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Title:
BREAKAGE OF GLUTATHIONE S-TRANSFERASE-Ω-1 GENE
Document Type and Number:
Japanese Patent JP2003210067
Kind Code:
A
Abstract:

To provide a gene-modified non-human mammal containing broken GST-Ω-1 gene, and to provide an animal cell.

The non-human mammal containing the targeted breakage of glutathione S-transferase-Ω-1 gene, and an animal cell. This method for treating IL-1 mediating and/or inflammation-mediating disorders in mammals contains a step for administering a substance for inhibiting the GST-Ω-1 activity.


Inventors:
ALLEN-MCCONKEY MELANIE R
AUDOLY LAURENT P
GABEL CHRISTOPHER ALLEN
Application Number:
JP2002362676A
Publication Date:
July 29, 2003
Filing Date:
December 13, 2002
Export Citation:
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Assignee:
PFIZER PROD INC
International Classes:
A61K45/00; A61P1/00; A61P7/04; A61P7/06; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C12N5/08; C12N5/10; C12N9/10; C12N15/09; A01K67/027; C12N15/85; C12Q1/68; (IPC1-7): A01K67/027; A61K45/00; A61P1/00; A61P7/04; A61P7/06; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P19/10; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P37/08; A61P43/00; C12N5/10; C12N15/09; C12Q1/68
Attorney, Agent or Firm:
室伏 良信