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Patent Searching and Data


Title:
5(S)-(2’-ヒドロキシエトキシ)-20(S)-カンプトセシンの結晶形態
Document Type and Number:
Japanese Patent JP2009538343
Kind Code:
A
Abstract:
A 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin diastereoisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2'-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2'-hydroxyethoxy)-20(S)-camptothecin diastereoisomer. Pharmaceutical compositions of the 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin diastereoisomer are also described as are methods of using the compound for the inhibition of topoisomerase I and for the treatment of cancer.

Inventors:
Akera, Venkateswaluru
Arikunge, Shanbas
Ajaya Kumar, Reka
Murangi, Ramesh
Siricila, Raju
Debris, Subra Mania
Rajagopal, Sri Ram
Application Number:
JP2009512299A
Publication Date:
November 05, 2009
Filing Date:
May 24, 2007
Export Citation:
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Assignee:
Doctor Ladies Laboratories Limited
Doctor Lady's Laboratories, Inc.
International Classes:
C07D491/22; A61K31/4745; A61P1/00; A61P1/18; A61P11/00; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P35/00; A61P35/02; C07B57/00
Attorney, Agent or Firm:
Takehiko Suzue
Kurata Masatoshi
Satoshi Kono
Nakamura Makoto
Yoshihiro Fukuhara
Ryuji Mine
Toshio Shirane
Muramatsu Sadao
Nobuhisa Nogawa
Katsu Sunagawa
Kazama Tetsuya