATGTATTCTTGA rs6498678 GTACACATGAGAAGTT[A/C]AAAGTGCTCTGTGTTG rs483023 GTACTGATCGAGTAAA[A/G]TGTTGCTAATCTATTG rslO753291 GTAGGTTCTACCATCA[A/G]TCAGCTGGGCCTGAAT rsll24487 GTAGTTTGAGATGTTA[C/T]GCAGATTCTTGTGACC rs6906007 GTATAACAGAAATTTA[A/C]AGACATACACATTTAA rsll959439 GTCAC<^GTTTCAATA[CZT]AGGAATAAGCTGTGCT rsl455857 GTCAGGATGCATTTCA[A/G]AATCATGAGAAAGAAG rsl002170 GTCAGGGACTTAGCAC[C/T]GTGATCATGATTGTCA rs2207899 GTCTGCTGAGCTACTA[CZT]GGAGTCACAAATGACA rs4381737 GTGAACTTGGAATTGC[A/G]ATAGCACTAATACAAC rsll652482 GTGACAACCAAAAATA[C/G]GTCCAAAGATTGCCAT rs2237601 GTGAGTGACCGACTAG[A/G]CAGTTTGTTCCAGCTT rslll96566 GTGCATAACTCAGATA[C/G]ATGGCAGGATGAAAAA rsl6995428 GTGaAGAAAGTTATA[A/G]AATGGCACAAGGCATG rslO24125 GTGCTTTGCTCTGTTAIC/TIATTTTAAGTATCTTCT rsll69752 GTGGGGTAGATAGTTA[AZT]ATATGTTTGCCACCTT rsl7115571 GTGTAATTGTAAAATA[CZT]GGCACTAGAGAAATTG rsl7036102 GTGTGAACAAGTCATA[CZT]ATTTCCATCTGCAAAG rs9518171 GTGTGACTCTGAAAAA[AZG]TTGCTTGTGTCAATCT rsl689871 GTTAACCACCTAGAAG[AZC]CAAAATGTAAAAGGAA rsl7508334 GTTACAGCAAGAATTC[AZG]AACTACTAATCAAGAC rs6840808 GTTCTAAGCAATAAGA[AZT]GAAATCAAGAGAATGC rs41633 GTTGTCATTAACCTAG [AZG]AATTCATCCGAGTTAC rs6589403 GTTTCTACTGAAAACA[CZT]CGGCTGAAGAAGGCAG rsl7705657 GTTTCTGCTCTTTCTA[AZC]CGCGTGATAGCGGCGC rs4384747 TAAAACACAAGGGAAA[CZG]GATAGATGACAATACC rs343170 TAAAAGTGTGTAA<^[CZT]TCCCCCTACTCTCTCT rsl7714747 TAAACCTGCTTCATAG[AZG]AGAGCACATTAAGCTG rs9686988 TAAAGTATCCTGTGGA[CZT]CAAGGCTAAGGCTAAG rs2740485 TAAATGGTGCCTCTAA[AZC]ATAAAGGGAAATAAAA rsl571317 TAACATCAATTTCAAA[CZT]AAGGCTGTTCGCAATC rsl6831291 TAACCTCCTACTATTA[CZT]GATCCTGGAGTGCAAA rsll725538 TAACTTGCCAATGTAA[CZT]AAGTTAGTGTCAAAGC rs4404521 TAAGACCTCGTCTAAA[AZG]CATATAGTCTGTCCTG rsl2543318 TACAAATGGCTTTCAT[GZT]AGGAGATGTGTCCTTT

rsl966908 TACCATTTCAAATTCA[C/G]TATTCAAGCCATATAT rsl6831394 TAaAGCTGATGCCAG [C/GJAGGTGCCAAAGGTTGT rs2191644 TAGAAAAAAATAGGTAIA/GJGATTGGCAATCAGCAG rs7139910 TAGAAGAATTTTAAGAμ/ClGGCTTGTGATATAATT rs7532379 TAGAATGAGTACAAGC[A/T]CLI I I I I ACCCTTATC rsl6887282 TAGAGGATTACAAAGG[A/C]AGGAATGCTTTAAAAC rsl0959227 TAGAGTGAGATTCTGA[C/T]CATAGGACATGAAATG rsl637931 TAGAGTGAGGATTAAC[A/G]GAGAGCCAGGTGCCTG rsl233861 AACGTTGTGAGAAATC[A/G]CTTCAAACCTTTTCTC rs7747217 TAGCAATGGAAAGCTC[A/T]GAAAGTCTGAAGAGAT rs4387746 TAGCATAAATTGCCAC[A/G]CTACCAGCTAATTGAC rsllO13381 TAGCTTGAGTCCGAAC[A/G]CAGTCCTCTAGGAGAA rs9599174 TAGGAACATAGATGAA[C/T]GAGAGATTACTTTTCC rsl416079 TAGGTAGATTCTGGTA[AZG]ATAGCTGGGAACTATT rs4843664 TAGTATGTTAATTCAG[A/G]CGGCTATGCATGGTTG rsl2375830 TAGTCAACAAATCAAG[A/G]AAGGCCAGACACTGAG rsl854037 TAGTTGCAGGAAAATA[C/T]GGTCCAACCAGTTTCA rs39413 TATaATTTCTTGAAC[A/T]GTCTCTACGAGCCAGG rslO914789 TATGGGAGCTGATTGA[C/T]GGGTCATGTAAGATCC rsl2704196 TATTACATCCTAGGTA[C/T]AATGTAACAGGAGCAA rs2742323 TATTCCATAAGGGCAA[A/T]CTLI I 1 1 I I I CATACA rs4467088 TATTaCTTGGCaCA[C/G]TAACTAGCCTACTCCT rsll712997 TATTGATGAAAAAGAG[C/T]CCTTAATCTCCTTCTG rs6673199 GCCACACCCTTAGCCA[A/G]TCTTGGGCTGGATTTC rsl845255 TATTTATGAGTATCTA[C/G]TACATGACGAACAGTT rs3099280 TATTTCCACTAGACTA[A/G]GTTAAATATGTGAGAA rsl226047 TATTTCTAAATAATTC[A/T]AACTTTTGCTTTCTGC rsl0851710 TATTTTAGCAGAAGCC[A/C]AACAGAAGTGGCAGCA rsll838823 TCAAACAGACAAAAAA[C/T]GGTTTCATCAAATTGT rsl534735 TCAGAGTATGAAGGAAIA/GIGTTTGTATCTCAGAAG rs885633 TCAGTCATGTGCAAAT[C/T]ACCCTTCATACGTTCA rsl508959 GGAATGCAGCTGCGAA[AZT]ATGAAGGCGATAGATA rs6531246 TCCAGACAGTGTAGGA[AZG]ACCTGCTCACACCACA rs2021394 TCCATGGTTTACAATG[C/T]AGTGCAGTCAGAGAAC rs922284 TCCCAGTTCTCTCTTG[C/T]AAAGCCCCTATTTCAA rsl2218901 TCCCCAGCCTATAATA[AZG]CTTCTCTGTCTTTCCT rslO842321 TCCTTACAATGCCCTA[CZT]GCGGCCTAAATAATCT rs2730091 TCCTTTTAGAAACACA[C/T]GAGCAAATTGCAGTGA rsl7152806 TCGCGTTCTTAAGCAC[C/T]GAATTAGTTTTGGACA rs6595209 TCTAATTTTTGAGATAIC/TIAGGGACTTCTCTGGAG rsl7272567 TCTAGGTGCTTTTGTA[C/T]GTGTCTACTGATGGAT rsl0982727 TCTATGTATTAGATAC[GZT]GAATAAATCCATATTT rslO891623 TCTCAAAGCCTCATCC[A/G]CTGATTCCAGCAATGA rs9351813 TCTCCAGTTCCTATTA[C/T]ATTTCTGCCTAATTTT rs9351816 TCTGAACCACAAAGCA[A/C]AAAAATATTCTGAGTG rs501658 CCCTCTAGGCAAGCTC[A/T]CCCTTTCCCGCAGCTC rsl570092 TCTTCTCACGGTTGCA[C/T]TGAGGAAAAGTCTCa rs6103220 TCTTTGACTTACTCAT[C/T]ACCAACTCCAACTGTA rsl84255 TCTTTGCAATTTTGAAIC/TICATCTAATTCTACCTA rsl368003 TGAAAGGACAATTGAG[A/G]AGACCCAGAGAACGCA

rs4816078 TGAAATCCACACGGCA[A/T]CαCACATTTGGAAGC rs7331453 TGAACGATTATGACCA[A/G]CTCAGGGAGGCGAGAA rs420234 TGAGATATCCACACGA[A/G]AAAACTTTATAATGTG rsll793735 TGAGCTATATGAATGA[A/T]CTACAAGTCAGGAGAG rs617621 TGATCATAGCTGAAAA[C/T]AAAAAATCCAACAAAA rsl2595466 TGATGTCTTGGATCCA[A/G]CTGAAAATAAGTATGT rs479000 TGATGTTATACCAAAT[C/G]AGAATATCAAGTTACT rsl7725296 TGCAAGGCACATTαC[C/G]CAACTAGCTATGTAGG rs8103089 TGCACACAGAGATGAA[C/T]GGGCGAGGCTTCTCAC rsl891410 TGCACAGATAAGTACC[C/T]GAAAAGAGGTGTGGCC rsl7248895 TGCACAGTAGGACCAC[G/T]CAATGTTCACAGαCA rs6966228 TGCACTGAAGTGGTGC[C/G]ATGTGAAACCTCTAGG rs718734 TGCTATGGTATGCATC[A/T]CCTAGCTATGAAATGG rs809639 TGCTGAATAACTGATA[CZG]GTnTGAGAAAATnT rs4476578 TGCTTAAGTTGACAGA[C/T]GGAACACATTTTAAGG rsl7370786 TGGAGCCTTTTCCAAA[C/T]GTGGTAGGATATAGAA rs2704261 TGGAGTCTTCATAAAA[A/G]GAATTTGTCATGAGCG rsl0894280 TGGATCATGGAGCCAA[C/G]AGAGTGGACTAAGAAG rs930056 TGGCATCAAAGGTGGG[A/G]ACCTGTCTTTATTATC rs7248013 TGGTAAGGAACTTGGA[G/T]GCCATTCTAAACCTGA rsll963940 TGGTCAATTCAGGTTA[C/G]GGAGAAGAAACAAGTC rs2766551 TGGTCATCCATTTTCC[A/G]ATTCCCCATTCATTTG rsl3110738 TGGTTTAAAATCAGAA[AZG]GGCTACAATAAAAAAG rsl457659 TGG I I 1 1 I I GATCCAC[AZG]AAATATCTCATTCAAA rsl008981 TGTACAAAAACTTCAA[CZT]GGCCAGATAGATGGAT rsllO86554 TGTATCCTTGGGTGGA[AZG]AAATTTAGGTACTAGA rs3739455 TGTCCTCTAGAAGAAC[CZG]CTGAGCTTGCATGGAG rsl510699 TGTCTCCATAGGAACA[CZT]TGTATACCAGGTCTAG rs579392 TGTGACCTGGGACAAA[CZT]TATTCAATTGCAACTA rs8115146 TGTGaGGATCTTCAC[CZT]AAGCATTTGTTAAAa rs8055016 TGTGTGATTTGCATAA[CZT]AAGGCAGTACCTTAAA rs3198419 TGTGTTGGGGCACAGA[AZG]ATGAGTAGTACATAGT rs911214 TGTGTTGTTGGTATGC[AZG]GAACCCTTGCCCAAAG rsl816847 TGTTCACAaGTGTAT[CZT]AAGTC I I I I I GCaAA rs530991 TGTTCAaCAACATTC[AZG]ATGTGTGTTTATTGAG rs6932716 TGTTGGAAGTTCAGTC[AZG]ACATTTGTACAGTGGA rs2659508 TGTTTCCAATCTTATC[CZG]ATATTCCATCTTaCA rs7138576 TGTTTGAaGGaAGC[AZTJaGaCCAGAAAGCAC rs6557912 TTAACAATAaATCCA[CZT]CTTTTGTGAAAAGCAT rs4762802 TTAAGGCTTACaG AG [AZG] AGATCAaaGAaGT rs624613 TTACAGCAATGAAGCA[CZT]ATCAATGAAGCATATC rs2122208 TTAaGCATCATATAG[AZT]AGTTGTATTTTCAGTT rsl7070627 TTATaaCCAAAaG[CZT]ATTTCATTTTAGCAGT rs7769582 TTATTTAATGTGaCA[AZG]CTTTTAATGCAaAGT rs4843007 TTATTTGaTATTGAA[AZG]TAGTGAACCTTGTTTT rsl0045387 TTCAAATAATTGAAAA[CZT]GTCAGGAAATTCATAG rsl7056330 TTCAAATTTAATAATC[CZT]GAGAAAGCGaGTGTA rsl3148787 TTCATAGTGGACGaG[AZG]AGCCTTTAGAGTGGAG rsl6892595 TTCATGTTTAAATCAA[CZT]TGGGCACTTGAACAGG rs6585252 TTCATTAAaATGTCA[CZG]AGAGCAATTTGAGGa

rsl321627 TTCAI I 1 1 I I CCCTGA[C/G]ATGGTTTGACTTAGGT rs7807871 TTCCACAAATTGTTAA[A/T]CAAACTTTCTGTAGAA rs2224177 TTCCCATGAGGACTAA[C/T]AAACTTGTGTGGGGAA rs4444012 TTCCGTTTGTGGGTCA[A/G]TATCCCTTCCCCCAAG rs9856007 TTCTAATTCCACATGA[C/T]CTTGGCTGGTTAGAGA rs2659534 TTCTGATATTCTTCAA[A/C]ACAAACTGTTCAATAG rs736627 TTGAATTGTATCCCCCIC/TIGCCACCAAATTTATAT rs4790200 TTGACATATGCACAGA[G/T]GATCTCTTTTGATTCT rs2313862 TTGATAAGTCCCTGAC[A/C]CATAGATGGTGATCGG rs4775698 TTGCACAATGTAAACC[A/C]CAGGACTTATGGAGAA rsll247766 TTGCATACACCATCCAIA/GJTCATGTACACAGTAGT rsl882331 TTGCCCAAACTATCCA[CZT]GATCACAATGTTCTAT rs4710013 TTGCGGGTTTGTATGA[CZT]AGAGACAAGAAAGCAC rs4883520 TTGCTGAGTAAGCAAA[CZt]ATAGCA I I I I I CTTCA rsl7036142 TTGGACTGATGTACAA[CZT]TCTCATCTCTATAATG rsl0914782 TTGGAGAGGCAAGTTA[AZG]GGATATGTCTGTAaC rs905800 TTGGAGTCAAACTTAC[AZC]AAAGGGCTATTTATTT rsll634707 TTGGGAAAGTAGAATT[AZG]AAGGATGGACTTTGAC rsl7113090 TTGGGAAGAAATTCAC[AZG]ACCTTTTAGTCAATGT rsll69750 TTGGGACCAATAAGTC[AZG]ATCTCCTACTGAAGGT rsl464611 TTGTAATGGTTGTTTC[CZT]CATTCCGGTTGTTTAT rs2465836 TTGTGCATCACTAAGA[CZT]CGTTTTTGACTTTAAA rs8103254 TTGTGGGAGTACTTTC[CZT]AATGGTATCCGCTGAT rsl429675 TTTACAAATATACTTC[AZG]AAGTGAAAAGGTTGCA rs7646681 TTTATTACTTCCCACA[AZG]TATAATGGTTCCCTGA rsl3111562 TTTAITCTTTGCACAA[AZG]TTCAAATGTGATTTTT rs3111346 TTTCATTTAACATCTA[CZT]GAAACTTGAGCAAAAG rs6791890 TTTCTGTATTGTTTCA[AZG]aGTGTAACTGGGTTT rsl407684 I I I LI I GCTGTGGTTA[CZT]AAAATGGTTGTGTTTC rs2345070 TTTGCCTATTGCCTCC[AZG]AATTACATAGACCCTG rsl356704 TTTTACAGATAGAAGA[CZT]GTATACTAAGAAAGAT rs6931813 TTTTAGACATCACCTC[GZT]ACTTAGCACAGTCCAC rsll727037 TTTTAGCCAATGAGTG[AZG]AGCTGAGCAGCCACCA rslll95288 I I I I CI IATCTTTTCA[CZT]TATACCTGCGAATGTC rs4917579 TTTTTCACGAATGTAA[AZC]AAGTCATGTCTGTAAT rs2391782 TTTTTGTTTAGAAACC[AZG]GAATGTTGGAGATTAA rs996492 I 1 1 1 I 1 1 IATCAGTTA[CZT]ACAGCTCTTAGCACGA rs8105738 TTTACAAAGCATCTCA[CZG]CTGTCTCCTTGATCAC rslO22377 CTTGGTGCTGGGCAGT[AZG]ACGGTGGAAGTAGCCA rsl3423976 GCTAGGATTCCACTTA[CZT]AACCCAGAGGCACACT rsl0490107 GAATCCTTGTAGTTCA[CZG]TCCATCACAGTAGGAG rs6713 CCCTGGGTCAGCGCCA[AZG]AAGAAAACCTGGAGGG rsl946782 AAATGGGAGCTAGACA[C/T]TGAGAACACATAAACA rs2704785 GTCTCTGGACTGTGAA[CZT]ACTTTGAGAATAAGAA rsl370521 TTGCCAGGTGGACTGA[CZT]GCTGATTTCCAAGATT rs6014453 GCCAGGCAAACAACTC[GZT]CTAGCACAGTTGGCAA rs2091966 AAACAGACACTTCTTA[AZC]AATGAGGTATACAAGT rs741933 ATGAACATAAAGATGG[AZT]AACGATGCTGAGGACT rs2832060 CAGCAAATTGAAAAGA[CZT]GAAGATTGGAATGAAA rsl894677 TCCCTCGAAGGAAAAA[AZG]CCCATTGATGATTAGG

rsl7233898 AAGACCCTTTCTCTTA[C/T]GTTCTATGCTTCAAAT rs995082 TCTAGGTCTAGTCGGT[A/G]AACATCACCCATTAAC rslO511147 CTTATGAaGCAGAGA[GA]TCCCTTCGTATCGCAT rs3856765 GGATTGCCATGTGTGA[C/T]GCAACCCTTCCTAGAG rs4682326 GAGAATGAAATAAGGC[C/T]CACAGAGAACAGGAGC rsl401547 CAGGCAAGGTCTCCTC[C/T]AGCTGGCACTTGTACA rsl7496667 CAGATCTCTTTGATGA[C/T]ACTTAAATGTAGATAC rs4698574 TTCCTTTTACTAAGTA[C/T]AAATGTCCAGCATACA rsll57651 GGTGGTATTACTCAGA[C/G]GAATATGGTCAGACTC rsl2188594 AAACTTCCAGAACATA[CZT]GTAGAGCAGGTGCCTT rs347559 TTGaCAATCCCTGTC[C/T]CAGATTTTCATGAGCA rsl7146179 GAGAGAGAAATATGAA[AZG]GTTTGaGGTATAAAG rs982358 ACACCACATAACTAAA[C/T]GAATTGTTGTCTACCT rs4705945 AGAGGTTGTCACGTTA[C/T]AGTTGTATGCTTGCAT rs328043 ACTGTGGTAAATTATGtC/TlATTGTTGATGAGGTAA rsl504935 AATGGAAGTTTCTGTA[AZG]CATTCAATCTAATACA rsl0515781 TTATCTGTAAGATACA[AZG]GTAATCCATGCTCAAA rs6887080 AAATCTATGCACCTAA[CZT]TGACTTCACTTGCTCC rs9283873 GAGACTATAACTGCAA[CZT]GGTAAAAAGGCAGGAT rs541689 CATTTCACAGATGAGA[CZG]GACACTGAGAAGTTAG rs608873 TTATGTCCTGCATCCT[AZC]ACACTATAAAGCAAGA rs7740110 AGAAGATTTACCCCGA[AZG]ACTAGCCTGGAGACCT rs7747972 ATCTATATTGAATCCA[AZG]CATCTTAAGTTGCCTG rs539526 AAGGACATTTCAGTCA[AZG]TGACAGGCGACATATA rsl0872466 GAAGCAGGAGAGAGTA[CZT]CAGATAAGTAAAACAC rs4870150 CTTGTTGAAGGGCATA[CZT]GCGTTTGTTTTCCTGA rs887939 TGATTCATTGTGGTTA[CZT]ACTCAATCATACTCTA rs2106303 TGACTCAGGGAGAAAA[GZT]GAGATGGCTCTATCTT

γS12670939 CCATTATTGTATGTTA[CZT]AAACGAGGCCCAGGAA rs2350786 CATGGAGGCAAAaAC[AZG]GTAGCTGATTACCATT rs605257 GCAAAGAAAGTTTGAA[AZT]GCATAGGTACAGCAGG rsl6910240 GTCAaCCaGTCCAA[AZG]TCAAACaGGATTaG rs4313394 GaaOTAAGaaC[AZG]GAAGGCAGGGAACCCA rs4951625 TTGTTGAAAATGAGCA[CZT]CCTCGCTTTACCAAAG rs3842834 AAGCL I I I LI IACCTC[CZT]AAATGTTGaAATAGT rsl2067054 ATGTaGAGATTTCAC[CZT]AGACaAaGAATTCA rslO75329O CAGGGaGAaCAGAA[CZT]TGAGGTAGAGAAAAAG rs3845477 ATGGGCCCAAATTGTC[AZG]aAaCATTGTATTa rs746667 AGGCACTTGGCAAGTA[CZG]CATaCCTTTAATaT rsl0509120 TCaACAAAAAAATCA[CZT]GTGAGGCCAACCCCTT rs6416094 AaACAGATCaaAG [CZT]AGAATTAACAGCGAGT rs7926119 CAACAGACCGTGTTGA[AZG]TATTGCTTTCCATTGA rsl2220179 aAAGCAGACCTTGTC[AZG]aGAAGTTCACACAa rs4438316 AAACGTTaAATGTAG[CZG]AGTGaGATTAGAAAG rs4420537 GTTTTAaGAAGAAGA[CZT]GACGGATTGAATTGAC rs8049648 TAGTCAAAACCAATTC[AZG]CaAATGTaGOTCA rs2039709 CAAGATTGACCGTGGC[GZT]CTTTTCAGTTAATCCA rs997135 TACTTGTTAGCACaC[CZT]AATTA I I 1 1 1 I GAAAG rsl002548 TTCAAGTTGCTTGTTC[AZG]ATACGaGAGaACAG rs4959483 AATTCCCTTTGTTTAG[CZT]AGAAGCAaATCATCA

rs4870149 AAGAGAGAGTGTGAGA[CA]CAAGTCAAAAATGGAG rsll232346 TGATGGACGAATTAGC[Aλ]GCAAGTAAGGTAACTG rs7789785 CCACTTGαCGATCAC[A/C]GGAATGAAAGGCTGGC rsl545860 TTGTGGGTGGAGGAGAμ/GlGGAAGGACCCGAAGTT rs2829583 CATAATTAACAGAAAC[C/T]AGTATGGATCTTGTAT rs2829585 TATTCTATAAAGGTTA[C/T]GCAGGTAGAAACAAGA rs4583006 AACTTGATAAGCTAAT[C/G]ATCTGGGCTTACCCTT rsll53257 TTCAGTCCTTTTGTAA[C/T]AAAAATGCAGTCTCTC rs8129139 TAGCAACTATTCATTA[G/T]CAAGAAAGCATAAAAG rs9305380 GGAGCCTACCTGAGGG[A/C]AAGAGACTAGGAGGAG rs9980601 TAGAAACATGACCTCC[A/C]AGCTACTGTTTATATA rs2831966 CACCATCTGGGTGAGA[A/C] ACAAGTG ATTAGGGTG rs8127707 AGATCAGATGATTGTA[C/G]GCAGGAGGCTTTATTT rs2831984 GTACTGAGTGTACATA[AZG]AGAGATTTAGGGAAAA rs2831986 TAGTTTATTTGGGAGA[AZT]AACCTCAGAAAGCACA rs7283314 ATGGACCCGAATAACT[AZG]ACAATCACGTTGGAGG rs2832078 AAAACTGACATTCAAA[AZG]AATCTCCTGAGAAATA rs2832081 CCACCATAATAGTGAA[AZC]TAAAGCTTTGCTCACT rs2832082 GGGTTGAAATAAAATA[CZG]AAGTGCAGAAGAACTG rs2832089 GAGGGGATATGAGGGA[AZC]AGTTATGAAATGTTAT rsl003671 GAATATCCATCTCTGT[AZG]AAGAAACCGACTCAGC rs7283316 GAATAAATAAGCAGAA[AZG]GATGTACACTTACTTT rs2834269 CCCTCTGGAATGACAA[AZG]TGTACAAAACTTAGAA rs7283567 CAAGTGAGTTTTGATA[AZG]GGAL I I I I IACTATTG rs9653818 TTGATGTCATCTGTGG[AZC]ACTTTGCAGCTTGATC rs7559347 AAAAATTAACTTTTGA[AZG]CAAATGCAAGTGTTAA rs7518155 AAAACCAGACTCAAAC[GZT]GTTTCCAAGTAACAGA rs2881629 AAAACCATTGGATTCT[AZG]AAGGTAGAGGTCACCC rsl419090 AAAAGTAGGCTGACTA[CZT]AGTGACTTGCTTGATT rsll791772 AAAAGTTTCCTACATC[AZG]ATTLI I I I I I CAAAAA rsl7043569 AAACAGCTGTCCAAAT[GZT]AGAACCAGCAAAGTAA rs2214847 AAAGACTGAAGAAAAA[CZT]GAAAAGTGTCTGAGGG rs7255326 AAAGGAAATGGCATCA[AZG]TATGTCAAGGAGATAT rs2026692 AAAGGAACTATTCTTC[AZG]CTACACGAGCACTAAA rsl0865809 AAAGGGCATGAACTCG[AA]CCTTTTCCATGGCTGC rsl2042011 AAAGGTCTCTGGAACA[CA]CTGTTGAAGTGAACGA rsl0773546 AAATACTATAGTAGAC[AZG]CTGTAAACAAAAACGC rs4778549 AAATCACTAGTTGCAC[AZG]ATTπTCATTTGCTGG rsl550293 AAATGATTAACTGCAC[AZG]CTAAGAGAATACATTT rsll729556 AACAGCGTCTGGCAAA[CA]GTGTTTATTGTTATCC rs2013321 AACAGTGGATAAAGAA[GA]GGCTGCTGTATTCCTA rsl7791703 AACCAATTAGGATGAA[AZG]ACATGGTTAGAATAAT rsl6956216 AACCTCACCTCGTAAA[CA]AGGTGTTGACTTTTAA rslO188434 AACGTTTAAGATTCAC[CA]GTCTAAAACACTCATT rs876397 AACTGCAAAACTTTAA[AZG]CATAGTGATTCTAGGT rs3917851 AACTTAGTGTGGGTGC[AZG]AAATGCAATGCAAATT rsl2715148 AACTTATnTCAAATG[CA]AAGTCGAAATGTTTAA rs827282 AAGAGCTGGATGGCTA[CA]GCTACCCCAGAGGCTC rs825852 AAGATGGTAGACAGTA[CA]GGAGCTGAGAACCACA rs2073623 AAGGATGTTGAAGCAC[AZG]AAAGCATGAACTCGAA

rs9455160 AAGGTTGTTTTGGAAC[C/G]AGGTGAGAAAATACAC rsl7011370 AAGTCACATGACTGGA[A/G]CAGAAAAGAGCCTGTG rs667857 AATAATATGCCAAAAA[C/T]GTTTATGACTTTCTTA rsl7025028 AATAGCAGTTCTTAAA[GZT]GTTTGTATTATAGATC rsl7224336 GTTATACTCTAAGACT[A/G]AAACTCACTGAGGGTA rs9866755 AATαCAGAGTAGTGA[AZG]GTAAAAATAAAαθT rs7527158 AATGCCACTGCTGATC[A/G]AACAGTAAGTGAAACT rslll50545 AATGGAGGCAAAGGAA[CZT]GGCTCTTGCTTGAGGC rs6540484 AATTCTGGGGAATGGA[CZG]AGAACATTGATCTTAT rsl7539168 AATTGGCCACACGCTC[AZG]CATATGAGGTCATCAG rsl6877335 AATTGGTTTAGTCTAA[CZT]TGTGATGTATACACTG rs6425846 AATTTGCTCAGCCTTA[CZT]ACAATTTCTCCAATGT rs6761875 ACAATACCAGAGAGGA[CZT]AGCACTACACAGAGAA rsl7806543 ACACACACAAGAGACA[AZC]CACTCGGGCGGCCAGT rsllO48977 ACAGAGCAGGTTGTCA[AZG]TAAAGGCAGGCTGAAC rsl7751454 ACAGCCTTCTCTGATA[AZT]GTTCTTATGCATTGAC rsl7334370 ACAGCTTCCATTTTAC[CZT]CATCATCCCCATnTG rsl468196 ACAGGAGAAAGTATCA[AZG]TAGAACAGGACATGTT rs936308 ACCAACACCGATGAGA[CZG]AGCCCTGCCGTCTCCC rsll568046 ACCAATGGAAGTGTCC[AZG]GAGAAAAGCATCACCT rs696990 ACCACTCTCTGGAATC[AZG]CTATAAGTATGCTAAT rs257778 ACCACTCTGTGAGCTA[C/T]GTCCTATGGAACAAGA rsl7128987 ACCCCTCAACCCCTGC[AZC]AAACTCAAGAATTATA rs9843093 ACCTCTATTTAGTCAC[AZG]AATTTCTGCAATATCA rs7515512 ATTCATGTACAGCATA[CZT]GGTA I I I I I GCATGGG rsl0738180 ACTACTTTGGATTCCC[CZT]CTATTGTCTGTAATCA rs421853 ACTCAAAGAAGAGTGA[CZT]GAAAATTAAGTTCTGG rs4663165 ACTCCTGCCTTCTTAT[CZG]AAAGCTGCAGGCCTTG rs4147153 ACTCTAGTTCTTGACC[CZT]CTCCTATTGAAGTGCC rslll34856 AaGCTTAGACCTTAT[AZG]AAATAGGaGAGGGTC rs6651259 ACTTACCATGGGCCAG[AZG]aaATTaAAGCATG rs709934 ACTTAGTGTGGTCGCC[AZG]AAGATAAATCCACCCC rsl6844734 ACTTCCTTCAAAAGCA[AZG]GTTTAAGAGAATAAGG rsl506804 ACTTGaAGACATGTG[AZG]ATAGTATGGCATAGa rsl563734 AaTTaGaTTTGGA[CZT]GTATAAGCACAGCGTG rsl7056322 AGAAAATGTGCTTTTA[CZG]AATGTATGGACAAAAT rs6802276 AGAAAGGATTTGGAGA[GZT]aATTTATGGCAATCG rs8104451 AGAAGGGATGaCCAA[AZG]AAGTGTAGATTTTCa rsl571918 AGAATGaATTGCAAA[CZT]GTAAGTGACAAaCAG rs4459549 AGACCAACAAGAGGAA[AZG]GTaGTTGGAAGGTGT rs6069380 AGAaTAAGTTGTAAC[AZG]AAGCCAAGTTCTTGCC rs9935549 AGAGAGGTAGACAGAA[CZG]AGATCACAGAACAATC rsll087002 AGATATGCaGCAAGA[CZT]CAAATCCTTAAAAGGG rs825684 AGATGTACACACAAAA[CZT]GGATTTTCAGGATGAA rsl726392 TCATTGCTTAGaTAG[AZG]ATTTGAaGAAGAGAC rs6728947 AGCACaaATCAGTA[CZG]AACAGCGTTTaCCAC rs898828 AGCAC I I 1 1 I I I GTTA[GZT]CCATCACATGGTTAAG rsl2597579 AGCAGGGGGACaCAA[CZT]GTATATTAGTTACCAT rsl2456026 AGCATCCAaAACAGA[CZT]ATTaAAaCCACCGG rs4811614 AGCCATACACTTACCA[AZT]ACAACCAGATTTGATG

rsl926282 AGCCATCATTGAGGAA[C/G]AGTAATTTTTGCCAGC rs9953729 AGCCTGCGGGTAGACA[C/T]AGATTGGAACTGTACT rs7215874 AGCCTTGTCCGTAATA[C/T]GTGGGACCCTGGTCTG rsl3015251 AGCGTAAATACATGAA[C/T]GCTTCTGCTTACAAGT rsl961016 AGCTTCCACATAGCAA[A/G]ATAAATTACCAAGGCA rsl437121 AGGAAATCCAAGTCAC[C/T]AATATGTGGTATGTGG rs4331429 AGGCAAAAGAGATAGC[AZG]AGAGCGGTGGGGGGTT rs2592115 AGGαGGCGCCTCTTC[C/T]ACCACAAGGGAGGCTG rs2385127 AGGGAAαGGCCATTA[C/T]GACCAGTGGATAGAGT rs7530700 AGGGCTTGAACATGCA[A/G]TCCTATAGTGTGCCCA rs7531813 AGGTGTAGGAAACACC[A/G]AGCACTTCCAAGGTCA rs8021730 AGGTTCAGGGATTTTC[A/C]AGGGTCCTGGTTCCCA rs493642 AGTAGTAATCAATAAC[CZT]CCAGAATTCAGAGACT rs7795646 AGTATACTGCTATCCT[CZT]AAATTTTCAGGCCTCT rs764848 AGTATTTCCTTAATAG[A/G]CATATAGACAGCCCTA rs4931086 AGTCAAATTGAGCACA[A/G]AGGAAGGCACGCATCT rs527384 AGTαCCGATAAAATC[G/T]CAGAGAACTGTTTGGG rs9826565 AGTGATCAGTAATCTA[CZT]AGAAAACTTGAGGGGT rs7033145 AGTGTTCCATGAATAA[C/G]ACTGTTCGGGTCTAAG rs6431234 AGTTTCCTGTGAAAAT[C/G]AGACCTCGACCGTGCA rsl870703 ATAAAAGAAATGGAAA[AZG]GGATGTCAGGGTGTTC rsl2030775 ATAAAGTACAGCATTAtA/TJCTACAGACTGTGTGGA rsl361196 ATAACCTAGATAGATG[AZG]AAAACCATTATTTCTG rs2197879 CTTTACTACATAGTCA[AZT]CTGTGAATTC I I I CI I rs7123301 ATACATTTCACATTCA[AZG]TCTAATTCTGGTCAGC rs6431005 ATACCGCATCCAGAGA[AZG]GTCGCAGAGCCACAGC rslll95266 ATACCTATGGTTAAGA[CZT]GGTGCTTGGTAGAGGG rs3108049 ATAGAAAACTTTGACA[AZG]GTGATAGGTATCGTCT rsll699491 ATATAAATGGACATGA[GZT]AATAAGCCAACCTTTA rsl6838081 ATATAAGGATGAGTAA[AZC]AGTTATTCCTTGCCCT rs345677 ATATCAAATAGAAGAA[AZG]AACAAGTCACTCTCCA rs2942076 ATATTCACTGCTGTAC[CZT]CGCATGGACTTAGCAC rsll732298 ATATTTCATCCATTCA[AZT]TCTGTTCAGTCAGTTC rsl2138639 ATCAATTCTGGTAACC[CZT]GAGCAGCAGGAGAAAG rsl6892579 ATCCAGGTACAACCTC[AZG]ACTTAGGATGCTAGTG rs7752409 ATCCATCCATTTTAAC [AZT] ATCTACAG GTAATG AA rsl007007 ATCCCATG I I I I I I CC[CZT]GATAGAGCACTTTCAG rsl3008483 ATCTCTCTGTCTCAGC[AZG]CTACATACGAAGCTCC rs617215 ATCTTTGGAGATAGTA[AZG]AAGTTTCTGCTAAGGT rsl6894847 ATGAAAACAAACAAGA[CZT]GGTTACAGATTGCTAA rs6024333 ATGACACAGAGCCTCA[AZG]AATATGTAATTTTAAC rsll609178 ATGATCTGCTCTGAAA[CZT]AGCCTCACAAACTCTC rslll45647 ATGGAGGTAACTTCTA[CZT]GAGTATTCTCAAGGCC rsl7043640 ATGGGCAGAATTGGCA[CZG]AGTTAAAGAGAACCAC rsllO6O812 ATGGGTTTCTCCAAAG[CZG]CTGCTTTAGCTTCCTT rsl836586 ATGTAATGGATATATA[AZC]AGCCAGGTGCAAGCCA rs9829295 ATGTACTCAACCTCCT[AZT]AACCACCAAGTCTAGC rs9275134 ATGTTCTATTTCATCA[CZG]ACTCAGATAATAGGTA rs620095 ATTATATCCTGTACAT[GZT]ACTTCAAAACTGTGAT

γS9315454 ATTATTAAATGCCTCA[AZC]GACTTAACGGTCAGCC

rs2670132 ATTATTGCCTGGCATC[AZG]AAAATATGGGGGAAGG rs7976757 ATTCACAGTCCCAGAA[A/G]AGAGAGAACTGATTGG rs474519 ATTCACTGAACAAATA[C/T]CTACTGAGAATCTACC rs900060 ATTCTGTTTTAATATG[C/G]CAGGTTTTATGAAAAC rs225518 ATTTAATTTTCACAAC[A/G]GCACATGAGATACTGT rs7205794 A ^" nTATTTTCAGGCCC[A/G]GAACAAATTTGACTGG rsl995715 ATTTGAAAATGGGAGA[CZG]AAGTAGAAGCCAGTAG rsl0789252 ATTTGTTTACCTTTCC[A/G]CACATTGCCAGαGTA rsl0742654 AI I I I I I I AAGAAATA[CZT]GGTACAGATCAGTTGA rsl7167930 CAAAGATTCAGAAAAC[A/G]ATGCTTGAGAGAAATG rs2731699 CAACAACGTCAGAAAA[C/T]GCCTGCTAAAACCTAC rs7332804 AAGGGAATGCATAAAC[A/G]ACTTCTACCAATGTCA rs6440541 CAACTCTACTCCAAGA[A/C]AAGCAAATAGTTGTAT rs2496425 CAACTGTTCACCTACA[A/G]AGATTTCTGGGGCCTG rs8025438 G^AGAGAGAGTTTACA[CZT]AGTTTCTGTCGTAGCA rs250578 CAAGGAGAACAGGGTA[C/T]GCAGGAAAGGCAGGTG rs7715499 CAAGGGAAATCAGCAA[A/G]ATTGTATAGTCTCTCA rs2021935 CAAGTTTCCTGATTAA[A/G]ACAAAGCCTAGCCATT rs6433441 CAATCTCTGTTCTCAAIA/GIGGATTTATACTAAGGT rs473689 CACAAAGATGGGATTC[A/G]GAAATTGTCAAGATAT rs6790424 CACACCCCTAGTTTAA[C/G]TGGCAAAATCTGTCCT rs3779972 CACAGGCAGCTGTAGA[C/T]AGGACACTCTGCTTTC rsl6869370 CACATTTTTATTGACA[A/G]TGCCTAACATGCTGCC rs6949471 CACCAATAGCTGATCA[A/G]GTATGGCCACTCAGTC rsl912278 CACTGGAGAAAATCAA[A/C)GACTGTTCTCTAAGTG rs9940706 CAGACATGAGGCAAAT[G/T]ATGTCAATCCTATCAT rs4773558 CAGAGGACCTGCCTTT[A/G]AAAAGCCTATTTGTCT rsl2963270 CAGAGTAGCAGAAAAC[C/T]GTAATTCGTGAGAATA rs6478513 CAGAGTGTTAAAGTAA[C/G]TGGCCTAAGGTGTACA rsll934228 CAGATCCAAGTAAACC[A/G]CACTACATGCTCATGT rs6109343 CAGATCTATTCTGATA[C/T]CCTGATGAAAGCTACA rs6911435 CAGCAGGTCTTGTTAC[CZT]GATCTTGATGCCATTG rsl400685 CAGCGGCGCTAACAGC[AZG]ATGACCAATTAGAGCT rs6823069 CAGGAAAGGCTTACTG[AZC]AGTCAGGTGTCGCAAT rs4713784 CAGGTGTAGACAATCA[CZT]GTAACAACCAATCCTG rsl2906580 CAGTAAAGTTTAATCA[CZT]TAGGCAACTATTTATT rs7534285 CAGTAGGTACTTTACA[AZG]ATGCACTTAACAGATA rs7717186 CAGTCTTACCCCACCA[CZT]TGGTAAAATGAAATGA rsll754490 CATAAATACTTGTGCA[AZG]TACCCTCAGGACCTGT rsl7036230 CATACCAAATCAACCC[AZT]CAGTTTCACAGGAATA rsll697678 CATACCACCAACATTC[AZG]CATAAACTGCTTGGAA rs6887047 CATAGATAGCATTATC[AZG]GAATTGTGAACCCATT rs232892 CATAGGCCCAACTTCA[CZT]GGTGAAGGCCAAGACA rs751082 CATCAACTCACCAGGA[GZT]AGTGAGCACTAAGAAC rs4677766 CATCACCATGCATTCC[AZG]CACGAACCTGTGTTAA rsl6892587 CATCCCTCCTATCTGG[CA]AACAGGAATATTTGGG rsll633893 CATGAAACTTCGTαC[AZG]AATAATTTACCATTTT rsl447595 CATGCAGGAGCAAGTA[AZG]AAGAACATGGCAAGCA rslO238931 CATGGCTCTTaACAA[CZT]CTTCCCATTCCTTCCT rs3849423 CATGGTTCCCATGCTG[AZT]AGTTCAGATTGTCAAA

rsl7056139 CATTAATACCCAGGAA[A/G]TGACTCAAACCACAGT rs6547953 CATTAATTCAAAACAA[C/T]ACTTGACATCCTAGTC rs6449287 CATTGCAACACAGAAT[A/G]AGAAGTGACAAGACAG rs7761326 CATTTCCAAGAAGCAA[C/T]GCAAAGTAAGTTTTCC rsl7591814 CA I I I CI I GTCTCTAAfA/GJGTGAAAAATTGAAAAT rsl7036156 CATTTGGATGTCTCAA[C/T]GAαGACTCTTTATGC rs6596974 CCAAGCATTTTCTGGC[C/T]GATAAAAAGACTCTGT rsl0234484 CCAATGAGAAACAGTC[A/G]AGGTGATATGTGTGGC rs7787976 CCAATGCACTTGGAAA[C/T]TCACTCAATCTCAGCT rs257654 CCACATCTCCTAAATC[A/G]CGATCCTGGGCCAGTA rs2864246 CCAGATGGAAAαGAC[C/T]GAGAATAGTTTGGCAG rs8005269 GTGTGATTATCTGTGA[C/G]GTTAGTAGCATCTACA rsl2655096 CCAGGAGCTGAATCACIC/TIGGCGCTTTCATCTTGG rs7087063 CCCAGTCACTGTATGA[A/G]GTTAGCAAAACCTTGG rs349447 CCCATGGTGTTAGCCA[C/G]GGCTCAAGAATGAAGC rslll21778 CCCCAACCTGTGTGGA[C/T]GTTTACATAGATCAAT rs4774501 CCCCAGTGAGGAGGGA[C/T]GGTCATTTCTGTGATA rs760383 CCCCCAACATGAAAGC[A/G]ACGCCAGCAATTGGAG rs9925900 CCCCTCTGATGTTGCA[A/G]TATGCCTACAGAGGAA rsll668979 CCGCAAGACACCCGα[C/G]AACAGACACGTGTGCA rs4947833 CCGGATGαCATCCTA[C/T]ATGTTGACTTCTGACT rsll078208 CCTAGACATTGTCTCC[A/G]ATCTAACTCTGCCTTT rs4979805 CCTAGCCTATCTGTCC[A/G]GCCAGTCGAACCTCAT rsl7751499 CCTATTATTATTGGAC[C/T]ACTTGGCAAGTGCGAG rs869798 CCTCAGAAATGTGAAC[A/G]GTAGAGATGATTTTTC rs2095403 CCTCCCATTGTCTACA[C/T]TATCAAAAATAGCAGC rs2239544 CCTGAATGTCCTGTTC[C/G]ATTTTCATTGGTTTTA rsl206157 CCTTCTCTAGGATATA[C/T]GTCACCTATGGATCCA rsll206897 CCTTGACATTTGTACT[C/T]AAATCACTCTCTAGAA rs559663 CCTTGTTTCTTGATAA[C/G]AGAAGTTTAGTTCTGC rs6682062 CCTTTGGAGACCAGAA[C/G]AGCATTGACAGCCCCC rs257741 CCTTTGTAGATGTTGA[C/T]GAAAACAATCTGTTAC rs4652974 CGAGCTTGGTTTTGGA[C/T]GGTATTACGGACTGAA rs6790622 CGATCGGGTACTTATGIC/GIAAATTCTCAGGATATC rs2109273 CGCCTCTCGATGTTTA[C/T]GATTAAAGGAACAAAT rsl216192 CGGAGGCTGCCGTACC[A/G]CTCTAGCTACTTTTCT rs3917789 CGTGCAATAAATGCAA[A/C]CCTTATCTG ^" πTTCTA rs7161192 GACTTCTGGTTTGGTA[G/T]AGGCTGAAGCGCTCCT rsll853578 CTAAAAGAGTAAATTC[A/G]AAAGTTGGCTCTCTCC rs6883415 CTACACAGAGATTAGA[C/T]GCCAGCCTCAGCTACT rs2436140 CTACAGTCCAGCATAC[A/G]GAAGGCATTAAGAAAC rs236855 CTAGCGACTGTTAGTA[CZT]GGCAAAAATCTCTTAT rsll688740 CTAGGCTTGAATGAGA[A/G]AATAACGATACCTTTC rs2704259 CTAGGGTATTGTAGGA[A/G]GAAAATGCAGCAGCCA rsl3413437 CTAGTAAAACTAAAGCIA/GICTGTAACTAAATTCAT rs3917788 CTATAGAAGAACACCA[A/G]TGAATACCCATATGTG rsl3438289 CTATTCTATTTAACAC[A/G]GTAACACTGACCCTTC rslll22414 CTCAAAGAACTCACAG[A/G]CAAGTATTGAAGTCAG rsl6969790 CTCAAGTAAGCATCTC[C/T]AAAAGACAAATGAGGC rs6041265 CTCACTCTTTTGACTA[C/T]ATTCTGATGCCCTAAG

rs825836 CTCAGCACAGTTCTTA[C/T]GTTGGTTGAAGTGTCA rsl6931308 CTCTCTCATTTTαCA[A/G]GGAACTCTTCTGCATC rsll93167 CTαGCCTCGAATCAA[C/T]AGACTTAATATTTAAT rs347558 CTαGTCαGGAATAA[C/T]CαGCAATTAGGAAGT rs9368402 CTCTTTGTAGGαGAA[A/G]GGAAGTTTGAAGAAAA rsl886637 CTGAACTAAAGCAATA[CZG]CAGGAAGATCTGAGTT rs6936890 CTGACACTAGGGTGAC[CZG]GGAAATTGTATACGGG rs4667546 CTGAGGGATAGCACTA[AA]AACAGTACCAAAATGA rs4729505 CTGATATTGTAATCAA[A/G]GTGAGCCTAAGGCAAC rsll697280 CTGATGCAGGTTCTTA[C/T]ATGGTCTGAAGTTATT rs2726002 CTG(^AATTCAATGGG[CZG]AAAATTGTTGAAATAA rsl539174 CTGCTTCATAAAAACA[C/G]CTTAAATATATACTTG rsl620969 CTGGACATTGTTTATA[C/T]GAAGAACTGTπ ^" GGAC rs4560725 CTGGAGACTGCCTAAA[C/T]TGATTGAGTTCTGGGG rs430544 CTGGATGCCCTAATTCtG/T]ACATAAGCAGAGGTAT rs9310154 CTGGTCAAAAGCGAAA[A/T]CTTTTCTTGCCACTTA rs825837 CTGGTCTAAAGGAGCC[A/G]ACACTTAATGACTCCG rs2176696 CTGTAGCTCTTGAGGC[AZG]ATGAAACAGCGCTGAG rs9871437 CTGTGCCTGAAGTGCC[C/T]AACATTGTGCTCTGTA rsl0945231 CTGTGGCAπAAGTCA[A/G]AGTGACTCCTTCAAAG rs888576 CTTCAAAGTTTCTCTC[A/G]CACTGAACTATATTCT rs2310000 CTTCCTGTCTTCCTAC[AA]CTCTCTTGCACCAAAT rs778340 CTTGATGGTTTCCCAC[C/T]GCGCTAAGGGCTTGCC rsl0808772 CTTGCATTAATAATCA[C/G]AGGCGAGACTGCAGCA rs9508 CTTGCTTAGACATTAC[A/G]GGTTATGCTTTGAGAT rs26217 CTTGTTGACATTAGTA[C/T]GTGAGGACAAGTCCTG rs723432 CTTTACCTCTGTAACA[A/C]CTACCAGTTCTTCAGG rsl2062730 CTTTCTCCCTCACTTC[C/G]CATTTGAACTGCAGTC rs257737 CTTTCTCTGAATCTGA[A/G]GACAAAATGTGAAACC rs281243 CTTTGCCATCCGCAGA[C/T]AGCTTAAAGTTAACCA rs6425847 GAAAACTCTAGCAAAA[AZG]AGGATGAGTATAGGTA rs549879 GAAAAGAGCCCGTTTC[A/G]CAGGTGCAGGTGTTTG rs7029315 GAAAATATTTGAGGAT[AZG]AATGTCTAAATGCAAG rs5011048 GAAACAGGTATAGAGA[A/G]AAACATCTGAACAAAC rsl3095931 GAAATCTGCATTACAA[A/C]ACCCACTACCCTTGTT rsl7146098 GAACCCTGAAGAGAAA[A/C]CTAGTGTCTAATTCAA rsl7522707 GAACTCTAAGATGTGC[A/G]ATCAAGTAGGATCACC rsl6835075 GAACTGCAACAGATTC[AZG]ATAGGATGTTATTATA rsl318563 GAAGACTGGGCAACAAIA/GIGATTTGAGTACTAAGA rs7047415 GAAGCAACTTAGTTTC[C/T]CAATGAAAGCTGTAAC rs4792404 GAAGCCGTTGATACAA[C/T]CTTGATGTTATAACCT rs4315060 GAATAAAAGTATATCA[C/T]GGGAGTTACCTCTGTC rs677066 GAATAACAATCGCTAA[C/T]GATCCTCAAGTGCATG rs2378991 GAATATTGTTTAGCTA[C/T]GAAAAACACAAAAGTC rs8003168 GACAAATGCCTCTGACtA/GJAAAGGACTCTTGAACT rsll897612 GACACCTGACATAGTA[AZG]GCGATAAGTTCTAATA rs9930166 GACATTATAAATGCAG[CZG]CTCCTTCCATTTTCAG rslO894281 GACTAAGAAGCCACGA[AZG]AAAGGCATGAAGGAAA rsl519826 GACTGAAGAACTGTCA[CA]GGAATGGGAGAGACTG rs6790706 GACTTAAATATGTAAA[AZG]TTCTCCACCAGGACTG

rs35390951 GAGAAAGGGAATTCAG[AZC]ATCACACTCAGTTGAA rs4775711 CCTCCTGTTGTAGCTA[C/T]GGACTACCTTAAGGAG rs911213 GAGGACAAAGACTCTA[C/T]CTGTGGATTαAGCAT rsl836649 GAGGCATAGAATTAAA[CZT]AGTTGGTTAGGAGCAA rs2436139 GAGTATACCAαGGGC[A/G]AAAACACGCAATGTGG rsl2609410 GAGTATCTAGTCAACA[AZT]ATAAGGACCACAAAGT rs4921209 GAGTCATGGAGATAGT[AZG]AATACTTAGTGCAGTG rs3849511 GATAAGTCATCTAGCA[AZC]GTAAGGCTATCAATTA rs4444002 GATAATTATTTAACAG [A/G] AGCTACATATTGTCAG rslO841479 GATAGCTAGAAACCAA[GZT]AATTAATCAGAAAGTT rs636577 GATCCACAGAAAATCA[CZT]TGATGGCTGATGATTT rsl616442 GATCTGTTCCCTTCAA[CZG]TGGCAGTTTATATGTT rsl0980324 GATGACTTAGCTTAAA[CZT]GGATGTTGTAGTTATT rs740662 GATGCTGGTTGGCTGG[AZG]ATCTGAAACCACAACC rsl891487 GATGCTGTGAATTATC[CZT]CCTTGATGTCAGTGAA rslll21667 GATGGTATGTATGTCA[CZT]GGAGTCCCGCTGGGCA rs545865 GATGTTAATGCCAACA[CZG]AAGGTTGCAGTTTCCC rs4663163 GATTCAATCTGCTCTC[CZT]ACTGACGTGTTCTGTT rs2954365 GCAAGAAATGTCTCTC[CZG]CTTATCCAACATACCT rs304060 GCAAGTATTCTGACTG[CZT]CAGAAGGAAGTCAATC rs6421609 GCACACTAGATTTGTG[CZT]ATAGAAAACTTTCAGA rsl7080594 GCATGGCCTTGGGGTA[AZT]TACACTATGCCTAAAG rsl2403846 GCATGTTTCTAAAAAC[AZG]CTTCAGGAATCCAGAG rs7185200 GCCTCATATTGGAAGC[AZG]GATGCCATCTAAGAGT rsl0520631 TCAATmTCCATGAA[AZG]GAGTTCCTGGTGTAAT rs245659 GCTAATTATACTCGAA[AZC]CTGCTTGAACAATTTC rs9866627 GCTCATGGATCTTTTG[GZT]AGAATTGGATGAAAGT rsll834651 GCTGGAAAATCCTTAC[CZT]ATGACTGTAGTGTGTT rs6493278 GCTTTCAAGACAAACA[CZT]GAGAGAGAGAGCCCAA rs7953620 GGAGCGTACTGATTCG[AZG]ATGACCAAGAACACAC rsl7032901 GGAGCTCTTTTGTGCA[AZG]TGACTAAATGGGGGAA rsl2361863 GGAGTTGAAAGACCAA[CZT]GAATGACTTGGACAAG rsl035704 GAAAGCTTTATCTACC[GZT]GGAACATTAGCATTTC rs6109342 GGTATGCTTCCTATAC[AZG]CAGTCTTCCTTACCTT rs7550698 GGTGGAATTACATCCA[AZG]ATCTGCTATCCTGGTT rs9885206 GTAATTATAGTCACTA[CZT]ATTTGAAGTTGGTGCC rs7012070 GTCAAAAAGATGTCAC[CZT]GGGGAAAATAACTGCA rs852928 GTCACCTGAACAGCCA[CZT]GATTACAGGCGCATAC rs534685 GTTAAATGTCAATCCA[AZT]ATATπTGCTTACCTT rs905909 GTTAGGATCTGCATCA[CZT]GTGAGGCAATATTGTC rs5997009 TAGCTACCCAATAAAA[CZT]AGGCCATATTATGCCT rsl966909 TATAGCTCTTTGGTAA[CZT]AACAGAAAGGTCATTT rslO781971 TATCAGTCCAGGATCA[AZG]GAACCACACTACCTGG rs576550 TATCATAACAAAAAGA[AZC]CATGAGTTACCATTTT rsl0465598 TCATAGAGAATGGTGA[CZT]GATTATGAAAAGCAGC

γS1378500 TGCAAAAATGATAAAA[CZT]AGAGTTGGGATCAGTC rs693439 TGGAATATGGACTCAC[AZG]GAGTTTTTAACAACAT rs6990871 TGGCCTTTAAATAGTA[AZT]CAGAAGCAAACTTTAC rs6595849 TGTCAAATGTTGCAGA[GZT]TCACTTTTAAGATGTC rsl7013025 TGTTCTGTATTTCCAA[AZG]TAAGGCAAAAATTTAC

rsl0503076 CrCTTCrATCTCCTAA[CZG]TATTGACAGAGAACTT rsl2704200 TTCCCAGTCCATATAA[A/C]AGTTGTATGGACACTA rs7640488 TTGAAACTAATTATCA[C/T]CTGACGGTTCATTTCT rsl0812342 TTTGCTCCCGTGCCTG[C/G]AAATGTTACTCAAGGA rs924277 TACTGACCATAAATCA[G/T]CCAAGGTTTAGTGAAC rsl430220 CATCTTACAAGCTGCA[A/G]AGGGATGTGGCAGCAA rs714036 CTCTTTGGCCAATCCA[G/T]GAAATAAGGTGAGCAC rs2832074 ATCATCCCACACTCAA[CZT]TCAGAGGAAATCAGAC rs2832075 CAATTCAGAGGAAATC[A/C]GACCTTATTCTCCCTT rsl7031374 TATGTAAGGTGGGαA[A/G]AGAAATGTTTAAAAAG rs4683098 CACTTTCCTAATCTCA[A/G]GAACAAAGTGTAATCT rs6788511 TTGAGTCATTATCAGA[A/C]GTTTTAAAAGATCAAC rs4695256 CαGTAATTTTATCAC[C/T]GACGGCTAGCTTTCTA rs982605 ACCCTCCACTCTTTTC[A/T]ATCACTTGTCACATTT rsl6896055 CAGTTTAAAAGATGTG[C/T]ATTTGAACATTTCTAT rs2059943 GCCAAAAAACAGATAG[G/T]ATGAAATGTAGCTTTT rs3845476 ACAGGTGTTGAATGGA[C/T]GACGGAATGAATGACT rs7244113 AGCAGGTCAGTATCTG[A/T]CAAAATTCTCAAGGAA rs2832067 AGGATATACACAGAGA[A/G]CACAAACGTCCTATAA rs2839176 TAαGTTCCAACTACC[A/G]AGGACACTATTACTGA rs2717739 AAAGTGTCCCATTTAC[A/G]AAAGAACTG I I I I LI I rsl7178883 AAGCATTATCACATCA[C/T]TGAAAACTACAATAAA rslO8O8O62 AATTGTTTATGGAAGA[AZT]CAAATGGTCCAGAAGA rsl0492295 TCAAAGGAATTTTGCA[C/G]GTA ^" πTACATCTCTCT rs6538697 TCATGCπ ^" GCTTGTAC[C/T]GAAATGCTTGTATTAG rs7296106 ATACACTGCTTTCAAC[C/T]AAAACATTATTAGCAT rsl2411806 AGATTATTGAAGTAAC[CZT]GAGGAGATTCATGTGA rsl7674649 AGCCGCTGTGTGGCAC[G/T]CTGACAATGCCCTTTA rs8012459 AGGAGAGGGTTAGAAA[A/G]TATGGAATGAAAATAG rs974849 AGGAGTACCAACCTTA[C/T]GTTGCTAACACTGAGA rsl3279658 AGGTGGGTCAGATTCT[AZC]AATAACTTTGAGTACT rsl2463790 ATAGAGGAGGTGGGTA[AZG]ATAAGAGGCGATAGTG rs4904333 ATCTTTGTAGCTTTAA[CZT]GTAGAGTGGAGAAGAA rsll629078 ATGACCI I I LI I I I GA[AZG]GACATCTTTACGGTTG rs4334868 CAATAAAGGGAAGGAA[CZT]GCAATTTTGTGAGAAT rs7811306 CACACACATACACAAA[AZG]CAGGCAGCTTGCCAAA rsll253517 CACCTACCTCCCAGCC[AZG]CGTTCTCTTCCTTCAG rslO129357 CACTTCAACCAAAACA[GZT]CTATACTTATTTCTGT rsl836648 CACTTCCATCAGCCTA[AZG]ATCTTGAAAACTGAAG rs6024334 CAGGCAAGAGTTTAa[CZT]ACAGGCTAACGCGGAT rsl937076 CATAATAGGGGACATG[AZG]AAGCATGATACCTAAT rs9542982 CATGTGCTTAGGTCAA[AZG]GAACTAGTTTTAAAAA rsl493135 CCAATGAAAATTATTA[CZT]ACATTCGGAAGAGTAT rsl423713 CCCAGGAAGATGGAGA[GZT]AATTGGTACAAGTGGA rsl0465473 CGGGCAAAGGAAAAAC[AZG]CCCTAGTCATTCCATA rs4749929 CTAAACAGAAAAATTG[AZC]AATGTAGGAAAAATGC rs399119 CTGATCAACTCATG AG [GZT]CCTAAGATCAGTTCAG rs4814087 CTGTTGTTACACTACA[CZG]GTTAGCCAAAGCAAAG rs6872465 CTTTTATGTTTTATAA[CZT]GTGACACAAAGTAGTC rsl2043681 GAACCCAGGGAATTCA[CZT]GTGACTGGTTTAAGAT

rs2508492 GAGAGAGAAAGTGGAA[AZG]GAAACAAAATGAACAG rs4931081 GCCACAAGGACTGCAA[C/T]ATCTAGGTGAGTCTTA rs7238248 GGAGAAGAGCAGTTGTμ/GlAATGGGAGGTTGGCAA rsll641114 GGCATTAGGCAGCTGC[C/T]GCAGAAATACAGGTAA rsl35439 GGGCGGGTGAGGATGC[A/T]CTTCCLI I I I I CACGA rs6773962 GGTATATATTCAAAAG [A/G] AAACAATTGTTCTACC rs3794139 GGTCTGGTGTAAGGTC[C/T]AGAGCTTGCCATCAAG rsl2904911 GTGTTCATCATGTAAC[C/T]GCCATTTTTAAACCAA rsl2596316 GTTGCAGGCCCAATTAIC/TJACTTGAACAGAGGGTA rsl862819 CCAGGTTGACATTCAC[A/T]AATTGACAAATGTTAT rsl2024767 TAATCGCTTTTAAAGG[C/T]CCCAACTCAATACTGT rs7739957 TACTCCTCTCATTCAA[A/G]GATAAATTCTATGCCC rs4746746 TAGTAACATTGAATTG [A/G] AAAGG AAGTGAGGTGA rsl002169 TCCCTCCACAGCCACA[C/T]GTTGCTTTTAGCTTGC rsl2966869 TCTTCCACTTGGTCATIG/TIAAACAGCCACAGTTCT rsl628249 TGATGAGACCAAGTCA[CZT]GTGCATATGGTGGATT rs6567316 TTAG AATGCAAGTTAG [AZG) ACCAACATGATTAAAA rsl3149932 TTATACTGCATTAATG[GZT]AAGGACAAAAAGTGAA rs2283015 TTCTGTAGAACGCCTC[CZG]ACTTCCTCCCAGACGA rs2856688 TTCTTCAI I I LI I I GA[GZT]GCACAGAAGAACCCAT rs9393680 TTGGGTACAGTCCCAC[AZG]GATGGTTATTACTGTC rsl897164 AAAGGCATTCTCTACA[AZG]ATTTCCAATCAAGGAA rs6760957 TTTAAAACATGTCAAG[CZT]AGTAGAAAGTAGGGTG rs926998 AATTTTAGATAAACAC[CZT]GAACAATATTTCAACA rs6014455 CAGATTCAGCATCTAA[CZT]ATGTG I I I CI IAAGCC rs2832000 CATAGAACTATACAGC[AZC]ATTCAAGTAAATATTT rslO517818 CTGTATTTTAGATGTC[AZG]ACTTTAAGTAAGACTT rs37965 ACAACATAGTAAGAGG[AZT]CATTGTTAACATTAAG rs8057923 ACACTTAGTTAGAAAA[CZG]GTGAGCTTTCTAGTTT rs4508424 AATACTGAATTGTTTA[AZG]GAGAGGAAGAATTTTC rsl0509929 CTGTCTCCAGCAGTTA[CZG]GGTTCATTCTTAGGTT rs7277331 GCGTCCTAGAACAAAA[CZT]GGCAGGAGAGGCTGGG rsl6885654 AAAGGAGAGACTAAGA[CZT]GTAGTAAAGCAGTGGG rs7512140 AACGAATAATACTTGC[AZG]AACTCATCTAGATTTT rsl965193 AAAAAGAAAAAGAAAA[CZT]TGAGCTTATAGTACAG rsl240385 AAGGCGCTAGAGAGTA[CZT]GACTTGTGGCTGTTAG rs6533014 AATAAGCTCAGTGTTA[AZG]AAATGCTGAGTTTGAT rs8011308 AATGTGAAAATGAAAA[CZG]TCTCTTTGTCTGTGCT rsllO782O5 ACAAAGTGGGACAGGC[AZG]CTCAAGGCAGGAACAT

γS16922762 ACAACTTTATCTACCA[CZT]GTTTGCTCAAACTCAG rslO935316 ACACACCAAGCTCATC[CZG]ACCCCAGTATCCCACT rs2419044 ACATGCTCTTGAGAAA[CZT]AGAAGAATGATCTGCT rs2675967 ACCATCCTACAGATGA[CZG]GAGAAGGCACAGAGAG rs6563629 AGAAGGAGACATGCAG[CZG]AGTAGAGAGACAATAA rs4329752 AGACTG I I I I LI I I CC[CZT]ATGAaATTCATTCCA rsl7626940 AGCAGGTGCCTCCAAA[AZG]GTCTTACTAAGCCACA rs6586496 AGCATAGCCCAGAAAA[AZT]AATTTTTGCTCTACAA rs9821016 AGGAAATTGGATTAAT[AZG]AAACCTGGCACGTATT rs494965 AGGAAGTAGAGGAGAA[CZT]CATTCTGCCAGGCTAA rs470392 AGGGAAAGTAGAAGAC[AZG]GGGAAGTCGAAAGAGA

rsl7660836 AGGTACATCATCTGCT[C/T]AATGCACCACAGGTAC rs9929487 AGG I 1 1 I I I GGTCCTG[A/C]AAαGGACACAαATA rs3895563 TACCAAAACCTGCATC[C/T]GAAATAACTTCTAAGA rs8024417 ATTCAGTGAGTTAAAA[CZT]GGGAAGATATmTCA rs2092908 CAATAGGTAGTTTTTC[C/T]CTCGCTCTTCTGGTAG rs6098741 CAGAGATATGACTCTA[C/T]GαGAGATCGαAAGA rs7535475 CAGCCATCCTGGGAAA[A/C]GAATAATACTTGCGAA rs3741670 CAGaAAGACTCCTAA[CA]ATAAAAGAATTGCCAA rs6549869 CAGGTTTCCTGATAGT[A/G]AAACAGAAACCAGAGT rs8072096 CATAATGAAGACGCCA[A/G]AGGGCATAGCAGGGAA rsl2119983 CATTCaGAATGTTTG[A/C]AAATAGAAGAGGCTTC rs2659511 CCACTGCAGGAAACAG[A/G]CAAACCAGAGAGATTA rs3829270 CCCAGAGCAATGCCAC[A/G]ATAAAAATAGGAACCA rs590843 CCCATCCTAG CTTCCC [A/T]CATTCATCTCACACTG rs6596976 CCTCTTCTCTCTCTGG[C/T]AGAATCCTATATCGCA rsll927163 CCTGaGATCCAAACA[C/T]GGCTGTTGCTCTGCCA rsl6988954 CCTTGCTGCTCAGGAA[C/T]AATCATTGGAAaCCA rsl416078 CTAAGGCTTAGTTGGAfA/GlTAAGAATAAGAAGGAA rs3857545 CTCAGCATGAAAATCA[C/T]AGAAAACATCTGAATT rsll635711 CTCCATAACCCTCCCC[C/G]ACATTCTTAATACATA rs4784909 aCCCAGTCCAGTATG [C/T] ATCCCACCTAACTCAG rs746312 CTCTGTTGGCTGAGTA[C/T]AGTAGCTCATGCTTGT rsl0894277 CTGTCTACAGGCTGAA[A/C]TGTAAAACCTTTCCAA rslO16616O CTTCACGTGTCrCTAC[A/G]CTACTCTACGACATTT rs9622773 GAACAAAAACAGGCTA[A/C]AGAGAAGGATTTCCTA rs7844524 GATACTGGTTTTGCAC[A/G]CATAGGCTGAGGGAGT rs4799011 GCACACGTTCACGGAG[A/G]CCTCTCTTGGCAAGCT rs6565006 GCATGACTACGTCCCA[A/G]TACAACTTTATGTATG rs7171048 GCATGTGGCCCCAAAC[A/G]CTTCATTCTAGAGCAA rs2114913 GGAAAGCAACGAAAGC[A/G]ACGGCAGTTGGACTTC rsl416847 GGACAGAAGTCAGAAT[A/T]AAATGATTTCCTCAAG rs41415444 TTATTGTGTCACTGCA[A/G]AGAGTTCCATAATTAA rs41363750 AATCTTTCTGTCTCTC[A/G]AAATAATTCTCAAACA

Table 12

GENE_SYMBOL Gene Name

STK39 serine threonine kinase 39 (ste20/sps1 homolog, yeast)

MAK male germ cell-associated kinase

GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

FLJ45974 flj45974 protein

RNF14 ring finger protein 14

FSTL4 follistatin-like 4

FAM125B chromosome 9 open reading frame 28

SELP selectin p (granule membrane protein 140kda, antigen cd62)

GALNT7 udp-n-acetyl-alpha-d-galactosamineipolypeptide n-acetylgalactosaminyltransferase 7 (galnac-t7)

NRG3 neuregulin 3

UBLCP1 ubiquitin-like domain containing ctd phosphatase 1

C18orf58 chromosome 18 open reading frame 58

CDH13 cadherin 13, h-cadherin (heart)

CDKN2AIPNL similar to riken cdna a430101b06 gene

PCSK2 proprotein convertase subtilisin/kexin type 2

FGF14 fibroblast growth factor 14

SLIT3 slit homolog 3 (drosophila)

TXNDC8 thioredoxin domain containing 8

CAMTA1 calmodulin binding transcription activator 1

NID2 nidogen 2 (osteonidogen)

IGSF9 immunoglobulin superfamily, member 9

MCTP1 multiple c2 domains, transmembrane 1

LOC441108 hypothetical gene supported by ak128882

SMAD9 smad, mothers against dpp homolog 9 (drosophila)

KCNMA1 potassium large conductance calcium-activated channel, subfamily m, alpha member 1

SNX19 sorting nexin 19

NEBL nebulette

SLC01 B3 solute carrier organic anion transporter family, member 1b3

EEFSEC eukaryotic elongation factor, selenocysteine-trna-specific

ZHX2 zinc fingers and homeoboxes 2

PRDM6 pr domain containing 6

PEX5L peroxisomal biogenesis factor 5-like

FBXL7 f-box and leucine-rich repeat protein 7

CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta 3 subunit

ITSN1 intersectin 1 (sh3 domain protein)

SESN2 sestrin 2

DSCAM down syndrome cell adhesion molecule

PPP2R2A protein phosphatase 2 (formerly 2a), regulatory subunit b (pr 52), alpha isoform

MCM3AP mcm3 minichromosome maintenance deficient 3 (s. cerevisiae) associated protein

CTNNA2 catenin (cadherin-associated protein), alpha 2

ATF3 activating transcription factor 3

ATPIF1 atpase inhibitor precursor

GPR1 g protein-coupled receptor 1

SPAM1 sperm adhesion molecule 1 (ph-20 hyaluronidase, zona pellucida binding)

XYLT1 xylosyltransferase i

KLHL32 kiaa1900

MACROD2 chromosome 20 open reading frame 133

ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2

GRIK3 glutamate receptor, ionotropic, kainate 3

PSD3 pleckstrin and sec7 domain containing 3

MYH9 myosin, heavy polypeptide 9, non-muscle

HS6ST1 heparan sulfate 6-o-sulfotransferase 1

NPAS3 neuronal pas domain protein 3

TRRAP transformation/transcription domain-associated protein

EPHA4 eph receptor a4

RAPGEF1 rap guanine nucleotide exchange factor (gef) 1

LHFPL3 lipoma hmgic fusion partner-like 3

SDHB succinate dehydrogenase complex, subunit b, iron sulfur (ip)

RLBP1L1 hypothetical protein mgc34646

TGFBR2 transforming growth factor, beta receptor ii (70/80kda)

PCDH9 protocadherin 9

ACCN1 amiloride-sensitive cation channel 1 , neuronal (degenerin)

FAM135A kiaa1411

90 ACAA2 acetyl-coenzyme a acyltransferase 2 (mitochondrial 3-oxoacyl-coenzyme a thiolase)

ANK3 ankyrin 3, node of ranvier (ankyrin g)

GPHN gephyrin

GNAQ guanine nucleotide binding protein (g protein), q polypeptide

GLIS3 glis family zinc finger 3

C6orf57 chromosome 6 open reading frame 57

R0B01 roundabout, axon guidance receptor, homolog 1 (drosophila)

C10orf67 chromosome 10 open reading frame 67

PIK3C2A phosphoinositide-3-kinase, class 2, alpha polypeptide

LL22NC03-75B3.6 kiaa1644 protein

INADL inad-like (drosophila)

LTA4H leukotriene a4 hydrolase

CYP19A1 cytochrome p450, family 19, subfamily a, polypeptide 1

DNAJC8 dnaj (hsp40) homolog, subfamily c, member 8

CD40 cd40 antigen (tnf receptor superfamily member 5)

CORIN corin, serine peptidase

RHOH ras homolog gene family, member h

C15orf41 chromosome 15 open reading frame 41

TRIM29 tripartite motif-containing 29

CCDC113 hspcO65 protein

GRHL1 grainyhead-like 1 (drosophila)

ZPLD1 zona pellucida-like domain containing 1

C12orf35 hypothetical protein flj20696

ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6

SH3GL3 sh3-domain grb2-like 3

ZBTB16 zinc finger and btb domain containing 16

PLA2G4A phospholipase a2, group iva (cytosolic, calcium-dependent)

SYNE2 spectrin repeat containing, nuclear envelope 2

MAD1 L1 mad1 mitotic arrest deficient-like 1 (yeast)

PTBP2 polypyrimidine tract binding protein 2

C0G7 component of oligomeric golgi complex 7

PLCB1 phospholipase c, beta 1 (phosphoinositide-specific)

PPP3CA protein phosphatase 3 (formerly 2b), catalytic subunit, alpha isoform (calcineurin a alpha)

GSTCD hypothetical protein flj13273

DGKB diacylglycerol kinase, beta 90kda

FLJ34690 hypothetical protein flj34690

SDC2 syndecan 2 (heparan sulfate proteoglycan 1 , cell surface-associated, fibroglycan)

TA0K3 tao kinase 3

CCDC91 hypothetical protein

LIMS1 lim and senescent cell antigen-like domains 1

CHRM2 cholinergic receptor, muscarinic 2

INTS12 phd finger protein 22

AGBL1 hypothetical protein flj32310

GPR103 g protein-coupled receptor 103

VO CNTN1 contactin 1

UNC5C unc-5 homolog c (c. elegans)

NEURL neuralized-like (drosophila)

FCAMR fc receptor, iga, igm, high affinity

CNTN5 neural adhesion molecule

SCHIP1 schwannomin interacting protein 1

GPR114 g protein-coupled receptor 114

SGCD sarcoglycan, delta (35kda dystrophin-associated glycoprotein)

ADAM29 adam metallopeptidase domain 29

ITPR 1 inositol 1 ,4,5-triphosphate receptor, type 1

KCNQ3 potassium voltage-gated channel, kqt-like subfamily, member 3

JPH3 junctophilin 3

ARHGAP20 rho gtpase activating protein 20

KCND2 potassium voltage-gated channel, shal-related subfamily, member 2

PHLDB2 pleckstrin homology-like domain, family b, member 2

NAGK n-acetylglucosamine kinase

PRDM5 pr domain containing 5

WSCD1 kiaaO523 protein

ABCA1 atp-binding cassette, sub-family a (abd), member 1

GALNTL4 udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase-like 4

GGTA1 glycoprotein, alpha-galactosyltransferase 1

ZNF256 zinc finger protein 256

NCOA1 nuclear receptor coactivator 1

MY018B myosin xviiib

CAB39 calcium binding protein 39

SLC22A15 solute carrier family 22 (organic cation transporter), member 15

HIVEP3 human immunodeficiency virus type i enhancer binding protein 3

ZNF606 zinc finger protein 606

A2BP1 ataxin 2-binding protein 1

CR1 complement component (3b/4b) receptor 1 (knops blood group)

MAP9 aster-associated protein

CUGBP2 cug triplet repeat, rna binding protein 2

PLCH1 phospholipase c-like 3

SPNS2 hypothetical protein loci 24976

AKAP13 lymphoid blast crisis oncogene

SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

CSMD2 cub and sushi multiple domains 2

FREM2 frasi related extracellular matrix protein 2

C2orf82 chromosome 2 open reading frame 82

SNX29 sorting nexin 29

CDNA FU43836 fis, clone TESTI4005857. [SourceiUniprot/SPTREMBLjAccQβZUBS]

Novel protein (Fragment). [Source:Uniprot/SPTREMBL;Acc:Q5T481]

Novel protein (Fragment). [Source:Uniprot/SPTREMBL;Acc:Q5T481]

Novel protein (Fragment). [Source:Uniprot/SPTREMBL;Acc:Q5T481]

O NAGIl. [SourceiUniprot/SPTREMBLjAcciQδWZgS]

Novel protein (Fragment). [Source:Uniprot/SPTREMBL;Acc:Q5T481]

Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tral homolog)

La ribonucleoprotein domain family, member 5 [Source:RefSeq_peptide;Acc:NP_055970]

NAGIl. [SourceiUniprot/SPTREMBUAccQδWZθS]

NAGIl. [SourceiUniprot/SPTREMBLjAccQδWZgS]

La ribonucleoprotein domain family, member 5 [Source:RefSeq_peptide;Acc:NP_055970]

Novel protein (Fragment). [Source:Uniprot/SPTREMBL;Acc:Q5T481]

CDNA FU46161 fis, clone TESTI4002195. [Source:Uniprot/SPTREMBL;Acc:Q6ZRR4]

TABLE 13 rs2660228,rs2049923,rs2383618,rsl2592544,rs8092309,rsl749543 9,rs4724534,rs355334 ,rs2525835,rsl673087,rs9599611,rs7546559, rs9890795, rsl625889,rs2447334, rs2879553 ,rs382441,rs7555410,rs6838064,rs6084217,rs437168,rs314313,rs l767141,rs663486,rsl 1883698, rsl2528991,rs 9923450, rs728301,rs6080649, rsll44921, rsl6937066,rs730180,rs 2255957, rs7516560,rs4772258, rsl0210850,rs9535482, rs35998712, rslO929491, rsl704757 4,rsl2420010,rs4760403,rs7928379,rsl7034079,rs945272,rsll247 991,rsl856047,rs4707 442,rs6483778,rs9912445,rs9309664,rsl7447138,rsl2517092,rs75 72152,rslll60076,rsl 160267,rsll205641,rs2521746,rslll03479,rsl972468,rs6464078,r sl954724,rsll039856, rs6548843,rsl2418104,rsl3166360,rs6671359,rs6735179,rslll281 52,rsl000597,rsl7178 251, rs3121323,rs7519837, rsl2471047,rs2967391,rsl90937,rs9991140,rsl2311732,rsl07 51296, rs6664878, rsll563620,rsl0976595, rs4771015,rsl0781059, rs9358642, rs2549780, r s6565217,rs487642, rsl0072221,rs7615982,rsl456630, rsl7798680, rs 6697459, rs9509311, rs542036, rs3789813, rsl0782588,rsl7670092, rsl 6885649, rsll 694828, rs284174, rs655820 7,rs2119725,rs7754000,rs939776,rs2199695,rs6502509,rs3828692 ,rslll62957,rs731866 ,rs34053839,rs7627398,rs2343849,rsl411766,rsl345156,rsl70394 71,rslll93042,rsl713 6574, rs4759751, rs2427243, rs4878619, rsl7729010, rsl928161,rs4831364, rs6509802, rsll 883412,rs33660,rs2222411,rs2244262,rs276711,rsll889711,rs223 2950,rsl427033,rsl35 7127, rsl2695835,rs905950,rsl2927173,rsll604855, rs7754980, rs7730020,rsl7686603, rs 2119093, rs8067076, rsll857486, rsl2681074,rs2869826, rsll017045,rs6690837,rs6482595 ,rsl0733704,rsl415296, rs2513067,rs464910, rs7025042,rs6802085,rsl0846290, rs429686 6,rs2139793,rs6546314,rsl2446161,rs4866752,rs4897747,rs47814 95,rsl0178842,rsl088 3419,rs3012166,rslll44565,rs741463,rsll656859,rs882740,rs666 2675,rs2375537,rs779 2547,rs7835613,rsl7357586,rsll659760,rsl3268176,rs2158078,rs l3033653,rslll63795, rsl0741592,rs259218,rs676725,rs2078143,rsl7025763,rsl2612234 ,rs2318895,rsl021865 ,rsl3243874, rslO964590, rsl2080654,rs874617, rs2011559,rs2355988, rsl 6851413, rsl703 6090, rsll990111,rsl2694913, rs6012271, rsl347998, rsllO17613, rs9359928, rs7993583, rs 12823128, rs4710828, rsl0418203, rsl0173357,rs7769182, rs7570270,rs6022716, rsl712966 9,rs2241736,rs7309711,rs968860,rsl932594,rsl0411891,rsl09096 25,rs4927939,rs70915 33,rs7544170,rs2985862,rs461304,rs4948282,rsll959746,rs93493 37,rs7769514,rs69376 77, rs869901, rsll230463, rs638130,rs7202953,rs7172629, rs 9808967, rs7960700, rs739688 9,rsl2267934,rsl926836,rsl0948714,rsl7025231,rs2956052,rsl24 34170,rs2073233,rsl7 8252,rsl7833688,rs7598660,rs7326405,rs6984803,rs711413,rsl00 5425,rsl447344,rsl39 9572, rs3784819,rsl7141908, rs520765, rsl0995827,rsl243934,rsl2080191,rs8096331,rs7 172260, rs4951152, rs4238670,rs4930461, rs4916857, rs621208,rsl2406369, rsl6849708, rs 3810421, rslO879370, rsl318695, rs7044074, rs537910, rs 9644114, rs508520, rsll000930, rs 10893006, rs2292778,rsl0462377, rsl2190237,rsl7080859,rs7814548, rsl0492790, rs47151 51,rs3787348,rs5762040,rsl0861404,rsl2034237,rs28906,rsl0972 784,rs926336,rs66792 7,rsl6961803,rs4859918,rs6552145,rs2355777,rs8084280,rs92668 7,rsl6855226,rsl7099 462,rsl931646,rs6880595,rsl0205062,rs2029836,rs4942487,rs910 273,rs3760905,rs6592 575,rs2584940,rs613280,rs7459610,rs2251566,rs4543144,rs48725 24,rs2043745,rs35519 979,rs3852279,rsll646543,rsl342086,rs611382,rsl744879,rs2518 579,rs9541269,rsl090 3727, rsl2570292,rs4075152, rsl7828144, rs2337387,rs7986572, rsll 691240, rs4916183, rs 7316273, rsl777250,rs2793093, rs2590442, rs4690909, rs9894902, rsl 6840488, rsl839246, r s4916681,rsl0075212,rs9386165,rs294308,rs6088692,rs6444197,r sl0733118,rs8015211, rs7558038,rsl944634,rs5758951,rslll06205,rs2942905,rs566456, rs3814126,rs4405519, rs7044380,rs2072193,rs4673727,rsl0255150,rs6038985,rs6773879 ,rsl7140347,rs701368 6,rsl7542916,rs7012413,rs4679517,rs6831911,rsl7011711,rsll85 3646,rsl543362,rsl28 30193, rs972314,rsl6887818,rs641725, rsl7717431, rsll 618361 ,rslθl 91751, rs712411, rsl 729622, rsllO27951, rs4719141,rs2937497, rs4936451, rs933647,rsl0885315,rsl7092523,r s737904,rs533405,rsll744756,rsl046495,rs9463364,rs7521995,rs lll99575,rsl556046,r sll697977,rsl7164870, rsl7258702,rsl0171839,rs4638568, rs343916, rsl7162913, rs49211 61, rsl7692943, rsl 697504, rsll589870, rsl219861, rs6685584 , rs7916799, rs3790854, rs719 3756, rs2920059,rsl6920643, rs2022186,rs4696234, rs656251,rs6992337,rs3767183, rslO8 67105, rsl201378, rsl466156, rsl7042274,rs4862838, rs243908, rs2882387,rs7093280,rs51 1159,rs2972345,rsl3428604,rs9287990,rs4903238,rsl2152979,rsl lll4170,rsll827161,r

Table 13 -1-

s2582705,rs7230170,rs7739138,rs6936058,rsl2813386,rs40561 3, rs6728724 , rsl004704 , r s2555576,rs6135332,rsl7069783,rs2029805, rs3766572, rs9866334 , rsl2022319, rs6699132 ,rsl7021908,rs211170,rs701546,rsl7143056,rs9954495,rs7104390 ,rsl2136119,rsl89487 8,rs6030395,rsl2210179,rsll753875,rs7191753,rs9861525,rsl093 0656,rsl6968296,rs22 09803, rs7151036, rs4757268,rs4540179, rs4672096, rsl7576864,rs891346, rsl3424211,rs6 689141,rs4533822,rsl0141903,rsl0055470,rs4658446,rs923728,rs 4971169,rsl7066650,r s257954,rsl2211268,rsl3141990,rs4608849,rsl2644,rs622597,rs9 563876,rsl3343,rs947 8848,rsl7718330,rsl0771978,rsll070147,rsl7118171,rsll246796, rsl0172235,rs4369780 ,rs4804629,rsll069725,rs9399359,rs4889736,rsll87171,rsl48170 4,rs826645,rs4456126 ,rsl407881,rs6904566,rsl0808756,rsl7105805,rsl0735079,rslll7 2357,rs4236164,rs691 2819,rs7040314,rs2195866,rsl2453001,rs2287078,rsl0911456,rsl 0056306,rsll716997,r sl2020054,rs2240769,rs2260894,rsl0990901,rsl0747489,rsl05213 08,rsl359249,rs37321 79,rsl536792,rs7746731,rsl005659,rsl0148418,rs9463275,rs2774 052,rsl2364612,rs407 7841,rsl2585559,rs3756022,rsl0835150,rsl511730,rs980496,rsl2 3598,rs7581980,rsl01 22574, rs2038696,rsll687841,rs2580133,rs6776264, rs4683727, rs4851042,rsl7153496, rs 16835609, rsll675929,rsl2521615,rs2170055,rs523979,rsl0202310,rsl94521 3,rsl393492 ,rsl96646,rs2292095,rsl0076833, rs9577246,rsllO24625,rs4941832,rs2O36369,rslO5213 19, rs6440716, rsl870567,rs560630,rs4656007, rsl984413, rs2600960, rs834996, rs3885714 ,rsl3077722,rs877433,rs9346956, rs7161226, rsl6956086,rs2804118, rs3785474,rs459611 5,rs674503,rsl628627,rs4783935,rsl0457626,rs2278802,rsl01415 02,rs2337111,rsl2415 22,rsl7444755,rsl7754335,rs6602259,rs9568232,rsl6867690,rs48 87342,rsll47445,rs37 47556,rs2093619,rsllll6898,rs880306,rsl487200,rsl502060,rs67 7649,rs2758313,rs790 0353, rsl0278129,rsl2709691,rs2930961,rsl7637185, rsl7568725,rsl945733, rsll792480, rsl2421434, rs828655, rs567766, rsl50928,rs7670492, rsl0839217,rs791672, rs6442522, rs 1418843, rs2046720, rsl7215694,rs7999, rsl342017, rs640542, rs4305308,rs4684534, rs655 2690,rs2274913,rs9626521,rsl0775350,rsl7201937,rsll706332,rs 4284079,rs6826611,rs 10811932, rs6784235,rsll253584,rs7206166,rs9876921,rs287346, rs2302080,rsl2719304, rsll838578,rsl269287,rsll671,rs927440,rs902759,rs4902904,rsl l949255,rsl438928,rs 17156394, rs3937603, rsl2881815, rs652451, rsl0904739, rslllOl 110, rslO949860, rslO8395 85, rs6552073,rs2889620, rsll780074,rs2793699, rs9919721,rs4712005,rs9312600,rs4763 358,rs805554,rs3774326,rs7938491,rsl0955767,rsl0748248,rsl25 72508,rsl0848205,rs4 679742, rslO977684, rs4295245, rslO769595, rsl805571, rsl7416680, rs2512704 , rs9302544, rsl913096,rs6117234,rs4677403,rs724080,rs4147983,rsl7117041, rs7328301,rs4655979, rs758038,rsl96198,rsl460242,rs3936080,rs6587085,rs3007246,rs 6011674,rs241726,rs4 142197,rs2617795,rs563765,rs7189474,rs2026044,rsl7202174,rs5 08052,rs7778387,rsl3 72662,rsl0847818,rs9636067,rsll074140,rslll35368,rs375862,rs 6714749,rsll886886,r s4704952, rsll793823, rs4870162, rsl 6979505, rs578545, rsl7051043, rs717376, rs4390968, rs2817478, rs6550332,rsl956126,rs297774,rs6750393,rs2487783, rsl7632839, rsl2937550 ,rsl0090473, rs7080761, rs6722636, rs4383597, rslO747639, rslO885459, rslO760959, rs763 3240,rsl506096,rsl2320486,rsl888736,rs3013754,rs4759436,rs31 5084,rsl995826,rs806 9259, rs7947302, rsl3256305, rs2924683, rs7067921, rsl2599568, rslll88825, rs7806587, rs 423718 l,rs3732514,rsll790543, rs7670182, rsl991231,rs7012791,rs7791577, rslO821148, rs4509157,rs4398411,rsl731836,rs7012186,rs4316149,rsllll7489 ,rslll79212,rs286247 69, rs6682594,rsl7741363, rsl2625561, rsl 950193, rslO981762, rs3133395,rs7994174, rsl6 977185, rsl6970288,rs4783633, rs2276329, rs992157,rs3O26837,rsl7699561, rsl 665105, rs 553519,rsl057745,rs9405444,rs6438948,rs494246,rs662035,rsl02 2649,rs7567271,rs249 5965, rsl7280599,rsl0280313, rsl 6838019, rs938574 O, rs6003815, rs511114, rsl2003641, rs 7027328, rs2132190, rsl277621, rs924564,rs9937399,rs2179688, rsl 6902215, rs318699, rs2 353580, rs9969256,rs616402, rs882640, rs6668865, rsl2039454, rsl0927835,rsll711567, rs 4848928,rs3212247,rsl0973770,rs509544,rs7251402,rsl933734,rs 9314912,rsl0956754,r s552179,rsl2150111,rs2484086,rsl093994,rs2299257,rsl415913,r s6809319,rs6559754,r s422945,rs3765543,rs2131,rsl7111691,rsl519111,rs7046931,rsl2 422417,rsl0021686,rs 4954256, rsl7650453, rs6650896, rs223508,rs6587332,rs2197085, rs7229479, rsl 6948187, r s7968269,rs6573084,rs2156528,rsl2765150,rs6736755,rs273944,r sl7139118,rs2720433, rs7237496,rs725177,rs356942,rs7859898,rs8103217,rsll050625,r sl3072850,rsll241745 ,rsll562835,rs2648714,rsl0002082,rs200287,rs8056978,rs993699 9,rs4417546,rs683659 0,rs2630788,rs2756412,rsl438910,rsl0102886,rsl2624423,rs7800 902,rsl323949,rsl543

Table 13 -2-

605,rs4688868,rs2513998,rsl344669,rs344548,rsll982160,rs2404 646,rsl0770850,rs496 5006, rsl2301401, rsll51209,rsll076347, rsl7086577,rsl0778364,rs35805164,rsl0167057 ,rs980748, rs6496994, rsl7698247, rs9661040,rs7586356, rsll803285,rs7923045, rsl69234 31,rsl6920052,rsl856754,rs9289416,rs6676742,rs7187278,rsl396 485,rs7985641,rsl006 8304, rs4699261, rsl2652642, rs2344921, rs472691, rsl7363922, rs6742321, rsl500463, rs48 86707,rs7332401,rs930875,rs2362440,rsl59289,rs757647,rs58350 1,rsl0862080,rsl4456 28,rs2050583,rsl7043760,rsl2929500,rs8061003,rsl599281,rsl91 2879,rs2889113,rsl69 83574, rs745321, rs6461782, rs2365589, rs9558814,rsl836872,rs8062586, rsl7447375, rs34 3000,rs9396623,rs6802089,rs2962733,rs7853122,rs2703771,rsl82 8671,rs2170005,rs262 841,rs2279442,rsl6932800,rsl2214121,rs4432842,rsl7415114,rs3 917458,rsl751275,rs3 0191, rs3779110, rsl967604, rsl866924,rs6604658, rsl 6937817, rsl583259,rs8038172,rs76 39226,rs7136407,rs639154,rsll21330,rsll098342,rs2442357,rs40 5081,rs7746319,rs679 4128,rs4671408,rsl3386477,rsll212873,rs2176207,rsll241138,rs 629156,rsl0469892,rs 2510177,rs6882337,rs6764183,rs6750614,rsl334483,rsl0814476,r sl7718364,rsl353401, rs2035930,rsll214938, rs7963659, rsl559340,rs3764835, rs6715511, rs6708202,rs2794239 ,rs7313455,rsl495210, rs4984420, rs3802062,rs7983789, rs989396, rs7003175,rsl350959, rs6463855, rs2355100,rsl2578401, rsl7449834, rs4670455, rsl417299, rs2365140,rs479937 I,rsll48455, rsl691607,rs4804994, rs34831, rsl389247, rs4693920, rsl 6975239, rs204246, rs6889746,rsl2668555,rs9896078,rs9579838,rs6716235,rsl244148 5,rsl044670,rsl75418 46,rs7627477,rslll58548,rsl0456768,rsl563046,rs292084,rs9219 01,rsl0850194,rs9940 68,rs6456762,rs8082984,rsl7580584,rs8067682,rs2424887,rs9878 328,rs4738776,rsll22 2239,rs9871864,rslll9180,rs6703310,rs6825529,rsll53479,rs751 9725,rsl491198,rs221 4082,rsl250564,rsl075300,rsl0125273,rs2809158,rsl2934645,rsl 0969315,rs5757193,rs 16928902, rs2899395, rsl6910122,rs7673567, rs6439699, rs6806619,rsl0736862, rsl405733 ,rs6499976, rs4680945, rs828911, rs569953,rs9906933,rs594533, rs918352,rs2342309, rsl 7064788,rs9875109,rs4286667,rs4640343,rs3135378,rsll587014,r sl0801814,rs9513980, rs2613179,rsl0008326, rsl457325,rsl2149602, rs4678275, rs7805465, rsl366152,rs462865 7,rs3767991,rs7681841,rsl3274525,rsl2525741,rsl0033823,rs984 6123,rs969531,rs3845 608, rsl003158,rsll725538,rsl0815828, rs7300108,rsl2963692, rs6904911, rs6076466, rs3 755261, rs2023600,rs4536131,rs2590810,rs3096507,rs993137,rslll22554, rsl0032125,rs 12959259, rs3117330,rsl373035,rsl7170134,rs7909358,rsll233500,rsll2168 44,rs785991 5, rsl2139206,rs6769506, rs231873,rs3797299, rsl3185244,rs301164, rs4372543, rs698993 ,rsl931470,rsl0794986,rs2181987,rs584182,rs6802747,rsl027504 2,rs7747306,rsl30054 81,rsl0031148,rsl0212231 _; rs4537829,rsl7618991,rs4893858,rsl6942835,rs6556755,rs7 129125, rsl0132107,rs304578,rsl2943914, rsl0832696,rs2784273,rs9875977,rs3922878,r sl422069,rsl0882124,rs2249710,rs296266,rsl6879844,rs473989,r slll6836,rs3780416,r s529894,rsll563496,rs9561026,rslll89425,rs3114011,rs7228010, rs325781,rs7847479,r s6988980,rs7201500,rsll025443,rsll902772,rsl623472,rsl334726 8,rs9809388,rs932091 5,rsl400313,rsl0250887,rsl3098806,rsl910294,rs828240,rsl0444 722,rs4234447,rs4245 353,rsl3254646,rsl7789485,rsll772005,rs7106594,rs921808,rs78 05454,rsl0969802,rs6 860735, rs4882784, rs2701392,rs2009538,rsl7699790, rslO737170, rsl69046, rs2968882, rs 16982164, rs9373298, rs6968163, rs6041856, rslO881696, rsl3383563, rs6063523, rs792841, rsl7641195,rsl0211729,rsll924491,rs729128,rs333224,rs6038530 ,rs6807215,rsl898422 ,rsll062351,rs4264375,rs6959382,rsl580696,rs9857106,rsl09329 49,rs9359845,rsl7495 41,rs2540736,rsl353797,rs29355,rsl2403934,rs9507470,rs249838 ,rs679791,rs4858831, rsl7393543,rsl0733713,rsl998471,rs501580,rs7193497,rs8068853 ,rs3778248,rs4899813 ,rsl3411488,rsl0157512,rsll248319,rs7684466,rs2258367,rs3934 047,rsl6995404,rs647 4838,rsl034178,rs7151611,rs7530457,rs7036157,rs2306121,rsl02 11126,rsll016359,rs8 51981, rsl0141328, rs2593968, rs4125858, rs704738, rsl 1207488, rs4736403, rsll938858, rs 6140171, rs7983776, rs7593218,rs2483350, rs998095,rsl7114021,rsl77857,rs9820560,rs9 23489,rs3864148,rs6691586,rsl937410,rs9837015,rs6439600,rsl7 819647,rs4296360,rs8 55440,rs9616393, rs384283,rs 6030019, rs2109169,rslll96921,rsl6841682, rs4373488, rsl 7128788, rsl417823, rs4517161, rsll594365, rsl38866, rs897117,rs4791845, rs32136,rslO8 48977,rsl7500920,rsl2421053,rs6855151,rslll59460,rs4634676,r sl7001086,rs7507779, rsl31025,rs2389910, rsl2452034,rs4312485, rsl7404138, rs7649133, rs5743175, rs8136206 ,rs6753178,rs2320952,rs4737054,rs2110745,rs889268,rsl3358120 ,rs6683452,rs4451059 ,rs896683,rsl491392,rs9318335,rsll622302,rs2733379,rsl203465 7,rs6670103,rsl21945

Table 13 -3-

13, rs4784805, rs7567073,rs4695096, rs4781563, rs7820652,rs8020273,rs6672200,rsl7177 32,rsl7198764,rs2661015,rs2964112,rsl0012993,rs314023,rs7559 189,rs7334921,rsl210 7950, rs966770,rs2365206,rsl7067368,rsl 6943635, rsl564026, rsl507742, rsl0099820, rsl 2486784,rs35069045,rsl5563,rsl0463976,rs4667454,rs7162276,rs 7845087,rsl0119616,r sl6918111,rsl7568882,rs7851076,rsl7084933,rsll079111,rslll63 466,rs209753,rs30108 86,rs3814309,rs8007677,rs6962291,rsl7119329,rsl668331,rs6820 517,rs2783399,rs7582 141,rs2050144,rs3859250,rsl7703211,rsl2502934,rs6602587,rsl8 83784,rsl0521230,rs7 828090, rs3795479, rsl2774009, rsll922785, rslll70402, rs7439975, rs700021, rs2722380, r s2151563,rsl0775377,rs6995404, rsl3333329,rs6469697, rs7738571,rs9304004, rs4901119 ,rs9599174,rs6793644,rsl0924556,rslll09877,rs2579889,rs22852 91,rs4711518,rsl7677 404,rs2406903,rs7513563,rs4674711,rsl37461,rs7924341,rsll692 330,rs6758088,rs2176 312, rsl7078709,rsl2288455, rsl7677777, rsl 6942962, rsl881228,rs7172257, rsl711238, rs 12430547, rs2546963, rs2915972,rsl800609,rs2953518,rs33528,rsll242127,rs427171, rsl 2831514,rsl994346,rs6492565,rs2905479,rs3741370,rs2852949,rs 3995549,rs6729732,rs 2623770, rs2278844, rsl798710, rs452577, rslll22577,rs4963674, rsl2786429, rs688994 l,r si 982014, rsl7609252,rs4950076, rs26090,rs425083,rsl2452190, rs924971, rs4743837, rs9 822322, rsl6931331,rsl0065859,rs6954608, rs9304655, rs7844632, rsl0758076, rs2493586, rsl453026,rs9660122,rs4783619,rsl0940601,rs9546007,rs6035902 ,rsl7169689,rs770807 9,rs810551,rs2066735,rsl480358,rs4964109,rsl0239457,rsl75631 53,rsl286233,rsl0260 320, rsl7617013, rsl7663138, rs6956369,rs7992287, rs7371826,rsl999898,rs920113,rs210 7831, rs2299971, rs7972058, rslO512426, rsll202557, rsl3061546, rsl519380, rs2037180, rs 11147823,rs6576946,rsl0911481,rsl2021074,rsl0096045,rs711850 8,rs7520184,rsll6670 9,rs909975,rs2731670,rsl0460436,rsl511830,rs7334540,rsl69624 46,rsll45750,rs44104 72,rs7572953,rsl7108107,rsl7111609,rs6746088,rs2710630,rs704 6713,rs2027586,rs764 4775, rs9810385, rs6938814, rsl7811120, rs6115273, rsllO98375, rs7707099, rslllδδ 950, rs 1660208, rs7339413, rs4712786, rs2051710, rsl7039367,rs7187579, rs4506209,rs2398993, r sl7008507,rs4293434,rsl779444,rs6503167,rs9633971,rsl0740353 ,rs7147367,rs215349, rs7661397, rs7076375, rs2772559,rsl538291,rsl0841662, rs3741629, rsll853501,rs689520 l,rs4735098,rs7090051,rs7017481, rs7522621,rsl0191269,rs9946888, rs7675613, rsl2636 86,rsl0871590,rsl7136948,rs822611,rs7931502,rs2136936,rs9957 562,rs2971027,rsl775 5356,rs7514267,rs7326226,rsl0887564,rs543560,rs2753433,rs399 5498,rsl7178928,rs97 89497,rsl2152861,rs4413512,rs2691148,rsl7631843,rs9929676,rs l7106502,rs2164422,r sl7191316, rs7163636,rs4417224, rs6166,rs6035841,rsll769709, rsl7248681,rsl2933929, rsl7501618,rs4143025, rs2253084,rs4879981, rsl6849172, rsl3124292,rs6829635,rs71736 87,rsl6836411,rsl0928206,rsl6971624,rs6768637,rs847821,rsl68 78962,rs5015536,rsl6 850188, rsl962172,rs7543704, rs4389020, rsl448394, rsl7065069,rsl0789843, rs4973305, r s6946690,rsl7085577,rs546048,rs6942538,rs8177832,rs9364756,r s6856498,rs4781935,r s9330251,rs755763,rsl7205084,rs383884,rsl016679,rs290663,rsl l213089,rs386168,rs9 906356, rs8109301,rsl2300114,rsll043347,rsl003406,rsl206149, rs6073055,rs7014110, r S10989793, rsl0800619,rs9805813, rsl0785859,rsl46504 I,rs6934260, rslO134600, rs46627 30,rs946236,rs7302830,rsl0222715,rsl2960966,rs2053828,rs2791 3,rsl7116469,rsl0478 021, rs2182013,rslll35023,rsl7778162,rs719703, rs7534322, rsl7120330, rsl2024617, rs6 41430, rs9766017, rs9542745, rs3020270,rs2713827, rs4541731, rsl7063376,rsl888839,rs4 787658,rsl0102469,rsl7362902,rsl0174918,rsl2923268,rs7334521 ,rsl6899578,rs982126 8,rsl7734981,rsl903027,rsll584314,rs4808,rs4321346,rs7355390 ,rs9290530,rsl081968 6, ^7541099,^2097039,^1951215,^4268958,^3966085,^2202261,^35517 771,^57900 l,rsll949065,rs7211063,rsl0954646,rsl6866379,rsl0892676,rsl2 220092,rs4236378,rs6 967879, rs870968,rs4733583, rsl0198076, rs7573840,rsl2260688, rsl6869959,rs2319334,r s962517,rs2255663,rs2072051,rs7412307 ,rs2374993, rs6438472, rsl506452, rsl2717775,r sl0933034,rs926378,rsl915990,rs7139654, rs2284342,rs9685679,rs3751234,rsl7691826, rsl294245,rsl508628,rsl572872,rs3892375,rs7172590,rs8094280, rsl7212698,rs4938408 ,rsl7086144,rsl6946264,rsl0745469,rsl2673947,rs7123407,rs296 7578,rs2595201,rs983 350, rsl7622577, rs544358, rs295636,rs7648607, rs350965,rsl3334621, rs7911331, rs80397 96, rsl0418336, rs444288, rs7149473, rs4903573, rsl 6881539, rs4802620, rslll4832, rsl719 9833,rs744060,rsl378543,rs7775389,rsl0842176,rsl0853208,rs27 5360,rs761774,rsl716 1750, rsl545806, rsl0107215, rs7845141, rs910594 , rsl6867506, rs6475520, rsl2523231, rs6 075216, rs4952680, rs8141025, rs4918796, rs9393945, rsl3152601,rs9863323,rs4308918, rs

Table 13 -A-

6455443,rsl6908241 _f rsl7035871,rs8074185,rs7598676,rsl0827467,rs6724465,rs480124 2 ,rs7004405, rsl403264,rsl6921167,rs749134, rs9303597,rs2589155, rs6888272,rs4919513 ,rs2268721,rs983807,rsl0859526,rsl7095355,rs733212,rs2803245 ,rsll46304,rs7178760 ,rs864396,rsl6870406,rs2118370,rs4861175,rsl6846274,rsl47869 1,rs9583444,rsll6527 14,rsl2478744,rs786616,rs933006,rs4720876,rsl7187071,rs70336 33,rs2952322,rs92895 70,rs4941939,rsl0836176,rsl673411,rsll005618,rs8066880,rsll0 30328,rs2610383,rsl4 95139, rsl834025,rsl2089353, rs6675585,rs2961927,rs6009921,rs6583177,rsl7079163, rs 941039,rsl0174747,rsl6918960,rs221486,rsl0440348,rsl0999226, rs9811939,rsl864731, rsl0044838,rs2819997,rsl6910774,rs6825740 _f rs2936426,rs9823500,rs2524878,rs486703 5,rsl7094298,rs818441,rs609103,rsll098177,rs6747509,rsl21514 26,rsl6927279,rsl659 248, rs4622799, rsl7571811, rs4349149, rsl2589312,rs2643921, rs9883374,rsl939689,rsl6 832813, rs9831675,rs7766838, rsl2139274 , rs6136305, rs9343865, rs4732416, rsl 956880, rs 4841653,rsl0816182,rs757554,rs7862229,rsl6840510,rsllll711,r sl627329,rs839038,rs 1763430, rs4577275, rslO54066, rs2804085, rsl0023943, rsl520798, rs7639102, rs7580546, r sll760627,rs2168733,rsl6842389,rs733846,rs6008510,rs664310,r sll56318,rs563175,rs 1004970,rsl6859736,rsll044097,rsl329404,rsl0515155,rs4281802 ,rsll201269,rs794057 8,rsl2519369,rsl030303,rs6140301,rsll564233,rsl2196079,rs802 6741,rsl0243426,rs93 89049,rsl0975827,rs4903544,rsll25508,rs3821135,rsl456088,rs7 856030,rsl0151120,rs 7967572, rs2730589,rsll645898,rsl0515201,rsl045161,rs4917612, rsl537697, rs675734,r S2399341,rs4270401,rs7177863,rsl3280432,rs9525189,rsl7337503 ,rs3829495,rsl016271 9,rs9365399,rsl7273728,rs721575 _# rs226055,rs7726571,rsl7018590,rs729438,rs3771833 ,rsl0779033,rs4938638, rs781850,rsl0978606, rs9446997, rsl6960774,rsl0210419, rslll7 2570, rsl0184128, rsl0963684,rs4233961,rs7300810,rsl0780673,rs2293177, rs9401575, rs 4438803, rsl7334674, rs4455810, rs4859227, rs6504425, rs7830138, rsl828169, rs202577, rs 17704083, rs203466, rsl701850, rsl 996050, rs7811003,rs6957270,rs43108, rsl998587,rs70 86978, rsl7670802,rs4974178, rsl2681967, rs401519,rs6835691,rs9543632, rs9910773, rsl 2284994,rs6849245,rs4897103,rs4570897,rs7599431,rs4655138,rs ll056533,rsl7072628, rsll601486,rsll060375,rs7115199,rsl868629,rsl2409177,rslll72 135,rs9449623,rsl311 1705, rslO125469, rs2406853, rsl 63800, rsl507150,rs9633679, rs875976,rs2861638, rsll87 718,rsl7183738,rsl6844715,rs8077944,rs7960444,rs7616317,rs47 47087,rs9515692,rs60 7454 l,rs252026,rs2814863, rsll999227,rsl3273164,rs924571,rsl7679127, rs7899454, rs7 589604, rs312692,rs9342529, rs6758667,rs7560745,rsl7068,rs4707664, rsll053748,rsl04 91172,rs7310000,rsl3274253,rs501241,rs7374776,rsll711241,rs6 756979,rsl7835197,rs 11084054, rsl2185723,rsl540373, rslO794057, rsl7057596,rsl2653975,rsl0978767, rsll80 2362,rsl7825774,rsl7125331,rsl0965049,rsl7051547,rsl2074413, rs2597301,rs241786,r sl7101003,rs6973238,rs2306743, rsl7527979, rs9460408, rs3943074, rs7190066, rsl246942 0, rsl 6977367, rs2466515, rs2225373,rsl7668415, rs4140729, rs9447668, rsl7533041,rs793 3787, rsl7240055, rs2166049, rs6554677, rs4652983, rs4840567, rsl0953034,rs2689229, rs6 754317,rsl509453,rsl966480,rs7557992,rs9329136,rs9800255,rsl 0512601,rs7485562,rs 11839700, rsl7155336,rsl6942146, rs9471753, rs7857732,rsl0872865, rs6851156,rsl68833 99, rs4908327, rs3106807,rs9836959,rsl0079164, rs2816661, rs9499111, rs7746105, rs3754 7,rs330885,rs6958747,rs2376727,rs2624119,rs9809408,rsl249475 1,rs4695152,rsl70006 32,rsl2567456,rs819952,rsl542615,rs24401,rs4539982,rs7123232 ,rs828595,rslll03148 ,rs249600, rs6445693, rs3809471, rs4713604, rs360275,rs4745110,rs6463973, rs6759476, r S2306444-, rsl 6827187, rs8009311,rs2004837, rs2897390,rs4318822, rs2278392,rs7217610, rsl0922963,rsl7041557, rs7725177,rs2300820,rs755136,rsl2567930, rs7258943, rs453161 5,rsl33916,rs6510605,rs701822,rsl416236,rsl3131164,rs693282, rs326091,rs2720564,r s2153324,rs9390927,rsl2289897,rs4142064,rs3788964,rs5756767, rs6658526,rsll237796 ,rs573301,rs6436555,rsl6927034,rsl7720153,rsll641790,rs67613 54,rs4722789,rsl7382 396,rs5995155,rsl7584049,rsl2471593,rs2286297,rs2197964,rs67 51734,rsl7049579,rs9 646155,rs9586343,rsll250092,rs9417900,rs9862261,rs6700782,rs 6974091,rsl2107009,r s2870108,rsll244605,rs4861722,rs4370554,rs8066722,rs7816225, rsl0032186,rs7907054 ,rs2365851,rs825672,rs6495252, rs2278006,rs7697133, rslO9O1402, rsll652097,rs39667, rs7602191,rsl2508042,rs8095325,rs2039982,rsl940694,rs333472, rs6659420,rs4707991, rs563511,rsl7094134, rs592396,rs2128490, rs6861390, rs9381454,rsll021122,rs7548737, rslO267684, rsl0502300,rs4977237, rsl281001,rsl7314566, rs7697039, rs796195,rs780431 8,rsl0210162,rs9553516,rsl3281515,rs598672,rs2260430,rsl5084 03,rsl0820835,rs8107

Table 13 -5-

361,rs9494087,rsl204370,rsll086907,rsl879228,rs7758611,rs309 058,rs7809742,rsl984 082, rs6448436, rs 6974900, rs2040522, rs2009654,rsl2691747, rs7664024, rs9393078,rs301 564, rslO768011, rsl7667121, rsl0502315, rs2155411, rs7310068, rs579878, rsl0036787, rsl 1801103, rsll58864,rsl322204,rsl389726,rsl0037115,rs4633874, rs7097320,rsl860075, r sl570092,rsl0987074,rsl3236122,rsl43577 I,rs4853939, rs4784730, rs4887531, rs2933135 ,rs4823590,rs9390170,rs7762412,rsl7012898,rsl3143454,rs80089 63,rsll87643,rs75748 87,rsl257101,rs3861439,rs4720536,rsll767025,rs3800307,rs7231 876,rs9332431,rsl009 213, rs633719, rsll040338, rsl 6877429, rslδ 60776, rsl7459026, rsl858627, rs4760615, rsl5 68958,rs9367268,rsl0879058,rs2237342,rsl014547,rs4911241,rs3 009560,rs501796,rsl0 33611, rs3121161,rs2301479, rsl2708423,rsl7212326,rs6866185, rs6598553,rs261774,rs6 802863,rsl2639242,rs7371503,rsl013467,rs663261,rs2621452,rsl ll63192,rs4446702,rs 17026944, rs2160913, rsl2044442, rsll601420,rs4979316, rsl0197852,rs7185033,rs773920 9, rsl 6955101, rs9997385,rs8032343, rs4897398 ,rsl264702,rsl553841,rs3747113,rs80141 35,rsl7013720,rsl867347,rs265332,rs238597,rsl0880155,rsl6846 050,rs7822232,rsll22 4967,rs2110903,rsl0410768,rs4942999,rsl666555,rsl0951356,rs4 915802,rs4748453,rs4 867939,rs7918619,rs7570763,rs2939616,rs925893,rs6445044,rs93 0125,rsl0789303,rs65 76251, rs9842903, rs8029120, rsl 6860127, rsl534378, rsll856273,rs8031341, rsl 6963382, r S7073683,rsl524716,rsl414911,rsl2328637,rsl041017,rsl7070904 ,rs4734305,rsl001037 ,rs9678628,rs576952,rsl6928964, rs6849536, rsl391471,rsll650955,rsl420106,rs946983 6, ^7230770,^7128036^3749115,^2100360,^2918070,^9917392,^991053 0,^7766508 ,rs7357260,rs269866,rs2512674,rs2228069,rsl98142,rs7501378,r sl566770,rs596197,rs 16842934, rsl7781533,rs898194, rslll99227,rs6821554,rsl0972350,rsl0841474, rs963380 3,rs3829536,rsl367637,rsl560026,rs7157149,rsl7072836,rs24834 91,rs2730517,rs72289 30,rsl7072902,rsl0951934,rs7200634,rsl2413862,rsl6823850,rsl 550434,rs2957471,rsl 0475884, rs2068061,rsl0776787, rsl58862, rsl2465727, rs7677888, rs7501951, rs2396463, r sl2465448,rsl0798912,rsl7007439,rs8176373,rsl0929740,rsl0816 972,rsl324868,rs2290 037,rs7582123,rs4626964,rs6095248,rsl992988,rs734108,rs29656 06,rsl7039386,rsl682 802, rs979307,rs4653206, rsll803639,rs7922670, rslO953111, rsl 6938251, rsll264233, rsl 0794012,rsl7482908,rs4886041,rs4958945,rs6583239,rs221289,rs ll016531,rs9641728,r sl2933937,rs5755311,rs6534444,rsl2525980,rs4932445,rs9297556 ,rsl0934716,rsll 9959 99, rs7993043, rsl282970,rsl0149991, rsll803410, rs6574054,rsl7361892, rsl075873,rsl7 117531, rs3796096, rsl6826565, rs7304120, rs 11006856, rs8087837, rs3935870, rsl36213, rs 11656615, rs 16842839, rs8007552, rs 10090705, rsl 1068984, rs 6509215, rs4821197, rs 124857 06,rsl0994259,rsl7019763,rs2295394,rs3905173,rs464466,rsl760 376,rs903061,rs80255 50,rs3814014,rs4243858,rs7743815,rsl7054399,rs4599356,rsl338 5042,rs6499868,rs986 6591, rs2274890,rs7917826, rs7805317,rs350662,rsll046211, rs585787,rs840194, rslO221 619,rs2250712,rsl6855893,rs8031867,rsl7007771,rs9385717,rsl2 237062,rsl6898325,rs 9573196, rsl7763231,rsl7754266, rsl7693752, rsl0093908,rsll036615,rs3981333,rsll004 185,rs7349784,rs6951949,rs7334256 _# rs930296,rsl6844152,rs7730428,rs4470994,rs5172 49, rs2048805, rs7671360, rs4926453, rsl941115, rsll665492, rsl522096,rs2063222,rsl085 3672, rs6535987,rsl0990708,rsl7638434, rs2376196, rsl6979595,rsll711286,rsl0085484, rs7643101, rs3992620, rsl873504, rsl 6967221, rsl0502497, rsl6972853,rs6585041,rsl3425 741,rs2302963,rs2720352,rs500643,rsl7706123,rsl0797677,rs203 9942,rs2262774,rs285 9420, rsl522749, rsl7508058,rs4271787, rsl465780, rsl7824783,rs4615068, rs798754, rsl7 841422,rs394849,rsl0990985,rsl62675,rsl6824790,rs2015720,rsl 359138,rsl7491620,rs 2246842,rs6750609,rs4842947,rs4850669,rs751008,rs4404084,rs9 292848,rsll891079,rs 9859473, rslll72333,rs648438, rs727984, rs2449733, rs6846013, rs542671,rsl482648, rs92 90134, rs4853378,rsl0897158, rs4964181, rsl 1691617, rs7620389, rs2052735,rsl750047, rs 6716296, rs7432306, rs6710702,rsl0097541,rsl2044852, rsl0017569,rs4925109, rs6070529 ,rsll211101,rsl7127600,rsl943560,rs6999724,rsl6862989,rs3209 18,rs8021846,rsll710 750,rsl0409609,rs264263,rs6506895,rs6730724,rsl2528047,rs902 967,rsl3238408,rsll9 70772, rsl7829436, rslll 62698, rs4144888, rsl395504,rsl0470062,rs2052058,rs9616936, r sll988033,rs616114,rs9878978,rsl7083873,rs3765795,rs397476,r s524646,rsl2543159,r s4813669,rsl7545756,rs330299,rs786019,rsl675128,rs7640744,rs 8028382,rs7007686,rs 16949270,rsl2403009,rsll633450,rs4790589,rs993253,rsl7062140 ,rsl045453,rs914464, rs271452, rs4947636, rsl7610212,rs234363, rs2904040,rs2932537,rs3893215,rsl2716433, rs2056506,rs4413039,rsl550444,rsl7380508,rs6665853,rs738809, rsl2970735,rs2913973

Table 13 -6-

,rsl2590815,rs2897847,rsl7584022,rs4777888,rs4951552,rs83526 5,rsll938418,rsl2697 870, rs2742461, rs641967, rslll91193, rsl 1062678, rs3212336, rs4669589, rsll241888 ,rslθ 236205, rsl2328061,rs2868891, rs4799014, rsl39895, rs293638,rs776291, rslll80445, rslO 066782, rs2965967,rs488137, rs2624175, rs4941973, rsl7140652, rs6706646, rs2470392,rs9 635886, rs4716838, rslO984920, rs9503410, rsl 6841187, rsl238290,rs4148077, rs225980,rs 1442175,rsl7407137,rs6909569,rsl038990,rs3755326,rs4858051,r sl6859404,rs751940,r s6487101,rs3805698,rs7740208,rsl7044290,rsl644505,rsll854060 ,rsl0502687,rsl77639 15,rsl0850886,rs2722647,rs459955,rs2978340,rsl780731,rs69609 65,rs7571469,rs66144 6,rsl927208,rs9463076,rsl0992543,rs418891,rsll211631,rsl7368 880,rsl943413,rs7702 763, rs4756377, rs6993502,rs4876946, rs7171364, rsl2005428,rslll22861, rs4625425, rs21 58134,rs6119747,rs7590683,rsl0082687,rs2076589,rs3213454,rsl 0781147,rs7241677,rs 16859370, rsl7758597,rs956044 O, rsl2563134,rs7792073, rsl2547053, rsll34095, rs467280 3,rs9567578,rs2044868,rs415786,rsl0149714,rsll072570,rsl3634 05,rs4842479,rs29645 57,rsl051640,rs2101467,rsl0951528,rs9836014,rsl472721,rs2113 85,rsl844080,rs42564 14, rs6667223,rsl7670898, rs7125378, rs2167769, rsl891643, rs8072395,rsl0423232, rsl74 74534,rs3001915,rs3796587,rsl36380,rs2687544,rsl2307593,rsl8 65290,rs2221331,rsl0 00738,rsl821443,rsl0414193,rs28539017,rs8006589,rsl0956215,r s4112805,rs7755236,r sll983951,rs3777385,rs7602215, rsll617799, rs4792953, rs4576925, rsl468092, rsl68716, rs7619198, rs7246707, rsl937136, rs7533905,rsll836178,rs3794089, rs4730779,rs7843878 ,rs4731517, rsl3133106, rsl7518487, rs6546975, rs2572000, rs7965247, rsl7040704 ,rsll90 2906,rs4374540,rs9869080,rs905010,rsl0986743,rs9959465,rsl75 34963,rs4569500,rsl7 710446,rsl2952857,rs7295162,rs6957876,rs5760780,rsll616577,r s4666643,rs4081753,r s4421879,rs2092898,rs4289434,rsl6857885,rsl6894640,rs6698901 ,rs7235709,rsl685311 4,rs933511,rsl521566,rsl7210001,rslll55342,rs7919486,rsl9539 33,rsl0859684,rs2601 163, rsl2707060,rs9343710, rs6899322, rs9289587, rslll71550, rsl425029, rs4832615, rs76 08257,rsl0774843,rsl7770834,rs684215,rsll089722,rsl0493999,r s4143438,rs4493573,r sl901640,rsl6887248, rs9353364,rs2460691, rs2865099,rs2452767, rsl7481647, rs6858269 ,rsl7051819,rs8086549,rslll52303,rsll082594,rs451743,rs93043 47,rs4800099,rsl4744 00,rs577328,rs2403313,rsll034845,rs4491860,rsl0737278,rs4745 006,rsl3128237,rsll0 42027,rsl0960002,rs752724,rsl0880439,rs5012630,rs2225505,rs6 876647,rsl0789442,rs 10875098, rsl376559,rs255258,rs6688031,rsl939066,rs4680868, rsll205444, rsl575692,r sl7694988, rs4364228, rs6745464, rsl7674783, rsl6886277, rs7972255, rs622274,rs2661778 ,rsl2442697, rs9301988,rs772780,rsl2656767, rsl 931089, rs2273758,rs984682, rs2243823 ,rs349973,rs994224,rs9385403,rsl7029408,rslll45806,rsl710746 9,rsl3118487,rsll707 857, rsl792229, rs8066114,rsl0823724,rs6093392,rsl0243198, rslO875469, rs2248221, rs2 562059, rs8038691, rsl2562587,rsl7820772,rsll757092,rsl7473451,rsl6999774,rs958 263 4,rsl533269,rsll997,rsl572297,rsl2198961,rslll59175,rs244709 5,rsl0494007,rs23 ^" 959 87, rs579392, rs28483233, rs4940195, rsl7544450, rs2527188, rsl3355325,rs6430505, rslO8 59103,rs306713,rs4847116,rsl0867409,rs849161,rs6548485,rs407 4568,rsll749439,rs69 54851, rslO43669, rsl7437560, rslll20153,rsl2976023, rsl0735607,rs394682, rs671803,rs 1269704,rsl498424,rsll489759,rsll872614,rs6869793,rs9369083, rsl7247566,rs6778471 ,rs2036113,rs695625,rs4737,rsl659495,rs6997661,rs7573696,rs3 934888,rs215759,rs23 25499,rsl0786198,rsl6827546,rs7658319,rsl0120949,rs6594409,r sl537542,rsl450353,r s8032120,rs277655,rs3802252,rsl389778,rs7204400,rs7586789,rs l7110482,rs7640765,r s4657816, rs759071,rsl0430826, rs2050518,rs3924496, rsl6919782,rsl7249642, rs9918811 ,rsl431867,rs797212,rs3764922,rs7789361,rsl444547,rs480544,r s7245504,rs7285756,r S6800998,rsl0964447,rs2759714,rsll80099,rs4336920,rs2164322, rsl7047387,rs7934133 ,rs7875262,rs530991,rsl0052284,rsl912806,rs777245,rsl571367, rs6982175,rs9532378, rs249008, rs533116, rslOδlδ 651, rs978671, rsl7157919, rsl2291881, rs4148542, rs9312704, rsl883774,rs7716272,rslll35570,rs2748800, rsl0823003,rsll626616, rs2603275, rs46883 2,rsl0887058,rs2109683,rs6505392,rsl7305779,rs7631197,rs4242 623,rsl7458775,rs221 87 l,rs7031607,rsl577925, rs9666463, rs 9826059, rs4521246, rs219339,rs9865772, rslO824 914, rs600790, rs969987,rsl2126442, rsl 6902816, rs671101, rs2196556,rsl027311,rsl5694 37,rsll599497,rs9294951,rs7089580,rs4855753,rs752206,rsl0169 949,rsl868686,rsl705 8376,rs632683,rsl2615094,rsl7709596,rsl428355,rs6894815,rs45 52931,rsl787777,rsl9 91522,rs4120131,rs4840153,rs4940679,rs4892130,rs2190347,rsl7 420591,rsll087340,rs 12238895, rsll917205,rsl76411, rs3780830,rs8175522,rs2597240,rsl382712,rs2700904,r

Table 13 -7-

s242270,rs4869025, rsl2915980, rs7335910,rsl0042985,rs6060047,rs581633,rs7614383, r s7148264,rsl6944523,rsl2128220,rs7234478,rs9790670,rs9714197 ,rs3752770,rs9341791 ,rsl7270394,rs4680060, rsl401313, rsl402671, rsl 1172387, rs6710579, rsll 646782, rsl684 9973,rsl3045986,rs965472,rs3909823,rsl2701757,rs7749235,rs68 54709,rs755904,rsll6 30493,rsl256093,rsl018051,rs938225,rs7035055,rs7514606,rs218 5654,rsl7116367,rsl0 245130,rs9821793,rs478843,rs940744,rs9654286,rs6495697,rs223 6241,rs3923952,rs684 2486,rsl7061055,rs6533940,rs4754743,rsl7441237,rs9319997,rs7 021837,rsl884137,rs7 450287, rs9972951,rsl0981115,rsl7229044, rsl460665, rsl4488, rsl7698905, rs7026968,rs 17086184,rs761979,rsl992461,rsl288351,rs7855520,rsl6969437,r s7643865,rsl481262,r sl2703863,rsl2979795,rs2034312,rs9548973,rsl7019255,rs803556 1,rs4793765,rs999938 3, rsl7131819,rs6874274,rsll030271,rs4980801, rs2045729, rsl292339,rs4873770, rs5003 66,rs2014769,rsl7170032,rsllll7277,rs8137408,rs2452601,rsl08 78356,rs493713,rs720 3554, rsll734993, rsll67309,rs2548553, rs6782373,rs9956331,rsl77458, rsl7686332, rs24 48144, rs4693295, rsl2676051, rs8097281,rsl7680989, rsll 678596, rs6482455, rsl6876775, rsl2467411,rs4814369,rsl3355233,rsl6850914,rs7712675,rsl0870 505,rsl2552060,rsl77 6566, rs4959502, rsl346957, rs7237421,rsl967965, rs7237226,rs34783515, rsl949499, rs77 9330, rs4652772, rsl208683, rs6487231, rs844187, rsl 6985435, rsll802413, rsl0037966, rs6 864049,rslll39785,rs4632066,rsl844292,rs2469203,rs2344918,rs l669754,rs6466669,rs 17024923, rs7492267, rs9360967,rsl0103809,rsl775831,rsl7077583,rsll010958,rs37570 0 7,rs2124660,rs269648,rsl636942,rs7706272,rsl996913,rs4319703 ,rs7080786,rs2863747 3,rs716688,rs7664551,rsl7526294,rs7685626,rs4985452,rs407850 5,rsll04852,rsll6792 80,rs7752775,rsl2100645,rsl6832656,rs4439664,rsl0235324,rsll 973890,rs9395406,rsl 2965571, rs6413416, rsl7240121, rs9523906,rsl6955523,rs4342964,rsll779650,rs9293518 ,rsl2508912,rs671802, rs4833561, rslO423829, rs6784771, rsl0955242,rs6112640,rs68282 06,rs4644628,rs7637321,rs2631400,rs7937026,rs7896374,rs20388 5,rs4794497,rsll0002 01, rs4837521, rsl2141389, rsll683762, rs7970581, rs875214,rs7395884,rs4268118, rs2280 635, rsl463869, rs2124622, rs4608457, rsll050512,rs8098113, rs2655364, rsl730164,rs230 5745,rsl0755834,rs6072436,rsl2713377,rsl324087,rsl0853621,rs 2351953,rs852499,rs8 009160, rsll004060, rs2570500,rs322896,rs7837952, rslll6346, rslδδ 68423, rsl7119072, r sl7819911,rs6534682,rsll764693,rs7619484,rsl0460806,rs796941 2,rs7807451,rs776285 2,rsl0803535,rs728904,rs7138155,rsl58706,rs9497869,rs4954510 ,rs755600,rsl7173656 ,rsl0953220,rs4924012, rs2304672, rs7085037,rs6836534,rsl0751621, rsll245962, rs6749 165,rsll951246,rs253136,rs334445,rsl7287085,rsl7050806,rslll 57438,rsl330286,rs69 17860, rs6989764, rsll019031, rs2038018, rs7667572, rs4430440,rs743931, rs6931955, rs91 9033,rsl2427058,rsl868466,rsll765437,rsl6970094,rs8059305,rs l53346,rsll55137,rs7 619259, rs830957,rsl453094,rsl6881347,rsl349432, rsl204842, rs6457792, rsl261728 l,rs 7242135, rs2298726, rs6737883,rs7700926,rs7864987, rsl7470840,rsl524875, rs905770,rs 12454802, rs2320730,rs6922974,rs9832361,rs2278093, rsl 6864835, rs9370066,rsl33666,r S7824823, rs9292114,rs220030,rsl7740582,rsl7047354,rs7240771, rsl 6837131, rs321908, rsl2462204, rs7622187,rsl0943006, rsl526727, rs7740853, rsl0983184,rs3135093,rslll23 900, rs7946841, rs2220831, rs518277, rs3807156, rslO9116O4 , rsl915297, rs4628279, rs 6118 390,rs2228230,rsl7012525,rs9856460,rsll009626,rsl2959881,rsl 496887,rs4678649,rs4 854559, rs6050447, rsl2951391, rs6508182, rs895882, rsll635852, rs2419737, rsl7692546, r s2122922,rs7730302, rsl 6836493, rs2057252, rs9661103, rs299630, rs7830114, rs 6101893, r s582397,rsl0950252,rs9503,rsl3040647, rsl2972158 _# rs6825091,rs7615969, rsll232131,r s2060562,rsl342311,rsl2995986, rs4760510, rs3807359,rs4798276, rsl7824408, rsl713859 6,rsl72407,rsl437950,rs9370349,rs2363717,rsl2705305,rs696735 8,rsl0820938,rs76930 44,rsl3317787,rsl7294204,rsll096655,rs4942924,rsl462309,rsll 038695,rs2162711,rsl 6992162, rs696434,rs401573, rsl2334162, rs7203768, rsl516584,rs470822, rsl 919894, rs25 62126,rsl7144119,rsll009068,rsl532108,rs7332129,rs35653399,r sl3179161,rs4923544, rsl2756603,rs6815262,rsl2663112,rs4602638,rsl424151,rsl70953 03,rslll05757,rs7676 961,rs398157,rsl204005,rsl7778698,rs7093445,rs4658411,rs4840 437,rs4657976,rs8076 496, rs6979339, rs4389259, rs4652871, rs7255848, rs8190581, rs9522597, rsl437353, rs8009 420,rsll216080,rsl3021961,rs7422977,rsl726374,rs2718453,rsl0 17962,rs2424502,rs65 33344,rsll077325,rsl7008965,rsl442650,rs7224640,rs7269525,rs l0431948,rsl009090,r sl0060315,rs2526303,rs2809603,rs834054, rsl7303597,rsll90700, rsl 6868525, rsl292836 2,rsl7098978,rs2135902,rs8042667,rs6773706,rsl0836978,rs2139 778,rsl594570,rs7544

Table 13 -8-

212, rsl864759,rs6667261,rs2345589, rsllO21216, rs4518265, rs8083374 , rsllO72213, rsl 6 959544, rsl7801314,rs35425624,rs2057992, rsl7165333, rsl0956369, rsl2295488, rsl 68473 37,rsl0906050,rs4842275,rsl0085515,rsl0739777,rs2280122,rsl9 9097,rs4977188,rslll 60805, rsl2630349, rs643319, rsl7007023,rsl354191, rs7994632, rs4802119, rsl2908526,rs 17779908, rs9875154,rsl944054, rsl0830989,rs6422001,rsll677047,rs2183116,rsl006265 9,rs7750861,rs6508086,rs8029892,rs2379609,rs4711716,rsll2296 01,rsl0805659,rslll7 7594,rsl3278460,rsl7215701,rsl214464,rs339656,rsl6928966,rsl ll03770,rs9784937,rs 10777965, rsl2047301, rsllO66551, rs4809987, rsl0956904 , rslll62482, rsll220556, rs2924 62, rsl6854665, rsl2426396,rsll943338, rs7222014,rsl0262102,rsl7629069, rsl83140,rs7 840674, rsl501071,rslll57766, rslO760778, rsll083288,rs4931245, rs6945850, rsl7075279 ,rs8051268, rsl7583742,rs3867180,rs7901082, rs2467155, rs7115359, rsl0221723,rs43172 16,rsl0802426,rsl2100451,rsl6919192,rsl0129954,rsl494053,rsl l575309,rsl3180928,r s4509144,rsl7158985,rsl323375,rsll957546,rs3743896,rs6012564 ,rsl6843099,rs612934 6,rs2984834,rsl2813450,rslll48739,rs4322428,rs6756245,rs2908 967,rsl2090448,rs691 9121, rs7653848,rs 6421998, rs7621575, rs392013,rs4972176, rsl476112, rsl66394,rsl2216 074,rsl7601834,rs9968804,rsl533819,rs942075,rsl7118741,rsl27 07907,rs9352915,rsl6 526,rs4624587,rsl7287370,rs6824313,rs3782257,rslll50730,rsl7 817919,rs577367,rs81 03254,rs9655470,rsl7073740,rsl0001582,rs409649,rs3018592,rsl 6922543,rs6997943,rs 11712672,rs6899845,rslll87785,rs2807685,rsl3214455,rs806876, rs4519880,rs7817465, rsδl 90371, rsl3019783, rs28696845, rsl562855, rsl0839633, rs4820550, rs7845032, rsl2706 415,rsl0992722,rsl0431642,rs7259472,rsl377451,rsl6961883,rs2 176870,rsl3223119,rs 7783, rs3774907, rs7685984,rs9518907, rsl0001263,rsl0942370,rsllll7003,rs4677905, rs 17102644, rsll925209,rs8005768, rs6571322,rs7785988,rs4968755, rs7165405, rs3845800, rsl3378689,rs390978,rs537571,rs7573145,rsl7287976,rs9684799, rsll694376,rsl013207 7,rsl0883843,rs7833605,rsl231521,rs4942864,rs7701145,rsl2280 725,rs2341883,rsl697 3647,rsl2290076,rsl0761741,rs428121,rsl2131145,rs8138460,rs7 323436,rsll23065,rsl 7121768,rs4512469,rs6559902,rs5742848,rsl7670565,rs4312703,r s2973403,rs2533878,r s2216924,rs4606034,rs6544744,rs2086765,rs3934409,rsl7186996, rsll258843,rs4668211 ,rs746423,rsl0183544,rsl0796267,rs2300083,rs848481,rs4925811 ,rs3755579,rs2535737 ,rs6872396,rsll733039,rsl346950,rsl3173555,rsll817689,rsl095 5255,rs4308924,rs645 5312, rsl0138222,rs6461684, rsl0780348, rs6494212, rs7821631, rsl400174, rsll249242, rs 9369346,rsl6907708,rs6497993,rsll65227,rs632824,rs849786,rs2 421873,rsll778824,rs 16975879, rsl7334651, rsll041987, rs4234254,rsl0110693,rsl917673, rs4765420, rs5850,r s2195987,rsll649174, rsll221541,rsl0125054,rs2031901,rs6831790,rs2711953, rs389107 5,rs9657633,rs618131,rs478442,rs4384653,rsl0016021,rsl231132 7,rs3920297,rs498604 8,rsl0187195,rs2635447,rs7160695,rs4469299,rsl2965816,rsl206 726,rsl7747706,rslll 49796,rsl583891,rs6593078,rs9866054,rs4451275,rs7589480,rs31 0269,rs9453462,rs404 5836,rsl0431384,rs9296302,rs2411222,rs6448920,rs7870405,rs48 66687,rs2800980,rs25 48321, rs770710,rsll097119, rsll 665154, rs775455, rs7743511, rs8004318, rsl7612303, rsl 0965403, rslll74250,rs997554,rsl51923,rs6699758,rs7326195,rs9856736,r s9829719, rsl 1025639, rslll88203,rs804200,rs4241722, rs9521699,rs6500531,rs6455261, rsl409248, rs 10461166, rsllO31851,rs7620921, rs7990962, rs7155910, rs4493136, rs4449085, rslO798473 ,rs6441374,rsl7203523,rs9750635,rs2238591,rs33999009,rs97164 9,rs9572542,rsll9528 02,rs6937607,rsl7304039,rsl285466,rs3935472,rsl878448,rsl019 4516,rsl0055569,rsl7 062431, rsl7028957, rs6510207, rs4850625, rs6099309, rs2214147, rs2787975, rs6947512, rs 848942,rs3772175,rs6861915,rs339785,rs2287420,rs9953836,rsl4 70644,rsl0794865,rs3 743005, rs2444891,rs9293471,rsl6841037,rs4706769,rs788805,rs4949333, rs4869355, rsl 7148449,rs600120,rs7147119,rsl853310,rsl0745937,rsl945116,rs 2764387,rs325929,rsl 6937010, rs28648624, rsl7707014,rs6898323, rsll596733,rs839878,rs6905494, rsll205175 ,rsl278776,rs776107,rs6679913,rs936849,rs9517626,rs211412,rs 615672,rsll942138,rs 6992145, rsl0938907,rs6745116, rs7619926, rs9368571,rs6595483, rs6842513, rsll208960, rsl0755066,rs732568,rs4664302,rs919147,rs8008996,rs6492725,r s2695220,rsl0062706, rsl492899, rslll30137,rs3741705, rsl7210261,rsl7833004,rsll827258,rsl474986, rs2190 059, rs654904 I,rs6894128, rsl3107428, rsllδ 69921, rs7217216, rsl896979, rsll602565, rsl 778365, rs4597724, rs2617091, rs508094 , rsl0937044, rsl0252734 , rs7119917, rs9401937 , rs 7339280, rs924952, rsl386283, rs2522843, rsl494578, rsl0988804,rs9859166,rsl2278731,r S3017684, rs6947594, rs9466180, rs6922340,rsl0970083,rs7039670,rs6920901,rsl0997908

Table 13 -9-

,rs7546123,rs6923951,rs254675,rs5993715,rs6727859,rs925759,r sll073530,rs2303873, rsl0772414,rsl0837876,rsl0852359,rs221592,rs6734356,rs204488 5,rsl0951674,rs38648 32,rs2299305,rs4733792,rsll857650,rs2905986,rs597026,rs98867 1,rs9285876,rs733020 6, rs4690336, rs430746, rs2029585,rsl7419032, rs3733769, rsl0739335,rs6064322, rsl7040 969, rsl815070,rsl202397,rsl499569, rs7233570, rsl 6917973, rs2679340, rs9298278, rs677 6913,rs8012854,rsl509629,rs9646945,rs2454962,rs6982224,rs770 1756,rs6460544,rs935 9570,rsl0937436,rs6459187,rs7149126,rs3951794,rsll922760,rsl 0025071,rs31448,rs47 87164,rs313951,rsl2693385,rs877222,rs4267261,rs2348741,rs724 0410,rsl7773805,rs98 45197,rs7729729,rs6476005,rsl0983408,rsl6909004,rsl0879876,r s2158997,rsl2305653, rs243172,rsl0873205,rsl2952168,rsll023294,rs4935086,rs486626 3,rsl0249746,rs22424 58,rsl0016003,rs520379,rsl958882,rsl0098291,rs2178820,rsl597 245,rsll633914,rs802 2447,rs4821231,rsl7633799,rsl544492,rs260445,rs719875,rs8970 67,rs2564086,rsl2620 943, rsl564031,rsl6865460, rsl0495582, rsl446542, rslO495722, rsl7046399, rsl881396, rs 2280404, rs564310, rslO490455, rsl7389879, rs3765598, rsl861434,rs6746058, rs4455206, r s3088359,rsl0495951, rsll57876, rslO490232, rs952167,rs9309291,rsl0490247, rs721250, rs76674, rsl7008940,rsl049617 l,rs9309484, rs7597923,rsl7013999,rsl0496211, rsl26233 13,rsl0520355,rsl3394583,rsl0496320,rs2030259,rs9309647,rs40 24607,rs2030693,rsl7 030514, rsll893695,rs2577594,rsl430304, rs967895,rs982909,rsl7045365, rsl559509, rsl 124830, rs330768,rs2901018,rs2124311,rsl0496655, rs841448, rsl317989 _f rsl7744220,rs9 287450, rs2030954,rsl7469669, rsl427500, rs987214, rsl561515, rsl528839, rs4667399, rs4 130558, rs2290816, rsl028217,rs2444263, rsl0497084, rsl2693415, rsl582842,rsl960289, r sl8O7921,rslO490005, rs2389549, rsl227921, rs2218915,rs2807562,rs4597482, rsl0497364 ,rsl816811,rsll674895,rs9287975,rs970797,rsl0494252,rsl04974 98,rsl0497534,rs7556 967, rs288298,rsl0497634, rsl443023, rsl7431742, rsl386515, rsl992930, rsl0203398,rs67 07560,rs291406,rsl440059,rs6738407,rs6704641,rs203757,rsl561 296,rsl0197159,rs675 8081,rs7589549,rs2193230,rs2891733,rsl0498121,rsl250937,rs38 20763,rs4674965,rs67 10935, rsl7321741,rsl0498256, rsll 90452, rsl749409, rs4816165,rs237640, rs910952,rs22 95509,rs363004,rs6040373,rsl7225634,rsl570484,rsl0485549,rs6 080835,rsl0485587,rs 2143856, rs6075709,rs926619,rs6049254, rs3213183,rs819144, rsl0485654, rsl7820549, rs 17333555, rsl 981429, rs6018471, rs4656856, rs6021247, rsl0485620, rsl293381, rs3852929, rs3753381,rs259987,rs2426960,rs418215, rsl 997579, rs2297248,rs2824197, rs2824585, rs 17002640, rs2825652,rs2155887,rsl037825,rsl0494377, rsl699640,rs2000488, rs2830911, rsl81706,rs2831443,rs2840266,rsl28592,rs2833129,rs720935,rs2 834371,rsll700684,rs 2049903,rsl014840,rs2835301,rs2835931,rs2836181,rs2837006,rs 2837818,rs928874,rsl 541290,rs762418,rs391815,rsl7432784,rs765744,rs4822998,rs224 0366,rs6427082,rs713 686,rs5756453,rs2899293,rsl38368,rsl010169,rs7287734,rsll083 64,rs5768143,rsl2488 182,rsl899780,rsl430009,rsl7233898,rs2928079,rs2454509,rs931 0411,rsl7040817,rs27 33500,rs7627715,rsl0510539,rs892941,rs322680,rsl449292,rs495 5348,rs2035559,rs751 8039,rs9311270,rs6808854,rs6441990,rsl0510761,rs3821412,rs96 7331,rs612089,rsl374 678,rsl0510951,rsl563544,rs6782474,rs7515041,rsl288701,rsl70 09414,rsl440622,rsl0 511116, rs588859,rs998206,rsl0489474, rs418874, rs227984,rs949631, rs6770896, rs99829 l,rsl7700761,rsl0511187,rsl375514,rsl0511200,rsl82948,rs2141 621,rsl0511254,rs269 8351, rs2399418, rsl054263,rsl903431, rs6798938, rs7638876, rsll 929078, rs4831130,rs67 87168, rslO511378,rsl410588, rs 6782002, rsl515577, rs7629297, rs702030, rs2999051, rslO 494532,rs9289457,rsl501195,rs6774289,rsl0513002,rsl0513030,r s201676,rs601032,rs8 79716,rsl0513209,rs2375284,rs575834,rs6808403,rsl0935775,rs3 846074,rs497793,rsl9 17777,rs2043108,rs3925065,rsl399903,rsl6834616,rsl390041,rs6 16545,rsl0513669,rs2 422084, rsl0513733,rsl0513788,rsll711828, rsl365111,rs3796283, rsl515078,rsl019606, rsl920266,rs951704,rs997552,rs966199,rs553280,rs7663514,rs74 37940,rsl6892992,rs9 75229, rs33985463, rslO489115, rsl0012313,rsl503868,rsl380272,rsl0489099, rs6840816, rsl0000992,rsl0033618,rs4504846,rsl0517265,rsl2644671,rsl511 859,rs975286,rsl6988 240,rs6531635,rs337634,rs4590083,rs2347043,rsl492839,rs76684 05,rsl0517164,rs3934 674,rs28658460,rs9992300,rsl0023088,rs2028437,rs349180,rs335 314,rs2063419,rs8845 11, rsl 115919, rs407334 l,rslO516761, rs6838659, rs342457, rs6829938, rs2119322, rs42821 34, rslO516815, rsl921679,rs2036081, rsl 6835629, rslO516885, rs35538025,rs2866182, rsl 0516463,rs3774959,rs9307294,rs6665228,rsl994634,rsl960734,rs 2041179,rs3796937,rs 716394,rs6811858,rsl0516561,rsl7043445,rsl0516582,rs2352223, rs6842886,rsl0516630

Table 13 -10-

,rsl7672688,rs615837,rsl826424,rsl7008527,rsl0011584,rsl6993 87,rs6534760,rs35109 I,rsl0754209,rs931121,rsl7048163, rsl0519370, rslO519382, rsl7268257, rslO519586, rs7 89350, rsl429129,rsl356300,rs35695757,rs604863, rsl561492, rsl7621300, rslO517825,rs 17502674, rs35646569, rs9312521,rs6854438, rsl976544, rs6553613,rs4475089, rs7677592, rs9312246,rsl0520485,rsl7325360,rsl0520548,rs2310357,rsl4585 21,rsl0512779,rs4345 283,rs6701513,rsl60509,rsll8583,rsl0513058,rsl317209,rs30107 8,rsl358319,rs748418 ,rsl66576,rsl7311535,rsl402428,rs6871776,rsl2515056,rs255044 ,rsl6855989,rsl05209 36,rsl0520957,rs2047725,rs2331106,rs35147446,rsl0521023,rsl0 512682,rs6883840,rsl 0473348,rs6895107,rsl0512955,rs7719848,rs2032874,rs4865582,r sl6886256,rsl6886448 ,rsl0940535,rs2161500,rs602693,rs261252,rs2042945,rsl6897699 ,rs4354016,rs2662330 ,rs4844769,rs906351,rs949645,rsl7237618,rsl991483,rs324914,r sl60281,rsl70557,rs9 52840,rsl0067098,rsl534604,rsl2188167,rsl0514311,rsl0514343, rsl7083155,rs31465,r sl866390,rs6897349,rs2600825,rsl435199,rsl0515395,rs2416248, rs2114991,rsl560061, rsl7512333,rs6887868,rsl389935,rsl0519744,rsl7151248,rs22206 21,rs9327438,rs65408 02,rs791333,rsl0519977,rsl015565,rs667419,rs7730672,rs497644 5,rsl0515504,rsl8359 59,rs801168,rs456304,rs3866870,rsl7102658,rs6883434,rsl71054 02,rs2797257,rsl0495 017,rsl0796 _f rsl85323,rsl0515715,rsll45631,rsl363670,rsl516655,rsl7548653 ,rs21101 3,rs6870265,rs300208,rsl0043471,rs6885819,rsl422932,rs931339 6,rs6859754,rs315788 , rs 1902791, rs2546724 ,rs 9313699, rs4634972, rs 1826864, rsl0484693, rs 9328099, rs207304 2,rs9328348,rsl909099,rsl97119,rsl410364,rsl625084,rsl572002 ,rsl0485363,rs471203 7,rs4715888,rs4712277,rs6938496,rsl6884481,rsl291401,rsll759 720,rs2893857,rs2393 915,rsl015811,rs2248459,rsl3375635,rsl224499,rsl0495163,rsl6 891597,rs2894484,rs6 458445,rsl048077,rsl372567,rsl2200492,rs7773311,rs2505283,rs l7813135,rsl266912,r S659446,rsl884286,rsl7684802,rsl0455569,rsl2211518,rsl754454 6,rsl010326,rsl25267 35, rs3857464, rs4132147, rs2164166, rs34138673, rslO799319, rsl6874311, rs9444163, rs75 0426, rsl0485328, rs589818, rsl6871208,rs2313007,rsl7757989, rs3922556,rsl355023,rs3 804338, rs9320240,rs2297857, rs4483016, rslO484296, rs980214,rs686708, rs9320609,rs27 98326, rs7755529,rs9321028,rsl0485336, rs2274997, rs3798251, rs2446213, rs4085406, rs 9 285480, rsl0484798, rs853022,rs2698741,rs2328092,rs6901618,rs6935462, rs9390251,rs7 19787,rs2065147,rs3798573,rsl7084243,rsl7085108,rs335368,rs2 181069,rs6920842,rs9 364522, rs6901166,rs9295125,rs747866,rsl893537, rsl548307, rsl021563,rs2749258, rslO 499317, rs6463554, rsl7800524,rsl505310,rsl7342403, rsll767212, rsl7432356, rs4721888 ,rs7788251,rs2069837,rs488618,rs6462006,rs917275,rs6956143,r s7778110,rs6957997,r s4723696,rslll3117,rs6948900,rslll5715,rs4141152,rsl7208350, rsl525647,rs2270628, rs727051,rs801145,rsl032428,rs763317,rs2123597,rsl476866,rsl 342076,rs485865,rsl7 439220,rsl0495439,rsl0486822,rs978326,rs2052917,rsl523626,rs l0267099,rsl688886,r slO487091, rsl7163782 ,rsl527676, rsl488515, rs7798509, rslO269471, rsl539100, rs380802 3,rs849376,rs711492,rsl0499999,rsl0267033,rs2074116,rs224890 6,rs2402007,rsl75456 44,rsl7549557,rs20598,rsl534528,rsl916876,rsl404897,rs728600 ,rsl419508,rsl204516 ,rsl0487475,rs2012919,rs2029249,rs9640866,rsl0488340,rsl3459 38,rs3778689,rsl2859 33,rsl011672,rsl525108,rs6965390,rsl635884,rsl0247371,rsl406 718,rs2888408,rs2189 883,rs2040920,rsl524984,rs2701903,rsl0503170,rsl0103675,rs29 45886,rs2948587,rsl0 503390, rs6983332,rs35393495, rsl0503614,rsl492286, rsl871662, rs870215,rsl064960, rs 4570167, rs988031,rs4129581, rs7816405, rsl0504048, rs6473055, rsl0504114, rs213628,rs 6988606, rs7844299, rsl6921659, rsl 6922400, rslO5O4203, rsl567234 , rsl0504250, rslO4122 6,rs9298077,rsl7291458,rs7823840,rs831741,rsl7721390,rsl0504 525,rs830491,rs26263 49,rsl7446712,rs4623795,rsl0087223,rsl0504687,rsl7440838,rsl 0504790,rs711047,rsl 2604,rs395964,rsl3439583,rsl0504839,rsl0096362,rs2449539,rsl 7283482,rs2513858,rs 676654, rs720406, rs3808456, rs7823569, rsl346811, rsl0110735, rsl441028, rsl 6906528 , rs 16910507, rs2082801,rs2294119, rsl 6921797, rsl317548, rs3912096,rs4741815, rslO491731 ,rs2493766, rs7850299, rs2184400, rs9298651, rs7863023, rslO491758, rslOδ 10105, rs30087 46,rsl944744,rsl0123624,rs4579612,rsl857652,rs2015345,rs7866 540,rsl0511731,rs929 8876, rslO511791, rsl0511804,rsl414025, rsl 999368, rsl442288, rslO781101, rsl7060535,r sl0904952,rsl0125560,rsl7788791,rsl7427625,rs2378554,rs27881 10,rsl323763,rslll40 664,rs2771102,rs2153058,rs9409765,rsl608973,rsl556858,rs9886 92,rsl916676,rs92993 83,rs885954,rs6477581,rs7029094,rsl327785,rsll999319,rsl0980 495,rsl0513249,rsl45 0194, rs6478298, rs961959, rsl6824230,rs2239656,rsl0739594,rs2315078,rs2119242,rsl7

Table 13 -11-

51916, rs731533,rs2173202,rs7074731, rsl6925580,rs2437392, rs7922685, rsl417569, rsl6 1259,rs687812,rs2598573,rsl767523,rs2252432,rsll010908,rs247 4876,rs4660606,rs710 218,rs7536253,rs2505526,rsl999270,rs568089,rs912803,rs218023 4,rsl492708,rsl08651 4, rs7068119,rs2592892, rs2889611, rs2104212,rs6680807,rs951366,rs4935712, rs6704354 ,rs6684472,rs9500,rsll94668,rs4409640,rs6429299,rs7549388,rs 6587475,rs4880919,rs 722828 ,rs7923404, rs2807763, rs7903120, rs7907212, rs2256703, rs2573367, rsl 6913959, rs 2274312, rs7918536, rs303199, rs2418929, rsll005987, rsl573252, rsl6912196, rs2489001, r s4917504, rs2393555,rs3862129,rs7906271,rs2016844, rs3999089,rs2068327,rs7928523, r s4373909,rsl915624,rs2359232,rsl0509273,rs932656,rs652541,rs l599711,rs659551,rs7 13024 l,rs2951774,rslO762505, rs7306423,rs2688608,rs7078351,rs7097617, rsl317275,rs 727948, rslO490996, rs6480902, rs2373011,rs3829300,rs7299227,rsl716167, rs3851061,rs

7992848,rsl7712988,rs883805,rs2177830,rsl556549,rs2036130 ,rsl514461,rsl764773,rs 4390461,rs4417464,rs2882684,rs7091402,rs8011152,rs8006512,rs 6575209,rs7154252,rs 721637,rs2096177,rs735480,rs726110,rsl342791,rs7165637,rs933 807,rsl7112076,rsl71 12250, rs4778893, rslll2707,rs987793, rs6496603, rs552644, rs916947, rs4545838, rsl6418 79,rsl0509755,rs6497456,rs2281879,rs7500931,rs6499658,rs4561 463,rsl7117517,rs,649 8837, rs7203452, rs7894243, rs4790618, rs4254373, rsl591815, rs8079280, rs6607337, rs347 70106, rs4793952, rs4619440, rsl0509922, rs438163, rs7072709, rsl0509959, rs8086751, rs7 917983,rs7233417,rs7090904,rs7244171,rs8098930,rs4807852,rs8 103099,rs6511842,rs4 926188, rs8113628,rs2420673,rsl343703,rsll26973, rs4670034, rs6691598,rs 6720704, rs4 577244,rs2901363,rsl474016,rs4443040,rs2264599,rs6546192,rs7 607375,rsl0510149,rs 6713986, rs4853434,rs6726401, rs4972036, rs4629164, rsl0493093, rs2971899, rs2995307,r s4853606,rs7584910,rs4619602,rs6431428,rs6136898,rsl2294758, rs6085074,rs6071887, rs4812833,rs6018635,rs6125931,rs6070149,rsl857853,rs8133274, rs462295,rs8127664,r s9967,rs622654,rs2585753,rsl440968,rsl984870,rs6442055,rs678 7449,rsl2363488,rs38

86343,rsl2791150,rs4599321,rs6807414,rs7431389,rs7629753, rs4146786,rs6438473,rs7 938462,rs2811416,rs7374120,rs715190,rsl2280865,rs951776,rs76 22423,rs4894709,rs72 4273,rs2669961,rs7646074,rs685428,rs6825281,rs6817108,rs4246 697,rs6449146,rs4642 249, rs6820719, rs34398124, rs4234981, rs2711935, rs4306983, rs4073847, rs7688534, rslO7 68226, rs6827698, rs4337734, rsl7589032, rsl7361887,rs4266344, rs7697360, rs7675389, rs 4596255, rs4345839, rs2310956,rs4132091, rs4696443, rs2861921, rs4501178, rs4146926, rs 6818921, rs4863076, rs4129601, rs2913353, rsl2364347, rs835153,rsl0501321,rsl0501329, rs2089575,rs326071,rs7713523,rs4995095, rs6596651,rs6594805, rsl 1605053, rs4479881, rs2909760,rsl422821,rs2434411,rsl7185574,rs6920352,rs2071036 ,rs2744237,rsl49946, rs7760860,rs308351,rs2457179,rs5002649,rs2812683,rsl7162064, rs7760243,rsl0501412 ,rs6930773,rs3901607, rs4382297, rsl945247, rsl7137751, rs567236,rs4244636, rsl560617 ,rs3789586, rs2938485, rsl 939595, rs3801562,rs4729950, rsl945826, rs40898, rs4288303,r s37644,rs6466588,rsl943714,rs2428776,rsl638196,rs7802599,rs2 312035,rs2952131,rs7 840494, rs4732757, rs6472088,rs499195, rs2595606,rs2513363,rs6469053, rs442355, rs246 8147,rs2211417,rs2056247,rs7015414,rs4339605,rs6471156,rs449 5466,rs7828303,rs787 3062, rs6475653,rs7873601,rsl0501889, rs2938882,rs4877521, rs7019633,rs2296812, rs78 55317, rs3012584,rsl2043385, rs4255200,rs7045079, rs569575,rsl0501999,rs2701968, rsl 545860, rsl0502061,rs754562, rs2847443, rs7410107, rs410757, rs989938, rs396981,rs2823 017,rs2823120,rs2823206,rsl736010,rs7279770,rs2823556,rs2823 806,rs7364073,rs2824 318,rs2824376,rsl029249,rsl491780,rsl051530,rs2825019,rsl770 2418,rs2825233,rs651 7864, rs2825897, rs2825998, rs2826239, rs2726924, rs460639, rs761341, rs9983588, rs72821 15,rsl556311,rs232516,rsl7003996,rs2827295,rs9306082,rsl8990 0,rsl984333,rs200710 ,rsl557377,rs2828470,rsl910623,rs2829205,rsl7000893,rs926962 ,rs2829955,rs9305274 ,rs2830048, rs2409168, rs4817119, rsl444268, rsl 676553, rs4583006, rs2830839,rs2831138 ,rs2831270,rs687607,rs2831677,rs9983789,rs2831839,rs9305386, rs2832208,rs2832308, rs2832417, rs456784, rs2243535, rs2832661, rs2832810,rs2832907,rs2833017,rsl783006,r s9977656, rs2211787,rs2254132, rs2833801,rs2834024,rs8132255, rs7282496, rs2834238,r s2247884,rs8128036, rs762164, rs7281056,rs2835143,rs7280598,rs2835382,rs743428, rs2 835530, rsl009922,rs2211847,rs2836285,rs2836524,rs2836870,rs7275773, rs571227,rs28 37132,rsl6998749,rsl6999365,rs2222979,rs2837974,rs3017438,rs 220157,rs6586261,rs7 936,rs9982929,rs762395,rs8134178,rs2006288,rs452002,rs963716 6,rs2838833,rs215044 7,rsl556329,rs7282658,rs2839008,rs2839117,rsl0502194,rs75343 76,rs3829261,rsl2233

Table 13 -12-

216,rs2963995,rsl0209375,rs9401713,rs7030204,rs6989204,rs 3743299,rs8106293,rs486 3332 ,rs3862614, rs2292029, rs7569357, rs7707792, rsl2239009, rsl3010269, rs7228463, rs4 686917, rs7088535,rs6861627, rs2343614, rsll 679258, rs9669600,rs798121,rsll083616,rs 969166,rs843509,rsll64768,rs555206,rsl060451,rs6771377,rsll0 05290,rsl550816,rsl7 038082, rs4952209, rsl350966,rs367830,rsl7258247, rsll933380,rs607099,rsl7111116,rs 6780461, rs7643528, rsl7148570, rsll97312,rs2982507, rs976980, rsl7047725,rs6919506,r Sll778179,rs2370671,rsl0956153,rs4741946,rs2036715,rs7153434 ,rs9585502,rs7671283 ,rs7444761, rs9360509,rs4731117, rsl7102685,rs2719277, rsl896151,rsl7378638, rsl9066 48,rs6938995,rsl7548303,rsl954147,rs4690915,rs6946184,rsl683 4635,rs9289896,rs688 7937,rsl2574346,rsl2581828,rs2197742,rs2225239,rsl0800571,rs l473722,rs4328542,rs 12698891, rs3760193, rs2189525, rs7682354, rs2868877, rsl 6995923, rsl780671, rs7604110, rsl7642621, rsl6975893, rs682842,rsl7082884,rs477574, rs2646107, rs6758402,rs6786582 ,rs343135, rsl7790961, rs7000924,rs9292086, rsl633550,rs9362810,rsl0493206, rsl67715 6,rsl0864148,rsl6866258,rsl7833139,rsl7352886,rs2219471,rs22 24082,rsll210726,rsl 1208170,rsl2642926,rs9858096,rsl571346,rs6869801,rsl6958589, rs7033404,rs4886012, rs5018958 ,rsl790970, rsl 1782284, rs7527084,rs674045, rsl995392,rsl0795504, rsl049196 6, rs6666075,rs7133350,rsl0913081,rs343114, rs279223, rs2176056, rs9370510,rsl050540 ,rs6552295,rs9667649,rsl797081,rs250856,rsl005676,rsl7807624 ,rsl0875381,rs528366 ,rsl0841371,rs7091938,rs6766612,rsl2234842,rsl65860,rs205833 2,rs3131379,rs782614 2,rsl0402279,rsl511315,rs494921,rsl006669,rsl7723822,rsl0862 940,rsll627509,rs799 5153, rs613966,rsll063791,rs9883302,rs696874,rsll969346, rs 6849330, rs4800675, rs237 5480, rs2493277, rs434609, rs2660917, rs4233337,rs2490272, rs9321715,rs4728962, rslO81 2663,rs6544416,rs2874688,rsll056433,rs6038399,rs2184267,rs26 10997,rs2049105,rsl2 536742,rsl287505,rsl2477902,rs2129093,rs6810376,rs6786319,rs 2114851,rs9684647,rs 1520311,rsl0794629,rsl7277717,rs4119152,rsl0748986,rs4894829 ,rs2456251,rs7689,rs 11750131, rs4756258,rs324119, rs9565452, rsl 6930665, rs9840905, rs470089,rs2742982, rs 4083443,rs4419372,rsll064896,rs808687,rs4483354,rs872204,rsl l715746,rsl29423,rsl 3070320, rs2380598,rsl7120564, rs2241090, rs2954695, rs4557960, rs3751264,rs2913993,r s3818343,rs7843027,rs526952,rs3915499,rs2960578,rs7574968,rs 297325,rs742452,rs79 30322, rs 6440953, rsl7038014, rs 9383023, rsl 1053625, rs842226, rs7713770,rsl2191720, rs 8096972, rsl7714537, rsl7107654, rs830062,rsl2024134, rs4077273, rsl859120,rsl20963,r S13114718, rs6091633, rsl7096742,rs2197673, rs4558823, rs887806,rs2866852, rslll62190 ,rs9566215,rs4768924, rs4877510, rs7527185,rs860324, rsl806771,rs7485419, rs7135655, rs2148135,rs3744307,rs7947237,rsl7367409,rs4771572,rsl695570 5,rs7585448,rs764374 9, rsll209782, rsll 934054, rs462891, rsl2532970, rs4596499, rs3825270,rs2389972,rsl503 024, rs7761777, rs2299030,rs5003528,rs311362,rs9834824, rs48184 I,rs9648572, rs461159 0,rs2282302,rs4814027, rsl669925,rs6896258, rs9467520, rsl483309, rsl0280353,rsl8909 12, rs6821333,rs6468304, rs953994,rs7046257, rs4620305, rsll615548, rsl0017809, rsl 172 3592, rs7620017, rs2779708, rsll065663,rs9549059, rsl6852418, rsllO7312,rsll244393, rs 1554074, rsl3396831,rsl502909,rsl2729389, rs2929111,rs2651314 ,rs8092765, rslll49298 ,rs9635564,rs2309824,rsl0989904,rsl2624267,rs9878562,rs68054 29,rs3798979,rsl7187 851,rsl7688430,rsl018119,rs7243667,rs7310076,rsl0477917,rsl4 88083,rs7592587,rs39 48710,rsl0744146,rs9300286,rs7894459,rs9456734,rs4457905,rs3 013685,rs3922840,rs9 519052, rslO410650, rs2165280,rs4918029, rs7909447, rs6511286,rsl349244, rslll71732,r sll954658, rs2671711, rs7620047, rs4757001, rs1470034, rs10180840, rsl1258991, rsl61623 4,rslll00102,rs969235,rs2064187,rs2048901,rsl517949,rs469328 3,rsl7135109,rsl3026 780, rslllO4990, rs4684717, rsl0233082, rs7321742, rs6498653, rsl701877, rsl539835, rslO 109799, rs4635707, rs2303658, rsl7098856, rs6081190, rs8189140, rs9545075, rs5751930, rs 11096511,rs3135998,rsl0776614,rs856554,rs6904333,rs7500444,r s2816097,rsl276444,r sl0209491,rsl0875142,rs870582,rs4848104,rsl6871765,rsll72955 6,rs4889989,rsl01238 10, rs433351,rsl6933980,rsl0761288, rs2159864, rsl553316,rsl2653355, rsl 6984293, rs22 38692, rsl7488764,rs4690627, rs6924108, rsl7112398, rslOl 66327, rs6439552, rs4689558, r sl2291567,rs4302188, rs4799767, rs6487305, rs2737339, rs7144288, rs4958549, rs3112916, rs3782323,rs767925, rsl7042035,rs790383, rs376638, rsl7059879,rsl6864614, rsll956061 ,rsl0910746,rsl7310011,rs7596337,rs2023631,rsl939995,rsll264 041,rs4812368,rs4305 894,rs2566759,rs6825603,rs7716817,rsl7797971,rsl2380087,rs47 19072,rsl512763,rs21 11326,rsl997635,rsl0267496,rsl7120765,rs990060,rs6477556,rs4 624393,rsl555741,rs2

Table 13 -13-

175567, rs8140357, rsl975980, rsl7490696, rs593099,rs4905949, rs2000244, rsl7517794, rs 4558788,rs3181,rs7499978,rsll054942,rs7618924,rs500795,rsl32 0780,rs9490149,rsl92 5369, rs9553075,rs6890123, rs7201008,rsl0880190,rsl363311,rsl0505968,rsl554393,rs2 213760,rs6765971,rs502442,rs6791291,rs7199198,rs842775,rs910 622,rsl0873113,rsl02 76168,rsl0823717,rsll593974,rs546333,rs6999692,rsl2544305,rs 7470,rsll687163,rs73 03819, rsl6990309,rsl364568 ,rslO424620, rs4709988, rsl7821231, rs2136834,rs7240607, r s6536287,rs7529144,rsl7037141,rsl819863,rsl7275333,rs7954736 ,rs7908733,rsl005241 8,rs9593041,rs9878474,rsl0929811,rs6501691,rs6535205,rsl2193 548,rs7516564,rsl083 0562, rsl0062069,rs9856772,rs6050266,rs9885194,rs6537156,rs7860538 , rs2721788,rs26 05050, rsl7310558,rsl0942278,rsl7712043, rslO864034, rsl532335,rs4480236, rs7630933, rslO849045, rslO889634, rs2355459, rs4386198, rs26050, rs7962172, rsl0790914 , rsl540912 ,rs6059827,rs224825,rsl2478156, rs300119, rsl2982082, rs4843946, rsl7269905, rs233379 ,rs395936,rs9969813,rsl923313,rsl0165154,rs7634548,rs906482, rsl0185213,rsl270847 0,rs247547,rsl6886744,rsl3108896,rsl7081109,rsll739734,rsl77 18348,rsl7024410,rs7 581178, rslO46889, rsl7727339,rsl547584,rs7686874, rsl0936969,rs2256332,rsl7355116, rs6467596, rsl6946677, rsl6906661,rs7802537, rs2126967, rsl2438497, rsl420996,rs68475 98, rsl575891, rs3769524,rsl465445, rsl 6837811, rs6849369, rsl6895027,rs6766386, rsll7 18762,rs9650197,rsl229459,rsl6973180,rsl2661091,rsl0217547,r sl6852350,rsl0888504 ,rs3736861,rsll660879,rs6879078, rs4128904, rs430208, rsl7031777,rs4378909, rs749164 ,rs4751723,rsl52951,rs2513294,rsll660007,rs6666581,rs9381477 ,rs9876243,rs2720671 ,rs2764236, rsl0038868, rsl688565, rs2866218, rsll57755, rsl577636, rsl7012393, rslllδl 090, rs325160,rs9845005, rsl7785550, rs741194, rs594771, rs931671, rsl2914315, rsl68311 9,rs2550725,rs9486619,rs982295,rs3779995,rsl7076276,rsl09139 85,rs6063438,rsl7615 186, rs4394651, rsll052835,rs4902033, rsll 625777, rs797078,rs2328165, rsll 659919, rslO 150592,rs830238,rs346591,rs4140738,rsl0406668,rsll068860,rs7 032947,rsl2467407,rs 10440835,rs9389215,rs205946,rs4943797,rs7136330,rs2505349,rs 7825706,rsl0821727,r sl2542004,rsl0188007,rs9889607, rsll748542, rsl0821570,rs262521,rs7617480, rs 699151 3,rs2653761,rsl2416804,rsl0197121,rsl458223,rs3263,rsl736418 9,rs864625,rs6972794 ,rsll234564,rs786990,rs3844608,rsl481785,rsll50914,rsl050613 8,rsl6907228,rsl4321 33,rs2383957,rs7534785,rsl7804971,rsll67537,rs2961986,rsl045 9262,rs2118355,rsl08 77590,rs538939,rs9291428,rsl857943,rs2413752,rs25856,rsl7159 483,rsl2231265,rs473 3963, rsl3229259,rs280013,rs592070,rs2256295,rs4862810, rsl952974, rsl549905, rslO97 6048, rsl0155049, rsll646268, rs936589,rsl497203, rsl0120587,rs2491393, rs8123772,rs9 332410,rsl7168987,rsll075345,rsll60749,rs268459,rs7582831,rs ll486906,rsl7154234, rsl0201518,rs 6770677, rs9669403,rsl2713159,rs7154992, rsl7146687, rs7707416, rs30652 6,rsl6940067,rsll026144,rs2840959,rsl7192317,rs3127194,rsl20 55010,rs346644,rs712 9651, rsl2639369,rsll988657, rslll83567,rsl0995153,rsl7167044, rs9916782, rs876970, r s9549365, rsl433233, rsl7331933,rs6691362,rs7805748, rsll67083,rs4693437, rs9544250, rsl579244,rs7032444,rs9538719,rs4507353,rs834234,rs277203,rs l0162149,rs606667,rs 4904512, rsl6974735,rs4329129, rsl791879, rsl2212324,rs667857, rsl 1941314, rs672098,r sl410408, rsl896270, rsl7619763, rsl2125867, rs2971817, rsl7167173, rsl2100975,rsl0125 441,rsl6862933,rsl2578426,rsl7033265,rsl7050678,rsl342638,rs l6916914,rs9316245,r s479531,rs711437,rs230800,rsl7096738,rs2879855,rsl357741,rs4 542192,rsl2669859,rs 7909942,rsl0983772,rs4076649,rsll647815,rsl2907922,rsll89447 4,rs6534816,rs463064 ,rsl7717495,rs4964761,rs6760197,rs8036863,rsl564131,rsl04027 8,rsl0918917,rsl4578 93, rsl7133608,rsl6840748, rs4717258, rsl 936297, rsl2509660,rsl7706797, rs7813614, rsl 0506281, rs4835994, rs8079095, rsl2154111, rs4429339, rs833829,rs858267,rsll985168, rs 1994744,rs6588429,rs270285,rs9655844,rsl0969132,rs7740296,rs 9326173,rs7148442,rs 10864552, rslO401153, rs4391753, rs6806811,rs753064,rsl7099052,rs2804672, rs4692266, rs2816705,rsl2889894,rsl7500476,rsl2432063,rs764742,rs645383 ,rsl979517,rsl691046 3,rs7752050,rs518217,rslll67121,rs2246462,rsl6895171,rsl0912 505,rsl0954940,rs808 7237, rsl2632781,rs4980024, rsl783953,rs9574041,rs7636734, rsl393114,rsl7135753, rsl 1790501,rsl0836028,rsl6830289,rsl0754006,rs3907374,rs6476491 ,rsl60448,rslll86960 ,rs9592536,rs590197, rs7305856,rs7157412, rsl7086994, rs4938871,rs2888440, rs7307637 ,rs2181420,rslll26378,rs956459,rsl3007279,rs41632,rs7975189, rsl0953644,rsl710598 5,rsl983193,rsl2711736,rsl3227751,rsl0464520,rsl0506328,rs67 97926,rsl6946292,rs3 026550, rs4698634, rs534214 , rs7260181, rs778403, rsl6956753, rs6734099, rs8030359, rsll

Table 13 -14-

139465, rs3900792,rs2612015,rsl2130292, rsl0829062,rsl965276,rs6052830,rs7782625,r _S 2065945,rs4945035,rsl462720,rsl0277539,rs6557618,rs824343,rs l0256270,rs619824,r sl2340895,rs2905880,rsll041427,rs7106625,rsl0145148,rs238374 7,rsll77279,rsl38483 l,rs2291075,rsl389790,rsl7639286,rsl0779560,rs3739216,rsl368 048,rsl874528,rs4130 266,rs4913499,rs338586,rs8107919,rsl468489,rs4956450,rsll848 514,rsl2474886,rsl64 3887, rs6668320,rs7863882, rsll 668329, rs4965044, rs2011594 , rs709545, rsl7106657, rsl7 346822, rsl2308086, rsl025920,rsl0257095,rs7954123, rs7677027,rs4340915, rs8062405,r s9958001,rs2866688, rsl828520,rs795440, rs276070,rsl0873634,rs2757528,rs2313723,rs 17056439, rsll 606785, rsl7048768, rsl0868909,rslll05686,rs714213, rs600964,rs888931, rs9513922,rsl7682012, rsl0033601,rs787695, rslO196438, rs2892914,rsl0783957,rsl7073 665,rs4754136,rsll730408,rs9353327,rsl212595,rs7014456,rs964 4193,rs7646711,rs370 58,rsl2338044,rs3914648,rs7027204,rsl0823485,rsll618347,rs99 59163,rs34219,rsll69 1603, rs6884993, rsl0270250,rs567591,rsl2959322,rsl712704,rs6959224,rs9372987 ,rs96 42843, rs4796808, rs6090988, rs2271979, rsl3018813, rs802684 , rs2241825, rs9572034 , rs72 58387,rs8072250,rsl384424,rs4956306,rs6903596,rs7572149,rs69 15445,rs4440293,rsl0 834699, rs7967479, rs4657943, rs6448778, rs4556017, rs243284, rs765031, rs922358, rslOOl 9381, rs954568, rs4906395, rsl2475063, rsl521875,rsl3423597,rslll58762,rs4633642, rsl 6853820, rslO896615, rs968323, rslll50195, rs3008131, rs2329049, rs6493186, rs 6703127, r s273612,rs4678493, rs9513199,rsl7107396, rsl480468, rs6682219,rs7094316, rs 6681719, r sll759010,rs6076501,rs7113769,rs2098291,rs7765849,rsl2709748 ,rs2997128,rslll2603 4,rs4360333,rs4649343,rsl0977509,rsl245361,rs2595146,rs29810 88,rsl0048187,rsl078 4555, rsl7153606,rsl3010437,rs8098366,rsl2076854 ,rs422140,rsl954600, rsl022359,rs7 677996, rsl2886295, rsll989145, rsl0858287, rsl379221, rs3822410, rs811502, rs7096909, r Sll612383,rs7649108,rsl2319024,rs7650473,rsl405879,rsll65551 2,rsl0832405,rsl3770 65,rsl7052156,rs7806473,rsl0460854,rs4747358,rsl386476,rs931 7658,rs7845057,rsl32 20004,rs9301957,rs4942712,rsl399162,rsl0929912,rs6119407,rsl 7752225,rs7636464,rs 16907587,rsl2714026,rsl7077963,rs3847449,rsl7268589,rsl23181 56,rsl944090,rs70203 2,rs9820583,rslll97525,rs7184034,rsl0966674,rs6452580,rsl323 7702,rsl2423987,rs79 52818, rsl724728,rs4539561, rs5997579,rsl699002,rsl2939695,rs2299231,rsl464919, rsl 1933944, rsl3126941,rs7927868, rsl7283290,rs3804619, rs7327107,rs2404851, rsl557217, rs7031729,rs2054855,rsll738840,rs747502,rs2278617,rsl2499470 ,rs7590431,rsl311757 l,rs5909,rs2850575,rsl2244405,rsl0832554,rs4463297,rs6994957 ,rslll97666,rsl84478 ,rs7147148, rs7640614, rsll621118,rs7148755, rsl0506621,rsl0750388,rs847138, rslO917 851,rs2820046,rs6574343,rs32662,rs4694196,rsl3358325,rs31243 15,rs4633669,rs25446 l,rs4726774,rs6846367,rs2145900,rsl386485,rsl2267435,rsl0902 849,rsll790408,rsl20 4772,rsl0199504,rs7178283,rs243267,rs8016345,rs964040,rsll24 4438,rs268588,rsl073 9219,rs7220733,rs979537,rs924465,rs6916312,rsl3185812,rs3098 511,rsl0815714,rsl08 79278, rs3911267,rs4634890, rsl495273, rs596252,rsll022699,rsl2657551, rs6709175,rs2 430522, rsl7113010,rsl2900970,rs7994283, rslO947096, rsl7046124, rsll574851, rs612891 8,rsl7237977,rsl0931753,rsl2872448,rs6837315,rs2848793,rsl48 7036,rs2461991,rs357 552,rsl0873529,rsl7625594,rs4924052,rs2515616,rsl515022,rs38 67133,rs394850,rsl20 87046, rs7742010,rsl7410903, rsl2191885,rs7136574, rs2139710, rsl7464903, rsl2257119, rs7906591,rsl321162,rs2146333, rslO863644, rs676318 I,rsll758543, rs2618735,rs205080 2,rs4791079,rsl0219275,rs6977125,rsl2120304,rs843652,rs76931 99,rs970833,rsl26682 89,rs7135414,rs7663176,rs2174440,rs2707778,rs2286553,rs20446 81,rs807525,rs678653 0,rs7723699,rsl7564783,rs4696018,rsl3188408,rs6600949,rsl763 279,rsll211946,rsl01 42167, rs2480756, rs4907918, rsl0736996,rs4662765, rs2335847,rs8055398,rsl36687,rs46 92589,rs6006179,rs564285,rsl0506771,rsl2334387,rsll244942,rs 7405124,rsl021878,rs 11144794,rs589629,rsl0779468,rs883105,rs8025854,rsl0000200,r s6589579,rs9929840,r s6924682, rsl52837,rsl0901364,rs2391735,rs921705,rsl0468219, rsl0506806,rs2359677, rs6592416,rsl7158996,rs2451819,rsl82148,rsl0506820,rsl603785 ,rs7182280,rs6513812 ,rsl0077641, rsl7227288, rsl7006927, rs4663629, rs9484152, rs2871873, rs2761357, rs4574 616,rs2091013,rs285642,rs9527779,rsll216521,rs6590673,rsl085 0417,rsl338167,rs434 3365,^1187328,^179456,^9902949^310790230,^11763512,^1123511^ 317040095^31 2829851,rs3178615,rs4143188,rs2865408,rsl2138917,rs975809,rs l519943,rs7580494,rs 4760449, rsll240992, rsl7155168,rs4270661, rs6695006,rsl6856247,rs34816265, rs779474 5, rs9373174,rs2119014,rs7894018, rs773625,rsl0010535,rs4552921, rs4233387, rsl 69399

Table 13 -15-

83,rs7217422 _f rsl0439141,rs7515512,rs4793433,rsl2262419,rsl861500,rs816943 ,rs3864 157, rs4875584, rs9507098, rs6136525, rs3746670, rs4906120, rsl350804 , rsl077009, rsl081 964 I,rsl6963746, rsl466382, rsl7033473, rs6955464, rs7512525,rs2617815, rslO988111,rs 10829890,rs7230919,rs4246989,rs2281173,rsl7369640,rsl493417, rs7464824,rsl7005594 ,rs7427, rs7825068,rs4643103, rs6489811, rs2405421,rsl3221321,rsl0024436, rsllO45611 ,rs2066575,rs9381033,rsl2252023,rs4937700,rs2661474,rs472748 0,rsll608255,rsl7040 439,rs7978094,rsl0134110,rsl6951395,rs9360980,rs2602036,rs72 24754,rs2187132,rs80 72363, rs7004177, rs2001817,rs7132569,rs4073220, rslO752168, rsll54330,rs7616573, rs9 08279,rsl7083753,rs4134138,rs217367,rsll617259,rsl983374,rsl 7212430,rsl998746,rs 1818894,rs9291586,rsl7712228,rsl2141717,rsl7155405,rsl556642 ,rs7257235,rs3911131 ,rs932784,rsl7580874,rsl0201588,rs3924499,rs4274812,rs340694 71,rsl027690,rs37912 99, rsll780628,rs2697575,rsl2987254,rsll806070,rs4842732, rs8083184,rsl0506994,rs6 06262, rs871512,rs7930465, rsll596481, rsl0001785,rs4973353, rsl2091311,rsl881235,rs 12593951, rsll635850,rsl080383,rs4670142, rsl7520514,rs2979790, rsl493779, rslO77915 9, rs7398603, rs2865707, rsllll7717,rsl7827840,rs7823924,rs6669690,rsl2791318, rs965 6041,rsl6854601,rsl0992025,rs2586038,rsl7752168,rs4973518,rs l3115147,rs2945466,r s818477, rs2323156,rsl 949954, rs7201437, rslO41310, rs541020, rsll007809,rs4962153, rs 10764859, rsll748424, rs4326830, rs2412033, rs7584604, rs9381416, rs2055141,rs4318894, rs2648446,rs753948,rs730561,rs822874 _f rs7503377,rsl6933060,rsl951804,rs9922431,rs 6669433, rslll41878, rs7534757, rs4749523, rs9828187,rs4867557, rs216009,rsl949681, rs 10899084, rs2415543, rsl6862423, rs4901985, rs7941538, rslll69634,rs4974486, rsl261701 9, rs3892714,rs8011590,rs4612577, rs508192, rs7739088, rs314276, rsl0028496, rs349662, rsll670672,rsl0119132,rslll33439,rs2625289, rs8136328,rs7910631, rs2305573,rsl9677 07,rsll873058,rsl0788396,rs2305737,rsl6972668,rs4234692,rsl0 109855,rsl468983,rs7 785899, rs4724420, rs9968356,rsl6890175, rsl601413, rsl609893, rsl2527811,rs7486084,r Sl881889,rs8041059,rs6803675,rsl7301525,rs4764099,rsl7137135 ,rsl6902186,rs201554 I,rsl7267554,rs8017720,rslll 66018, rs8113309,rsl3325182,rs6837313,rs7533329,rsl 17 26343, rs3908571,rs238824,rs4544772, rs6443991, rs7017801,rsl0419469, rslll59988,rs6 671295, rs4670016, rs2225173,rsl0186594,rsl2464911, rs9933102,rsl7753961,rs7459622, rsl426622,rslll97887,rsl7232841,rsl6959825,rsl983546, rsl 6950911, rsl2723288, rslOl 1778 ,rs514743,rsl6873865, rslO746204, rsl7812169, rs6602868, rs7807750, rs4852184, rsl 7120487,rsl6864008,rs599044,rsl015695,rs289227,rs7104110,rs6 736714,rsl6861857,rs 6802276, rs6668429,rsl866161, rs9804742, rs7202799, rsl7538964,rsl0960309, rsl 6828505 ,rs855288,rsl545951,rs9375864,rsl0457470,rsl7542122,rs793843 3,rs6572793,rsl25432 93,rsl2449687,rsll210220,rs8002415,rsl387667,rs673676,rsl281 3302,rs7232350,rslll 37052, rsl0738885,rs4669613, rs9963828,rs806491, rs8095885,rs7906697, rs3884639, rsl 9 20146, rsl2505778,rs931801,rsl7781142, rs6021953,rsl7117900,rs424970, rsl7123002, rs 10004822,rsl7775174,rsl0956823,rs7747166,rs4657971,rs6476445 ,rsl0877173,rs796302 2,rslll74126,rs4527833,rsl2643201,rsl7804933,rs4774891,rsl53 0495,rslll72950,rsl0 099531,rsl548305,rsl0052968,rs9937520,rs9310449,rs8010024,rs l0783342,rs2370919,r sll973964,rs383402,rs590282,rs6539984,rs491895,rsl474356,rs5 753966,rs271353,rs79 72152,rsl2513298,rs2770777,rs692097,rs7635777,rs2633405,rs75 96606,rsl858410,rs37 79585,rslll44406,rsl7445972,rs2239728,rs2997114,rs2358650,rs 4081670,rs7592520,rs 6857264, rs34050852, rs2131731, rsl 1151159, rs7130321, rsl0055080,rs3863942, rs7709726 ,rs7950287, rs3734145, rs633832, rsl7049573, rsl 6847040, rsl2308347, rs702097, rsl01032 25,rs7198145,rsl7615148,rs7254837,rsl0215153,rs4275659,rs692 9357,rs2685297,rs240 380, rs2241220, rs7713109,rsl2738173,rsl2467730, rs7843337, rsll971702,rs3003975, rsl 0921219, rs2282092, rsl 1173732, rs4496923, rs664356, rs7565620,rs779398, rs3218203,rs4 789892, rs2375636,rsl0823691,rs2151065,rs6687835,rs7325638,rs7790906 ,rs2426703, rs 6983033, rs4569490, rs2292303,rsl3271095,rsl0883857,rsl0778450, rsl234256,rs385039, rs7559906,rsll223585,rs7926523,rsl3222524,rsl7278473,rslll34 141,rs6540263,rs7292 688, rs2820331,rs2806593,rs27975,rs2319144, rs4917360, rs7596691,rs302756,rs7529058 ,rsl2712602,rsl518056,rs2600737, rs6490034, rs2710293, rsl471407, rs7548272, rsδ 10023 9, rsl2469242, rsl2964004, rs4747755, rs2879160,rs7730767, rsl2419692, rs4703270, rs993 6750,rs4241357,rsl6846743,rsl0927348,rs6680026,rsl97911,rsll 097115,rsl2514766,rs 4416176,rsll570570,rs7448519,rsl0993768,rsl2671447,rs2242599 ,rs586749,rsl951342, rs7531491,rsl7446444,rs2867985,rsl0269665,rs6845524,rsl68572 99,rs7567643,rs27352

Table 13 -16-

08, rs9886561,rs7293623,rsl6946520, rs4426678, rs7774797,rs8119705,rs7806304,rsl516 311,rs9934407,rsl7132762,rs941068,rs6450211,rs2012937,rs4895 241,rsl2449441,rslll 22348, rslll32004,rsl037908, rs2380671,rs7653590, rsl941195, rs6121420,rs6981959, rs6 100708, rs39510,rsl3015655,rs6857474, rs2046058 ,rsl3289822, rs4419043, rs6556177, rsl 2612492, rsl517414, rs4954262, rs4303351, rsl417888, rs8181778,rs546288, rs2228133,rs4 714684, rsl2405120,rsl2833727,rs462429, rsl2587164,rsll074555, rsl542721,rs417591, r s2880056,rs2289529,rs4862588,rs6586191,rs2366385,rsl2076548, rsl464949,rsl2708919 ,rs2126314,rs6125553,rs6840678,rsl7541474,rs3754950,rsll6473 69,rs3734000,rsl2238 738, rsl841337, rsl482058 ,rs629168, rs6538901, rs7151091,rs2065055,rs6593732,rsl2607 152,rs2604270,rsl0441655,rs512523,rs4356771,rs7121214,rsll90 1495,rs744874,rsl087 6192,rs3735730,rsl7047236,rsl798891,rs6064389,rsll080075,rsl 787781,rs3866760,rs6 126702,rs6139832,rslll96923,rsl2120218,rs7645442,rs2553793,r sl2816489,rs9406109, rs9804386,rs565450,rs2132845,rs404566,rs9868686,rsl7482753,r sl2302490,rsl0965245 ,rsl6985368,rs7563678,rs2600057,rs7715047, rsll800779, rs4933555, rsl2325830,rs4661 222,rs4346962,rsl3321798,rs9377619,rs208814,rsl2482209,rs241 3748,rs329044,rs5998 623, rs7209900 _f rsl7222135,rsl0964127, rs3131785,rsll640870, rsll900637,rs7613454, rs 389475, rs7216955,rs9428107, rs746632, rs7221587,rsl7642699, rsll997874,rs3134904, rs 7513527,rs2875248,rsl6861615,rs733163, ^' rs901824,rsl7744902,rsll037267,rs4683766,r S16969866, rs903077,rsl010837,rsl404883, rs442170, rs221770,rs571888,rs 6532482, rs93 94550, rs4147419, rslO888466, rs7656114, rsllll5417, rsl7169254, rs8004481, rs2737706,r s2761680, rsl2619033,rs7928967, rs6054514, rs2738710,rsl2025814,rs4993301, rsl770023 5,rs900828,rsl025910,rsl2664006,rs4449637,rsl6922399,rsl0887 094,rsl7349904,rs764 9266, rs527241, rsl 6880282, rsll571435,rsl93858,rsl513199,rslll66969,rs6800929,rs25 89623, rsl7655252, rsll710358,rsl0007427,rsll829571, rsl 6857010, rs6838769, rs6099735 ,rsl617136,rs7193807, rsl7612917, rs4974261, rsl2890287,rs7202761, rsll803956,rs6230 21,rs7679527,rs6114487,rs9427501,rs2787899,rsl347630,rs35102 703,rsl7702998,rs660 2773, rsll23893, rs7166202, rs9990031,rs4513278, rs6449887, rs7216890, rs6699955,rsl77 12721,rsll764440,rsl490299, rsl0089040,rs8004872, rs6493894, rs 6583901, rs7359403,rs 9406025, rsl311245, rs6068521, rs2711100, rsl59743, rslO813853, rs4870981, rsl7033070,r s598126,rs6862648, rs2162987, rsl7514713, rs936671,rsl7664588, rs7017809,rs2168996, r sl2491721, rs4751252, rs3099154,rs6998642, rsl904775, rsl0169643,rs6837917, rs2109004 ,rsl997498, rs2497080, rs329783 _f rsl535359,rs766521,rsl2305323,rs4296198, rs2282524, rs301506,rs9388761,rsl7186926,rsl2705276,rsl7008480,rsl25680 99,rsl98664,rs773073 3,rsl0224002,rsl2866736,rsl2613663,rs9558313,rsl2960691,rsl5 58988,rsl0238177,rs2 674614,rsl7821187,rsl555394,rsl7345745,rs9930943,rs544588,rs 7784902,rs4407384,rs 699246, rs7750787,rslll37006,rs9880223,rsl561380,rs6542706,rsl453243 , rsl2999675,r sl7719838,rs2736177,rs9289468,rs2615923,rsl893316,rsl2205636 ,rsl0844755,rsl02496 7 I,rs6944789, rs8136239, rsl548801, rsl2636390,rs9375122,rs2651982, rs2112270,rs7834 293,rsl259494,rsl3101772,rslll03796,rs6056100,rsl505463,rsl0 871290,rs2715977,rsl 7106988,rsl68525,rsl7079604,fs2413969,rsl909935,rsϊl211654, rs4377648,rsi0798349, rs7512872,rsl53159,rs215902,rsl2616543, rs2766113, rs7707575, rs387336, rs2468856, rs 10957262, rs4686710, rsl429573, rsl0939851,rs628458, rsl2790605, rs4493378, rs5751188, rsl6838282,rsl20267O0,rs7755109,rsll079784,rs2213735,rsl0493 379,rs6658141,rs7989 813, rsll258916, rs2066331,rs4531379,rs2009378,rs4575593, rs4747262, rs4577696, rs 658 0417, rs2798379,rsl7439813, rs203415, rs6754599, rs7719524, rsl 6935052, rs9863228, rs29 62072,rsl7144166,rs6469409,rsl87804,rs7007919,rs8074124,rs80 80590,rsl539852,rsl4 0154,rs3814395,rs748945,rsl0988264,rs3827869,rsl0206247,rs22 99692,rsl500258,rs78 43729, rs340260,rs4075116, rsl7752832,rs7601020, rs2194980, rs2283839,rsl2494349, rsl 552859, rs2642124,rs7486236, rsl0903250,rs7587759,rs2071565,rs7633306, rsl7611274, r sll229894,rs2530309,rs7612873, rs7462529, rsl7052487 ,rsl935531,rs6468889, rs7753816 ,rs7152627,rs9466287,rs8074708,rsl705236,rs2151754,rsll75316 2,rsl6894918,rs29797 15,rs6502040,rs9923128,rsl0173566,rsl7719647,rs7199578,rsl88 5449,rsl0885533,rs98 94837,rsl6956956,rs6592087,rsl7423995,rs778292 _f rsl436512,rsl409968,rsl2282861,rs 9327919, rs4950054, rs7869397, rsllO86494, rslll44020, rsl 969050, rsl 6861358, rs6959808 ,rsl2226648, rs8096880, rs2979831, rs2957737, rslO148889, rs7997361, rs9968403, rs41487 35, rs7300145, rs3125704,rsl296549, rs9450072, rs7985450, rsl2501935, rs2045797, rs2907 573,rsl0803339,rs7037490,rs7556367,rs4673886,rs2436893,rsl02 02054,rs29675,rs4417

Table 13 -17-

998, rsll627126,rs4072082,rs6422142,rsl6928354,rsl7068137,rsl2076 230,rs9842824, rs 12792346, rs40088, rs4764584, rs34469004, rs6464215, rs7597064,rsl2280198,rsl0739082, rs4282203,rs2046416,rs258570,rsll096727,rsll684634,rsl365492 ,rsl729917,rsl049246 0,rs4668298, rsl 62429, rs7089495, rsl7662369, rsll235178,rsl6919688,rsl934620, rsl 686 9423, rsl7187817,rsl7619330, rsl7551573, rs558290, rs38808, rs2108056, rsll842552, rsll

769043,rsl7680958,rsl7215501,rs6022909,rs2269724,rs433417 6,rslll38606,rsl0015508 , rsll 602473, rsll593247, rs4745672, rsl 683724, rsl0004440, rsl2425125,rsl384565, rs730 6435, rs6783531,rsl868072,rsl7112847, rsl53734,rs9356383,rsl2457251,rsl0015752, rsl 2086665, rsl2161817,rsl7022165,rsl595724,rs6072998,rs4142005, rslll52990,rs3807707 ,rsl602,rsl2101584,rs790286, rsllO84109, rs6461202, rsl 6971953, rs7182409, rslO892657 ,rs2141326, rs750832,rsl2701773,rsl882587,rsl0269821, rs819855, rs8017342,rs588837, rsl7008611, rs6908263, rslO799324, rsl7200475,rsl0932501,rs2241064, rs2071025,rs3093 704,rsl0936577,rs35271,rsl958513,rsl7583892,rsl2123168,rs671 7858,rsl488281,rs648 6178, rsl3387555,rs244783, rsl2499508, rs8062216,rs2306851,rs7331080,rsl2503907,rs7 640046,rs7085458,rs7149784,rs4858888,rs9311026,rs2336377,rs9 332454,rsl6920943,rs 6486303, rs2008159, rsl7693924, rs7658103, rs4053966, rs4469035, rs28695838, rsl.3131758 ,rs6485142,rs826491,rsl0237641,rsl0737030,rs6426937,rsl36047 8,rsl3269287,rs49645

86,rsl2207298,rs9332852,rs613238,rs6583442,rsl7145135,rs3 54784,rs9520076,rsl3196 03,rsl0741098,rs884126,rsl014907,rsl3108845,rsl7472113,rs256 4873,rsl7725929,rs23 06702, rs224644, rs4912929, rs7534148, rsl481397, rs3122164,rs2956593,rs9750167,rs730 3356,rsl793316,rs4777391,rsl438937,rsl0107413,rs956457,rs744 910,rsl7471243,rsll0 48910,rsl0507428,rs6884453,rs2638245,rslll38012,rsl7001267,r s9830354,rsl340117,r s7530922,rsl0252707,rsl3387245,rsl834821,rsl6878834,rs831429 ,rs2115652,rs833986, rs6981922,rsl512551,rs7136340,rs34473019, rslll53884,rs2089756, rsl923256,rs731578 I,rs566647,rs403583, rsll060071,rsl360338,rsl991152,rs659555,rs994783,rs6556460, r sl333096,rsll263693, rs437909, rs9898251,rs9311213,rs2677834,rsl7618560, rs2153297, rsll684453, rsl955628,rs675654,rs7099585,rs2797275, rsll070411, rs4681556, rsl684687 3,rsll946434,rsl3423523,rs9949178,rs870852,rsl2143786,rsl527 296,rsl0416775,rs274 0791,rs2103290,rsl948862,rs9812475,rsl536184,rs7802229,rs848 644,rs2235546,rsl755 9514,rs6013046,rsl942180,rsl432231,rs4630899,rs894151,rs6662 879,rs7207252,rs2552 991,rsl2604198,rsll847204,rsl0911621,rs484213,rs7799181,rs57 3449,rsl2712498,rs95 76332, rslll25815,rs7099285,rsl0845892, rsll206912,rsl368242,rs7579959,rsl0972919, rsl0248895,rsl0109008,rsl6968601,rsl888229,rsl7302707,rsl815 907,rsl454484,rs9367 160, rsl793426, rsl7010575,rs9470265,rs7123301, rsl540394,rs366842,rs2646320, rsl704 1564, rs6511703,rsl415774, rs877531,rs2623421, rs998789,rs559150,rs2877964, rsllll76 7,rsl6934692,rsll659925,rs4236441,rs957255,rsl7075276,rs7638 292,rs2124141,rs7946 872, rs2960157,rsl538095, rsl 6960931, rs3801308,rs7655750,rs4969069, rsl7200818,rsl6 4712,rsll974649,rsl321156,rsl928361,rs4741629,rs603497,rs276 821,rs384867,rs95866 ,rs9579159,rsl7780920,rs2114582,rs2288806,rsl0887794,rsl0933 253,rs882238,rsl7698 963,rs819457,rs2028057,rs9876322,rslll74538,rs6991400,rsll46 814,rsl7459630,rs288 7286, rsll732672,rs9520714,rsl3386066,rsl7140056,rs6453835,rs98459 65, rslO193438, r s3106428,rsl7164117, rsl87985, rsl7157177, rs38437,rsl373865, rsl2332452, rsl7780429, rs7627847, rsl7031974,rs9291837, rs687582,rsl6932458,rsl3070884,rs6810699,rsl03106 3,rsl2522161,rs7943688,rsl953196,rs7731633,rs7025683,rsl0910 118,rs7517978,rs7179 358, rs4308568, rs7550957, rsll681243, rsl49319, rsl0881207, rsl2708960, rs649785, rs646 9204,rsll854579,rsl2498687,rsl7197481,rsll040408,rsl2189025, rs2223027,rs9926529, rs682533,rs6553786,rsl0808158,rsl2693792,rsll92388,rsl705177 7,rsl62454,rs7296993 ,rs2478046, rsll743010, rs9929390, rsl7199159, rslO72198, rsl2613727, rslO122135, rsl25 26001, rsl6888859,rsl6911549, rs2246671, rs7639607, rsll 971971, rsl3260708, rsll 697805 ,rsl7005974,rs6877684,rs9955849,rsl525582,rs6928475,rs991690 4,rsl0781257,rsl7095 472, rsl0910359,rs4885971,rsl2042936,rs7117776, rs6876638, rs2490806, rs7895623, rsl7 013965, rs6882351,rsl539896,rsl0835065,rs2099068,rs3095798,rsl711989 6, rsll600801, rs9487242,rslll87960,rsl7315466,rs298149,rsl7493763,rsl69187 99,rsl0936462,rsl083 3015, rs4716132, rs3814358, rsl7738298,rs4871004, rs506932,rsl983805,rsll628605, rslO 023214, rsl7055158,rs7595960,rs6849208, rs3953508,rs9914077, rs640052, rsllδ 63214, rs 7146730,rs2803461,rsl7384892,rs221724,rsl71336,rsl770909,rsl 7511324,rsl7644017,r s7788617,rs9831948,rs9445305,rs205755,rsl0777032,rs2584622,r s2189106,rs6675190,r

Table 13 -18-

sl2630068,rs4422804, rs2342216,rsl534139, rs4762419, rs7433184, rs604708, rs7295594,r sl6903421,rs2962284,rs6775003,rsl6950293,rsl7119271, rsl323420, rs9858318,rs311266 0,rs4753195,rs3002684,rs6733823,rs7544351,rs9536946,rs224437 2,rs9408638,rsl60620 0,rs7932247, rs848733, rsll726974,rsl2650282,rs690474, rsl7225298,rsl0984069, rsl878 577,rs546685,rsl0147672,rsl2703406,rsl2385690,rs4784852,rs96 77221,rs7662436,rsl3 099487, rs4252612, rs4686783, rsl2486603, rs4660590, rsl0989523,rsl0103535,rs9596891, rsll981294,rs2274914,rs4890971,rsll592925,rs2013021,rsl58044 1,rs2701632,rs768489 ,rsl6841744, rslO736889, rs7805462, rsll 620231, rs6814109, rs3974323, rs7111107, rsl259 5609, rs328731,rs3094629, rs829696,rs7260635,rs4579792, rs4330751, rs9443027, rs25423 ,rs4456647,rs7586635,rsl7592462,rs7084532,rs7751296,rs678230 7,rsl7886456,rsl4993 48,rsl0830359,rs530272,rsl7139683,rs895901,rsll617359,rs6717 716,rsllll4849,rs606 8809, rsl848514, rslO962472, rsl 609034, rsll030119,rslll78985, rsl3005371,rsl565068,r s6664760,rs7333137,rs7864448,rsl0859419,rs7637842,rs2239188, rsll755344,rsll83024 I,rsl2972811,rsll753294,rs6078040,rs6881153,rsl0230949, rsl3256068, rsll 931209, rs3 924753, rs6556732, rsl 6973845, rs7722766, rs7539067,rs6798232, rs6953339,rsl416144, rs 10170220, rsl7250963,rs4399009, rs9353875,rs270166,rs9316974,rs2807619, rsll783878, rs2591018,rs7654002, rsi7725004,rs323847, rsl6945905, rs6475390, rs4916821, rs4287665 ,rsl389858,rsl0025495,rs33964061,rs347684,rsl2073300,rs72576 13,rs7972752,rs75444 26,rs2748938,rs7839680,rs7089593,rs923573,rsl821449,rsl43847 1,rsl3119119,rs95371 93, rs991471, rslO272488, rsl479164, rsl2698360, rs216480, rsl2613538, rs4665744, rsl206 37 l,rs6508964, rsl2907890, rs7576647, rs425571,rsl2515326,rs2128883,rs4299738, rsl90 4258, rsl413707, rsl863975,rsl7096670,rsl7580694,rsl7331811,rsl7613171 ,rs2818766,r S9677486, rs7046886, rsl 1102772, rs2049104, rsll49005, rsl494775, rs6493395, rs2940531, rs4459895, rsl2170325,rs6833480, rs6817560, rsl962914,rs3738374,rsl3323544,rs250190 I,rsl523476, rs4678788, rsll263804,rsl0996377,rs7982706,rsl7387963,rsll768025, rs68 75036, rsll866836, rs310929,rsl994375, rs854275, rs4794347, rs539181,rs3796758, rsl696 2345,rs9595835,rs4398807,rsl2900849,rslll70826,rsl331855,rsl l500866,rsl550644,rs 11023096, rs6843867, rs7165938, rsllO33457, rs7536088, rs9564096, rsl693424 , rsl286885, rsll038752,rsl6956751,rs2966757,rs948324, rs2327803,rsl2560357,rsl482570, rs221943 l,rslll42476,rsl0471199,rs6986467,rsl2920377,rsl7717583,rs67 51863,rs5007121,rs48 44381,rsl6879113,rs788727,rs7730471,rsll060812,rsl0753758,rs 7956184,rs3099800,rs 17488303, rs6602515,rslll46030, rs4977937, rsl962785,rslll66411, rsl3145953,rsl26228 10,rsll212569,rsl433943,rs9373259,rsl0033893,rsl95397,rsl629 705,rs7071521,rs4177 81,rsl7643040,rsl2825420,rsll008621,rslll04921,rsl2990473,rs 7170060,rs9297806,rs 12303068, rsl906694,rsl870384,rsl0799972, rs505963,rsl943917, rsl889855, rsll619090, rsl0749750,rsl0035331,rsl2916515,rsl3402575,rsl2443224,rs379 4075,rs6802433,rs489 1159, rs34905687, rs2993561,rs7597274, rs296034,rs3777142,rsl713731,rs4706043, rslOO 21848,rs835067,rs9540262,rsl820646,rs2278149,rs565976,rs8850 85,rsl0967973,rs7024 102,rs7564893,rs8026788,rslll00551,rsl7262662,rsll085876,rs2 469837,rs9930513,rsl 6960880, rsll962094,rs9402030, rs2447179, rslll65061,rsl7151923,rsl570582,rs4303127 ,rsl821685,rs974873,rs6684543,rs6747078,rsl7081408,rs4853163 ,rsll907451,rs483472 3,rs7820431,rs7788425,rs6577357,rs9372226,rs9317693,rs461279 1,rsl2612329,rs95415 33, rs2523881,rs948107, rs9821339, rsl 6972477, rslO123219,rs4074922, rsll208227,rs203 7518,rsl6928311,rs7988412,rs504836,rs2880414,rsll254640,rs68 19071,rs6783449,rs94 28822,rs7802177,rs6036534,rsl6895780,rsl2098413,rsl6974712,r s2349436,rsl2713210, rs4917833, rs7606525, rs9865369, rsl372330, rs2046845, rs7093915, rs7432657, rslll3816, rslll55927,rs4971282,rs2955002,rsl2219858,rsll241621,rs72949 43,rs776822,rsl66883 4,rs4720884,rs6963035,rs7870616,rs3772019,rsl7121410,rs44325 91,rs8176126,rs20797 14,rs2791465,rs4895829,rs6713136,rsll578004,rsll827026,rsll7 81395,rs9504900,rsl7 075386,rsl2488889,rs6592621,rsl7012735,rsl416379,rsl329701,r s7976757,rs4731707,r s474519,rs384620,rs8084749,rs7934077,rsll808604,rs6590202,rs 9525844,rs686543,rsl 583124,rs8052463,rsl816740,rsl0010798,rs2426403,rs448465,rs6 474388,rsl7063224,rs 9313398, rs2112783,rs3824047, rs2965935,rsl2441720, rsl2503955,rs879068,rs4403687, r sllOδl 691, rsll886533, rs7181384, rsl3334953, rs2290128,rsl0042848, rsl2718627, rs7760 316,rsll812286,rs218222,rsl7409254,rs6708638,rs7648156,rs643 8615,rs2967737,rsl43 3914,rs6009151,rs6964431,rsl744416,rs9547641,rsl7058404,rs78 28288,rs301930,rs718 3186,rsl0918809,rsl3112427,rsl434277,rs8092033,rs285099,rsl6 845646,rsl0000748,rs

Table 13 -19-

16825445,rsl782076,rsl2173152,rs2716960,rs910253,rsl00001 7,rs4794427,rs4837732,r sl2443360,rs357752,rs7816827,rs7215526,rsl7069706,rsl326715, rs6805463,rsl7748111 ,rsll94029, rsl6865600, rs621363,rs6781216, rs6576802,rsl532421, rsl2596723,rsl91817 3,rs9662388,rsll959939,rs9595967,rsl7029269,rs2943791,rs9920 573,rs9537824,rsl322 460,rs284907,rsl7082690,rsll710959,rslll95998,rsl7740268,rs7 827291,rsl7575791,rs 4548577,rs4705028,rs6736216,rs7856137,rs4098663,rs783968,rsl 2311409,rs9351605,rs 10981329, rs675450, rsl3269635,rs7207368,rsl6851773,rs956527,rs9573626,rs6557346 , r s4470917, rsl079082,rsl7161625,rsl713551,rs6691727,rsl7599703,rsl08302 07,rs378437 4,rs7022431,rsll675731,rsl7152488,rsl0943371,rsll755501,rs71 03691,rs2178493,rs57 45391,rsl081158,rs873843,rs9587586,rs2172478,rs4513409,rs602 2677,rslll0256,rsl71 96873,rsl0891731,rs2097914,rsl871289,rsl59969,rs4872456,rsl0 028441,rsl0910407,rs 11676923,rs2892812,rsl7713744,rsll862324,rs9464315,rs9377649 ,rs7311105,rsl701179 9,rs7341167,rsl3189339,rs2238149,rs9850655,rs9302049,rs28216 8,rsll239271,rsl3415 97, rs9945716, rslO798707, rs7597315,rs9444504, rs9383242,rs9458, rsl576594, rsll25770 7,rs2038784,rsl7216066,rs492237,rsl414169,rs9950064,rs984616 3,rs9601047,rs644197 0,rs7874383,rs7692721,rs4791481,rs514001,rsl2596025,rsll7126 82,rsll005065,rs7203 335,rsl869133,rslll73279,rsl7120838,rsl360812,rsl0017663,rs9 318666,rsll040016,rs 9971954, rs362075,rs236170,rsl 6900136, rsl6951574,rs4858561, rs7105477, rs554161, rs4 853647,rsl0188713,rsl3033132,rs4245377,rsll239623,rsl6927892 ,rsl517721,rs7656442 ,rsl2005362,rsl0507922, rsl6824535, rs7419377, rs4586096,rsll706277,rs6018100,rs657 0746,rsl7675097,rsllll9795,rs2173682,rs4141058,rs7359491,rsl 7686577,rs2244834,rs 63482, rs4515575,rs479333, rsl7299691, rsl532061, rs3846483, rs2441701, rsl7654732, rsl 863504, rs9358463, rs6698696, rsl504394,rsl0744591, rsl0049684, rsl6939026, rs2113417, rs767177, rslO012403, rs2316972, rs7924984, rs7814326, rsl7077264,rsl7476016, rsll6572 70,rsl7077722,rs7185087,rs6440052,rsl7653286,rsl219505,rsl56 2495,rs6583607,rsl69 83952, rs517350,rs6449748, rs7172792, rslO767806, rs2863139, rs6965541,rs7581784,rsl2 885819, rs759658,rsl3379966, rs7594046, rslO37988, rs7039358,rs7621516, rsl528688, rsl 0258132, rsl0090950,rs6034006,rs7313691,rs2074151, rs2523638,rsl7398704,rsl0448118 ,rsl0465698, rs9531827,rs6903956,rs4376999, rs4909018, rs7044562, rsl2595096,rsl0254 192,rs488662,rs2178070,rsl2530731,rs2260959,rs4505594,rsl692 4636,rs2954892,rsl40 4616,rs6764939,rsl6914146,rs2790179,rs208976,rs602340,rs6969 223,rsll88752,rsll89 4322,rsl470984,rsl3184989,rs4448049,rsl3149222,rsl7197619,rs l205235,rs9529625,rs 7966836, rs4558460, rsl007586, rs7082331,rsl7346504, rsl0167210,rs4719885, rs2783122, rs35126744,rs2318872,rsll013046,rsl2603993,rs327434,rs292814 0,rs6432680,rsll7879 70,rsl2661208,rs734512,rsl2635063,rsl577749,rs6548780,rsl447 285,rsl7440213,rs600 1031,rs2968845,rsl7038857,rs9469491,rs8050692,rs7611514,rsl6 856652,rsl872785,rs8 030325, rsl7210543,rs8075367,rsl7767553, rs2055375,rs6433680, rsll682655, rs7018304, rs4906795, rsl0181654,rs272938,rsll817793, rsl3207114, rs7236575,rs2292714, rsl70592 37, rs4871395, rs336673, rs3858853, rsl7502658, rs2250205, rs7019416, rsl7657848, rsllOO 2449,rsl217225,rs9315451,rsl570212,rs2037639,rsl6944815,rs79 78934,rs6894272,rsl8 37236, rs7830691,rs3912603,rs849565, rsll966550,rs5749016, rsl3082882,rs6821712, rs2 453179,rs287516,rs884128,rsl6936543,rsl2523424,rs6542801,rsl 6969075,rs991869,rs8 025220, rs7649317, rsl453223,rs6785027,rs7665411, rs4859013, rs2193604,rs6903663,rs2 191435, rsl516493, rsl3143295, rs2576997, rsl3437303, rsl6946188, rs6439578, rsl3114301 ,rs398770,rsl0764936, rsl2993624, rs6562028,rs9556151,rsl7779951, rs2839754,rsl9515 39,rsl573023,rs3846548,rsl2316043,rsl2923214,rs3786185,rs214 9063,rs353121,rs4384 911,rs2046183,rsl0886419,rs2600251,rsl323984,rsl7686634,rs46 74646,rsl373259,rs45 24581, rs4897051, rs2872507,rsl2317299,rsl015361,rs4573692, rs2455853, rsl 904442, rsl 7831166, rs7567706,rs6990363,rs3747575, rs6592528,rsl0094510, rsl7366568,rsl846334, rs6928603, rs3797621, rsl2212981, rsl 1133860, rs946819, rslO173529, rsll99977, rs649274 0,rs7850199,rsl7441111,rs6702110,rsl2571712,rsl2078461,rs407 3433,rs3753377,rs904 821, rs2894180, rsl030176, rsl0832956,rs7959282, rsl2763142, rs8056660,rsl2215896, rs4 645268,rsl583670,rs3826785,rs962320,rsl047813,rsl6822665,rs4 925223,rs6850107,rsl 417437,rs2093154,rsl7167325,rs919165,rsl0428851,rsl7340116,r s7716184,rsl7647222, rs7789522,rs7290681,rs3099106,rsl2085319,rs7090721,rsll09861 ,rsl7762226,rs691979 8,rsl7521925,rs4286228,rs960996,rsl7088896,rsl6849387,rsl259 7219,rs7113370,rsl02 69774, rsl2116790, rsl2659729, rs2474251, rs9315980,rs4870308, rs2891530, rs9389777,rs

Table 13 -20-

10060331, rsll45076, rsll777887,rs7754383,rs2282635,rs7155973,rs7166128, rs2321884, rs754037,rs898864, rs6781294,rsll763695, rs9834182, rs8007114,rs823510,rsll59658,rs 16840586,rsl870954,rs4380249,rsl2406906,rs4754927,rs9303746, rsl2404058,rsl047746 3,rs9342288,rsl6924016,rs7899959,rs486253,rs6680046,rsl75111 38,rs2502836,rs74120 3, rsl0793904,rs814586, rs7151711, rsl2891826,rs341988, rs7501644, rs4777711, rslO8345 61,rs7081421,rs4977499,rs3845386,rsll747890,rs4858348,rs2589 446,rsl2694027,rs966 6264,rsl2442869,rsll562945,rsl7064201,rs2315921,rsl7097704,r s33387,rslll86480,rs 6967001, rsl7227554,rs9636018,rsl7681152, rs6730936, rs4973469, rs7035561, rs2324129, rsl3357293,rs4917690, rs731945, rsl360985, rs7538871, rsl 6822455, rs7106, rs6702126, rs 10009099, rs9325685,rs3213798,rs2455033, rsl3061242,rsl370079,rs2026342,rs7334107, rs4372750, rs814202,rs9804151, rsl2054067, rs3811387, rsl0459871,rs7584506,rsl735097 0,rs9373904,rs7785651,rs203579, rs279928, rsl7587182, rs9907607,rsll015984,rs790518 4,rs7034748,rs7242599,rs9394115,rsl0953976,rsl2517906,rs9513 48,rs2301742,rs43033 06,rs4797209,rs7154643,rsl2332207,rsl3259937,rs6835122,rsl94 0745,rs9644226,rsl76 65636, rs3785935,rsll264875, rs4321356, rs4322991, rslO461198, rs4811210, rsll900317,r s7150418, rsll209185,rs4675814, rsl2981782,rs2898041,rs2602710, rs7655566, rs9582755 ,rs799940, rsl0423964 , rsl329493, rs34618032, rsl515179, rsl7751115, rsll228612, rslO83 0135, rs814398, rsllO57388, rsll670606, rs9649417, rs4810605, rs4579280, rsl359660, rsll 047519, rsl450542, rs3114653, rs4548259, rsl924762, rs727335, rsl2617590, rs9824873, rsl 3136008, rsllO74079, rs7589821, rs4880140,rsl3030671,rs8038531,rs9957166, rsl7562898 ,rsl0183914,rs2579551,rsl2646153,rsl912,rsl0911861,rs851420, rs7318881,rs4412729, rsl7503003,rsl476462,rs5757715,rs4326106,rslll74592,rslll079 18,rs7963858,rsl5405 8,rs8010111,rs2714614,rsl2653944,rs9514578,rs3743859,rsl0171 238,rsl7113589,rs250 010,rsl0149030,rsll07554,rs4893866,rsl2606550,rsl0236767,rs6 599257,rsl0987552,rs 2655129, rs7862181, rs2241649, rsl0999304 , rs6930922, rsl0911047, rsl461100, rs7826539, rs9674522, rs4800833,rs7096799, rsll949105, rsl743257, rsllll5628,rsl2581525,rsl3354 690,rs4751814,rsl7171658,rs9934125,rsll021731,rs847812,rs776 5437,rsl865586,rsl88 3834, rsll250163, rs2271293, rsl2188163, rs3895665, rs2375253,rs 6665090, rsl40567, rs77 35361, rs8024223, rs9838500,rs8071524, rsl2616209,rs4625578, rsl028724,rsl333170,rs7 484818,rs4906632,rs7324699,rs9313506,rs6730107,rs6844265,rsl 6903479,rsl7628722,r sl0957017,rs704497,rs2034747,rs2958858,rsl2597881,rs2174569, rs6920170,rsl7451111 ,rs2269975,rs6014763,rsl7722872,rs4764949,rs2047,rs7286735,r sl2591792,rs282796,r Sl7309928,rsl0923084,rsl7202079,rsl0838086,rsl429987,rs79797 76,rsl6951344,rs9281 95,rsl267494,rsl0750687,rs35143986,rsl0112136,rs9655313,rs95 74869,rs7721185,rsl7 127971,rs420033,rsl3016143,rsl0470569,rs2276346,rs7217504,rs 7970587,rsl0132268,r s4955274, rsl478285,rs9949988, rs2458064,rs7371285, rs9398953, rsl7053102,rs2716182, rsl2744616,rs6461847,rsll56562,rsl2632378,rsl0942232,rs44428 21,rsl7513961,rs6242 85,rs870695,rs6581046,rs9874979,rs2713670,rs2503451,rsl32315 78,rsll072826,rsl240 8746,rsl2044788,rs7543834,rs9327870,rsl0141075,rs4890620,rsl 039302,rsl0482642,rs 7326514, rs206420, rsl 6864358, rs2989476, rsl2704036, rslO934975, rs2344827, rs2220504, rs9289851,rs3770879,rs282335,rsl0097675,rsl490881,rsl2999055 ,rs249387,rsll264728 ,rsl345214,rs7591265,rs4877174,rsll99666,rs239967,rs7108670, rs667108,rsl863642,r Sll617955,rsl3081038,rs4500059,rs2068920,rs9352715,rsl317459 ,rs2270637,rs7257950 ,rs2572109,rs7582658,rs2425920,rs3774237,rs2259964,rs2304561 ,rs4819956,rsl759285 6,rsll225081,rs3775823,rsl2544393,rsl7519429,rs6039386,rs339 77056,rsl615640,rs48 52939,rs7378179,rslll21317,rs9600681,rs3785632,rs3851364,rsl 7343583,rsl0755068,r sl6873324,rs4725805, rsl2313324,rs382323,rs4308687, rs274606, rsl2349388, rsl7108004 ,rs6786199,rs4266962,rs323397,rs6478626,rs2717485,rs8085123, rs7574068,rs3809101, rs99595,rsl985933,rs7623587,rs4717756,rs4441836,rs7712742,rs 8000386,rsll940245,r S7536659, rsl 6989540,rs6076036, rs969751,rs741719, rsl0483286, rsl767742, rs2032553,r sl0076,rs7643025,rsl3392863,rs6749757,rs2878258,rsl3025711,r s3213977,rsl713448,r s9497673,rs7003213,rsll072031,rs4862559,rs7750450,rs791504,r sl0429417,rs6827845, rsl7690958,rsl2699994, rsl7676830, rs346500, rs4888638, rs4122861, rsl7295457, rsl3085 088,rs9294824,rsl0805692,rs2863174,rs9788859,rsl0834409,rsl2 409926,rs3818279,rsl 781624, rsll766913,rsl336128,rsl0920303,rsl7209741,rsl7084742,rs9709 83,rsl2539364 ,rsl032293,rsl6879804, rs9864056, rsl 641229, rsl7623313, rsll934851, rs3900024,rsl969 759,rsl0498286,rs4371408,rsl0843855,rs2647952,rs7425417,rs21 15143,rsl427087,rs23

Table 13 -21-

80173, rsl7000947,rs3752559,rsl2120921,rs4535743, rs6120757,rs6414025, rs8089695, rs 1584573, rsll664013,rsl7112354,rs7694748,rs8058650,rs2080681,rsl02280 39,rsll71862 9,rsl0877689,rsl7219063,rs745218,rs9888320,rs7546586,rs98696 46,rs35706,rsl381488 ,rs8045523, rsl7591814,rs2092096,rs6035647,rs4310100, rsl7284313, rsl0865359,rsl751 9385, rsllll267,rs2344184, rsllO76300, rsl562325,rs4273613, rsl883328,rsl7134231, rs2 210191, rs7924834, rs525983, rsl001953, rs722939, rsll012980, rs2939374 , rsll708280, rsl 7646960,rsll085419,rs6719949,rs2973677,rsl369327,rs4945186,r s6109773,rs7768053,r sl2440774,rsl6893953,rs7764875,rs7512061,rs514931,rsl0885681 ,rs2876789,rs7812233 ,rs2785262,rs7437897,rs285736,rsl7146285, rsl2037818, rsl7699483, rs2290864, rsl 6980 045,rs901795,rs6581336,rsl6971832,rs4241407,rs6070472,rsl283 320,rs2510596,rsl259 2730, rs2959004, rs6997637, rs2506761,rs736239,rsl0833821,rs7182216,rs7781814, rs700 8285, rsl6992494, rs2117966, rsl2625378,rsl0245396, rsl579103, rs8048114, rs4646070, rs 12548289, rs2089722,rsl0483392, rs4981791, rsl2537474, rs2473929, rsl6836900,rs490081 6, rs6558578,rsl6924617, rs3119187,rs7535159,rslll85211,rs7240280, rs4369215, rsl484 618,rs6487290,rs6018788,rsll606448,rsll98825,rsl991127,rs248 9386,rs2958188,rs991 5259,rs2240492,rs4451252,rsl350678,rs6884826,rsl0893216,rs69 31523,rsl0938166,rs8 50535, rsl509355,rslll58558,rs4307013,rsll711999,rsl0950811;rsl2338 658,rs7567895, rs4915423,rs7085222,rs7757336,rsl2673387,rs6538481,rs4696646 ,rsl3060688,rs207445 2, rs7633686, rs2302777,rsl2994268,rsl0457800, rs6037166, rsl 6996123, rs7483317, rsl75 83667, rs4279854, rsl6964983, rsl0498318, rsl7103170, rsl2887285, rsll754612, rs4812357 ,rsl046112,rs7092250,rs357958,rs7126443,rsl0852156,rs4518532 ,rs7674339,rs6085920 ,rs2848852,rs4890633,rs985572,rsl7307939,rs3846169,rsl010105 5,rs9384860,rs980622 2,rsl7025744,rs4794220,rs4979800,rs7160284,rs32170,rs6763060 ,rs7023670,rsl200530 ,rs4476147,rsl2502103,rs7868020,rs4978781,rsl7104442,rsl9569 64,rsl0101390,rs5677 78, rs6728812, rs4732625, rs2476468, rs9289185, rs712325, rsl938541,rs 6439962, rsl73659 48,rsl7210621,rs2279237,rs7207479,rs4736856,rs791543,rsl0000 50,rsl0817843,rs9946 720,rsll88184,rsl950367,rs3913714,rs7634403,rs802736,rs48821 32,rsll249429,rs4143 818,rs4141996,rs2383643,rsll748913,rs7017860,rs2617648,rs430 102,rs6783462,rs7805 021,rsl0422455,rsl481280,rs7646760,rs7566221,rs831663,rs3814 217,rs6857762,rsl291 9014, rs2455280,rslll23564,rsll86765, rsl879396, rsl0735302,rs2110465, rsll765593, rs 5765620, rs2221075,rs3804162, rs6474182, rs6465748, rs9789123, rsl7716016, rs9403525, r sl3096481,rs7079228,rs9304480,rs7576012,rs262265,rs2034412,r sl7433703,rsl2428,rs 10853822, rs553648, rs7174305, rs9646947, rs2010326,rs7816535,rsl987295,rs4854547, rs 11638539, rslll68561,rsl7781350,rs9994130, rs2146229, rs2979029, rslO245553, rsl71121 97,rs7154646,rs2276643,rsll686210,rs9323058,rs4759061,rs9524 371,rs7099511,rsl086 0618,rs4074448,rsl40610,rs2070314,rsl7417696,rsl2676064,rs59 8130,rs8056929,rsl69 34875,rsl742092,rsl2786533,rs481234,rsl3129546,rs7154601,rsl 0777915,rs6070848,rs 501955, rsl0779525,rsl7009751,rsl0125521,rs9316367,rs712397, rsl543780, rsl25764 l,r s6769004,rs3951468, rs6680566,rs917403, rs 6022755, rs2636909,rs214511,rs8011828, rs4 122385, rs2161551, rs4386138, rs637990,rs429717, rsl7608186, rs4821990, rs832075,rs277 8252, rs9855113,rs2309316, rslOl 1865, rs2065806,rs4877272, rsl7695923, rsl467260, rs46 98255,rsl3103109,rs2010338,rs7618186,rs881773,rs4930430,rsl7 320342,rs4936444,rs6 979031,rs6424766,rs361467,rsl7777266,rs3740909,rsl7806747,rs 9878394,rs4975533,rs 300912, rsl6896071,rs6848721, rslll 97544, rsl380053,rsl926069, rs9384389, rs4865610, r sl64753,rs3774474,rsl6879704,rs7969512,rs3781298,rs8177586,r sl7188417,rsl449581, rsll951504,rsl0164423,rs7069096,rs4466233, rs7971811, rs6952113,rs289194,rsl342970 8,rsl0033106,rsl7622252,rs3886351,rs6088519,rs2222427,rs7742 748,rs6429966,rsl006 0271,rs7666487,rs9514924,rs824082,rs4900914,rsll51560,rsl204 4179,rs6764167,rsl69 780, rsll884801, rs7930503, rsll023472,rsl7728981,rsl6822339,rsl430565, rs4901047, rs 10853250, rsl907075,rsl242507,rs3783274,rs6452944, rs6012536,rsl7086501, rsl825406, rsl2187728,rs2216730, rsl2277747,rs6501756,rs7642460, rsl2084240,rsl2214123, rs8004 267,rsl0161186,rs4318264,rsl7821664,rs7609803,rsl0213502,rs6 768601,rs4145624,rsl 0790928,rs9877400,rs2059883,rs7823376,rsl0215875,rs7157602,r s4236504,rsl0045449, rs2538909,rsl0086780,rs2471512,rs222765,rs2147692,rs978103,r s9565243,rs9904530,r si 6970784, rsl947465, rs4458523, rsl 6947844, rs2134631, rs4767293, rsl7765313,rs453536 l,rsl380131,rsl7763104,rsl0060763,rs4512036, rs2424906, rs7291782,rsl499968, rs9511 893,rs4663414,rs5746059,rsl7145468,rsl6936729,rsl770319,rsl0 060764,rsl0768960,rs

Table 13 -22-

12563854, rs4621031, rs7642410, rs4596614, rs756658,rs9323264 _f rsl97635,rs6540244, rs4 67998,rs798058,rs2993546,rs3798138,rs556916,rsll683421,rsl73 86406,rs901792,rs340 62534, rs9448911, rs939626,rs6994222,rs 6709233, rslO175791, rs2251422,rsl7356099,rsl 569422,rsl6976950,rsll014374,rs4445847,rs214097,rs2794436,rs l7181845,rs7311238,r S10927864, rs7338251,rsl7807129,rs6715181, rsl288642, rsl725989,rs2793787, rsllO7856 3,rs979120,rs3103268,rsll699044,rsl2117730,rsl0152251,rsl045 2776,rsl490279,rs450 1345, rs9661504,rs3094035, rs318792,rsl2516293,rs2326121,rs7023765,rsll218708,rs30 97891,rsl057293,rs2051007,rsl0149246,rsll045332,rs3794811,rs lll58603,rs2029549,r s9362053,rs3753427,rs8064810,rs7128698,rs8180826,rs6762104,r sl6929516,rs4410449, rs4305691, rs799584, rs6801593,rsl7621800,rs9328208,rsl7059757,rs6669720,rs285383 6 ,rs7577713,rsl0130192,rsl286291,rs7596394,rsl409181,rsl00441 38,rsll744062,rsl704 9262, rsll230061,rs302864, rslll 92197, rs411136, rsl6905946, rs72604 l,rsl952036,rs765 5700,rs7832529,rsl7585041,rsl7119815,rs2270948,rs611076,rs47 88488,rs7898450,rs40

76919,rs35487523,rsl7707070,rsll650366,rsll24952,rs2803989,r s326598,rs4762307,rs 10425230, rsl6968038,rsll767506,rs2306371,rsl2028581,rsl0056564,rsl706 4468, rs4965 177, rsl2133012,rsl0905930,rsl7054463, rsl6929511,rs6051087,rsl 912274, rsll906718,r s9341201, rs6779650, rsl2780145, rsl7656564,rsl890112, rs7967827, rs2025821,rsl713607 8, rsl207121,rs7673097, rs3752109,rs2189599, rsl2674047, rslO246543, rs7139698,rsl357 189,rsl6879378,rs733295,rs6810778,rs7727752,rs9283919,rsl086 5580,rsl7033050,rsl0 182788, rsl0802554,rs782949, rsl7109753, rs7958065, rs7295635, rs7741758, rslll77226,r sl34855,rs4773192,rsl2739961,rsl558286,rsl2708944,rsl0121618 ,rsl7753596,rs803877 3,rs35171095,rs2127224,rsl2609781,rs2799482,rs9400709,rs8062 460,rsl759388,rs2038 398,rs7236642,rsl0936348,rsl464402,rs8075064,rsll38681,rsll2 38326,rs672613,rsl77 83630,rs5999296,rs4377750,rsl0054686,rsl2049968,rs3814533,rs l0835647,rs4975778,r sl7213073,rs470437,rs9398716,rsl0735516,rs555183,rsll48179,r sl541390,rs4764799,r s3755833,rs3796649, rs9488336, rs4899530, rs4309387,rs9633568,rsl889050,rs4938201, r s4934663,rs4301463,rsl7399290,rs8036722,rs4775005,rs2939244, rs4739959,rsl0746798 ,rsl7474056,rsl525287,rs4440261,rsl935743,rs7287595,rs763779 3,rs8013942,rsl70280 81,rs7250708,rs6894826,rsl323068,rs5756339,rs7902125,rs29341 64,rs2909662,rsl4041 84, rs2704259,rs7143627, rs802226,rs7086701, rs4076925, rs540000, rs2047585,rsl686730 5,rsl0804442,rs540497,rsl2331980,rs6969314,rs9902439,rs58212 2,rs7212295,rs953977 ,rsl0764627,rslll53377,rs8055850,rs2551920,rsl859643,rs46512 99,rs7928609,rsl0748 503, rsl7511282,rsl7559464, rs6474952, rs7867072, rsl7780388,rs9861194, rs6660134,rs7 835370,rs2271844,rsl2497461,rsl2640416,rsl882080,rs8090665,r s7501556,rsl445929,r S3734120,rsl0456848,rsl453660,rs6810430,rs2281990,rs4465553, rsl7780175,rsl706032 3,rs7599498,rsl0096531,rs7356554,rs4520934 _f rs580256,rs9310350,rs6729882,rs381555 8,rs2039369,rs3133598,rs905442,rsl0204148,rs6679637,rs254899 7,rs6443904,rs237398 4,rs4144582,rs514974,rs6472155,rs2162382,rs2153878,rs6926560 ,rsl372195,rs705517, rs2051979,rsl0781943,rs4889545,rsl6896853,rsl359490,rsl25159 67,rs773898,rsl00506 89,rs317608,rsl2655977,rs7603456,rs3817772,rsll48552,rs29934 4,rsll227112,rs76244 19, rs7661303, rslO12477, rsl2316906,rs2983713,rs7656477, rs7336759,rs264776, rsl7501 909, rs7950479, rs7957007, rs2132521,rsl2629785, rs7031058,rsll717115,rsl6843251,rs4 996830,rsl69600,rs3750800,rs2605449,rs2303190,rslll34201,rs7 085524,rs7987994,rsl

0895399,rs892113,rs214944,rsl7306391,rs2603779,rsl0444865 ,rs3824133,rs6723614,rs 2623142, rs348007, rsl2868114 , rsll 684998, rs544793, rs7655649, rsl 6909813, rsl943528, r s6875804,rsl514871,rsl0023994,rs7209156,rsl7015957,rs2943656 ,rsl887793,rsl076134 6,rsl917481,rsl0874312,rs6952466,rsl0061689,rs9689350,rs2128 834,rsl610110,rs6827 557, rsl7512698,rs4857989, rsl0431808, rs4851507, rs3755377, rs4431128 , rs6709022, rsl2 546300,rs4958869,rsl78453,rs2288071,rs872068,rs7187296,rsll0 11852,rsl0851266,rs9 529794, rs7969109, rs707635, rs9457203, rsl363350,rs9360075,rslll70486, rs9881375,rs4 492324, rs7006394,rs7921015, rsl7075293, rsl2935578,rsll732932, rs2115151,rsl38351,r sll681519, rsl421972,rs359807,rsl2700545, rs3809178, rsl488047, rs7794569, rslO247386 ,rs602201,rsl7696005,rs2239074,rs9825263,rs997863,rs9814545, rs7324797,rs8092519, rsl345731,rs9746695,rs2116441,rs4957723,rs363620,rs326506,rs 2866240,rs3757916,rs 7140655, rs4857887,rs7267054,rsl2637393,rsl51222,rs941989, rs413420, rs6595734,rs67 54224, rsl554497, rs670073,rsl0899855, rs955734,rsl7099092,rs4074106, rs643602, rsl74 4905,rs2255979,rsll581653,rsl3121097,rs4621891,rs776942,rs29 4465,rsl2633037,rs20

Table 13 -23 -

51607, rs2120992,rs9394508, rsl0410294 ,rs4801190, rsl7099645, rs3900881, rsl370496, rs 870827, rsl894921, rsl2626410, rsl0484152, rsl2152237, rsll5569, rs659964 , rslO460960, r s4259295,rs7972145, rsl2693984, rsl7118712,rs4471558, rs9854454, rs9563616,rs6687387 ,rsl0826259,rs9886374,rsl324414,rs272110,rsl0824419,rsl42914 6,rsll47116,rs736864 ,rs7637650, rsl425522,rs439721, rsl2029417, rsl0822064,rsl766151, rsl0103556,rsl2702 798,rs28420079,rs2578376,rs6976733,rs2024996,rs258082,rsl201 9764,rsl997716,rs929 441,rsl32367,rsl0831907,rs7253024,rs2409629,rsl7792426,rs279 973,rs2665404,rs7585 98,rs7112925,rs6778876,rsl0896444,rsl513331,rslll30214,rs811 9080,rsl3088693,rsl2 602961, rs4778848, rsl6963567,rs6943077, rs2371837, rslll59220,rsll208722,rs6471550, rs2861914, rs2299129, rs6475803, rsl999674 , rs9538998, rslO18954 , rsl807100, rsl7788930 ,rsl0981693,rsl0923755,rsl0087434,rs739710,rs2879812,rsl2285 018,rs663534,rs47689 4,rs4866470,rsl530833,rs8058507,rsl0787490,rs7253502,rs46877 73,rsl2601082,rs4789 947,rs4936278,rsl0762344,rs9827976,rsl2798347,rsl009234,rs22 81266,rsl3078394,rs4 854306, rs4392152, rs7124825, rsl7135053, rs6791710, rs2075270,rsl7611093, rsl7790217, rs9636243,rsll041791,rs701251,rsl2464038,rs8021057,rsl235220 2,rsl6825722,rsll245 257, rs4906417, rs4980075, rs7868316, rsl6940792, rs3559, rsl757156, rs2331653, rs431721 9,rs4727494,rsll772527,rsl0999804,rs756750,rs9636438,rs45239 12,rsll760725,rsl885 191,rs6119304,rs430544,rs9906840,rs7829227,rs4790055,rs65743 63,rs7238739,rs64512 68, rs563118,rs4884052,rsl275996,rs2279053, rs2862353, rsl0893305,rsl810496, rs26019 04,rsl567443,rs7296488,rs300068,rs3972692,rsl2685856,rs89082 4,rs2738042,rs967649 8,rs7001413,rs4911496,rs2189450,rsll027852,rsl7701358,rs3502 0936,rs2906852,rsll0 59265, rsl451770, rsl7175747,rsl482172, rs327719,rsll792219, rs9518187,rs411908 l,rsl 0850715,rs2132433,rs2402110,rs7949244,rsl3221148,rs233479,rs 9445740,rsl970893,rs 3816449, rs3913569,rs8027733,rs503175,rsl2460166, rs716097,rs2980973,rs7141902, rs7 219687,rsl34376,rsl2473965,rs7653408,rsll218828,rsl2594645,r s2207861,rs554795,rs 2102232, rsll793918, rs4585287, rsl496814, rs8001021,rsl05037,rs4765021, rsl7836662,r s2502731,rs6678300,rs4686101, rsll07373,rs2040399, rs3777794, rsl250224,rsl7117333, rs910660,rsl7146532, rsl7828548, rs4642688, rs8092227, rs9515106, rsll236000, rs295691 4,rsl924181,rs800819,rs4749580,rs7911300,rs7173068,rs9675202 ,rs579279,rsl2548622 ,rsl2288225,rsll724759,rsl7292087,rsl0178838,rsl7791273,rs70 31588,rsl936641,rs78 07376,rs4418931,rsl0801047,rsl2673611,rs4739938,rsl0484051,r s8028430,rsl0105748, rs4594032,rsl3101932,rsl330118,rs7019060,rs7742445,rs312351, rs7965352,rsl0767973 ,rs6581804,rsl618433,rsl368085,rs2069476,rsl520013,rs349036, rsl0810132,rs6452065 ,rsl7329424,rs4771934,rslll65443,rsll950429,rs4621443,rsll07 8077,rs6899693,rs703 2364, rs7038186, rsl2060538,rsl283628,rs9872227,rs892192, rs6807821,rs7503175,rsl39 2553,rs7793194,rs2726551,rsl7095157,rsll872835,rs6694477,rs2 953442,rs974846,rsl6 994165, rsl0452669, rs337099,rs7527995,rsl0032280,rsl328714, rs3801983, rslO64005, rs 7648255,rsl7123790,rsl0835974,rs9939485,rsl0782841,rs7316055 ,rs302456,rs6564728, rs9991827,rs6478071,rsl7267769,rsl7137008,rsll778615,rsll563 98,rsll04880,rsl0197 574,rs4316515,rsll263860,rsl424504,rs2356086,rsll58162,rsl71 00849,rsl267585,rs80 50316, rsl7090278,rsl0789792, rsl6948981, rsl7012057, rs2226206, rs6803741, rs6482080, rs4468463,rs2284275,rs7930898,rs6903494,rs9895992,rs4845406, rsl6922823,rsl715407 7,rs862711,rs4298174,rsl2727083,rs4484966,rsl6972996,rsl9567 42,rs6875551,rs99582 93,rsl3397244,rs9349753,rsl3168430,rsl0898685,rs7027937,rsll 643373,rs7529811,rsl 1706837, rs947920, rsl6960333,rs407746, rs3935714,rs9449400, rs4576395, rs4321312, rs4 417749,rs2997726,rsll071851,rs9542714,rsl385436,rs273242,rsl 0818467,rsl2141431,r s26217,rsl7827839,rs301662,rs4743034, rs2058655,rs825398,rs887463, rs4256853, rs561 111, rs732123,rsl331189,rs3736563,rsl80535,rs2121302,rs7850054,rs 265859,rsl495473 ,rsll628435,rsl7032792,rs2140489,rsl2042611,rs2055593,rs4534 94,rsl262235,rs41331 68,rsll063348,rs35576618,rsl273725,rsl3321487,rs7133850,rs58 7882,rsll055275,rs48 00513, rs634234,rs323663,rs4258212,rs7835088,rsll086102, rs4805031, rsl790014, rs954 4420, rs2425247, rs4092400, rs241315, rs4847324, rs6483831, rsl7005976,rs2851092,rsl25 41725,rs2363688,rs983874,rs6906857,rsl7073281,rsl2694096,rsl l886293,rs4633144,rs 6688540,rs6812570,rs2237257,rs460677, rs7614948, rsl2035718, rs4333297, rs803714, rs9 451818,rsl3390952,rs5766418,rsll049416,rsl6875134,rs3118767, rsl7175651,rsll90098 3,rsl2794777,rs7527871,rsl233078,rsl7272607,rsl6982679,rs758 5787,rsl675031,rs451 5425,rs2021780,rsl431230,rs2028830,rsll075884,rs7104405,rsl0 58335,rs2527031,rs57

Table 13 -24-

8032, rsl7493073, rs4243474, rs9397206,rs4021712, rsl491311, rslO218795, rs7199563,rsl 109451,rs4574383,rs878282,rs7572174,rsl0947508,rsl572918,rsl l48652,rs8041025,rs7 615840,rs8123041,rs3802394,rsl393085,rsl7058113,rs7081481,rs 4440098,rs3693,rs471 0979, rsl7348974, rs6546883, rs4456055, rslll74379, rsl0848112, rs9530288, rsll680806, r s7109698, rsl2447938, rsll257367, rsl 670159, rs2068178, rs2127120, rs7151133, rslO7O484 , rsl3219674, rs4253754 , rs4411360, rslO944288, rsl6883860, rs200759, rsl521500, rsll604 871,rs494958, rsl2142130,rs9701451 ,rs4322954, rs9817998, rs9473779, rs4668897, rsl462 203,rs2815371,rs427274,rs2086242,rs7779292,rs7029587,rsl3783 43,rsl429436,rsll699 260, rs7861073,rs4515122,rs2042556,rsl7037693,rsl3271967,rsl35812 9,rs6545800, rs98 59834, rs2191667,rsll693002,rs6942786, rsl418921, rsll952011,rsl455870, rsll656342,r s28624162,rs2236576,rs6606684,rs4969179,rs8054657,rs9644870, rsl7620436,rs973140, rs2072041,rs453,rs4269585,rsl6856766, rs8011499, rsl 960643, rs2817569, rs9888026, rsl 0864304, rs4761933, rs6658131,rs7606492, rs663136,rsl7295401, rs2271315,rsll714605, r S7223010,rsl2988263,rs788985,rsl57646,rs4781572,rs9287609,rs ll067096,rs7345275,r s4541776,rsl7834703,rs6448740,rs3763934,rsl0992471,rs2228527 ,rsl3338089,rs219666 5,rsll623866,rsl60960,rsl3184373,rsll731545,rs9431295,rs6886 243,rs986399,rs46651 02, rsl7179664, rs7083142,rsl367921, rs7553191, rs2721112,rs2035326,rs7904101, rs6584 905,rsl0991231,rsl0811165,rsl7408578,rs829505,rsl0831846,rs6 823383,rs7808032,rsl 0446705,rs2049472,rs2046259,rsl446526,rs6580870,rsl7121053,r sl0979666,rs6916887, rsl0801744,rsl7528695,rsl7772024,rsl7408598,rsl7686529,rsl00 07552,rsl0106758,rs2 485367, rs765807 l,rs2815716,rs631045, rsl7616836, rs7900929, rs620151,rs7027130,rs37 67101, rs8092690, rs3767225,rsl965881,rslll48059, rs6559328,rsl2077397,rs4455277, rs 1351518, rsl6964573, rs823298, rsll695971,rs4651080, rs3800665,rs759358,rs9293983,rs 17198254, rs598418, rs4260241,rs6733029,rs4944512, rs236434, rsll871252,rsl703692,rs 2248435,rsl553903,rs4719813,rs4072714,rsl812855,rs216887,rs7 071484,rs703260,rsll 070264, rs6956298,rs2613144, rsl0037044, rsl0846858, rs4664535, rsl3072789, rsl2196873 ,rs527462,rsl2277946,rs7457213,rs9471366,rs2349058,rs9871401 _# rsl2320293,rs310241 ,rsl6958954,rsl244434,rsll234249,rsl7300302,rsl7796053,rs287 2506,rs7310134,rs426 4508,rsl381353,rsl81949,rs209677,rs879591,rs2732248,rs409144 5,rsl7023753,rs41296 78,rs2206387,rsl0103157,rs250681,rsl324205,rsl0869459,rsl532 479,rsl0850931,rs671 7755,rs2983432,rs7167151,rsl3021276,rsl0808489,rs7574709,rs6 855230,rs794442,rs93 28496,rs3739050,rs798413,rs4980951,rs7666226,rsll934047,rs65 76414,rsll897612,rs2 444728,rsl2572002,rs4274767,rs700417,rs2117794,rs831628,rsl6 836609,rs2696387,rsl 2659895,rsl795893,rsl864933,rsl2145241,rsl7236871,rs3778359, rs213658,rs976190,rs 1939876, rs2056317,rsl7719492, rsl790256, rs6805480,rs7986637, rs799466, rs4474362, rs 9468304, rs201972, rsl2343115, rs2692390,rs6442154, rs6468145, rsl6946803, rslll 92604, rs7786094,rsll709337,rsl2705851,rs5999468,rsl0766716,rsl7063 178,rs360797,rs26432 03,rsll042702,rsl509826,rs7202714,rs9911870,rsl584882,rsl539 439,rsl0040989,rs231 4664,rs7234864,rs3219171,rsl3253858,rsl401227,rsl2361312,rs3 764167,rs4247179,rsl 0762651,rsl3146859,rs3810416,rs2238655,rsl006168,rs6919346,r s9999103,rs2343072,r S1294420, rsl7384870, rs4735787, rs4882626, rsl2458817, rs9690782, rsll 611106, rsl45825 4,rsl885602,rs6801009,rs4961251,rsl060043,rsl7350771,rsl0948 109,rsl7492435,rs711 2142,rs7944887,rsl233460,rs219307,rs6425603,rs373783,rs98095 74,rs9834423,rs22684 45,rs9816597,rsl274224,rs4359587,rs6498632,rs8007191,rs35590 9,rsl0979081,rslll94 173,rs3108230,rsl7131457,rs2311587,rs6848655,rsl6971798,rsll 928508,rs7714521,rsl 2593770, rsl0785605,rs6993584,rs4885212, rsl 6927368, rs8093722,rsl2447283, rs9323049 ,rsl6908610,rsl3387809,rsl995467,rsl7123943,rs7621030,rsl685 2503,rs568675,rs8023 214, rsl2633993,rsl3175503,rs4241595, rs2269811,rs6678512,rs242097,rsl532365,rs591 875, rsll936427,rs7995015, rs6793401, rs2374710, rs2718313, rs710824 , rs501213, rsl 6910 194, rsl7682962, rslll42288, rs2583513, rs 6730679, rs704710, rs6580376, rsl7472517, rsl6 48234, rsl2468161, rs4132892, rsl3414085, rs7792939, rs4541106, rsl80690, rs7517388, rs6 826460,rsl6944789,rs7174590,rs7199329,rsl816662,rsl544986,rs l0458589,rs7337857,r s9857825,rs6426748,rsl6855141,rs7918719,rs4261230,rsl0100949 ,rs9659003,rs4616778 ,rs4645429, rsl56167,rsl2932881, rslll36516,rs6096361,rs2924667, rsl0889800, rsl6959 379, rs4810385,rsl2212557,rs6871296,rsl0161259,rsl7390084,rs70006 01,rsl2890607, rs 2961593,rsl2646225,rs9694791,rsll523185,rs7804535,rs7765003, rsl2494811,rsl3854,r sl0890401,rs7520882,rsll785512,rsl534584,rs9520249,rs2879165 ,rs2613325,rs2662234

Table 13 -25-

,rsl7095088,rsl3226538,rsl6974263,rsll073260,rs499098,rs8549 21,rs7846671,rsl7065 145, rsl040479, rs4713342, rsl2416136, rslO519194,rsl 6840202, rs2110073,rs8085561,rsl 0916983, rs4434289, rsl7400706,rs9416598, rsll977788,rsl2900044, rsl7296588,rslll308 80,rs2234211,rs8090842,rs2594995,rslll83575,rsll858540,rs203 9532,rsl7136481,rs72 22131, rs2524359, rs6664634, rs9828888,rs4681642, rs2892240,rsll 630203, rs7911815, rs9 53280, rsl2167035,rsll91296,rs9789534,rs7736675,rsl0881828,rs938082 1,rs6791611,rs 7653937, rs4075911, rsll08865, rsl7060383,rsll024333, rs7759668,rs860637, rs4691413, r s3745621, rs2165990, rs2064189, rsl655296,rsl6965312,rs730925,rsll 188385, rs7299319, rs591799,rsl7094054,rs9321481,rs4971079,rs9994520,rs4700055, rsl36225,rsl482855,r slll60611,rsl2075991,rs9314132, rsl453120,rs7608958, rs806710, rs2337012,rs4517893, rs6019284,rsl2579933,rsll217872,rs4696538, rsl0841998, rs2189669,rsl7461709, rs6771 167,rsl0163726,rs6975896,rsl020944,rsll233281,rs2623023,rsl0 072446,rsl6973930,rs 3204145,rs7813849,rsl6996440,rsl289862,rs7175732,rs838083,rs 4411272,rsl357337,rs 9713029, rsl6914095, rs9529761, rsll232921,rs2204727,rs782620, rs2465077, rsl2706628, rs7657699,rsl074876,rs6790201,rs6980194,rsl2737,rs31675,rs99 1821,rs7794016,rsl70 29013, rsl2134611, rs5751761, rs3827336,rsl467110, rs9879257,rsl0858568,rsl539826,rs 9863517,rs2444043,rs3925478,rsl7751180,rsl7229201,rsl323116, rs9958565,rsl725421, rsl7185355,rs5754086,rslO518839,rs2O7769O,rslll27924,rs47748 26,rslO518858,rslOO8 9245, rslδ 61023, rs742110,rsl3072205,rsll72111, rsll57364,rsl0132156,rsl527732, rsl7 083481, rsl3176318, rs4971536, rs7736331,rs447279, rs2810640,rs400801, rs7961477, rs47 01130, rsl7063377,rs9838540,rs223971,rs75344 l,rs3895392,rsl0058668,rs4276688, rs24 39232, rs2331140,rs4343089, rs4147308, rsl2542758, rsl7404850, rs2880919,rs9696589, rs 7809646, rs3750204,rsl7428723,rs2731842,rslll55819,rs4110220, rs7119425, rs7625829, rs974893,rs4540663,rs2622797,rsll03909,rslll50354,rs3125031, rsl902152,rs7656763, rs282390,rs3113757,rsl323487, rslll28074,rs3763640,rs3864227, rsl6914121, rs9407654 ,rsl0743514,rs4481938,rs7749355,rsl2477327,rsl334866,rs21643 64,rs4662232,rs75949 90,rs7740880,rsl2446319,rs941289,rsll863150,rs6547629,rs2185 586,rsll935607,rsl90 3998, rsll98588,rsll254686, rs7582080,rsl7492177, rsll202972, rs891884, rsl2461370, rs 11642541,rsl7743051, rslO822915, rsl3153678,rs2595258 _f rs2190183,rs2300648,rsl02224 49,rs300803,rs6416546,rs34364619,rs237134,rs2697280,rs996711 6,rsl453115,rsl24549 81, rs9594975, rs9298912, rsll009130, rs8109349, rs2035628, rs438742, rs6795255, rs24147 2, rs217076,rsll830873,rslll76716, rsl7117172, rs4656308, rsl0823305, rslO789138, rs22 61316, rs7028327,rs433477, rs4589732, rslO244209, rs6597033, rs8005078, rsl0867365, rsl 7131938, rsll055733,rsl0967512,rs4233573,rs9594184, rs6842755,rsl7252559,rsl56233, rs911185,rsl2892344,rsl0481557,rs991020,rs218498,rs989989,rs 376047,rsl491136,rsl 389375, rsl7167587,rs3121984,rs942024,rs4403119, rs6142925,rs7209493, rs7306012, rsl 871005, rsll793758, rsl 1208766, rsl017530,rs2135518,rsll025215,rs8073032,rsl845040, rsl246117,rs846814,rsl873246,rsl7563461,rs8055303,rsll862050 ,rs911532,rs333548,r slll93467,rs344797,rs2290119,rsl565735,rs7464304,rs2650128,r sl482226,rsl035688,r s2074540,rsl7326421,rsll844379,rs7786414,rs4121458,rs6494547 ,rsl ^' 6967150,rsl77745 02,rs2153856,rsl2442294,rsl7161942,rs7097330,rs894124,rsll61 9375,rsl0476597,rsl3 023914, rsl7065860, rslO894352, rslO881029, rs9896368,rs9599966,rs630018,rs6598529,r s2076194,rsl470790,rsl7124269,rsl0832492,rs2417062,rs8087817 ,rs839179,rsl048338, rsll236856,rsl7113051,rs9969426,rs7823238,rs7433351,rsl55428 6,rsl7101303,rs67597 74,rs8025407,rs422562,rsl0122509,rsl2253348,rs2365403,rs6888 233,rsl537025,rsl934 534, rsl7759504,rsll898107, rs7179693, rs 6987066, rs7005531,rsl797396, rs789404 l,rsll 001571,^6024269,^17004853,^2600193,^10012631,^12527836,^7528 241,^11744800 ,rsll007321,rs9536802,rs6137288,rs9963592,rs4737961,rsl26100 74,rsl989892,rs49397 32, rs5762185, rs2950328, rsl2819583, rslO779613, rs7660673, rsll581394,rs2618508,rs23 87658, rsl3157625, rsll221912, rsl0410884, rslll74439, rs7212406, rs7670554, rsl7835780 ,rsl2380804,rsl7458552,rs7582039,rsl564492,rsl0910196,rs4618 385,rs4467329,rsl777 8649,rs6735216,rs6816396,rsl806081,rs972444,rs7141519,rs7973 596,rs380883,rsl3207 529,rsl2370980,rs4484166,rsl838128,rs3095661,rs4867947,rsll7 49360,rsll684315,rsl 0430103,rs3808549,rs7081591,rs500416,rsl540206,rsl571566,rs7 761069,rs496627,rs29 57154, rslll61519,rsl2578981, rs8020986,rslll78820,rsll636554,rsl0966238,rs7336437 ,rsl0421714,rs2334554,rs5004102,rs434470,rsl783819,rsl261645 5,rs7581133,rsl09838 90,rs3805355,rsl2460704,rsl0167255,rsl2040431,rs7172882,rs76 24766,rs4674353,rs65

Table 13 -26-

77561, rs9967551,rs7560960,rsl 6983593, rs4778201,rs7750012,rsl0101403, rsl7183085,r sl0493762,rsl449915,rs6751498,rslll46323,rs924408,rs7518523, rs7128566,rs7008383, rsl6954586,rsl980549,rsl2455922,rsll771793,rs4641042,rsl6905 331,rs878520,rsl3269 921,rslll81750,rs7700192,rs6494387,rs2739542,rs2514999,rsl69 46428,rs4837685,rsl8 69990, rsl6832091,rs7418865, rsl321167,rs7937914, rsl7086046, rs611011,rs33947700, rs 6557482, rs681919,rsl2369213,rsl7710575, rsl7824180, rsl0094938, rsl564472, rsl291032 3,rsl0838573,rs531917,rs8049586,rs7754411,rsl7682628,rsll739 108,rsl2362105,rs339 94222,rs2863194,rs8041467,rs4856483,rsl0777991,rsl2715964,rs 2424400,rs2070951,rs 9859271, rsll881904,rsl0849946, rs2937940, rs6723291, rsl0798000, rslOlδ 6877, rs576864 3,rs8108510,rs6552604,rsl0105966,rs77725,rs8007613,rs2722872 ,rsll822105,rs720475 ,rs9968204,rsl423397,rs7374608,rs7732219,rsl7542881,rsl53678 ,rsll024688,rs261451 6,rs956119,rsl0068081,rslll39185,rs9661973,rsl2470637,rs2707 469,rs2577698,rsl716 3742,rs7559217,rs4799861,rs760900,rsll644593,rs2214087,rsll2 52126,rs2019203,rs78 14274,rs561370,rs550373,rs2617875,rs7148020,rs871387,rs80262 16,rsl2520103,rsl270 4637,rs6547924,rs6126156,rs6942184,rsl6887854,rs7016743,rsl2 439430,rs9322457,rsl 1657101, rsl2500918,rs2515132,rsl7541873, rs3829196,rs9831276,rsl7451739, rs4783678 ,rsl6851782,rs2267029,rs9706265,rs4393776,rsl346407,rs472169 5,rs8101752,rs477536 9, rs704582,rs4413596, rs2748238, rs4478563, rsl3185121,rslO416843, rs7248892, rsl6972 015,^6860727,^2742635,^4474198,^2643321,^9960307,^734767,^13 119207,^2708 82, rsl7118653, rs455567, rsll016038,rs2452333, rsl2077113,rs2746182, rs9972505,rsl02 02504,rsl2796185,rsl0944385,rs9612557,rs833904,rsl692821,rsl 0144695,rs2576776,rs 2773098,^7685444,^6705862,^7292762,^2804805,^17648791,^11729 794,^11243101 ,rsl3093535,rsl0161902,rsl406712,rs7224160,rsl0908355,rsl000 002,rs2433439,rsl270 1745,rsl002074,rsl3153782,rs2282127,rsl998612,rs615497,rs693 9216,rsl283098,rs297 598, rs2058821,rsl7135958, rs2391534,rsl3419434 ,rsl2686615, rsl317756,rsll729131, rs 1954291,rs328040,rs9839819,rs2963046,rs6966222,rs9928466,rs4 726343,rs2453648,rsl 6894117,rs2953310,rsl377980,rs6496061,rs2596741,rsl7119598,r sll98119,rsll234911, rs3752543, rs4903934, rs2795467, rsl0098153,rs3802493, rslO948190, rsl2463166, rsl 9617 21,rsl0784999,rs275940,rsll767601,rsl7027012,rs809367,rsl014 0340,rsl405648,rs742 7002,rs6946440,rsl3182221,rsl0769277,rs840958,rsl6959626,rs3 732192,rs615548,rsl9 3594,rs2399976,rsl0817160,rs3757122,rsl036529,rs4437204,rs97 5780,rsll000486,rs57 54321,rslll89244,rsll677224,rsl2403928,rsll56872,rsl323032,r s404485,rsl427050,rs 196751,rs4521985,rs8077046,rs9498029,rs7681137,rs611643,rsl2 808034,rs9703043,rs8 083056, rslO43372, rs4346967, rsl734232,rs710235, rs6601073,rs7326592,rs4754287, rs68 83784, rs7748415, rs6438963, rsl722361,rs7564924, rsl7084788,rsl7732541,rsl0761076, r s325380,rsl6984594,rs883724,rs7583698,rs2622807,rs928443,rsl 227969,rs878359,rs33 5067,rs3913547,rsl2356861,rsl90137,rs4516626,rsl537340,rs374 1595,rs33977434,rs64 89058, rsll692338,rsl3415334, rs2361697,rs9612058,rs943912, rs7017906, rsl997255,rs7 31150, rs9445517, rs4668380, rs7202092,rs4820279, rslO946213, rsll762997, rsl0748363,r sl317531,rs2122950,rs2613674,rs2137497,rs8065563,rs2030039,r s7830006,rsl2624207, rs4030862, rs6663376, rs6747239, rslO405601, rsl7286569, rs2810060, rslO426913, rs94834 54, rs677720,rs7801337,rsl2954618, rsl216433, rs9448542, rs 6552838, rslO78913, rs50372 0,rsll726534,rsl774909,rsl0950377,rs4416746,rs34910385,rs258 3084,rsl0204081,rsl7 86535, rs6491066, rs2261677,rsl861710, rs8044375, rsll893415, rsl7747058, rslO411270, r s6765863, rsl7437627, rsl76809, rsll945359, rs6006427,rs568610, rsl029559,rs7565264,r sl447536, rs559540,rsl2426768, rsll828813,rsl6977003,rs9583309,rs9559386, rs6435113 ,rs6983527,rs2271489,rs9380989,rs228221,rsl2910419,rs668966, rsl2108497,rs910151, rsl2116473,rs581405,rsll487152,rs2707997,rs7825426,rs9795910 ,rsl0468677,rsl21291 l,rsl227081,rslll21472,rs9930572,rs5999369,rs4845843, rs 697222, rs7017161, rsl68909 31, rsl878543, rsl40378, rs4499923, rslO845099, rs9402140, rslOl 99780, rsl7824297,rs535 013,rs9306501,rsl0803493,rsl654559,rs352722,rs777286,rs74159 61,rsl6884542,rsl049 9023,rsl0504358,rsl0511629,rs2417321,rsl0509645,rsl0509671,r s8745,rsl0483617,rsl 0493613, rs6494790, rsll234626, rs705316,rsl7446338, rsl6927327,rs4666483, rsll208108 ,rs4689017, rsl33738,rsl0209278,rsl7300763, rsl446512, rs7992365, rs2039386, rs431807 9,rs3807127,rs7676049,rs4978005,rsl2576089,rs6750019,rs49738 69,rs34613514,rs4529 840,rsl0521122,rs7740015,rsl0928240,rs7009086,rs7655109,rs60 49776,rsl6901622,rsl 069742,rs6885431,rsl7107133,rsll054531,rs6726768,rsl2664860, rsl2597377,rsll76498

Table 13 -27-

I,rsl71276θl,rs9683127,rs4417194,rs2859667,rs6595458,rs9233 76,rsl7294252,rs64713 83, rs6430563,rs7989524, rsl 6852030, rs2155293,rs575559,rslll75794,rs2977984,rs8271 29, rs3114834 ,rs2927600, rs2272407,rs6588505,rs9529081,rs8025377,rs6417062, rs80588 22,rs267195,rs288650,rsl0007816,rs7619760,rs7019280,rsl50728 ,rs642256,rs4624883, rs824517 ,rs4089697,rs7257553,rsl331958, rsl7034156, rs2937145, rs9402255, rs9356028, rs7013082,rs7007857,rsl946767,rs9770059,rs7223205,rsl914687, rs905909,rs6505920,r Sl7373806,rs4148152,rs7308182,rsll645617,rs7580962,rsl264845 1,rslll76078,rsl0033 229, rsl404147, rs2117327,rs2887121, rs7158518, rsl065674,rs9543433, rsll049670, rsl70 58876,rsl0937103,rs7541784,rs333165,rs9373653,rs6714356,rs64 43746,rsl397800,rs67 40220,rs2126508,rsll683006,rsl6858692,rsl0045546,rsl7058450, rs2818991,rsl993791, rsl253650,rs6437927,rs6813419,rsl461060,rs2300047,rs3218791, rs836624,rs7039161,r s662966,rsl0769706, rsl419564, rs7524875, rsl6857723,rs2709621,rs6975109,rs7669415, rs4798446,rs3748501,rsl7032230,rs298755,rs6693195,rsl2494271 ,rs801331,rsll843194 ,rs8O79764,rslO7941O8,rsl56O521,rsl7717629,rslO211241,rslO66 4O4,rs6551975,rslO13 2191,rsl442143,rsl7822102,rs228787,rs2130362,rsl984218,rsl69 19508,rsl6841279,rs3 012379, rs9538536,rsl0736837,rs3134118, rs6469915, rsl6963720,rs7842758, rs7132360, r s733830,rs2867785, rsl351924,rsl7765605,rs9674557, rsl2517607,rs7527610, rsl82411, r sll242001,rs347250,rs2320619,rs2479373, rsl0081385, rsl 6884434, rs4721705, rsl010416 5,rs7236977,rs956255,rsl340396 _f rsl758918,rslll73081,rs4673171,rs35504261,rsl0979 386, rs7945769, rs6732625,rs7975705, rs6955319,rs4681992, rs6748332, rsl7837764, rslOl 89498,rs4642242,rs3919592,rsl812571,rs6727506,rsl6864944,rsl 3133320,rsll678557,r S12105764, rsl86884, rsl0935347,rslll59536,rs7927859,rsl354736, rs7748599, rs3797184 ,rsl0895956,rs9296193,rs4726441,rs4789753,rs4862250,rs253314 6,rsl0424345,rs71580 42, rsl7118727,rsl420916,rs4286111, rs636753,rs3761082, rs9515672, rsl 674914, rs26093 55,rsl572379,rs4658015,rsll078555,rs6661170,rs9864349,rsl092 3467,rs2127211,rsl24 5576, rsl0502625,rsl2677755, rslll27330,rs6483062,rs9862718, rs7810045,rsl07697 l,rs 972684, rs2510356,rsl0502857,rsl723573,rs240154, rsl886405, rslδ 66370, rslOl 67155, rs 9650165,rs7098436,rsl3252176,rs3735172,rs6976275,rs9968411,r s9961760,rs9304456,r S17074374, rs8729,rsl0936953,rs4735413, rs4021274, rsl 693251, rs3124736, rsl2632233, r s9389717, rs420511,rs4977716, rs2178353,rs7733752,rs7655559,rs2401408, rs379975, rsl 441914, rs8012000,rsl7087636,rsl7681592, rs9377800,rs2476953, rs7981007, rsl2666192, rsl392998,rsl54756,rs7769298, rs7766973, rsl6890234, rs502794, rs9308152, rs6673366,r Sl2191119,rs6128850,rs9341349,rs4750994,rs7547448,rs9881120, rs7842755,rs8096805, rsl545298,rsl7287295,rs2921945,rsl2663742,rs8072580,rs443283 7,rs700658,rs7380792 ,rs573156,rs2575965,rsll038914,rsl645410, rsl 6914063, rs4718885, rsl820416, rs241877 0,rsl7163934,rsl7807445,rsl0008,rs2364848,rslll27129,rs96668 78,rs6432765,rs67329 00,rs4876776,rsl7503508,rs7035879,rsl320011,rs4474582,rs2860 099,rs9327577,rsl667 284,rsl7466543,rs4741017,rsl572768,rs7247641,rs6708411,rs439 2770,rs6466190,rsl02 12507, rs2340479, rs632098,rs7077271,rsl7170187, rsl2418383, rs621425,rs7185429,rsl5

79292,rsl399222,rs7154709,rsl0792843,rsl0749099,rs2914255 ,rsl539388,rsl0977210,r Slll04497,rs6127859,rsl856638,rsl0521014,rsl2599248,rsl68253 40,rsl0893232,rs4826 92, rsl81130,rsl400151,rsl0495693, rs2365555,rs2195499, rslO490098, rs2862185, rs7237 05, rslO496275, rsl7023794, rsl2328314,rsl0496775, rs2171107,rs2381759,rs222811,rs37 69956, rslO497311, rs312918,rslO497442, rs9287993, rs6743733, rs3771317,rsl0497730, rs 801340,rsl0497812, rs2159000,rs7609511, rs2216782, rsl 954267, rs2206920,rsl346655, rs 2868161,rs3787158,rsl0482849,rs3751286,rs2406889,rs207482,rs 218623,rs720621,rs73

8996,rsl2124561,rsl0510437,rs949665,rsl0510493,rsl0489247 ,rs952621,rs488273,rs71 9775, rs4131575, rsl7398137, rsl0511199,rsl673887,rs2332739,rsl872239,rsl6854819, rs 10513551, rs6763377, rs9290468, rs6661715, rsl805609,rsl0513857,rs6844834, rs230629,r s3796795, rsll58230,rs7682914, rs2337717,rsl946966, rs480148, rs904132, rsl0517501,rs 7700012, rsl031536,rsl584568,rs2367430, rsl459061, rslO518461, rs2175458, rs358310,rs 2635429,rsl0494768,rsl0519917,rs996834,rsl7035816,rsl603631, rsll50461,rsl0520899 ,rs7380077,rs595285,rs316763,rsl0514880,rsl583017,rs265005,r s2184919,rsl7507502, rslO519913,rslO491266, rsl0520083,rs830532,rs7729828,rsl824936, rsl394608, rsl70525 86,rsl3186057,rs9313525,rsl951923,rsl6882184,rsl233493,rs280 302,rs9382239,rsl419 088,rsl0485282,rs485963,rsl220444,rsl030428,rsl972474,rsl049 9101,rs3798853,rs247 5861,rs921298,rsl0485203,rsl0274998,rs36845,rsll78363,rsl026 9473,rsl0485975,rs21

Table 13 -28-

88846, rsl476991, rs4636106, rsl7150810, rs2634083, rsl2532467, rsl320589, rslO487255, r sl0487221, rs3863745, rs715205,rs4551267, rsl419970, rsl317057,rs2365281,rsl0504197, rs755223,rsl0504398, rsl866740,rsl0504551,rs7839360,rsl805875,rsl415880, rs2853255 ,rs3105186,rsl0508373,rs9297357,rs4259393, rsl0505164,rs611292,rs7818548, rsl05055 44, rs710616,rs2467193, rsl0491739, rs4961655, rsl0511716,rsl316774,rs2383784,rsl691 0870, rs4129050, rs6679037,rs2393011,rsl0996304,rs956168,rsl990482, rs7973206, rs735 8683,rs2354354,rs8038697,rs2252153,rs7244910,rs6516595,rs677 5424,rsl579020,rs963 028,rsl849342,rs4432863,rsl425195,rs2964686,rs2155220,rsl050 1469,rs302656,rs6994 384,rs7124287,rs2843576,rsl327254,rs922264,rs7875761,rs72779 52,rs2825779,rs28269 36,rsl7759053,rs9305376,rs2211813,rs2833537,rs844986,rs46935 3,rs6586344,rsl32238 88,rsll585686,rsl733865,rsl0183453,rs626360,rs8015004,rs9575 863,rs6926831,rsl981 881,rsl2703791,rsll968517,rs2159679,rs2808022,rsll75149,rsll 076684,rsll844425,rs 9851825, rs3925045, rsl7786823, rs6494518, rsl7537411, rsl6963773,rs4871506, rsl702998 8, rs8012292,rs6458307, rsll829539,rs7935712, rslll 65939, rsl2315961,rs4715392, rsll5 82843, rs4576739, rsll 628074, rs386804 l,rsl0091346, rsl381674,rs6499813, rsl7115583, r s322764, rs4734094, rs7959932, rs4292660, rs6580314,rs2462956, rs9639329,rsll776669, r s7633396, rsl7352658,rs957567,rs4862419, rs3813712, rs2275312,rs3120956,rs6531698,r sll925251,rs929837,rsl874805,rs2175594,rsl0019897,rs4592762, rsl7141353,rs4424782 ,rsl335017,rs303009,rs706440, rs245954, rs6966038, rs3789543, rs4935368, rs2565085, rs 16943064, rs6839768, rsl2795435, rs2282521,rs9926192,rs6068277,rs7681728, rsl7506653 ,rsll612273,rs843287,rs2055738,rsl7789523,rs857228,rs2707797 ,rs7427760,rs282708, rsl6902090,rs4784227, rslO224870, rslll06425,rs565349, rsl521588,rs9868067, rs220687 ,rsl001408,rsl7132406,rs940274,rs8051575,rs4627141,rsl941361 ,rsl0125103,rs746436 0,rs9849573, rs4770864, rs307378,rsl711655, rsl933320,rs7231717,rsl0506837,rslll741 91,rsl0842058,rsl51181,rs275344,rsl7007241,rs7135847,rs21130 58,rs454583,rsl51783 ,rsl0885343,rs2706984,rsl0492295, rsl7721806,rsl 6936056, rsl7054675, rsl7517151,rs6 861101,rsl2541837,rsl7370889,rsl7109462,rsl2632844,rs4617520 ,rsl0047895,rs758688 5,rs7730936,rs789517,rsl7017247,rsl99494,rs7925066,rsl094515 4,rs3759213,rs795273 9,rs6587156,rsll026206,rs2243512,rsl7164113,rs7514330,rs6725 545,rs496344,rsll950 065,rs7553478,rsl037925,rs6506088,rs6821561,rs8055305,rs7950 647,rsl075467,rsll25 841,rs2960920,rs6537561,rsl019664,rsl977328,rs2075397,rs6109 425,rsl420929,rs2701 105,rs811689,rsl3166147,rs248155,rsl3049373,rslll45671,rs766 9074,rs6097438,rs485 1201,rs2391236,rs9299296,rs884033,rs4445,rsl551656,rs6656688 ,rs4140806,rs2511,rs 4763222, rs4672338, rsl370587,rsl2918149, rs4147807, rsl3076104, rs6419917, rs7204525, rs9348440,rs3748470,rs2535581,rsll35172,rsll018855,rs4692741 ,rsll635298,rs936032 2,rs2212655,rs2304387,rsl3010889,rs2943570,rs7994634,rs43705 34,rs4980007,rsl4330 10, rsl7084606, rsl638742,rs9315215,rsl0849124, rs306540,rs9547075, rsl3246026, rs232 3442,rs4800019,rs920459,rsl333509,rs3933838,rsl7353212,rs233 3184,rs4898659,rs911 627,rs6844246,rsl0492434,rsl733741,rsl7413044,rsl0996895,rs7 621998,rs2322168,rs5 12660,rslll65874,rs977003,rs903173,rs7776307,rsl7097879,rs67 48662,rs6560284,rsl6 839731, rs2303732,rs4888535, rsl3184913, rsl0819510,rsl543973, rs4239421,rs2901761, r s2482838,rslll50610,rs2909968,rsl567101,rs2429191,rs2696114, rs2504977,rsl7516786 ,rs9954574,rsl7006203,rs2149088,rs4263587,rs224608,rsl086310 1,rs4147134,rsl38917 l,rs2049277, rs7688653, rsl6875106,rs4260511, rsl2986736, rsll55456, rs9540572, rsl311 2049,rsl760672,rs2150484,rs923408,rs916171,rsl0988944,rsl020 0963,rsl7014760,rsl0 740169,rsllll451,rs6837314,rs934056,rsl7084772,rs3104449,rsl 0937531,rsl7197854,r s808152,rs7568190,rs6693453,rsl3225806,rs376478,rsl2447371,r s8096984,rs7140576,r Sl0739625,rs6672282,rsl2581131,rs9837956,rs9810994,rs2316030 ,rsl0760446,rs764160 8,rsl0045186,rs385089,rs9839877,rsll617038,rs4334868,rs46596 13,rs8042778,rs49011 34, rsl834088, rs 6828252, rsl271344 I,rs7920125, rsl7182053, rs268073, rs 913005, rs 69066 22, rs2196483, rsl0508027, rslO917152, rsl 6945353, rs4807514, rsl214196, rs3783257, rsl 9 9689,rs6717561,rsl283142,rs2250775,rsl0743718,rs2896439,rsl5 87998,rsl498444,rsl0 508087, rs4574375, rs8013622,rs6820244, rs3940907, rsl0153556,rs2968323,rsll061407, r s7684094,rsl2612543,rs7945387,rsll099754,rs2804528,rs9821929 ,rs2326566,rs7555016 ,rs4984731,rs4376484,rsl0413556 _f rs916048,rsl3174206,rsl548128,rsl981760,rs350799 ,rs655605,rs4905166, rsl936393,rs575902,rs7787974, rsl950937,rs4981696, rsll563233, rsl7321328,rsl0431725,rs2103001,rsl0053628,rs6685383,rsl0172 481,rs6549049,rsl903

Table 13 -29-

222,rs215095,rsl521522,rs4834476,rsl256056,rs6591555,rsl2 520714,rsl6916109,rsl25 98911,rs4488515,rsl7561453,rs6672844,rs4541797,rs7793039,rsl 059840,rsl7819991,rs 6729653, rs2992064,rsl363759,rs6985700,rsl2504607, rsll070567,rs4945555, rsl409145, rs760855,rsll847326,rs2346216, rs317522,rs6746997, rsl7039902,rslll58795, rs7210042 ,rs4802998,rsl0000033,rsll346,rs8031759,rs8076398,rs7556747, rsl7677599,rsl727854 3,rs7841423,rs3107082,rs851681,rsl0146433,rs7007331,rs686438 1,rsll065322,rs75300 21,rs4434338,rs6710388,rsl0040650,rs9287482,rs6893466,rs9492 057,rs6135115,rsl714 2507, rsll761539, rs6066223, rs6650151, rs7834775, rs7106567, rs4548120, rsll080118, rs8 074800, rsl7641065, rs2767000, rs4761998, rs8073615,rsl2329336, rs2996405, rsl0914117, rs2909109,rs2442110,rsl002194,rsl0767871,rs767686,rsl0144064 ,rs4948776,rs2709336 ,rs6507779,rs4936513, rs2387137, rsl54034, rsl340682,rs854505, rs486416, rs796555, rs7 651539, rsl230103,rsl7539845, rs 6913088, rs772424, rs7593062, rsl6852842, rsll846818 ,r sl7191093, rslO460317, rs4846216, rs7256469, rs379192,rsl3133619,rsl7095553,rs379255 8,rsl6916460,rs6520053,rsl6867780,rs2170092,rsll207026,rs484 0673,rs7578692,rsl02 56786, rs2677051,rs2178683,rsl930206,rsl050488,rsl65032,rsl490695, rsl0072090,rsl3 174713,rs6042145,rsl520942,rsll211200,rs2294831,rs6563130,rs 2879291,rsl3074606,r s354138,rsll219172,rs6447209,rsll04570,rsll78163,rs3110116,r s4434373,rs9543234,r Sl0772528,rs2090479,rsl0932382,rs6838029,rs6493363,rsl913939 ,rs6449003,rsl014859 5,rsl0481503,rs6581847,rs4707851,rs3804481,rs4872207,rsl5313 27,rsl0518980,rs2028 119,rsl0238963,rsl3402784,rs4887164,rs7516204,rsl0081495,rsl 452485,rsl3125058,rs 6879497, rsl373661,rs7205632,rsl0179053, rs6493470, rs546271, rs9869020, rs947555, rs7 81200, rsl507662,rs4945362, rs7226064,rs4417230, rsl924022, rsl2980596,rs666930,rs60 60442,rsl0788072,rsl531541,rs7555976,rs9289889,rsl0793169,rs ll042832,rs6993429,r sl7074473,rs6948482,rsl517036,rs7356805,rsl0823467,rsll83335 2,rsl573707,rsl99054 3, rslO43291, rs9479330, rs773393,rs4916107, rsl2127053,rsll799558, rs2680967,rs71386 83,rs3853477,rsl7361504,rsll239629,rsl7248982,rs6712017,rs60 56536,rsl6882596,rsl 6996744, rslll03390,rs961873,rsl2693276, rsll635690,rs4989273, rslO179648, rs7088058 ,rs735343, rs510734,rs4905366, rs2046159, rs7632573,rs638527,rs7338868, rs9866824,rs 1992248,rsl6836191,rs8037065,rs9920389,rs2405271,rs2204204,r sl0756712,rs7502667, rs7227145,rsl041327,rs5004584,rs7972845,rs7091246,rs7445360, rs276402,rs6957986,r S4480940,rs787295,rsll593916,rs4558646,rsl53039,rsl452261,rs l2264514,rsl948578,r sll652429,rs4358083,rsll576264,rsl497835, rs3849220, rslO860857, rsl592051,rsl69947 79, rs6506698,rs570660,rs2505803,rs4822154, rs9359655, rs4788933, rs6656726, rslO9335 54, rs7956106, rsl0500373,rs488672, rs9544109, rs326614, rs7553582,rsl2681298,rslll57 655,rs260284,rs3732771,rs4290927,rsl487718,rs4344930,rs80664 97,rs6543324,rs71307 95,rsl2720218,rslll78149,rs4632483,rs8032572,rsl7326999,rs48 1835,rsl2904777,rs37 54507, rs9573321,rs9451127, rs766757, rs978844, rs6437543, rs6938454,rsll778905,rs932 410,rsl7699495,rsl0939161,rs4723808,rs7686651,rs7104461,rs82 9412,rs7773095,rsl08 57787, rs3118040,rs4490927, rs6565136, rs935454, rs4264521, rsllO77314 , rsll 677822, rsl 0998476,rs2599737,rs4707628,rsl0913339,rsll642591,rsl724763, rsl244869,rsl0950139 ,rsll088206,rs2464803,rs6829651,rsll863489,rsl893010,rs99910 39,rs954765,rsl01949 21,rsll259365,rsl7084751,rs6688672,rs2283646,rs9810659,rsl08 64554,rs554727,rs881 236, rsl7759598,rs4263966,rs6773873,rs8048037, rs6928074,rs7199857, rs6484218, rs492 943,rs3790458,rs203846,rsl0807437,rs4663834,rsl0248128,rs781 6410,rs2164344,rs488 0251, rsl946040, rs7302674, rsll635505, rs935331, rslO857512, rs423904 , rs7932186, rs775 3825, rs7630875, rs9600257, rs7821929, rs2012168, rsll849690, rsl70040, rsll865476, rs23 04071, rsl510266,rsl0960660,rs6112244, rsl 6965266, rsl7603782,rs8013004,rs3171985, r sl2577157,rs4961338,rs942222,rs675592,rsl893660,rs583970,rsl 374230,rs6852803,rsl 7056627, rsl0879508,rs614367, rsl7724734,rsl0883649, rsl0878858,rs2432055, rs2530377 ,rsl811817,rsl7020044,rs6946578,rs7916445,rslll46874,rsl2135 331,rsl994312,rsl697 9427 ,rs7313490, rs3890807, rsl7825125, rsl475720, rs8124241, rs3829156, rs280873, rs429 224,rs9467445,rs7952767,rs327110,rsl0803204,rsl7237318,rsl83 0335,rs7083992,rsl25 73872, rsl0258739,rsl0844826, rs4855535, rsl36457, rs2862058, rs6535763, rsl6835227, rs 757844,rs2994630,rs917066,rs6930859,rs6846248,rs3792935,rs72 16235,rslll9211,rsl6 867332,rsl0521244,rsl703515,rs4083872,rs2404482,rs770533,rs4 26101,rs242247,rs781 429,rsl012780,rsl7033999,rsl0471666,rs4313795,rsl0828686,rs3 744227,rs2469760,rs7 089521,rs3909548,rsl7225878,rs4530248,rs4703987,rs256094,rs3 766623,rs353952,rs99

Table 13 -30-

13546, rsl530664,rsl 1885927, rs39896, rsl7011020, rsl953399, rs213138, rsl7240713, rslδ 897859,rs9615801,rs4407079,rs2127955,rs7302916,rs2003279,rs6 02688,rs9997601,rs49 72795,rsl2308822,rsl3325518,rsl0748887,rs7864609,rsl7509584, rsl7475645,rs7501838 ,rsl7034569,rsl0145743, rs897632, rs528455,rs415024, rs2280743, rslll 90892, rs4751376 ,rs820172,rs7315607,rsl6962863,rs2863801,rs2982292,rs864496, rs6494973,rsl2476173 ,rsl7727045,rsl7434403,rsl81585,rs3901898,rs6433315,rsl25352 12,rs4073291,rs6967, rsl6842071,rsl92046,rs3751151,rs7465333,rsl0751722,rsl372538 ,rsll658131,rs952216 8, rs768071,rsl7631940,rsl0243165, rsl 6914725, rs4503862, rs34674704, rsl2505249, rs77 53432, rs4661202, rsl3273049, rs6603155,rsl7326194, rsl0028962,rsl398792,rs942881, rs 4546701,rsll688662,rsl0004753,rsl007026,rs8046240,rsl2363932 ,rsl019808,rsl003862 5, rs4928188, rs2501557,rs8022988, rs549914, rs4473858, rs2594794,rsl390754,rsl428859 ,rs4240436,rsll771438,rs337558,rsl0899121,rsll676858,rsl2528 422,rs4877693,rs6733 558, rs30208,rsl0839756,rs9827734,rsl0196832,rs6535543,rsl481952, rsl7086183, rs602 3096, rsl433501, rs4887835,rs2694158, rs2406898, rsllll6393,rs235122,rslll0074,rsl56 0332, rs4628581, rsl2060726,rs6536514,rsl0179214,rs4720429,rs735837,rs2038926 ,rs61 7127,rs2007786,rs6469434,rsl735412,rsl7148591,rsll755864,rsl 0746932,rsl049457,rs 7626725, rsl426550, rs4660278, rsl328860, rs34014631, rs3010071,rsll078031,rs362842,r s959077,rsl947555,rs6808920,rs885792,rs4459076,rs644041,rs77 33361,rs9510093,rs92 58220,rsl7138327,rsl0913522,rs2293525,rs636820,rs7186088,rsl l726200,rs4785346,rs 6477191, rs640908, rs7983420, rsl031120,rs7502703,rsll627426,rs9511031,rs6469136, rs 12530182, rs2600584,rs9820678,rsl943999, rs4720035, rs7760017, rsll903741, rs6510101, rsl0176943,rsl384338,rs8071494,rs6080991,rsl7233214,rs252847 2,rs2922506,rs716280 3,rsl600666,rs2129646,rs2781346,rsl2459839,rslll5711,rs69187 77,rs4681659,rs66559 40,rsl0887632,rsl480000, rs6766252, rsl0801982,rs2000000,rs7558557,rsll78199,rs957 2582, rs9320010,rs7173954, rs665036,rsl6864539, rsl2607965, rs2288862, rslll06087, rsl 0773005, rs7694206, rs8124887,rsl2656373,rs7744325, rs583241,rsl6833343, rs8096263, r sl2586107, rslll95417, rsl942583,rsl71545, rs323947, rs7935561, rslδ 62174, rsll68458,r s7227098,rs2191736,rs4566357,rsl0849329, rs4267414, rsl7156276, rsl3149932, rs667032 2,rsl0476307,rs7011792,rs4789694,rs2059357,rs7660223,rs68467 60,rs2884308,rs48366 72,rsl7064905,rs8007981,rsl769813,rsl571484,rs6898454,rs7983 415,rs6503954,rsl538 416,rsl2986656,rsll071737,rslll36221,rsl859795,rsl0956197,rs ll250964,rsl995916,r s6849760, rs3739827,rs271031,rs745661, rs38523,rsl500662,rsl7760337, rs7895754, rsl4 39316,rsl350986,rs6075070,rs9624808,rs2109862,rsll692547,rsl l66206,rsl0734012,rs 1998906,rslll26953,rsl7120515,rsl2909663,rsl224760,rsl719124 6,rs2054857,rs750858 4,rs9422545,rs3797714,rs669867,rs9987318,rsl989877,rs2991370 ,rsl6974823,rs499140 0,rsl7027716,rsll776021, rs276623, rs9608799,rsl0005551,rs9582124,rsl375832,rsl607 664, rsl836630,rs7740137, rslO474554, rsl2951315,rsl980518,rs354842, rs6802422,rs939 0357, rslll21828,rs7813318,rsll079501,rs4932709, rsl766360,rsl3320647,rsl7569530,r sl0520211,rsl976053,rs2024046,rs4347412,rs9830271,rs611905,r s8013827,rsl6952975, rs6746683, rsl6888118,rsl3295519,rsl0985486, rs2039096,rs4751990, rs749529, rs709611 3,rsl871087,rs2103105,rs7574157,rs4952528,rs786412,rsl019696 3,rsl420183,rs634785 ,rs969934,rsl0520166,rsl0496390,rsl375034,rs3115346,rsl43768 9,rsl568186,rs757550 6, rs7555566,rsl485854, rsl0497340,rsll 93625, rs919682,rs296797, rs5742909,rs6716615 ,rs2251129,rs4674305, rs9646874, rs4145724, rs9288635, rs4845390, rs979332, rs6053520, rsl2481462,rs879064,rs3850528,rs6130130,rs2208048,rs6122682, rs964732,rs2070151,r s2834484,rs2836633,rs2837780,rs2239575,rs6519411,rsl933077,r s713717,rs6443100,rs 471569, rs3821394,rs711702,rsl7027581,rs2421987,rsl0510755,rsl913157 ,rslll30920,r S9309736,rs9309792,rslll28072,rsl7804223,rsl0489307, rs6775136,rs7340748, rs764362 9, rs9290747, rslO22247, rs7439266, rs7671055, rs2570100,rsl979894, rsl331126,rs766832 2, rsl814814, rsll726196,rs6836119,rs4956396, rs6820696,rsl993109,rs6813964,rsl0520 504,rs2494286,rs6700051,rs955323,rsl0520903,rs7737188,rs6861 906,rsl0491482,rs381 5919,rs977877,rs601429,rs2972843,rsl008661,rsl494590,rsl0519 348,rsl7390432,rs932 7261, rsl0519976,rs42265,rsl074840,rsl0491291, rsl229732,rsl0491308, rsll22081,rs91 8407, rs9328087,rs688176,rs2208870,rs209800,rs9283925,rs2754777,rs l028311, rsl 6873 781,rs243119,rsl525354,rs2622277,rsl0485244,rs989191,rsl2184 324,rs200808,rsl7793 103,rs35689029,rs2327661,rs2486414,rs4074888,rs2068638,rs379 65,rs2906552,rsl2542 06, rsl0486615, rs3779127, rsl852611,rs2189817,rsl2742885, rs4330872, rs2074755,rsl04

Table 13 -31-

99847,rs719336,rs354046,rsl0503186,rs2688266,rsl0503257,r s4873102,rsl6916961,rsl 0504319,rsl0504792,rsl0504931,rs6468783,rsl587770,rsl905760, rsl0960945,rsl916310 ,rs7872081,rsl054657, rs2298312,rs7905908,rs4742834, rsl0512385,rs9644902, rsll7891 58,rs7849611,rs3747843,rsl2352132,rsl536861,rsl0491512,rsl08 29261,rs3808909,rsl0 508758, rsl0508788,rs528095,rs6425431, rs6685804 , rs7550249, rs6686207, rsl912607, rsl 0508987, rs2815623,rs2588976, rs7920422, rsl0509155,rs2658785,rs631318,rs4758900, rs 442149,rs4288931,rslll88575,rsl0509709,rs2112810,rsl0509768, rsl362441,rs628419,r s7235772,rs4131643,rs584811,rsl0493102,rs4389300,rs6731095,r s714691,rs6040843,rs 1894128,rsl7497182,rs5753625,rs6772333,rs720092,rs4515097,rs 4687417,rs4416546,rs 7684847,rsl2224036,rsl491332,rs2467285,rsl63456,rs2136726,rs 6580138,rs6883493,rs 490192, rsl0492935, rs645436, rs669754,rsl0493142, rs7795231, rs7832708,rs6995671,rs4 323574, rs649398, rs4816958, rs4817011, rs23743, rsl2626719,rs2832594,rs7281899,rs651 7297, rs2898317, rs2257130, rsl0488742, rs2838019,rs2839418, rsl62386, rs7277792,rs235 385,rs3863298,rsl7369792,rs4467688,rs9352417,rs2510763,rsl08 06988,rs4969381,rsl8 26546,rsl535759,rsl0995750,rs9321142,rs4735907,rs3006496,rs7 06133,rsl2628791,rsl 6976728,rs3758521,rsll065716,rs975537,rs7316135,rsl2152734,r sl0114348,rs2721897, rs7337310,rs7139704,rs4727512,rs2302248,rsl0814888, rslO894028, rs2720044, rsl 68704 25,rs2889630,rsll260720,rs463426,rs9330317,rsl7161889,rs7723 509,rs925350,rsl7081 694,rs4238244,rsl712983,rs9590106,rsl7396303,rs236711,rs4767 068,rs6584453,rsllll 7671,rsll886905,rsl2188792,rs8081537,rs365909,rs6107896,rsl0 131923,rsl690685,rs2 855939, rs6545831,rsl76549, rs2896961, rs7176023, rsl425155,rsl6888754,rs7305861, rs2 418877, rs4940307, rsl546013, rs3846688, rs7953150, rsl7031287, rs6976658, rs453488, rs7 952054, rs4350001,rs696770,rs641943, rs3004068,rsl415981, rs7928717, rs8045739,rs674 2958, rs786771,rs949025, rs266655,rsl764577, rsl608134,rs2272495, rs7920368, rs701649 7,rs7849566,rsll059140,rsl0900403,rsl795859,rsl2141773,rs666 3232,rs6665419,rs647 9376,rsl2679977,rs734518,rsl953844,rs3740279,rsl0134704,rsl4 56168,rsl34006,rs290 4382,rs7316454,rs4370127,rs7229071,rs8073040,rsl6963406,rsl0 793047,rs9379851,rs4 524773, rs827593,rs3760843,rs26893, rs2861712, rs8006959,rsl2580729,rs9792459, rs778 7226,rsl799986,rsl689595,rs4406493,rsl482785,rs4600976,rs286 37978,rsl2646249,rs9 12748, rs6845525,rs2925763, rs2111639, rs7791660, rs4671070, rs759082,rsl7688269, rslO 817570,rsl0753858,rsll231741,rs2887827,rs346146,rs2764862,rs l7066528,rsl2565728, rs6904744,rsl0506571,rsl2464664,rsl360385,rs6668687,rsl23435 2,rsl7398599,rsl6953 766,rsl2145484,rs6743167,rs327852,rsl0771281,rs2202159,rs607 6059,rsl2439689,rs99 41935,rs2389803,rs723940,rs6596727,rs6784820,rs748806,rs8087 603,rs3909851,rs4814 489,rsl68681,rs6678964,rsl3225921,rsl2597905,rslll98619,rs93 18163,rsl0243991,rsl 1129399, rsll768465, rs7028822,rsl7637193, rs3761710,rsl3330832,rs9650572,rs216562, rs2352446,rs6940831,rsll033767,rsl0801772,rs7900579,rs205446 8,rs8003491,rs770890 2, rs7997216, rs6889573,rs7311343, rs2764809,rs4562360, rsl 6869888, rs7007407, rslO151 886,rs813676,rs7431357,rs4479875,rs734016,rsl0887363,rs94495 89,rsll688203,rs4791 759, rs8049302, rsl0507187, rs8027868,rs9451243, rs7248231, rs6554329, rslO492252, rslO 507235, rs4422355, rs9555895,rsl2867513,rsl0789627, rsl274326, rs9840557, rs9535858,r ξ7829124,rsl2545580,rs3906185,rs6121201,rs6433461,rsl042555 2,rs3218256,rsl549949 ,rsll05616,rsl429117,rs2327936,rs987193,rs2046362,rs4456578, rs329271,rs6747431,r si 997059, rs7774822, rsll245515, rs4653526, rsl2701937, rsl485197, rs2541762, rsl514897 ,rs454693, rs750582,rsl7150205,rsl0840455, rs2807651, rsll254091,rs4146178, rs485510 7,rslll51327,rs3864925,rs2404986,rs4517302,rs7444022,rs42722 78,rsll99735,rsll070 854,rs2953970,rsl2538002,rs271962,rs2142619,rsl7073448,rs203 6951,rs885374,rsl711 4808, rs3923815,rsl7161698, rsll669584,rsl017529,rs7977687, rs3791815, rs534150, rs22 06860,rs7499404,rsl2410895,rs6917021,rs8079632,rsl366814,rs4 282169,rs473756,rs67 85834, rsl2619068, rs6909681,rs2157743,rsl2206695,rs6651076,rs91166, rsl 6970035, rs2 80808 l,rsl528022,rsl0507419, rsll629796, rsl2594168, rs4851776, rs8138982, rslO215935 ,rsl2490417, rs2673359,rsll062006,rs6736303,rsl2620544, rsl 6991332, rs2184010, rs205 9503,rs359295,rs8069850,rs9315801,rs508733,rs720824,rs930641 9,rsl0984020,rs64651 I,rs4300537, rs2151436, rs2710175,rs4363548, rsll80379,rs768325, rs2388139,rsll96745 3,rs7254267,rs4389875,rsll064410,rsl509683,rsl013571,rs21187 06,rsl7525,rsl057793 ,rs4796052, rs8075374,rs744695, rsl2478085, rs6055513,rsl0791373, rsl2492635, rs29250 41,rs466223,rs2730471,rs7225431,rsl318128,rs4945149,rsll6317 12,rsl865840,rsl7118

Table 13 -32-

865,rs9547920,rsl455913,rsl7050727,rsl0207406,rs6599319,r s4968679,rs3138139,rsl3 37645, rs233170,rs895957, rs7604877, rslO734097, rs6573298, rslll 69954, rs 925967 , rs899 919, rs9678598,rs9431660, rs2155759,rsll097722,rsl6893570,rsll740851, rsl59066,rs23 39627, rsll083186,rsl2050257,rsl0814266,rsl0492592, rsl7475584 ,rs2817798, rs2630707 ,rsl332772,rs7182283,rsl52185,rs2652853,rsl2895070, rs7259554,rsl7113911, rslO8871 75,rs7091959,rsl952650,rs2817438,rsl343804,rs7615151,rs67477 45,rsl2884744,rsl089 1245, rsl2339235,rsl458332,rsl0803657,rs6067511,rsl95934,rs7521800 ,rsl331601, rs52 3781,rs7103374,rsl7828651,rs6494673,rs927494,rsl0507874,rs65 78446,rsl0100213,rsl 7311264, rs4714739, rsl879240,rsll700279, rs7554730, rs565,rs3771316, rsll842992, rs49 75166,rsl0800350,rsll732312,rs2057518,rs3751178,rsl844261,rs 5752764,rs360188,rsl 326426, rs3025299,rsl0826516,rsll227234,rsl2497801, rs4737394,rs4505988, rs7257051, rsllθlllθl,rsl 6951881, rs39550,rs4920630, rsl49565, rs7749435, rs7324123, rsl0853782, rs6481576,rs7526967,rs9875094,rs2306568,rs4795519,rsl7608466 ,rs572846,rs6036939, rsl0152363,rs779954 I,rs4008155, rs9826812, rs7588424,rsl6890074,rs893840,rsl077912 3, rs6758538,rs2787508,rs4982176, rs5750871,rs2946645, rs2029211, rsl7131710, rs69753 60,rs6460302,rs640720,rslll07789,rs4522807,rs2916214,rs78326 79,rs2035290,rs26721 6,rs257868,rs2724706,rs773319,rs9554197,rsl7120763,rs4900208 ,rsl0923636,rs768108 2,rs6662867,rs4856663,rs962688,rs9655302,rsl6876585,rsl09455 83,rs5753394,rsll069 732,rsl7032968,rs852397,rs810517,rs8188245,rs8058400,rs22869 60,rs6656570,rs94976 32,rs2067040,rs4077968,rs9807249,rsl300253,rsl563108,rs65642 55,rs880375,rs749627 9,rs9354154,rsl2713044,rs9353992,rs2818044,rs9445639,rs73215 08,rsl7200484,rsl296 795,rs7448884,rsl590392,rsl370526,rs7869562,rs6142474,rs4749 121,rs7920861,rsll01 1420, rsl685354,rs4790850, rs4890167, rsl353058,rsl551855,rs7561273,rsll250624,rs20 77024, rslO814501, rsl904995, rsl2277533,rs3825932,rsl0793981, rs6832640,rs9308300,r s2287996, rs2734990, rsl769617, rs7674517, rs5766004, rs4554907, rs974542, rsll 630546, r sl563295,rs4077822, rs6910158,rs6692148, rs6485554, rsl7578596,rslll41357, rs7846693 ,rs908678, rs3755702,rsl378315,rsl6860627, rsl0085109,rs3790857, rsll669811,rsllll9 748, rs6121620,rsll599194, rsll 619518, rsl0854233,rsl7139045, rslll00883,rs2491101, r sl6884579,rsl2288111,rsl477848,rsl7825174,rsl7026705,rsl7178 433,rs343388,rs28069 26,rs6031477,rs7700334,rs2281731,rs2423273,rs7735132,rs28517 6,rs8014382,rsl71290 86,rsll083982,rs4725898,rs9920854,rs6723148,rs2662826,rsl330 1354,rsl320722,rsl71 62316,rs3794521,rsl574462,rsl254274,rs9847223,rsl868123,rs61 18819,rslll37410,rsl 6857648, rs9323411, rs4643693, rs2169843, rs2807304 , rs7142819, rs3826529, rs2700062, rs 10483775, rs815452,rsl0483789, rs2152652, rsl432095, rs2907289,rs763075, rs2925337, rs 6424275,rsl2524863,rs6813843,rs8108861,rsl6891620,rsl7422137 ,rs6042365,rs9395504 ,rs7094058,rsl482672,rs6900844,rs847330,rsl986507,rsl0894845 ,rsl6883273,rs599730 l,rs6443262,rs7930,rs237325,rs657355,rsll089264,rsl619327,rs 6061636,rs6689415,rs 12703182, rs9957192,rsl0892272,rs4836041,rs9933497, rs519113,rs6694102, rsl2604562, rs2339800,rs7581977,rsl0226143,rsl6921260,rs7709645,rsl21143 11,rs7513147,rs23105 l,rsl2531020,rsl492984, rs2013565,rs4351852, rs3811487, rs2295526,rs7256986,rsl5660 66, rsl2639645, rs4952197, rs4055940,rsl6935948, rsl989647, rsl7575933, rsll 655723, rsl 906159,rsl2640509,rs2732646,rs2424305,rs718516,rsll264375,rs 394873,rs6736892,rsl 543019, rslll31507, rs4466794, rsll 664999, rsl7806577,rs4568885, rs6679342,rsl325428, rsl6955286,rs2357128,rs7730449,rs4832333,rs2120108,rsl092866 6,rs271671,rs3847118 ,rs761172,rs6977661,rs6920118,rsl0928166,rsl510653,rsll20336 8,rsl7350303,rsl7659 166,rsl7646062,rs8044881,rs7289308,rs653411,rs9622773,rs2300 586,rs845779,rs96224 9, rs352170,rs7032385, rsll 981980, rslO404936, rsl7152216, rs7694146, rs7180782,rs2477 786, rs796800, rsl0927994,rs2130790, rs2183436, rs4261175,rs686307, rs2357947, rsllOlβ 113,rs7015200,rs4726423,rsl6927460,rsl887146,rsl0974527,rsl2 894860,rs6011111,rs4 316112, rs4358082, rsl835523,rs7953869, rsl2423796, rs629445, rs2740345, rsl 696762, rs7 537266, rs2920168, rs25681,rsl0110140,rsl7048821, rs4823694, rs9791974, rsl7151725, rs 10857619, rs3814511,rsl7401675, rsl561596,rs2792252,rs373690, rsl 1221359, rsl0519042 ,rsl0816846,rs9972481,rs6984483,rsl0900589,rs9946622,rs46726 29,rsl271558,rsl0933 588,rsl2341417,rs6813178,rs936929,rsl2622150,rs8071182,rsl24 48471,rs7934939,rs34 655356, rsl2078293, rsl 6833116, rs9515993,rsll764362, rslll65147,rsl499298, rs286024, rs4603484,rs4788844,rslll09239,rsll778610,rs511918,rs9895785 ,rs7860414,rsll24226 I,rs6920099,rs579298,rsl7149511,rsl0935698,rs6843895,rsll055 430,rsl348002,rsl721

Table 13 -33-

4746, rs9402716, rs6819474, rs7792410, rsll 69091, rs6970595,rs4955522 ,rs7140331, rslOO 40232,rs2868177,rsl2911081,rs2144825,rslll84723,rsl631395,rs 9858104,rsl7589074,r S7074395, rslO892095, rs3785780,rsl571097,rs9381303,rsl7151768, rs6438722, rs3106778 ,rs3934904,rsll631993,rs5998067,rs6559935,rsl467473,rs200151 5,rslll44967,rs24125 6,rs9425886,rs9483321,rs4443225,rsl034899,rs7138385,rs696728 2,rsll634290,rs38453 98,rsl0048837,rs7511475,rs9850300,rsl203907,rs4285747,rsl043 3674,rs4807191,rs385 0610, rs2664073,rs219904,rsll574597, rsll059100, rsll953038, rs7020658, rs6775014 , rsl 7208908, rs3751275,rsl3404325, rsl2042881,rsll763983, rs7255589,rs7206354,rs2427554 ,rsl384679, rsl7083650, rsl711781, rs4758648, rs2085796, rs868544, rsll688935, rs783636 2,rsll041850,rs206730,rs7426615,rs6801367,rs8179043,rs657150 1,rs9890514,rsll9467 48,rs4789061,rsl0950213,rs2270366,rs880450

Table 13 -34-

Table 14

dbSNP RS ID Flank rs4880820 GGATATTCTAATGGCA[G/T]TCGATGGCTCTTAGGC rs7380299 GGATGCTCTGACTTGC[A/G]CAATTTCAATACATAG rsl476659 GGATTACGGGATAGCC[C/T]ATAACAAACAGGGGTC rs7158108 GGATTATTTGTCTGAA[A/G]GCAAGGTAACAAGATC rs654128 GGATTTTCTTGTCGAA[A/C]TGCGAAGGCCTGCGCT rs4760403 GGCAAACTAGTGGAGC[A/T]ATTACTTAATTTCCCC rsl3083225 GGCAACCCAAAGATGA[G/T]GTAAATTGCTCCTGCT rsl981037 GGCAATATCTCAAGTA[C/T]GTTTGACACCATGCTG rs3850879 GGCACCTGTGTACGTC[A/G]ATGACTGACCACCCCA rsl571570 GGCAGCAATAGAAAAC[C/G]AACACAGGCCTGGGTA rsl2898861 GGCAGCATGGGTATCA[A/G]GACAGCAAGACACTGC rs3785200 AGGTCTTTTGGTTTTG[A/T] AACCAGG ACATTGGCA rsl7230766 GGCAGGCAATGGCCGC[G/T]AGAAGGTCAGTTTTGT rs2706526 GGCATCAGCTACTTAA[C/T]TGCACAGGAAAAATCT rs3099844 GGCATGATTTAGGGAC[A/C]ATTGCCTTTTCCATGG rsl7164680 GGCCACTGGAAACGCA[A/G]GCCTCAGGGCAGCTCA rs833503 GGCCCACAGGCACGTA[C/G]CGAAAAGCCCACTTGT rs9258605 GGCGGCCTGGATTGAA[C/T]GCCCTGCCCAGGTCTC rs333559 GGCTCACTGTAAAACA[C/T]GAACAGATGGCCAAGG rsll857638 GGCTCTCTTAGATAAA[C/T]GAAAGCATCTTTTTAA rs609794 GGCTCTGTCCTTATAC[C/T]GAATACGGCAACACAT rs2366144 GGCTGGG AACCAAAGG [G/T]AAAGAAACCATG ATAA rs6462873 GGCTGTGACCAAAAAA[A/G]GATAGCACAGGGAACC rs3983663 GGCTTACAACTTGTAC[C/T]CTCCACAGCAGCAGCC rsl713481 TCTCTTAATACTGAAA[A/G]TCACAAAATAGGATAA rs732509 GGCTTTCCATGTGGAA[C/T]TGCACCAAATCCTTAC rs2634711 GGGAAAATGCTTGTCA[A/G]AAACAGATCATCATCT rs4926925 GGGAAGACTGCTTATA[C/T]GGCTCTGGAATCAATA rsl6866649 GGGAAGCCAGGTCATA[G/T]AAGGCTATGTGTACTG rs9938068 GGGAAGGAGCTACCTA[A/C]GCTGAGGATGAAGACA rs8192249 GGGACACAGAACATAC[A/G]AAAGTAAACGTGGCCG rs3020092 GGGAGCTGTTCTGGAA[C/T]GACATAGGCCTCAACT rs9261376 GGGAGGTGGCAACGCA[C/G]AGTGACCTAGAAAAGC rs2413429 GGGATGAATGAGTTCAIA/GlAGTCTTGCAAAAGGGA rsll585488 GGGATTAGGAAGGCCC[A/G]ACAAAATACACTGAAG rsll641334 GGGCAACCCTCGACCA[C/T]GAAAGCAAGGAAATAA rs9821596 GGGCCACCAAATACAA[C/T]ATAACAAACTTAAAAC rsll38510 GGGCCACCAGGTCAAAIA/GJGATGCAAACCCCGCAC rs7091572 GGGGAGCGGTCATAGA[C/T]ATGGCTTGTCCAGAGT rs6824559 GGGGCTCAAATGCTGC[C/T]GAGAGTCTTCTTCCTC rsl0202684 GGGTAGTGTAGGACAA[A/G]CAGTGGAGTGCATGGG rs4920889 GGGTCCATCATGGTAA[A/G]GCTGAGACATGACAGA rs4870268 GGGTCCTTTCCAGTAC[C/T]AACCGCCTTAGGCTGG

rs6928585 GGGTGCCTTCACTGGA[A/C]ATAATTCAGAGCCACC rs41513048 GGGTGTCAGTTATTCC[A/G]AAGAACTCACACATAA rsl564569 GGTACCTCAGAGAAAC[C/T]GTATGAAATAGTCATT rs957293 GGTAGAATTGATTGCA[A/G]AGTTGCTTCATATTCT rs3741133 GGTAGACGGGCACCCC[A/G]AGATGTACCAACCTTT rsl7367971 GGTAGATAAGTAGTAGlC/TlAAAACTTTTGTTAGAT rs8057476 GGTAGCCTGGTACATA[G/T]AGTGCATTTAGGGCAT rs6082742 GGTAGGTTAGAAAAAAtA/TjTATTGTCATTGTTCAG rs2414164 GGTATAAACTTCTCCA[A/G]TCCTTAAGAATTAGCC rs9380173 GGTCACCCTATCCCTAIA/GlACCATATGCTGTCTTG rsl7720149 AAGCAGGGAAATCCAAIA/GJTCACTACTGAGAACAA rsl2124380 GGTCCTTG ATGTG ATA[C/T] AATTAGTGTCTTTAAA rsl7251664 GGTCGGGAGCGTGGAA[A/G]ATTCTAGACACAGCCC rs3731714 GGTGATTGCAAGTAAA[C/T]AACATGATATCAACCA rsl242780 GG I I I I I CTATGTCGT[A/C]ACAATAATGATCTCTT rs9328342 GTAAAACAGATTGCTA[A/C]TACCCAGTGTTGCTGG rs4723604 GTAAAAGCACCAAAAAIA/GJGCCTGATAAATGAATG rs594015 GTAAAGTCTACCTGAA[C/T]AGTCATGTATGGCCCC rsl6911099 GTAAATTCTGATACAA[C/G]CAAGTTTTCCTCCTCT rs41491846 GTAAGGCGTACAAATAIC/TJGAACAACTCCACCAAG rsl7446753 GTAAGTGCTTGTCAAAIC/GIGAAGAAATGAATAAAT rsl3228664 GTAATACTCCTTCTAC[A/G]ATCCTAAGATGGGTCT rsl7675800 GTAATCTGTAG GTAAA [A/C]CATACTTGTC ACACTG rs9405606 GTACAACTTGATTAAA[A/G]GCGGGCAAAAGCTCTG rsl7030905 GTAGGGGTTCAGGACT[C/T]ACATTAGAAATCCCTG rsl394175 GTATAAATGGAAGAAC[CZG]AGATTCACAAGGAAAA rsll201401 GTATATATGCGAGAGC[A/G]CTTTTAATTTGCTCCC rs2417173 GTATCTCCATTGCTTG[C/T]ATCTGGTATTGTTATC rs2172469 GTATCTGTTGGAAAAA[A/C]AATTCTAAGTGGCAAA rs7184060 AATTπACGAACAGCT[A/G]AAAATCCTCACTTTGA rsl6835609 GTATGGGGATGGGTCAtA/GJCTGAAGTCTGGTGGAG rs7690190 GTATGTCCTGGCCAGG[A/C]AGGAAGCTCTTAGTTC rs7645220 GTATTCTGCTTCTTAC[C/T]AAAACCAGGATCATAA rsl7086804 GTCAATTAGTCCATTA[C/T]GTATGACACAGGCTGA rsl7472050 GTCAGACCAGCTCCCA[A/G]TAGATCTGCGAAAGGC rs2460385 GTCAGTGCTTACTTTA[G/T]AAGGACACTGCTTAGC rsl7108192 GTCCACAATTAGGTCA[C/T]GTCCAGAATCCAAAAG rs924378 GTCCTGCCACCAACGA[C/G]AAGCAAGTGAATGAGG rsl500292 CTGGGGTAGAAGGAGC[A/G]CAAAATAAACCAAAAC rs562028 GTCTCCTCAAAGCAAA[A/C]TGCAGCAATTTCTCAA rsl0739959 GTCTCTCTGTTAAAAA[A/T]TTCCAAGTAGTCATTA rsll265797 GTCTCTG I I I I I IAGC[G/T]CTCTTCTCGAATGGTT rsll231991 GTCTGTTATTTGCTCA[A/T]CTCATACTGTAAGATC rslll24286 GTCTGTTTTGCTGCAC[A/G]AGTTCTGGATACAATT rs732431 GTCTTCACACCTGGCA[A/G]GAACGCGACCACCGCC rs3750164 GTCTTCCAGCCTGCAA[C/T]GTGTGGTACTTGAACT

rs4712005 GTCTTGATGCTTCATA[C/T]GCATTATCTTAATACT rs4288951 GTCTTGCTGGCTTAAA[A/T]AAGAACGCTGCCATAT rsl874631 GTCTTTGTATCACTTC[A/G]CACTCTTATTTCATGA rsl005948 GTGAAGATTGTGCACT[C/T]ACAAACTAGGTGATAG rs4650627 GTGACTGCTGTTAATA[C/T]ATAAGTCACTTTGTGG rs7969171 GTGAGTAGAATGTCTA[GZT]CATTTTGTCTGGTTTT rs633881 GTGAGTGTTAGAGCAC[A/G]GAGTCAGCTGGAAAGG rsl7428622 GTGATAATAATAGCTA[A/G]CTTGATGCATTTATCA rsl3359925 GTGATATAGGAGTATA[AZG]GAAGGATGACAGATTT rs2722769 GTGATATGTGCTGGTC[C/G]AAACCAGAAATCCAAG rs333896 GTGATTCTCTCTCTGC[A/G]ACCGGGGTAAGGGCTC rs4605059 GTGATTTAACATGACA[A/G]TATCTCATCAACAAAA rsl7070878 GTGATTTAGGGAAGAAtA/GlTATGTGACAGTTCTGC rslllO2O99 GTGCAGGTCACCTCGA[C/T]GGTCACCGCGCGGGGA rs7022103 GTGCCAAACTCAGCGC[A/G]AGGAAATTTGCATTAA rs4948034 GTGCTGGTTCAACTGG [A/G]CATG AAGTG ATAAGCA rsl6970288 GTGGCCTATTTCTAGC[C/T]CTCCACTGTGCTGAAT rs312615 GTGGTAACCATTGGAA[A/C]GAAAACACTGACATAA rs6974582 GTGTCTGTTGTTCTCA[C/T]CTGTTAAGTCCATAGG rs429000 GTGTCTTTGGAGTGAA[C/G]CTACTCAGAGATGCCA rs7215223 GTGTGGTTAATCCCCT[C/T]AATCCAGTCAGGAACT rs3765543 GTGTTTCTCCACAAAA[C/T]GGCCTGAAGTCCCCTG rs3843052 GTTAAATGTTACCATA[G/T]GAAAATCATCGATTGA rsl990150 GTTAAGGATAACAAGTtC/G]AACATCATTCCCTGCT rslll28722 GTTACACTGTGATATA[C/T]ACTTGTCAGTACCAAC rsl2072589 GTTACCACTGGACGAC[A/G]ACTGCTACATTTCTCA rs4926143 GTTACTAAGTGGTAGA[A/G]TAACCTAAGTCATGCA rsllO58212 GTTAGAACTTAAGTCA[C/G]ATACTCTTCTCTCTTC rsll679737 GTTAGAGCCTACATTC[A/G]CTATTCGTCACCTTTT rs2648459 GTTCAGGCAATGAAAA[CZT]TCAGGGAAGGGACCAG rs4949803 GTTCATTTATATGCAC[A/G]ATACCACATTTTGTAG rsll002861 GTTCCAGCCTAATCAC[AZG]CAGCTATACTGGCAGT rs7863684 GTTCCTACAAAGTTTC[A/G]ATGGAATTATGTCAGA rsl351920 GTTCTGGCTGTAGTAA[C/T]TGTCATTAGATATTAT rs6424866 GTTCTTCAAATCTGTA[A/G]GAACAAACAATCCAGA rs6492930 GTTCTTGATTCTTTAC[C/G]AACAGTGGCCTCGTGA rs4888041 GTTG ACTCAAATTTCG [A/T] CAAAC AC ATATACTTG rsl51291 GTTGCATGACTCTGAA[C/T]ATACCAAAAGCCACTG rsllO77773 GTTGCCAAATGTGTTA[C/T]GTTGTGTCTCAGAGAG rsl392567 GTTGGCACAGCCTTAT[G/T]AGGAAGATAATCCAAT rsl507275 GTTGGGGACCTCTGCA[CZG]TAAACCATATTCCCAA rsl383950 GTTTACTTTTGCAAAC[A/G]GGAAAGTTCTTTTGGG rs6954522 GTTTATTTGGAATTTG[AZG]ATTTACCTGTATTTCC rsl2859979 GTTTGTAGATGTCGGC[AZG]ATGAGCTCGTAGCGCT rs6077332 GTTTTCTTCTCTGTGA[AZG]GTTATCAATCAGCAGA rsl834037 AATATTACGCTATTAA[AZG]TCACATACATTCCACT

rsll638667 GTTTTGAAAATGACCT[A/T]ACTTGGCAAAGGAAAC rs4520068 GTTTTGL I I I I I GTAA[C/T]AGTCATCCTAATCGGT rs7535790 TAAAAAAGACACTGAT[A/G]AGAAACACTGAAAAAG rsll649883 TAAAAAGTAGCTAGCC[A/G]AGGAGTGAAGCCCGAG rsl6871519 TAAAACAAGGCACCCAIC/TlTGCTGAAAAAGAGAGC rs9285009 TAAAATAGATTTTTAT[C/G]AAATACACACCAGACA rsl424219 TAAAATCCAGTCACAG [A/T] AAGTTACATATTGCAT rslO8O5421 TAAAG AGTCCCTCCTC[A/G] AGTTAGTCCAATTTAA rs6456762 TAAAGATATGTAGTAG[G/T]CCCCAAAATTCTACTT rsl2647211 TAAAGCAGCTGGATAAIA/GIGATTTGGTATTTTTAA rsl360224 TAAAGTACAACTGGTA[C/G]ATAACTTCTGCCCTTT rs6861743 TAAATACAAAGGATTC[A/G]AAATTTACAGTTTACA rs2804609 TAAATGGGAGGAGAAAIC/TJGGTGAAAGACTAAAAG rs870992 TAACAATGCCTTTTCA[C/T]GCACTACTGACTTGCA rs4238326 TAACAGCCAAGTCCTA[C/T]TAAAGCACTATTTTAA rsl7649817 TAACATCACACTGAGG[A/C]ACCACTTGCCCCAAAC rsl524007 TAACATGATATTTTAA[C/T]GGAAGCAGAAAGTCCT rs2075800 TAAGAGAAAGG AATTG [A/G] AGCAG ATGTGTAACCC rs7331396 TAAGCGACCAGGAAAA[C/G]ATTGCGAGCTTGAAAG rsl534261 TAAGCTG ATATTTTAG [G/T] CCCTATCAG CCTGTGT rsl6831235 TAAGCTTTTAAGTACA[A/G]TACACTCTTCTAAAAT rslll39579 TAAGTAACTTGGCTCT[A/C]AAAGAAAGCTCCTGAA rsll864983 TAAGTTCCGGGATACA[C/T]GTGAAGAGCATGCAGG rsl022135 TAATAAAAGGAAGGAGμ/qATGTGTACTGGAGAGC rsl7818634 AAGATCTAATGGGTAGIA/GlAGTGACTTTGTGTAGA rsl0214636 TAATACCAACAACTAA[A/G]GTTTGCAAGCACTTAA rslll76841 TAATAGACCAATGATAtC/TJGTGAGGAGGGAAGTAG rsl39515 TAATGTAGCTAAAATA[CZT]GTAGTGTGACCTTTGA rs6898279 TAATTAAAAACATGGAIA/ClACAGAGTCAGAGTGTG rsl412981 TAATTATTGAATTAAA[C/T]GCTTTGCCAAATAAGG rs2407183 TAATTCATAGGAAGAC[G/T]CAGGTTAGTCCAAACC rs7162623 TAATTTATAGCAATCG[C/T]CAATTTCAATGGTATA rsl911429 TACAAAGTTGTTAGTA[A/C]GGGCAATCTGATCCTA rsl461349 TACACAAATTGCCTGG [A/C] ATATAGTAGTCATTGT rs327101 TACACTGACTCACCTA[A/C]AACTCTGGCATTACAA rsll939328 TACAGTGGAATGCTGA[A/G]GGCTAAACGTTCAGTG rslll59993 TACCACAAAAATTCCA[C/T]GATGAACCCAGTACCA rsl6860351 TACCATATTGACAGTA[A/G]GTATCCACTAGGTAGG rsl0756759 TACGTCAATACGCATA[C/T]TACAATGGTTGGGCAC rs7576174 TACTAAATGCTCCAAA[C/T]ATGCAAGAATGTCTCT rs7581649 TACTACTCACATCCAT[C/G]AGTCTTATCAGTTCAT rsl2037298 TACTCTGTCAGATACA[C/T]TACTAGAAGATGGGCA rs2290637 TACTG ACAAAATCAGG[A/C]CCACAAGG AG ATAAAT rs7224773 GTCTCAGGGACTGCAA[A/C]TATGTATTCAGGTGAG rs319777 TACTGGAAACTGGAGGIA/GIAAGACCAATCTTGTTA rsl0095192 TACTTACTCTCTGGAA[A/T]GACAAGATGTTCTGTG

rslll04004 TAGAAACCACACAAAG[A/C]CTTACTTACTCTTCCC rsl7079392 TAGAAAGCTGTAATTG[C/G]AACAAGATTTGTCATC rs2284 TAGAACTAATCCCTCA[C/T]GGAGAACGTGGAACCA rsl0842386 TAGAACTTGAAGGGAA[A/C]CATGGAACTAATGAπ rsl529570 TAGACTAAGGGGACGC[C/T]GAGTATTAAACAGGTT rslll58818 TAGACTCTTTCCTAGA[G/T]CCTATGGAAGTAATGC rs4876815 TAGACTGTAGGGTCTA[G/T]ACTTATCCTCAAGAAT rs637993 TAGAGCCATGCCTAAG [C^CTTAGAAAAAAAGTTC rsl6833240 TAGAGCTTCCTCTTTA[A/G]AGATTCATAGAACGGG rs7150844 TAGATACCCTTGGAAA[C/T]TGCAAGTGTAAGAATG rsl401539 CTCCAG GTTACTTCAT[G/T]GTCTCAAATAG CTATT rs2075303 TAGCAAATCATAATCA[C/T]ATTCAACGGACAGTTC rsl6950199 TAGCCCAATGTGGCTC[C/T]GAAGGGGTTAGGTGCT rs2218345 AAATGTTCCTCCTGGA[A/G]AAGCTGTATTCCCTTC rs41331849 TAGGATGGGATAGAAAfA/GlTGAGAGGTACTATTTA rs7215329 CCACACCATTGTGACC[A/G]G AAAG AG ACCCAAGGC rsl7758650 TAGGGACCAGCAGAAT[C/G]ACTATGTGCTAGAGCG rsl0953597 TAGGGGAAGAAAGGTqC/TJAGTAGAAGGTGGTAAC rs6433659 TAGTAATCTACGGCCA[A/G]GCTTTCACAGCTGTGG rs6430952 TAGTCATTTAGGAGAC[A/C]GAAATACAAAGACATT rs7995993 TAGTTGATGGTTAACAtA/GjTCAAGCTGGAGAAGAA rs4933935 TATAAATTGTTGATGAIA/GITAAGTATCCTGCTTGT rsl486498 TATAAGTGCCTAACTA[C/T]GAGTTTTCTGACCCTT rs321930 TATAAGTGGCATCACG[A/G]AGTGGCACCCTGAACA rsl3061546 TATACAGGAGGATAAC[A/G]GGGTTCATGACAAGCT rs2229360 TATCATGAAGCCTAAA[C/T]GCGATGGATATATGTT rsl2524781 TATCCAGTTCTGAACC[A/G]CCTTGCACTGTTCTGT rs6673013 TATCCTTTTAACCTGC[A/G]CTTTAATAAATGTTAA rs32477 TATCTAGTACACTCAG [C/G] ACGTCACACAATTCTT rs4898690 TATCTGAACAAAGAGA[A/C]CTTCCCTGACCACCCT rsl538291 TATCTGCTAAGGCAGA[A/G]CATCACAAGTGGCTGC rs8180738 TATCTG GAATGTTTG G [A/G] ACACATGAACACACCT rsl6865107 TATCTTCAACTACCAA[A/G]GAAAGTTCAGGAACTT rs9562187 TATGAACAAACAGAAA[A/C]TGTCAACAGAGATAGA rs7745576 TATGAGACACAATTCC[A/G]GAAGAGGAAAACAGCT rsllO46631 TATGAGTAGCACTACA[A/G]TGAACGTATTAGTGCA rs4892047 TATGGAGACAGAAACC[A/G]CCCTATAGGAAGGAGC rs7068022 TATGTAAATTGGTGCT[C/G]AGAACTCAGTTGTAAA rs960246 TATGTCTTGCCAGAAA[A/C]TATTAAAGACCCCTCA rs9650554 TATGTGTGTATCTGTA[C/T]GTGCAATCACAAAATC rsll018078 TATGTTGCGTGAAAAA[A/C]ATACTAAACAGCATTA rsl032363 TATTGCCAAATTGTTC[A/G]AGACCTAAGAAGTTAA rs4918909 TATTGTAAATGTGTAAIC/GJTAAGTGAAAGACAAGC rsl7661265 TATTTAAAGTGCACTA[C/T]GTCTGAAGTATGAAGA rsl384771 TATTTATTGTGTGCAAIA/GlTAAAGAAGAATGTAAG rsl0462466 TATTTCAATATG AAAG [A/G]CAGG ACTTCAATATTT

rs7779029 TATTTCTAGAGGCCCA[C/T]GGGTATTTACACTTTT rsl2746613 TATTTGTTGAGCATCC[A/G]ACTTTATCATAATTAC rs28397045 TCAAAAGGCTTATGTA[A/T]AGGAGATTCTACGGCT rsl516443 TCAACTTTTCTACCAA[C/T]GATTTTGCATTTATCT rs583569 TCAAGACTAACAGGGC[C/T]GAAATAGCAAAACCTC rsl529039 TCAAGACTGACTAGGA[AZG]GAAGAGTTTTAGTATA rs2537604 TCAAGATAAAACAGAC[AZG]ATAATAGTCTCAGTAA rs9909791 TCAAGGGTCTCTTCTA[A/C]ATGAGGAAGCAACTGT rs7780106 TCAAGTGGGTTCAGAA[AZG]AAGTGATTTGGGTTCA rsl689754 TCACAGAGATTGATCA[A/T]TAACTGAGGATGCCAA rsl0880415 TCACAGATAACTATAT[C/T]ACATCAATCTCCTGGT rsll586533 TCACAGATGCTCCTAC[A/G]ATTTGTAL I I I I I I CC rsl2496938 TCACAGGACCAAGCAC[A/G]ACTCTTACTGTGGTTA rs4664327 TCACAG I I I I I CTAAA[A/G]TCAAGTTCCAATTATC rs4871208 TCACCCCTCTTTGAAA[CZT]AGTAGCTTTAAATTTA rsl576565 TCACTAGTTTTGTATC[A/G]GATAAAGTATACAGTA rs3181092 TCAGAAAGAGCTACAA[CZT]GTGACTAAAGGAGGCA rsl6944492 TCAGAAATAAGAGTGT[A/G]AAGTTCCAGGAAATTC rsl7774599 TCAGAACATGGTGGGAIA/CJGGAGACCCATAAGATC rs259971 TCAGCGAGGATTCTAAIC/TIATAGTTCATCTCAAAT rsll794075 TCATAACTGTGTTACC[CZT]GAGTGACATTTAATTT rs6922518 TCATACATAGCACTCC[CZT]GAGTAGATTAAAGATG rsl7301479 TCATAGAATTTCAGTC[CZT]AGGAGAATAAGCAGAC rs9736587 TCATGACAAAATTAGA[AZC]GGGACGCATATCTCTG rsll766104 TCATTC AATAG GTG AG [CZT]AGATAAATGTGGCCTA rslll86662 TCATTGGTTCTCAAAT[CZT]AACGCTGTCCTCACTA rsl375799 TCCAAAATGTAATTTC[CZT]AGTAGCACACTTCTAG rsl511252 TCCAAGAAACCATGAA[CZT]GATAACCTAGACCTAG rs7184260 TCCACAAGAATCAGTA[AZG]AATGGTGACTCTCAAA rs6906652 TCCACCTGCATTTAAA[GZT]CAGCACGTGTGTTTTT rsl0982237 TCCAGATGCTGACCAA[CZG]ATGACTGGTGCTGTGT rsl625495 TCCAGCCTTGGCGATA[CZT]GGCCAGACCTTGTCTC rs2254244 TCCAGGCCAAACATAT[AZT]AGAGAACATAGGAGAA rs4981565 TCCATACATACCCAAA[AZG]GCACAAGAGAGTCAAA rs7647035 TCCATCAAGAAATCAG[CZT]CAATTTGGTTGCTGGG rs4669100 TCCATCCTTATTCCAA[CZT]CCTCTCATCTTCTATC rs538562 TCCATCTCCAGTCTTA[CZT]CTGTAAATGGTAACTC rs6729167 TCCATGL I I I I IACAA[CZT]TCTGGCTTTATCACAT rsl0871408 TCCCCTCTCTGATTCA[AZC]CACATTATTCATCACC rs542930 TCCCTATTCATGAGTC[AZT]CTTAATAGCCATCTCG rs41516344 TCCGGACAACAAAGCA[CZG]TGAGTCATATCTGAAC rsl7070595 TCCTAAGTATTTCTCA[AZC]GTCACTGTTTCTGTCT rs8176681 TCCTATTGACAGACAC[CZT]GTGG I I I I I I CACTGT rs2083685 TCCTGATGCAGTGTCA[CZT]GGCTATTCAGATTAGG rs4243549 TCCTGGAAATTATGAA[AZT]TGTCTGTAGAATGTTA rs4689490 TCCTGTCTCAGCCAGT[AZG]ACAGTGAATCTGGAGG

rsl7557564 TCCTTTATGTTGCAGC[C/T]GCCTACCTTGCAGACC rs2071680 TCGACGTCCTGTTCGC[A/G]GAGTTTGAGCTCAGGT rsl3220395 TCGTTGCCACAGGAAT[A/G]AGAAATTAACAGCAGA rs911735 TCTAAACTATCATTCG[C/T]CCCTCCCAGCTACTCC rs741584 TCTACAATAAAACCAT[C/G]AATCTCAAATCATTGG rsl7246133 TCTAGCTCTGAGAGTC[A/G]AGGAACCTTTCTAAGC rsl7707124 TCTAGGAGAGCCTAGA[A/G]AATGTATAATTGTTCT rs715778 ACGTCCACTCTGATCA[A/G]CCAGTGCGATTGGCAC rs7974564 TCTATGCTTTGTGAAA[A/C]AATCTAATACTGCAAA rslO786197 TCTCAAGCATCCTTGA[A/G]TATCAAAAGGAGAAGA rs381463 TCTCATGCAACCTTGA[C/T]GTGAATCCTCAGAGGA rs4728425 TCTCCTCTCCAG CTCC [G/T] ACATTGTG CTGTAAAC rs41447 TCTCCTTCAGTTGCTC[G/T]AATCAATCATAGGTTT rsl6993082 TCTCTTTGGACCCGGA[C/T]GTTTTTACACTAATCA rs6777252 TCTGACTCCTTTCTAC[A/C]AAATGCTTTCTCCTAC rs3905755 TCTGCCTTCCTCTTCA[C/T]GTGGTGTCCTGTGTGT rsl3354365 TCTGCCTTCCTTGCGC[C/T]AATGTTTAGTTTCAGA rs432983 TCTGCTGAAGTGTGAA[A/T]TGTGAAGGCACTGCCC rs2656275 TCTGGAGCAAATGAAA[C/G]AGTCAACCAAACTGTA rsl288340 TCTGTAI I I C I I I GAC[C/T]GTAAACTACL I I I I I G rsl3036801 TCTTACCTAGCAAAAA[C/T]GAGGCATCATGGAAGT rs7895883 TCTTCAAAACAGCTTA[A/G]ACACGAATCCAAACGG rsll645428 TCTTCAGGAGTCAGGG[C/T]ATTGATTCACCAATTC rsl6891525 TCTTCTTCGGATTAGC[A/T]AGTGTCATGTAACTCC rsl395063 GTGACAACCGGGACCA[A/C]ATCCAACTGGGCGTTG rs4823590 TCTTGCCCATCTGGAA[A/G]CTAGGAACTGGCCTCT rsl0885348 TCTTGTAACTTGCATA[A/G]CCTGGAAACGTTTCTT rs4075737 TCTTTACAAGCACCTC[A/G]AGAGGAGTATGTAGGG rsl2652689 TCI I I I C I I CACTTGC[A/G]CCTCTTCATTACTTGA rsl532815 TCTTTTGGCCTCCTCA[A/T]GTATTATATAGGAGAT rsll690820 TGAAAGTTACAGCTTC[C/T]ATTAGGTG I I I I I GGT rsl2492701 TGAAATCCTTGAGATA[A/G]GTAAGCTGGTCATGCC rsl2240092 TGAAATTATGGTAAAC[A/G]GACCTCCCAAGGAGAG rs6426016 TGAACAAAACACATAA[C/T]GTAGGCAGTGTGATTC rs2927370 TGAACATTCACGTAAA[C/G]TCTTTGGACATATGTT rsl3705 TGAAGCCTGGAAGATA[C/T]GCTCACG I I I I IGAGG rs473598 TGAAGGGTCTCCTACC[C/T]GCCAGGACTTGGAACA rs2053642 TGAATCCGAGTGTCAC[C/T]ACTTCCTAGCTCAGTG rsl7150823 TGACATCCTCAAACAC[A/G]GTGAACTGAAAGCAAA rsl7450279 TGACATCTTTTGTAGA[A/G]GTCTTCCCATCTAGTC rsl286170 TGACCTACCATCTGAAIC/TJACGTTAAGAAAACTAA rsll689747 TGACCTTGCTGAAGGA[C/G]ACGAAGCAGCTTCCGG rsl0739632 TGAGAACACTGTTGCA[C/T]TAAAAGAGATTAAAAG rsl2328204 TG AGCTAAACG ACCAG [C/G]CTACAAAG ATGCACAG rs4757710 TGAGGAGTATGATGGA[A/C]GATGCTCTAGAAATTC rs4128456 TGAGTAGGCGAGTGTT[A/G]AAATATGCAATCTAGC

rs37017 TGAGmCTAAAGGAG [A/GjAGCTAAAAATAAAGAC rs884474 TGATAAGCATGCCTGA[AZT]AAGATGGAAAAAACGG rs7678245 TG ATAG AATCCTTAAG [A/G] AACTGTTAACTGGTTG rs7240116 TGATGATTAACTGTAA[GZT]TCATGACATTATGCAA rs7727355 TGATTAAGAATCAAAC[AZG]AGGTAAGGAGAGAGCT rsl454621 TGCAAATGCCTGCTGG[AZG]ATGGGGCAGAGAAAGA rsl6831751 TGCAACAGACAAGGCA[A/G]AAAACCTTTAGCAGTG rsl7016778 TGCAAGAATAATGAGTlC/TlACAGTTGGTGATTAGA rs4837710 TGCAAGGCTTAGAGAA[A/G]TGTAGTGACTTCCCCA rsl7391944 TGCACGTGGGTTTCTA[AZC]GCTAGGCTCTTGGCTC rs302652 TGCAGCACTAATTCAC[AZT]AATACATGATAAGGCA rsl2025922 TGCAGGAACAGAAGAA[GZT]AAACACTACAGGTCCT rslll38367 TGCATCTCACTCACCA[CZT]AACCAATGGAACTAGA rs9640378 TGCATGGGCAGGTCAA[CZT]GTCCCCAAATCACGTT rs4774353 TGCCTCAGTGAAAGAA[AZT]AGGTTCTCTGAAAGTT rs4973451 TGCGTGGCACGTAGTC[AZG]AGTGCTATGTGGGCCT rsl450970 TGCGTTTCTCTGCTGA[CZG]TAATGACGTTGAACGT rsl6961350 TGCTAAAAAGTTGCAA[CZT]AGGTGTACATATATTT rsl413797 TGCTAAAACACCAAAA[AZT]TGTCTCTGCTTGTAAG rs6453613 TGCTATGGGGACTCTA[CZT]GGTGATATGGAATGAC rsl581541 TGCTCTGATGATAATA[CZG]GTTGGGAATTCAGCAA rs9944334 TGCTCTGCCACAGAAA[AZG]AACGAAGCCTCAGGCC rsl903263 TGCTGAGGCCAAACCA[CZT]GACAAGGGCTAI I I I I rs234363 TGCTGGGTTATATCCC[GZT]CCGATCATTGTCCCTC rs2369294 TGCTGGTGAGGGTACA[AZG]AGCATCAGATATTCTC rsl991107 TGCTGTTAGTCAAGTC[GZT]CGGAGCCTCAATTTCT rsl3180965 TGCTTAGCAAACTAAG[AZG]ATAACAGTTCTATCCA rslll70467 TGCTTCATAACTGTTA[CZT]CATCCCTATTTTACAG rsll712379 TGCTTCTTCCAGTGTA[CZT]CTTCTGCCAATTTCAA rsl2590815 TGCTTGTCCATGTAGA[CZT]GTGCTTTATTTATGCC rs4866643 TGCTTTCATTTTCTGC[CZT]GAGATTTTAAAGGATT rs2907370 TGGAAAAAGTGTTCAC[AZG]GGCTTAGGATACTGAC rs312799 TGGAACTGTGAAAATA[CZG]GTTTGTGTTGTTTTAA rs687723 TGGAAGCCAAAGGGTC[AZG]CTGATGATTTGCGTTG rsll961920 TGGAAGCTTGGGAGGG[CZT]CAATTTAGTTAAACAA rsl2833271 TGGACTAGATCCCAGC[GZT]CCAATCTGATTTAATA rs3792896 TGGAGAAAGCAGTACC[AZG]GAATGTTTTAGAAGCA rsl828591 TGGAGAAGTAAAAGCA[AZG]GATGGAATGGAAGAGA rs4875484 TGGAGATGTTGTTGAA[CZG]AGAGTCAAACTCTAAA rs7108023 TGGATCAATGTAAATC[AZG]ACCACTCCTGAAACAC rsl983230 TGGATGGATAGATTGA[AZC]AATGGCCACAATTTAT rsll900761 TGGATTAAAGGGAAGA[AZT]GAGAGAAGCTGGCTCC rs859369 TGGATTATACCAACCA[GZT]GCCAGTTAGAAATCTC rs7006163 TGGCAGGGGAGGGATA[CZT]ACACAAACTTCCTTAT rsl929009 TGGCAGGGGGTGGCAA[CZT]GATTAAGGGAACTGCA rs6500312 TGGCCCACAGAGTCAC[AZG]AGGCCGCTGTATTAGT

rs4806798 TGGCCCATTCTTAAGG [C/T] CAG CAATTAAG CTCCA rs2255909 TGGCCTTGCAAGCAGA[A/G]AGTGAGATCCCCTCTC rsl554903 TGGCGCTTTATTGCAA[C/G]AAAGGCAGTTAGGGGT rs6605516 TGGGAAGTAAGCTGGA[C/T]GAGAGAATGTCAGCTG rs6901703 TGGGAGTGATACTGTC[AZT]CACCTAAGATCAAAAC rs2884249 TGGGCAACTTAATCCA[CZT]GAATGTTGTCTGTATT rs5756219 TGGGCAGAAGGTCCGA[G/T]AATGATGAACGATGCT rsl7537262 TGGGGCAGGGTGAACA[C/T]GGCTGCTTGAAGAGAC rsl498599 TGGGGTTTATGGAAGC[A/G]CCAAAACATGATGTAG rs7632122 TGGGTGCCTTTCAACA[C/G]ATTCCTCTTTGATTTC rsl800562 TGGGTGCTCCACCTGG[C/T]ACGTATATCTCTGCTC rs4368678 TGGGTGGCTAAGCCTA[G/T]CAACAGACTTCCTCCA rs4965546 TGGTAGACATAAGAGA[AZT]AGGACTGGAGACTTGG rs258242 TGGTATCAAAGTTTTA[C/T]CTTCCATTGAAATCCA rs9891216 TGGTATGATCTGAATT[C/T]AAGAGTCCTTTCTGGC rs864712 TGGTATGCTGAAAGATlA/TlAAGATAGTAAAATGTG rsl3337356 TGGTCAGCCATTTTGA[C/G]GGAACTGGGGCCCAGG rs3798343 TGGTGACTTTCTTTGC[C/G]CCTCTCCACTCTTACA rs4685814 TGGTTTTACTGTTGAAlA/TlATTGCTGGAAACAGTG rs6823189 TGTAAAGCCTTTTGTA[CZT]ATACTGTATGAACAAC rs771828 TGTAACAAAAATTGTA[CZT]GACAAATGCTTCTAGA rs2741706 TGTAGGTTCCCCTGTC[AZC]ATCTGGCTTAATCGGG rsl3098512 TGTATTACTGGCATGA[CZG]TATTTCGGGATTGTAT rsl7792641 TGTATTATTTTAATGC[AZG]ATATCGATCAGCAGTT rs622274 TGTCACCAGTGTCACA[CZT]GGAAATGGAAACCTAC rs2741688 TGTCCATTGTGACTTA[CZT]AGCTGTCTATGCCTCT rsl3005519 TGTCCGGAAGTCCTAG[CZT]AGGTGAAAGGTTAGGT rs2532070 TGTCTATTGTCCTTAA[AZG]CAAGGCTACATCAAGG rs2248221 TGTCTCTCACCTGAAC[CZT]GTGTAGCAGGCCCCTC rs4430517 TGTCTGCTGTTGAGAA[CZT]GAAGGATTACTGAGCT rs7849812 TGTCTGTGACCTGCCA[CZT]AACCTCTTTGCCTCTT rsl331161 TGTCTTCACATTTGAC[CZG]ATATGTTAATTGATTC rsl241181 TGTGAAGAACAGCAAA[AZG]GGTATATAAGTCTTCA rs34037364 TGTGAGTACAAGAGAA[AZG]AGGATCAAATTGCAGC rsl2029096 TGTGCAGGTGTGGTTA[CZT]GCATTTTGAAGGAGCT rs41438052 TGTGCATCAGAGACAA[CZG]AGGAACTTTTAGAAAC rs4072815 TGTGGAATCCATTCCC[AZC]ACTAATTCAGTCTCAC rsl6880618 TGTGGAGGCGACAATC[AZG]AGTAAATCCACAGTTC rslO93523O TGTGGGTATGAATCGA[CZT]GGTGTCCCTGGAGTGT rsl6827546 TGTGTCACACAGGTCA[CZT]TCCGGATCAGACGCCG rsl0120949 TGTGTCCTTCTGTCAA[CZT]ATGTCTAAAACCGCCC rsl550329 TGTGTGCTGTTTGACA[AZG]CTAATGGCAATTTATA rsl532661 TGTGTGTTACAGAACC[AZG]GCTACAACCTCAAAAG rsl942991 TGTGTTATCAAGTTAC[AZT]CTTAGTGCATGAGTTT rsl2773375 TGTTAGTTTCCACATA[CZT]GTπTCCCTGTGTTGT rsl7053181 TGTTATGTATTGGGCA[CZT]AAATCCTGGTTGAAGA

rs6948280 TGTTGAGTTGGGTCGAlG/ηAGATTACATTAGTGTC rs6857600 TGTTGTTTTGAGTTGC[A/G]CAATTTGAGCTTTCCA rs5771040 TGTTTCCATAAGATGC[A/G]AGGAACAGGTCACGTA rs3806015 TGTTTTGTGGACTGCAIA/GJATGTTTCATAAGGATT rsl6900210 TTAAAAACACAGGGGC[A/T]ACATTGTTTGAAATAA rs2196493 TTAAACAG CTC ATG AC[A/G]GTATATTACGTATATG rs3780830 TTAAATCCACATTTTA[C/T]GGCTCTCTACTACAAA rs6591256 TTAAATGAAGTTTTAA[A/G]GATACAACATAAACAC rs372201 TTAAATTGTGAACTTC[A/G]AGAAAAAGAGTTCTCG rs4833736 TTAACACACTCTCCAC[C/T]ACTACCTCTGTTCCTC rsl2677931 TTAACAGCAAGATTAC[A/C]AACAAAATTTTAGCAA rs41469048 TTAACAGTAATGGAAC[A/C]AATGTGAAGCTTCTGC rsl6928918 TTAATTTGCACAGGAA[C/T]AGTTTCCATCTCTGGA rsl7061055 TTACACTTCCTTAAGC[G/T]CCAATTTTCACACCAA rsl884137 TTACCAGGTCATGAGAIC/TIGAACAGTGACTAGAAG rs7935922 TTACCAGTCTACCTAC[C/T]ACTGATGGCCATTTAG rs3218426 TTACCCACAAGGATTAIC/GJGCAATCTGCATCAGAC rs2102121 TTACCCCAATTTTTAA[C/G]TCCCTTGCTCACCACA rsl0739734 TTACCCCATTTTCTGA[G/T]GAAGATACTGACGCAT rsl7070659 CAAGTGTCACAACCCA[C/T]TGAACTGATGATCAAA rs6798854 TTACTTTTGAGATCAC[A/G]AAATGAGCATAAACAG rsll974698 TTAGAGAGATGCCTAG[A/G]AGAATGTAACACAAAA rs3001033 TTAGCTTGATGCACAA[A/G]GTCCTCCATGCTTGGC rsl6930635 TTAGGATAATTCCCCA[C/T]GCCCTAGTGGTCCCTA rs332607 TTAGGTCCAGGTTTCT[C/T]AACAGCAGTGCTACTG rsl0192362 TTAGTCATTTACACCA[C/T]GATGGGCTTGACAAAT rsl7680989 TTAGTTTAGCTGGCAA[A/G]TCAAAGTAACGTACAA rs2059188 TTAGTTTGATTTCTTC[A/G]CTTCAGTTTGTATATT rsl0190462 TTATAAAACTCCATCAIA/GICATCGACAAAATAATG rsl352755 TTATCTAAGCAATGAC[C/T]GGAGCGACTTCAAATT rs483285 TTATCTTCAGTAACCC[A/C]GAGGACTAAGGATCCT rsl6908921 TTATGCCAGTACCATC[A/G]ATCTATTTTCTCAAGA rsl2503342 TTATGG AATCAAG ATG [A/C]AGCTTTACAGTCAGTG rs657677 TTATTTCGGTCTGCAA[C/T]TTAAGCATTTACAGCA rs8075803 TTA I I I I I CAGTTCCA[C/T]ATTTCTGACTCCAGGG rs7325670 TTCAAGAGGACCTAGT[C/T]AACTCAGTTTCCTGGC rs363226 TTCAATGCGGAGGACA[C/G]GTTCAAGGCCACTGCT rs4435740 TTCACATTCAGTTTTG [A/C] AACAATCTTG AAATAA rs2867427 TTCATAACAGCTCCAA[A/G]TTGGAAACAGCGCAGA rslll50090 TTCATAATTGATTCCA[A/G]ACGTGCATGAATCTTT rs4592318 TTCATGTACCTGTTGG [G/T]CACGTTTATGTCTTCT rsl6864914 TTCCAAATTTGATGGA[A/G]CATGGATTCACTATAA rslOO5O17 TTCCACCAAGTATACA[C/T]ATGAGAAAACCACAAA rsl6874136 TTCCACTCTCAAGCTA[C/G]CTGTATCTAGGAAGTG rsl0514053 TTATCAGCCAGTATTG[A/T]AATTTGTCAATATATC rsl252131 TTCCCTCCTGTGATAA[C/T]GCACTAATCCATTAAC

rs3804500 TTCCTCCTGACTGCTC[C/ηAGAATL I I I I I GACTT rs3132524 mCTTGAGGCTTCAG[AZG]ACTACAAAAAGGCCTT rsl7150307 TTCCTTGGGTCACTAG[A/G]AI I I ILI IACTTCAAG rsl7435970 TTCCTTTCTGCCCATG[G/T]AGGTTTGGGTTTATAC rs8178649 TTCCTTTTGTCTGTAA[C/T]AGATTTGAATATGTGT rsl7792748 TTCGAAAAGATAAAGA[C/T]GATACAACATGAGAAA rs3799633 TTCGCGAGCCGTTACC[A/G]CTCTAAACGTCCTAGG rsl2994568 TTCGTTGCAGAAGCAA[C/G]CATTTGATCCTCCATT rsl6976432 TTCGTTTTATGGCTGA[AZG]GAAAGTTGTACAGAAA rsl907861 TTCTAAAGAATAACTAIC/GIGAGCAGAGAAAAACAC rs6123252 TTCTCAGCTCAATCTA[AZG]AACTGCTTCCTTCTCC rs7047812 TTCTCATTG I I I I I IA[AZC]GGACAACTTGTACATC rsllll8475 TTCTGCAGGGAAATGC[AZG]GAAACTATCTTAGGAT rsllO37654 TTCTGCTTTTCTGGAA[AZG]ATAGCCATCGAACAAG rs2116282 GCAATTCAAACACATC[AZG]CCAGGCTTCACTTTTA rs3866685 CATTACTAATGACTTA[CZT]GAACTTGAATCAGATT rs3774529 TTCTTCTCCTGTGGTA[AZC]AAGAATATGTGTCTCA rsl896634 TTCTTGCTCAATTAAA[CZT]TTCAAAACATGTATTG rsl393722 GGACACCTTGTATGAC[CZT]CTTAGAGAAAGGAGCA rs2803956 TTCTπTCATGAAAGA[CZT]ATTTGGCAATAGTTGG rsl872026 TTCTTTTCCTGCCCCC[CZG]AAAGGTGTATGACATC rs8190581 TTGAACTGACTTCTTA[CZT]GAAATGAGGGCAGAAA rs7630709 TTGAAGCAAGTCGGCA[GZT]GACCTCAGTGGGAAAG rsl890968 TTGAATTGTGCTTAGA[CZG]CTTTTCCAGTAGCTGA rs6729671 TTGACCCATATTCAAG[AZG]AATGGCAGCCTCAACA rs854664 TTGAGACTCTGTACAA[AZG]TTCCTACCTTCCCCAT rsl393597 TTGCAACTGATTATCA[CZG]TAATGTTGTGAGTGGT rsl7760296 TTGCAGCACTTACCTC[GZT]AATTACTCTACATGGA rslll26997 TTGCATTTCCACCAAC[AZG]ATATTTAAGAGTCCTC rslll81133 TTGCCCCACATTTGGA[CZT]GAGCCAGTAAGAAAAT rsll762469 TTGCCTCTAACACTGA[AZT]GATATTCCACTCATAT rs2471017 TTGCCTGGCACTTAGT[AZG]AACAGTCAATGAATGG rs974332 TTGCTACAGAGAAAAA[CZT]GAACTAGGATAAGGAA rs9376578 TTGCTAGCATCCTACC[AZG]GGCTTTCAAAAGACAA rsllO3169O TTGCTCTAGACACTTA[CZT]GTGAGTACAGCCTTAT rsl7215701 TTGCTGTGGTTGGCCA[CZT]AGTAGACACACGCTTT rs7750010 TTGCTTCAGTGCCTTC[AZG]ATACTGTAAACTTTCT rsl2089247 TTGGCAAAGGGTCCTA[AZG]TAAAGTCACAGCATCC rs3131294 TTGGCCAAAACAACCA[CZT]CTGAGAATCAAAACCA rs6103592 TTGGTGACTATGGCCA[CZT]ATAGTTTGAAGTCGGG rs7797180 TTGGTTCTAGTAAGCA[AZG]TCACAGTACTGTTTGT rs7071963 TTGTATACCTGCAGAA[CZT]GGAATTAGTTAGAATA rsl2678791 TTGTATCAGTTGTTTA[CZT]GTGCAAATCATGTGTC rsl2046378 TTGTCATTAATGTGAA[AZT]GTGTTAAGCATATTGC rslO13O369 TTGTCGAGACTGAGAG[AZG]AGAAGACAAGATTGTT rs4870780 TTGTGAACCAATTGTA[AZC]CCTAACTTAATAGGTA

rs4657942 TTGTGAGCCAGTTAAA[C/T]CTCCTCTCTTTACAAA rsl454408 TTGTTAAGTATG ATGG [C/T] ATATCACCGCTCTTAT rsl538986 TTGTTGTGTTGTGGCC[AA]ACAATATGTGCCATCC rsl2692201 TTGTTGTTTATATGAA[C/T]TAGGCACTGTTTATAC rs292952 TTGTTTGTATCCTTCA[AZC]TGAAATGTACATTCCA rsl863143 TTGTTTTTCCTTTTCA[A/T]CTGCACTAGGGCTGTG rs6950390 TTTAAAACTTCTGCAC[C/T]CACAAAGAGAACAAAA rsl0848533 TTTAAAAGGTATATTA[C/G]AGATCCAACTAGATTC rslO915671 TTTAAAGCTACCTTTA[C/T]GAGATTTTCGTGATAG rsl7708984 GCCCCTCATTCACACC[A/G]GAGTTCTCACTTGAGC rs9515201 TTTACTCGTTGAACGA[A/C]AAAGAGAATGAGCCCT rsl6914091 TTTAGAAAAACAAGAA[AZG]TCAGTGCATGGTAAAT rsl6889712 TTTAGAAACCATGAGA[A/G]GTGAGCATCAGTGGAG rsl2265862 TTTAGAGGTCCACATA[A/G]CTCAGATTTAGAAACT rsl472714 TTTAGTTGAGTATGAA[AZG]AGTAGAGCTAGCAACA rs2139164 TTTATAACTTGAGAAA[A/C]TCTGCTTATTTATAAA rsl6852759 TTTATCAGCAGTTGCA[CZT]AATGAATCGGGGGAAG rs4632016 TTTATGTCTCCCACCA[A/G]TAAI I I I I I I I CTAAA rsl6974298 TTTATTTGATATTTGCtA/GlAGGAGAGTATAAGCAA rslll21111 TTTCAACTCTTAGCAA[A/G]TTATTCTGATAGTTAC rsl358892 TTTCACTGTTAACTAT[C/G]ATAGGTGAGATCATAA rsl7144869 TTTCAGATACAGTACC[C/T]ATATGACATTGATCAT rs269969 TTTCCATTTACTTGGC[A/G]AATAGAACTAATATCC rs3749971 TTTCTAGGCTGTATCA[C/T]CCAGCTACACTTCTTC rs2022349 TTTCTTGTTGCTCCTT[A/G]AAGAAATTATTTTGGG rsll851994 TTTGAGGAATGGTTCCIA/GIAAATGAAATTCAAAGA rs7330992 TTTGATGTATTTGTATtA/TlAACAGTGCTTATTCTT rsl6976271 TTTGCCTGATCCTTTA[CZT]CTTTAAGCAAACCCAT rsl7771216 TTTGCTCAATGGAAAA[AZG]AAGTCTATGTTCACCT rsl554039 TTTGCTGCTGCCTATA[CZT]GAGAAGACCCCAGCTC rs2280005 TTTGGGGGCTGAGCTA[CZG]ATTGCTGGTGGGATTA rsl7008837 TTTGGTGAAAATATCC[CZT]CTACATCGCGTGTGCA rsl7618464 TTTGTCAAGCATGGGG[CZG]ACAGATCCCAATTCAG rs618922 TTTGTGGAGGGCCAAA[CZT]GGTCAAACACATCTTA rs615672 TTTGTGGTTAGGAAAA[CZG]AGAAATAAGAACAACA rs2807213 TTTGTGTATTTAGGTA[CZT]GTATTCAATCTCTTTT rs4305332 TTTGTGTGGTAGACAC[CZT]GAAAAGATAAGAAAAC rslll30137 TTTTAACTTCTCCCAA[CZT]TAAATATTCAGGTAAA rs4877404 TTTTATGAACCACTTC[AZG]GAAAGCTTTCATCAAG rsll706935 TTTTATGTAGATGGAA[CZT]GGAAGGTTTATGTAGG rs4832778 TTTTCCCGTTGAGAAA[AZG]TTCAAGTTCCGAGAGG rsl7146769 TTTTGAAAAATTTAGA[CZT]GGCAGTATTCTTGGTA rsl0826205 TTTTGCAGTTAAATTC[CZT]CATGGTCAAAAATGCA rsl582404 TTTTGCCGTTGCACCT[AZG]AAACTGCAGAAGTTAT rs9384246 TTTTGGCAGATGGTCT[AZG]AACAAAGTAGCTAAAG rs9409080 TnTGTTGCCTATTAA[CZG]TCTGCAGTTGCACCAC

rs2418060 TmTATAAAGTCATA[A/T]CTGGCAATL I I I I I IA rsl7633799 TCCCATCTTGGGAGAA[A/T]ACATGGATGGATAAGT rs4839053 TGAATTGCCTCTTTAT[A/C]ACTTCCGTCCATTTTA rs260445 GAGCTATCCTAACACA[A/G]TAAGAGAGGAAAAGCA rsl387568 TGTTCATTCATACCTA[C/T]AGCGTACAGAACCACT rsl7590125 TGTATATATGCCTTTA[A/C]CTTATCAACTTTGTTT rslO61782 TTTAAGTTTCTCTTTA[A/G]AAATTGCACTGAAGAA rs2889276 CAGAGTCCCTTCTCAT[A/G]AAACTTTCATTCCATG rs3961919 AATGAAGGTTGCCAGCIA/GIGAATACTGAGAGAAAG rs4849148 TCTGGGTTTATTTCCA[C/T]GCTAAATTCTGGACTG rsl0514810 ACCAAGTAAGTAAGGC[A/G]AGAAGGGATTCTGTTT rsl0928662 AACGGCCCTAATCAAG[A/T]CCAGCTTCTTCACAAT rs908919 ATGTTTG CTTCATTCA [A/C]AGTAAATAGTAAACCC rs9287830 CAAGTTAATGGGTTGG[A/G] AATAG ATTAACACGTA rsl865235 CCGGTGAAACAGCGTT[C/T]GGTGGCCACTGACCGG rsl471772 AATTAATTGAGCAAAA[C/G]ATTATCAGTGGATGCT rsl6832223 CCCAACAGCAGTGCAA[A/G]CTCCCATGTATGGAGT rs9733 TCCATGTGTTGTCTCT[A/C]ACTGATTTAGL I I I I I rs231726 AGATGGGTTCTGTATG[A/G]AAAACGGTCCTGGATG rsl7639139 AGCCACAGCACACACT[C/T]AAACCATCATTGTTCA rsl6865055 TTGAAAGGAAGGCACC[A/T]CTTAGAATGTGGATTT rs7603262 ATGCAGCAAATGCTTC[A/C]AATAATAGTAAACTAT rslO498155 GCTGCTGAGTTTACTC[C/G]ATAGCTTTCAAACCTT rsl6993306 GAATTCTGCCATGGAA[A/G]ATGAAACTTTGAAAAG rslO494315 GAGAAAATTATGAAAAtC/GlTGAGACGTGCAATGTT rsl0485759 TGAACACAGCCTAAGA[A/G]TATGGAAACAGAAAGG rs6034280 TATGAATGTTAATGAAtC/ηCAATTTTGCTGATTTA rs7262936 GTCAGTTCACAGGCTA[C/T]GGAACTGTCAAGACCA rs2425883 TGCTGAAI I I I I GCAG [A/G] AAATCACTG AACACAC rs2297248 GATGATCAAAAATATAIA/TJGCCCAGTAGTGCCCAG rsl0494374 GCCTGTGACTTTCCAA[A/C]ATCCATTTAATATGTC rs2032205 AAGCTGTGGTTCCAGA[A/G]TATGATCAAATAATTG rsl2735960 ATTGGAGAGGAACAAAIA/GKAGTATCTGGTGGGTG rs2834819 AGCTTCCCTGAGCTAA[C/T]GTGGTTCTGCTTGTGT rs967445 AACATTTCATTTCTGTIG/TJTTGGGTCACTTTCCTT rsl6856830 TCAGAACACATGATCC[A/G]ACAAGCATAAATGTCC rslO51O483 TGGTATGCAGGCCACC[A/G]ACATATGGCTAATTCA rs4858264 AAGGTAAATAATCACA[A/G]ATCAATAGCATCCTTA rsl508209 AGTCCAGTTCCAAGTTIA/GIGAGGTCCACATTCAAA rsl490271 GAATCGTTTTATGGCT[G/T]AATCATGCTCCTGATC rslO513394 TTCAGAAGTCAACCTT[C/T]AACTGAGAGGCAGGTG rsl320153 ATCACTTTCAAATTCC[A/G]AAAACTGTTCAGAGCC rsll92618 GATCTTTCTCTCTCCA[C/T]TGCTTGGCTCTGCGTT rs7669901 AAAAGTGATAGTAGAAIA/GJTGTTAGGACCTGAGTA rs3775073 AATCTGGTAGACATAA[A/G]GAAAACTGCACTTGGG rs279842 GCTCAGGCAGTTAAGA[C/T]GAGATGAAAGATTTCT

rsl6851641 CAGGCACACAAAGTAC[A/G]GCTCCAAGGTTTTGAT rsl7088864 GTGATGGGAACAAAGAIA/TJGTAAACTAGTATGATT rs2601857 TGAGAACTTGAAAAGAfA/TlGCTAGGAATTAAATAA rsl7034289 TCTL I IC I I I I CTCAG[C/T]CACGCTTGTAGTTAGG rsl0517825 GAAAGCTCCTTTGGTC[A/G]AGAAGAATTAGCTACA rsl026362 GTCmTCATTTTCTC[A/G]CACTGCTGAATAAATA rslO512645 TGGGCTATTTCAGACC[A/G]AACTAAACAGCACAGG rs3911341 TGTCATTTGAAAACCA[C/G]TGCTCTATAACATTTT rs334913 ACTGATGGCCTCTTTAIG/TICACTGTGCTTCTGGAA rsl876143 AGGACACAAAGTAACC[A/G]ATATTTCCATAGACTC rs4141540 GGATCACAGAAAGTCA[C/T]ATACCCAATTTCCTGT rs295543 TTTCTCAGTCCTCTAA[C/G]AGATTAAGGTGATACA rs2059221 ATTCAGAATGTTTGCGIA/GIATCTCAGATAATTGAA rsl6876651 CCCAGTGGGTCACAGTIA/GJACATACAAAGCAGCAG rsl64838 CAACTTCTACAAGGCA[A/G]ATTTACTGATCTTTAT rsl0494954 TGTCACAACAATCTTA[C/T]GCATTAGGTGCTATTG rs4836328 CCTACACACAAACTCA[A/G]TCACTATCCCAGACTA rs7731706 AGCTCTAATCACCATA[A/C]AAAGCATCAAGTTTTC rs371486 GTTACACCATATGTTA[A/G]GCAATGGAGGCAAAAC rs9466585 AGGGTACCACGTTCAA[C/T]TCCAAAGTCGGCTTCA rs579996 AGCTTCACAAACACAA[C/T]TACCTGTTACTAAAAT rs7773913 TGAATGTGAAGAAACA[C/T]TGATTGTACACGTAAC rsl2660860 GCTAGAATAACTGTAA[A/G]TGATGCACTGTGGGAC rs9296009 GTAAAATACAGGTTGGlA/ηAAAGCATTTG ATTAGC rs4714586 GCCCTGGGGATCAGTAtA/G]GAAGCCCGACGCATAG rslO485318 CCTGTTTTCAGCAAAA[A/G]GTATAATTCTGTATCA rsl0484879 TGAAGTCAAACATTCA[A/C]ATTGGAAGAAAGAGCT rs3799935 AGGTTGAAGAGGTACGIC/TJAGGAGACAATTGCAGG rsl938088 TGATAGCTGTTTCTGA[A/G]GAAATTAACCTTAGGA rs2204478 CATTC ATG AG GATTAG [C/G] ACTTGGTATAG AACAT rslO244178 CACTATTAGAAAGAGA[C/T]GGAGCTATGATTTAAC rs2098375 CTAGCCTTCCTGATGA[C/T]GACTTTTCACAGTAAT rsl7132813 GAATTACCTCGGATCAIC/TIGGTCAAATCTTACACC rs595846 CAACCGCAGATCCATA[A/C]AAATTCTATCCTTGAT rsl342068 CTAGTTATGCAAAGTA[C/T]TACCACTGGGGAAAGC rsl7842722 GTGCTCTATACTCATA[C/G]AACTGGCAATATAATT rsl7722395 GTTATTGCTGATGCAC[C/T]GGTGTGACTTCTCAAT rs7793555 TAAATGATGCAGTTGA[A/G]GTAACCATGGACTAGT rs879428 CATTTAAAACAGTGTA[C/T]GTCAGATTTGTGTACC rs2189772 TTCCTGTAATTCTTCC[C/T]ACTGCTGTTGTTGAGC rsl3243734 ATGTTTGAAAAAAGGCIC/TlAAAGGTCAGATTGTGT rs4726931 GGCTTTAAGTAGAAGAμ/GlAAGTACATTGATAACA rsl7738513 TCTAGAGGCTAACCCA[G/T]CTGGACTCTGGAGGAA rsl368538 ACTATAACTTTGGTAC[A/G]AGGATCTTACTGTTTC rsl446687 GGCTGTCATTCCTACA[A/G]GCCAGTATAATAACAC rs2249244 TTCAATGAAGATGGAAtA/GlAAGTAAAAGCTAGTCA

rsl436024 AGATTATGTGACCTAAIC/TJGTTGGTTAATGAGAAA rsl367972 CCAACATCTTAACTCA[C/T]TACAGCTTCAAGTCCA rsl7482603 TTAATAI I I I I GATTC[A/G]CCAATTAGACCATAAA rs885046 CTTCCACTGGACAAGA[A/T]GGCAGATGTTGTCACT rslO752138 GCTAACGTTTGGGTCA[C/T]AGTATATAG I I I I IAA rsl355060 TACCAAATCCAGAAAT[C/T]ATTTAACACAGATGTA rs2220182 CATACTGCCTTTGGTA[C/T]AGTAGGTAGATAGCCA rsl332199 AATGGGCGCTCAAGTA[C/T]CTGGGCTCATAACTGT rsl339140 CTGCATTAAAGGTTGA[G/T]TTTTCCTTAGTGCTCA rsl412387 CTGACTGTATTCTGTA[A/G]CTGAGTCAGAGGGTGC rsl342022 TGAGCTTCTGAAATGC[A/G]AAACTATGGATTAATT rsl6916797 AAAAATCTCTTTGTAC[A/C]GGTCAGCATGGTGTGG rs9314750 CCTCTGCTTAACCGGA[A/G]CGGCCGAACAGCGCAG . rs952834 ATAAACGAAAATTAAA[A/C]GAGAGTTCACGGCCTA rsll793717 CTCAGGTGGAAACGAA[G/T]GCGCCCCGTGGCAGGC rs4743638 TTAAGGTAAATGATGAIA/CJAACTGCAAAAGAGTGA rsl0521035 CTTCAAGTTAAGAAAT[G/T]ATGGCATGACCTGAGT rs999471 GACAGTGCAGGTACGG[C/T]AATATTTCTGCACTCA rs2017419 TGGCCTGGAAAGAACA[G/T]CTACAGTATGGCCACA rs306770 TCTTGTCTGATTCTAA[C/T]ACCTATACrCTTTCCA rsl420770 TTATGATGATGGTAAT[A/G]ATAACAGCCAACATTT rs6588196 TCACATGTATGGCAAAIA/GJTTGTATGGAGTTCTAA rs2297492 GTGTTGTCTCCTAAAA[C/T]AGGACTGTCTTGCCAG rs6587622 AACTGGTTGCTCTTCA[C/T]TCATGGTCAAGGAGAG rs7076242 TGATCATTGTTCTGGT[A/C]AATGCTCCAGCCGCTC rs6687797 AAAATTGGTAGAATGT[A/T]AAATCCTTGACAGCCT rsl202527 AGAATTTTGTTTCTCA[A/G]ACTGCCTCTCTCACCC rsl954342 AGTCCACCTTTTAGTA[A/C]GTGCTTAGATATTCAG rs7076249 CTCAGTGTCATAGTTA[C/T]CAAGGGGCAATGCCAA rsll816586 AGAGTTACGAATTTCT[A/G]ACTCAGTCTTTGAGAG rsl473467 TTTAGAATACAGTGAAIA/GITGTGAAGGAATGATTT rs4533067 CAAAATTAGTCATACT[C/T]AGGTTGAAAGAAAAGT rsl344967 TTTGATCTTCCTCTCA[A/G]TAATTTGACATCAAAC rs4933622 GCCAGAACTGGTTGTA[C/T]GTCTATCTTACCATAT rs2325197 CACCCTCCATCGGTAA[C/G]AAGATCACCAGGCATT rsl7325644 TGGTAACAAACAGAAA[C/T]GTGTGAAATTGTTCAG rs7336035 TGAGATAAAAAAGAAA[C/G]GATAATTGAAGCTGGC rs7194620 GCTCTGAGTU I I I I C[A/C]AACAACTGGGGAAAGT rsl0884326 GCTCTGGAGCCATTTC[C/T]ACACTGACTGGAACCA rsl925383 TCACATGAAACAAAGCIA/GJAGAATCAGAGAACAAA rs4496207 TTCATTTATTCCACAG [A/GJCATTTCTAAAC ACCTA rslll95130 GCCATACAACAGAATC[A/G]CTCGTGCTGCTTTCCA rs7507031 AGCCGAGAAGCAGGAAIA/GJTGACTCCACCCAGCAT rs607840 TAGTGAAAAGCACCCC[C/T]ATCTATTCAGTTGTCC rs2074321 TGCCTTCTATTTTATA[A/G]GTAATCTCAACAGCAG rs7425670 ATAGGATATCAAAGAA[CZT]GAGTGTGAATCAGCTA

rs923031 ACCCAGCTCTTTG AAAIG/TIATAACTGATAACTAGT rs726643 GGGTGGCTCGCAAGGA[G/T]GGTGGATTAGTTTCCT rsl520884 TTATTTGTTTCTCTTG [C/T] AATGCTTAATATTGGG rsl023785 TTCTCTCATGTCTGAC[A/C]GGTAAGACAGGGCACA rs7627651 TAAAAACCCTAGTGAC[C/T]CCAGCAAATTAGAAGT rs932503 CγGATTACATTGTCGC[A/G]CCAATTTTGTAGGTCA rs4246697 GAGATGCTGAATAAAG[A/G]CAAGCGATGATTTCTT rs2301718 CACAGGAAACTTCCCA[C/T]GACATATTAAAATGGA rs7358511 TATTCACATAAGCAAG[A/C]AAACTAAACTATTCAT rsl6938073 AAGTTTCAGGTCTCTC[A/G]AATGATAATGATGATC rs4407639 GGCTTTGTTCTTAGCA[A/G]TACAGTTTAAGCAATT rs726520 TTTCCTAGGCACTATC[A/G]AATTGCATTCCATGGA rsl7103991 ATTCAGTCACCAGATC[A/G]CTTTCACCACCTTGTT rs962910 GAATGGTAAATTGATCIA/ηCTGATTAATGGAAAGC rs7768021 TATTTTTATACAACAA[A/G]TTCCCACTCCTAACAT rs2496655 CAGGCCACCAGCTATC[A/G]AGGGCTAGGAAAGGGT rs2681055 AATGTGACCCTTTGCC[C/T]CAGATAGCTTCAGAAG rs3847504 TACACACAGCATATAT[A/C]AACTTTGAAATGTATT rs4368946 AGATTAGAAGGAAATA[C/T]CAATAAAGCCAAAGTT rs214635 GACTCGAACGCAGGTA[A/G]AGGACAGGGAGAGTTC rsl7103836 AAGATGACAGGTGTCC[A/G]GCAAATTAAACTCTTA rsl0502069 GTTTAAATATCTCTTA [C/T] CTG G AC AATAAC AATG rs2205254 GCTTTAAAACTTGATC[C/T]GAATTTAGAAGCAAAA rs414663 CTGATTAACCAGCAGA[A/G]CACCTAGCATGATGCC rsl97586 ATGTTGACTATTTTCA[A/G]ATGCACATAATCTCTT rs2824671 GTTAGCAAATGTACTA[C/T]AATGCAAACCATCTTT rs2825063 GAAATGCGCATTCAGG[A/C]AAAAAACAGTATTTGT rs41423945 ATAAAATCAAATCTAC[C/G]CTGCCACTTTTATATC rs2830524 AGAATGCGGAAATGGAIG/ηGTAGGGATGCCTATTT rsll53257 TTCAGTCCTTTTGTAA[C/T]AAAAATGCAGTCTCTC rs2832159 AGCAGTCCTTACTCCA[C/T]GGATCATTTAGTTTAC rsl7666683 ATACTCACAGTGCAGA[G/T]CTAGAAATGTCTGTGC rs2833656 ACAGATGGTTTGTGGA[C/T]AAATGATCACTAGGAA rs979393 ACAGGTCAACTTGAGA[G/T]G I I I I IAATATGCTTA rsl013061 CAAGTAAAAAGCAAAA[C/T]TGAACTAAAGGCAAGG rs2834639 TCACCACTAACCTCAA[C/T]TCTACCTTATCCCTAA rs2836706 TTGTCTTAACCAAAAA [C/T] GTG ATGTTCCC ACATG rs2019147 TAATGGCCATACTTGC[A/C]GAAATAAGGTGGTGGT rs7275482 ATTCAGCCGCTCCTAA[A/G]TAGGTGGCCAGATTGT rs4148137 CCTGAACTCTGTGACA[A/G]CACGTCTTAGACTTTA rs9653818 TTGATGTCATCTGTGG[A/C]ACTTTGCAGCTTGATC rs2396450 AAAAACTGCACATTTA[A/T]CCCAAACTCAGGTATG rs798121 AAAAACTGCCAAACATIA/GJAAAACCAGACCAGAAT rsll008540 AAAAATACTTAAGATA[C/T]GAACCTCTCAGATTTT rsl6832766 AAAACCAACCCGAACA[A/G]TACAATGATTTCATCC rs2027815 AAAACCAGATATAAAC[C/T]GAACTAAGTATGCCAA

rs2865195 AAAACTTCATTGCTTC[C/T]ATGGAGTCTTTAGGGA rs2885857 AAAAGAATTGAAGCTA[C/T]CTATATTACGTCCTAT rs7156849 AAAAGATGGTGAAGTAIA/GJGGACCAGAAAACAGGG rs4559098 AAAAGTACTG GACCCG [G/T] AATCAG GTGTCCTTCC rs6829788 AAAATCTCTCCCTGCT[C/G]AAATGTAACCATTAAT rs2938015 AAMTGTCCTAATTCT[A/G]AAAATGATTTATCAGG rs518457 AAACAAACCAATATGC[A/G]ATCAGCAGGTATAACA rs33992134 AAACACCCAGGATGGA[A/G]ACATTACACTTGAAAA rs41443951 AAACAGCAGTGAGAAC[A/C]ATTGCAACACAAAAAC rs601225 AAACATACTTGCTAGA[C/T]ACTGGTTCAACTATGA rsl3334604 AAACTATCATTGTTTAIA/GIGTAGAGGAGGTTCAAT rsl6842428 AAACTGGTCAGAGGCA[C/G]GATTGGCATAGCATGG rsl0077678 AAAGACCATTATGCCA[C/G]AGATAAAATAAGTTGC rsl0045073 AAAGAGGAGAAAGACAIC/TJGGATGTGAACTTGGTT rsl7369045 AAAGCAGGTAATGTCA[C/T]AAAGGATTTGCCATTT rs2416399 AAAGCTCAATTCGAAC[C/G]GGAATAAACACAGACC rsl449551 AAAGCTTATTGAAACT[C/G]AATGCCACTTTCAGAT rs4565081 AAAGGCAAATTTTGCA[C/T]TCAAAAACAGAAATGC rs265014 AAAGGGAAGCGGAACA[C/T]GATTTCATGGCAATCA rs2985763 AAAGGGTCAAACCTTA[C/T]AGTGCTCTCATATCCT rs2108593 AAAGGTGGAAACAGCqC/GjAAATTGATGGAAGAAT rs7350731 AAAGTTTTTCTACTCA[A/G]TGAACTGTAAACTCAT rsl7215232 AAATAG CTAC AAATTC [A/G] C ATG CTTTG G CTTTTG rsl944037 AAATCACTATGGTTAA[C/G]AACTTAGTACCCCCTG rs901505 AAATCAGCATTCATGC[A/G]CTGTCTTAGATTGTAG rs7650856 AAATCGTCATGAAAGC[A/G]ATCAAAAGTATCTCAT rs2055628 AAATCTTTACCTGTCC[A/C]AACATTGCAAAGGCAT rsll052436 AAATGAAAAGGTATGAIA/GJCAATGTTGAAAAAAAT rs9374305 AAATGGCAGGAAAGAAIC/TJGCAATGGATAAATGTA rs6717050 AAATGTAAGTTTGGAAIA/GIGAAAGATAATTGACTT rsl0219509 AAATGTAGAGAAAAACfA/GjATCCAGGAAGGAGAAG rs4937432 AAATTCTCCCAATATC[C/T] CCAGTTC AGTTTCCTG rsl0267258 AACAACACAAAAGGCA[A/G]AACAATGTTATGCTTA rsl2156500 AACAACATGTAAACAC [A/G] GTCATTG G AGTG ATAT rs4419538 AACAACTGCTCAAGAA[C/T]GATGTTAACAAAAATT rs3923586 AACAAGGTTGTGAAAA[A/G]AGTGAAAATCTGCCAA rs348900 AACACTGAGGATGTAA[C/T]GGAGTTTTCACAAGTT rsl484642 AACAGAGTCTCCGTCA[C/G]TCAGAAGCTAGAGGCA rs681828 AACAGTAAAGCAACAA[C/T]GCAGTAAAAATGAAAA rs983540 AACATTCAGTTTCCAA[C/T]GAATTTCATACACAGA rsl0997517 AACCAACAAATCTGAA[C/T]CAGACCTTAAACTATG rsl7797971 AACCAGACGTCGAAGG[A/C]AGGATAGTATTTGAAT rs4851454 AACCAGCCACTGGACA[A/C]CTTCAGACACAGAACA rs2237330 AACCCAGATTCTGGCA[C/T]ATAACAGACCCTTGCT rs4682110 AACCTCTCAACTCTAA[C/T]CAATTAGCTTTTCTTA rs859157 TGCATTGTTGTAATTC[A/G]CATCATGTTTGCATCT

rs9575249 AACTAAAAGCTTTGTA[C/T]AACGCGTGCTGCTATG rs7102988 AACTAACTCCACAGAA[G/T]AAATAAAATGGCTCAT rs232621 AACrAAGGTTATTTGA[G/T]AATTCCTGGGCCACTG rsl7040633 AACTACTGTGAGTCCA[A/T]GCCCTAAGTCCTATCA rsl678094 AACTGACAGAATTTTAIC/TlGGAGAAATGAAGAAAA rsl7075631 AACTGCAGTCCCTTGC[A/G]GATCGAGGTTTCTGGT rslO26345 AACTTGGGAAGTGATA[C/T]GGAGAGAGATGACCTT rsl6932246 ATAATAGCATTTGAAA[A/G]GCTCATTAAATAGAAC rsl7487711 AACTTTCCTCAACAGA[G/T]AATAATAGGCAATCAT rsl2538450 AAGAAATAAACAGGTA[AZC]AAGCTCATAAAAATAG rs9585895 AAGAGACAAGAGTGAA[C/T]ATGGACTATGGTGACC rs605026 AAGAGAGAGAGGGGGA[AZT]GGTATTATGTTCTTTT rs2164300 AAGAGAGGATTGATAC[A/G]GGCCTCATGTTCTTGC rsl6931391 AAGCAAGGAGCTCCAA[A/G]AACCTTCACACTTGAA rs4149253 AAGCATGTCTCTTACCIC/TJGCTTCACAGACTTTAT rsll711461 AAGCCAAGAACCTGAC[C/T]GTATTCAGCCTCCAAC rsllll0522 AAGCCCTCTGCAACCT[GZT]ACTTCAGTCTACATTT rs9486619 AAGCTACATTTGTGAA[C/G]TGAGGTTGGTAATTGC rsllO52835 TTTATCCTTCATTTGC[A/G]CTCATGCTCTTTGTTT rs878074 AAGGACAGAAGGGACC[AZG]GACCGCTGGATGCAAC rsl881573 AAGGAGAGACGAACAA[CZT]GACAAAACCTCAGAGA rs2485604 AAGGCAGTGGCTGGCA[C/G]GATTAAATAAAGGCTA rs490609 AAGGCTGAAGAAATTC[C/T]GAAAGACCTATAGCGT rs9399726 AAGGGCATCAGTGGAA[AZG]CGTATGGAAAGTTTAT rsl7005319 AAGGGTCAGTAAGTAG[AZG]AGTAACAGAGGCAATG rs9331341 AAGGTAGACAGAGAGA[CZT]GCGTGTGAAAAAGAGC rs4245855 AAGGTAGTCTGGGATC[AZG]AACAAGGGAATAGAAG rs9635390 AAGGTATCCTGAGTCT[CZT]ACCGTATCTGCTCCAT rsll721812 AAGGTCTCCTTGGCCA[A/G]TAAGAGTCTGTTCAGT rs436124 AAGGTGATGAAGAGCA[CZT]GGAGTAAATAAAGAAG rsl2498466 AAGTAGGTAGATTTGA[CZT]GATGGAAAAAGAAGGG rs4843415 AAGTCAGATTGTGAAAIA/CICTTTGCTTCAACAGTC rsl0904949 AAGTGATCACTTTCAAIC/TlTCAAGAATGACTTATA rs7000771 AATAAAAGAATGTTAT[AZG]AAGCTTCAGATGTCAT rs7953173 AGTGTAAAAATATGAC[AZG]GTACATACGTATGAAA rs4904512 AATAACACAGACTCAA[AZG]TACAGCGAATAACTTT rsl0196226 AATAAGAGGGTACTCA[CZT]TGAAATCACAGGATTG rs2777317 AATAATGTATGCTACA[AZG]CACAAAGCATTTATAT rs6745170 AATAGAAAATCTTTTA[CZG]CAACTGCGCCATAAAT rsll984152 AATAGCACTTGAATAA[CZT]TCCCTCTGATGTGTTC rs7316983 AATCATACTTTAAGCC[CZT]ATCCCCTTACCTGTTT rsl6927318 AATCCAGATCAGCTTA[CZT]GTTTTAGATGCTAGGA rsl7071854 AATCCATCATTCTGTA[CZT]GTTCAGCCTATCTCCT rsl3012482 AATCGACTGGACGAAG[CZG]CTTCATGAATGATCCA rs7299038 AATCTCAG G CATAGTG [AZG]ATAAAACTCATTCCAG rsll033408 AATCTGGGTAACAGAA[CZG]AGAATGCCTGAGCCTC

rs4844714 AATGAATACTAATGAC[A/G]ACATGGATGCATCTCA rsl7733311 AATGACAACCTTGCAT[C/T]AAGACAGCGTTTCTAC rs7834090 AATGGGATTTAAG AGG [C/T] CATCTAACC AAAGTCT rs9600298 AATGTCTTGTGGTCTA[A/T]TACCCTTTAATTTCCA rs9436185 TCCTGAGCATCTCTCA[C/T]ATCTGGGTGATAAGAG rslO741165 AATTATGACATTACAA[A/C]AGTTAGGCCATATCTG rsll674150 AATTATTCACCAAATA[C/T]GACTAAGGAAAGTTAC rs907344 AGGATTTGAGTAGCAA[A/T]CACC I I C I I I I I GTCT rslll49173 AATTCATAAGCTTAGA[C/T]ATAGAAGGGGTACCAT rsl7048768 AATTCTCATTGTATCA[C/T]ATCATCACACTCAGAA rsl2143885 AATTCmGAAACCTC[A/G]AGTCTTTTCCCTCTTG rsl2236277 AATTGACGTAAATAGqA/ηGATAGTACATTTTATT rs4702052 AATTGCATGCCATTCC[A/G]AGTAGTGTAATGAAAT rs41482544 AATTGG ATTATTTGGG [A/T] ATAGGCCACAATCTGG rsl0797534 AATTTCACAAGTTCCT[A/T]AAGCTCACTGAGTCCT rs9458813 AATπCATπCGGATG[C/T]AGGTCTCCTTTGCAAA rs519627 AATTTGGACAAGGTCAIA/GITGAACGTCCTTGAGCC rs9469220 AATπTATATTTCTAC[C/T]GGCAGTTTGAATGGTA rs4803565 AATTTTTAAGTCTTCC[C/T]AGATGCTACTAATGTG rsl0506446 AAGAAAAGCAAGTCAA[A/T]TTAATCAATCCCCTTC rsl3240893 ACAAAGACACCAATAA[C/T]GCACAATGGGAAAATT rs8000509 ACAAAGTCAGGGGACA[C/T]ATTTAGCAGGATCTTT rs749810 ACAAAGTGCTAGGTGA[C/T]AGTGAGGCCAAGGAAA rs2962074 ACAAATCAATCTGTAA[C/T]AGGCAAGAAGATCTAC rs6915699 ACAACTAAAGGCAATAIG/TJCACGTAAAATAGGATT rs3910044 ACAAGCTATTTGCTAA[C/T]GTGGTTGTGCCATTTT rsll769827 ACAATCCAAAATCATA[C/T]ACTCGGCCGGGTGCAG rsl3213193 ACAATTCTAAGGGTTC[C/G]AAAATGAATTGTGTGG rs7105596 ACACACATATCTAATC[A/G] CACCCA I I I I I GTCTT rs6488950 ACACACATGACCACTA[C/T]GCTGTTTGCTGAGGGA rsl7117244 ACACAGCCTAATAACC[A/T]GAACCAATTGAGAAAA rsl2092798 ACACAGGGATTCGAAA[C/T]GGATCGCCTCACTGTG rsl0804563 ACACCAATTCATATAA[C/T]GGAGTGCTAGACAGCT rsl993761 ACACTTCAGAGTGACC[C/T]AAAACTAGAAAACTGG rs6090978 ACAGAATGTGGAATTA[C/T]CTGGTGGCTATCGTCC rsl7096082 ACAGAGTAGCCATAATIA/GJAACTAAATACTAGCTA rs6663006 ACAGATAACCACTGTC[A/G]CTTATATAGGTTCTCT rs9481068 ACAGCAGGTACACATA[C/T]GGCTCTTCGGGAATCG rsl2504603 ACAGTAACAACCTTTC[A/G]CAGTGCAGCCCGGCTG rs3095465 ACAGTAGCTTTGGGAA[C/T]GTTGAGAACAGGAAGC rsl869275 ACAGTG I I I I I ATTGG [C/T] ATCTGAAAGCATCTGG rs239865 ACAGTTAGGATAGTCAtA/GJGGAAGTATGGTACTGG rsl893146 ACAGTTCTCCTGACTC[A/G]ATTCTATTTCCTCTCT rs2466296 ACAGTTTTCAAATGAC[C/T]GTCACTAGTGTTCCTG rsl2529820 ACATATAGCTAGTGCA[C/T]AACGGAAGTTAGCTCT rsl0506697 TACGTTACTTAGCTTG [A/G] ATACATAATAAGAATT

rsl881941 ACATGCTGAGATTTCT[A/T]AAAAAGTGGGCCTTTA rs7279678 ACATGGTCATATCTAA[C/T]ATCAACCGGGTGTAGA rsl0239703 ACATTTGTGAATATCA[A/G]CTCTGTTCTTGGCATC rs329384 ACCAACCAATTCTCCA[A/T]TGCCACCTGGGTGCCC rs503506 ACCATACAACTTAGAA[CZT]TCAACTACACTTGAAC rsl2649063 ACCATTGCTTAGAGAA[A/G]CTGTCATCACTCCTGC rsll756951 ACCCAATGCTCTTCAA[C/T]TTATGAATGGATAAAC rsl0818918 ACCCAGACTCCTGACC[A/G]GCAAAAACCGCGAGAT rs4433091 ACCCCTGCGTCTTTAA[C/T]GTAGATGCCTAAACTG rsl0746988 ACCCTCAAGTTTATGA[A/T]CTGGGCTTGCCAATGA rs9575699 ACCTACAGAGAATCTA[A/C]GGAATCAAGTGCATTA rs2305234 ACCTACTACTTTTCCA[C/T]ACAGAGTCAATCAAAT rs4713859 ACCTCTTAGCATACCA[AZG]TAAAACACATTTTGTT rsll258682 ACCTGCCTGGGTCCAC[AZG]CCTCATCGTCTACACT rsl2295814 ACCTGGAAACATATGA[C/G]CTTTTAGTGTATGATG rs758758 ACCTTTATACCTCAGT[C/T]AAGTGCAGATGAATAA rs7556844 ACGTGCATGTGAAATA[G/T]TAAGAACGCGCTGATG rs2884078 ACTAAAACTCTCAGAA[A/C]TCTCCCATCAATTTTG rsl2540244 ACTAATTCATACTTTC[A/G]CCAATGGAGTATAAAT rs749128 ACTACAATTGTCTGCT[A/G]AACAAACTACAGAGGA rs7897488 ACTACCGACTTGGAGA[G/T]GAAAAATAGCTTTGTC rsl7063003 ACTACCTTTCTGTTGA[C/T]GGATTGATGAGACTGA rs6800337 ACTACTATGAAAAGAC[C/T]GCACGTGACAGAATTG rs9546178 ACTATAATCTCATTGA[C/T]GGCAGCTGTATTAGTC rs2035882 ACTCCAAATGGTTCAA[A/G]TAAGACTTCCAATACC rs7610518 ACTCCATAGAAAGCCA[C/T]GTGAAGCTTTTCATAA rs292302 ACTCCCCTGCATGGAT[C/T]ATATCAGCTGATAAGC rslO99379O ACTCTGAGAAGGACTC[G/T]GAAGAGGTGACACGAG rs2736463 ACTCTGTGATCTCGGA[C/T]GATAATTTAATTATGG rs6588005 ACTCTTAACATAGCAA[A/C]CCAAGAGGTAGGCGTT rs6843147 ACTGAGAACTTCTAAT[A/G]ACATCACACTTAAAGC rs2880857 ACTGAGGGATGGCCTC[A/G]CTCAAAATGGTGGTCT rsl7816620 ACTGAGTGGAATATAG[A/T]CAGGTTAATTGCCCTA rsl0986181 ACTGATGATTTTCTCC[A/G]AGAAGCTCTCCTTTTC rsl6869650 ACTGATGTGTTTTCTC[A/G]AGATGCATATGGAAAG rs9931088 ACTGCAAGGATGACAAIC/TIGGGTTGTGTAAGGTGG rs6775553 ACTGCTGTTGCTGATA[CZT]CCCCTTCCTTTTGCTC rs821804 ACTGGAAACGCTGAAGIA/GIATTTTATTTTATTTTA rsl924378 ACTGGACTAAGTCACA[AZC]AACAGTTCAGTCATAT rs415929 ACTGGATCTGGGGGTA[CZT]GTGGCCAGACACACCC rs7758978 ACTGTGAAGTTTTCCA[CZG]AAGCTAAGTGACAAGT rs991964 ACTGTGCCTGACTTGG[AZG]ATGGATGACTTGGAGA rs34561430 ACTGTTGGTGTGAAGA[CZT]GTAATTGACAGTCATA rs2305737 ACTGTTTGC I I I I I IA[AZC]AATCATGTGGACACAA rsl7712022 ACTTCTCAAGCAGGTA[AZT]GCGTTATCTCCTCAAC rsl7023015 ACTTGAGGCTACATAA[AZG]GAAGTACAAAAATGTA

rsl518922 ACTTGATAGGTTTTAC[A/G]GACTTGCTATACATTG rsl7243773 ACTTGGAGCCCAGTAA[C/T]GGAAGAI I I I IATGAT rsl979755 ACTTGGCTGATTATAA[C/G]AATATCTTTACCCAGA rs8087329 ACTTGTTAAAAGGAAA[A/G]TATCATCTCCACAAAT rs2131795 ACTTTATTGTGGTAAC[A/G]CTTTCATCCAAATATA rs3744749 ACTTTCAAATAGAAAA[C/T]GAAACTGGGCATCTCT rsl0118645 AGAAAAGAAATGπCA[C/T]GTAATTGAGTATCTAA rs4417767 AGAAAAGAATCCATTA[A/C]GTTTAGCAACTGAAGC rs6736714 AGAAAGCTATGTCTGAIA/GlTATTGGAGTGATAAAG rsl7770565 AGAAATCAGGTTGTAC[A/C]CTAATAGGACGATCAC rs7555212 AGAACACAACACATGA[A/G]GCAATTGGGCCACCAT rs2133294 ACTGTGTAAGCCTTCA[G/T] ACATTG AGTCCAATCA rsllO63649 AGAAGCAAGACCAAAA[A/C]TTAGGCTCCCAATTTT rs754691 AGAATCTCAAATGATG[C/T]CACAAGGACCCTGTCC rsl3194825 AGACACGCTCCAGGGA[C/G]GTtTCTATAAAGTGGC rs729964 AGACTGACCACTCTGC[A/G]AGAAAAAAATGGTACC rsl6992637 AG ACTTTTG CTTCATG [C/T]CACTTATG AACATATT rs207876 AGAGAAAACAGTATCA[A/G]TAGAAGTCTGGAGTGC rsl0892909 AGAGAACCTGGTTCAA[A/G]CTCAATTGCAATCTTT rsllO37479 AGAGAGTCACTCAGGA[A/G]TACCTAGAGTTGGTTT rs2367429 AGAGCCTAGCATCTAC[C/T]GATCACTCACAAGATG rs7292688 AGAGCTAACATACCTG[A/G]CAACCCGGTAAATAAA rs2372531 AGAGGAAAATCCATGC[A/G]AAGTCACAGCAAGAAG rs7072007 AGAGGAAATAAAATAAtA/GjCAGTTCTGTGGTGAAG rs34082346 AGAGTAATAACTGGGAfC/ηGATAAAAGGAAGATAA rsl2649108 AGAGTATGATGATTGA[C/T]GGACCATTGCATATTC rsl7823433 AGAGTCAATGTGAAAG[G/T]CTATTCAACGCACTCC rsl6871026 AGAGTCATAGAACAAGIA/GJCACATGGGAGTATGGT rs6699224 AGATACATTAGTTCCA[C/T]CTGAAAAGGCAAGATA rsl386037 ATGACTGCACAAAGAT[A/G]CTAATAACAAACAGAG rs7022870 AGATATGGGTGTGTCA[A/G]TCCTCCGTGGCGCACT rsl023681 AGATATTGATGACTTC[C/T]GAACGGCACAAAAAGA rs2064754 AGATCAAATTGGGAAA[A/C]ATTGACTTCTTAACAA rsl7673686 AGATCGATATAAAAGA[C/T]GGTAACGGCCGGGCGC rsllO32755 AGATCTAGGGCTGCCA[C/T]GAATGGTTGTGTAGTG rsl7782421 AGATGAACATTGCAAG[C/T]AGATGAACAGGTGAAC rslll32004 AGATGGGTTTTGGCCA[G/T]GGAAGTGACATAATCT rsl6915248 AGATGGTACAAGTGTAtA/GlAATTGACTGTTAGTAC rsllO33971 AGATGGTCATCTTGTA[C/T]AGTCTCACTGGAATTC rsl6994357 AGATTCCTGCCTGAAA[A/G]AGGGTGACATCTGTCC rsl929877 AG ATTG G CCTACTCTG [A/G] ATATGTCCTATAAATG rsl7581484 AGATTTACATGGAAGA[C/T]GAAGCAACTGATTCAC rsll955772 AGCAAACTCTATTAAC[C/T]GAATCTTGTTTCTGGC rsl482058 AGCAATACCAAATGTGIA/GJAACAAATCCCAGTGGT rs7829132 AGCACAGGCCTAGCTA[C/T]TACTTGAAGAAGCCCC rs2867598 AGCACCATTTAAAAAC[A/G]CTATTTTATTGCTGTG

rsl6982162 AGCACTTCCCGTCCTA[C/G] AGTAG ACCATCCCTTG rs545114 AGCCACATCTGGGCAA[C/T]AGAAGTGCGCCAAAAG rs5752553 AGCCACGTACCTATGC[A/G]CTCACATCTAACAAGT rsl7228508 AGCCATTAAGAAATTAIC/TIGAGTTGAAGATTAGCT rs958646 AGCCTTCAAATAAGAAIC/GIATTGAGAAGAGTTGGG rs442170 AGCGATCACGTACCGA[CZG]TATTGACTTGGCTCAG rs6587138 AGCTACAGGAGAAGGA[CZT]CAGCGGCCATGAGAGT rs3748748 AGCTGCTTCCTGCAGA[CZT]AGACTAGACTCCTTTC rsl7622740 AGCTTCTATTCTCCCA[CZT]GTTGAGCTTCAGAGAC rsl3159699 AGGAAAACTGTCCATT[CZG]AAGAAAAGGTCAATTT rslO914555 AGGAACAGAGGGTTCC[CZT]CCCCAACAGTGAGCAT rs7618408 AGGAATCATTGTTACA[AZC]GAAAGTTCTGGTTTGG rs598126 AGGACCTCAGACATAC[AZG]GAGAATGAAGAGGACA rsl904775 AGGACTTTCAGCCATC[CZG]CCTTAGACTCAAACAA rsl0246702 AGGAGCTCATCTAGGA[AZG]GAGAGTACAGGTAACA rs6509074 AGGAGCTCTCACATAA[CZT]GAATGAAGAACTTGAA rs2075094 AGGATTCAGCTGTCCA[AZC]GTCAACTCAAATAATC rs4805419 AGGATTTGGGCAGAAA[CZT]TAACTCTGCGATTGAA rs4842999 AGGCAAAGATTGTGCA[CZT]GTTGAACTGGAATGAG rsl465817 AGGCAACTCGCAAAGA[AZT]GAGATGGAAGAAGGCA rs7000768 AGGCAGGTGCTATTTC[CZT]ACCAGGACTCATAAAA rs7999201 CAACATTTCACATCTG [CZT]AGTTAACTTGAAGCAG rsl0822779 AGGCCCCAAAAGTGAA[CZT]GCTTTCTGTGAATATT rsl2379804 AGGCTAAGAGACTGAG[CZG]ATTCTTATTCAAAAGA rsl3077136 AGGCTAAGCTTCCTGA[GZT]AGTTACTTCAATCATA rs2900095 AGGCTCAGAAAATCTA[AZG]TAAATCTGTCTGAGGC rs6085231 AGGCTGGAAAGAAACA[CZT]ATTTGCTCCCCTGTCT rsl483661 AGGCTTAGACTTGCAC[CZT]AAGGCTCCATCAGGCC rslO17251O AGGGAAGTACCAAACA[AZG]TAGAACCACGCTCTAA rsl2517255 AGGGAGACTTCTGAGT[CZG]ACGACTTTCCATGCTT rsl2309038 AGGGCTTAATTAAATA[CZT]GTGGTTGGTGAAGATT rs8074124 AGGGTCAGTTTATGTA[CZT]GTAAATTGGTCATTCC rs7440912 AGGTATGAGATGCTTA[AZG]CCAAGATTTTATGATT rsl552859 AGGTATGGTAGCACAA[GZT]ACTGGTTGTTCTGTAC rsl7611274 AGGTCTCATGGAGGTA[AZG]CCAGATATTTTCCATT rs6510896 AGGTCTGTAGCCTGAC[AZG]GACAGTTTCTCTTCTC rsl7131376 AGGTGACCTGTGAAAA[CZT]AGACTCCTTCCAGTGA rs27011 AGGTGGTTTGCCGAGC[AZG]CCAGACTGTTGTAGCA rs2966606 AGGTTTGTAGTTGTTA[CZT]GGCAGTGCTAAGAAAC rs9479058 AGTAATAGCAGCAAGA[AZT]GGATGAGGATGTTGAA rsll257429 AGTACCATCTAAGCCA[CZT]GTAAGTATTAACACTT rs4417998 AGTAGAATTTAAGAGC[AZG]CAAGAATCATATTAGA rs964266 AGTAGCTTAAAACAAT[AZG]ATCACCATGAAAAAAG rsl597005 AGTATCTGGAATCTAC[AZG]AGGATCTCAAACATAT rsl0103296 AGTATTTATTTGCCTC[AZG]CATTTATGTCACATGA rs4931086 AGTCAAATTGAGCACA[AZG]AGGAAGGCACGCATCT

rsl0795630 AGTCACTAAGGAAAAAIA/GITCAGAGATACTAGGAG rsll254934 AGTCCAATAGGTATAA[A/T]CTGTCTCTGGTTGTAC rs628118 AGTCCCAAAGGTTCAG[A/G]AACTGGGGCTGAAGAG rsl6962583 AGTCCCAGTGAAAGGA[CZT]AGGTGGAAATATTTCT rs321728 AGTCTGAAGAAGATAAIC/TIGTCATCATGGCTTAAT rsl3328187 AGTCTTTCAATCAATC[AZG]CCTTCCTTATCCATCC rs3807707 AGTGACTGAAGGAGCC[AZG]GAGTAGACTATACAAG rs2479967 AGTGGGATATTATTCA[AZG]TCGTGAGAAGGAATGA rs6500553 AGTGTGCACTTCAAAA[GZT]GACGTTTGGAGATGAA rs7049018 AGTGTTCTCTGCCAGG [AZG]ATATGATATGGTTTGG rs7212143 AGTTATTTTCTGGCCC[CZT]AAAAGTCTAACTCATG rsl7079910 AGTTCAGCTTGATGTA[GZT]AACAGGCCTCTGAAAG rs41368047 AGTTGTTATTAGCTAC[AZG]GAAAACATCACAAAAT rs8046997 AGTTTTCTTAGCCACA[CZG]TGGAGAAAGTTACGGA rsl2716329 ATAAAACCTTTGTACA[CZT]TGGGAAGAATTAGAAA rs487311 ATAAAAGGCCCTTCTC[AZG]ATAGCCACACAGCTAC rs6834683 ATAAACAAATCACTGG[AZG]AATGCTGCACAGGTAC rs9619167 ATAAAGCAGATGCTAA[CZT]GTTCTGTCCCTTTTAT rsll721335 ATAAATAGCACTGGGA[CZT]AAGTATCAACACCATT rs2797275 ATAACTATATGTTTCT[GZT]AAGTCTCTATTGACAG rsl395804 ATAATGAGTTCTGAAG[AZG]AGAGAGACAGGGATGA rs7595869 ATACATAAAATTGTTG[CZT]ACAAGGCATATGCTGA rslO18O221 ATACATATTGTTCCTA[CZG]AAGTATCCTTAGTGAA rs41518745 ATACTCTGTGGAAACA[AZG]ATGATTCAGGGCTCCT rsll243976 ATACTTACCCAAGCAA[CZT]AAGCAAAGTACCGAAT rsl672384 ATAGCATTTTCGTTAT[CZG]AGGGCTTTTGATAGAG rs9792571 ATAGCTCCGATTTCAA[CZG]AAAGGATGAGTCCAAT rs462312 ATAGGAATACAGCAAA[CZG]TAAAATGCCACAAAAG rsl517914 ATAGGCAGGAGGATAA[AZG]AAATTACTGCTTTGCT rs2555537 ATAGGCCATCACTTAC[CZT]ACACCAATGTCCACAG rs7198632 ATAGTGGTGACAAAGA[CZT]GTTTGATTCACAAAGA rsl6852600 ATATAACTGTCAAAAT[AZG]AGCAGTATAGATGGTA rsll75299 AGAATTGTTAGCACAG[AZC]AAGGAGAAGGAGTAGC rs396047 ATATAGCATGGTAGTC[AZG]AGAGGACAGGTAGCAC rs4528488 ATATCATGAAAGGAAA[CZT]ATAGCTGAGACATTTT rs6826407 ATATCCTGATGCCACA[CZT]TGGATAGAACAGCAGG rs4908511 ATATTCTTGTACTAAA[CZG]CATAGCTCAGGAACAT rs838022 ATATTTATTCGTGAAA[CZT]AGGTGATAAAGAAAAA rsl2109718 ATATTTGGTTTTGAAG[GZT]ACAAGAACTAGAAGAG rs4551590 ATCAAATATGTTTTCT[CZG]ACCAAAGGGATTTAGG rsl7478715 TGTGTGCGCACATTCA[CZG]AATGTTAGAAAAAAAC rsl7684525 ATCAAGATAATGTCAC[CZT]GAAGGCCTCTGGGAAA rsll705183 ATCAGAGTAATACCTG[CZT]CAATTATTGGAAAGTA rsl638021 ATCAGCGAACCTTTGA[AZG]CTTTGCCGCTGGTAGG rsl3335367 ATCATTTTTAAGTGTA[GZT]GTGTACCCAGTATCAA rs7848622 ATCCAGGCCTACAGAA[CZG]ATGATGAACTTAATTG

rsl6907853 ATCCATACTGCCAGAT[A/T]AAAGTAGTCCACATGG rsl7230563 ATCCCAGATGGGATTA[A/G]GCTTGCAATTGTTGCT rs2890763 ATCCTGATG GAAGTAC [A/G]CAATATTACCTGTG AA rs6564635 ATCCTTTTGTCACGTG[C/T]CACAATTTCAAGCTCC rs4588071 ATCTAACAAATTATCAIA/GJTAGCCATAAGCAAATC rsl517796 ATCTACAATCTAGTTC[A/G]CCAGCTTGCACTGAAT rsl0091954 ATCTAGCCAAGCTTAC[C/T]GATCCCATCCTTGAAG rsl7376559 ATCTGAAATGCCAGGA[A/G]ACTCTGCCAGCCAGGG rs986649 ATCTTACGGAAGTGCA[A/G]AATTATTCAGGGGTGT rs6129188 ATCTTAGTATGGTGGAIA/GITAAGAATTGAGACTGA rsll250877 ATGAAAGGGCAAAGAG[G/T]CCTCCGGTTTTCCACA rsl7055261 TAAATTCCTCTGTGAT[G/T]AGTCGTATTAI I I I I I rs6537880 ATGAAGAAAACTGTAA[G/T]TCACGTGCTCCATAGC rslO994143 ATGAAGGGAAGCACAA[AZG]TAAGTATAGCTTTGGA rs244104 ATGAATCTGAACTTTA[C/T]CCTGATGGCTCTGAAT rsl7216354 ATGAGATAAGAAAAAA[G/T]CATTAACTGCCTTGAC rsl806139 ATGATCAAAGATGGCT[C/T]ACTCTTTTAAGTCAAA rsl7051705 ATGATGACTGCAGGCA[C/G]AGAATAAAGCTGGTGA rs2285369 ATGATTCCCTGAAGAC[C/T]GCTTCTTAGAAATGAC rs2940531 ATG C AC AAAAC AATAG [A/G] AGG AAGCAATAATGTC rs746112 ATGCACTTACATGAAA[A/G]AATTTCCACATGTACT rsll077623 ATGCAGAAAGAGTAAA[CZG]ATAGCAGGTGTGAGAC rs9550627 ATGCCACTCCACTTAC[CZG]CATTCAACAATAAACT rsl647786 ATGCTAGCTCATCAAA[C/G]AGAATTAACTACAGTA rs362539 ATGCTCAAGTTTATTG[A/G]CAAAATGCCCACCAGA rsl891455 ATGGAGAGACACAGAG[A/C]AGCAAGAATTTCGCCA rs6010063 ATGGAGCGACGCAGAA[C/T]GAGCGCACCTTGAGGA rs4752150 ATGGCATAATAAGCAC[C/T]GCCTTTGCCTCACTGA rs6688451 ATGGCCCTTTCCTAGA[A/G]TCAGTGTCTTTAACTG rs2405747 ATGGCTGACCAAGTGC[C/T]GAGCAAATGAATGTGG rsll795219 ATGGGTAAAGTGCTTA[A/C]AGTGGTGCCTGACAAG rs2007291 ATGGGTGATGGCACCA[AZT]GTTGGAGAGATGACAG rs7852172 ATGGTCTCTGTCACTG[C/T] AGCTGTGG AGTAAGCC rs3783185 ATGTACACCAGATCTA[CZT]GGCTTGGAGACCAAAG rs7200438 ATGTAGAAGAGATGAA[AZT]TTCAAGCATGGGTTTC rs7898152 ATGTCCTCTGTACCTA[C/T]GTCCCTGCATTGCTTT rs2993561 ATGTCTCTGCAGATCA[A/G]TGAAGGTTGTATCCTT rs2201261 ATGTCTGCATATCTGA[C/T]GTATGGACTGCAGAAT rsl0069251 ATGTGGGTATACATGA[A/C]GTGTGTCACTTTCTAG rs9901001 ATGTGGTAAGTGTCAC[AZG]GCAAATAGGGGAACTC rs2337146 ATGTTGATGTTTTCCA[A/G]TACTTTTTTGGTCTCC rs687328 ATGTTGCTAGATGTGA[CZT]GGAAGATACAAAGAAG rsl0023765 ATTAAGAATTTGAACA[A/C]CTCCTAAACAGCCTGT rs7584087 ATTATAACAATGGCTA[C/G]AGGTTCTTTTTTTCCA rsl520835 ATTATATTTTGAGATAIA/CIGCATGATTTGAGGGTA rs2629646 ATTATCCCAGTTTTGC[A/C]GATAAAGAAGCTGGAG

rsl7159711 ATTATCTTGTTGAATC[GA]AAATGTGAATGAGTCA rs2317031 ATTATGCAGCCATAGA[A/G]AGTCAGAACACTGGCA rs4454352 ATTCAAACTTTGGAGA[A/G]GGCTATTTCAAATTAT rsll709077 ATTCACAGAATTATGA[C/T]CTTGCTTTTGAGGTGG rsl2611602 ATTCATTTCCAGAGAT[C/G]ACTAAAAATCAGAGAT rsl7138695 ATTGATTTGAAATGCAIA/GICTTTATTTGGATCTGT rsl2443360 ATTGGCCCACGTCCCT[A/G]AAGCTTGAAGAACTCG rsl931916 ACTGCTACCCCTAAAA[C/T]AGGAGAAACTGACAGG rsl6830596 ATTGGGTAAATCCCTA[C/T]GTGGGCACCGGAAATA rsl0881770 ATTGTCTCATGGGATC[AZG]ATCATGTGTATATGTA rsl7070295 ATTGTTTTAAAAGCCA[C/G]GGCAGTAACTTACATT rs2282873 ATTTAAGTGCCTGCTA[A/G]CTTTGCCACTATGTCT rs356073 ATTTAATATGGTTAGAlC/ηGGATTGATATTCTTTA rs4470917 ATTTACTATGCTTCAC[CZT]CAGTGCATCAGCTCTC rs2923297 ATTTAGCTCTTTTGAT[AZG]AGCCTTGCCAGAACTC rsl7065554 TCTCTCTGGGAGTGAA[AZT]CATTTTGCCAGCAACA rsl0932785 ATTTCATTTGATCACA[AZG]CATA I I I I IACAAATC rsllO54841 ATTTCTTGACGCAGAC[AZC]ATGTAATATAAAATGA rs3014960 ATTTCTTTATACAGCA[AZG]ATTGCACAGAGTTTGA rs6592369 ATTTGCTTATTCTACC[AZG]ATTTCTCAGTTCTAAC rsl7018796 ATTTTACTACCACTAC[CZG]ATCATTGTAAAGCAGA rsl7090733 ATTTTCTCCAGCCAAC[AZC]GTCGTGACACTGATTC rsl469335 ATTTTCTG AG AAGTGG [AZG]AAAAACAACAGAATCT rsl372851 ATTTTGTCATTGTCCC[AZG]CCTTGGGTCTTTTCCA rsl7065173 AI I I I I GCCAGTTCTA[AZC]AACAATACTTCCAAAG rs2260163 A I I I I I GGAGAATGAA[CZT]GCTAAACAGAAGAATG rsl0780343 CAAAAATCATCCTTAA[CZT]GTGCTTGGTGGGTTGC rs2453481 CAAAATCCCATGGACC[CZT]CTTACTGGTAGGCATG rsll242886 CAAAATTAACTTGCTA[CZG]ATCTTGACTGAGCCAG rs9958706 CAAACAACAGTTTATA[AZT]GACACAGAGTATCCCT rs7713732 CAAAGGCAGATTTCAA[AZC]AGTCTATAAAAACAAT rs9661906 CAAATGCTGGTAACTA[GZT]ATCTGTTTGCATTTTA rsl452875 CAAATGTAGCCACTTA[AZC]AACAACACACATTCAT rsl6990689 CAAATTGTGGAAAACA[CZT]CTCAATATTAAGCTTT rs573673 CAACAAGAGCTGTAAC[CZG]CTTTAAAGAGTTTGTG rs4877118 CAACAGCAATGACTTA[AZT]CATTTCTATGGTTTCT rsl7755242 CAACCAGTTCATAAGA[CZG]AGTAATCTAAGAGGAA rsl7348460 CAACTCAGCATGGAAA[GZT]CAGAATCCACCAGATG rsl3286682 CAACTGGTCTGACCAA[AZC]AAGAGAGAGATATGCT rs4797778 CAAGAAAGCTACTAGA[AZG]CAAATAGATGAATTCA rsl0923574 CAAGAAATACCTATTA[AZC]ATCCAGCAGAACTAAT rs9379479 CAAG AGTTAAG AAAGG [AZG]AATAATGGTAGCTGAA rs6785764 CAAGCC I I L I I I I CTA[AZG]GTAATAGCTGGAAGTC rsl7210543 CAAGTGTTATGTGCAT[CZT]ACTAAATCTGGGCGGG rs2241883 CAATAAACTGGTGACA[AZG]CTTTCAAAAACATCAA rs746655 CAATAACCTGAGGATA[AZG]GAATGCGGGCAGAGTT

rs2084275 CAATMGGTATCCCAT[A/G]AAACCATCTAUAAAC rs752822 CAATCTCAGATCCTTG[C/T]AAGACAGCCAAGATTC rsl71512 CAATGGAGAGCCATTG[A/C]AGGGGAGAAAGAAGCA rs7651990 CAATTCTGGACAGACG[A/G]CCTTTCCTGCATGAGT rsl6909596 CAATTTCAATGGTCTA[C/T]GTTAAAAACTCATCTT rsl0923875 CACAAAAGAATGTACC[C/T]GAGTCTGTTATAACCA rsl2502711 CACAACTAACTTTTGC[C/T]CAAAATACAGATGCAA rsl931047 GCTATTCATCAAAATAtA/GlGAAACATAGGAAGGAA rsll614019 CACACACACACACAGA[C/T]GATTGTGGACTCCTCT rs41353747 CACACAGGGCTGAGAA[C/T]TGTTGTATATTCTGCC rsl7548270 CACAGCTTAACTGCCA[A/G]AGAAAAGAACAAAGTC rs609017 CACAGGATTGACCTTC[A/G]CAATGATGTGTACCTG rsl2563273 CACATCAACTCTACGA[C/T]ATAATACCACAGGTCC rs2624870 CACATCGTCCCAGTTA[A/G]GTCATCTCAGCAATAA rsl7294592 CACATTAAAAAAATTAfC/T]GCAAAGATGTTCAACT rslll47694 CACATTCTATGTACTA[A/G]GCTTGGTGTTACGGAG rs3826785 CACCAAAGAATTCGGA[C/T]GGTACAGCCACAGGCA rsll934931 CACCACTTCCTTAAGC[A/G]GATCTCCCTGGCAACT rs629242 CACCCAGTGTTTGTTA[C/T]ATCATGCATAAGTACA rs6414157 CACCCCCTGCCAAAGA[C/T]GTTCATATTCTAATCC rs6582600 CACCGGAAAAACTACT[G/T]ACAACTGGCCACGAGA rsl854226 CAATTCTAACTTTATA[C/T]GCACCAGAGTGACCAA rsl31384 CACGGACCGTGGTAAC[C/T]GTGGCAGCAGGAAGAC rsll725743 CACGGGATGTGGCATA[A/G]GAGTGTCTAAAACTAG rsl0782535 CACGGTTGTCTGTAGG[A/G] AAACTCCTG AAGGGTT rs2675437 CACGTTTTCAGTTTCC[C/T]GCTACTCCCACAGCCC rs2796466 CACTACCCAGCAAACA[G/T]AAGAGGAAAGTAACTG rsl607265 CACTAGTGAGTCAATA[A/C]CCTTCAGAGTGCTCCA rsl7101464 CACTCTACATACTCTA[C/T]GGAATGGCCACTCTTC rs9814244 CACTGCAGGAAGTCAG[C/T]CCTTTGCATTTCTAAC rs7103136 CACTGTGGCCAATTCA[C/T]GCTACCAATGTGACAT rs6672191 CACTTTCTGATTAACC[C/T]GGAAATTTAGTTAGCC rsl6856558 CAGAAAAACTATAGAA[A/G]TGCAACACAATAGAAC rsl7031401 CAGAAGACACTTGAGC[A/G]ATGAGATGTTCCCTGT rsl450053 CAGACTTAAATGCACC[A/G]CACATTGGATGATTCG rs41362049 CAGACTTTCACATCCA[A/G]ATTCAGGCCCATAGCT rs7112864 CAGAGAATCCATAAGA[A/G]ACTGAGAATTCTGAGT rsl6906210 CAGAGCTCATTTGCAC[A/G]GTCATAAGGTTTTCAT rs7943587 CAGAGGCTCCTCCTCA[G/T]CTTGGTCATCTGTGGC rs2881639 CAGAGGGAAGTGTTACtA/GjAAGGGGTCAGTAGTTT rs2173712 CAGAGTGAGTGCAGAC[A/G]AGTGACTGTCGTCCTC rslO5O8133 TACCTCATAGTGTTAA[A/G]AGTTAATGCACTGATG rsl7122027 CAGCACTTTATGTGCC[C/T]CTTGGTTTCAGGATGC rs2223537 CAGCAGAATCATGAAC[C/G]GAATAAACCTTTTTTC rsll228612 CAGCAGCAGCAGGAAC[C/G]GGACTAAGGACTCCAC rsll060447 CAGCATTTGCCAGTAA[C/T]GTTGTCCGTGCATTGC

rs3110374 CAGCCTTATATTGGAA[C/G]ATGATGCTGTCCAGGA rs7199486 CAGCGAGGGAGATAAG[C/G]CTATTTTGGCCAAGGA rsl7062449 CAGCTACTAACTTTCC[A/C]AAATCAAGGAGTCAGA rsl6907854 CAGCTATTCATTGAGA[C/T]TATAGCCATTTCCATC rsl2098617 CAGCTCAGGTTCAGCA[A/G]AGGAATGACAGTATCA rs4672097 CAGCTTTACGGCAATG [A/G] AAAACAATTTTATAAA rs886125 CAGGAAGTTTGGTCAA[C/T]AGTAATGCATCAATAT rs7328649 TACCAAGTCACTATTA[C/T]AGAGCCAATCCAGATG rsl344432 CAGGG ACTTAAGGCAG[A/T] AGTGG AAAAACTAG AC rs6733830 CAGGG AGGCTG ACTAG [C/T]ACTTAGTGG ACTGGAT rs9925226 CAGGTπCTCAGAACC[A/G]CAAGCTCATAAGTAAG rsl455993 CAGTAATCCAG GATAA [A/T]GTCCCATCTG CCTATT rsl7451397 CAGTCAAGATGAGATC[A/G]ACAAATTTAACATCTT rs729734 CAGTCCAATGACAGGA[A/G]GCAGCAAAAAGTAGTT rs4556722 CAGTCCATGACTCCAT[G/T]AGTGTCCACGCCTCTC rs2151176 CAGTGGAGTGTAGCTA[C/T]GAGGGTTGGCTTTGTG rs4638587 CAGTGGCAGATTGCCC[A/G]GGAAGAATTGGAGGCA rsl7760600 CAGTGTTAAATCTACA[C/T]GGCACTGGAATCTGGA rs862989 CAGTTGTGACTAATAA[C/T]CCTAAAACTAAAATGG rsl7005004 CATAAAACTGAAAAAqA/GJGCAGGTATATGAAAGG rs2224925 CATAAAC AG ATCC AAC [C/T] G CAAAAACC ATATG AT rsll983076 CATAATTACTCAAAGT[G/T]AAGTCGTGATCCATTA rs3130955 CATACTGATCTTGAAG[G/T]CTAGTGTAGCAGATAC rsl2875217 CATAGGTGGTGATTCAtG/ηTAGTTAGACAAATAGA rsl345364 CATATCAATCACATTA[C/T]ACATTTTGGAATCACA rs2819956 CATATCCATCATTGTG [C/G] AAAGTTCTACTGGACA rs2734454 CATATGCCTGAACTTAtC/T]CTAAAAAATTTCCTAC rslll24232 CATCCAGGGAACCACAIC/TJGCCTAGAAAGACCCCA rsl341992 CATGCCTGTTTTCACA[C/T]AGAGTAAGGTGCAAGA rs6968469 CATGCTAACTTTGGAC[A/T]GAATCCATTTGAAAGT rs84996 CATGGGCCTTGGAAAC[C/T]GAGTGATCATGGTGAC rsl494676 CATGTCAGTTGTTATA[C/T]GCCCACTGTTTTTATT rsl7017493 CATGTGCACAAGACCAfC/GJGAGAGTAACTGATCCT rs2359536 CATTACCTCTACCCCA[A/G]TATTTCACTGTTGAGT rs6691988 CATTAGTTAGGCATCA[A/G]AGCCTCAAAATGAATA rs4744301 CATTATCCAGTTTTAA[C/T]AGAACCAACGTGACCC rsl834520 CATTCCTTGGCAAACT[A/G]ACAGAATGAAATCTCA rsl2005932 CATTGTTTTAAGATAAlC/TlTCCAGAATCTTCACGG rs4887475 CATTTTGGCTTGATCA[A/T]CTCATCAGGGGAATTC rs6592636 CATTTTTAGATGATAA[C/T]GTCTCTACTCCAGATA rsl6949946 CCAAAATAAAGCAAGA[A/C]CTTCAAAGATGTTTCA rs7740342 CCAAATGGGCTAGAAC[A/G]CGGACGATCTGAACTG rs292692 CCAACTAAGAAACGTA[C/T]GAGTGCTTGCCTCTGC rs838865 CCAAGATGCTCTGAAA[C/T]TGGAACTTTCTCTCTG rs876023 CCAAGCTGAGGGAAGAfC/TlGATTAACGCTAGCCTC rs8062421 CCAAGTGGGCTTAACA[C/T]GGACACTGCCCTGGGG

rs6966840 CCAAGTTTCCATGAAC[A/G]GATAAACAGATCAACA rs8103441 CCAA I I I C I I IAGTAA[C/G]AGTCAGCAAAAGCCTT rs7738979 CCACAAAGTTGTTTTC[G/T]ACGAGAATTCGATGGG rs7135161 CCACAGTCATGCTCAA[C/T]CAAATATTTTATTTTG rs2767770 CCAGAATATATACAAC[A/C]CAAAAGATTGCAGTGG rs6825063 CCAGCTCACTAGAACA[A/G]CGTGTACAAGGATTGG rsl7025744 CCAGTGCTTGACCCTC[A/G]CCAACGACCGCACTCT rsl0945783 CCAGTGTCTCTTAAAA[C/T]TGACATAAAACATAAA rsl060582 CCAGTTGTTTGAAAGC[A/G]CAGCCGTGACCTGGCC rsl7093060 CCATCTTATACAATCA[C/T]CTTTGCAGGTTGGATG rsl2459087 CCATGAAACGGTCGGC[A/G]ATGATGGACACTCCCA rs7988937 CCATGGAAACCACCGA[A/G]GTCAATCTCAATTATA rsl053495 CCATGGGGAGAAATGA[C/T]GGTGTGGGCCAAATCA rs6906897 CCATTCCTCCTTGACA[C/T]TGGATATGCATTCTTT rs6861925 CCATTGTCTGAAGGAA[C/G]AGAAATTACTGATGAA rs7606259 CCATTTGCCCATCCCA[A/G]ACAGAGGTAGCCTCCT rs8019624 TAAATAAACTCGAGAAtA/ηGATAAATGTCAAGGAC rs4726612 CCCAAAGCTGTGTCCA[A/G]TCACGTTCCTGTGTGT rs6124066 CCCACAAACTGAGAGA[A/G]ATGTGTAGAAACAGGC rs4500554 CCCACACTACTGGTAC[A/C]AATTTTGTGAATTGGT rsl7645582 CCCACAGCTCTGTGAA[A/G]TGGCAGGTCATCCATT rsl2135117 CCCACATTTGCACTTA[A/T]AGTTGGCTCTTCTCAG rs2194397 CCCACCAGCACAGTGA[C/T]GGTTTATAAATGCCAT rsl215610 CCCACCTCG AAGATG A[C/G] AAGTTTG AACCACATG rsll958260 CCCACCTGGCTAGTAA[C/T]GGCAAATGCCTACTTA rs6465748 CCCAGCAATCAGTTCA[A/G]TCATTGGAAGCTCCCA rs9662546 CCCAGTGGAGCAAACA[C/T]CTGGGTTCCTAAGTCA rsl2465985 CCCCACACAGGACAGA[A/G]CCTGGAATCACTTTCT rsll632275 CCCCTTGAAAGTAGAA[A/G]AGGAAGACAGAAGCAT rslO21484 TCACCTCTAGATAAAA[C/G]TATTTAATTGCCGCTA rsl7724855 CCCTAATCCTGTGGCA[A/G]AGGTCACTCAAACCCT rsl871598 CCCTACTCAGAATAGC[A/G]AGTCCTGCAGCCCTGG rs836104 CCCTGGATCTTATTGA[A/C]GCCTTCTGTTTTAGCT rs2412878 CCCTTTTAAAGTCCTG[A/G]ATAAACACCTGCTGGT rs4698255 CCGAAGTGTTCACCTA[A/G]AATAGTACAGTGCACC rs8004785 CCG AATAATTACTG AG [A/G] AAG ACTGAGATATTCA rs9323124 GGTGGGAATAGCTTCA[A/T]GCCAGGAAATAGCTTT rs752819 CAGACCCAGTGCTAGA[C/T]GTAGATCCCAATCACA rsl7067292 CCTACTAAACTCTACC[A/G]CATGGAGTCATACCTC rsl0898297 CCTATCTATCAATCCA[A/T]GCTAAATCCAGGTCAT rsl6857430 CCTCAGTGGTCAAGTC[C/T]AGTCTGGTTGTGGAGG rs2159168 CCTCCCAGAGTGATAG[G/T]ATTACATGCGTGAGCC rs4433564 CCTCCCCTTCCTTTAA[C/T]GAACTGAGTGACTTTC rs881754 CCTCTAC I I I I I ATTC[A/G]CATCGAATTGCAGACC rs22O739 CCTCTGTCAGCACTAC[A/G]ACCACCACTCATTCTG rsl2118092 CCTGATGACTGTTTTA[C/T]GATGCGCTACCTTGTT

rsl3093318 CCTGCAAGTAAATTCC[A/G]GGAAAATACTATAGTA rsll213005 CCTGCCAGGAGTAACC[A/G]AGGAAGCCAACCCTGA rs4908527 CCTGGAGTCCACTGCA[A/G]GCACAAGCAGGCAAAG rsl0017198 CCTGTAGGATCCTGAA[C/T]CACAACCATTACAATT rsll200820 CCTGTCTAACCCTCAT[A/G]AGAAAGATCCTGGTTG rs7245562 CCTGTGTTTTCCTATG[A/G] AGGTGG AACGTGTTTA rs9648818 CCTTATTGG AG AATGG [A/T] ATCTAG AAGCCAAGGT rsl7093200 GATGTTTGTTGGAGGA[C/G]AGTAATATCTCAGTTC rs2382642 CCTTGATCTCGGGTTG[G/T]ATGTTCCCCGTGTCCC rsl327786 CCTTTCCCTTTCTCAC[A/G]CTAAATGTCCTGAATA rsl850828 CCTTTGTGCTGTCCCA[A/C]AGATTTGTTTGAGGAC rs710010 AGAGAAAGATGTCAAA[A/C]GTGAAAGCAAAGTTCT rs2268552 CGAGATTTCAGAAAAC[A/G]GTTTCCTCTTCTTCAA rsl7098286 GTCAGAAAAGGATCCA[C/G]GGAGATATAATTGCAG rs7573323 CGATGGTACATGAAGA[C/T]GCAAAGGGAAATATTT rs32053 CGCACTGTGCAGTAAC[C/T]ATATATCTCCTCCTCT rs7083300 CGGGCAGGACTGCCCA[A/G]TGCTTTCCTGGCTTAG rsl7165198 CGGGGTGAGGTGGAAA[C/T]GTAGGTGTGCCATTCT rs893980 CGTAAATGCTCCCTAC[A/T]ATACCCCTAGTAAGTA rs7640305 CGTGCCA I I I I I I AAC[A/C] ATCACTAGTCTCATTG rs2139109 CGTGCTCTGTTATCCC[A/G]GAAAGCTTGCAATAGC rsl212352 CGTGGCAAATTGTTTA[A/T]CGTGTCATGTAATTTA rsl7699211 CGTGGCTCGAGGTTAC[C/T]GGTACTTTGTGTACTT rs6016546 CGTTTTGTCTAATGCA[A/G]TCAAGACTAGTGGTTC rsl207692 CTAAATCCTTCCGTAA[C/T]GTGTGGTCAAGGAGTT rslO441747 CTAAATCTGTATACAT[C/G]AGGCAAAAAGCAAAGC rsl2713315 CTAACAGTGTCCCTTA[C/T]AGAAATCAGTGAAACA rsl2086219 CTAAGAAGGCAGAGAA[C/T]AACCAGAAAGCGAATG rs8038773 CTAAGATACAGCTCTC[A/G]CAATATTTGGAAGGCC rsl2489725 CTAATCTACAAAGTAA[C/T]GGTCTTCAGGCTTTGA rsl0756762 CTAATTTGCAAATCCA[A/G]TGATATGGTCAAATGA rsllO59335 CTACAAAATCAGACAAIA/GICCAGTTTATTAATTTG rs6442490 CTACCTCAGTTAGTTA[G/T]ACTGGTTTTCCTCCTC rslll89420 CTACCTTGTGAGATGA[A/G]CAATATTATCCCCATG rslO483818 CTTATTTGTATATCCA[C/T]GGCTAGGTCTAAAGAG rs34530749 CTACTGCTTGCATTAA[A/G]CACAACAL I I C I I I CC rsl7379759 CTACTGTGAAAAAGAA[C/T]GAAAGTCAACGTGGAG rsl2320124 CTAGAAGATTTAGTAT[A/C]AGGAACAAACAGACAA rs7727099 CTAGACTTTTCTGCCA[C/T]GTAAACTAAGACTGAT rsl7348373 CTAGTTCAGCGCTTTA[C/T]CTAATTCTTAAATGAG rs2303791 CTCAAAGCAGGACCAA[G/T]AAATATGACATGCCTC rsl0133885 CTCAAGCAACAACTGA[C/T]GCCCTGTGTCCAACTA rs7793301 CTCAAGTGTTGCTTTA[C/T]CCTTGGAGGCACTGGG rs2956560 CTCACCTCTAACAATA[C/T]GCTGGAAAAAAAATTA rsl2148258 CTCAGCTTCAAAAGAC[A/G]GAGACTCTTGGGCGTT rs2983713 CTCATCCATATTTAAC[A/T]ACATCGTCCTTCAACT

rsllO83275 CTCATTGTGTCTGTAG[A/ηAAAAGATACACCTTGG rsll775193 CTCCAAATAGCTCCCA[A/G]TGAGCCTTACCTCCTG rs903935 CTCCAAGTCCTCAACC[A/C]GGGAAATCGCCCTTCT rslO451228 CTCCACCATCAAAATC[A/G]AGGACTGTGGATATTT rsl6880316 CTCCACTAGTCTCATC[A/G]ACAATATTATTTAGTT rsll634311 CTCCACTCCAGAGGAA[C/T]GGGTCAGGCGGTGCAC rs9287588 CTCCATACTCTTTCAA[A/T]GGACGATATCAGCTGT rs9633725 CTCCATTTCACCCAAG[A/T]AAAAGTCGGTATGTGC rs619865 CTCCCAAACACTAGGC[A/G]AAAGGATCTGCCTCGG rs2362852 CTCCTGCTTCTTTTCT[C/T]AACACAGTAGCCAGGG rsl7337267 CTCCTTTGCATCAGCC[A/G]CCGTAATAAGTAGTCC rsl7421624 CTCTACCTCTCTGATA[C/T]CATTTATTTACCCTGC rs7512708 CTCTCCGCATTCCCCC[C/G]AGTTTCTCCCCTCCCT rsl2463429 CTCTGAGCTCTTCAAA[A/C]TGAACCATAAGCTGGG rsll839787 CTCTGGGGTAAATGCC[C/T]AAAAGTGTCGTAATTG rsl7104103 CTCTTCCTTTTTGAAC[A/G]AAGTTGAGGTTAGCTG rsl2592796 CTCTTGACATTACCTA[G/T]CAATTGACATTTGGTT rs6868068 CTCTTTTAGTTGCATA[C/T]AAGTGAATCATAATCC rs6669656 CTCTTTTCTTTGTGCC[A/G]CCATGTGTCGTCATAC rs468781 CTGAAACAACTTCCAC[A/G]CACAGTGTATGATTTC rsl6981525 CTGAAGCATCTCCAAA[A/G]GTCACACAAAAGGAGA rs7504269 CTGAAGTCCACGTTCT[C/T]ACTCCAACATTACTAA rs7081330 CTGAAGTCTTTTCAGA[A/G]CCTTTGCCAGCACTTT rs7795796 CTGAATCATAGATCAC[A/G]GGAAGAATATTGCACT rsl425522 CTGACAATCCAAGAAA[C/T]GAATCTTTAGCATTGG rs6687221 CTGACACTTGCTCTAC[A/G]ACAAAGGAGTTACTAA rs4320728 CTGACCTGACACAAAA[C/T]TCGTACTCCTTCCCCG rs6561621 CTGAGAATCGGGTAAqA/GIGAGAGGTTTATTGATT rs41493449 CTGAGAGGTGTTCAGA[C/T]GGTGAGTTAGGAACAA rs2131039 CTGAGCTTTCAACATC[A/G]GACATTCAGGTGGCTT rs4940732 CTGATAGAGAGCCTTA[C/T]GGATTGGGTTGACACT rs2043624 CTGATCATTGGTTCAA[A/C]TGTTCAGCCAGGCCAA rsl0889262 CTGCAACATTGCCAAC[C/T]GATTGGACCCTGATTC rsl0484093 TAGTGGCTTAACTTAA[A/C]GTACAACAGTAATGGT rsl3280012 CTGCAGCAGTACTCTG[A/G]ATTTATGTGGGCTTTC rs9936215 CTGCCATCAGGACACG[A/G]AI I I I I I GGCCAGAAG rs4794029 CTGCCTAGAAGACATC[A/G]CATGAATCCATAGATG rsl440530 CTGCCTCTCTTGTAGC[C/T]GCCTTCTAGCAAAGCA rsl508486 CTGCCTGTGTAGAACA[A/G]ACTTTAGCTGACAAAA rsl7150725 CTGGAATCTGTGAGAA[C/G]TGGATCCTCTTGTAGA rs7002284 CTGGCTCCCTGATCCA[C/T]GGAGGAAGGCCTATTA rsl345978 CTGGCTCTTAGTGGAA[A/T]GGTGCTTTAAAAGTCC rsl2459634 CTGGGCTTAACACCCA[A/G]TAAAGAACTTTGCTGA rs684623 CTGGGTCTCAGGTATA[C/T]GAAATTCACAAGTACC rs2268518 CTGGTCCCATTTACTA[C/T]GTCAATTTCACAGATT rs34210830 CTGGTCCTAGTTACCC[C/G]ACAATATTGCTGCCTC

rsl2025910 CTGGTTCAACTGTACT[C/T]AGCCAGAGTTCTGAAG rsl565468 CTGTAACAAAAATTCC[C/T]CAATCTGCTTCATGGG rs9287619 CTGTAACGTTTGCATG[A/G]AATCCCATTACTGGGA rs6695554 CTGTATCCATATAAAG [A/C] AGCTGACTTAATTGAT rsl2410939 CTGTCAAGTACAAAACIA/GJAAACTGCAGAATAAAA rsl250270 CTGTGATAAAAGATTC[A/G]CTGTGACAGAGAACAA rs7163430 CTGTGGCCACTTCTGA[A/G]GTACGCTCCACACTTC rslll55133 CTGTGGCCL I I I I I I C[C/T]AAACACAGGAAGACAA rs708628 CTGTGGTGAGTGTCAC[A/G]CATCATTTCACACCGC rsl7287176 CTGTGTCTGACATCCA[A/G]ATATTTCTAGTACTGA rsl6914169 CTGTTAACAGTTAATTIC/TlAAGCCTGCAAATATCA rsl0740455 CTGTTTAATAAGCTGA[A/T]ATAGCTGTACCTAAAA rs532267 CTTAAAATATAAAAGA[C/T]GTCTACCAATCAATTA rs806861 CTTAAGTTGTGAGGCA[C/T]TCGGTACATAGATTGA rs2279246 CTTAATTTGGTAGCCA[C/T]GTTGCAAGGAAGAAGT rs6942409 CTTACAGGCAACAAAC[A/C]AGTGCTGGAACGTGGC rs7179124 CTTACATATGTTAGCT[C/G]AAATTTTCAAAATACC rs7952757 CTTACCTGGGGCGCCA[A/G]ATTGACATTC I I I I I I rsllll7913 CTTACTGAAATAAGAAIA/GJTATGGATGTAGGACTG rsl0475286 CTTATTACTCAGTGGG [A/G] AAG ACAACATTG AACA rsl3131633 CTTATTTTATGAGGGAIA/GIATTTTGGAGTTAAAGA rsl2120384 CTTCATACCTTAACGA[A/T]AGAAAATAACCAGCTT rsl7118699 CTTCATGAGTTGTTTC[A/G]AGGACTAAACCAGAAG rs6432398 CTTCCCATTTCTTGCA[A/G]GGTTAAGTCCAAAAAC rs4540877 CTTCCTACCTTCTTGA[C/G]CTGTCTTGGACTGCCC rs6509083 CTTCTTTGCTATATTAIG/TJGCTATTTGTGACAAAA rsl3169296 CTTGAGGTGTCTCTTA[A/C]CACATGGTTCTACGTG rs6893883 CTTG ATGATGTCACTG [A/G] ACCAACAAATCACCTT rs9547547 CTTGCAAGCTG AGTAG [C/G] CAAAACTTG CTTTG AG rs771149 CTTGCAGAGGGGCAGA[C/T]CGAGGTTCAATCATGT rs681515 CTTGCGTTGGTTTACC[C/T]AGACTCACAGGAGGCC rsl2577018 CTTGG AATTTATGTTG [A/G] AAACAG CTCCCTG ACC rs26047 CTTGGGAAACAAGAAC[A/G]AGGATGGAGTTCCAAG rsl565235 CTTGTGTCCAAACAAG[C/G]CTGTTTACAAAAGTGA rsl403795 CTTTAATCTGTCACTA[A/T]ATCTmTGCTTCTAT rs728486 CTTTAGGGTATG AATG [C/T] AACTTTGCTGTATG AC rsl0445407 CTTTCAG CCCAAGTTG [A/C] ATTAG G CC ATCTCACT rs904537 CTTTCATGTTGCAAAC[A/G]AAGAGCAAAAGCTGAG rs7308337 CTTTCCATTTACCTCA[C/T]GAGAGCAAAAGGTGCA rs4135079 CTTTCCTCTCCAAATA[C/G]TAAAGCAAACTTTTCC rsl765263 CTTTCTCTCTCTCAAC[G/T]GGTAATAGTTTGTAAC rs6861592 CTTTGATAAACGGAGAlG/TlTCCAAGAAGTCTTTAG rsl7099282 CTTTGCAGACATTGGA[A/G]ATAACATTTGAATGGG rs9868594 CTTTGGGATTTTTATA[C/T]GGCATAGTTAGACTGG rsl2380632 CTTTGGGGTTTCTCCA[A/G]TCATCTAAACTTCTGA rsl6835832 CTTTTAAAAATCATGA[C/G]AGTCCAGGGATCTAGA

rs7976001 CTTTTATGATAGACTA[A/G]AAGGTGAAGGG6AAGA rsllO16479 CTTTTGTTGTTGAGCA[A/T]CTTCCTGGCATTGGCC rslO981136 CTTTTTCAGAAATTAA[C/T]AAGCTGACCATGAAAT rs6780464 L I I I I I C I I GTCCTAC[C/T]GCATTGGCTAACACCT rs4732686 L I I I I I I L I I ATTAAG [C/T]CTG AATCTG AG ACAAG rs4845743 GAAAAAAGCCTACAGAIA/GITAATGATGTAAAGAAA rs4908660 GAAAACAAAAGGCGCAIC/TJTGAACATACAACCCCA rs6503264 GAAAATCCACATCTTA[C/T]ACTGTACACAAAAATC rs3131631 GAAAATTGCTCATCAA[C/G]TCGGGGAAGTCAAAGT rsl608962 ATTCATGAAAAGCTGAlA/GlATGTTATGGAGTATCA rsll240493 GAAACCCAGACCACCA[A/G]CTTGAGAGGACAAGGA rsl2209001 GAAATGTAAAGAAAGA[C/G]ATTGATCACTACCATA rslOO2825 GAAATTC I I C I I GCCA[C/T]GATTAACTTTCATTTC rs4513285 GAACAAGACTGACTAC[C/T]AACAAGCACAAGGAAA rs6842825 GAACAAGAGTGTGAGC[A/G]ACTGAATCTGCATTTT rs6986887 GAACAAGCTAGACTCA[A/G]TAGCAAGGCTTTTGTT rsl7610832 GAACAGACAGGAAGAA[A/G]GCGGGGTGAGGCTGTA rs6430799 GAACATTTCCTGATAC[C/T]AGTGCAACAGGTGACA rsl7069203 GAACCAGGGAAAGAAAIA/GITGTTGTTTGTTGTGAA rs272827 GAACTAATGAGTTTAA[C/T]GTGTTTAGCTGTGCCT rsl7178218 GAACTCCACCAAAAGAIC/TJCCCCGGCAAGAGATGA rs4649097 GAACTCCTGAATAACC[A/G]AAGAGAAGATCCTTCT rs6914589 GAACTGAACGGCGCAG[A/G]CTATTGACATATTTTT rs4436756 GAACTTACACATTTGA[C/T]CACACATTGGACCACC rsl938526 GAAGATGGCCATGACAIA/GJTGAGATTAAGAGACAC rsl7095017 GAAGATTCACTCCTGA[A/C]AAATAACTCAGTTGAC rs394738 G AAGCCTATAG ACTCG [A/G] AGTGCATAAAATACCC rs7378721 GAAGGGGCTGCGGAGC[A/G]AGAGAAAAGCGTCAGC rsl7035361 GAAGGTTπCAATCAA[C/G]GCAACTTTACGATCAG rs2339310 TAAATGTGTTATCTGA[A/G]CAAGCAAAACCTAAGA rs978363 GAATCAGACAGCAAAAtG/TJAATGTGTGGACAAGAT rsl2114519 GAATCATTGGATCTAGIA/GIACTTTGCATTCAGCAA rs4954634 GAATCCAGGTGGCAGG[C/T]AATACTCAGCAGACTG rs244099 GAATGCTTCCCTTCCA[A/T]GACAATATTCAGAGGC rs7098998 GACACTTTATCCAGCA[A/G]C I I I L I I AGAATAATG rsl2341793 GACAGAAAACACCGTC[C/T]CAAGCTTTGCAAATCT rs9366395 GACAGACTGTGAGGTA[C/T]ACAAATGTTAGTTTTA rs2402987 GACAGGTCACCGCATC[C/T]GAGGCAACGGAGACAA rs902425 GACATAAACCATCCCAIC/TJAAAAAGAGAGCAAGAG rsl2343115 G ACATTTATCTCTTCAIA/GJTACGACGTTTATAAAT rs6696001 GACCAGGCTAACAAAC[C/T]CTGAACCCACTGATGT rs630055 GACCTACTGCATCTTA[G/T]AGACTCACCACCAGGG rs7157285 GACCTGATACAACAAT[A/T]AAGAACATAAAGGCAT rs7551829 GACTGAAGCGTGAAGAIA/GJCAATACTCAGGACCTC rs2278866 GACTGGCGAAGTAAGA[C/T]AAGGCCATTTAGAGTT rsl6824518 GACTGTTTCAAAGGGC[A/C]GAAAGCTGTGGCCATG

rsl3215804 GACTTCAGTTATATCC[CZT]GGAACTGGCAAATTGT rs7231776 GAGAACAGAAGCTTCA[A/G]GAGAAGAAAATGGCCC rs9393424 GAGAAGGAATTGGCAC[AZT]CTAGAATTAATATTAT rsl7127785 GAGAATGAACTGATCA[C/T]AGAGACTTGAGGTAπ rs2901585 GAGACTCAAAGTTTCA[AZG]GAGCAAATAGAGAAGA rs4241505 GAGAGAATTAAATCTG[C/G]AAGCTAAGTGCCTTGG rsl7631686 GAGAGAGCAGAATAAG[AZG]CCCAGTGAATACATAG rs2518713 GAGAGGAAATACGTAA[C/T]TCTATGTCTATGCTTG rs6105236 GAGAGTCCATGTCATC[A/G]CTTTCCAAGACATCAG rs9857825 GAGAGTTTGGTGCATA[AZG]TAGACTCAAATAAAAT rs4976961 GAGCATCCCTTTCAAA[C/T]GGAAGGGCCGGATCCT rs9716 GAGCCCAAACATTAGA[C/T]CCCCTTGAGCACATGG rs921978 GAGCCTATAAGCCAGG [C/T] ATTCTGCTAGATGATA rsl615979 GAGCTAAGCACTTTAC[C/G]ACCTCTTCTTATCATC rs815860 GAGCTAGAAGTTCAAA[C/T]CATAAACAATAAGTGA rsll586497 GAGGACCACGAGGCCT[A/G]AGAGAACTTAAGTATC rs7530236 GAGGAGAGGAGTTTCA[C/T]GCAAAATAGCCCCCGC rsl3384003 GAGGATTTGCTATTGA[C/T]ACTGAACTGGATTAAC rsl7242790 GAGGCAGTAG ATAGTG [A/GlAAAGAGCACAGGGTGT rsl84577 GAGGCTGAATACTAGC[A/G]CTTATTCCGTCTAACT rsl737896 GAGGGTGACTAGCTCT[AZG]ACCTTGGAAAACCTTA rs2573700 GAGGTGGTATCGCCCA[CZT]GCAACATCTGGGACCC rsl2708308 GAGTAAAAGAGGAAGC[AZG]AAAGAAAGAAGGAAGA rsl7231034 GAGTCAAATTACTGTG[A/T]ACCTCCTCATGCCAGG rs9570866 GAGTCATTTGCATACA[C/T]TGTAAGGATAATAACC rsl3439727 GAGTCCAGGGCTGTTC[AZG]GAAAAATGAAGCAGTT rs4643744 GAGTCTGTTAGCCTAC[GZT]ATATCTACAGCTGAAG rs7753048 GAGTTAACCACTTGTA[C/T]TAAGGTCCAAACAGAA rs9684084 GAGTTGAAGTGTTCTA[C/T]AGGCCCATCCTTCCTA rs4746965 GAGTTGCCTGTTCTTC[A/G]AGTGGGCATACTGCCT rsl7756423 GAGTTTGCTTCCCAAAIC/GIAGTACATAGGCTACAA rsl7253697 GATAAAAATCTAGACC[AZG]CGTGTATCTTGTAACA rsl7255787 GATAAAAGCTAGGACAIA/GITGTAGGAAACTTTTTA rslO8O3226 GATAGTAATAAGGTGC[AZG]GAAGTAACCCAGTCTG rs41366350 GATATGAAACACAAAA[AZC]ACTGCCAGGAATATAG rsl453194 GATCACAGAAGGTTAA[AZC]TAATTCACAAACAAGA rsl3440446 GATCATACCTGCCTGA[CZT]TATACAAAAGGGTAGA rsl7031211 GATCA I I I I I I AGGAA[CZT]TAAGGCTCATGGGCGA rs360816 GATCCCAGAACAAACC[AZG]GCAATGTTGACACCCT rs41435745 GATCTGTCAACTTAAA[CZG]GTAAAAGGAACAGTGG rsl6867681 GATGAATCAGGCCAAA[CZT]CAGGATTCTGCTCTCA rs408705 GATGACTGCAGGATCT[AZG]AAAAAACCACGGTATG rsl0875746 GATGCACAGAGTTATA[AZC]AATGAAGAAGAGCTTT rsl461512 GATGGAAGCAGTATAC[CZT]ATTCTCACTTGTTTTA rsl6889229 GATGGAGTGTTTGCCA[CZT]AAGCTTCTCTTTATTC rsl6975740 GATGGCATGGCAGAGC[CZT]GACCCTAGCAACCCAG

rslO518984 TTAGAATAAGTACCAA[C/T]TGGAGCATCTAGCATC rsll750156 GATGGTTACACTAAAA[G/T]CTGATCTCACCACTAG rslO128886 GATGTAI I I I I CTTGC[A/G]CCTTTGTCCCAGCCAT rs2300999 GATGTGTCATTAGAAA[G/T]TCAGCTGGTTTTCTCA rs6559671 GATGTTAAAATTAAAAIC/TlGTGTACTGTCTTGTTT rs41326046 GATGTTAGGGGTGCTA[C/T]AGTACCTGAGGATGGA rs9914334 GATTAATATCTTATCC[C/G]ATCTGTAAGTGCTGTT rs9646767 GATTCACAGAAGAGAC[A/G]ACAAGTGAATTGGATC rs9935025 GATTCTGGGTCCTTCA[C/T]AGGTAGGTTAATGTGG rslO519O85 TGAAAACTGCCTTATqA/GlATGTAAGTGGTTGGGT rs4418381 GATTTCTGAGGTTGCT[C/T]AAGAGAAGACTCAGCA rs2052013 GATTTGGAACATAGAC[A/G]CTCTTACATTTGTTAG rsl0045757 GCAAATGAGTAAAGAC[C/T]GCTATACACATCCTAT rsl7108402 GCAACAAGGACAGTCA[C/T]AGTTTGCTAAACAAAA rs999994 GCAACCTCTGACATCA[C/T]GGCTAACATTAATCCA rsll223298 GCAACTGAAAAAATCA[C/T]GGTTTCAGACTTTGCA rsl0100443 GCAAGGCTTG ATCTTG [C/TlAGCACAAAATGTTTG A rs8012632 GCAATATTCCTCTTCC[A/G]AAGCTTGATTAACAAA rs989547 TGAAAGCAGCAGAAAC[C/T]GACTGGGGCTATAACT rsll958071 GCAATTGTTTTTGACA[C/T]TGGACATGATATAATA rs676382 GCACACCTACGCCATA[C/T]GGTATGCTTGAGAGCC rs3768256 CTTTGAAAGACTGACA[C/G]AGTAAAGAAGGCAGAT rsl0879974 G CACAGTCCTAATACA[C/T] CATATATG CTTG G GTG rsl6948985 GCACCCTCTGAAATAA[C/T]TCTGCAAACCACTGGG rsll722846 GCACTGCGCATAGCCA[A/G]ATCCATAGGTCTTAAT rs2846607 GCAGAATTTCCTGTCA[A/G]TCTATCCTAGGATGGT rs2171800 GCAGACTGGACGAAAC[A/G]ATCACTCCTATTTGTA rs9898731 GCAGCAAGGCCAGATC[A/G]ATACGATGAAAAACAA rsl7145664 GCAGCTCCTGAAACGA[A/G]ACAGTGTTCAGCCTGT rsl7129227 GCAGGAGACTCTAACA[G/T]CTCGTGGTCCAATTCC rsllO3O292 GCAGGATTCTTGAAAT[C/T]ATAGAGCTGGAAGGGG rsl7117193 GCATAGATAGATGGTAIA/GJCTATGGAAACAATATG rsl7015855 GCATAGTCAGAGTGATfA/TjAAAAGATAAAACTGCT rs2944542 GCATCCTTCCAGATCAIC/GJAGAGTTTAGAGCATCC rsl6971961 GCATGATGGATTGGCAIC/TJAAAGGAGGTAAAGTAG rs7200121 GCATGGACTTCCCACA[A/T]ATGTTTCTGTAGCATT rsl7835780 GCATGTGTTTACTTAA[C/T]GAGCTACTTTCAGATC rsl39932 GCCACACATAACTACC[A/G]AGTGCCTGCTGTGTGC rs873454 GCCAGCTCTTGAAAAT[G/T]ACGCCTCTTACACTAG rs733803 GCCAGGACAGTTAAAC[A/G]AAACCATCATCACCTC rs4375697 GCCATCCTGTAGCTTC[GA]CTGCTATATmTATT rsl7610429 GCCATGGTAATAAGTA[C/G]CATCCTGAATCAGATT rs293043 GCCCAGACTTTACCAC[C/T]ATGCAATACATCCATG rs7300605 GCCCAGCATTAGGTAG[A/G]CCGTGTTAAATTAGCA rs2062004 GCCCAGCCATAGGTTC[A/C]CGTAACTATTCTGAGC rs6988923 GCCCAGGGCCTAAAACfA/GlGTCAGCACAAAGCCTC

rs3799195 GCCCCTCAGCTGTAAA[C/T]TCCAGAAGGGTCTATG rsl7129234 GCCCTGCAGCTGCCGA[G/T]AGGTGCAAGGAGATGC rs4659404 GCCTAATCCTCAGCAA[A/C]TGTTCTACCACTCGCA rs4664900 GCCTACATCAAAGTAA[A/G]GCTGTGAGAATGAAAT rslO425517 GCCTCAGACATTTGTA[C/G]CACCGTTAGTCCTGCC rs4724427 GCCTCAGGAACAAAGA[C/G]AAAAAATTGACAGGCT rsl7166013 GCCTCCrCTTACTCTA[C/T]GACCCTTGGTTCTGTT rsl0456081 GCCTCTATCCTAAG AG [C/T]CCCACGTTTATTTCTA rsl424028 GCCTCTTAGGTAGTAA[A/G]AATAATGCAGAAGTAC rs645257 GCCTGCAGTTAAGGAG[A/G]CCTGG AG AGCAGCCGG rslO194748 GCCTTGGGTTGCACTA[C/T]GAAACTTACACAACTG rsl3428236 GCCTTGGGTTTCCCCA[G/T]GTCGTTCTAGCCTGAG rs7718757 GCGATCCAAGGAGCGA[A/G]CCAGTGCGCCAACAGT rs6718656 GCGGACCCAATGTAAT[A/C]AGAAGCATCTGTATGA rsl563654 GCTACAGCGAAGAGAT[C/G]ACATGAGGAAGTCAAG rs2575656 GCTAGGGAGGAGCAGA[C/T]CTTGTTTAAACATTTG rsllO27761 GCTATTTTCATTGCTA[A/G]TAACATCAGGCCTTTA rs4964583 GCTCACTGACAAAATA[A/G]AACAGGCGGAGGCCAT rsl2500918 GCTCAGTCCAAAAGGA[G/T]GCTTATATCTGGCTTA rs7295752 GCTCTTCATTCAGTTCtC/TJCTGTTAGATGTCACCT rs9573762 GCTGCAGCACCGTTTA[C/T]GATAGCAAAGACACGG rsl0956606 GCTGCCATAACAGTAT[C/T]ACAAATTGGGTGACTT rs822129 GCTGGCAATGTGAACA[G/T]GGAGCTTGACTGTCAA rsl451392 GCTGGCACATTGGTAA[A/C]ATTAAGCAATGGCAGG rs7724743 GCTGTAGAGCCTGGAA[G/T]AATCAACTTAGAATCT rs4473456 GCTGTGAGCACCCTAC[A/C]AAATGACCAGGTACAG rs7422960 GCTGTGGAAGCTCTGA[A/C]CTTTTAGACTTAACAC rsl0937121 GCTGTTTACAGTAACA[C/T]AAGGAGTCACGGTAAC rsl975275 GCTGTTTGCTTCTTCA[A/G]GTCCAGAAGGGGAATC rsl985147 GCTTAAAGACAACACA[A/G]AGGCTTTGGCAAACTG rsl2097397 GCTTACGAGAACAAGA[C/G]GAATAGCTAATTGGAG rs4939364 GCTTCACAGGCTATAA[A/G]GTACTACACTGTGGTC rs9402839 GCTTCCATAGTTTGTA[C/T]GGCAAAGTCTACTGTC rsll213020 GCTTCTACATTAGACA[C/T]GATCAGCCGAAGAAGG rs273439 GCTTCTGTTTTAGCAA[C/T]GGGCAGTCTAGCTTTC rsl3034681 GCTTGATTTTAAGTAC[A/G]GATAGTTTTACCTGAT rs6664026 GCTTGCAAAAATTCTA[C/G]GTTAGCCAGGCATGGT rs2281634 GCTTGGCTCTTCTGTA[C/T]AAAAAAAGACTTTTGC rsl2345926 GCTTGTATTTTCCTTA[C/T]GCTATGGTTAGATATT rs2812533 GGAAACAGGGCAGAAC[A/G]AACTAGCAGCACTCAA rsl2618490 GGAAAGTACTCTCCGA[C/T]CTAATTTGTTTCATAG rs6965416 GGAACATCTCGAGGGC[A/G]GAAGTCGTG I I I I I I I rs4976682 GGAACTGCTCAAATGA[A/G]ACTCAGCAAGAAAGGG rs4804931 GGAAGCAATGACATCAIA/CJGTTGGGGAAGGAGAAG rsl37947 GGAATA I I I I I I IATC[A/G]CTGTCCATGTTTTGAA rs4508405 GGAATCAGTTATCATAIC/TlAGTCAATTATTACTGA

rsl7166584 GGAATGACCTGTAGCC[A/G]ATTCCCAGAGCAAGGT rs2281649 GGAATTGATTTTCCAA[A/G]GTCTGTGCCTACATGG rsl0950377 GGACACTCTTCATTGA[C/G]GAGAGCAAAGACAGAC rs4918207 GGACTGAAATTGATGCIA/GJGATGCAAAATAGCATT rsl7082355 GGACTGAATTATGTAA[C/T]GTCATAAACCAACACT rs3131038 GGAGACAGGCTGGACA[C/T]AGCAAAATCTTGCCTC rs9371205 GGAGAGAGCAGGAAGC[A/G]CTGGGAAATAGCACGT rsllO67427 GGAGATGTAAAAATGA[C/T]TAACACACAGTCTTTA rs7120203 GGAGTTACCATGACAA[A/C]GCAATAACCTAGTTTC rsl915847 AACTCACAAATATGGC[C/T]ACTGA I I I I IAACAAA rs7125458 GGATTCCTTCTTCTGA[A/G]AACATCTATATTCTTT rs4960103 GGCATCATGAGGATCA[C/G]CTGTGTATCTGTACCT rs7404786 GGCTAGGAATGAATAA[C/G]TGACTTGCTCAGAGTT rsl6864685 GGCTCCATAATTCTTC[A/G]CTGCTCTACGAAATCT rs262055 GGCTGTCTTTCCACCA[C/T]TACAGCTTCGCTCGTG rsl887589 GGCTTCCGGCAGCACA[A/G]TATCACCTATGTTCCA rsl952537 GGGACACAAGCTTTCA[C/T]CAAAGAAGCAAATATC rs747088 GGTGAATCTGTGTGAA[A/T]CTGGGTTCCAGATGGG rsl2903540 GGTGGGGCTTACACTA[G/T]GGGACACCTTGAACCC rsl500071 GTAAACAGGGACAACA[A/G]TGGGCATCGTTAGAGA rs2449166 GTAGGAAAGGGGAGAqA/GICCTTATTGATTTGATT rs6496045 GTAGTACAGGATGATAIC/TJATTGAGAAGAAAAAGA rsllO76564 GTCAACTAAGCACTAA[A/T]CCAAACAGGAGATTTT rsl698912 GTCATGCCAGGTGAAA[A/G]AAGACCACATACTGTA rsl526285 GTTAGCAATTAGGGAGfG/ηAGTGAAAGAAGCAAGT rsl857705 GTTAGCATTTCTCAGA[A/G]GTCCATAGAATCTGTC rsl6953567 GTTGTACCTACCCAAC[A/G]AGCATTCCTCTCTTCT rslO514437 TCAAGTAGTTTTGTGA[C/T]GGAAGTAAATTAAATG rsl3347176 GTTTTGGAATACTCAA[A/G]GCTTTCCTTGGTCAGT rsl0787379 TAAAACCTCTGCTGGA[G/T]AAAAAGAAAGGGGGAC rsl7184032 TAAGCCTCCTCTTCAA[A/G]CACAGTGGCATTGTTC rs4461518 TAAGCTTGTATTACTA[C/T]CTAGGCAAI I I I I I I I rs6050664 TAAGGGCAAAGGATCC[A/G]AGGCATTTATAGACCA rsl0804476 TACAGAATAGCTAAACIA/TJAGAAAGTGGTACAGGG rs6793934 TACTG CTACT ATCTG G [C/T] ATCACCTATTCAATTC rs2745945 TAGATCCCTAGCCCAA[A/G]GTTCTGTCTGCATAGA rs277481 TAGGGAAACTGGGTTC[C/T]AGAAAGGACTGATCAT rs4794293 GACGTGTTAAGTTCCA[C/T]AGATAACAACAAAGTC rsl7067532 TCAGGGTAAAATAGGAfC/TjGAAAAGAGTAACAGTG rslO515O37 TACTTCATTTGTCTTA[A/C]GTGTGTATTTTTGGCT rsl0055946 TCATGGTGATGAAGCC[A/G]CAGCAAATTTCCAGAG rslO515O9O CAACTGTCTTACAGGA[C/T]GGTAACAAGATAGGCA rs4562759 TCCCTCCATAATTCCA[A/G]TGAAAAACCACTTAAT rsl466696 TCTGAC I I I I I CCAAC [C/T] CCCCTGTATG GTATAA rs644025 TCTGGAGGTTTGGGTAIA/GIAGAAAATCAGTATTAA rsl0180434 TGAGAGGGAGGATGAAIC/GJAGAGGTAGGCTACTGG

rsl7121339 TGATAUCACTAGGAA[A/G]AAGAGTTCCTATCAGC rs2394401 TGCCACTAGGCTTTGG[A/G] ATG AAATAG ACCTAGG rslll52133 TGGGCAAGTATACCCA[C/G]GTATTTGTGTTGTTCT rsl7310125 TGTATCATGATTATGC[A/C]CTTGTAGATGTACTGA rsl0494011 AAGTTGCAATATTCCA[A/G]GTAAGAAATCAGGTGG rsl0906541 TGTTGCCTGCTGAGAA[C/T]TGAAATACTGAAAGTT rs6126086 TTAGACAACTTTAAAC[C/T]CTGATTCATAAAAATG rs921423 TTATAGTTTGGCCCCA[A/T]CCTTTCCTCTTGCATA rs2596477 TTCCATATTCTTGACA[A/G]TATTTAGACTTATCCA rsl7782247 TTTGTGTCATAACAAA[A/G]GTGAAATTTCTGATCC rsl2711507 I I 1 1 I I I I GTAGAGAC[A/G]GAGTGCATAGTGAAAG rs2309582 AGTATTATCAGCACCT[A/G]AACCTGAAAAGATTTA rs3769956 TGTGCAAGTTGGCTAC[A/G]GACTGAATACAAATGT rsl6980299 TGGCTCTTGGAATAAA[C/T]ACCTCAAGGTCAGGAA rsl033547 AAAGTGTG AACAAAGG [C/T]ATCATTTACAACATTT rsl0494390 ACTAAATGGAAAGCAC[C/T]GTGCAAAGAACTGGAT rs935970 TCTCTGTGTGTGTTAC[C/G]GGAAGTCCAGAAGTGC rs9306942 GAGAACTATACATCTA[A/C]GTCATAGCTCTACACA rsl540513 GGTAAATATGAGAAAAIA/GJAATAGTTAGCGTTTGG rs2175458 GGGCTTGTCAAATGGA[A/G]CCTTCCGCACTCCCTC rs7660477 CACCTAACTCAACACA[A/G]TGTAATTTGCAGAAAA rs30446 AGTATCACAGTCATGA[C/T]AATTAGCTGTACAGCT rs607145 CGTATCTCAAGTTGTA[C/T]AAGTTTGCTGCACAGA rslO519769 AAATTTTAAAAGAGGC[C/T]CATGATATATTAGTCA rs3910183 CTTTCCTTATCTCTAA[G/T]TTAAACATCTCTATTT rsl7063216 AGAAATGAAGTCTCACIA/GJCAGATAAAATAAGTCA rs950922 TGAGGCTCCGATTGTA[C/T]TTCTAATAAGCTCCCA rs937090 TAGCTAAGAAGTAGCT[A/G]AGCCATGATACAAACT rs9285474 GGCTTGAGGAATAATGlA/ClAACGTG ATCTCAAG AC rs288968 CCCGGATTATGCTGAA[A/G]AAGAGGCAGGGTAGGG rs622342 ATTTGATGAAAACTTC[A/C]AATACATAGATCTAAC . rslO486591 CAAAAGGAATCCAATA[C/T]GTGCATTGTGAAGCCA rsl0485902 GTTCCCTTAATACTTA[A/C]CCATGGATGTGTTTGC rslO487169 ATGGTGAACTTCCTAC[A/G]GGCTTAGAAAATTTGT rs2106900 TTTAATGCCAAAGCAG[A/G]AAGGGTCAAATTGATT rsl0487754 TTTAGAAACTTCTGAA[C/T]TGATATTACATTGCCA rsl0505491 AGCATTTGCTTAATCA[A/G]AAGGAACAGTGCACCA rs2006996 GTTATTCCCCATATTG [C/T]G ATGGTAGTAG AAACC rs7416006 TGAGAACACCAAATAC[C/T]AGTGAAGATGTAGAGT rs224053 GAAATGGGATTAGTCA[G/T]CCTGACAGATTATTGA rsl0509376 TTTGAATCATCCAAAA[G/T]CCATCTGAATACACAT rs6497269 AAAGGCGCCTGCCGCA[C/T]ATCTTGAACTGCGGGA rsll844425 AAAAGGTGAGGGATGAIC/TIGATACTGAGCTTTTAA rsll829539 AAAGTCAGATTTTCCA[C/T]GGAGTCTTCATCAACC rsl7381294 AAATATGGCTTTTTCA[A/G]CTCATTATATTTCTTC rs2900402 GGAAATTAGGATACTA[A/G]GATACTACAGTCAGTG

rs4836172 AACATAACCTGTTTTA[C/T]GTGAGAAAATAGGAAG rsll256896 AACCAGCTCTTGAAGA[C/T]AGTCTCAGAGCCTAGA rsl7583338 AACCAGTGAAGGCCAGIA/GJATGCCTCAAAGGTCCC rs7567851 AACTCAGATTCTCTAC[C/G]ACπTAAAATTTATTG rsl633920 AAGAAGTCCTTAGAAA[A/G]GAATGCTTGAGCTAAC rs41365145 AAGAATGAATGGATGA[C/T]ACCTAGCAGTTCATTT rsl6836896 AAGAGGTCTGACTTAA[A/T]AGTTTTCTGTGTGTCA rs6825049 AAGGATTTGAAATGCAIA/GICTTAATCAAAATGAAA rs7936903 AAGTCATTTAATACCA[C/T]TGAGCTTGTTTACTCA rsll880216 AATAAATTGGAAAAAAIA/CJATGAATTGGAAACACC rs2359005 AATAGCTGCTACTAAC[C/T]AGTCCTCCTCACACCC rs7628755 AATAGTTTTGTTCATA[C/T]GCTGGTTCTTGCCCTG rs6992733 AATCCTAGCTCAGTCA[A/C]TACATTGTTGCATGAT rs2707797 AATGCTGAACAAAACC[A/T]CATTATTGATTTGATG rs4659576 AATTACAATTAAACCA[C/T]TGATATTTCCGTGAGA rs903586 TGGG AG AG ATGAATAG [C/T]ACACCGGGCTAAACAT rs2486872 ACATATACTGTAATAA[A/C]GCTTGAAAATCACAAA rs6667442 ACCTGGTGAAACTGAA[A/T]ATGTGTATGCCCTTTA rs3122227 ACTATGTGAGATGACA[A/G]ATCCATTAATCTGCTT rs300906 ACTATTCAGGTGAGAA[A/G]AAACAGGTAATAAGCA rsl6945869 ACTCAAACCACTCAG G [A/G] CCC ATTTTCC AAC ATT rs7743142 ACTGGAAATGACTTAAIA/TJAGTGGTTAAAATGGTA rsll01053 AGAAAATAATTTCCAA[A/C]GCAGAATTTTCGTATC rsl6858402 AGAATTGCTAGGATAC[A/C]GGATACACATAGGTAC rsl6974720 AGACCCAGGCAGGTGA[C/T]GCTTGTTAACCTCATT rsll906089 AGAGACCCCAGGTCACIC/GIGATTACAAGGTGCCAC rs3103239 AGCAACL I I L I I I GCA[A/C]CTGCAGCCTTAGAGCC rs2111368 AACTACTAACTTGACA[A/T]CACAGAATATGGGGCT rsl3022081 AGGAGTCTAGTGTGAA[C/T]AGCATTTGCTTATCCT rs4706754 AGGGCCTTATAAATGC[C/T]AATATTACCTGCTGGC rs6552883 AGTATGGATCTCTTGC[C/T]AAGCTAAGAAAAGTGA rs7742460 AGTGAACAGATATTAAIA/GJAAGTGTATATTGCAAT rs7301125 AGTTTCTGAGTGCCAA[C/G]AGTGTTCTCTGTTTTA rsl7081351 ATAATGGTGTCTGGTA[AZG]AGATATAATGGAGCTG rs4643957 ATAGAGCAGGTAGTCC[C/T]GAAAGTGACCCAGGAC rsl0751821 ATATTAATCTAGACCA[C/T]GCAGTGCTGGTAAAGA rsl2247225 ATCAAATATAGTTGTA[A/G]AATTTCATGACAGTCT rsl2661572 ATCACTGTGACAGATC[C/G]AATGATGGGTATCAAG rsl202519 ATCATATATCTGCTAA[AZG]GGATCACTATTCAGAA rs4986239 ATCCTGTGACCCTCTA[A/C]AGTTACCACAATTTTA rs2997195 ATGAAAATTCCTGTAA[A/G]GGTGTAAAAGGACCAT rsl2480756 ATGAATTATGCTCAGG [A/G] ACAATG ACTTAAACTG rs4430079 ATGTATATTAAGAGTA[A/G]TAACACTGATGACACT rs913201 ATGTGGAAACTTTTAC[C/T]ACGAATTAGGAAGAAC rs2048756 ATGTTC I I I I IGATTC[A/G]CCATCACTAGGTTCTT rs6790852 ATTCTCAGGCCTACAAIA/GIGTCTCAGTAGATAATG

rsllO83515 ATTTGCTGTTATCCAC[A/G]GTCACTCAGCTAAACC rs3003202 ATTTGGTAACTATAGG [C/T] ACG ACGTTGCACAG AA rsl885506 CAACACCCTGTGCATG [A/G] AAAGCTACAATCCCAG rsl2624187 CAACTAAACTGATAAA[C/T]TGATCTGTGGCATGAA rsl6856939 CACAACTTGTATCTTA[C/T]GTATCTATTAGGCATG rs9516304 ACTTAAAAAAAAATCA[A/G]CATACTGAGATATACA rs9538452 CACATGGAGTATTTTC[C/T]AGAATAGACCATATCT rs7334911 CAGTAGAATAATAGTGlC/ηATGAGTTATTGTGACA rsl2878600 CACTAGCCAGAACCCA[A/G]ATAATGACTGCATTTA rs6684672 CACTGACCCTCTCTGA[A/G]CCTCATTCTCAAGGGT rs917986 CATATAGGAGATATCA[G/T]AATCACCTTCTTGGGA rsl6905844 CATTAGGCCCTATTTA[C/T]GCCTGCAACAATCCAA rsl936393 CATTTTCAAGTTGAAC[C/T]AAACAATGGAAGAAAA rsll220695 CCATGCAGATTCCCAC[A/T]GTGAGATGTGTTGGAC rs8099594 CCTGACTGCCCTTCCC[C/T]GGACAGGTTCTGTTTG rsll242303 CGCAGTAGCTCTCAAA[A/G]GAGACCTTAGACTGCC rsl6839700 CTAGACAGCTGAATCA[C/T]GTTAGACTCTATAATT rsl564121 CTCAGAACTCAGTAAG[C/T]ATTTGCCAGATGAATG rs8182488 CTCCTAAATGGATTAA[C/T]TGATGTTTCCTTAAGA rsl0988690 CTCTTGTTAGATAGCA[C/G]AGTCATTTTCAAAGTG rsll217506 CTGGGCTTTGCTGGAC[A/G]CGCTTTCTGTCGTGCA rsl2577796 CTGTTTGGTGAGGGTC[G/T]CTTTTCCCCTCCTCTT rsl0829910 CTTGTGAACCCTGGCA[C/T]AATCGATACACATTTT rs2714555 CTTTAAGGAAATGATA[C/T]GGCTCCAAGGCCAGGG rsl707421 GACAGCTATAATTCCA[A/G]AGGGAACAGGACACTG rs2650972 GAGAAAAGATGAGAAAIA/GJGAGTGGGCACTGAACA rs7140324 GAGCAACAAAATGCGG[A/G]AAAAAAATCTATCTTT rslO844251 GAGTTATTTGGCTTTA[A/G]AAAACCACACAACTTG rs2282658 GAGTTTAGAAATGAAAIC/GJTGTAGGTAGATCACAG rs3845391 GATACAAGACTATAGA[A/C]TCAAGAAGACCTTGTT rs9480304 GATCTATTTCTCCTTA[C/T]GGTTCTCAGTTTTTGC rs2699494 GATGTCAAGCATCAGC[A/C]GAACATTTTGGAAAAA rsl496036 GCCAGTAAAGCACAGC[A/G]AGAGTAGTAGAGGCTA rs6133374 GCCCTGTTAGGAGGCA[C/T]AGGGGCTTATCCATGC rs7462490 GCTATTGCAGCACAAA[G/T]AAAGATGTCTGCATCA rs3746192 GGACGCACTCACTCTC[A/G]GAAGGGGAGGAAGATC rsl206873 GGAGAATCACCTGAAT[C/T]AGGGAAGCAGAGGTTA rsl962684 GGAGCTATACTAGGAA[A/C]CCTTGAAGAAAACACC rs626987 GGATTGGCTGAAAAAAlA/ηTCTCTGAGGTGTGATT rsl0192117 GGCCCCCACCAGATAC[A/C]CTTTAATCTGCCAGGC rsll854975 GGCCTGCATCGATCAC[C/T]GAAATAGCAGATGTGA rs296410 GGGAAGACTTTGTGCA[C/T]TGAGACTTAGACAAGT rs6431549 GGG ATGTGTGTCCTTA[C/G] ATCTGTG AG AGGTCCT rsl86385 GGGATTACATTTAGGA[G/T]CTACATGGATAATCCA rs2314348 GGGGTGTGAAGAAGAA[A/G]ACCTGGAATCCGACTT rsl0987807 GGGTGAGGACACTGAAIA/GJGGTGAAGGGTGAAAGA

rs35452680 GGGTTAGAATGGATAT[AZG]AAACATGAGGTAGGAA rs3759320 GGTGAAACTACTGGAT[AZG]AGAGAGATGAGAGGCC rsl6853196 GTACAATGTCTAAAGG[A/C]ATGGTTTTAGCTTGCT rs4739348 GTAGTAAAACTCCTTA[G/T]GCTGATTGCTTAGGGG rs7433574 GTCAGGAACTGCAGTC[AZG]AAGTTCAAATATTAGA rsl6953091 GTCGGATATGCAAATA[C/T]GGGCCTTCAGACGCTC rs6606891 GTGACACTGGATGTTG[C/T]AAGACAAAGGGCCTGG rsl2578573 GTGACTGCCCCGCTCA[AZG]GACAACAAGCTTACCT rs4626339 GTGATTATTTATATGA[AZT]AAAGAGCACAAACATT rslO134537 GTGGTGGCTTTGGCAA[CZT]AGGTGAAGTTTGGGGG rslO871567 GTGTGGCCTGAGATGA[C/T]GATCACAAGGACACAA rs888928 GTGTGTTTGAAGGGAA[C/T]GGCCCTTGATGAGACA rsl2639772 GTGTTCACACATTCAC[A/C]CTTCTCCATAGTGACT rs7199368 AGGTAATCTAAAATAC[AZG]AAATAGTTGGCTGTCT rsl7495366 TAATCATTAGGCTTCC[C/T]AGAGATTTTCGCCTGT rs6585151 TAATTAAG GTACCTTA [C/T] CTAAG ATTTCAG CACT rs3775758 TACCAAAGTAAAGTAG[AZG]AGCAGTTAATTCAAGA rs8101967 TAGAATCTGTTTTACA[C/T]AGAAGCAAAATGAAAC rsll748341 TAGTGCCAGGGAAGCA[AZG]CGGGGGTTCTCACGTA rsll660123 TATACTTTACCTTTCC[C/T]ACAACAAGGGCACGTA rs9913546 TATCCTTAGTAACATA[A/C]ACTGAAGGTTTTAGGA rs9399247 TATGTCTTCAAAACCA[C/T]TCCAGTGTGATTTCAC rsl0217225 TATTTTCTGAATTAGA[AZG]AGCCTGG AGCAGGGGT rsl670725 TCAAATGGCCTAAACAIA/GJAAGTCCTCCTACTCCC rs7748388 TCACAGAGCTCGCAAA[GZT]TCCCACCTGTTCGTCC rs4751376 TCAGCCAGAGAGCAGC[AZG]AATGTTAAGGCTGGAG rsl7266983 TTAGTTCCACTGCCTC[CZT]AGCTTTCCCTACACAA rsl6937906 TCCAGAAATCTATAAA[AZC]ACCCGGAAATGACTGG rs6442271 TCTAGAAGCCAAGTTC[CZT]CTTTTCCTATATTTAA rsll717189 TCTAGGGTATTCATGA[CZT]GAGGGAAACAGAACAT rs4555525 TCTGAACTGAGGACGC[AZG]ATATATTTCATGGCCT rs942666 TCTGCCCATTTTAAAA[AZG]CATCATATTTAGAAAT rs6051642 TCTTCTCAGGGAACTA[AZG]ACAGGGGCTGCTGGTT rsllO75994 TGAAGCCTTCACAGAA[CZT]ATGTAGTGTTTAAGTA rs6040798 TGACTACAAAGAGTAC[CZT]GGACTGGCTCTGGAGA rsll711956 TGAGTCTGTCTCCACC[CZT]AGAGAAAAGTTGCCTG rsl864180 TGCCAGTCCACTATGC[CZT]AACTTCTGATTAACCC rsl0847773 TGGACATCGAGAAAAC[AZG]GAACCCTCATCTGGCC rs4785346 TGGATTGGACTCAGAT[AZG]AGATGAGTAAATGCAA rsll207506 TGGCCTCATGGTTAAA[CZT]ATACCATTCATTCGAC rs7382649 TGGCGTGCTCCTAACA[AZG]ATGTTCAGACAGAAGG rs4987082 TGGGAGCCGTGGGATC[AZG]GAACAGAGTGTTCTAG rsl2629074 TGGTCAGTTCTACCTG[AZC]AGGTGTTGAGCCTGTA rsll223291 TGGTCATTCTGTTAGA[CZT]ACTATAGTGAGACCAG rsl2608562 TGGTGTCTGATGTCTC[GZT]CACTAAGCATGGCATC rsl0747873 TTAAGGCCGTGATTGA[AZC]ATCAAAACAATCTAGA

rs7148698 TTACCCCAATTTGTTG [A/C] AGCATATTTGTCAGGC rs6003482 TTACTTCCCCAAGTTC[A/G]CAGATATGTmTAGG rsl541974 TTCAAGAGGGCGTTCA[A/G]AAACAAAAGAGAATGC rsl7151967 TTCAATAGCTTCCTCA[G/T]CAACTAGCAATAACCA rs4926528 TTCATrCCTTACTGAA[A/G]TGTGCTCCTCCTAACC rsllll224 TTCCAATL I I I I L I I C[A/C]ATTGCCACAGAGCATC rs7766133 TTGATGTTTGATGTTAIC/TIGGGCAGAGAAAAATAC rs8000744 TTGTTGTTG AGTAATG [C/T] AATCTTATCTTCATGG rsl2003560 TTTACTTCATCCATAA[C/T]AGAGTGGGACGCATTG rs4951536 TTTAGGGGGCCTCTTC[A/C]AGAAAAAGAATTTTAA rsl0905648 TTTATATGGCAGACAG [A/G] ATGAATG AGGATACAT rsl0764066 TTTTAAATATCCATAC[A/G]ATGCAATACTACTCAG rs2818047 I I I I L I I I I CTTCTCC[A/G]CGACTGAACAGATTTA rs722035 GTGTGGATCCAATGGT[C/G]ACCCTTTAGGCAGTGG rs719874 TGGAGACCCTAGCGGA[A/G]AGGGGTTCAACATGTA rsllO6184 CTCTCCCACTTTATTC[A/G]GAAGTTCATATGAGCC rs9287767 CCAAATCACTCACTAA[C/T]TGGCAAGTAGTAATAG rsl7036800 TGACCAGAAAGGAGAC[A/C]CTGTTTCCACACGGCC rs4953864 CTCAGTGAATGGGAAA[C/T]GGAATTAAATATATCT rsl0497840 CTCAAAGACTCACATA[C/T]GACAGCGGACAAATCT rs9283537 AAAAGAGGAAAGACTAIC/TJAATGCAGAGTAGAAAA rs6726527 GTTAAATATGTAACCA[A/C]ATGTCTCAGTAGAGAA rsl64123 TCTAGAAACCCAGGAA[C/T]GTATCTGTGCTGCAGC rs6776332 TCTAACCAGTAAAGAG [A/G] ACCACCTGTAATTATG rs760650 AAAAAG ATG AAAG ATG [C/T] ATGCTAAAATCAGGCT rslO516294 CTTGATAG I I I I IAGA[A/G]AATTCACTTTCAGCCT rs3775442 TAACCTCTAGATAAGC[A/G]CCTGTCCAGAGGTTCT rsl372680 GACTTTAGCCAGGAATtG/ηAGTGTTAGGAAAGAGG rs2200733 GGGTTTTGATTTTGATIC/ηAGAGAAAATTAGAACA rsl358229 TGTGTGTCTAAGGACC[A/G]GAAATAATCTCCATGA rsl0494829 TTTTGCTAACGTAACA[C/T]GTACCTCTCTAGGGCC rsl891174 GGGAAGAATCCAGTCA[C/T]TATTTGGTTCCCAGAC rs955323 GCTGAAGCAGAAATCA[A/G]TTATGCCTGTGTTGTT rs4129540 GCAAGAGTGAGAGATA[C/G]CTTAAATTATGCCTTT rslO515588 GGACATAAAAATATCA[A/G]TAAGACAGCTTTCCCT rs200995 TATGTCTTCACCTTGT[C/T]AAATCAGTCAGAGAGA rs41398948 GCGGACAGTTGTCAGT[A/T]AATTGTGGCCTCAGCC rsl0736952 CAGGCCTGCTTTATCA[C/T]TGAGCTTGAATCTTAA rsl7119141 CTAATCATTCTGTTGC[G/T]ACTGAAGCATTCATTT rs7828354 TGTTTTGGAAATAAACIC/ηGGCATATTAGTAAGTG rs2439525 TATATTAGGTCTCATT[A/G]AACAGCCCAATGAAGC rs2026037 TGGGTCTATTCACATA[C/T]CCTTACTCACCTGCAG rs2043556 ACTATGAGATTTAGAA[C/T]CAAGTTAGGACTGCAG rs7335157 ACATTTGCACTGAAGA[C/T]AAATTTCTCACTGACT rs226864 AAAGCAATTGAACAAA[G/T]ATGGGGCCACAGATGA rsl7097516 ACTTAAATTCACTCTC[C/T]GACCACCTAAACTCCA

rs6554987 AGATAAAATGCTAAGG [A/GJCATG ATTCATAAAATA rs2407490 ATACCTTCGATGTAAA[A/T]TATATTGTGCTTTGAG rs4817505 CTGGGAACAACTCAGA[C/T]ATTAATTTTGAAAGCA rs2836808 CAGTATGTTGAAATAC[A/G]GCTAACAAAATGTAAC rs2836824 GAAACAGTGGAAACTC[A/G]CCCTTTGTAAAAGCAG rsll225166 AAAAAAACCAGGTCAT[C/G]AGGTATAATCTTTGAT rs2153904 AAAGCCTTACAGGCCA[A/C]TGAGTTTGAAACCCTA rs7739965 AACAAGTGACCAGCCA[A/G]AGAAAGACAGCCTAGT rs4548690 AACTGAGAATATTCCC[A/G]AATTTTTGAACCCATG rsl3242757 AAGAACTTACTTCCTA[C/G]AGGGAAATCAGGTTCG rsl7434789 TGACTTGACCTTCTCA[A/G]CTCGGGCATCCAATCT rs764255 AAGACCAGCAGCTGTAIC/TJATTAAGCACTGAAATT rs6866221 AAGCACTTTGTTGTTC[G/T]CTAACTCCAGTAGGAA rsl7103286 AAGCCCATTGGTGTAC[A/G]GAGAATGATGTATGCT rslO5O6132 CCAGTGTGAATCCCTA[C/T]AATGGAACACGTTAAA rs4768204 AACAAGATGTCGGCCC[A/T]AGTTCTCTCTCTAAAC rs2667092 AAGTTTAAAAACAAGA[CZG]ATTGTACAGAAAGAGG rs4684003 AATCTACAAGGTGCAG [A/G] ACAAAAGG AGCAGCTA rsl6944836 AATGTTGGTTTATTTC[A/G]CAGGCGCCCTGAACGA rsl805543 AATG I I I I IACCCTCA[C/T]ATTTTACAGTTAGAGA rs391196 ACAAGAAAAAGCTGAA[C/T]TCCTTGATATGAACCT rs2980571 ACACTTGAAATGTATC[A/T]CCCCTTCAGTTAATAG rs4480084 ACAGAGTTCTCAGGGA[A/T]AACGCCGCGAGTGTTC rsll356366 ACATCAGGGGAAAAAA[AZG]TTGTAGATGATGATGT rs2906407 ACATTGAGACGATGCC[C/T]GATTTTGGCAACTGCC rs6415846 ACTAATAACAACAATG [A/GJCAATAGTAACAACAGC rs383855 ACTATAAAACCTCACA[C/T]AGTCATTATTGAAGTT rs41390346 ACTTCCTGTTCTGACA[C/G]GTGCTTTTAACACTTC rs9462082 AGAAACCCTTTGTGGA[C/T]GCCTGTGCAGATGCTG rs2284897 AGATCCAATGGACTTA[C/T]ATATCCAACTGACCTT rs4800508 AGGACAATCCCACTAA[A/C]AACAATCCAGCTACTT rsl6960381 AGGAGGGAAGACCTAA[C/T]TCATGAGGGATGGGAC rslO2O2611 AGGCAAGGCTTAATGC[G/T]AAACTTTATTGGGAGG rs7779218 AGTAAAGACAGTTCAC[C/T]GAGGGGAGATGACTGG rs2607258 AGTCTGTGACTGTACA[A/G]GAGTGTCTGTGCACCC rs8031153 AGTGTTTGGAAAAGAA[C/G]CTACCTGCCGCAGCAT rs9409567 AGTTTGTAACAGCACC[A/G]AGAAGAAATGGACATG rs2059503 ATAATTGATATAATTT[A/T]AAAAATCCTGCACATG rslO818132 ATACCATGAAGAGAGAIA/TJGGAATGATTGATAGCA rs2808783 ATACCTGCCCTGCAAA[C/G]TACATAAAGCTCTTGG rs6864253 ATAGAAAAGGTGAGAAfA/GJAAAGAATACAGCAGAA rs842400 ACCTCCAGAGCACCAC[A/G]AATACTGGTTTTGGGA rsl7501293 ATATTCTATTCATCTA[C/T]CATCTGAACTATTGAA rs3758723 ATCACTCTTGGTCTTA[C/T]ATAGAAGGAGGTTTCT rsl7645454 ATCCTGCAGGCATTTA[C/T]AGCCCATAGGCACTTG rs6783368 ATGATGCTTCCACGTC[A/G]CTCAAGAGATTCTTAG

rs2414003 ATGG AAG AAATTGTAG [A/CJAAAAGGTGTCAGGAG A rs822682 ATGGGTAGGATTATCA[AZG]GACAGTCCTGGGTAAA rsl3061415 ATTCAATAGTGGAGGA[C/T]GGGCAAAATATCAAAT rs3763114 ATTCCTGTAATGTTCC[A/T]ATTGCTATAATTACAT rs980125 CAACAATAGATAAATAIA/GJTATGCCAAGTAATGGT rs4810082 CAAGACAAAAGTCAAG [A/G]CACTCCTU I I I IAAC rs791655 CAAGTGATGAAATGTG[A/T]ATCTCCTATATACAAA rsl6926425 CAATAATCAAGAATAC[A/G]GATCAATTTTATCTGG rslll50169 CAATTCTTAAGTGCAT[A/G]ATAGGCCCACGAATTT rsl571138 CACAGTGATACTCTGA[A/G]TACTTGGTCAATGGGA rs7517484 CACATCTCCGTTTACA[C/T]AGAAAAATGCTCTTTT rslll97175 CACCAAATAACACTGG[C/T]CAATGCTACATGGAGC rs6752491 CACCTAAGCTCAAGAA[C/T]GCCAGAATCATATTAA rs516810 CAGCTAATCTGAAGTG[C/T]ACTGAGATTCACCCAG rs6472605 CAGCTGACAACCATGA[C/T]GACTTAGAAACCCATG rs8010439 CAGCTGGCAATTTCCA[A/G]CGGAACCCTCTTAAGA rs6592876 CAGGGGAAGAAATTAC[A/G]GTAATGAATATAACCC rs2286960 CAGTTAGTGGGGTGGA[A/G]GTAGAACGTGGACAAC rsl7020271 CATCAAATATTTATCA[C/T]ACTCGTCTAATTTCCT rs294073 CATCTCTCTCCTCCAA[A/G]TCATAATATCTGTTGA rs4365836 CATGACAATAATGTTA[A/T]ACCTGCAAATTGCATT rs9609089 CATGAGATCCATCCAC[C/T]GCAGATGATTTGAAAA rslll93684 CATGGTGTATATCTAC[A/C]ATATTTTATTCATCCA rsll207324 CATTCTAGTGAGGAGAIA/GJGCAAGGAGTTAATAAG rs294230 CCAAAATATAAGGCCG[C/T]CACATGTGG AATTTTA rsl323230 CCAAATTGAAAGCCAC[A/G]CTATATAATGACTGTT rs8073660 CCAAGACGTCAGCTGA[A/G]AAGATTGTGTGCACCT rs512023 CCAATTGAGGAAGAAG [C/G]AAGCACCTGTATCAAT rsl2517669 CCATGAGTTGCCCCCA[A/G]ACCAATTCTTCTGAAG rs308880 CCCAGGAAAAAAATAC[A/G]AACTCATGCACTCAGA rsl276367 CCCTTAGCTGAGAACC[G/T]CTACTCTAGGGCAGTC rs473380 ATCTATATTGAACCAA[A/G]TCTAATATCTATTTGC rsl2580163 CCTCCACTGTGACAAA[C/T]GCATAAATGAAGTTTA rsl6941745 CCTCTGGGACCAAGCA[A/G]GACGTGCAGAGCCACA rs6979902 CCTGCAAAGTCACTCA[C/T]TCTTTAAAAATTGTAG rsl886160 TATTTTGCTAGAAACC[A/G]AGAATCTCAGTATGAA rsl7729462 TAATGTCTCCAGACAA[A/G]GGCCTCATCCTTCCCA rsl935097 CCTTGTTTATAAGCAC[G/T]GATATATGATATTAAT rs769617 CGAAAGCA I I I C I I IA[A/T]CATCAATTATATTCCA rs400973 CGCATACAAAACACAC[A/G]ATCAACAGAGTAAAAG rs566775 CGTCATGGACAGAGTC[A/G]AAAGGCTGCCCCACCT rs2730332 CGTTTTACTAAGTCCT[A/G]AGATATAAAGGTGACT rsllO37744 CTCCAGCAAAATTATC[A/G]AAACACTTTTATGCTC rs2339800 CTGAAGTGGGGGGAATlA/TlATAGAGCTCAGGAGGT rsl417301 CTGTACTCTGGTTAAA[A/G]TGATAAAATTTATGTC rsl384887 CTTAAAACAGAAGAGG[G/T]ATCTTTCACTTTGAGT

rsl2021796 CTTTTCAGTGTCTCAC[G/T]CCAGATTCTTGTGTCA rsl2524859 CTTTTCTTCTTTCTTC[A/G]CATTAGGAATGAGAAG rs6509072 L I I I I I I I CTGCAGAA[C/G]TATTCCACACTTTATG rsl7466684 G AAAATAGG ATAGTGG [C/T] AAACCCAGG AAGTATC rs2306783 GAACACCTACCACACA[A/G]TGTACGCCAAACCTTC rsl7746385 GTGTATATAATTTTTA[C/G]CTCCTCAGCTATGATC rsl499425 GAAGACCACTCTCATC[A/G]CAGCAAAAGCCTTCAG rs3754311 GAAGATGCTGAATGGA[C/T]GCATTTTTCAAAAGAG rsl0967376 GAAGTTGTTCTCTAGGIA/GJATAAAACAAGACTCCA rs2278309 TTATTGGAGTTATAAA[C/T]GACATCCATAATACAA rsl0974527 GAAI I I I I CTGAGGCAfC/TlTGAATAGTGAATTTGA rs2339843 GACCCAATTTGATTCAlA/TlGTTATTTCAAAACTCA rsl7048190 GACTGAACTTGATCTA[C/G]ATTCTTACCCTTTTTC rs9480628 GAGTGCGTACTTAAAA[G/T]AATTGAAGGTCTGGCG rs6901118 GATGAGACTAACTAAA[C/T]AAAGGAGACGGATTTC rs7738330 GCAATTAGTAATCAGC[A/G]CAACTGATGGTCTGAG rs3852515 GCAGAGTAGTTACAAG[A/G]AACCTCTCCTAATTCA rs7195207 GCAGCCAGGAGACCCGIG/TJCAGAGCTATTGAAAGC rs7946749 GCCCCCG AGTGTCTAG [A/G] ACAG AACCTGGCACTC rs4962582 GCCCTCCTGGTGAAAG[A/G]CCTAACATCGAGGTCC rs7551341 GCTAAGGAGAACACGC[C/T]GCCAGGATGTGCTGCA rsl0742277 GCTCGCAGAACCCTAA[CZG]GCATGATTAGGCCTGG rslll95927 GCTGCTTTCTGGCTCA[A/G]GTATGGCTTCTTGGCT rsll748625 GCTTCACTCCTAATGA[A/G]GTTCTCGGACTCCACA rsl6972110 GGAAATAACATAAAGAfA/TlGAGGACGTGCAGGAAG

Table 15

Table 16

Page 1 Table 16.xls

Page 2 Table 16.xls

111

Table 17

AUC

Number of SNPs With biomarkers Without biomarkers

0 0.714 0.500

50 0.841 0.782 100 0.909 0.878 150 0.949 0.929 200 0.966 0.954 250 0.980 0.972

Table 18

AUC

Biomarker Biomarkers independent Biomarkers additive

Atrial fibrillation 0.566 0.566 systolic blood pressure 0.577 0.631 hbaic 0.543 0.631 ever smoked 0.559 0.647

Total cholesterol 0.586 0.667 diagnosis age 0.556 0.699 diabetes years 0.514 0.707 hdl cholesterol 0.534 0.710 sex 0.514 0.713

Table 19

Page 1 Table 19.xls

Page 2 Table 19.xls

Page 3 Table19.xls

Page 4 Table 19.xls

111

Page 5 Table 19.xls

Table 20 rs11810706 rs11810706 rs11810706 rs11810706 rs17562778 rs2481628 rs2481628 rs2481628 rs2502845 rs2502845 rs2590681 rs704829 rs704829 rs791743 rs791743 rs16830446 rs735447 rs7579000 rs1061860 rs1061860 rs12485415 rs12485415 rs12485415 rs1390435 rs1526591 rs1526591 rs1526591 rs1526591 rs1526591 rs1526591 rs1526591 rs1526591 rs16855137 rs17005998 rs17005998 rs17006048 rs17006048 rs17006048 rs17023520 rs17050187 rs17606712 rs17606712 rs1920321 rs6780822 rs6780822 rs7640905 rs7640905 rs7640905 rs7652049 rs7652049

Page 1 Table 20.xls

rs7652049 rs951678 rs9850420 rs9850420 rs9850420 rs9850420 rs9850420 rs10017958 rs10025265 rs1026975 rs1026975 rs12645522 rs13111631 rs13353636 rs13353636 rs13435843 rs1385662 rs1385662 rs1450900 rs17031476 rs17031476 rs2359630 rs2585590 rs29336 rs29336 rs29336 rs4330350 rs4536931 rs7660550 rs7690962 rs7692314 rs7699961 rs7699961 rs11242144 rs1363697 rs1363697 rs320615 rs398934 rs4869544 rs4869544 rs4869544 rs4869544 rs4869544 rs4869544 rs4869544 rs4869544 rs4869544 rs4869544 rs4869544 rs4869544 rs4958117 rs1012424

Page 2 Table 20.xls

rs1014534 rs1924664 rs1924664 rs2260393 rs2261485 rs236369 rs236369 rs236369 rs2452463 rs2814689 rs3019442 rs3846820 rs3846820 rs3914604 rs4710333 rs586124 rs6455807 rs6926642 rs6930668 rs6931162 rs7746960 rs9346035 rs9363771 rs9477555 rs10952491 rs10952491 rs1543265 rs17154998 rs17154998 rs17154998 rs17154998 rs221153 rs6963627 rs6963627 rs6963627 rs886750 rs4736185 rs7828061 rs9325744 rs9325744 rs9325744 rs9325744 rs10979779 rs11142029 rs11999319 rs1340186 rs3793561 rs4310272 rs4310272 rs9886729 rs10998910 rs11193235

Page 3 Table 20.xls

rs11195125 rs11195125 rs11195125 rs11258843 rs11258843 rs11258843 rs11259112 rs11259112 rs12245743 rs12245743 rs1254947 rs1254947 rs1932604 rs1932604 rs1932604 rs1932604 rs2698119 rs4445563 rs4881336 rs4881336 rs7071359 rs7071359 rs7071359 rs7073811 rs7091802 rs908366 rs10765796 rs1878266 rs1406772 rs7969971 rs7969971 rs888152 rs10508010 rs10508010 rs1630807 rs4771911 rs9517529 rs11848645 rs11848645 rs11848645 rs10519051 rs10519051 rs11073505 rs11073505 rs16962997 rs17117193 rs12452883 rs12452883 rs12452883 rs12603207 rs9900205 rs9902506

Page 4 Table 20.xls

rs10439056 rs8094838 rs13040255 rs1891490 rs2426990 rs4347903 rs4812276 rs6013694 rs6013694 rs6081676 rs6129067 rs6129067 rs942989 rs2839580 rs130250 rs130250 rs1489880 rs1489890 rs1489894 rs1844461 rs1873230 rs4821241 rs4821283 rs5749770 rs5749917 rs5754909 rs5755254 rs5755255 rs585124 rs909565

Page 5 Table 20.xls

Table 21

LOC100134599

LOC100134405

LOC 100134384

LOC100134077

LOC100133966

LOC100133876

LOC100133607

LOC100133292

LOC100132013

LOC100131863

LOC100131677

LOC100131632

LOC100131270

LOC 100130999

LOC 100130882

LOC 100130460

LOC 100129848

LOC100129701

LOC100129518

LOC 100129342

LOC100129150

LOC100129101

LOC100128876

LOC 100128648

LOC100128641

LOC100128612

LOC100128283

LOC 100128040

LOC 100127946

RELL1 hCG_1745121

DIRC3

LOC729578

LOC729436

LOC729239

LOC729065

LOC728755

LOC728528

LOC728360

LOC728174

LOC727995

EGFL10

LOC653794

LOC646951

LOC644993

MS4A4E

LOC643339

FLJ43080

LOC642340

RNF165

Page 1 Table 21.xls

PALM2-AKAP2

LOC441239

C5orf40

SAMD12

LOC392288

LOC390637

LOC390282

GFRAL

TNFAIP8L3

ANKDD1A

PLCXD3

VSTM2B

TMPRSS11A

ZNF181

C17orf67

ST8SIA6

KCNK18

NSMCE2

SFRS12IP1

RNF180

WDR62

LOC283867

GPR133

C12orf64

SGMS1

FRMD3

MAMDC2

ZBTB38

FAM83B

SLC35F1

SDK1

JAZF1

PHACTR1

SPATA13

RNF152

DOK6

SENP5

KHDRBS2

TMEM16F

SNX31

COL22A1

FSIP1

GPR180

CCDC63

LINGO2

RLBP1 L1

NKAIN2

PNLDC1

MBOAT1

PLAC8L1

CNTN4

C3orf59

Page 2 Table 21.xls

ZNF385B

LCA5L

EME1

FAM81A

MIPOL1

TSPAN 19

SYT9

TRUB1

ADAMTS 14

MACROD2

LOC 137886

SGCZ

ENPP6

SYNPR

KCNH8

KCTD 18

TSHZ2

UHMK1

ZNF813

CEACAM20

MSI2

C14orf148

FOXN4

CPXM2

MAS1 L

ZNF554

OSBPL1A

CCDC85A

BTBD9

NLRP3

PALM2

GLCCI1

PHF21 B

TMEM183A

DTD1

TMEM132C

STARD13

KCNH7

GLB1 L2

SLAMF9

LL22NC03-75B3.6

UBASH3B

PLXDC2

RNASE7

COL25A1

MAM L2

TMEM117

NLRC5

LRRIQ1

CTTNBP2

PITPNM3

ST6GALNAC5

Page 3 Table 21.xls

ADAMTS 12

DOCK8

KCNIP4

CEP63

ALPK1

FRAS1

TRPM3

SEMA6D

PCNXL2

GRHL2

SCD5

C20orf39

ATP8B4

CATSPERB

ZNF385D

BCL2L14

FTO

PCDH15

TM EM 135

SLC30A5

EFCAB6

DDX31

CCDC136

CSMD1

CENTD3

CHST8

RFWD2

RAB 17

CLSTN2

LHPP

NPAS3

PERP

KIF13A

CCDC90A

SLC22A23

SPCS3

HPSE2

BACH2

WDR19

SLC7A14

CPNE5

CRAMP1 L

SORCS2

MTUS1

NDRG2

SLC24A3

SENP7

PCNP

DDX24

ADAMTS9

ANKS1 B

DPYSL5

Page 4 Table 21.xls

MDM1

EIF4ENIF1

SULF2

C1orf183

THEM2

EAF2

ST6GALNAC1

CACNA2D3

C7orf44

HHAT

FRMD4A

URG4

ZNF446

NAGK

MAM L3

MCM10

LRRC59

CCDC91

C4orf19

RNF220

ARMC4

WDR70

ENOX1

PID1

LPCAT2

FLJ20184

DYM

DCHS2

A2BP1

MARCH5

UGT1A9

EGLN1

UGT1A8

UGT1A10

EPB41 L4B

GFOD1

MRPL39

CNTN5

MYO3A

LRP1 B

ZAK

WWOX

CYB5R1

NAG

LARS

GALNAC4S-6ST

TAOK3

MRPL27

CRIM1

PLCE1

DBR1

SLC45A2

Page 5 Table 21.xls

TNNI3K

FAM135B

PLEKHA9

PI15

PDE11A

IMPG2

SPOCK3

KCNIP1

SEC61A1

NME7

UHRF1

MRPL18

SETD2

SNX24

RBMS3

CYFIP2

NBEA

SMR3A

ERC2

SENP6

AUTS2

CNTNAP2

ATRNL1

ACOT11

MTO1

ZNF324

FLRT3

OSBP2

PATZ1

RIMBP2

AP4E1

KIAA0776

VPS8

DOCK9

SYNE1

WDR7

CLASP1

NEDD4L

LPHN3

KIAA0774

KLHL18

DIP2A

MPRIP

FSTL4

JMJD2C

MYT1 L

PDZD2

TMCC1

PALLD

DIP2C

TCF25

KIN

Page 6 Table 21.xls

ARSG

INPP5F

LAM B4

AKAP 13

SEC23IP

PTPRT

HIBADH

ADAMTS5

POLS

KDELR2

PPARGC 1 A

CHL1

NRG3

CORIN

CUGBP2

HYOU1

VAV3

DLC1

ABCC4

PSMD14

FARP 1

RAD50

HS3ST4

FAM20B

G3BP2

RBM19

SRGAP3

TBC 1D4

KIAA0644

MAGI2

SFH

NOS1AP

TRAM2

DEPDC5

IQCB1

SH3PXD2A

WTAP

CREB5

FHL5

NRXN3

GTF3C4

CD83

STK17A

MAPKAPK2

MAGM

LARGE

CLDN1

PAPSS 1

WASL

MGAM

SYNJ 1

PROM1

Page 7 Table 21.xls

WISP2

INPP4B

CREG1

EIF4G3

TP63

USO1

GAS7

ITGA8

CILP

SORBS2

BBOX1

C16orf35

ADAM 12

BAT2

ZNF66

YWHAE

VWF

USH2A

DNAJC7

TSSC 1

TRIO

TMPRSS2

TGFA

TCP1

SYK

SSR1

SOX5

SORL1

SNCA

SMARCA2

SLC6A2

SLC6A1

ST8SIA1

FBXW4

SELP

SCN3A

RPN1

RORA

ROBO2

RAP1GDS1

RAC 1

PTPRM

PTGFR

PRKCA

PRIM2

PPP2R5C

PPIC

UBL3

PLXNA2

PKP1

PDE9A

PDE6A

Page 8 Table 21.xls

PDE4D

PDE3A

PAX9

PAX7

PARK2

OPCML

ROR1

NTRK3

NFATC2

NELL1

DRG1

MVK

MMP2

NR3C2

MEOX2

MBNL1

LTBP2

LIPA

LIMK2

KIT

KCNH1

JARI D2

ITGB6

IGF1 R

HLA-DQA2

NRG1

GRIA1

GPLD1

GABRB3

GABRB2

FN1

FHIT

FABP6

F5

ERN1

ERG

EYA4

EPRS

EGFR

DPP6

DOCK1

DLG2

DAPK1

DAD1

CTNNB1

CTNNA2

HAPLN 1

COX10

COL15A1

COL13A1

COL6A3

COL4A2

Page 9 Table 21.xls

CNN3

CLTA

CLCA1

CHRM2

CDH6

CDH5

CDH4

CDH3

LRBA

CALD1

CALCR

CAC N B4

CACNB2

BLVRA

BBS4

ZFHX3

APBB2

ANK2

AMPH

AMBP

ALOX5

ALK

ADCY8

ADARB1

AC01

ACCN1

ACAT2

ABCA1

Page 10 Table 21.xls