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Patent Searching and Data

Document Type and Number:
Japanese Patent JPH10505610
Kind Code:
An improved process for the preparation of R(+)1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-yl)methyl]pyridine by a novel synthesis is described where 5-oxo-3-phenyl-3-cyclohexene-carboxylic acid is converted in five operations to the desired product, as well as processes for the resolution of 5-oxo-3-phenyl-3-cyclohexenecarboxylic acid using cinchonidine to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboylic acid or alpha -chymotrypsin to selectively hydrolyze n-butyl 5-oxo-3-phenyl-3-cycohexenecarboxylate to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboxylic acid as well as other valuable intermediates used in the processes.

Butler, Donald Eugene
Gary, The Yodot
Leung, Toun Vuang
Smith, william jeong the third
Wustrow, Derfuit Yourgen
Application Number:
Publication Date:
June 02, 1998
Filing Date:
July 28, 1995
Export Citation:
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Warner-Lambert Company
International Classes:
C07C51/48; C07C51/487; C07C61/39; C07C62/38; C07C69/757; C07D211/70; C07D453/04; (IPC1-7): C07D211/70; C07C51/48; C07C62/38; C07C69/757
Attorney, Agent or Firm:
Chika Takagi (2 outside)