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Title:
1-フェニルアルキル-ピペラジン
Document Type and Number:
Japanese Patent JP2006502102
Kind Code:
A
Abstract:
Compounds of formula (I) (R and R1 are a wide range of substituents, Q is CO, CHOH or CHOR2, R2 is alkyl, alkenyl, alkynyl or cycloalkyl group, each of which is optionally substituted, or is alkanoyl, alkanoyoxy, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, aminothiocarbonyl, alkylaminothiocarbonyl or dialkylaminothiocarbonyl, R3 is H, alkyl, -alkenyl, alkynyl, cycloalkyl, aryl or heterocyclic group, each of which is optionally substituted, n is 1 or 2, A is a bond or a methylene or ethylene group and R4 is an aryl or heteroaryl group, either of which is optionally substituted) have affinity for serotoninergic receptors. These compounds and their enantiomers, diastereoisomers, N-piperazine oxides, polymorphs, solvates and pharmaceutically acceptable salts are useful in the treatment of patients with neuromuscular dysfunction of the lower urinary tract and diseases related to 5-HT1A receptor activity.

Inventors:
Leonardi Amadeo
Motta Gianni
Ribacaro
Poggisi Elena
Application Number:
JP2004513275A
Publication Date:
January 19, 2006
Filing Date:
June 16, 2003
Export Citation:
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Assignee:
Recordati Ireland Limited
International Classes:
C07D209/40; A61K31/495; A61K31/496; A61K45/00; A61P13/02; A61P13/10; C07C43/315; C07C47/277; C07C49/255; C07C49/577; C07C235/26; C07C255/13; C07C255/56; C07D295/08; C07D295/088; C07D295/10; C07D295/108; C07D295/14; C07D295/155; C07D319/18; C07D333/20; C07D405/12; C07D409/12
Domestic Patent References:
JP2002508364A2002-03-19
JPH10505853A1998-06-09
JPH08505156A1996-06-04
JPH07501803A1995-02-23
JPH04282371A1992-10-07
JPH06166676A1994-06-14
JPS514168A1976-01-14
Foreign References:
GB2303303A1997-02-19
Other References:
JPN7009005201, ベルギー特許第642084号明細書
JPN6009061601, Chemical Abstracts,vol.59,abs.no.8732a−c
Attorney, Agent or Firm:
Eiji Saegusa
Kakehi Yuro
Kenji Saito