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Patent Searching and Data


Title:
CARBAPENEM, ANTIBIOTIC PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, ITS PREPARATION AND INTERMEDIATE IN ITS PREPARATION
Document Type and Number:
Japanese Patent JPH06179674
Kind Code:
A
Abstract:

PURPOSE: To prepare a novel compound which is an antibiotic and is useful in the treatment of bacterial infectious diseases in mammals.

CONSTITUTION: This compound expressed by formula I [wherein R1 is 1- hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is H or 1-4C alkyl; R3 is H or 1-4C alkyl; P1 is formula II (wherein 1 or 2 of A, B, C, D, E, F, G and H are each C and the remainder are each CH); and P1 is OH, cyano, 1-4C alkyl, nitro, hydroxy or the like], e.g. (1R,5S,6S,8R,2'S,4'S)-2-(2-(8-carboxyquinol-6- ylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3- carboxylic acid is obtained by deprotecting a compound of formula III [wherein R10 is a protected amino; R13 is a protected hydroxymethyl or the like; R12 is H or a protected amino; and R18 is a (protected) carboxy].


Inventors:
FUREDERIKU ANRI YUNGU
JIYANNKUROODO ARUNOO
Application Number:
JP1993000177903
Publication Date:
June 28, 1994
Filing Date:
July 19, 1993
Export Citation:
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Assignee:
ZENECA LTD
ZENECA PHARMA SA
International Classes:
A61K31/40; A61K31/397; A61K31/435; A61K31/495; A61P31/04; C07D401/00; C07D401/12; C07D401/14; C07D403/00; C07D403/12; C07D403/14; C07D471/04; C07D477/00; C07D477/20; C07D519/00; C07F9/568; (IPC1-7): C07D477/00
Attorney, Agent or Firm:
Toshio Yano (1 outside)