Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
13,13a-ジヒドロベルベリン誘導体及びその医薬組成物と用途
Document Type and Number:
Japanese Patent JP2010504919
Kind Code:
A
Abstract:
The present invention provides 13,13a-dihydroberberine derivatives or their physiologically acceptable salts represented by the following formula, pharmaceutical compositions comprising the same, and uses thereof. The 13,13a-dihydroberberine derivatives have an activity of promoting glucose absorption in muscle cells, and the whole animal tests show that the present compounds have effects on improving glucose-tolerance and insulin-resistance, facilitating weight loss, relieving fatty liver and the like. Thus, the present compounds can be used in treating diabetes mellitus, adiposity, fatty liver and complications thereof induced by insulin resistance.

Inventors:
Holly horn
Lithia
Lee Jean Yar
Jahn Hankung
Chuyeon Joey
Jesus Mean
James David E
Kregen Edward W
Application Number:
JP2009529500A
Publication Date:
February 18, 2010
Filing Date:
September 30, 2007
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
Shanghai Institute of Materia Medica Chinese Academy of Sciences
International Classes:
C07D455/03; A61K31/4375; A61P3/04; A61P3/06; A61P3/10; C07D455/06
Domestic Patent References:
JPH11310530A1999-11-09
Foreign References:
WO2006029577A12006-03-23
Attorney, Agent or Firm:
Shizuo Sano
Kazutoshi Shibuya