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Title:
【発明の名称】R(+)1,2,3,6-テトラヒドロ-4-フェニル-1-〔(3-フェニル-3-シクロヘキセン-1-イル)メチル〕ピリジン、中枢神経系薬剤のための改善された方法
Document Type and Number:
Japanese Patent JPH10505610
Kind Code:
A
Abstract:
An improved process for the preparation of R(+)1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-yl)methyl]pyridine by a novel synthesis is described where 5-oxo-3-phenyl-3-cyclohexene-carboxylic acid is converted in five operations to the desired product, as well as processes for the resolution of 5-oxo-3-phenyl-3-cyclohexenecarboxylic acid using cinchonidine to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboylic acid or alpha -chymotrypsin to selectively hydrolyze n-butyl 5-oxo-3-phenyl-3-cycohexenecarboxylate to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboxylic acid as well as other valuable intermediates used in the processes.

Inventors:
Butler, Donald Eugene
Gary, The Yodot
Leung, Toun Vuang
Smith, william jeong the third
Wustrow, Derfuit Yourgen
Application Number:
JP51017596A
Publication Date:
June 02, 1998
Filing Date:
July 28, 1995
Export Citation:
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Assignee:
Warner-Lambert Company
International Classes:
C07C51/48; C07C51/487; C07C61/39; C07C62/38; C07C69/757; C07D211/70; C07D453/04; (IPC1-7): C07D211/70; C07C51/48; C07C62/38; C07C69/757
Attorney, Agent or Firm:
Chika Takagi (2 outside)