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Title:
【発明の名称】三環式カルボキシアミド類
Document Type and Number:
Japanese Patent JP2002522436
Kind Code:
A
Abstract:
Compounds of formula (I) or salt thereof or solvate thereof, in which: m is 1 or 2; n is 1 or 2; X is CH or N; Y is selected from hydrogen, halogen, cyano, CF3, alkyl or alkoxy; R<1>, which may be at any position within the saturated ring system, is hydrogen or up to two substituents which may be the same or different and each of which is selected from fluoro and C1-6 alkyl; R<2> is hydrogen or up to four substituents selected from halogen, NO2, CN, N3, CF3O-, CF3S-, CF3CO-, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO-, C1-6-alkylCO-, C3-6cycloalkylO-, C3-6cycloalkylCO-, C3-6cycloalkyl-C1-4alkylO-, C3-6cycloalkyl-C1-4alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS-, C1-6alkylSO2-, (C1-4alkyl)2NSO2-, (C1-4alkyl)NHSO2-, (C1-4alkyl)2NCO-, oxazolyl, (C1-4alkyl)NHCO-, CONH2; or R<4>CONH- or -NR<4>R<5>, wherein R<4> is hydrogen or C1-4 alkyl; and R<5> is hydrogen, C1-4alkyl, formyl, -CO2C1-4alkyl or -COC1-4alkyl; or two R<2> groups are linked together form a carbocyclic or heterocyclic ring that is saturated or unsaturated and unsubstituted or substituted by -OH or =O are indicated to be useful in the treatment and pophylaxis of epilepsy, migraine, and other disorders.

Inventors:
Stephen Coulton
Ricardo Novelli
Roderick Alan Porter
Marvin Thompson
Robert William Ward
Application Number:
JP2000563653A
Publication Date:
July 23, 2002
Filing Date:
August 03, 1999
Export Citation:
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Assignee:
SmithKline Beecham Public Limited Company
International Classes:
A61K31/4375; A61K31/4745; A61K31/55; A61P9/10; A61P25/00; A61P25/02; A61P25/08; A61P25/10; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; C07D455/03; C07D471/04; C07D471/14; C07D487/04; (IPC1-7): C07D471/04; A61K31/4375; A61K31/4745; A61K31/55; A61P9/10; A61P25/00; A61P25/02; A61P25/08; A61P25/10; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; C07D471/14; C07D487/04
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)