Title:
5(S)-(2’-ヒドロキシエトキシ)-20(S)-カンプトセシンの結晶形態
Document Type and Number:
Japanese Patent JP2009538343
Kind Code:
A
Abstract:
A 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin diastereoisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2'-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2'-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.
Inventors:
Akera, Venkateswaluru
Arikunge, Shanbas
Ajaya Kumar, Reka
Murangi, Ramesh
Siricila, Raju
Debris, Subra Mania
Rajagopal, Sri Ram
Arikunge, Shanbas
Ajaya Kumar, Reka
Murangi, Ramesh
Siricila, Raju
Debris, Subra Mania
Rajagopal, Sri Ram
Application Number:
JP2009512299A
Publication Date:
November 05, 2009
Filing Date:
May 24, 2007
Export Citation:
Assignee:
Doctor Ladies Laboratories Limited
Doctor Lady's Laboratories, Inc.
Doctor Lady's Laboratories, Inc.
International Classes:
C07D491/22; A61K31/4745; A61P1/00; A61P1/18; A61P11/00; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P35/00; A61P35/02; C07B57/00
Attorney, Agent or Firm:
Takehiko Suzue
Kurata Masatoshi
Satoshi Kono
Nakamura Makoto
Yoshihiro Fukuhara
Ryuji Mine
Toshio Shirane
Muramatsu Sadao
Nobuhisa Nogawa
Katsu Sunagawa
Kazama Tetsuya
Kurata Masatoshi
Satoshi Kono
Nakamura Makoto
Yoshihiro Fukuhara
Ryuji Mine
Toshio Shirane
Muramatsu Sadao
Nobuhisa Nogawa
Katsu Sunagawa
Kazama Tetsuya