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Title:
ANTITUMOR AGENT
Document Type and Number:
Japanese Patent JPS58210020
Kind Code:
A
Abstract:

PURPOSE: An orally administrable antitumor agent, containing 24S,25-dihydroxycholecalciferol as an active constituent, and capable of exhibiting cellulicidal effects on cancerous cells in vitro.

CONSTITUTION: An antitumor agent containing 24S,25-dihydroxycholecalciferol expressed by the formula as an active constituent. The above-mentioned compound exhibits the inhibitory action on the multiplication of tumorous cells or cellulicidal effects on K-562 cells derived from human leukemias and LICR-LON- HMy2 cells derived from human myelomas in vitro and further antitumor effects found even in tests using mice and rats as hosts. The daily dose thereof is 0.1W10,000μg, preferably 0.5W1,000μg, for adults administered parenterally or orally.


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Inventors:
MAEDA YUUJI
FUJII TAKAMI
KOBAYASHI YASUHIKO
SAITOU KENICHI
KATOU TADAAKI
YOSHIKUMI CHIKAO
Application Number:
JP9232482A
Publication Date:
December 07, 1983
Filing Date:
May 31, 1982
Export Citation:
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Assignee:
KUREHA CHEMICAL IND CO LTD
International Classes:
A61K31/59; A61P35/00; (IPC1-7): A61K31/59
Domestic Patent References:
JPS5832823A1983-02-25
Attorney, Agent or Firm:
Yoshio Kawaguchi



 
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