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Title:
ANTIBODY AGAINST BRAIN-DERIVED MEMBRANE PROTEIN
Document Type and Number:
Japanese Patent JPH03178999
Kind Code:
A
Abstract:

PURPOSE: To provide the subject antibody binding specifically to a composition containing a specific fragment, modulating response to the composition, retarding the neoplastic growth and binding specifically to a membrane protein.

CONSTITUTION: The objective antibody binding to a polypeptide having an amino acid composition almost identical to that of a membrane protein or a fragment composition beginning the methionine at the position of 37, 68 or 69 and modulating the response to the composition or its immunological fragment. For example, the antibody is separated preferably from the brain tissue by gel permeation column with acidic aqueous acetonitrile and then by reversed phase HPLC with acidic acetonitrile having a linear gradient concentration.


Inventors:
SHIYOYABU MOHAMETSUDO
MARUKAATO HANSU
TODARO JIYOOJI JIEI
Application Number:
JP1990000269728
Publication Date:
August 02, 1991
Filing Date:
October 09, 1990
Export Citation:
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Assignee:
ONCOGEN
International Classes:
C12P21/08; A61K38/00; A61K39/395; A61P9/00; A61P25/20; A61P25/26; A61P35/00; A61P37/00; A61P43/00; C07C43/23; C07C323/16; C07C323/20; C07D323/00; C07D405/12; C07H21/04; C07K1/14; C07K1/20; C07K7/06; C07K7/08; C07K14/00; C07K14/005; C07K14/195; C07K14/435; C07K14/47; C07K14/705; C07K16/00; C07K16/18; C12N15/00; C12N15/09; C12P21/00; C12P21/02; G01N33/50; G01N33/53; G01N33/531; C12R1/19; C12R1/91; (IPC1-7): A61K39/395; C07K7/06; C07K7/08; C07K7/10; C07K15/14; C07K99/00; G01N33/53
Domestic Patent References:
JP62501841Y