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Title:
ACYLANILIDE, MANUFACTURE AND ANTIANDROGENIC MEDICINAL OR VETERINARY COMPOSITION
Document Type and Number:
Japanese Patent JPS5933250
Kind Code:
A
Abstract:
Acylanilides of the formula wherein R1 and R2, the same or different, each is cyano, carbamoyl, nitro, halogeno, perfluoroalkyl or other defined substituents; R3 is hydrogen or halogen; R4 is hydrogen or alkyl, or is joined to R5; R5 is hydrogen, hydroxy, alkoxy or acyloxy or is joined to R4; R6 is alkyl or halogenoalkyl, or has the formula -A3-R8 or -A4-X2-A5-R9; A1 and A4, the same or different, each is alkylene; A2, A3 and A5, the same or different, each is a direct link or alkylene; X1 and X2, the same or different, each is oxygen, sulphur, sulphinyl, sulphonyl, imino or alkylimino; R7 and R9, the same or different, each is alkyl, alkenyl, hydroxyalkyl, cycloalkyl, phenyl optionally substituted, naphthyl or heterocyclic optionally substituted; and R8 is phenyl, naphthyl or heterocyclic as defined above for R7 or R9; processes for their manufacture and pharmaceutical compositions containing them. The acylanilides possess antiandrogenic activity.

Inventors:
HAWAADO TATSUKAA
Application Number:
JP13108583A
Publication Date:
February 23, 1984
Filing Date:
July 20, 1983
Export Citation:
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Assignee:
ICI LTD
International Classes:
A61K31/165; A61K8/00; A61K8/11; A61K31/19; A61K31/195; A61K31/215; A61K31/22; A61K31/275; A61K31/415; A61K31/425; A61K31/426; A61K31/428; A61K31/433; A61K31/44; A61K31/4402; A61K31/505; A61P5/00; A61P15/00; A61P17/00; A61P43/00; A61Q5/00; C07C59/68; C07C67/00; C07C231/00; C07C231/02; C07C231/08; C07C233/02; C07C235/16; C07C235/24; C07C237/00; C07C237/04; C07C237/30; C07C253/00; C07C255/60; C07C313/00; C07C315/02; C07C317/00; C07C317/18; C07C317/28; C07C317/32; C07C317/40; C07C317/46; C07C317/48; C07C317/50; C07C319/20; C07C323/25; C07C323/26; C07C323/31; C07C323/32; C07C323/41; C07C323/60; C07C323/63; C07C323/65; C07D213/32; C07D213/70; C07D213/71; C07D233/00; C07D233/84; C07D239/10; C07D239/38; C07D277/20; C07D277/36; C07D277/70; C07D277/74; C07D285/12; C07D285/125; C07D303/48; C07D333/34; C07D333/62; (IPC1-7): A61K31/165; A61K31/19; A61K31/215; A61K31/275; A61K31/41; A61K31/425; A61K31/44; A61K31/505; C07C59/125; C07C103/34; C07C121/78; C07C147/06; C07C147/14; C07C149/20; C07C149/23; C07C149/40; C07C149/41; C07C149/42; C07C149/43; C07D213/70; C07D213/71; C07D239/38; C07D277/36; C07D277/74; C07D285/12; C07D333/34
Domestic Patent References:
JPS52128329A1977-10-27