Title:
4-POSITION ETHER DERIVATIVE OF DEOXYDIACETYL-FLUOROURIDINE
Document Type and Number:
Japanese Patent JPS5728083
Kind Code:
A
Abstract:
NEW MATERIAL:The titled compound shown by the formula [R is (substituted) benzyl, 1WtC alkyl].
EXAMPLE: O4-Methyl-2'-deoxy-3',5'-di-O-acetyl-5-fluorouridine.
USE: An antitumor agent.
PROCESS: (A) Preferably one equivalent 2'-deoxy-3'-5'-di-O-acetyl-5-fluorourdine is reacted with (B) 1W3 equivalent silver compound, e.g., silver oxide, etc. and (C) 1W7 equivalent halide (preferably, iodide, bromide) shown by the formula RX (X is halogen) is an organic solvent, preferably acetone, etc. at room temperature W the reflux temperature of the solvent for 30min W 3 days.
Inventors:
FUJII SETSUO
YASUI BONPEI
FUKUMORI SATOSHI
MIYAMOTO TOMOHISA
ANDOU KAZUKO
HASHIMOTO IWAO
SAWAI YONEICHI
UMEDA NAOKI
KAWASAKI MASAHIRO
YASUI BONPEI
FUKUMORI SATOSHI
MIYAMOTO TOMOHISA
ANDOU KAZUKO
HASHIMOTO IWAO
SAWAI YONEICHI
UMEDA NAOKI
KAWASAKI MASAHIRO
Application Number:
JP10295680A
Publication Date:
February 15, 1982
Filing Date:
July 25, 1980
Export Citation:
Assignee:
FUNAI PHARMACEUTICAL IND LTD
International Classes:
C07H19/073; A61K31/505; A61K31/70; A61K31/7042; A61K31/7052; A61K31/7064; A61K31/7072; A61P35/00; C07D405/04; (IPC1-7): A61K31/505; C07D405/04
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