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Acetaminophen conjugate, its constituent, and its directions for use
Document Type and Number:
Japanese Patent JP6029670
Kind Code:
Acetaminophen conjugates are provided, which have an acetaminophen moiety covalently linked to a second moiety. The conjugates provided may have one or more advantageous properties, including increased water solubility as compared to acetaminophen, reduced toxicity profile as compared to acetaminophen and an altered pharmacokinetic profile. Formulations comprising the conjugates are also provided, as are methods of using the conjugates and kits comprising the conjugates.

Brae, Keith Earl.
Jean De Leit, Bernd
Application Number:
Publication Date:
November 24, 2016
Filing Date:
September 21, 2012
Export Citation:
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Accordor Therapeutics, ink.
International Classes:
C07C329/06; A61K31/265; A61K31/27; A61P9/10; A61P25/00; A61P29/00; C07C313/02
Foreign References:
Other References:
The Conjugation of 2-Amino-ethanesulfinic acid (Hypotaurine) with Cholic Acid by Rat Liver Microsomes,Acta Chemica Scandinavica,1956年,10,pp. 1046-1047
Comparison of the protective actions of N-acetylcysteine, hypotaurine and taurine against acetaminophen-induced hepatotoxicity in the rat,Journal of Biomedical Science,2010年,17 (Suppl 1): S35
Protective effects of MENSA (2-mercaptoethane sulphonate) against acetaminophen-induced hepatorenal oxidative damage in mice,JOURNAL OF APPLIED TOXICOLOGY,2005年,25,pp. 20-29
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita