Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
3'-DEOXYARBINOFURANOSYLPYRIMIDINE NUCLEOSIDE DERIVATIVE
Document Type and Number:
Japanese Patent JPS6468395
Kind Code:
A
Abstract:

NEW MATERIAL:A compound shown by formula I (R1 is amino or OH; R2 is H, halogen or alkyl when R1 is amino and R2 is alkyl when R1 is OH) or a salt thereof.

EXAMPLE: 3'-Deoxyarabinofuranosylthymine.

USE: An antiviral agent and anti-retroviral agent.

PREPARATION: A protecting group is introduced to the 5-position of a compound shown by formula II, an eliminable group is introduced to the 2'-position and when R1 of basic part is amino group, a protecting group is introduced to the amino group. The compound shown by formula II is treated with an alkali to give a compound shown by formula III. Then 2-2' bond of the compound is hydrolyzed and the compound is deprotected.


Inventors:
MOROZUMI MASAMI
YAMAGUCHI TOSHIFUMI
Application Number:
JP22494087A
Publication Date:
March 14, 1989
Filing Date:
September 08, 1987
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
YAMASA SHOYU KK
International Classes:
A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7068; A61P31/12; C07H19/06; C07H19/067; C07H19/09; (IPC1-7): A61K31/70; C07H19/067