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Title:
77ACYLAMINOO33PYRAZINYLTHIOMETHYLL 33CEPHEMM44CARBOXYLATE PROCESS FOR PREPARING SAME AND ANTIBIOTIC PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
Japanese Patent JPS52142093
Kind Code:
A
Abstract:
7-Acylamino-3-pyrazinylthiomethyl-3-cephem-4-carboxylic acids are disclosed having the general formula: (I) wherein R is an alkyl having from 1 to 5 carbon atoms or +tr wherein Y = Y1 = H Y = Y1 = Cl Y = Cl, Y1 = F Y = H,Y 1 = Cl and IN WHICH N IS AN INTEGER FROM 1 TO 4, X is O or S, and R2 is thienyl, phenyl, 1,4-cyclohexadienyl, phenoxy, pyrazinyl and substituted phenyl, thienyl, pyrazinyl and phenoxy, the substituent being selected from the group consisting of hydroxy, chlorine, bromine, and alkyl and alkoxy having from 1 to 4 carbon atoms; R3 is alkali metal such as sodium or potassium, hydrogen, alkyl having from 1 to 4 carbon atoms, benzyl, trichloroethyl, methoxybenzyl, benzhydryl, pivaloyloxymethyl, and an alkaline earth metal; R1 may be a pyrazinyl of the general formulae: in which R4, R5, R6 are equal or different and are selected from the group consisting of F, Cl, Br, hydrogen, alkyl, phenyl, cyano, thiocyano, carboxyl, carboxyalkyl, carboxamido, thiocarboxamido, hydroxy, alkoxy, thiol, alkylthio, amino, alkylamino, phenylamino. By the terms alkyl, an alkyl having from 1 to 4 carbon atoms is intended. Processes for making them are also disclosed.

Inventors:
JIYORUJIO PARAMIDETSUSHI
FURANKO ZARIINI
JIYOBUANNI FURANCHIESUKI
JIYOBUANNA SUKIOTSUPAKATSUSHI
FUEDERIKO ARUKAMOONE
Application Number:
JP5862277A
Publication Date:
November 26, 1977
Filing Date:
May 20, 1977
Export Citation:
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Assignee:
FARMACEUTICI ITALIA
International Classes:
C07D501/04; A61K31/545; A61K31/546; A61P31/04; C07D501/24; C07D501/36; (IPC1-7): A61K31/545; C07D501/36