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Title:
ANTIBACTERIAL AGENT
Document Type and Number:
Japanese Patent JPS6450884
Kind Code:
A
Abstract:

NEW MATERIAL: The compd. of formulas I, II {Z is formulas III to V [(n) is 0 or 1; R5 and R6 are H, methyl, benzyl, etc., when R6 is H, n=1; R7 to R9 are H or methyl, when R6 is H, at least one of R8, R9 is methyl, R10 is methyl, ethyl, etc.; R17, R18 are H, NR19R20 (R19, R20 are H, 1 to 3C alkyl, etc.), etc.], etc.; W is O, NR21 (R21 is H, 1 to 3C alkyl, etc.), S, etc.; X is CH, CF, N, etc.; Y is H, F or amino; R1 is H, 1 to 6C alkyl or cation; R2 is 1 to 4C alkyl, vinyl, etc.; R3, R4 are H or 1 to 3C alkyl}.

EXAMPLE: 7-(2-Azabicyclo[2,2,1]heptane)-6,8-difluoro-1-cyclopropyl-1,4-dihydro-4- oxo-3-quinoline carboxylic acid.

USE: An antibacterial agent.

PROCESS: A 6,8-diazabicyclo[3,2,2]nonanedihydrochloride is formed by starting from 2,6-diaminoheptanedioxic acid and is brought into reaction with formulas VI, VII.


Inventors:
MAARANDO POORU HATSUTO JIYUNIA
JIYON SUTEIIBUN KIIRII
Application Number:
JP18858688A
Publication Date:
February 27, 1989
Filing Date:
July 29, 1988
Export Citation:
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Assignee:
WARNER LAMBERT CO
International Classes:
A61K31/44; A61K31/47; A61K31/495; A61K31/535; A61P31/04; C07D401/04; C07D451/04; C07D455/04; C07D471/04; C07D471/08; C07D487/08; C07D519/00; (IPC1-7): A61K31/44; A61K31/47; A61K31/495; A61K31/535; C07D455/04; C07D471/04; C07D471/08; C07D487/08; C07D519/00
Attorney, Agent or Firm:
Chika Takagi (2 outside)