Title:
ANTIITUMOR GLYCOSIDE AND PREPARATION THEREOF
Document Type and Number:
Japanese Patent JPS51133262
Kind Code:
A
Abstract:
Disclosed is a process for preparing glycoside antitumor antibiotics, including the known compounds daunomycin, adriamycin, 4'-epi-daunomycin and 4'-epi-adriamycin and the novel antibiotics, 3',4'-epi-6'-hydroxydaunomycin, 3',4'-epi-6'-hydroxyadriamycin. 3',4'-epi-daunomycin, 3',4'-epi-adriamycin, 4-demethoxy-4'-epi-daunomycin and 4-demethoxy-4'-epi-adriamycin. Process involves reacting daunomycinone or 4-demethoxy-daunomycinone with a protected 1-halo derivative of 3,4-epi-6-hydroxydaunosamine, 3,4-epi-daunosamine or 4-epi-daunosamine in an inert solvent in the presence of a soluble silver salt catalyst to form a protected derivative of the glycoside antibiotic and removing the protecting groups.
Inventors:
FUEDERIKO ARUKAMONE
ARUBERUTO BARUJIOTSUCHI
AURERIO JI MARUKO
SERUJIO PENKO
ARUBERUTO BARUJIOTSUCHI
AURERIO JI MARUKO
SERUJIO PENKO
Application Number:
JP4930876A
Publication Date:
November 18, 1976
Filing Date:
April 28, 1976
Export Citation:
Assignee:
FARMACEUTICI ITALIA
International Classes:
A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61P35/00; C07H15/252; G04B37/00; (IPC1-7): A61K31/70; C07H15/26