【発明の名称】N-〔〔5-(トリフルオロメチル)-6-メトキシ-1-ナフタレニル〕チオキソメチルまたはカルボニル〕-N-メチルグリシンアミド

Title:

【発明の名称】N-〔〔5-(トリフルオロメチル)-6-メトキシ-1-ナフタレニル〕チオキソメチルまたはカルボニル〕-N-メチルグリシンアミド

Document Type and Number:

Japanese Patent JPH0623152

Kind Code:

B2

Abstract:

Disclosed herein are tolrestat and oxotolrestat amides and methods of preparation. The amides have the formulawherein R is -NH₂, -NHCH₃, -N(CH₃)_2'orand X is oxygen or sulfur. The amides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

Inventors:

KAJIMIIRU SESUTANJI
EKUARUDO ESU FUERUDEINANDEI
MAIKERU KUREMURU
FURANSESUKO BERIINI

Application Number:

JP13000886A

Publication Date:

March 30, 1994

Filing Date:

June 03, 1986

Export Citation:

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Assignee:

AMERIKAN HOOMU PURODAKUTSU CORP

International Classes:

A61K31/165; A61K31/17; A61K31/27; A61K31/70; A61K31/7024; A61P3/08; A61P3/10; A61P13/02; A61P15/00; A61P25/00; A61P27/02; A61P27/12; C07C67/00; C07C231/00; C07C235/66; C07C237/22; C07C239/00; C07C271/20; C07C275/14; C07C275/50; C07C275/70; C07C325/00; C07C327/48; C07H13/04; (IPC1-7): C07C235/66; A61K31/165; A61K31/17; A61K31/27; A61K31/70; C07C237/22; C07C271/20; C07C275/14; C07C275/70; C07C327/48; C07H13/04

Attorney, Agent or Firm:

Aoyama Ryo (2 outside people)

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