NEW MATERIAL: A compd. of formula I [where R1 is H, 1-3C alkyl, 3-6C cycloalkyl-1-3C alkyl or ≤8C aralkyl; each of X and Y is Cl, Br, F, 1-3C alkoxy, 1-3C alkyl, OH or CF3; (m) is O-2 and (n) is 0-3].
EXAMPLE: N-acetyl-2-amino-α-(3,4-dimethoxyphenyl)-N-methylphenethylamine.
USE: An intermediate for preparing phenyl-1,3-benzodiazepine useful as an antidepressant, an analgesic and an antispasmodic.
PROCESS: The compd. of the formula I (where R1 is H) is obtd. by converting 2-(2-nitrophenyl)acetophenone of formula II into oxime of formula III, acylating the oxime with acetic anhydride, carefully reducing the resultant oxime acetate of formula IV with diborane as a reducing agent and further reducing the resultant 2-nitro-α-phenylphenethylamine of formula V.
MANFURETSUDO BUORUMU
CHIYAARUZU ANSONII KURITSUCHIR
