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Patent Searching and Data


Title:
7-HYDROXYGUANINE DERIVATIVE, PRODUCTION THEREOF AND ANTITUMOR AGENT CONTAINING SAID DERIVATIVE AS ACTIVE COMPONENT
Document Type and Number:
Japanese Patent JPS61271289
Kind Code:
A
Abstract:

NEW MATERIAL:The compound of formula I (R1 and R2 are H, tetra hydropyranyl or tetrahydrofuryl) and its salt.

USE: An antitumor agent.

PREPARATION: The objective compound can be produced by reacting 7- hydroxyguanine of formula II or its salt with 2,3-dihydropyran or 2,3- dihydrofuran in a polar aprotic solvent (preferably dimethyl sulfoxide) in the presence of an acid catalyst such as hydrochloric acid.


Inventors:
ISHII KIYOTO
KAWARADA HAJIME
WATANABE KIYOSHI
Application Number:
JP1985000113874
Publication Date:
December 01, 1986
Filing Date:
May 27, 1985
Export Citation:
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Assignee:
KANEGAFUCHI CHEMICAL IND
International Classes:
A61K31/52; A61K31/522; A61P35/00; C07D473/18; C12P17/18; C12R1/465; (IPC1-7): A61K31/52; C07D473/18; C12P17/18; C12R1/465