9-SUBSTITUTED MINOCYCLINE COMPOUND

Japanese Patent JP2012107045

A

To provide novel 9-substituted minocycline compounds.

The novel 9-substituted minocycline compound is expressed by the following formula. A region of naphthylthiourea can be various substituents such as phenylurea and phenylsulfone amide. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.

NELSON MARK L
FRECHETTE ROGER
VISKI PETER
ISMAIL MOHAMED
BOWSER TODD
DUMORNAY JIMMY
RENNIE GLEN
LIU GUI
KOZA DARRELL
SHEAHAN PAUL
STAPLETON KAREN
HAWKINS PAUL
BHATIA BEENA
VERMA ATUL
MCINTYRE LAURA
WARCHOL TAD

JP2012034839A

June 07, 2012

February 21, 2012

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TUFTS COLLEGE
PARATEK PHARM INNC

C07C237/26; C07D317/58; A61K31/16; A61K31/17; A61K31/27; A61K31/343; A61K31/36; A61K31/381; A61K31/44; A61K31/4402; A61K31/4406; A61K31/495; A61K31/65; A61K31/662; A61K31/704; A61P31/04; C07C237/00; C07C237/36; C07C255/59; C07C271/22; C07C271/28; C07C271/30; C07C271/54; C07C271/58; C07C275/30; C07C275/34; C07C275/38; C07C275/40; C07C275/42; C07C275/50; C07C275/54; C07C279/18; C07C311/06; C07C311/13; C07C311/21; C07C331/24; C07C331/28; C07C333/08; C07C335/22; C07C381/10; C07D213/38; C07D213/56; C07D213/64; C07D295/14; C07D295/155; C07D307/81; C07D317/60; C07D317/62; C07D333/24; C07D333/28; C07F9/40; C07H15/203; A61K; C07C

Hatsushi Shimizu

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