To provide a benzene ring-fused 5-membered heterocyclic compound having medicinal action such as neurotrophic factor action, neurotrophic factor activity-enhancing action and β-amyloid cytotoxicity-suppressing action.
This compound is represented by general formula (I) [wherein R1 and R2 are each independently hydrogen; a hydrocarbon group; or a heterocyclic group; or R1 and R2 may form a 3- to 8-membered homo- or hetero-cycle together with the adjacent carbon atom; R3 is a cyclic group; hydroxyl or optionally oxo-modified mercapto or amino group; R4 is hydrogen atom, a hydrocarbon group, hydroxyl or optionally oxo-modified mercapto or amino; or R2 and R4 may be united to form a double bond; X is a direct bond or a linear hydrocarbon group; W is oxygen or sulfur; the ring B is a 5 to 8-membered nitrogenous heterocycle; the ring C is a benzene ring; the double line composed of the dotted line and the solid line represents a single or double bond] or a salt or a prodrug thereof. The compound or the salt or the prodrug thereof has excellent neurodegeneration inhibiting activity and migration property toward the brain and has low toxicity and is useful as a preventive and therapeutic agent for neurodegenerative diseases.
MIYAMOTO MASAOMI
OKURA MASAHIRO
TSUKAMOTO TETSUYA
Next Patent: TRIFLUOROPROPYLAMINOPENTANE DERIVATIVE AND METHOD FOR PRODUCING THE SAME