Title:
ANTIHYPERTENSIVE COMBINATION MEDICINE
Document Type and Number:
Japanese Patent JPH05194217
Kind Code:
A
Abstract:
PURPOSE: To provide a drug containing a certain kind of tetrahydronaphthalene derivative in combination with pyridazodiazepine, having synergistically improved hypotensive effect of individual components to enable the reduction of the administration dose and eliminate or remarkably reduce the side actions. CONSTITUTION: This agent for the control or prophylaxis of especially hypertension and causal damages contains a tetrahydronaphthalene derivative of the formula I (R<1> is a halogen; R<2> is a lower alkoxy-lower alkylcarbonyloxy; X is a 2-8C alkylene; A is benzimidazolyl which may be substituted with a 1-12C alkyl at the N atom) in combination with a pyridazodiazepine of the formula II (R<4> is an aralkyl having monosubstituted phenyl; R<5> and R<6> are each a 1-6C alkyl; R<7> and R<8> are each H or together form oxo). The weight ratio of the compound of the formula I to the compound of the formula II is preferably (20-2):1. Both compounds are preferably used especially as a free base, a hydrate or a pharmacologically usable salt.
Inventors:
JIYANNPOORU KUROOZE
RITA MIYURURERU
BUORUFUGANGU OSUTERURIIDERU
RITA MIYURURERU
BUORUFUGANGU OSUTERURIIDERU
Application Number:
JP21662992A
Publication Date:
August 03, 1993
Filing Date:
July 23, 1992
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K31/235; A61K31/415; A61K31/4184; A61K31/55; A61K31/551; A61K45/06; A61P9/12; (IPC1-7): A61K31/415
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)