Title:
抗不整脈薬としての3環性ベンゾピラン化合物
Document Type and Number:
Japanese Patent JP2007530436
Kind Code:
A
Abstract:
This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.
Inventors:
Kazuhiko Nariyori
Yukihiro Shigeta
Uesugi Osamu
Okada Takumi
Tomoyuki Matsuda
Yukihiro Shigeta
Uesugi Osamu
Okada Takumi
Tomoyuki Matsuda
Application Number:
JP2006530022A
Publication Date:
November 01, 2007
Filing Date:
March 23, 2005
Export Citation:
Assignee:
Nissan Chemical Industry Co., Ltd.
International Classes:
C07D491/052; A61K31/4188; A61K31/4738; A61K31/4985; A61K31/5383; A61P9/06; C07D491/04; C07D498/04; C07D513/04; C07D515/04
Domestic Patent References:
| JPH07300414A | 1995-11-14 | |||
| JPH04290876A | 1992-10-15 | |||
| JPH03141286A | 1991-06-17 | |||
| JPH024791A | 1990-01-09 |
Foreign References:
| EP0327127A1 | 1989-08-09 |
Attorney, Agent or Firm:
Calyx
Miyazaki Yoshio
Mitsuo Tateishi
Toshio Nakamura
Tsutomu Kato
Kaoru Onozuka
High Masahiro
Yusuke Murakoshi
Miyazaki Yoshio
Mitsuo Tateishi
Toshio Nakamura
Tsutomu Kato
Kaoru Onozuka
High Masahiro
Yusuke Murakoshi