抗酸化炎症モジュレーター:C-17においてアミノ改変およびその他の改変を加えたオレアノール酸誘導体

Japanese Patent JP2011518191

A

This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

Anderson Eric
Jang Shin
Bisnick melane

JP2011505259A

June 23, 2011

April 20, 2009

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Riata Pharmaceuticals, Inc.

C07J63/00; A61K9/10; A61K9/113; A61K9/127; A61K9/14; A61K9/20; A61K9/28; A61K9/48; A61K9/72; A61K31/56; A61K45/00; A61P1/00; A61P1/04; A61P3/00; A61P3/04; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P13/12; A61P17/02; A61P17/06; A61P17/10; A61P19/02; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P37/08; A61P39/02; A61P43/00; C07J71/00

JP2006347952A	2006-12-28
JP2001240573A	2001-09-04
JP2006515859A	2006-06-08
JP2002530272A	2002-09-17

CN101117348A

2008-02-06

JPN7013004348; Ｂｏｔａｎｉｃａｌ　Ｓｔｕｄｉｅｓ ４７, 2006, ３３９-３６８
JPN7013004349; Ｔｅｔｒａｈｅｄｒｏｎ １８, 1962, ８２７-８３８
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JPN6009033009; ＨＯＮＤＡ，Ｔ．　ｅｔ　ａｌ: 'Ｓｙｎｔｈｅｔｉｃ　Ｏｌｅａｎａｎｅ　ａｎｄ　Ｕｒｓａｎｅ　Ｔｒｉｔｅｒｐｅｎｏｉｄｓ　ｗｉｔｈ　Ｍｏｄｉｆｉｅｄ　Ｒｉｎｇｓ　Ａ　ａｎｄ　Ｃ：　Ａ　Ｓｅｒｉｅｓ　ｏｆ　Ｈｉｇｈｌｙ　Ａｃｔｉｖｅ　Ｉ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４３，　Ｎｏ．２２, 2000, ｐ．４２３３-４２４６
JPN6009033015; ＨＯＮＤＡ，Ｔ．　ｅｔ　ａｌ: 'Ｄｅｓｉｇｎ　ａｎｄ　ｓｙｎｔｈｅｓｉｓ　ｏｆ　２-ｃｙａｎｏ-３，１２-ｄｉｏｘｏｏｌｅａｎ-１，９-ｄｉｅｎ-２８-ｏｉｃ　ａｃｉｄ，　ａ　ｎｏｖｅｌ　ａｎｄ　ｈｉｇｈｌｙ　ａｃｔｉｖｅ　ｉｎｈｉ' Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ Ｖｏｌ．８，　Ｎｏ．１９, 1998, ｐ．２７１１-２７１４

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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