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Patent Searching and Data


Title:
5-AMINO-6-CYCLOHEXYL-4-HYDROXY-HEXANEAMIDE DERIVATIVE AS INHIBITOR AGAINST PRODUCTION OF BETA-AMYLOID PROTEIN
Document Type and Number:
Japanese Patent JPH09169713
Kind Code:
A
Abstract:

To obtain the subject new compound having a specific inhibition action on γ-secretase, acting so as to prevent accumulation of amyloid in brain and useful for treating Alzheimer's disease, etc.

This compound is represented by formula I (R1 is a 4-8C alkyl, alkenyl, etc.; R2 is H or methyl; R3 is a lower alkyl, a 3-6C cycloalkyl, etc.; R4 is R3, a lower alkyl-thio-lower alkyl, etc.), its pharmaceutically permissible acid addition salt and hydrate, e.g. [αS-(αR*, γR*, δR*)]-N-butyl-γ-hydroxy-α-(1- methylethyl)-δ-[4-methylpentyl]amino]cyclohexanehexaneamide. The compound of formula I is obtained by amidating a compound of formula II (t-BOC is t-butoxycarbonyl-protecting group; R6 is a lower alkyl) used as a raw material, then, carrying out catalytic hydrogenation of the amidated compound to afford a compound of formula III and further carrying out alkylation of the compound of formula III.


Inventors:
KEBIN FUERUSENSUTAIN
DEBITSUDO DABURIYUU SUMISU
MAIKERU EI POSU
PURASADO CHIYATAABEDEYURA
CHIYAARUSU PII SUROON
Application Number:
JP1996000324904
Publication Date:
June 30, 1997
Filing Date:
December 05, 1996
Export Citation:
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Assignee:
BRISTOL MYERS SQUIBB CO
International Classes:
A61K31/16; A61K31/165; A61P25/28; A61P43/00; C07C237/14; C07C237/18; (IPC1-7): C07C237/18; A61K31/16; A61K31/165
Attorney, Agent or Firm:
斉藤 武彦