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Patent Searching and Data


Title:
5-(4-@(3754/24)ETHOXYCARBONYL)OXY-3-METHOXYPHENYL)-2,4-PENTADIENOIC ACID CHLORIDE AND ITS PRODUCTION
Document Type and Number:
Japanese Patent JPH06184054
Kind Code:
A
Abstract:

PURPOSE: To provide the subject compound useful as an intermediate for medicines such as antiallergic agents and nephritis therapeutic agents and to provide a method for producing the same.

CONSTITUTION: 5-[4-(Ethoxycarbonyl)oxy-3-methoxyphenyl]-2,4-pentadienoic acid chloride of formula I. This compound is produced by reacting 5-(4- hydroxy-3-methoxyphenyl)-2,4-pentadienoic acid of formula II with ethyl chlorocarbonate and subsequently treating the produced compound of formula III with a chlorinating agent. The compound of formula I can be reacted with 2-(4-diphenylmethoxy-1-piperidinylethylamine to provide an amide compound, 4-[5-[[2-(4-diphenylmethoxy-1-piperidinyl)ethyl]amino]-5-oxo-1,3-pentadienyl]-2- methoxyphenyl ethyl carbonate ester which is useful as a medicine.


Inventors:
MURAOKA YASUTO
KIMURA IKUO
Application Number:
JP1992000279163
Publication Date:
July 05, 1994
Filing Date:
September 25, 1992
Export Citation:
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Assignee:
HODOGAYA CHEMICAL CO LTD
TERUMO CORP
International Classes:
A61K31/265; A61P13/02; A61P15/00; A61P37/08; C07C68/06; C07C69/96; (IPC1-7): C07C69/96; C07C68/06