Title:
治療薬としての4-アリールキノール類およびその類似体
Document Type and Number:
Japanese Patent JP2004533486
Kind Code:
A
Abstract:
The present invention pertains to compounds of the following formula, which are, inter alia, antiproliferative agents, anticancer agents, antimycobacterial agents, antituberculosis agents, and/or thioredoxin/thioredoxin reductase inhibitors: wherein: Q is -O or -N-S(-O)2-RQ; RQ is -H or optionally substituted C1-7alkyl, C3-20heterocyclyl, or C5-20aryl; Ar is optionally substituted C5-20aryl; RO is an oxy substituent; the bond marked alpha is a single bond or a double bond; the bond marked beta is a single bond or a double bond; R3 and R5 are each independently ring substituents; R2 and R6 are each independently ring substituents; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for example, in the treatment of proliferative conditions, (e.g., cancer), mycobacterial infections (e.g., tuberculosis), and/or conditions mediated by thioredoxin/thioredoxin reductase.
Inventors:
Stevens, Malcolm, Francis, Graham
Wealth, The Offray
Westwell, Andrew, David
Paul, Tracy, Down
Wealth, The Offray
Westwell, Andrew, David
Paul, Tracy, Down
Application Number:
JP2003510646A
Publication Date:
November 04, 2004
Filing Date:
July 05, 2002
Export Citation:
Assignee:
CANCER RESEARCH TECHNOLOGY LIMITED
International Classes:
C07D333/22; A61K31/122; A61K31/222; A61K31/223; A61K31/343; A61K31/381; A61K31/404; A61K31/4184; A61K31/423; A61K31/426; A61K31/428; A61K31/4402; A61K31/47; A61K38/00; A61P31/06; A61P35/00; A61P43/00; C07C45/30; C07C45/51; C07C49/723; C07C49/747; C07C49/753; C07C69/157; C07C321/22; C07C321/28; C07C323/22; C07C323/59; C07D209/12; C07D213/50; C07D215/14; C07D235/12; C07D263/56; C07D277/10; C07D277/24; C07D277/64; C07D307/80; C07D333/54; C07D333/56; (IPC1-7): C07C49/723; A61K31/122; A61K31/222; A61K31/223; A61K31/343; A61K31/381; A61K31/404; A61K31/4184; A61K31/423; A61K31/426; A61K31/428; A61K31/4402; A61K31/47; A61K38/00; A61P31/06; A61P35/00; A61P43/00; C07C49/753; C07C69/157; C07C321/22; C07C321/28; C07D209/12; C07D213/50; C07D215/14; C07D235/12; C07D263/56; C07D277/10; C07D277/24; C07D277/64; C07D307/80; C07D333/22; C07D333/56
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Ishii Teiji
Satoshi Fujita
Eiichi Arai
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