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Title:
BILE ACID DERIVATIVE
Document Type and Number:
Japanese Patent JPH0892277
Kind Code:
A
Abstract:

To obtain a new bile acid derivative capable of being administered orally in a high dose, useful for the prevention and treatment of hyperlipidemia, etc., by converting a poorly absorbable therapeutic agent for cirrhosis to an absorbable agent.

This bile acid derivative is a compound of the formula: W-X-G [G is formula I (R3 to R8 are each O of carbonyl by joining together, H, OL, SL, NHL or the like; L is a 1-10C alkyl, a 3-8C cycloalkyl, phenyl or the like; Y is OL, NHL, an aminosulfonic acid or the like) ; X is a direct bond, O, S, SO2, COO or the like; W is formula II (Z is OH, NH2 or the like) or the like], e.g. a compound of formula III. Further, the compound of the formula: W-X-G is obtained e.g. by reacting each of the suitable reactive forms of the G and W by a known method in the case that the X is a direct bond.


Inventors:
BUERUNAA KURAAMAA
GIYUNTAA BUESU
Application Number:
JP1995000254512
Publication Date:
April 09, 1996
Filing Date:
September 07, 1995
Export Citation:
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Assignee:
HOECHST AG
International Classes:
A61K38/00; A61K31/575; A61K31/58; A61P1/16; A61P3/06; A61P43/00; C07D213/26; C07D213/56; C07D213/81; C07J9/00; C07J17/00; C07J31/00; C07J41/00; C07J43/00; C07J51/00; C07K5/06; C07K5/062; (IPC1-7): C07J9/00; A61K31/575; A61K31/58; A61K38/00; C07J17/00; C07J31/00; C07J41/00; C07J43/00; C07J51/00; C07K5/062
Attorney, Agent or Firm:
Chika Takagi (2 outside)