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Title:
ALPHA-BENZYLIDENE-GAMMA-BUTYROLACTONE OR GAMMA-BUTYROLACTAM DERIVATIVE
Document Type and Number:
Japanese Patent JPS6239564
Kind Code:
A
Abstract:

NEW MATERIAL:A compound expressed by formula I [Ar is formula II (R3 and R4 are 1W4C alkyl) or formula III; X is -(CH2)2- or formula IV; Y is O or NH] and a salt of the compound capable of forming the salt.

EXAMPLE: A compound expressed by formula V.

USE: A medicine, antimicrobial agent and tyrosinase inhibitor or an intermediate for many organic compounds, having los toxicity, effective for Gram-positive bacteria and yeasts, suggesting the possibility of being useful as a carcinostatic agent or carcinogenic inhibitor and administered in 10mgW10g, preferably 20 mgW5g/adult/day dose.

PREPARATION: For example, a benzaldehyde expressed by the formula Ar-CHO and ylide expressed by formula VII (Ary is aryl) are subjected to the Wittig reaction to afford the aimed compound expressed by formula I.


Inventors:
SHIRAISHI TADAYOSHI
SHIMADA YOSHIO
FUSE YOSHIHIDE
IMAI NAOHIRO
YAMASHITA KATSUJI
YAMASHITA TOSHIAKI
Application Number:
JP1985000178357
Publication Date:
February 20, 1987
Filing Date:
August 13, 1985
Export Citation:
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Assignee:
KANEGAFUCHI CHEMICAL IND
International Classes:
C07D307/33; A61K31/34; A61K31/341; A61K31/343; A61K31/40; A61K31/4015; A61K31/403; A61K31/404; A61P31/04; A61P43/00; C07D207/36; C07D207/38; C07D209/34; C07D307/32; C07D307/83; (IPC1-7): A61K31/34; A61K31/40; C07D207/38; C07D209/34; C07D307/32; C07D307/83