Title:
CHIMERIC SPIDER SILK AND USES THEREOF
Document Type and Number:
Japanese Patent JP2019205463
Kind Code:
A
Abstract:
To provide transgenic silkworm production systems for chimera spider silk production.SOLUTION: Provided is a nucleic acid encoding a chimeric spider silk polypeptide, the chimeric spider silk polypeptide comprising in the direction from N-terminal to C-terminal, (a) Bombyx mori fibroin heavy chain (fhc) silk polypeptide N-terminal domain (NTD); (b) one or more repetitive segments comprising one or more spider silk motifs, each repetitive segment comprising one or more copies of an elastic motif, an optional linker, and one or more strength motifs, in the direction from N-terminal to C-terminal; and (c) C-terminal domain (CTD) of fhc silk polypeptide of Bombyx mori.SELECTED DRAWING: Figure 5
Inventors:
MALCOLM JAMES FRASER
RANDY LEWIS
DON JARVIS
KIMBERLY THOMPSON
JOSEPH HULL
MAO YUN-GEN
FLORENCE TEULE
SOHN BONGHEE
KIM YOUNGSOO
RANDY LEWIS
DON JARVIS
KIMBERLY THOMPSON
JOSEPH HULL
MAO YUN-GEN
FLORENCE TEULE
SOHN BONGHEE
KIM YOUNGSOO
Application Number:
JP2019142869A
Publication Date:
December 05, 2019
Filing Date:
August 02, 2019
Export Citation:
Assignee:
UNIV NOTRE DAME DU LAC
International Classes:
C12N15/12; C07K14/435; C07K14/475; C12N5/10; C12N15/63; D01F4/02
Domestic Patent References:
| JP2008506409A | 2008-03-06 | |||
| JP2005502347A | 2005-01-27 |
Foreign References:
| WO2005068495A1 | 2005-07-28 | |||
| WO2009097540A1 | 2009-08-06 | |||
| US5994099A | 1999-11-30 |
Other References:
J MATER SCI, vol. 42, JPN6015044741, 2007, pages 8974 - 8985, ISSN: 0004466988
BMC BIOTECHNOLOGY, vol. 7, no. 5, JPN6018017847, 2007, pages 1 - 17, ISSN: 0004330447
MACROMOLECULAR BIOSCIENCE, vol. 10, JPN6015044743, 9 September 2010 (2010-09-09), pages 998 - 1007, ISSN: 0004330448
MOLECULAR BIOLOGY REPORTS, vol. 37, JPN6015044737, April 2010 (2010-04-01), pages 1815 - 1821, ISSN: 0004330449
BIOSCI BIOTECHNOL BIOCHEM, vol. 71, JPN6015044739, 2007, pages 2943 - 2951, ISSN: 0004330450
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 37, JPN6015044746, 2007, pages 713 - 725, ISSN: 0004330451
BMC BIOTECHNOLOGY, vol. 7, no. 5, JPN6018017847, 2007, pages 1 - 17, ISSN: 0004330447
MACROMOLECULAR BIOSCIENCE, vol. 10, JPN6015044743, 9 September 2010 (2010-09-09), pages 998 - 1007, ISSN: 0004330448
MOLECULAR BIOLOGY REPORTS, vol. 37, JPN6015044737, April 2010 (2010-04-01), pages 1815 - 1821, ISSN: 0004330449
BIOSCI BIOTECHNOL BIOCHEM, vol. 71, JPN6015044739, 2007, pages 2943 - 2951, ISSN: 0004330450
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, vol. 37, JPN6015044746, 2007, pages 713 - 725, ISSN: 0004330451
Attorney, Agent or Firm:
Patent business corporation Kita Aoyama International