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Patent Searching and Data


Title:
3-FLUOROMETHYL-PYRIDOBENZOXAZINE DERIVATIVE
Document Type and Number:
Japanese Patent JPS61271292
Kind Code:
A
Abstract:

NEW MATERIAL:The compound of formula I (R1 and R2 are H or lower alkyl) and its salt.

EXAMPLE: 9-Fluoro-3-fluoromethyl-2, 3-dihydro-10-( 4-methyl-1-piperazinyl )-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid.

USE: Antibacterial agent soluble in water and having low toxicity.

PREPARATION: The objective compound can be produced by (1) reacting the compound of formula II (R3 is lower alkyl) with diethylamino-sulfatrifluoride in dehydrated dichloromethane, (2) hydrolyzing the resultant compound of formula III under acidic condition to obtain the corresponding carboxylic acid of formula IV, and (3) reacting the acid with a piperazine derivative in a polar solvent.


Inventors:
HAYAKAWA ISAO
SHINKO SEIGO
Application Number:
JP11372685A
Publication Date:
December 01, 1986
Filing Date:
May 27, 1985
Export Citation:
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Assignee:
DAIICHI SEIYAKU CO
International Classes:
C07D498/06; A61K31/535; A61P31/04; C07D221/00; C07D265/00; (IPC1-7): A61K31/535; C07D221/00; C07D265/00; C07D498/06