Title:
コレステリルエステル転送蛋白阻害剤
Document Type and Number:
Japanese Patent JP2009513573
Kind Code:
A
Abstract:
Compounds of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), A1 and A2 are each an aromatic ring, a 5-6-membered heterocyclic ring, an aromatic ring fused to a heterocyclic ring, a phenyl ring fused to a heterocyclic ring, or a cycloalkyl ring, and Z is an aromatic or heterocyclic ring.
Inventors:
Ali, Amjiyad
Sinclair, Peter Theei
Sinclair, Peter Theei
Application Number:
JP2008533751A
Publication Date:
April 02, 2009
Filing Date:
September 28, 2006
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07C217/56; A61K31/137; A61K31/41; A61K31/4192; A61K31/42; A61K31/4439; A61K45/00; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P7/00; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P9/14; A61P39/02; C07D249/04; C07D257/06; C07D261/14; C07D401/12
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura