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Title:
ACYLATED GLP-1/GLP-2 DUAL AGONISTS
Document Type and Number:
Japanese Patent JP2019214583
Kind Code:
A
Abstract:
To provide a compound having agonist activity at the GLP-1 (glucagon-like peptide 1) and GLP-2 (glucagon-like peptide 2) receptors.SOLUTION: The compound is a GLP-1/GLP-2 dual agonist or pharmaceutically acceptable salt or solvate thereof represented by the formula R-X-U-R. (In the formula, Ris hydrogen, Calkyl, acetyl, formyl, benzoyl or trifluoroacetyl; Ris NHor OH; Xis a specific peptide; U is absent or a specific sequence of 1-15 residues.SELECTED DRAWING: None

Inventors:
BJARNE DUE LARSEN
JONATHAN GRIFFIN
LISE GIEHM
ALISTAIR VINCENT GORDON EDWARDS
Application Number:
JP2019135379A
Publication Date:
December 19, 2019
Filing Date:
July 23, 2019
Export Citation:
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Assignee:
ZEALAND PHARMA AS
International Classes:
C07K14/605; A61K38/26; A61P1/00; A61P1/04; A61P1/12; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P43/00
Domestic Patent References:
JP2008539713A2008-11-20
JP2015517299A2015-06-22
Foreign References:
WO2016066818A12016-05-06
WO2015067716A12015-05-14
WO2015067715A22015-05-14
WO2015055801A12015-04-23
Attorney, Agent or Firm:
Murayama Yasuhiko
Shinya Mitsuhiro
Tatsuhiko Abe