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Title:
CD40 ANTIBODY FORMULATION AND METHOD
Document Type and Number:
Japanese Patent JP2011184446
Kind Code:
A
Abstract:

To provide a method of treating a tumor in a patient and a stable liquid pharmaceutical formulation suitable for parenteral administration comprising administering a CD40 agonist antibody to the patient.

The invention relates to treatment comprising administering to a patient a CD40 agonist antibody or a fragment thereof, wherein the antibody is administered according to an intermittent dosing regimen of at least two cycles, each cycle comprising (a) a dosing period during which a therapeutically effective amount of the CD40 agonist antibody is administered to the patient and thereafter (b) a resting period. In one embodiment, the administration produces a plasma concentration of the antibody of 0.01-10 μg/mL for at least three hours and the resting period is for at least one week. The formulation comprises an anti-CD40 antibody, sodium acetate, sodium chloride, and polysorbate 80.


Inventors:
BEDIAN VAHE
CUSMANO JOHN DANIEL
GLADUE RONALD PAUL
Application Number:
JP2011000100868
Publication Date:
September 22, 2011
Filing Date:
April 28, 2011
Export Citation:
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Assignee:
PFIZER PROD INC
International Classes:
A61K39/395; A61K9/08; A61K47/02; A61K47/12; A61K47/14; A61P35/00; C07K16/28; C07K16/18
Domestic Patent References:
JPH03204821A1991-09-06
JPS63192724A1988-08-10
JP2002504907A2002-02-12
Foreign References:
WO2003040170A22003-05-15
WO2003039485A22003-05-15
WO2003009817A22003-02-06
WO2001048554A12001-07-05
WO2002030463A22002-04-18
WO2001047554A12001-07-05
Attorney, Agent or Firm:
室伏 良信
▲高▼橋 宏次
宮澤 純子
四本 能尚
佐藤 眞紀