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Patent Searching and Data


Title:
BICYCLIC QUINONE DERIVATIVE, PRODUCTION AND AGENT
Document Type and Number:
Japanese Patent JPH10273469
Kind Code:
A
Abstract:

To obtain a new compound having excellent mitochondria function- activating action and metabolism resistance and useful as a medicine for treatment of Alzheimer's disease, etc.

This compound is represented by formula I (R1 and R2 are each a lower alkyl, etc.; X is a spacer having 1-15 number of atoms of main chain; Y is an acyl, hydroxy, etc.; A ring is a 5-8-membered ring), e.g. 8-(2- ethoxycarbonyl-5,6-dimethoxy-4,7-dioxoindan-2-yl)octanoic acid ethyl ester. The compound of formula I is obtained by reacting a compound of formula II with preferably 2-10 equivalent cerium compound [e.g. cerium(IV)ammonium nitrate] when P and P' of the compound of formula II (P and P' are each a protective group) is methyl group, e.g. in water and an inert solvent such as a nitrile-based solvent, as necessary by using a catalytic amount to 10 equivalent mineral acid (e.g. sulfuric acid), etc., at ambient temperature to 80°C for 1 to 24 hr under stirring.


Inventors:
KATOU KANEYOSHI
OURA TAIICHI
MIYAMOTO MASAOMI
Application Number:
JP2010098A
Publication Date:
October 13, 1998
Filing Date:
February 02, 1998
Export Citation:
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Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD
International Classes:
C07D295/10; A61K31/12; A61K31/122; A61K31/165; A61K31/19; A61K31/20; A61K31/215; A61K31/23; A61K31/40; A61K31/403; A61K31/4035; A61K31/47; A61K31/495; A61K31/535; A61K31/5375; A61P9/00; A61P25/00; A61P25/28; A61P27/02; A61P27/16; A61P43/00; C07C46/06; C07C50/32; C07C50/38; C07C225/24; C07D209/48; C07D211/10; C07D211/58; C07D213/64; C07D213/65; C07D215/22; C07D295/18; (IPC1-7): C07C50/32; A61K31/12; A61K31/165; A61K31/19; A61K31/20; A61K31/215; A61K31/23; A61K31/40; A61K31/47; A61K31/495; A61K31/535; C07C46/06; C07C50/38; C07C225/24; C07D209/48; C07D211/10; C07D211/58; C07D213/64; C07D213/65; C07D215/22; C07D295/10; C07D295/18
Attorney, Agent or Firm:
Tadao Asahina (2 outside)