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Patent Searching and Data


Title:
9,10-デヒドロ-12,13-デソキシエポチロン誘導体の調製方法
Document Type and Number:
Japanese Patent JP2008538368
Kind Code:
A
Abstract:
The invention comprises a novel process for the preparation of an epothilone derivative of formula I: wherein R1 and R2 independently from each other represent hydrogen or protecting groups and R3 is methyl or trifluoromethyl, which are useful precursors in the synthesis of the desoxyepothilone derivatives of the formula IV: wherein R3 is methyl or trifluoromethyl. The desoxepothilones of formula IV inhibit the growth of tumor cells and are therefore promising candidates for novel anticancer agents.

Inventors:
Puntener, Kurt
Michelonero, Scalone
Application Number:
JP2008507052A
Publication Date:
October 23, 2008
Filing Date:
April 11, 2006
Export Citation:
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Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D417/06; A61K31/427; A61P29/00; A61P35/00; A61P37/06; C07B61/00
Foreign References:
WO2004018478A22004-03-04
Attorney, Agent or Firm:
Aoki Atsushi
Ishida Kei
Fukumoto product
Tetsuji Koga
Ayako Okamura