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Title:
ASCORBIC ACID DERIVATIVE, PRODUCTION THEREOF AND ANTIOXIDANT COMPRISING SAID DERIVATIVE
Document Type and Number:
Japanese Patent JPH01228978
Kind Code:
A
Abstract:

NEW MATERIAL:An ascorbic acid derivative shown by formula I [R1 is alkylcarbonylalkyl; X is 2H or =C(CH3)2].

EXAMPLE: L-5,6-O-Isopropylidene-2-O-methylcarbomethylascorbic acid.

USE: An antioxidant. The ascorbic acid derivative has excellent antioxidation, eliminating action on super oxide having possibility of damaging particularly organism molecule and tissue, is preferably useful as a food antioxidant and beautifying cosmetic and also considered to be applicable to a drug for treating diseases caused by superoxide.

PREPARATION: A compound shown by formula II (R3 is arylalkyl) or a compound shown by formula III obtained by treating the compound with an acid is catalytically reduced in the presence of a reducing catalyst such as Pd/C in H2 flow to give a compound shown by formula I wherein X is =(C(CH3)2 when the starting substance is the compound shown by formula II or X is 2H when the starting substance is the compound shown by formula III.


Inventors:
SATO TOSHIO
NIINO YASUNORI
KAKEGAWA TOSHIO
MATSUMOTO HITOSHI
Application Number:
JP1988000055290
Publication Date:
September 12, 1989
Filing Date:
March 09, 1988
Export Citation:
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Assignee:
NIPPON HYPOX LAB INC
International Classes:
A61K31/375; C07D307/62; C07D407/04; C09K15/06; (IPC1-7): C07D307/62; C07D407/04; C09K15/06
Domestic Patent References:
JPS61236772A1986-10-22
JPS60130582A1985-07-12