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Title:
ANTIBIOTIC A-39893
Document Type and Number:
Japanese Patent JPH0725896
Kind Code:
A
Abstract:

PURPOSE: To provide a new antibiotic useful as an antibacterial agent for Gram- positive bacteria such as Staphylococcus aureus and Staphylococcus epidermidis.

CONSTITUTION: The objective compound of the formula (R1 is mannosylglucose; R2 is mannose; R3 is ristosamine), which can be obtained by culturing A-39893- productive bacteria which belong to Actinoplanes such as Actinoplanes missouriensis SANK 60993 strain (FERM-BP-4331). This compound has the following physicochemical characteristics: (1) properties: amphoteric, soluble to water, white powdery; (2) specific optical rotation: [α]25D=-7.2° (C=0.1, 0.01N-HCl); (3) elemental analysis (%): C: 49.93, H: 5.07, N: 5.14, Cl: 2.26; (4) molecular formula: C89H99N8O40C1; (5) molecular weight: 1954 (FAB-MS): [M+H]+, 1995: with Cl as 35); (6) solubility: soluble to water, methanol, sparingly soluble to acetone, insoluble to ethyl acetate, chloroform, benzene.


Inventors:
INUKAI MASATOSHI
TAKEUCHI MICHIKO
OTANI HIROKO
OKAZAKI HISAO
ENOKIDA RYUZO
NAKAMURA KATSUMICHI
SATO AKIRA
Application Number:
JP1993000168781
Publication Date:
January 27, 1995
Filing Date:
July 08, 1993
Export Citation:
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Assignee:
SANKYO CO
International Classes:
A61K38/00; A61P31/04; C07K7/64; C07K14/195; C07K14/41; C12P21/04; C12R1/045; (IPC1-7): C07K7/64; C12P21/04
Attorney, Agent or Firm:
大野 彰夫 (外2名)